CN102365084A - 药剂递送系统 - Google Patents

药剂递送系统 Download PDF

Info

Publication number
CN102365084A
CN102365084A CN2010800040314A CN201080004031A CN102365084A CN 102365084 A CN102365084 A CN 102365084A CN 2010800040314 A CN2010800040314 A CN 2010800040314A CN 201080004031 A CN201080004031 A CN 201080004031A CN 102365084 A CN102365084 A CN 102365084A
Authority
CN
China
Prior art keywords
carrier
housing
capping
fixed
open end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2010800040314A
Other languages
English (en)
Other versions
CN102365084B (zh
Inventor
霍曼·哈菲奇
格雷戈里·穆恩
欧阳洁仪
罗伯特·达克
玛丽亚·霍伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Proteus Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteus Biomedical Inc filed Critical Proteus Biomedical Inc
Publication of CN102365084A publication Critical patent/CN102365084A/zh
Application granted granted Critical
Publication of CN102365084B publication Critical patent/CN102365084B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules

Abstract

根据本发明的用于递送药剂的药剂递送系统包括载体部件和封盖，封盖构造为密封载体部件的内部容积，其中封盖包括生成唯一电流签名的装置。根据本发明实施方式制备以供递送的药剂可用于各种不同的应用中，包括临床试验。

Description

药剂递送系统
交叉引用
依据35U.S.C§119(e)，本申请要求于2009年1月6日提交的美国临时专利申请序列No.61/142,861的申请日的优先权，该申请的内容经引用并入本文。
技术领域
本发明总体涉及电子装置，并且更具体地涉及作为利用电传导传送信息的通信系统的部分的电子装置。
背景技术
对于许多病人来说，当正确地运用时，处方药疗法是有效的疗法。然而，研究表明平均约50％的病人不遵守处方药疗法的给药方案。低比率的坚持药疗法给药方案导致每年大量住院治疗和进入疗养院。仅在美国，近来已经估计由于病人不坚持而导致的成本每年总计高于1000亿美元。
病人坚持尤其重要的一种情形是在临床研究的背景下。临床试验设定中的非坚持具有长期的后果，远超出在试验中可能涉及到的几百个病人。到无校正因子就发生非坚持的程度，可具有范围从不能获得FDA批准到需要增大超过完全遵守人群所需剂量的推荐剂量的效果。这样提升剂量可导致较高的副作用发生率，这反过来可导致进一步的非坚持。
临床研究通常使病人经受特定的药物治疗给药方案，目标是测试与药物治疗对医疗相关的临床终点的效果相关的假设。这些研究可测量例如可选药物治疗与范围从生理测量、生物化学测量或心理测量到疾病的表现、病人存活或生命质量的宽泛种类的临床终点中的任一个之间的关系。另外，药物治疗还必须与任何观察到的不利事件相关联，试图确定少见的不利反作用或与其它药物的相互作用。
将包括药剂和给药方法在内的高度特定的药物治疗给药方案与功效和安全性二者可靠关联的能力，在很大程度上取决于知晓每个病人已遵从处方治疗给药方案的确定性。因此，对病人坚持的监测，包括给药的确切时间，通常对于临床试验资助者以及制药工业具有大的价值。
因此，需要用于跟踪所给药剂和给药的时间点的系统和方法。
发明内容
本发明的装置包括载体部件和构造为密封所述载体部件的内部容积的封盖，其中所述封盖包括对电流流动的信息进行编码的通信装置。所述装置包括可吸收事件标记符识别器或离子发射模块识别器，其利用的是通过与所述装置相接触的导电流体的电传导。本发明的装置可应用于制备药剂。本发明的附加方面包括依据本发明的方法制备的药剂。根据本发明的实施方方式制备的药剂可应用于各种不同的应用，包括临床试验。
附图说明
图1A提供了根据本发明的药剂递送系统的局部剖开的立体主视图，电流签名生成装置位于递送系统的外部上。
图1B提供了根据本发明的药剂递送系统的局部剖开的立体主视图，电流签名生成装置位于递送系统的内部。
图2A提供了图1A的药剂递送系统的分解立体图。
图2B提供了图1B的药剂递送系统的分解立体图。
图3A提供了根据本发明在图1的药剂中使用的封盖的仰视图。
图3B提供了图3A的封盖的侧视图。
图3C提供了图3A的封盖的立体图。
图4提供了根据本发明的带有顶盖的药剂的剖视图。
具体实施方式
本发明的装置包括载体部件和构造为密封所述载体部件的内部容积的封盖，其中所述封盖包括可吸收事件标记符识别器。本发明的装置可应用于制备药剂。本发明的附加方面包括依据本发明的方法制备的药剂。根据本发明的各方面所制备的药剂可应用于各种不同的应用，包括临床试验。
在更加详细地描述本发明时，首先说明本发明的装置和使用所述装置制备药剂的方法，随后讨论这些方法以及组件和包括所述组件的系统的使用。并且，下文中更加详细地说明用于实施本发明的方法的套件。
如上文概述的，提供了装置和使用所述装置制备药剂的方法。术语“药剂”指的是包含已知量活性剂的物理离散的结构，其中所述已知量活性剂是已选择用于给送给活性剂给送事件中受治疗者的已知量活性剂。因此，药剂包含了预定量的药物活性剂(本文也简称为“活性剂”)。计算出存在于药剂中的药物活性剂的量，以当给送到活性剂给送事件中的受治疗者时足以产生期望的效果。由本发明的方法制成的药剂可以具有各种不同构造中的任一种。因此，药剂可以为圆筒形、球形或椭圆形形状、或者任何其它方便的形状。关心的是具有大致胶囊构造的药剂，如下文中更加详细说明的。
本发明的装置包括载体部件和构造为密封所述载体部件的内部容积的封盖，其中所述封盖包括可吸收事件标记符识别器。上述装置的这些部件可以改变，下文中更加详细地描述这些部件的不同方面。
本发明的方法包括用药物活性剂合成物填充载体部件、然后用封盖密封所述载体部件以制成药剂。载体部件为保持一定量药物活性剂合成物的容器。根据药物活性剂合成物的特定性质(下文将进行更加详细地说明)，载体部件可以构造为保持各种类型的合成物，包括液体和固体，固体诸如药粉、药片、包覆粒剂合成物、丸剂、珠和小球体。尽管载体构造为保持的活性剂的容量可以改变，在一些示例中，载体可以构造为保持范围从0至1g的活性剂量，诸如0至100mg且包括0至5mg。载体部件可以具有各种不同的构造。载体部件构造的示例包括但不限于局部盒状、局部球形、局部卵形和局部圆锥形等。
所关心的一种载体部件构造是局部胶囊构造。局部胶囊构造是那些具有第一敞开端和第二封闭端的构造，其中敞开端和封闭端由足以为载体部件提供期望内部容积的距离分隔开。所使用的局部胶囊构造可以具有各种不同的剖面构造，其中剖面构造是由处于敞开端的载体部件的壁限定的形状。所关心的剖面构造包括但不限于圆形、矩形、三角形、方形和椭圆形以及不规则的剖面构造。
本发明的局部胶囊构造的载体部件可以按期望具有变化的尺寸。在一些示例中，载体部件的长度的范围从1mm至50mm，诸如5mm至30mm且包括10mm至20mm。载体部件的外径可以改变，在一些示例中范围从1mm至30mm，诸如5mm至20mm且包括5mm至10mm。载体部件的内径也可以改变，范围从0.5mm至29.99mm，诸如3.0mm至19.99mm且包括3.0mm至9.99mm。载体部件的壁可以改变，只要壁足够厚以保持药物活性剂合成物，其中在一些示例中，壁厚度的范围从0.01mm至2mm，诸如0.01mm至0.2mm且包括0.01mm至0.1mm。载体部件的尺寸可以按期望为恒定的或可变的。例如，内径可以沿着胶囊的长度为恒定的或者可以改变。
本发明的载体部件，诸如局部胶囊构造的载体部件，可以利用任何方便的规约由任何方便的材料制成。可制成载体部件的所关心的材料包括在常规的药物胶囊剂中使用的药物方面可接受的聚合材料。材料可以为透明或不透明的，并且可以按期望为彩色的。所关心的是既有刚性又有弹性的材料。
可制成本发明的载体部件的适当的聚合物包括但不限于：明胶、聚乙烯醇(PVA)；天然多糖和合成多糖，包括支链淀粉、角叉菜胶、黄原凝胶、壳聚糖琼脂胶、和纤维素材料，诸如羧甲基纤维素、羟丙基甲基纤维素(HPMC)、甲基纤维素、羟乙基纤维素、羟乙基甲基纤维素、羟丙基纤维素；聚乙二醇(PEG)、聚氧化乙烯(PEO)、PEG和PEO的混合物；丙烯酸和甲基丙烯酸基聚合物，诸如EUDRAGIT RTM、EUDRAGIT LTM和/或EUDRAGITSTM甲基丙烯酸聚合物、EUDRAGIT RLTM和/或EUDRAGIT RSTM甲基丙烯酸铵共聚物；聚维酮(聚乙烯吡咯烷酮)、聚糖酵解甘油酯(诸如GELUCIRE 44/14TM、GELUCIRE 50/02TM、GELUCIRE50/13TM和GELUCIRE 53/10TM聚合物)；羧基乙烯基聚合物(诸如CARBOPOLTM聚合物)；聚氧乙烯-聚氧丙烯共聚物(诸如POLOXAMER188TM聚合物)等。
载体部件的表面可以为平滑的、或者包括以任何图案布置的彩斑和/或槽。根据期望，载体部件具有隔室或隔区。载体部件可以具有多个隔室，以使得各隔室具有不同的活性剂释放特性或者包含不同的药物活性剂合成物，例如如美国专利No.4,738,724、No.5,672,359和No.5,443,461中描述的；这些申请的内容经引用并入本文中。
载体部件可以利用任何方便的规约制成，包括模塑成型等。所关心的制造规约包括但不限于美国专利No.5,705,189、No.4,576,284、No.4,591,475、No.4,655,840、No.4,738,724、No.4,738,817和No.4,790,881中描述的那些；这些申请的内容经引用并入本文中。替代地，载体部件可以从商业卖主获得，诸如Whitsett NC的Qualicaps有限公司。
在本发明的方法中，载体部件可以填充有各种不同类型的药物活性剂合成物。用于填充载体部件的规约可以根据药物活性剂合成物的性质而改变。例如，可以手动方式、利用自动装置、或手动方式和自动装置的组合方式，将诸如液体和固体(作为可流动固体的示施例的粒剂合成物和小球体合成物)的可流动合成物灌注进载体部件的内部空间中，从而用药物活性剂合成物填充载体部件。可再次以手动方式、利用自动装置、或手动方式和自动装置的组合方式，将诸如药片或胶囊的非流动固体定位到载体部件的内部容积的内部，从而填充载体部件。
如上所述，药物活性剂合成物可以为固体或液体合成物。所关心的固体合成物包括但不限于：粉末、例如珠或小球体形式的丸剂、包覆的粒剂和药片。所关心的液体合成物可以依据例如粘度、颜色等而变化。本发明的药物活性剂合成物包括或者单独或者与赋形剂结合的药物活性剂，其中赋形剂可包括一个或多个不同的组分，诸如填充剂、粘合剂、着色剂等。
如本文所使用的，术语“活性剂”包括在与诸如人的活体接触时产生例如有益或有用结果的生理结果的任何化合物。活性剂可与诸如填充剂、粘合剂、着色剂等这样的赋形剂组分区分开。活性剂可以为能够在活体对象中调节生物过程的任何分子。在一些示例中，活性剂可以为在疾病的诊断、治疗或预防中使用的物质或者作为药物的组分。所关心的宽泛种类的活性剂包括但不限于：心血管剂；止痛剂，例如镇痛剂、麻醉剂、消炎剂等；神经作用剂；化学治疗(例如，抗肿瘤)剂等。在作为WO 2006/116718公布的PCT申请序列No.US2006/016370中进一步公开了所关心的活性剂，该申请的内容经引用并入本文中。
药物活性剂合成物可以进一步包括如上所述的赋形剂组分。赋形剂组分可以包括一个或多个成分，所述成分包括但不限于填充剂、粘合剂、崩解剂、着色剂等。在作为WO2006/116718公布的PCT申请序列No.US2006/016370中进一步公开了所关心的赋形剂组分，该申请的内容经引用并入本文中。可在Remington’s Pharmaceutical Sciences，Mace Publishing Company，Philadelphia，Pa.，17th ed.(1985)中找到可在本发明的合成物中存在的组分的另外公开。
在一些示例中，方法可包括提供与载体组件中的活性剂合成物分离的填充剂合成物。例如，在一些示例中，载体部件填充有药物活性剂合成物和不同的填充剂合成物二者，其中填充剂合成物可被包括进以用于各种不同的用途。所关心的一类填充剂合成物是为药剂合成物添加比胃液密度大的密度的填充剂合成物。因此，所关心的填充剂合成物是为药剂合成物添加了0.8或更大的密度的填充剂合成物，诸如1.0或更大且包括1.2或更大的密度。任何方便的材料可以用作填充剂合成物，包括上文描述为赋形剂组分的材料。
还可以包括填充剂，以填充当诸如可吸收事件标记符(IEM，也称为离子发射模块)识别器的装置或识别器放置到载体部件的内部时存在的任何空隙。药剂的识别器部件提供了多个优点。识别器的存在使得可以监测给药的确切时间和频率以及病人的反应。可利用本发明的方法和药剂获得的该信息能够用于许多设定，诸如例如提高临床研究的总体质量和精度。利用该信息，可易于识别出临床试验中遵守治疗给药方案的成员且排除不遵守治疗给药方案的成员，从而获得与给定的活性剂的功效有关的更精确的数据。该信息还可以与各种类型的生理数据组合，从而获得与给定活性剂的效果有关的更综合的信息。
本发明的方法还由药剂师使用，即使所关心活性剂的原来制造商不提供包括IEM的药剂，药剂师也可制备出包括IEM的为病人定制的药剂。IEM是尺寸设计为可吸收的且包括导电控制模块和在与导电流体接触时完成工作的局部电源的装置。由于IEM的尺寸设计为可吸收的，因此IEM的尺寸设计为使得它们可放置于人的口中且被吞咽。在一些示例中，本发明的IEM具有30mm或更小的最长尺寸，诸如20mm或更小，包括5mm或更小。因此，当前可获得的任何药剂合成物均可与利用本发明的方法和部件的IEM相关联。
在将药剂活性剂合成物(和按期望任意任选的填充剂合成物)放置到载体部件的内部容积中之后，然后用封盖密封所生成的经充填后的载体部件。封盖是这样一种结构，其构造为以密封关系与载体部件的敞开端配合，使得当封盖与载体部件的敞开端联接时载体部件的内部容积及其内含物(药剂活性剂合成物)被密封于由载体和封盖限定的药剂结构的外部环境，使得气体和液体可不易于穿经药剂结构的外部环境和内部环境之间。封盖可由任何适当的材料制成，包括上文结合载体部件描述的材料。在一些示例中，封盖由微晶纤维素、交联羧甲基纤维素钠和硬脂酸镁制成。
本发明的封盖包括一个或多个IEM识别器。上述一个或多个IEM可以存在于封盖的各个不同位置处，包括内部位置和外部位置。内部位置包括构造为接收IEM的限定在封盖的内部的区域。外部位置包括外表面和内表面。封盖的外表面是当封盖与载体部件处于密封关系时朝向封盖的外部环境的那些表面。外表面可以按期望为封盖的侧表面或封盖的顶表面。封盖的内表面为当封盖与载体部件处于密封关系时朝向由载体部件和封盖限定的内部容积的那些表面。给定的封盖可包括单个IEM或者两个或多个IEM，诸如三个或更多的可吸收事件标识符。
上述一个或多个IEM与封盖稳定地联接。因此，利用例如粘合剂，将识别器固定到封盖的位置，诸如封盖的外表面。所关心的粘合剂包括但不限于：糖和纤维素粘合剂、诸如玉米醇溶蛋白或酪蛋白的蛋白质粘合剂、有机硅粘合剂、包括丙烯酸粘合剂和甲基丙烯酸粘合剂的聚合粘合剂、虫胶等。
所关心的IEM是通过在IEM与目标生理位置(或多个位置)接触时生成流过诸如导电流体等导电环境的唯一电流签名，来传送信息的识别器。IEM可根据本发明的特定实施方式和期望应用而改变，只要IEM在与诸如胃液或肠液的目标生理位置接触时被激活(接通)即可。因此，IEM可以是当在目标部位被激活时，例如当IEM接触目标身体部位时，生成用信息编码的唯一电流签名的识别器。IEM可以为能够在激活之后提供可检测信号的任何部件或装置。根据本发明各方面的IEM包括用于生成唯一电流签名的控制单元。IEM可以配置为一旦合成物与生理目标部位形成接触就生成唯一电流签名。根据实施方式，目标生理部位或位置可以改变，其中所关心的代表性目标生理部位包括但不限于：胃肠道中的位置，诸如口、食道、胃、小肠、大肠等。IEM可以配置为无论目标部位的特定合成物如何，在与例如胃液等目标部位处的流体接触时被激活。根据期望，识别器可以配置为在合成物与目标生理部位接触之后通过询问而被激活。IEM可以配置为在特定时间段之后被激活，其中在特定时间段之后到达目标部位。
根据特殊应用的需要，从IEM获得的信息可以为属类的，以使信息仅识别合成物已接触到目标部位。替代地，信息可以为唯一的，所述信息以某方式唯一地识别出在批量药剂中来自一组或多个不同标识符的特定IEM已接触到目标生理部位。因此，IEM可以为当与批量药剂一起使用时、发射不能够与该批量中的任何其它药剂成员的IEM发射的电流签名区分开的电流签名的IEM。替代地，该批量中的各IEM可以发射至少相对于该批量中的所有其它IEM而言唯一的信号。在这些示例中，该批量中的各IEM生成唯一识别出那个相对于该批量中所有其它IEM特定的IEM的电流签名。IEM可以发射作为全世界唯一电流签名的唯一电流签名(其中，该电流签名可以相似于人类指纹，人类指纹与任何其他个体的任何其它指纹区分开，且因此在全世界级别上唯一地识别出个体)。电流签名可直接传送与给定事件有关的信息、或者提供识别码，识别码可用于从数据库即将识别码与合成物链接的数据库中获取与事件有关的信息。
IEM的电流生成周期的持续时间可依据本发明的教导而改变，从0.1微秒到48小时或更长，诸如从0.1微秒到24小时或更长，诸如从0.1微秒到4小时或更长，诸如从1秒到4小时，包括从1分钟到10分钟。根据给定的实施方式，IEM可一次生成在电流签名中编码的相同信息；替代地，IEM可以配置为两次或多次生成具有相同信息(完全相同)的电流签名，其中离散的完全相同的电流签名的收集可统称为冗余信号。
除了生成唯一电流签名之外，依据本发明的其它方面，IEM可配置为生成各种不同类型的信号，包括但不限于：RF(射频)信号、磁信号、声音信号等。
IEM可以依据特定实施方式和合成物的期望应用而改变，只要IEM在与诸如胃的目标生理位置接触时被激活(即，接通)即可。IEM包括导电控制单元和通过诸如胃酸等导电流体完成工作的局部电源。所关心的不同类型的IEM的示例包括但不限于在如下申请中描述的那些示例：公布为WO/2006/116718的PCT申请序列no.PCT/US2006/016370；公布为WO/2008/052136的PCT申请序列no.PCT/US2007/082563；公布为WO/2008/063626的PCT申请序列no.PCT/US2007/024225；公布为WO/2008/066617的PCT申请序列no.PCT/US2007/022257；公布为WO/2008/095183的PCT申请序列no.PCT/US2008/052845；公布为WO/2008/101107的PCT申请序列no.PCT/US2008/053999；公布为WO/2008/112577的PCT申请序列no.PCT/US2008/056296；公布为WO/2008/112578的PCT申请序列no.PCT/US2008/056299；PCT申请序列no.PCT/US2008/077753；以及于2009年9月21日提交的美国专利申请序列no.12/564,017，这些申请的内容经引用并入本文中。
封盖可以具有各种不同的构造，只要封盖构造为当与载体部件的敞开端联接时密封载体部件的敞开端即可。封盖可具有各种不同构造，这些构造容许当封盖与载体部件的敞开端联接时密封载体部件的敞开端。在一些示例中，封盖具有互锁元件，所述互锁元件与载体部件的敞开端的配合元件协同工作以密封载体部件的敞开端。互锁元件的示例为螺纹和卡合配合元件。替代，封盖可以具有构造为压配到载体的内部且密封载体部件的内含物的区域或端部。这种构造的示例是，封盖具有由刚性材料制成的端部，其中端部的构造稍大于载体部件的敞开端。在载体部件的敞开端由弹性体材料制成的情况下，可通过拉伸载体的敞开端将封盖的刚性端部压配到载体的敞开端中。当任何拉伸力从载体的敞开端移除时，载体的敞开端随后将以密封关系与刚性端部接合。替代地，封盖可包括具有一定量柔顺度的可压缩端部。该柔顺度足以使封盖具有如下能力，即通过压缩可压缩端以生成被压缩端、将封盖的被压缩端放置到载体部件的敞开端中、然后移除压缩力，而将封盖的柔顺端压配到载体部件的敞开端的内部。当由于压缩力的移除而使得被压缩端膨胀时，被压缩端以密封关系与载体部件的敞开端的构造相贴合以将载体部件的内含物密封在载体部件内部。
可以多种不同的方式设置带有可压缩端部的封盖。一类可压缩端部是由可压缩材料制成的端部。所关心的可压缩材料是柔顺的。替代地，可压缩端部可以包括使可压缩端部具有可压缩性的一个或多个切除部。
按照期望，封盖可借助于粘合剂固定至载体部件的敞开端，其中上文提供了适当的粘合剂的示例。因此，封盖可胶粘到载体部件的敞开端上，以便于密封载体部件的敞开端。
在一些示例中，通路或类似的结构设置在载体和/或封盖中，这有利于药剂形式的液体渗透、载体部件的溶解和/或降低药剂形式的浮力。当存在时，这些孔的直径的范围可从10-3mm至5mm，诸如直径为0.1mm至2mm。
现在参见图1A和图2A，药剂载体系统10包括封盖20和壳体或外壳50。系统10的壳体50限定腔，且包括敞开端60和封闭端70。封闭端70具有局部刨削的基部，侧壁从所述基部沿向上方向延伸，以在敞开端60处以敞开口部结束从而在其中限定腔。在其它构造中，封闭端70还可为圆形结构，诸如半球形端壁，并且具有圆锥形构造等。
系统10包括在壳体50的内壁上的接合区域65。当封盖20以足以生成壳体50和封盖20之间的密封的方式插入到壳体50的敞开端60中时，接合区域65可与封盖20接合。封盖20和壳体50的尺寸选择为使得在封盖20的外壁和壳体50的接合区域65的内壁之间存在接触。
如上所述，系统10可填充有药物活性剂合成物和/或填充剂合成物。依据本发明的一个方面，系统10填充有药片形式的药物活性剂合成物和两个填充剂合成物。因此，壳体50填充有药物活性剂药片30以及两个填充剂合成物35和37。尽管在由壳体50限定的腔内按特定次序显示，本发明的范围不受药片30以及填充剂合成物35和37的相对位置或次序的限制。例如，药片30可位于如图1A所示的填充剂合成物37的位置处。另外，药片30以及填充剂合成物35和37的取向可翻转以更好地容纳系统10的组件，如图1B和图2B中所示，并且本发明的范围不受此限制。填充剂合成物35和37中的至少一个由使得整个系统10具有密度的材料制成。依据本发明的一个方面，所述密度可大于系统10进入或被导入的环境诸如胃液的密度。因此，填充剂合成物35和37中的任一个可用于改变系统10的浮力；另一填充剂合成物可用于防止药片30和另一填充剂合成物在由壳体50限定的腔内移动。依据本发明的另一方面，两个填充剂合成物均可用于改变系统10的浮力。依据本发明的教导，填充剂合成物中的任一个可由药剂代替，使得系统10包括在不同时间或同时释放到周围环境中的两个(或多个？)不同的药物活性剂。
现在参见图1A和图1B，在组装系统10时，诸如药片30的药物活性剂、以及两个填充剂合成物35和37位于壳体50的内部，如图所示。该定位步骤可通过手动方式或通过自动方法来实现，自动方法诸如通过使用组装机器、远程机器人或其它自动化装置。在将药片30以及填充剂合成物35和37放置到壳体50中之后，壳体50的敞开端60由封盖20密封以密封系统10。用封盖20密封壳体50的敞开端60可通过手动方式或通过自动方法来实现，自动方法诸如通过使用组装机器、远程机器人或其它自动化装置。
如图1A和图2A所示，包含药片30以及填充剂合成物35和37的由壳体50限定的腔用封盖20密封。封盖20可压配到壳体50的敞开端60的内部。依据本发明的另一方面，封盖20可胶粘到接合区域65。
现在参见图1A和图2A，封盖20包括在其顶部外表面上的装置40，诸如IEM。装置40通过利用适当的固定方法固定到封盖20的上表面。例如，依据本发明的一个方面，装置40利用适当的粘合剂胶粘到封盖20。替代地，如图1B和图2B中所示，装置40可固定到封盖20的底部内表面，使得当封盖20位于壳体50的腔内时，装置40被密封在壳体50的腔内并防止装置40与系统10被导入其中的周围环境接触，直到封盖20从壳体50释放为止。
依据本发明的另一方面，装置40包括如PCT申请序列no.PCT/US2008/077753中描述的虚拟偶极元件；该申请的内容经引用并入本文。依据本发明的另一方面，装置40可以是不可见的。
现在参见图1A和图2A，封盖20包括配合到壳体50的敞开端60中的插入部80，如上文所述。插入部80与装置40位于其上的表面相对。如图所示，插入部80限定至少一个切除部90，切除部90允许插入部80配合到敞开端60的内部。敞开端60可以是可延展的，以便于拉伸且压配到插入部80上，并且提供紧固配合。因此，当用于将插入部80密封到敞开端60中时，封盖20可被挤压以配合到壳体50的敞开端60中。
现在参考图1B和图2B，封盖20包括配合到壳体50的敞开端60中的插入部80，如上文所述。插入部80定位为紧靠近封盖20的底表面。封盖20的底表面形成为接收定位到底表面且紧固到底表面上的装置40的形状。如图所示，插入部80限定多个切除部90，这些切除部90允许插入部80配合到敞开端60的内部。然而，本发明的范围不受封盖20的底表面上切除部的形状或数量的限制。敞开端60可以是可延展的，以便于拉伸且压配到插入部80上，并且提供紧固配合。替代地并且依据本发明的另一方面，敞开端60可以为刚性的且成锥形(未示出)以配合地接收封盖20的锥形插入部(未示出)，其中敞开端60的锥形部和封盖20的锥形插入部胶粘到一起。因此，封盖20可被挤压且胶粘到壳体50的敞开端60中，以便将封盖20固定到壳体50上。
现在参见图3A、图3B和图3C，封盖20包括插入部80。依据本发明的一个方面，插入部80限定四个槽道或切除部92、94、96和98。每个切除部具有近月牙形，如图所示。然而，切除部92、94、96和98可具有便于将封盖20配合到敞开端60中的任何适当的形状，诸如多边形形状。如图所示，封盖20的插入部80包括周向环形斜角突棱。
在一些示例中，固定至壳体50的端部的封盖20可由顶盖部件覆盖。顶盖部件可由多种材料制成，诸如为载体部件采用的材料中的任一种。顶盖可由不透明材料制成，以便于遮挡装置40的存在以及防止在封装和处理过程中与周围环境接触。顶盖部件可为弹性体，例如以提供紧固配合到与载体部件处于密封关系的封盖上。
现在参见图4，依据本发明的另一方面，药剂系统130包括顶盖132。药剂系统130包括由封盖134密封的载体部件140。封盖134包括在其外表面上的装置136，诸如电流签名生成装置或IEM。位于封盖134上方的是顶盖132。顶盖132固定至载体部件140，如图所示；这防止一旦药剂系统130被吸收，装置136和导电流体之间接触。一旦顶盖132从载体部件140释放，装置136与周围环境形成接触，并且如果该环境包括诸如胃液的导电流体，那么装置136被激活且生成电流签名，所述电流签名能够被检测出且被解码以获取信息。
按照期望，准备药剂递送系统的方法可进一步包括制备安慰剂药剂。安慰剂药剂可以与制备包括药物活性剂的药剂类似的方式制备，除了药物活性剂不放置到载体部件的内部之外。替代地，例如如上所述，缺少活性剂的赋形剂合成物放置到载体部件的内部、然后用封盖进行密封。制备安慰剂的方法包括在临床试验中药剂要采用的方法。
依据本发明的又一方面，制备药剂递送系统的方法可进一步包括例如单独地或与填充剂结合的方式制备在载体内具有装置的药剂。在其它应用中，这些方面可便于经由唯一电流签名的生成来标记药剂递送系统的吸收事件。
依据本发明的另一方面，两个不同的药剂可放置在壳体50内，且由填充剂合成物分隔开。在两个不同的药物制剂必须混合到溶液中以变得活性的的示例中，这种物理分离是有益的。因此，在壳体50溶解时，两个单独的药物制剂释放到诸如胃液的周围流体中。这使得两个之前分离的药物制剂形成接触且结合，从而使得两个不同的药物制剂精确地递送到目标部位处且使两个不同的药剂在目标部位处结合。
本发明的多个方面进一步包括使用根据如上所述的方法生成的药剂的方法。一般地，本发明的方法包括例如通过使受治疗者咽下本发明的药剂，将一个或多个药剂给送到受治疗者。药剂可给送到各种不同类型的受治疗者。通常这些受治疗者是“哺乳类”或“哺乳动物”，其中这些术语宽泛地用于描述在类哺乳类内的生物体，依次包括食肉动物(例如狗和猫)、啮齿类(例如，老鼠、天竺鼠和鼠)，以及灵长类(例如人类、黑猩猩和猴子)。在咽下之后，唯一电流签名由IEM生成且借助于例如接收器而被检测，所述接收器诸如在如下PCT申请中描述的接收器：公布为WO/2006/116718的PCT申请序列no.PCT/US2006/016370；公布为WO/2008/052136的PCT申请序列no.PCT/US2007/082563；公布为WO/2008/063626的PCT申请序列no.PCT/US2007/024225；公布为WO/2008/066617的PCT申请序列no.PCT/US2007/022257；公布为WO/2008/095183的PCT申请序列no.PCT/US2008/052845；公布为WO/2008/101107的PCT申请序列no.PCT/US2008/053999；公布为WO/2008/112577的PCT申请序列no.PCT/US2008/056296；公布为WO/2008/112578的PCT申请序列no.PCT/US2008/056299；PCT申请序列no.PCT/US2008/077753；于2009年10月13日提交的美国专利申请序列no.61/251,088；以及于2009年12月15日提交的PCT专利申请序列no.PCT/US2009/068128，上述各申请的内容经引用并入本文中。
例如如上所述的制备药剂且将药剂给送到受治疗者的方法可用于各种不同的应用中。所关心的一个应用是将药剂的识别器用作IEM。本发明的药剂可用于治疗药物应用和非治疗药物应用二者，诸如在如下申请中描述的：公布为WO/2006/116718的PCT申请序列no.PCT/US2006/016370；公布为WO/2008/052136的PCT申请序列no.PCT/US2007/082563；公布为WO/2008/063626的PCT申请序列no.PCT/US2007/024225；公布为WO/2008/066617的PCT申请序列no.PCT/US2007/022257；公布为WO/2008/095183的PCT申请序列no.PCT/US2008/052845；公布为WO/2008/101107的PCT申请序列no.PCT/US2008/053999；公布为WO/2008/112577的PCT申请序列no.PCT/US2008/056296；公布为WO/2008/112578的PCT申请序列no.PCT/US2008/056299；以及PCT申请序列no.PCT/US2008/077753；上述申请的内容经引用并入本文中。
所关心的应用包括自动检测和识别实际递送到身体中的药剂，可通过如下过程完成：(1)监测病人对处方治疗给药方案的坚持；(2)基于病人的坚持调整治疗给药方案；(3)在临床试验中监测病人的坚持；(4)监测受控物质的使用等。在如下申请中更加详细地说明这些不同的示例性应用中的每个：公布为WO/2006/116718的PCT申请序列no.PCT/US2006/016370；公布为WO/2008/052136的PCT申请序列no.PCT/US2007/082563；公布为WO/2008/063626的PCT申请序列no.PCT/US2007/024225；公布为WO/2008/066617的PCT申请序列no.PCT/US2007/022257；公布为WO/2008/095183的PCT申请序列no.PCT/US2008/052845；公布为WO/2008/101107的PCT申请序列no.PCT/US2008/053999；公布为WO/2008/112577的PCT申请序列no.PCT/US2008/056296；公布为WO/2008/112578的PCT申请序列no.PCT/US2008/056299；以及PCT申请序列no.PCT/US2008/077753；上述申请的内容经引用并入本文中。
在一些实施方式中，在临床试验中采用了制成本发明的药剂的方法。实施本发明的方法和合成物包括多病人研究的临床试验，使得可为新的药物活性剂收集安全性和功效数据。临床试验的示例包括这样的研究：最初调查者使健康志愿者和/或病人参加小型试验性的研究，随后是对病人进行较大规模的研究，这些研究通常将新型产品与当前处方治疗进行比较。此外，临床试验还可以将所关心的活性剂与安慰剂合成物进行比较。在这些示例中，安慰剂可以与制成本发明的药剂的方法类似的方式制成，唯一的区别在于，药物活性剂合成物不密封在载体部件中。由于在给定临床试验中收集到积极的安全性和功效数据，可增加病人的数量。临床试验的规模可从一个国家的单个中心变化到多个国家的多中心试验。
借助于根据本发明制备的药剂进行临床试验提供了多个优点。一个优点是，临床试验管理者(正在操控临床试验的实体)可使用标准的载体部件和封盖，且按照给定药物活性剂合成物的需要对这些载体部件和封盖进行定制。
如上所述，还提供了包括本发明的一个或多个药剂的系统。除了本发明的药剂之外，依据本发明的教导，系统可包括与身体相关联的信号接收器，信号接收器用于检测电压电位(voltage potential)的变化，电压电位代表根据本发明教导从药剂载体接收的编码信息。所关心的与身体相关联的接收器包括在公布为WO/2008/095183的PCT/US2008/052845、和公布为WO/2006/116718的PCT/US2006/016370中描述的接收器；这些申请的内容经引用并入本文中。如这些并入的申请中描述的，接收器可植入病人的身体或在病人的身体表面上。上述系统可进一步包括附加的数据中继和/或处理部件，诸如无线通信装置(诸如移动电话)；可用于计算机和信息系统中的数据处理器等。
还提供了用于实施主题方法的套件。套件可包括本发明的一个或多个载体部件和相关封盖，如上文所述的。装备套件的载体部件和相关封盖，以接收待被密封到其中的一个或多个药物活性剂合成物的药剂；诸如与方便套件单独提供的药物活性剂合成物。按照期望，套件还可以包括一个或多个填充剂合成物。给定套件可以包括足够的载体部件和封盖，以制成一个或多个药剂，包括5个或更多个，诸如50个或更多个、100个或更多个、1000个或更多个、5000个或更多个、或10000个或更多个。
主题套件还可以包括如何利用套件的部件实施主题方法的指令。指令可记录在适当的记录介质或基底上。例如，指令可印制在基底上，诸如纸张或塑料等。因此，在为套件的容器或套件的部件(即，与封装或子封装相关联的)打标签等时，指令可作为封装插入件存在于套件中。在其它的实施方式中，指令作为存在于诸如CD-ROM、软磁盘等适当的计算机可读存储介质上的电子存储数据文件而存在。在另外的其它实施方式中，实际的指令不存在于套件中，而是提供用于经由例如因特网从远程源获得指令的装置。该实施方式的示例是包括网络地址的套件，通过所述网络地址可以查看指令、和/或可以从所述网络地址下载指令。与指令相同，用于获得指令的手段记录到适当的基底上。
主题套件的一些或全部部件可以适当封装方式进行封装以保持无菌。按照期望，套件的部件封装在套件容纳元件中，以形成单个易于处理的单元，其中套件容纳元件可以为盒或类似结构，并且可以为气密性容器或者可不为气密性容器。
应当理解的是，本发明不限于描述的特定实施方式，因此可以改变。还可以理解的是，本文使用的术语仅是为了说明特定实施方式的目的，并且无意限制，因为本发明的范围仅由随附的权利要求限定。
在提供数值范围的情况下，可以理解，除非上下文清晰说明，该范围的上下限之间的每个中间值以及所阐述范围内的任何其它所陈述的值或中间值均包括在本发明中，其中下限精确到十分位。这些较小范围的上限和下限，在任何特别排除阐述范围内的极限值的条件下，可独立地包括在较小范围内并也包括在本发明内。在所阐述范围包括这些极限值的一个或两个的情况下，将这些所包括的极限值的任一个或两个排除的范围也包括在本发明内。
除非另外限定，本文所用的所有科技术语的含义与本发明所属领域的技术人员通常理解的含义相同。虽然与本文所述的方法和材料相似或等同的任何方法和材料也可用于实施或测试本发明，但现在描述代表性例示的方法和材料。
在该说明书中引用的所有公开文献和专利经引用并入本文中，就像每个单独的公开文献或专利被特别地和单独地说明从而经引用并入，并且经引用并入本文以公开和描述与所引用的公开文献相关的方法和/或材料。对任何公开文献的引用是针对在本发明申请日之前的公开内容，并且不应该理解为承认本发明因先前发明而不是先于这种公开文献。此外，所提供的公开文献的日期可能与可能需要单独确认实际公开文献的日期不同。
注意到，如本文所用的以及在所附权利要求中，单数形式的“一”、“一个”以及“该”包括复数事物，除非上下文另外清晰地说明。另外注意，权利要求可撰写成排除任何选择性元素。同样，这种阐述意图用作结合权利要求元素叙述的诸如“仅”、“只”等这种排他性术语使用、或者“否定”限制的使用的前提基础。
本文呈现出某些范围，这些范围以前面用术语“约”修饰的数值表示。术语“约”在本文中用于为“约”在前面进行修饰的精确数字、以及接近或近似于“约”在前面进行修饰的数字，提供文字支持。在判定数字是否接近或近似于特别列举的数字时，接近或近似的未引用数字可以为这样的数字：在该数字出现的上下文中，该数字提供了与特别列举数字的大致等同。
在本领域技术人员在研读该公开内容时，本文所述的和图示的单独实施方式中的每一个具有分离的部件和结构，在不脱离本发明范围或主旨的情况下，这些分离的部件和特征可易于与其它若干实施方式中的任一个中的结构分开或结合。任何引述的方法均可按照引用事例的顺序、或按照逻辑上可能的任何其它顺序实施。
尽管为了清晰理解的目的已经通过图示和示例的方式在一定详细程度上描述了前述的发明，对于本领域普通技术人员显而易见的是，依据本发明的教导，可以在不脱离所附权利要求的主旨或范围的情况下，可对本发明进行某些变化和变型。

Claims (25)

1.一种用于跟踪递送参数的药剂递送系统，所述系统包括：
载体壳体，载体壳体具有封闭端和敞开端，其中所述载体壳体限定腔；
药剂，药剂位于所述载体壳体的所述腔内；以及
封盖，封盖包括顶端和底端，其中所述底端包括密封部，所述密封部与所述载体壳体的所述敞开端物理连通，以密封容纳所述药剂的所述腔；以及
与所述系统相关联的装置，其中所述装置生成用于传送信息的可识别电流签名。
2.如权利要求1所述的系统，其中，所述装置固定至所述封盖的顶部，使得在所述载体壳体与周围环境形成接触时，所述装置能够与周围环境形成接触。
3.如权利要求1所述的系统，其中，所述密封部限定至少一个槽道，所述槽道使得所述封盖能被压配到所述载体壳体的所述敞开端中。
4.如权利要求1所述的系统，其中，所述装置固定至所述底端，使得在所述系统被吸收并且所述封盖与所述载体壳体分开之后，所述装置与周围环境形成接触。
5.如权利要求1所述的系统，其中，所述密封部利用粘合剂固定至所述载体壳体的所述敞开端。
6.如权利要求1所述的系统，其中，所述装置包括：
框架；
导电控制模块，导电控制模块固定到所述框架内，用于生成表示所述信息的所述可识别电流签名；
第一材料，第一材料固定至所述框架，且电耦合至所述导电控制模块；以及
第二材料，第二材料固定至所述框架，且电耦合至所述导电控制模块，
其中，所述第一材料和所述第二材料由非导电材料分隔开，且被选择为当与导电流体接触时产生电压电位。
7.一种药剂载体，包括：
壳体，壳体限定腔，其中所述壳体包括敞开端和封闭端；
用于改变所述载体的浮力的器械，所述器械位于所述壳体的所述腔内；
封盖，封盖包括顶端和底端，其中所述底端限定至少一个槽道，所述槽道用于将所述封盖配合到所述壳体的所述敞开端中，以密封所述腔的内含物；以及
电流控制装置，电流控制装置固定至所述封盖，且用于生成唯一电流签名，其中所述电流控制装置包括：
导电控制模块，导电控制模块固定在框架内，用于生成可识别电流签名；以及
局部电源，局部电源包括彼此绝缘的第一材料和第二材料，并且所述第一材料和所述第二材料中的每一个电耦合至所述导电控制模块，其中所述第一材料和所述第二材料固定至所述框架。
8.如权利要求7所述的载体，其中，当所述第一材料和所述第二材料通过与它们接触的导电流体电耦合时，所述电流控制装置的所述局部电源产生电压电位，并且所述电压电位用于激活所述导电控制模块以生成所述可识别电流签名。
9.如权利要求8所述的载体，其中，所述电流控制装置固定至所述封盖的所述顶端，以使大约在所述壳体与导电流体形成接触的同时所述电流控制装置与所述导电流体形成接触，并且因此所述电流控制装置在与所述导电流体接触时被激活。
10.如权利要求8所述的载体，其中，所述电流控制装置固定至所述封盖的所述顶端，并且其中，所述载体进一步包括位于所述封盖的所述顶端上方的顶盖，以使所述顶盖防止所述导电流体与所述电流控制装置接触，直到所述顶盖溶解为止，这使得在所述载体导入环境的时间与所述导电控制模块的激活之间存在延迟，且因此延迟了所述可识别电流签名的生成。
11.如权利要求8所述的载体，其中，所述电流控制装置固定至所述封盖的所述底端，以使在所述封盖与所述壳体分开之后，所述电流控制装置与周围环境形成接触，从而使所述电流控制装置延迟生成所述可识别电流签名。
12.如权利要求7所述的载体，其中，所述封盖包括位于所述底端处的锥形部，并且所述壳体包括位于所述敞开端处的锥形部，以使所述锥形部阳-阴配合且胶粘到一起，从而将所述封盖固定到所述壳体的所述敞开端中以密封所述腔。
13.如权利要求7所述的载体，其中，所述封盖以机械方式配合到所述壳体的所述敞开端以密封所述壳体的所述腔。
14.如权利要求7所述的载体，进一步包括位于所述壳体的所述腔内的药剂。
15.如权利要求7所述的载体，其中，所述器械具有使所述装置具有大于胃液的密度的密度的合成物。
16.一种用于提供与药剂产品的吸收相关联的信息的可吸收载体，所述载体包括：
可溶解壳体，壳体限定腔，其中所述壳体包括敞开端和封闭端，并且所述药剂产品能够位于由所述壳体限定的所述腔内；
封盖，封盖包括顶端和包含固定部的底端，其中所述固定部限定多个槽道，所述槽道使所述封盖插入到所述壳体的所述敞开端中；以及
电流签名生成装置，电流签名生成装置与所述载体相关联，用于生成表示与所述药剂产品的吸收相关联的所述信息的电流签名，其中所述装置包括：
框架；
导电控制模块，导电控制模块固定至所述框架，用于生成表示所述信息的所述电流签名；以及
局部电源，局部电源包括分别电耦合到所述导电控制模块的第一材料和第二材料，其中所述第一材料和所述第二材料固定至所述框架且由非导电材料分隔开，并且其中，当所述第一材料和所述第二材料通过与它们接触的导电流体电耦合时，所述局部电源产生电压电位，并且所述电压电位激活所述导电控制模块且因此激活所述装置。
17.如权利要求16所述的载体，其中，所述装置固定至所述封盖的所述顶端，以使所述装置大约在所述壳体接触所述导电流体的同时接触所述导电流体。
18.如权利要求16所述的载体，其中，所述装置位于所述封盖的所述顶端上，并且其中，所述载体进一步包括围绕所述封盖定位且固定至所述封盖的顶盖，以使得所述顶盖通过延迟所述装置和所述导电流体之间的接触而使所述装置的激活延迟、且因此使所述电流签名的生成延迟。
19.如权利要求16所述的载体，其中，所述装置固定至固定端的底部，以使得在所述壳体溶解到所述封盖被释放的程度之后所述装置与所述导电流体形成接触，从而使电流签名的生成延迟。
20.如权利要求16所述的载体，其中，所述装置放置到由所述壳体限定的所述腔内。
21.如权利要求16所述的载体，其中，所述载体进一步包括位于由所述壳体限定的所述腔内的填充剂合成物，以防止所述药剂产品和所述装置在由所述壳体限定的所述腔内运动。
22.如权利要求16所述的载体，进一步包括位于由所述壳体限定的所述腔内的浮力改变装置。
23.如权利要求16所述的载体，其中，所述固定部胶粘到所述壳体的所述敞开端中。
24.如权利要求16所述的载体，其中，所述固定部以机械方式固定到所述壳体的所述敞开端。
25.如权利要求16所述的载体，其中，所述固定部压配到所述壳体的所述敞开端。
CN201080004031.4A 2009-01-06 2010-01-05 药剂递送系统 Active CN102365084B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14286109P 2009-01-06 2009-01-06
US61/142,861 2009-01-06
PCT/US2010/020140 WO2010080764A2 (en) 2009-01-06 2010-01-05 Pharmaceutical dosages delivery system

Publications (2)

Publication Number Publication Date
CN102365084A true CN102365084A (zh) 2012-02-29
CN102365084B CN102365084B (zh) 2014-04-30

Family

ID=42317103

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080004031.4A Active CN102365084B (zh) 2009-01-06 2010-01-05 药剂递送系统

Country Status (13)

Country Link
US (2) US8597186B2 (zh)
EP (2) EP2385827B1 (zh)
JP (2) JP5785097B2 (zh)
KR (1) KR20110104079A (zh)
CN (1) CN102365084B (zh)
AU (1) AU2010203737B2 (zh)
CA (1) CA2750148C (zh)
HK (2) HK1165272A1 (zh)
IL (1) IL213687A (zh)
MY (1) MY153758A (zh)
SG (1) SG172847A1 (zh)
TW (2) TWI544917B (zh)
WO (1) WO2010080764A2 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110799328A (zh) * 2017-05-03 2020-02-14 罗马科基利安有限公司 用于旋转式片剂压机的压制物品的出口设备及具有出口设备的旋转式片剂压机

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US9198608B2 (en) * 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
CN101496042A (zh) 2006-05-02 2009-07-29 普罗秋斯生物医学公司 患者定制的治疗方案
JP5916277B2 (ja) 2006-10-25 2016-05-11 プロテウス デジタル ヘルス， インコーポレイテッド 摂取可能な制御活性化識別子
US8718193B2 (en) 2006-11-20 2014-05-06 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
MY165368A (en) 2007-02-01 2018-03-21 Proteus Digital Health Inc Ingestible event marker systems
EP3236524A1 (en) 2007-02-14 2017-10-25 Proteus Digital Health, Inc. In-body power source having high surface area electrode
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
WO2008112577A1 (en) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. In-body device having a multi-directional transmitter
US8540632B2 (en) 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
PT2192946T (pt) 2007-09-25 2022-11-17 Otsuka Pharma Co Ltd Dispositivo no corpo com amplificação de sinal dipolo virtual
DK2268261T3 (en) 2008-03-05 2017-08-28 Proteus Digital Health Inc Edible event markers with multi-mode communications and systems as well as methods for using them
SG10201702853UA (en) 2008-07-08 2017-06-29 Proteus Digital Health Inc Ingestible event marker data framework
EP2313003B1 (en) 2008-08-13 2016-08-03 Proteus Digital Health, Inc. Ingestible circuitry
MY153758A (en) * 2009-01-06 2015-03-13 Proteus Digital Health Inc Pharmaceutical dosages delivery system
SG172846A1 (en) 2009-01-06 2011-08-29 Proteus Biomedical Inc Ingestion-related biofeedback and personalized medical therapy method and system
WO2010111403A2 (en) 2009-03-25 2010-09-30 Proteus Biomedical, Inc. Probablistic pharmacokinetic and pharmacodynamic modeling
MX2011011506A (es) 2009-04-28 2012-05-08 Proteus Biomedical Inc Marcadores de eventos ingeribles altamente confiables y metodos para utilizar los mismos.
US9149423B2 (en) 2009-05-12 2015-10-06 Proteus Digital Health, Inc. Ingestible event markers comprising an ingestible component
TWI517050B (zh) 2009-11-04 2016-01-11 普羅托斯數位健康公司 供應鏈管理之系統
UA109424C2 (uk) 2009-12-02 2015-08-25 Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки
BR112012025650A2 (pt) 2010-04-07 2020-08-18 Proteus Digital Health, Inc. dispositivo ingerível miniatura
TWI557672B (zh) 2010-05-19 2016-11-11 波提亞斯數位康健公司 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置
EP2642983A4 (en) 2010-11-22 2014-03-12 Proteus Digital Health Inc DEVICE INGREABLE WITH PHARMACEUTICAL PRODUCT
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
RU2014106126A (ru) * 2011-07-21 2015-08-27 Протеус Диджитал Хелс, Инк. Устройство, система и способ мобильной связи
US9235683B2 (en) 2011-11-09 2016-01-12 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
US20130129869A1 (en) 2011-11-23 2013-05-23 Hooman Hafezi Compositions comprising a shelf-life stability component
US8752728B2 (en) 2012-03-26 2014-06-17 Orbital Innovations, Llc Portable, time-release dosage form dispensing assembly
AU2013293234B2 (en) 2012-07-23 2017-08-31 Otsuka Pharmaceutical Co., Ltd. Techniques for manufacturing ingestible event markers comprising an ingestible component
US11737896B2 (en) 2012-07-31 2023-08-29 Purdue Research Foundation Wirelessly-powered implantable EMG recording system
SG11201503027SA (en) 2012-10-18 2015-05-28 Proteus Digital Health Inc Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device
CN104994827B (zh) 2012-12-19 2019-11-08 大塚制药株式会社 医药片剂及其制造方法和制造装置
US11149123B2 (en) 2013-01-29 2021-10-19 Otsuka Pharmaceutical Co., Ltd. Highly-swellable polymeric films and compositions comprising the same
JP5941240B2 (ja) 2013-03-15 2016-06-29 プロテウス デジタル ヘルス， インコーポレイテッド 金属検出器装置、システム、および方法
EP3005281A4 (en) 2013-06-04 2017-06-28 Proteus Digital Health, Inc. System, apparatus and methods for data collection and assessing outcomes
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
GB2557895A (en) 2014-04-04 2018-07-04 Towerview Health Inc Apparatus and associated methods for tracking and increasing medication adherence for patients
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
USD787812S1 (en) 2015-10-06 2017-05-30 Towerview Health, Inc. Pillbox
USD787811S1 (en) 2015-10-06 2017-05-30 Towerview Health, Inc. Tray for a pillbox
TWI728155B (zh) * 2016-07-22 2021-05-21 日商大塚製藥股份有限公司 可攝食事件標示器之電磁感測及偵測
AU2017348094B2 (en) 2016-10-26 2022-10-13 Otsuka Pharmaceutical Co., Ltd. Methods for manufacturing capsules with ingestible event markers
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
EP3624778A4 (en) 2017-05-17 2021-03-10 Massachusetts Institute of Technology SELF-FIRING ARTICLES
CN108814536B (zh) * 2018-03-09 2020-10-09 中北大学 一种用于结肠诊查的可变径履带式机器人机构
FR3093419B1 (fr) 2019-03-08 2021-06-18 Univ Grenoble Alpes Composition et procédé associé de mesure de l’observance thérapeutique
KR102344420B1 (ko) * 2019-10-11 2021-12-29 원광대학교산학협력단 확장형 구조를 갖는 위체류 약물전달장치 및 이의 제조 방법
US11357705B2 (en) 2019-12-11 2022-06-14 TW3 Properties LLC Portable, reusable dispensing assembly having multiple operating modes
US11485568B2 (en) 2019-12-11 2022-11-01 TW3 Properties LLC Portable, reusable medication dispensing assembly which has communication capability to improve medication adherence
KR102426727B1 (ko) * 2020-04-17 2022-07-28 성균관대학교산학협력단 방출 속도 조절 경구용 약물 전달 장치 및 방출 속도 조절 경구용 약물 전달 장치의 제조 방법

Family Cites Families (656)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799802A (en) 1966-06-28 1974-03-26 F Schneble Plated through hole printed circuit boards
US3607788A (en) 1967-11-20 1971-09-21 Robert J Adolph Liquid electrode material
US3589943A (en) 1968-08-29 1971-06-29 Gen Electric Electrochemical battery
US3642008A (en) 1968-09-25 1972-02-15 Medical Plastics Inc Ground electrode and test circuit
US3679480A (en) 1969-05-08 1972-07-25 Dow Chemical Co Electrical cell assembly
US3682160A (en) 1969-10-16 1972-08-08 Matsushita Electric Ind Co Ltd Physiological signal transmitter for use inside the body
US3719183A (en) 1970-03-05 1973-03-06 H Schwartz Method for detecting blockage or insufficiency of pancreatic exocrine function
US3837339A (en) 1972-02-03 1974-09-24 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
US3828766A (en) 1972-08-14 1974-08-13 Jet Medical Prod Inc Disposable medical electrode
US3989050A (en) 1972-09-19 1976-11-02 Gilbert Buchalter Process for utilizing certain gel compositions for electrical stimulation
US3944064A (en) 1973-10-26 1976-03-16 Alza Corporation Self-monitored device for releasing agent at functional rate
US4106348A (en) 1974-02-20 1978-08-15 U.S. Philips Corporation Device for examination by means of ultrasonic vibrations
US3893111A (en) 1974-03-14 1975-07-01 Albert Albert F System and method for remote monitoring of animal temperature
US3967202A (en) 1974-07-25 1976-06-29 Northern Illinois Gas Company Data transmission system including an RF transponder for generating a broad spectrum of intelligence bearing sidebands
US4090752A (en) 1974-10-07 1978-05-23 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly
ZA755785B (en) 1974-10-07 1976-08-25 Baxter Laboratories Inc Diagnostic electrode assembly
US4077397A (en) 1974-10-07 1978-03-07 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly
US4062750A (en) 1974-12-18 1977-12-13 James Francis Butler Thin film electrochemical electrode and cell
US4017856A (en) 1976-03-10 1977-04-12 Westinghouse Electric Corporation Self-calibrating microwave transponder
US4055178A (en) 1976-03-10 1977-10-25 Harrigan Roy Major Drug delivery device for preventing contact of undissolved drug with the stomach lining
US4129125A (en) 1976-12-27 1978-12-12 Camin Research Corp. Patient monitoring system
GB1594214A (en) 1977-01-21 1981-07-30 Cardio Tech Body electrodes
US4082087A (en) 1977-02-07 1978-04-04 Isis Medical Instruments Body contact electrode structure for deriving electrical signals due to physiological activity
JPS5475284A (en) 1977-11-29 1979-06-15 Asahi Chemical Ind Threeeterminal magnetic reluctance effect element
US4239046A (en) 1978-09-21 1980-12-16 Ong Lincoln T Medical electrode
US4345588A (en) 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
US4269189A (en) 1979-07-09 1981-05-26 Consolidated Medical Equipment Inc. Skin conducting electrode assembly
DE2928477C3 (de) 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
US4331654A (en) 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4418697A (en) 1981-08-17 1983-12-06 Francine Tama Electrode attachment method
US4494950A (en) 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4655840A (en) 1982-03-26 1987-04-07 Warner-Lambert Company Hydrophilic polymer compositions for injection molding
EG16028A (en) 1982-03-26 1986-12-30 Warner Lambert Co Apparatus and method for molding capsules
US4790881A (en) 1982-03-26 1988-12-13 Warner-Lambert Company Molded hydrophilic polymer
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
US4576284A (en) 1983-12-02 1986-03-18 Warner-Lambert Company Closing of filled capsules
US4738724A (en) 1983-11-04 1988-04-19 Warner-Lambert Company Method for forming pharmaceutical capsules from starch compositions
US4738817A (en) 1983-11-17 1988-04-19 Warner-Lambert Company Method for forming pharmaceutical capsules from hydrophilic polymers
US4559950A (en) 1983-11-25 1985-12-24 Graphic Controls Corporation Disposable biomedical and diagnostic electrode
US5000957A (en) 1984-03-19 1991-03-19 Alza Corporation Dispenser comprising hydrophilic osmopolymer
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4654165A (en) 1985-04-16 1987-03-31 Micro Tracers, Inc. Microingredient containing tracer
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4763659A (en) 1985-08-21 1988-08-16 Spring Creek Institute, Inc. Dry electrode system for detection of biopotentials
US4669479A (en) 1985-08-21 1987-06-02 Spring Creek Institute, Inc. Dry electrode system for detection of biopotentials
US4635641A (en) 1985-10-16 1987-01-13 Murray Electronics Associates Limited Multi-element electrode
US4663250A (en) 1986-03-12 1987-05-05 Institute Of Gas Technology Reduction of electrode dissolution
US4725997A (en) 1986-08-22 1988-02-16 Aprex Corporation Contingent dosing device
US4784162A (en) 1986-09-23 1988-11-15 Advanced Medical Technologies Portable, multi-channel, physiological data monitoring system
US4896261A (en) 1986-11-24 1990-01-23 Motorola Inc. System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages using a doubly-linked list
US4876093A (en) 1987-07-02 1989-10-24 Alza Corporation Dispenser with dispersing member for delivering beneficial agent
DE3723310A1 (de) 1987-07-15 1989-01-26 John Urquhart Pharmazeutisches praeparat und verfahren zu seiner herstellung
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
CA1327838C (fr) 1988-06-13 1994-03-15 Fred Zacouto Dispositif implantable de protection contre les affections liees a la coagulation sanguine
US4975230A (en) 1988-06-17 1990-12-04 Vapor Technologies Inc. Method of making an open pore structure
US4844076A (en) 1988-08-26 1989-07-04 The Johns Hopkins University Ingestible size continuously transmitting temperature monitoring pill
EP0392032B1 (de) 1989-04-10 1995-01-25 Pacesetter AB Implantierbares medizinisches Gerät mit Mitteln zum telemetrischen Übertragen von Daten
CA2016517C (en) 1989-05-11 1999-01-12 Dale R. Shackle Solid state electrochemical cell having microroughened current collector
US5281287A (en) 1989-07-21 1994-01-25 Iomed, Inc. Method of making a hydratable bioelectrode
US4987897A (en) 1989-09-18 1991-01-29 Medtronic, Inc. Body bus medical device communication system
US6359872B1 (en) 1997-10-28 2002-03-19 Intermec Ip Corp. Wireless personal local area network
US6749122B1 (en) 1990-05-25 2004-06-15 Broadcom Corporation Multi-level hierarchial radio-frequency system communication system
US5167626A (en) * 1990-10-02 1992-12-01 Glaxo Inc. Medical capsule device actuated by radio-frequency (RF) signal
US5279607A (en) * 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5395366A (en) * 1991-05-30 1995-03-07 The State University Of New York Sampling capsule and process
US5176626A (en) 1992-01-15 1993-01-05 Wilson-Cook Medical, Inc. Indwelling stent
ES2155068T3 (es) 1992-04-03 2001-05-01 Micromedical Ind Ltd Sistema de supervision fisiologica.
US5263481A (en) 1992-05-21 1993-11-23 Jens Axelgaard Electrode system with disposable gel
US5283136A (en) 1992-06-03 1994-02-01 Ramot University Authority For Applied Research And Industrial Development Ltd. Rechargeable batteries
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5261402A (en) 1992-07-20 1993-11-16 Graphic Controls Corporation Snapless, tabless, disposable medical electrode with low profile
US5338625A (en) 1992-07-29 1994-08-16 Martin Marietta Energy Systems, Inc. Thin film battery and method for making same
US7758503B2 (en) 1997-01-27 2010-07-20 Lynn Lawrence A Microprocessor system for the analysis of physiologic and financial datasets
US5757326A (en) 1993-03-29 1998-05-26 Seiko Epson Corporation Slot antenna device and wireless apparatus employing the antenna device
WO1996010996A1 (en) 1993-07-21 1996-04-18 The University Of Kentucky Research Foundation A multicompartment hard capsule with control release properties
US5394882A (en) 1993-07-21 1995-03-07 Respironics, Inc. Physiological monitoring system
US5458141A (en) 1993-08-04 1995-10-17 Quinton Instrument Company Abrasive skin electrode
US5443461A (en) * 1993-08-31 1995-08-22 Alza Corporation Segmented device for simultaneous delivery of multiple beneficial agents
DE4329898A1 (de) 1993-09-04 1995-04-06 Marcus Dr Besson Kabelloses medizinisches Diagnose- und Überwachungsgerät
US6390088B1 (en) 1993-12-13 2002-05-21 Boehringer Ingelheim Kg Aerosol inhaler
US6231593B1 (en) 1994-03-21 2001-05-15 Dusa Pharmaceuticals, Inc. Patch, controller, and method for the photodynamic therapy of a dermal lesion
US5600548A (en) 1994-08-11 1997-02-04 Sundstrand Corporation DC content control for an inverter
IE70735B1 (en) 1994-08-15 1996-12-11 Elan Med Tech Orally administrable delivery device
DE9414065U1 (de) * 1994-08-31 1994-11-03 Roehm Gmbh Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen
IL111396A (en) 1994-10-25 1997-07-13 Ness Neuromuscular Electrical Stimulation Systems Ltd Electrode system
US5485841A (en) 1995-02-14 1996-01-23 Univ Mcgill Ultrasonic lung tissue assessment
US5778882A (en) 1995-02-24 1998-07-14 Brigham And Women's Hospital Health monitoring system
US6374670B1 (en) 1995-03-13 2002-04-23 University Of Washington Non-invasive gut motility monitor
US5845265A (en) 1995-04-26 1998-12-01 Mercexchange, L.L.C. Consignment nodes
US5645063A (en) 1995-06-05 1997-07-08 Quinton Instrument Company Skin electrode having multiple conductive center members
US5738708A (en) 1995-06-07 1998-04-14 The Regents Of The University Of California Office Of Technology Transfer Composite metal membrane
US5802467A (en) 1995-09-28 1998-09-01 Innovative Intelcom Industries Wireless and wired communications, command, control and sensing system for sound and/or data transmission and reception
US6076016A (en) 1995-10-19 2000-06-13 Feierbach; Gary F. Galvanic transdermal conduction communication system and method
GB9522872D0 (en) 1995-11-08 1996-01-10 Oxford Medical Ltd Improvements relating to physiological monitoring
US8092224B2 (en) 1995-11-22 2012-01-10 James A. Jorasch Systems and methods for improved health care compliance
SE9504258D0 (sv) 1995-11-28 1995-11-28 Pacesetter Ab Device and method for generating a synthesized ECG
US5596302A (en) 1996-01-17 1997-01-21 Lucent Technologies Inc. Ring oscillator using even numbers of differential stages with current mirrors
US5868136A (en) 1996-02-20 1999-02-09 Axelgaard Manufacturing Co. Ltd. Medical electrode
US20010044588A1 (en) 1996-02-22 2001-11-22 Mault James R. Monitoring system
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
WO1997036646A1 (fr) * 1996-04-01 1997-10-09 Valery Ivanovich Kobozev Stimulateur electrique des voies gastro-intestinales
US5864578A (en) 1996-04-29 1999-01-26 Golden Bridge Technology, Inc. Matched filter-based handoff method and apparatus
US5800421A (en) 1996-06-12 1998-09-01 Lemelson; Jerome H. Medical devices using electrosensitive gels
US6081734A (en) 1996-08-16 2000-06-27 Roche Diagnostics Gmbh Monitoring system for the regular intake of a medicament
HU228007B1 (en) 1996-08-29 2012-08-28 Jagotec Ag Tablet with controlled release of alfuzosine chlorydrate
US5792048A (en) 1996-09-03 1998-08-11 Schaefer; Guenter Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners
US5963132A (en) 1996-10-11 1999-10-05 Avid Indentification Systems, Inc. Encapsulated implantable transponder
US6364834B1 (en) 1996-11-13 2002-04-02 Criticare Systems, Inc. Method and system for remotely monitoring multiple medical parameters in an integrated medical monitoring system
US8734339B2 (en) 1996-12-16 2014-05-27 Ip Holdings, Inc. Electronic skin patch for real time monitoring of cardiac activity and personal health management
US5974124A (en) 1997-01-21 1999-10-26 Med Graph Method and system aiding medical diagnosis and treatment
US6122351A (en) 1997-01-21 2000-09-19 Med Graph, Inc. Method and system aiding medical diagnosis and treatment
ATE477746T1 (de) 1997-03-17 2010-09-15 Adidas Ag Informationsrückkopplungs system für physiologische signale
DE19717023C2 (de) 1997-04-23 2003-02-06 Micronas Gmbh Vorrichtung zum Behandeln von malignen, tumorösen Gewebebereichen
US5981166A (en) 1997-04-23 1999-11-09 Pharmaseq, Inc. Screening of soluble chemical compounds for their pharmacological properties utilizing transponders
US6288629B1 (en) 1997-05-23 2001-09-11 Intermec Ip Corp. Method of using write—ok flag for radio frequency (RF) transponders (RF Tags)
US5984875A (en) 1997-08-22 1999-11-16 Innotek Pet Products, Inc. Ingestible animal temperature sensor
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
US6099259A (en) 1998-01-26 2000-08-08 Bristol Compressors, Inc. Variable capacity compressor
US6097927A (en) 1998-01-27 2000-08-01 Symbix, Incorporated Active symbolic self design method and apparatus
US6038464A (en) 1998-02-09 2000-03-14 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7542878B2 (en) 1998-03-03 2009-06-02 Card Guard Scientific Survival Ltd. Personal health monitor and a method for health monitoring
US6141592A (en) 1998-03-06 2000-10-31 Intermedics Inc. Data transmission using a varying electric field
US6579231B1 (en) 1998-03-27 2003-06-17 Mci Communications Corporation Personal medical monitoring unit and system
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
DK1077634T3 (da) 1998-05-13 2003-11-24 Cygnus Therapeutic Systems Monitorering af fysiologiske analytter
US6477424B1 (en) 1998-06-19 2002-11-05 Medtronic, Inc. Medical management system integrated programming apparatus for communication with an implantable medical device
US6704602B2 (en) 1998-07-02 2004-03-09 Medtronic, Inc. Implanted medical device/external medical instrument communication utilizing surface electrodes
US7548787B2 (en) 2005-08-03 2009-06-16 Kamilo Feher Medical diagnostic and communication system
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US6333699B1 (en) 1998-08-28 2001-12-25 Marathon Oil Company Method and apparatus for determining position in a pipe
RU2226358C2 (ru) 1998-09-04 2004-04-10 Уолф Рисерч Пти. Лтд. Система медицинского имплантата
FI116957B (fi) 1998-10-29 2006-04-13 Nokia Corp Menetelmä langattoman laitteen ja elektroniikkalaitteen välistä tiedonsiirtoa varten ja tiedonsiirtolaite
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6217744B1 (en) 1998-12-18 2001-04-17 Peter Crosby Devices for testing fluid
EP1140210B1 (en) 1998-12-21 2003-07-02 Sequella, Inc. Methods and compositions comprising monitoring devices
US6115636A (en) 1998-12-22 2000-09-05 Medtronic, Inc. Telemetry for implantable devices using the body as an antenna
US6269058B1 (en) 1999-01-04 2001-07-31 Texas Instruments Incorporated Wide capture range circuitry
US6358202B1 (en) 1999-01-25 2002-03-19 Sun Microsystems, Inc. Network for implanted computer devices
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6285897B1 (en) 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
US6200265B1 (en) 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6290646B1 (en) 1999-04-16 2001-09-18 Cardiocom Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients
US6755783B2 (en) 1999-04-16 2004-06-29 Cardiocom Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients
ATE256421T1 (de) 1999-05-25 2004-01-15 Medicotest As Hautelektrode
EP1246414B1 (en) 1999-05-26 2012-05-23 Johnson Controls Technology Company Wireless communications system and method therefor
US6366206B1 (en) 1999-06-02 2002-04-02 Ball Semiconductor, Inc. Method and apparatus for attaching tags to medical and non-medical devices
EP1060704A3 (en) 1999-06-18 2002-09-18 Agilent Technologies, Inc. (a Delaware corporation) Multi-parameter capability transmitter for wireless telemetry systems
JP3402267B2 (ja) 1999-06-23 2003-05-06 ソニーケミカル株式会社 電子素子の実装方法
DE19929328A1 (de) 1999-06-26 2001-01-04 Daimlerchrysler Aerospace Ag Vorrichtung zur medizinischen Langzeitüberwachung von Personen
US6287252B1 (en) 1999-06-30 2001-09-11 Monitrak Patient monitor
US6307468B1 (en) 1999-07-20 2001-10-23 Avid Identification Systems, Inc. Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator
HN2000000165A (es) 1999-08-05 2001-07-09 Dimensional Foods Corp Productos holograficos comestibles, particularmente farmaceuticos, y metodos y aparatos para producirlos.
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6206702B1 (en) 1999-08-24 2001-03-27 Deborah A. Hayden Methods and devices for treating unilateral neglect
US6526034B1 (en) 1999-09-21 2003-02-25 Tantivy Communications, Inc. Dual mode subscriber unit for short range, high rate and long range, lower rate data communications
US6533733B1 (en) 1999-09-24 2003-03-18 Ut-Battelle, Llc Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring
US6990082B1 (en) 1999-11-08 2006-01-24 Intel Corporation Wireless apparatus having a transceiver equipped to support multiple wireless communication protocols
CA2386673A1 (en) 1999-10-07 2001-04-12 Anthony R. Montgomery Physiological signal monitoring apparatus and method
US6852084B1 (en) 2000-04-28 2005-02-08 Peter V. Boesen Wireless physiological pressure sensor and transmitter with capability of short range radio frequency transmissions
US6426863B1 (en) 1999-11-25 2002-07-30 Lithium Power Technologies, Inc. Electrochemical capacitor
US6612984B1 (en) 1999-12-03 2003-09-02 Kerr, Ii Robert A. System and method for collecting and transmitting medical data
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US6294999B1 (en) 1999-12-29 2001-09-25 Becton, Dickinson And Company Systems and methods for monitoring patient compliance with medication regimens
US8002700B2 (en) 1999-12-30 2011-08-23 Medtronic, Inc. Communications system for an implantable medical device and a delivery device
EP1119137B1 (en) 2000-01-20 2006-08-16 Lucent Technologies Inc. Interoperability for bluetooth/IEEE 802.11
AR026148A1 (es) 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
US7039453B2 (en) 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
KR100800040B1 (ko) 2000-03-08 2008-01-31 기븐 이미징 리미티드 체내 촬상용 캡슐
US6526315B1 (en) 2000-03-17 2003-02-25 Tanita Corporation Portable bioelectrical impedance measuring instrument
DE10014588A1 (de) 2000-03-27 2001-10-04 Basf Ag Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
US6757523B2 (en) 2000-03-31 2004-06-29 Zeus Wireless, Inc. Configuration of transmit/receive switching in a transceiver
US6622050B2 (en) 2000-03-31 2003-09-16 Medtronic, Inc. Variable encryption scheme for data transfer between medical devices and related data management systems
US6922592B2 (en) 2000-04-04 2005-07-26 Medtronic, Inc. Implantable medical device controlled by a non-invasive physiological data measurement device
US6654638B1 (en) 2000-04-06 2003-11-25 Cardiac Pacemakers, Inc. Ultrasonically activated electrodes
US6496705B1 (en) 2000-04-18 2002-12-17 Motorola Inc. Programmable wireless electrode system for medical monitoring
US6441747B1 (en) 2000-04-18 2002-08-27 Motorola, Inc. Wireless system protocol for telemetry monitoring
US6836862B1 (en) 2000-04-24 2004-12-28 3Com Corporation Method of indicating wireless connection integrity
US6792247B2 (en) 2000-05-08 2004-09-14 Microtune (San Diego), Inc. Co-located frequency-agile system and method
US6432292B1 (en) 2000-05-16 2002-08-13 Metallic Power, Inc. Method of electrodepositing metal on electrically conducting particles
US6988989B2 (en) 2000-05-19 2006-01-24 Welch Allyn Protocol, Inc. Patient monitoring system
US6680923B1 (en) 2000-05-23 2004-01-20 Calypso Wireless, Inc. Communication system and method
DE60106601D1 (de) 2000-05-29 2004-11-25 Medicotest As Olstykke Elektrode zur herstellung eines elektrischen kontakts mit der haut
IL163684A0 (en) 2000-05-31 2005-12-18 Given Imaging Ltd Measurement of electrical characteristics of tissue
US20060122474A1 (en) 2000-06-16 2006-06-08 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
US7261690B2 (en) 2000-06-16 2007-08-28 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
GB0014855D0 (en) 2000-06-16 2000-08-09 Isis Innovation Combining measurements from different sensors
GB0014854D0 (en) 2000-06-16 2000-08-09 Isis Innovation System and method for acquiring data
US6605038B1 (en) 2000-06-16 2003-08-12 Bodymedia, Inc. System for monitoring health, wellness and fitness
US7009946B1 (en) 2000-06-22 2006-03-07 Intel Corporation Method and apparatus for multi-access wireless communication
GB0016561D0 (en) 2000-07-05 2000-08-23 Rolls Royce Plc Health monitoring
US7146228B2 (en) 2000-07-19 2006-12-05 Medicotest A/S Skin electrode with a by-pass element
AU2001277163A1 (en) 2000-07-24 2002-02-05 Motorola, Inc. Ingestible electronic capsule
US6564079B1 (en) 2000-07-27 2003-05-13 Ckm Diagnostics, Inc. Electrode array and skin attachment system for noninvasive nerve location and imaging device
JP4428835B2 (ja) 2000-08-09 2010-03-10 昭和電工株式会社 磁気記録媒体及びその製造方法
US20020026111A1 (en) 2000-08-28 2002-02-28 Neil Ackerman Methods of monitoring glucose levels in a subject and uses thereof
US7685005B2 (en) 2000-08-29 2010-03-23 Medtronic, Inc. Medical device systems implemented network scheme for remote patient management
DE60102331T2 (de) 2000-09-08 2005-03-17 Matsushita Electric Works, Ltd., Kadoma Datenübertragungssystem unter Verwendung eines menschlichen Körpers als Signalübertragungsweg
US6720923B1 (en) 2000-09-14 2004-04-13 Stata Labs, Llc Antenna design utilizing a cavity architecture for global positioning system (GPS) applications
US6572636B1 (en) 2000-09-19 2003-06-03 Robert Sean Hagen Pulse sensing patch and associated methods
AU2001292946A1 (en) 2000-09-26 2002-04-08 Advantage 3D Llc Method and system for generation, storage and distribution of omni-directional object views
AU2002224453A1 (en) 2000-10-11 2002-04-22 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
US7024248B2 (en) 2000-10-16 2006-04-04 Remon Medical Technologies Ltd Systems and methods for communicating with implantable devices
US6738671B2 (en) 2000-10-26 2004-05-18 Medtronic, Inc. Externally worn transceiver for use with an implantable medical device
US6632175B1 (en) 2000-11-08 2003-10-14 Hewlett-Packard Development Company, L.P. Swallowable data recorder capsule medical device
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6689117B2 (en) 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
US6879810B2 (en) 2000-12-20 2005-04-12 Nokia Corporation Control of short range RF communication
JP2002263185A (ja) 2001-03-12 2002-09-17 Sanyo Electric Co Ltd 投薬システム及び方法及び投薬装置
US6342774B1 (en) 2001-03-27 2002-01-29 Motorola, Inc. Battery having user charge capacity control
JP2002290212A (ja) 2001-03-27 2002-10-04 Nec Corp 電圧制御発振器
JP2005500869A (ja) 2001-03-28 2005-01-13 テレバイタル・インコーポレイテッド 広域ネットワークによる生理学的データの実時間モニタリング、判断、解析、検索および記憶を行うためのシステムおよび方法
US6595929B2 (en) 2001-03-30 2003-07-22 Bodymedia, Inc. System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow
WO2002078539A1 (en) 2001-04-02 2002-10-10 N.I. Medical Ltd. Device for determining hemodynamic state
US7407484B2 (en) 2001-04-06 2008-08-05 Medic4All Inc. Physiological monitoring system for a computational device of a human subject
US6694161B2 (en) 2001-04-20 2004-02-17 Monsanto Technology Llc Apparatus and method for monitoring rumen pH
US6801137B2 (en) 2001-04-23 2004-10-05 Cardionet, Inc. Bidirectional communication between a sensor unit and a monitor unit in patient monitoring
US6782290B2 (en) 2001-04-27 2004-08-24 Medtronic, Inc. Implantable medical device with rechargeable thin-film microbattery power source
EP1385575A1 (en) 2001-04-30 2004-02-04 Medtronic, Inc. Transcutaneous monitor and method of use, using therapeutic output from an implanted medical device
KR20030092120A (ko) 2001-05-03 2003-12-03 텔쥬트 테크놀로지스, 인크. 무선 의료용 모니터링 장치 및 시스템
US7039033B2 (en) 2001-05-07 2006-05-02 Ixi Mobile (Israel) Ltd. System, device and computer readable medium for providing a managed wireless network using short-range radio signals
WO2002095351A2 (en) 2001-05-20 2002-11-28 Given Imaging Ltd. A floatable in vivo sensing device
GB0113212D0 (en) 2001-05-31 2001-07-25 Oxford Biosignals Ltd Patient condition display
US20020192159A1 (en) 2001-06-01 2002-12-19 Reitberg Donald P. Single-patient drug trials used with accumulated database: flowchart
KR20040030681A (ko) 2001-06-19 2004-04-09 디지털 스포츠 미디어 생리 감시 시스템
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
US7044911B2 (en) 2001-06-29 2006-05-16 Philometron, Inc. Gateway platform for biological monitoring and delivery of therapeutic compounds
EP2323056A1 (en) 2001-07-11 2011-05-18 CNS Response, Inc. Database and method for creating a database for classifying and treating physiologic brain imbalances using quantitative eeg
WO2003005877A2 (en) 2001-07-12 2003-01-23 Given Imaging Ltd. Device and method for examining a body lumen
US20030017826A1 (en) 2001-07-17 2003-01-23 Dan Fishman Short-range wireless architecture
US7368191B2 (en) 2001-07-25 2008-05-06 Biosource, Inc. Electrode array for use in electrochemical cells
US6951536B2 (en) 2001-07-30 2005-10-04 Olympus Corporation Capsule-type medical device and medical system
US6747556B2 (en) 2001-07-31 2004-06-08 Medtronic Physio-Control Corp. Method and system for locating a portable medical device
US20030065536A1 (en) 2001-08-13 2003-04-03 Hansen Henrik Egesborg Portable device and method of communicating medical data information
WO2003015890A1 (en) 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
JP3962250B2 (ja) 2001-08-29 2007-08-22 株式会社レアメタル 生体内情報検出システム及びこれに用いるタグ装置、中継装置
US6650191B2 (en) 2001-09-07 2003-11-18 Texas Instruments Incorporated Low jitter ring oscillator architecture
US20050137480A1 (en) 2001-10-01 2005-06-23 Eckhard Alt Remote control of implantable device through medical implant communication service band
US6840904B2 (en) 2001-10-11 2005-01-11 Jason Goldberg Medical monitoring device and system
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US6745082B2 (en) 2001-10-22 2004-06-01 Jens Axelgaard Current-controlling electrode with adjustable contact area
US20030152622A1 (en) 2001-10-25 2003-08-14 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral diuretic
US20030083559A1 (en) 2001-10-31 2003-05-01 Thompson David L. Non-contact monitor
US6643541B2 (en) 2001-12-07 2003-11-04 Motorola, Inc Wireless electromyography sensor and system
US20030107487A1 (en) 2001-12-10 2003-06-12 Ronen Korman Method and device for measuring physiological parameters at the wrist
GB0130010D0 (en) 2001-12-14 2002-02-06 Isis Innovation Combining measurements from breathing rate sensors
US7016648B2 (en) 2001-12-18 2006-03-21 Ixi Mobile (Israel) Ltd. Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network
US7729776B2 (en) 2001-12-19 2010-06-01 Cardiac Pacemakers, Inc. Implantable medical device with two or more telemetry systems
US7877273B2 (en) 2002-01-08 2011-01-25 Fredric David Abramson System and method for evaluating and providing nutrigenomic data, information and advice
AU2003205153A1 (en) 2002-01-11 2003-07-30 Hexalog Sa Systems and methods for medication monitoring
US7519416B2 (en) 2002-02-04 2009-04-14 Heartview, Llc Diagnostic method utilizing standard lead ECG signals
FR2835730B1 (fr) * 2002-02-11 2004-12-10 C T M Ct De Transfert Des Micr Dispositif pour la delivrance de substances et le prelevement intracorporel
IL154391A (en) 2002-02-11 2009-05-04 Given Imaging Ltd Self-propelled device
US6935560B2 (en) 2002-02-26 2005-08-30 Safety Syringes, Inc. Systems and methods for tracking pharmaceuticals within a facility
US20030162556A1 (en) 2002-02-28 2003-08-28 Libes Michael A. Method and system for communication between two wireless-enabled devices
US7043305B2 (en) 2002-03-06 2006-05-09 Cardiac Pacemakers, Inc. Method and apparatus for establishing context among events and optimizing implanted medical device performance
US6957107B2 (en) 2002-03-13 2005-10-18 Cardionet, Inc. Method and apparatus for monitoring and communicating with an implanted medical device
US6968153B1 (en) 2002-03-13 2005-11-22 Nokia Corporation Apparatus, method and system for a Bluetooth repeater
US7188767B2 (en) 2002-03-18 2007-03-13 Precision Dynamics Corporation Physical condition or environmental threat detection appliance system
US6850788B2 (en) 2002-03-25 2005-02-01 Masimo Corporation Physiological measurement communications adapter
JP3869291B2 (ja) 2002-03-25 2007-01-17 オリンパス株式会社 カプセル型医療装置
US7376435B2 (en) 2002-04-01 2008-05-20 Intel Corporation Transferring multiple data units over a wireless communication link
US7797033B2 (en) * 2002-04-08 2010-09-14 Smart Pill Corporation Method of using, and determining location of, an ingestible capsule
KR101090667B1 (ko) 2002-04-22 2011-12-07 마시오 마크 아우렐리오 마틴스 애브리우 생물학적 파라미터 측정 장치 및 방법
US7424268B2 (en) 2002-04-22 2008-09-09 Cisco Technology, Inc. System and method for management of a shared frequency band
EP1356762A1 (de) 2002-04-22 2003-10-29 UbiCom Gesellschaft für Telekommunikation mbH Geräteanordnung zur Fernüberwachung von Körperfunktionen
US6960617B2 (en) 2002-04-22 2005-11-01 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
US20030216622A1 (en) 2002-04-25 2003-11-20 Gavriel Meron Device and method for orienting a device in vivo
US7368190B2 (en) 2002-05-02 2008-05-06 Abbott Diabetes Care Inc. Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2003325439A (ja) 2002-05-15 2003-11-18 Olympus Optical Co Ltd カプセル型医療装置
WO2003099102A2 (en) 2002-05-20 2003-12-04 Kevin Marchitto Device and method for wound healing and uses therefor
US6847844B2 (en) 2002-06-06 2005-01-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of data communication with implanted device and associated apparatus
US8003179B2 (en) 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
US20040008123A1 (en) 2002-07-15 2004-01-15 Battelle Memorial Institute System and method for tracking medical devices
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US6909878B2 (en) 2002-08-20 2005-06-21 Ixi Mobile (Israel) Ltd. Method, system and computer readable medium for providing an output signal having a theme to a device in a short distance wireless network
US7020508B2 (en) 2002-08-22 2006-03-28 Bodymedia, Inc. Apparatus for detecting human physiological and contextual information
US7294105B1 (en) 2002-09-03 2007-11-13 Cheetah Omni, Llc System and method for a wireless medical communication system
US20040049245A1 (en) 2002-09-09 2004-03-11 Volker Gass Autonomous patch for communication with an implantable device, and medical kit for using said patch
US7102508B2 (en) 2002-09-09 2006-09-05 Persephone, Inc. Method and apparatus for locating and tracking persons
US7388903B2 (en) 2002-09-18 2008-06-17 Conexant, Inc. Adaptive transmission rate and fragmentation threshold mechanism for local area networks
GB2393356B (en) 2002-09-18 2006-02-01 E San Ltd Telemedicine system
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
US7736309B2 (en) 2002-09-27 2010-06-15 Medtronic Minimed, Inc. Implantable sensor method and system
US6842636B2 (en) 2002-09-27 2005-01-11 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7209790B2 (en) 2002-09-30 2007-04-24 Medtronic, Inc. Multi-mode programmer for medical device communication
US7686762B1 (en) 2002-10-03 2010-03-30 Integrated Sensing Systems, Inc. Wireless device and system for monitoring physiologic parameters
US20040073454A1 (en) 2002-10-10 2004-04-15 John Urquhart System and method of portal-mediated, website-based analysis of medication dosing
US6959217B2 (en) 2002-10-24 2005-10-25 Alfred E. Mann Foundation For Scientific Research Multi-mode crystal oscillator system selectively configurable to minimize power consumption or noise generation
US7027871B2 (en) 2002-10-31 2006-04-11 Medtronic, Inc. Aggregation of data from external data sources within an implantable medical device
US20030126593A1 (en) 2002-11-04 2003-07-03 Mault James R. Interactive physiological monitoring system
EP1437784B1 (en) 2002-11-08 2012-05-30 Honda Motor Co., Ltd. Electrode for solid polymer fuel cell
US20040092801A1 (en) 2002-11-13 2004-05-13 Budimir Drakulic System for, and method of, acquiring physiological signals of a patient
WO2004049947A2 (en) 2002-11-29 2004-06-17 Given Imaging Ltd. Methods device and system for in vivo diagnosis
NZ539915A (en) 2002-12-11 2007-09-28 Pfizer Prod Inc Controlled-release of an active substance into a high fat environment
US20040167226A1 (en) 2002-12-16 2004-08-26 Serafini Tito A. Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
JP2006509574A (ja) 2002-12-16 2006-03-23 ギブン イメージング リミテッド 生体内センサの選択的作動のための装置、システム、及び方法
US7009511B2 (en) 2002-12-17 2006-03-07 Cardiac Pacemakers, Inc. Repeater device for communications with an implantable medical device
EP1590039A1 (en) 2002-12-19 2005-11-02 Koninklijke Philips Electronics N.V. An electrode assembly and a system with impedance control
US7127300B2 (en) 2002-12-23 2006-10-24 Cardiac Pacemakers, Inc. Method and apparatus for enabling data communication between an implantable medical device and a patient management system
US6975174B1 (en) 2002-12-31 2005-12-13 Radioframe Networks, Inc. Clock oscillator
US7396330B2 (en) 2003-01-07 2008-07-08 Triage Data Networks Wireless, internet-based medical-diagnostic system
US20060142648A1 (en) 2003-01-07 2006-06-29 Triage Data Networks Wireless, internet-based, medical diagnostic system
US7512448B2 (en) 2003-01-10 2009-03-31 Phonak Ag Electrode placement for wireless intrabody communication between components of a hearing system
KR100522132B1 (ko) 2003-01-25 2005-10-18 한국과학기술연구원 인체통신시스템에서의 데이터 수신방법 및 수신장치
KR100873683B1 (ko) 2003-01-25 2008-12-12 한국과학기술연구원 인체통신방법, 인체통신시스템 및 이에 사용되는 캡슐형 내시경
JP2006517827A (ja) 2003-01-29 2006-08-03 イー−ピル・ファーマ・リミテッド 胃腸管内における活性薬物の送達
US7002476B2 (en) 2003-01-30 2006-02-21 Leap Of Faith Technologies, Inc. Medication compliance system
EP1443780B1 (en) 2003-01-30 2013-05-29 Accenture Global Services Limited Event data acquisition and transmission system
US7149581B2 (en) 2003-01-31 2006-12-12 Medtronic, Inc. Patient monitoring device with multi-antenna receiver
US7392015B1 (en) 2003-02-14 2008-06-24 Calamp Corp. Calibration methods and structures in wireless communications systems
US7215660B2 (en) 2003-02-14 2007-05-08 Rearden Llc Single transceiver architecture for a wireless network
US7653031B2 (en) 2003-03-05 2010-01-26 Timothy Gordon Godfrey Advance notification of transmit opportunities on a shared-communications channel
US7155232B2 (en) 2003-03-05 2006-12-26 Conexant Systems, Inc. Transmit request signaling between transceivers
EP1606758B1 (en) 2003-03-21 2015-11-18 Welch Allyn, Inc. Personal status physiologic monitor system
US7321920B2 (en) 2003-03-21 2008-01-22 Vocel, Inc. Interactive messaging system
GB0306642D0 (en) * 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
US20040193446A1 (en) 2003-03-27 2004-09-30 Mayer Steven Lloyd System and method for managing a patient treatment program including a prescribed drug regimen
GB0308114D0 (en) 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
JP4593083B2 (ja) 2003-04-11 2010-12-08 オリンパス株式会社 検査データ管理方法
GB0308467D0 (en) 2003-04-11 2003-05-21 Rolls Royce Plc Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components
FI116117B (fi) 2003-04-17 2005-09-30 Polar Electro Oy Mittalaite ja menetelmä sykkeen mittaamiseksi sekä mittalaitteen valmistusmenetelmä
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
KR100741217B1 (ko) 2003-04-25 2007-07-19 올림푸스 가부시키가이샤 무선형 피검체 내 정보 취득 시스템 및 피검체 외부 장치
US20040218683A1 (en) 2003-05-01 2004-11-04 Texas Instruments Incorporated Multi-mode wireless devices having reduced-mode receivers
US20040225199A1 (en) 2003-05-08 2004-11-11 Evanyk Shane Walter Advanced physiological monitoring systems and methods
TWI226761B (en) 2003-05-08 2005-01-11 Ind Tech Res Inst Dual band transceiver architecture for wireless application
US7031745B2 (en) 2003-05-12 2006-04-18 Shen Ein-Yiao Cellular phone combined physiological condition examination and processing device
WO2004100776A1 (ja) 2003-05-14 2004-11-25 Olympus Corporation カプセル型医療装置
KR100542101B1 (ko) 2003-06-02 2006-01-11 삼성전자주식회사 전송 파워 제어 방법 및 이를 이용한 블루투스 장치
US7313163B2 (en) 2003-06-17 2007-12-25 Motorola, Inc. Fast synchronization for half duplex digital communications
US20040260154A1 (en) 2003-06-18 2004-12-23 Boris Sidelnik Human physiological and chemical monitoring system
EP1637063B1 (en) 2003-06-24 2012-11-28 Olympus Corporation Capsule type medical device communication system
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
KR20060039900A (ko) 2003-07-16 2006-05-09 코닌클리케 필립스 일렉트로닉스 엔.브이. 휴대용 전자 디바이스 및 개인의 생리적인 조건을모니터하기 위해 배열된 건강 관리 시스템
US7554452B2 (en) 2003-07-18 2009-06-30 Cary Cole Ingestible tracking and locating device
US7653350B2 (en) 2003-07-24 2010-01-26 Sony Ericsson Mobile Communications Ab Wireless terminals and methods for communicating over cellular and enhanced mode bluetooth communication links
JP4038575B2 (ja) 2003-07-25 2008-01-30 独立行政法人産業技術総合研究所 バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法
US7243118B2 (en) 2003-07-30 2007-07-10 Broadcom Corporation Method and apparatus for efficient derivation of modulo arithmetic for frequency selection
WO2005016558A2 (en) 2003-08-04 2005-02-24 Microchips, Inc. Methods for accelerated release of material from a reservoir device
EP2008581B1 (en) 2003-08-18 2011-08-17 Cardiac Pacemakers, Inc. Patient monitoring, diagnosis, and/or therapy systems and methods
EP2382920A1 (en) 2003-08-20 2011-11-02 Philometron, Inc. Hydration monitoring
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
JP4398204B2 (ja) 2003-08-29 2010-01-13 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
WO2005024687A1 (ja) 2003-09-02 2005-03-17 Fujitsu Limited 薬服用状況管理方法、薬剤及び薬服用状況管理装置
US20050062644A1 (en) 2003-09-08 2005-03-24 Leci Jonathan Ilan Capsule device to identify the location of an individual
JP3993546B2 (ja) 2003-09-08 2007-10-17 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
JP4603547B2 (ja) 2003-09-11 2010-12-22 セラノス， インコーポレイテッド 検体の監視および薬物送達のための医療デバイス
US7813809B2 (en) 2004-06-10 2010-10-12 Medtronic, Inc. Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue
US7352998B2 (en) 2003-09-12 2008-04-01 Nokia Corporation Method and system for establishing a wireless communications link
US7499674B2 (en) 2003-09-12 2009-03-03 Nokia Corporation Method and system for repeat request in hybrid ultra wideband-bluetooth radio
JP4153852B2 (ja) 2003-09-18 2008-09-24 オリンパス株式会社 エネルギー供給用コイルおよびこれを用いた無線型被検体内情報取得システム
US20090157358A1 (en) 2003-09-22 2009-06-18 Hyeung-Yun Kim System for diagnosing and monitoring structural health conditions
EP1685456A2 (en) 2003-09-22 2006-08-02 Kim Hyeung-Yun Sensors and systems for structural health monitoring
US7218967B2 (en) 2003-09-26 2007-05-15 Medtronic, Inc. System and method for real-time remote monitoring of implantable medical devices
JP4503979B2 (ja) * 2003-10-22 2010-07-14 オリンパス株式会社 体内装置および医療機器
US20050096514A1 (en) 2003-11-01 2005-05-05 Medtronic, Inc. Gastric activity notification
US6892590B1 (en) 2003-11-04 2005-05-17 Andermotion Technologies Llc Single-balanced shield electrode configuration for use in capacitive displacement sensing systems and methods
US7101343B2 (en) 2003-11-05 2006-09-05 Temple University Of The Commonwealth System Of Higher Education Implantable telemetric monitoring system, apparatus, and method
US20050101843A1 (en) 2003-11-06 2005-05-12 Welch Allyn, Inc. Wireless disposable physiological sensor
US7415242B1 (en) 2003-11-10 2008-08-19 Sprint Spectrum L.P. Method and system for proximity detection for an in-building wireless repeater
DE102004032812B4 (de) 2003-11-11 2006-07-20 Dräger Safety AG & Co. KGaA Kombinationssensor für physiologische Messgrößen
JP2005158770A (ja) 2003-11-20 2005-06-16 Matsushita Electric Ind Co Ltd 積層基板とその製造方法及び前記積層基板を用いたモジュールの製造方法とその製造装置
US6987691B2 (en) 2003-12-02 2006-01-17 International Business Machines Corporation Easy axis magnetic amplifier
US7427266B2 (en) 2003-12-15 2008-09-23 Hewlett-Packard Development Company, L.P. Method and apparatus for verification of ingestion
US8306592B2 (en) 2003-12-19 2012-11-06 Olympus Corporation Capsule medical device
JP4198045B2 (ja) 2003-12-25 2008-12-17 オリンパス株式会社 被検体内位置検出システム
JP2005185567A (ja) 2003-12-25 2005-07-14 Olympus Corp 医療用カプセル装置
US7392091B2 (en) 2003-12-30 2008-06-24 Cochlear Limited Implanted antenna and radio communications link
JP2005192821A (ja) 2004-01-07 2005-07-21 Olympus Corp カプセル型医療装置
JP2005193535A (ja) 2004-01-07 2005-07-21 Alps Electric Co Ltd サーマルヘッド及びその製造方法、並びにサーマルヘッドのドットアスペクト比調整方法
US7176784B2 (en) 2004-01-21 2007-02-13 Battelle Memorial Institute K1-53 Multi-mode radio frequency device
US7342895B2 (en) 2004-01-30 2008-03-11 Mark Serpa Method and system for peer-to-peer wireless communication over unlicensed communication spectrum
US7647112B2 (en) 2004-02-11 2010-01-12 Ethicon, Inc. System and method for selectively stimulating different body parts
US20050187789A1 (en) 2004-02-25 2005-08-25 Cardiac Pacemakers, Inc. Advanced patient and medication therapy management system and method
US7904133B2 (en) 2004-02-27 2011-03-08 Koninklijke Philips Electronics N.V. Wearable wireless device for monitoring, analyzing and communicating physiological status
CN1284505C (zh) 2004-02-28 2006-11-15 重庆金山科技（集团）有限公司 医用无线电胶囊式内窥系统
US7406105B2 (en) 2004-03-03 2008-07-29 Alfred E. Mann Foundation For Scientific Research System and method for sharing a common communication channel between multiple systems of implantable medical devices
WO2005084521A1 (ja) 2004-03-04 2005-09-15 Olympus Corporation カプセル型医療システム
GB0405798D0 (en) 2004-03-15 2004-04-21 E San Ltd Medical data display
JP4520198B2 (ja) 2004-04-07 2010-08-04 オリンパス株式会社 被検体内位置表示システム
US20050234307A1 (en) 2004-04-15 2005-10-20 Nokia Corporation Physiological event handling system and method
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US9801527B2 (en) 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
JP2005304880A (ja) 2004-04-23 2005-11-04 Hitachi Ltd 非接触ｉｃタグを利用した体内物体管理システム
US8019471B2 (en) 2004-04-24 2011-09-13 Inrange Systems, Inc. Integrated, non-sequential, remote medication management and compliance system
US20050245794A1 (en) 2004-04-29 2005-11-03 Medtronic, Inc. Communication with implantable monitoring probe
GB0410248D0 (en) 2004-05-07 2004-06-09 Isis Innovation Signal analysis method
EP1750585A1 (en) 2004-05-16 2007-02-14 Medic4all AG Method and device for measuring physiological parameters at the hand
US20050261559A1 (en) 2004-05-18 2005-11-24 Mumford John R Wireless physiological monitoring system
US7575005B2 (en) 2004-05-18 2009-08-18 Excel-Tech Ltd. Mask assembly with integrated sensors
US7125382B2 (en) 2004-05-20 2006-10-24 Digital Angel Corporation Embedded bio-sensor system
US20050259768A1 (en) 2004-05-21 2005-11-24 Oki Techno Centre (Singapore) Pte Ltd Digital receiver and method for processing received signals
KR100592934B1 (ko) 2004-05-21 2006-06-23 한국전자통신연구원 착용형 생체신호 검출모듈 및 이를 포함한 측정장치
US7653542B2 (en) 2004-05-26 2010-01-26 Verizon Business Global Llc Method and system for providing synthesized speech
CA2567688C (en) 2004-05-28 2016-08-02 Jan De Geest Communication unit for a person's skin
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
US7289855B2 (en) 2004-06-09 2007-10-30 Medtronic, Inc. Implantable medical device package antenna
US7697994B2 (en) 2004-06-18 2010-04-13 Medtronic, Inc. Remote scheduling for management of an implantable medical device
KR100615431B1 (ko) 2004-06-22 2006-08-25 한국전자통신연구원 생체신호 검출모듈, 다채널 커넥터 모듈 및 이를 포함한생체신호 검출장치
JP2006006377A (ja) 2004-06-22 2006-01-12 Elquest Corp 薬剤包装用の薬包紙
US20050285746A1 (en) 2004-06-25 2005-12-29 Sengupta Uttam K Radio frequency identification based system to track consumption of medication
US7206630B1 (en) 2004-06-29 2007-04-17 Cleveland Medical Devices, Inc Electrode patch and wireless physiological measurement system and method
US20070027383A1 (en) 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
US20060001496A1 (en) 2004-07-02 2006-01-05 Abrosimov Igor A Array oscillator and polyphase clock generator
JP4462614B2 (ja) 2004-07-05 2010-05-12 ソニー・エリクソン・モバイルコミュニケーションズ株式会社 近距離無線通信システム、携帯端末装置および無線通信装置
US7343186B2 (en) 2004-07-07 2008-03-11 Masimo Laboratories, Inc. Multi-wavelength physiological monitor
WO2006006158A1 (en) 2004-07-09 2006-01-19 Aerotel Medical Systems (1998) Ltd. Wearable device, system and method for measuring vital parameters
US20080027679A1 (en) 2004-07-21 2008-01-31 Dror Shklarski Wearable Device, System and Method for Measuring Physiological and/or Environmental Parameters
CN100459614C (zh) 2004-07-22 2009-02-04 华为技术有限公司 一种手机外设装置与方法
US20080045843A1 (en) 2004-08-12 2008-02-21 Tomoharu Tsuji Via-Human-Body Information Transmission System and Transmitter-Receiver
US7253716B2 (en) 2004-08-17 2007-08-07 Tagent Corporation Trackable pills with electronic ID tags
US7317378B2 (en) 2004-08-17 2008-01-08 Tagent Corporation Product identification tag device and reader
US20060058602A1 (en) 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
CN101010114B (zh) 2004-08-27 2010-05-26 皇家飞利浦电子股份有限公司 电子遥控药丸和用于供应至少一种药物的系统
EP1794585A1 (en) 2004-08-31 2007-06-13 Lifescan Scotland Ltd Method of manufacturing an auto-calibrating sensor
KR100727817B1 (ko) 2004-09-07 2007-06-13 한국전자통신연구원 인체를 매질로 이용한 통신장치 및 그 방법
CA2578078A1 (en) 2004-09-08 2006-03-16 Alertis Medical As Sensor
KR20060023228A (ko) 2004-09-09 2006-03-14 이기방 다공질물질을 가지는 배터리와 배터리제조방법
GB2418144A (en) 2004-09-17 2006-03-22 Psimedica Ltd Medical device for delivery of beneficial substance
US20060065713A1 (en) 2004-09-24 2006-03-30 John Russell Kingery System and method for monitored administration of medical products to patients
US7618374B2 (en) 2004-09-27 2009-11-17 Siemens Medical Solutions Usa, Inc. Image plane sensing methods and systems for intra-patient probes
US7341560B2 (en) 2004-10-05 2008-03-11 Rader, Fishman & Grauer Pllc Apparatuses and methods for non-invasively monitoring blood parameters
US20060078765A1 (en) 2004-10-12 2006-04-13 Laixia Yang Nano-structured ion-conducting inorganic membranes for fuel cell applications
EP1827217B1 (en) 2004-11-02 2010-08-11 Medtronic, Inc. Techniques for data reporting in an implantable medical device
US7917199B2 (en) 2004-11-02 2011-03-29 Medtronic, Inc. Patient event marking in combination with physiological signals
AU2005229684A1 (en) 2004-11-04 2006-05-18 Given Imaging Ltd Apparatus and method for receiving device selection and combining
KR20060040500A (ko) 2004-11-06 2006-05-10 삼성전자주식회사 생체신호 측정 장치 및 방법
US7414534B1 (en) 2004-11-09 2008-08-19 Pacesetter, Inc. Method and apparatus for monitoring ingestion of medications using an implantable medical device
US7214107B2 (en) 2004-11-22 2007-05-08 Cardiodynamics International Corporation Electrical connector apparatus and methods
US8374693B2 (en) 2004-12-03 2013-02-12 Cardiac Pacemakers, Inc. Systems and methods for timing-based communication between implantable medical devices
US7154071B2 (en) 2004-12-07 2006-12-26 Dräger Safety AG & Co. KGaA Device for transmitting an electric signal detected by contact with the skin surface
ATE545361T1 (de) 2004-12-13 2012-03-15 Koninkl Philips Electronics Nv Mobile überwachung
WO2006064502A2 (en) 2004-12-14 2006-06-22 E-Pill Pharma, Ltd. Local delivery of drugs or substances using electronic permeability increase
US20060136266A1 (en) 2004-12-20 2006-06-22 E-San Limited Medicinal product order processing system
US7249212B2 (en) 2004-12-22 2007-07-24 International Business Machines Corporation Bluetooth association based on docking connection
US7146449B2 (en) 2004-12-22 2006-12-05 International Business Machines Corporation Bluetooth association with simple power connection
ATE399501T1 (de) 2004-12-30 2008-07-15 Given Imaging Ltd System zur lokalisation einer in-vivo signalquelle
US20060148254A1 (en) 2005-01-05 2006-07-06 Mclean George Y Activated iridium oxide electrodes and methods for their fabrication
CN101107025A (zh) 2005-01-17 2008-01-16 诺和诺德公司 附有生理特征综合监测的流体输送装置
US20080194912A1 (en) 2005-01-18 2008-08-14 Koninklijke Philips Electronics, N.V. Electronically Controlled Ingestible Capsule for Sampling Fluids in Alimentary Tract
EP1841490A2 (en) 2005-01-18 2007-10-10 Koninklijke Philips Electronics N.V. Electronically controlled capsule
CN101237903A (zh) 2005-01-18 2008-08-06 皇家飞利浦电子股份有限公司 用于控制所摄入胶囊通过的系统和方法
WO2006077527A2 (en) 2005-01-18 2006-07-27 Koninklijke Philips Electronics, N.V. Electronically controlled capsule for releasing radiation
US8226610B2 (en) 2005-02-01 2012-07-24 Intelliject, Inc. Medical injector with compliance tracking and monitoring
JP4099484B2 (ja) 2005-02-09 2008-06-11 株式会社カイザーテクノロジー 通信システム。
JP4731936B2 (ja) 2005-02-09 2011-07-27 本田技研工業株式会社 回転式可変抵抗器
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
AU2006212007A1 (en) 2005-02-11 2006-08-17 The University Court Of The University Of Glasgow Sensing device, apparatus and system, and method for operating the same
US7504954B2 (en) 2005-03-17 2009-03-17 Spaeder Jeffrey A Radio frequency identification pharmaceutical tracking system and method
WO2006102412A2 (en) 2005-03-21 2006-09-28 Abbott Diabetes Care, Inc. Method and system for providing integrated medication infusion and analyte monitoring system
US7859401B2 (en) 2005-03-22 2010-12-28 Koninklijke Philips Electronics N.V. Addressing scheme for smart wireless medical sensor networks
US20060216603A1 (en) 2005-03-26 2006-09-28 Enable Ipc Lithium-ion rechargeable battery based on nanostructures
US7848820B2 (en) 2005-04-07 2010-12-07 St. Jude Medical Ab System and method for radio communication between an implantable medical device and an external base unit
US7270633B1 (en) 2005-04-22 2007-09-18 Cardiac Pacemakers, Inc. Ambulatory repeater for use in automated patient care and method thereof
US20120024889A1 (en) * 2005-04-28 2012-02-02 Timothy Robertson Polypharmacy Co-Packaged Medication Dosing Unit Including Communication System Therefor
US7414543B2 (en) 2005-04-28 2008-08-19 Honeywell International Inc. Multiple miniature avionic displays
US9198608B2 (en) * 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
US20060247505A1 (en) 2005-04-28 2006-11-02 Siddiqui Waqaas A Wireless sensor system
US7359674B2 (en) 2005-05-10 2008-04-15 Nokia Corporation Content distribution & communication system for enhancing service distribution in short range radio environment
US7375739B2 (en) 2005-05-17 2008-05-20 Vardex Laser Corporation Image management system operable to manage the formation of dynamically variable images in objects in single shot events
JP4933538B2 (ja) * 2005-05-20 2012-05-16 ダウ グローバル テクノロジーズ エルエルシー 無線周波識別標識を用いた経口薬服薬履行監視
US8285205B2 (en) 2005-05-26 2012-10-09 Broadcom Corporation Method and system for a single chip integrated Bluetooth and FM transceiver and baseband processor
US20060273882A1 (en) 2005-06-01 2006-12-07 Intel Corporation RFID tag with separate transmit and receive clocks and related method
US20060276702A1 (en) 2005-06-03 2006-12-07 Mcginnis William Neurophysiological wireless bio-sensor
US7387607B2 (en) 2005-06-06 2008-06-17 Intel Corporation Wireless medical sensor system
EP1904173B8 (en) 2005-06-09 2016-06-08 Medtronic, Inc. Implantable medical device with electrodes on multiple housing surfaces
US20060282001A1 (en) 2005-06-09 2006-12-14 Michel Noel Physiologic sensor apparatus
WO2006130988A1 (en) 2005-06-10 2006-12-14 Telecommunications Research Laboratories Wireless communication system
ITTO20050407A1 (it) 2005-06-13 2006-12-14 Ist Superiore Mario Boella Sistema di monitoraggio remoto di parametri fisiologici di un individuo, procedimento e prodotto informatico
US7616111B2 (en) 2005-06-20 2009-11-10 Carestream Health, Inc. System to monitor the ingestion of medicines
US7782189B2 (en) 2005-06-20 2010-08-24 Carestream Health, Inc. System to monitor the ingestion of medicines
WO2007002697A2 (en) 2005-06-28 2007-01-04 Mayo Foundation For Medical Education And Research System for monitoring a physical parameter of a subject
FI20055366A0 (fi) 2005-06-30 2005-06-30 Gen Electric Elektrodi biopotentiaalisignaalin saamiseksi
US20070016089A1 (en) 2005-07-15 2007-01-18 Fischell David R Implantable device for vital signs monitoring
CA2616010C (en) 2005-07-20 2013-11-05 Neil R. Euliano Medication compliance system and associated methods
CN100471445C (zh) 2005-08-01 2009-03-25 周常安 贴片式生理监测装置
WO2007021813A2 (en) 2005-08-11 2007-02-22 Eksigent Technologies, Llc Microfluidic system and methods
US20090124871A1 (en) 2005-08-22 2009-05-14 Khalil Arshak Tracking system
US8116809B2 (en) 2005-08-29 2012-02-14 Intel Corporation Method and apparatus of multiple entity wireless communication adapter
US8827904B2 (en) 2005-08-31 2014-09-09 Medtronic, Inc. Automatic parameter status on an implantable medical device system
EP1920418A4 (en) 2005-09-01 2010-12-29 Proteus Biomedical Inc IMPLANTABLE WIRELESS COMMUNICATION SYSTEMS
JP2007068622A (ja) 2005-09-05 2007-03-22 Olympus Corp 被検体内情報取得システム
WO2007033379A2 (en) 2005-09-14 2007-03-22 Neoguide Systems, Inc. Methods and apparatus for performing transluminal and other procedures
US20070196456A1 (en) 2005-09-15 2007-08-23 Visible Assets, Inc. Smart patch
US7673679B2 (en) 2005-09-19 2010-03-09 Schlumberger Technology Corporation Protective barriers for small devices
US20080058614A1 (en) 2005-09-20 2008-03-06 Triage Wireless, Inc. Wireless, internet-based system for measuring vital signs from a plurality of patients in a hospital or medical clinic
GB0519837D0 (en) 2005-09-29 2005-11-09 Smartlife Technology Ltd Knitting techniques
GB0519836D0 (en) 2005-09-29 2005-11-09 Smartlife Technology Ltd Contact sensors
US20070078324A1 (en) 2005-09-30 2007-04-05 Textronics, Inc. Physiological Monitoring Wearable Having Three Electrodes
GB0519945D0 (en) 2005-09-30 2005-11-09 Cambridge Silicon Radio Ltd Communication in dual protocol environments
CN100466966C (zh) 2005-10-08 2009-03-11 周常安 呼吸气流生理信号提取和监测装置及系统
US7733224B2 (en) 2006-06-30 2010-06-08 Bao Tran Mesh network personal emergency response appliance
US9154616B2 (en) 2005-10-18 2015-10-06 Oia Intellectuals, Inc. Wearable capture and communication
US7720036B2 (en) 2005-10-26 2010-05-18 Intel Corporation Communication within a wireless network using multiple frequency bands
US7499739B2 (en) 2005-10-27 2009-03-03 Smiths Medical Pm, Inc. Single use pulse oximeter
US8515348B2 (en) 2005-10-28 2013-08-20 Electro Industries/Gauge Tech Bluetooth-enable intelligent electronic device
US9067047B2 (en) * 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
GB0523447D0 (en) 2005-11-17 2005-12-28 E San Ltd System and method for communicating environmentally-based medical support advice
US8016776B2 (en) 2005-12-02 2011-09-13 Medtronic, Inc. Wearable ambulatory data recorder
US8295932B2 (en) 2005-12-05 2012-10-23 Metacure Limited Ingestible capsule for appetite regulation
NL1030608C2 (nl) 2005-12-06 2007-06-07 Patrick Antonius Hendri Meeren Blisterverpakking, samenstel van een blisterverpakking en een houder, alsmede werkwijze voor het verpakken van objecten.
CN1985752A (zh) 2005-12-19 2007-06-27 周常安 分布式生理信号监测设备
US7678043B2 (en) 2005-12-29 2010-03-16 Given Imaging, Ltd. Device, system and method for in-vivo sensing of a body lumen
US20070156016A1 (en) 2005-12-29 2007-07-05 Ido Betesh Method and system for communication with an ingestible imaging device
WO2007073702A2 (es) 2005-12-29 2007-07-05 Osmotica Corp. Comprimido multicapa con combinación de triple liberación
US20070162089A1 (en) 2006-01-09 2007-07-12 Transoma Medical, Inc. Cross-band communications in an implantable device
US8301254B2 (en) 2006-01-09 2012-10-30 Greatbatch Ltd. Cross-band communications in an implantable device
US8078278B2 (en) 2006-01-10 2011-12-13 Remon Medical Technologies Ltd. Body attachable unit in wireless communication with implantable devices
ATE441452T1 (de) 2006-01-23 2009-09-15 Koninkl Philips Electronics Nv Verbesserte biomedizinische elektrode zur längeren anwendung bei patienten mit einem deckel oder schnapper, der von der haltedichtung isoliert ist
US20070185393A1 (en) 2006-02-03 2007-08-09 Triage Wireless, Inc. System for measuring vital signs using an optical module featuring a green light source
US7809399B2 (en) 2006-02-10 2010-10-05 Syntek International Holding Ltd. Method and device for providing multiple communication protocols with a single transceiver
US20090023391A1 (en) 2006-02-24 2009-01-22 Koninklijke Philips Electronics N. V. Wireless body sensor network
US20100049006A1 (en) 2006-02-24 2010-02-25 Surendar Magar Medical signal processing system with distributed wireless sensors
US8200320B2 (en) 2006-03-03 2012-06-12 PhysioWave, Inc. Integrated physiologic monitoring systems and methods
WO2007104152A2 (en) 2006-03-14 2007-09-20 Jamie Hackett Long-range radio frequency receiver-controller module and wireless control system comprising same
US8920343B2 (en) 2006-03-23 2014-12-30 Michael Edward Sabatino Apparatus for acquiring and processing of physiological auditory signals
WO2007109904A1 (en) 2006-03-29 2007-10-04 Electronic Dietary Foods Inc. Ingestible implement for weight control
CN101416194A (zh) * 2006-03-30 2009-04-22 陶氏环球技术公司 用于监控并分析体内用药方案的依从的方法与系统
TW200738212A (en) 2006-04-12 2007-10-16 Guo Terry Bo Jau Miniature wireless apparatus for collecting physiological signals of animals
CA2649447A1 (en) * 2006-04-25 2007-11-08 Dow Global Technologies Inc. Oral drug compliance monitoring using magnetic-field sensors
US7912537B2 (en) 2006-04-27 2011-03-22 Medtronic, Inc. Telemetry-synchronized physiological monitoring and therapy delivery systems
GB0608829D0 (en) 2006-05-04 2006-06-14 Husheer Shamus L G In-situ measurement of physical parameters
WO2007128165A1 (fr) 2006-05-09 2007-11-15 Fangen Xiong Systèmes de réseaux sans fil courte portée et procédé de montage consistant à attribuer des créneaux temporels avec un émetteur-récepteur rf multivoie
US20080051647A1 (en) 2006-05-11 2008-02-28 Changwang Wu Non-invasive acquisition of large nerve action potentials (NAPs) with closely spaced surface electrodes and reduced stimulus artifacts
US7558622B2 (en) 2006-05-24 2009-07-07 Bao Tran Mesh network stroke monitoring appliance
US8384525B2 (en) 2006-05-15 2013-02-26 Nokia Corporation Contactless programming and testing of memory elements
US7539533B2 (en) 2006-05-16 2009-05-26 Bao Tran Mesh network monitoring appliance
US20080119716A1 (en) 2006-05-17 2008-05-22 Olga Boric-Lubecke Determining presence and/or physiological motion of one or more subjects with quadrature doppler radar receiver systems
CN101073494B (zh) 2006-05-18 2010-09-08 周常安 非侵入式生命迹象监测设备、系统及方法
EP3616611B1 (en) 2006-06-01 2020-12-30 ResMed Sensor Technologies Limited Apparatus, system, and method for monitoring physiological signs
US20070279217A1 (en) 2006-06-01 2007-12-06 H-Micro, Inc. Integrated mobile healthcare system for cardiac care
DE502006004740D1 (de) 2006-06-14 2009-10-15 Paul Mueller Gmbh & Co Kg Spindel mit Zugstange und Stromleiter
US7346380B2 (en) 2006-06-16 2008-03-18 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7949404B2 (en) 2006-06-26 2011-05-24 Medtronic, Inc. Communications network for distributed sensing and therapy in biomedical applications
US20080046038A1 (en) 2006-06-26 2008-02-21 Hill Gerard J Local communications network for distributed sensing and therapy in biomedical applications
US20080020037A1 (en) 2006-07-11 2008-01-24 Robertson Timothy L Acoustic Pharma-Informatics System
US7962174B2 (en) 2006-07-12 2011-06-14 Andrew Llc Transceiver architecture and method for wireless base-stations
US20080021521A1 (en) 2006-07-18 2008-01-24 Cardiac Pacemakers, Inc. Implantable Medical Device Communication System
DE102007020583B4 (de) 2006-07-19 2012-10-11 Erbe Elektromedizin Gmbh Elektrodeneinrichtung mit einerImnpedanz-Messeinrichtung und Verfahren zum Herstellen einer derartigen Elektrodeneinrichtung
EP2051615A4 (en) 2006-08-10 2011-03-23 Given Imaging Ltd SYSTEM AND METHOD FOR IN VIVO IMAGING
US20080097549A1 (en) 2006-09-01 2008-04-24 Colbaugh Michael E Electrode Assembly and Method of Using Same
US7756573B2 (en) 2006-09-05 2010-07-13 Cardiac Pacemakers, Inc. Implantable medical device diagnostic data acquisition and storage
US8615284B2 (en) 2006-09-06 2013-12-24 Innurvation, Inc. Method for acoustic information exchange involving an ingestible low power capsule
WO2008030480A2 (en) 2006-09-06 2008-03-13 Innurvation, Inc. Ingestible low power sensor device and system for communicating with same
CN101516256A (zh) 2006-09-18 2009-08-26 皇家飞利浦电子股份有限公司 基于ip的监测和报警
US20080077028A1 (en) 2006-09-27 2008-03-27 Biotronic Crm Patent Personal health monitoring and care system
US20080077184A1 (en) 2006-09-27 2008-03-27 Stephen Denker Intravascular Stimulation System With Wireless Power Supply
US9227011B2 (en) 2006-09-29 2016-01-05 MEDIMETRICS Personalized Drug Delivery B.V. Miniaturized threshold sensor
US20080091114A1 (en) 2006-10-11 2008-04-17 Pacesetter, Inc. Techniques for Correlating Thoracic Impedance with Physiological Status
US20080091089A1 (en) 2006-10-12 2008-04-17 Kenneth Shane Guillory Single use, self-contained surface physiological monitor
US8054140B2 (en) 2006-10-17 2011-11-08 Proteus Biomedical, Inc. Low voltage oscillator for medical devices
US20080097917A1 (en) 2006-10-24 2008-04-24 Kent Dicks Systems and methods for wireless processing and medical device monitoring via remote command execution
JP5916277B2 (ja) 2006-10-25 2016-05-11 プロテウス デジタル ヘルス， インコーポレイテッド 摂取可能な制御活性化識別子
US20080119705A1 (en) 2006-11-17 2008-05-22 Medtronic Minimed, Inc. Systems and Methods for Diabetes Management Using Consumer Electronic Devices
US8718193B2 (en) 2006-11-20 2014-05-06 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
WO2008062333A2 (en) 2006-11-21 2008-05-29 Koninklijke Philips Electronics, N.V. Ingestible electronic capsule and in vivo drug delivery or diagnostic system
GB0624085D0 (en) 2006-12-01 2007-01-10 Oxford Biosignals Ltd Biomedical signal analysis method
GB0624081D0 (en) 2006-12-01 2007-01-10 Oxford Biosignals Ltd Biomedical signal analysis method
US20080137566A1 (en) 2006-12-06 2008-06-12 Bojko Marholev Method and System for Shared High-Power Transmit Path for a Multi-Protocol Transceiver
US20080146889A1 (en) 2006-12-13 2008-06-19 National Yang-Ming University Method of monitoring human physiological parameters and safty conditions universally
US8157730B2 (en) 2006-12-19 2012-04-17 Valencell, Inc. Physiological and environmental monitoring systems and methods
TWI334747B (en) 2006-12-22 2010-12-11 Unimicron Technology Corp Circuit board structure having embedded electronic components
BRPI0720856A2 (pt) 2007-01-10 2014-03-25 Camillo Ricordi Sistema de alerta de emergência móvel
US20080175898A1 (en) 2007-01-16 2008-07-24 Dow Global Technologies, Inc. Oral drug capsule component incorporating a communication device
US20080294020A1 (en) 2007-01-25 2008-11-27 Demetrios Sapounas System and method for physlological data readings, transmission and presentation
US20080183245A1 (en) 2007-01-31 2008-07-31 Van Oort Geeske Telemetry of external physiological sensor data and implantable medical device data to a central processing system
MY165368A (en) 2007-02-01 2018-03-21 Proteus Digital Health Inc Ingestible event marker systems
US20080214985A1 (en) 2007-02-02 2008-09-04 Activatek, Inc. Active transdermal medicament patch
EP3236524A1 (en) 2007-02-14 2017-10-25 Proteus Digital Health, Inc. In-body power source having high surface area electrode
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
WO2008112577A1 (en) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. In-body device having a multi-directional transmitter
US20080303638A1 (en) 2007-03-24 2008-12-11 Hap Nguyen Portable patient devices, systems, and methods for providing patient aid and preventing medical errors, for monitoring patient use of ingestible medications, and for preventing distribution of counterfeit drugs
WO2008120128A2 (en) 2007-03-30 2008-10-09 Koninklijke Philips Electronics N.V. System and method for pill communication and control
KR100895297B1 (ko) 2007-04-30 2009-05-07 한국전자통신연구원 다양한 생체 신호의 동시 측정을 위한 다채널 전극센서장치
US20100256461A1 (en) 2007-05-01 2010-10-07 Urodynamix Technologies Ltd. Apparatus and methods for evaluating physiological conditions of tissue
GB0709248D0 (en) 2007-05-14 2007-06-20 T & Medical Ltd System for monitoring chemotherapy associated adverse drug reactions
US8412293B2 (en) 2007-07-16 2013-04-02 Optiscan Biomedical Corporation Systems and methods for determining physiological parameters using measured analyte values
US8540632B2 (en) * 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
US20080300572A1 (en) 2007-06-01 2008-12-04 Medtronic Minimed, Inc. Wireless monitor for a personal medical device system
US8060175B2 (en) 2007-06-15 2011-11-15 General Electric Company System and apparatus for collecting physiological signals from a plurality of electrodes
US20080311852A1 (en) 2007-06-15 2008-12-18 Broadcom Corporation Multiple communication link coordination for shared data transmissions
GB2450517A (en) 2007-06-27 2008-12-31 Smartlife Technology Ltd Electrical resistance of yarn or fabric changes with temperature
JP5065780B2 (ja) 2007-07-03 2012-11-07 株式会社日立製作所 Ｒｆｉｄタグ実装基板
US20090009332A1 (en) * 2007-07-03 2009-01-08 Endotronix, Inc. System and method for monitoring ingested medication via rf wireless telemetry
JP4520491B2 (ja) 2007-07-09 2010-08-04 オリンパス株式会社 カプセル型医療システム
WO2009010970A2 (en) * 2007-07-16 2009-01-22 Mabat Chemical Systems Ltd. Modular chemical delivery unit
US8340750B2 (en) 2007-07-19 2012-12-25 Medtronic, Inc. Mechanical function marker channel for cardiac monitoring and therapy control
GB0714807D0 (en) 2007-07-30 2007-09-12 Oxford Biosignals Ltd Method and apparatus for measuring breathing rate
KR100863064B1 (ko) 2007-08-03 2008-10-13 한국전자통신연구원 생체 신호 측정용 의복 및 그 제조 방법
KR101080423B1 (ko) 2007-08-03 2011-11-04 삼성전자주식회사 멀티모듈결합형 휴대전자장치
US20090048498A1 (en) 2007-08-17 2009-02-19 Frank Riskey System and method of monitoring an animal
US20090062670A1 (en) 2007-08-30 2009-03-05 Gary James Sterling Heart monitoring body patch and system
US20100222652A1 (en) 2007-09-07 2010-09-02 Ok Kyung Cho Diagnostic sensor unit
US20090069642A1 (en) 2007-09-11 2009-03-12 Aid Networks, Llc Wearable Wireless Electronic Patient Data Communications and Physiological Monitoring Device
WO2009036333A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Dynamic pairing of patients to data collection gateways
US20090076342A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Adherent Multi-Sensor Device with Empathic Monitoring
PT2192946T (pt) 2007-09-25 2022-11-17 Otsuka Pharma Co Ltd Dispositivo no corpo com amplificação de sinal dipolo virtual
US20090087483A1 (en) 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US20090088618A1 (en) 2007-10-01 2009-04-02 Arneson Michael R System and Method for Manufacturing a Swallowable Sensor Device
US20090105561A1 (en) 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US20090105567A1 (en) 2007-10-19 2009-04-23 Smiths Medical Pm, Inc. Wireless telecommunications network adaptable for patient monitoring
US8134459B2 (en) 2007-10-19 2012-03-13 Smiths Medical Asd, Inc. Wireless telecommunications system adaptable for patient monitoring
US8139225B2 (en) 2007-10-24 2012-03-20 Siemens Medical Solutions Usa, Inc. System for processing patient monitoring power and data signals
GB0721117D0 (en) 2007-10-26 2007-12-05 T & Medical Ltd system for assisting in drug dose optimisaion
US20090112626A1 (en) 2007-10-30 2009-04-30 Cary Talbot Remote wireless monitoring, processing, and communication of patient data
WO2009063377A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
EP2215726B1 (en) 2007-11-27 2018-01-10 Proteus Digital Health, Inc. Transbody communication systems employing communication channels
US20090157113A1 (en) 2007-12-18 2009-06-18 Ethicon Endo-Surgery, Inc. Wearable elements for implantable restriction systems
JP5535936B2 (ja) 2007-12-20 2014-07-02 コーニンクレッカ フィリップス エヌ ヴェ 静電容量の検知及び通信
JP5091657B2 (ja) 2007-12-21 2012-12-05 株式会社東芝 無線通信装置及び無線通信方法
US20090171180A1 (en) 2007-12-28 2009-07-02 Trevor Pering Method and apparatus for configuring wearable sensors
WO2009091910A1 (en) 2008-01-15 2009-07-23 Cardiac Pacemakers, Inc. Implantable medical device with wireless communications
WO2009091911A1 (en) 2008-01-15 2009-07-23 Cardiac Pacemakers, Inc. Implantable medical device with antenna
US20090182207A1 (en) 2008-01-16 2009-07-16 Tenxsys Inc. Ingestible animal health sensor
GB2456567B (en) 2008-01-18 2010-05-05 Oxford Biosignals Ltd Novelty detection
JP5132335B2 (ja) 2008-01-29 2013-01-30 富士フイルム株式会社 カプセル内視鏡及びカプセル内視鏡システム
JP5156427B2 (ja) 2008-02-13 2013-03-06 富士フイルム株式会社 カプセル内視鏡システム
DK2268261T3 (en) 2008-03-05 2017-08-28 Proteus Digital Health Inc Edible event markers with multi-mode communications and systems as well as methods for using them
CA2717057A1 (en) 2008-03-06 2009-09-11 Stryker Corporation Foldable, implantable electrode array assembly and tool for implanting same
US20090243833A1 (en) 2008-03-31 2009-10-01 Ching Ching Huang Monitoring system and method for patient care
EP2319389B1 (en) 2008-04-03 2014-02-26 Olympus Medical Systems Corporation Antenna unit and receiving apparatus for capsule medical apparatus
EP3260043A1 (en) 2008-04-21 2017-12-27 Carl Frederick Edman Metabolic energy monitoring system
AU2009260834B2 (en) 2008-06-18 2014-10-09 Covidien Lp System and method of evaluating a subject with an ingestible capsule
US20090318303A1 (en) 2008-06-20 2009-12-24 International Business Machines Corporation Microfluidic selection of library elements
US9014778B2 (en) 2008-06-24 2015-04-21 Biosense Webster, Inc. Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems
CH699071A2 (fr) 2008-07-02 2010-01-15 Flakes S A Dispositif de freinage et/ou de blocage mécanique.
EP2310989A4 (en) 2008-07-07 2013-03-13 Mario W Cardullo DYNAMICALLY DISTRIBUTABLE NANO-RFID DEVICE AND RELATED METHOD
SG10201702853UA (en) 2008-07-08 2017-06-29 Proteus Digital Health Inc Ingestible event marker data framework
EP2313003B1 (en) 2008-08-13 2016-08-03 Proteus Digital Health, Inc. Ingestible circuitry
US20100056878A1 (en) 2008-08-28 2010-03-04 Partin Dale L Indirectly coupled personal monitor for obtaining at least one physiological parameter of a subject
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US20100063841A1 (en) 2008-09-05 2010-03-11 Vital Data Technology, Llc System and method of notifying designated entities of access to personal medical records
US20100069002A1 (en) 2008-09-16 2010-03-18 Vcan Sports, Inc. Method and apparatus for a wireless communication device utilizing bluetooth technology
KR101192690B1 (ko) 2008-11-13 2012-10-19 프로테우스 디지털 헬스, 인코포레이티드 섭취 가능한 치료 활성화 시스템, 치료 장치 및 방법
TWI503101B (zh) 2008-12-15 2015-10-11 Proteus Digital Health Inc 與身體有關的接收器及其方法
MY153758A (en) * 2009-01-06 2015-03-13 Proteus Digital Health Inc Pharmaceutical dosages delivery system
US8395521B2 (en) 2009-02-06 2013-03-12 University Of Dayton Smart aerospace structures
US8073400B2 (en) 2009-02-17 2011-12-06 Rfaxis, Inc. Multi mode radio frequency transceiver front end circuit
US9035775B2 (en) 2009-02-25 2015-05-19 Xanthia Global Limited Wireless physiology monitor
US8452366B2 (en) 2009-03-16 2013-05-28 Covidien Lp Medical monitoring device with flexible circuitry
US8805528B2 (en) 2009-03-31 2014-08-12 Medtronic, Inc. Channel assessment and selection for wireless communication between medical devices
MX2011011506A (es) 2009-04-28 2012-05-08 Proteus Biomedical Inc Marcadores de eventos ingeribles altamente confiables y metodos para utilizar los mismos.
US9149423B2 (en) 2009-05-12 2015-10-06 Proteus Digital Health, Inc. Ingestible event markers comprising an ingestible component
US20110230732A1 (en) 2009-09-14 2011-09-22 Philometron, Inc. System utilizing physiological monitoring and electronic media for health improvement
US9075910B2 (en) 2010-03-11 2015-07-07 Philometron, Inc. Physiological monitor system for determining medication delivery and outcome
US9872637B2 (en) 2010-04-21 2018-01-23 The Rehabilitation Institute Of Chicago Medical evaluation system and method using sensors in mobile devices
US8596546B2 (en) 2010-06-14 2013-12-03 Trutag Technologies, Inc. System for verifying an item in a package
EP2580687A4 (en) 2010-06-14 2014-04-30 Trutag Technologies Inc SYSTEM FOR CHECKING AN ELEMENT IN A PACKAGE WITH A DATABASE
JP5855646B2 (ja) 2010-06-14 2016-02-09 トルタグ・テクノロジーズ・インコーポレーテッドＴｒｕｔａｇ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 識別子を伴うパッケージング商品を作成するためのシステム、商品のパッケージ、及び商品
CN103080923B (zh) 2010-06-14 2018-02-27 特鲁塔格科技公司 加标签和验证具有标识符的物品
WO2012035200A2 (en) 2010-09-13 2012-03-22 Nokia Corporation Haptic communication

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110799328A (zh) * 2017-05-03 2020-02-14 罗马科基利安有限公司 用于旋转式片剂压机的压制物品的出口设备及具有出口设备的旋转式片剂压机

Also Published As

Publication number Publication date
US8597186B2 (en) 2013-12-03
TW201603805A (zh) 2016-02-01
EP3395333A1 (en) 2018-10-31
WO2010080764A2 (en) 2010-07-15
AU2010203737A1 (en) 2011-07-21
US8951234B2 (en) 2015-02-10
SG172847A1 (en) 2011-08-29
EP2385827A4 (en) 2012-06-27
CA2750148A1 (en) 2010-07-15
CN102365084B (zh) 2014-04-30
IL213687A (en) 2015-07-30
HK1258442A1 (zh) 2019-11-15
AU2010203737B2 (en) 2016-09-15
TW201028140A (en) 2010-08-01
EP2385827A2 (en) 2011-11-16
KR20110104079A (ko) 2011-09-21
IL213687A0 (en) 2011-07-31
TWI602561B (zh) 2017-10-21
MY153758A (en) 2015-03-13
TWI544917B (zh) 2016-08-11
JP5785097B2 (ja) 2015-09-24
EP2385827B1 (en) 2018-07-04
JP2015177999A (ja) 2015-10-08
HK1165272A1 (zh) 2012-10-05
US20110306852A1 (en) 2011-12-15
WO2010080764A3 (en) 2010-10-21
US20140046147A1 (en) 2014-02-13
JP2012514499A (ja) 2012-06-28
CA2750148C (en) 2017-02-07

Similar Documents

Publication Publication Date Title
CN102365084B (zh) 药剂递送系统
US10207093B2 (en) Miniature ingestible device
Aleksovski et al. Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups
JP5869639B2 (ja) 摂取可能なイベントマーカの高生産性製造
JP6189403B2 (ja) 医薬品と一体化された摂取可能な事象マーカシステム
US7294346B2 (en) Medication delivery device
IL237809A (en) High-reliability, swallowable event markers and methods to use
US20060254580A1 (en) Digestible and volume adjustable multi medication delivery device
CN101730516A (zh) 用于口腔跨粘膜剂型给药的存储和分配装置
US20050053649A1 (en) Medication delivery device
US20050055013A1 (en) Medication delivery device
EP3076954B1 (en) Dosage form articles with multiple compartments

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1165272

Country of ref document: HK

C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: California, USA

Applicant after: PROTEUS BIOMEDICAL, Inc.

Address before: California, USA

Applicant before: PROTEUS BIOMEDICAL, Inc.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: PROTEUS BIOMEDICAL INC. TO: PROTEUS DIGITAL HEALTH, INC.

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1165272

Country of ref document: HK

TR01 Transfer of patent right

Effective date of registration: 20210615

Address after: American Maryland

Patentee after: Otsuka pharmaceutical Co.

Address before: California, USA

Patentee before: PROTEUS BIOMEDICAL, Inc.

Effective date of registration: 20210615

Address after: Tokyo, Japan

Patentee after: OTSUKA PHARMACEUTICAL Co.,Ltd.

Address before: American Maryland

Patentee before: Otsuka pharmaceutical Co.

TR01 Transfer of patent right