CN102338765A - Blood sugar testing paper - Google Patents
Blood sugar testing paper Download PDFInfo
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- CN102338765A CN102338765A CN2010106034677A CN201010603467A CN102338765A CN 102338765 A CN102338765 A CN 102338765A CN 2010106034677 A CN2010106034677 A CN 2010106034677A CN 201010603467 A CN201010603467 A CN 201010603467A CN 102338765 A CN102338765 A CN 102338765A
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- test paper
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Abstract
The invention belongs to the field of blood sugar test by using the electrode method. To overcome the technical problems that existing blood sugar testing paper is expensive, has high requirements for a preservation condition and a short period of validity, can only be used once, etc., the invention provides blood sugar testing paper which comprises a substrate, a working electrode and a counter electrode formed on the substrate, a circuit connected with the working electrode and the counter electrode and a composite material layer formed on the working electrode for reaction with a blood sample, wherein, the composite material layer comprises a polymer membrane and inorganic nanometer particles dispersed in and adhering to the polymer membrane.
Description
[technical field]
The present invention relates to a kind of blood sugar test paper, belong to electrode method blood sugar test field.
[background technology]
The existing diabetes patient of China is about 5,000 ten thousand, accounts for 1/4th of world diabetic sum, and annually also increases progressively in the quantity with 1,200,000 people.The rapid blood sugar appearance has been popularized in numerous diabetics and has been come as the indispensable instrument of diabetes monitoring.Commercially available rapid blood sugar appearance is divided into photochemical method and electrode method two big classes by principle of work.Wherein electrode method blood glucose meter needs blood volume few, and test result is fast, and is very easy to use.But, because itself there is the deficiency on the principle in the supporting test strips of commercially available blood glucose meter, test environment being had relatively high expectations, many patients, even the medical worker of some shortage specialized trainings can run into and detect inaccurate problem, thereby influence the observation of result of treatment.
The test philosophy of electrode method blood glucose meter is galvanochemistry three electrodes (or the two electrodes) method of testing of employing standard, and measuring process is cooperated by blood glucose meter and disposable test strips to be accomplished.Contain contrast electrode on the test strips, to electrode and three electrodes of working electrode (wherein, the test paper of two electrodes does not comprise contrast electrode, only uses electrode and two electrodes of working electrode).Scribble the biology enzyme of glucose response in the ability catalysis blood on the working electrode, like glucose oxidase or hexokinase, the electric signal that produces in the course of reaction is read and changes into the blood sugar concentration reading by blood glucose meter.Blood glucose meter is as a kind of electronic equipment of maturation, and the probability that itself breaks down is less.But the enzyme in the test strips is a bioactivator, costs an arm and a leg, and receive temperature easily, the interference of extraneous factor such as humidity, light, chemical substance and going bad; Therefore the preservation condition of test strips is had relatively high expectations; The term of validity is shorter, and can only disposablely use, and expense is higher.
[summary of the invention]
For this reason, the present invention's technical matters that will solve provide a kind of antijamming capability strong, be easy to the blood sugar test paper preserving and can be repeatedly used.
For solving the problems of the technologies described above, the invention provides a kind of blood sugar test paper.This test paper comprises substrate, is formed at on-chip working electrode, to electrode; Reach the circuit that electrode is linked to each other with said working electrode; And be formed on the working electrode, be used for the composite layer with blood sample reaction, it is characterized in that; This composite layer comprises: a polymer film and dispersion also adhere to the inorganic nanoparticles in this polymer film.
As preferably, this test paper can further comprise and disperse and adhere to the CNT in this polymer film, to increase electric signal, improve measurement sensitivity.
Wherein, the optional free nano-sized nickel hydroxide of said inorganic nanoparticles, nanometer copper, nano cupric oxide, nanometer nickel, nanometer platinum, nanometer palladium, or nm of gold.
Wherein, polymer film can be teflon, Kynoar, polyvinyl alcohol (PVA), cyclodextrin polymer, polythiophene, polythiaether, polyolefins, perfluorinated sulfonic resin, or polyaniline.
Wherein, this test paper can further comprise one be covered in working electrode and on the electrode as the hydrophilic membrane of reaction chamber.
Wherein, this test paper can further comprise the contrast electrode that links to each other with foregoing circuit.
As preferably, the thickness of this polymer film can be 1～300 micron.
Blood sugar test paper with respect to existing employing biology enzyme; The no enzyme test peper bar of employing inorganic nanoparticles-carbon nano tube-polymer Composite Preparation that the present invention proposes; Its antijamming capability in test process is strong; Test strips is easy to preserve, and can be repeatedly used (as can in one month, using repeatedly 100 times).Greatly facilitate diabetic's use, the test result accuracy rate is high simultaneously, and testing cost reduces greatly.
[description of drawings]
Fig. 1 is the structural representation of blood sugar test paper of the present invention.
Fig. 2 is the STRUCTURE DECOMPOSITION synoptic diagram of blood sugar test paper of the present invention.
[embodiment]
Illustrate further the present invention below in conjunction with specific embodiment.
Referring to Fig. 1 and Fig. 2; A kind of blood sugar test paper that the embodiment of the invention provides; Comprise substrate 10, be formed at on-chip working electrode 20, contrast electrode 30, to electrode 40 (being loop electrode), with said working electrode 20, contrast electrode 30 and circuit 50 that electrode 40 is linked to each other.
Be formed with a composite layer 60 on this working electrode, be used for reacting with blood sample.This composite layer 60 comprises: a polymer film and adhesion also are scattered in the inorganic nanoparticles in this polymer film.
In general, the thickness of polymer film does not have particular requirement, is preferably the 1-300 micron.Particularly, this polymer film can be perfluorinated sulfonic resin, teflon, Kynoar, polyvinyl alcohol (PVA), cyclodextrin polymer, polythiophene, polythiaether, polyolefins, polyaniline etc.
Should be noted that it is the nano material of shapes such as nanometer rods, nanometer sheet that defined inorganic nanoparticles also comprises on the microcosmic here.This inorganic nanoparticles does not have specific particle size range requirement, but should be within the nanoscale scope, i.e. 0.1～100 nanometer.Because in nanoscale, particles with different sizes or sheet, rod all have required activity, so, the nano particle of different-grain diameter, just activity varies in size, and can change according to real needs.This nano particle can directly disperse and adhere in the polymer film.In the present embodiment, this inorganic nanoparticles is a nano-sized nickel hydroxide, is used for substituting enzyme and the blood glucose response on the conventional test strips.In addition, this inorganic nanoparticles can also be a nanometer copper, nano cupric oxide, nanometer nickel, nanometer platinum, one or more of inorganic nano materials such as nanometer palladium and nm of gold.
This test paper can further comprise the CNT that is scattered in this polymer film, is used to increase electric signal, improves measurement sensitivity.Certainly under to the not high situation of accuracy requirement, also can not need CNT.
This polymer film is used for dispersing Nano carbon tubes, and dispersion and stabilized nanoscale nickel hydroxide, gets rid of the interference of other electroactive materials such as ascorbic acid etc. in the blood simultaneously, reduces the error in the blood sugar test process.
This test paper comprises that further one is covered in working electrode 20, contrast electrode 30 and on the electrode 40 as the hydrophilic membrane 70 of reaction chamber.
Should be pointed out that the present invention also comprises the test paper of two electrode classes, to be used for two electrode blood glucose monitoring systems.In the embodiment of two pole reagent papers, do not form contrast electrode 30 on this substrate 10.60 of composite layers are formed on the working electrode 20,70 of hydrophilic membranes be covered in working electrode 20 and on the electrode 40 as reaction chamber.
The no enzyme test peper bar of employing inorganic nanoparticles-carbon nano tube-polymer Composite Preparation that the present invention proposes; Its antijamming capability in test process is strong; The test result accuracy rate is high; And can be repeatedly used (as can in one month, using repeatedly 100 times), testing cost reduces greatly.Test strips is easy to preserve, and greatly facilitates diabetic's use.
Be noted that; Above-mentioned explanation only is the detailed description to preferred embodiment of the present invention; Narration is merely explanation realizability of the present invention and outstanding effect thereof; Concrete characteristic can not be used as the restriction to technical scheme of the present invention, and protection scope of the present invention should be as the criterion with appended claims of the present invention.
Claims (8)
1. a blood sugar test paper comprises substrate, is formed at on-chip working electrode; To electrode, reach the circuit that electrode is linked to each other with said working electrode, and be formed on the working electrode; Be used for composite layer with the blood sample reaction; It is characterized in that this composite layer comprises: a polymer film and dispersion also adhere to the inorganic nanoparticles in this polymer film.
2. test paper as claimed in claim 1 is characterized in that, this test paper further comprises dispersion and adheres to the CNT in this polymer film.
3. according to claim 1 or claim 2 test paper is characterized in that wherein said inorganic nanoparticles is selected from by nano-sized nickel hydroxide, nanometer copper, nano cupric oxide, nanometer nickel, nanometer platinum, nanometer palladium or nm of gold.
4. according to claim 1 or claim 2 test paper is characterized in that this polymer film is teflon perfluorinated sulfonic resin, Kynoar, polyvinyl alcohol (PVA), cyclodextrin polymer, polythiophene, polythiaether, polyolefins or polyaniline.
5. according to claim 1 or claim 2 test paper is characterized in that, this test paper further comprise one be covered in working electrode and on the electrode as the hydrophilic membrane of reaction chamber.
6. according to claim 1 or claim 2 test paper is characterized in that, this test paper further comprises the contrast electrode that links to each other with foregoing circuit.
7. test paper as claimed in claim 5 is characterized in that, this test paper comprises that further one is covered in working electrode, contrast electrode and on the electrode as the hydrophilic membrane of reaction chamber.
8. according to claim 1 or claim 2 test paper is characterized in that the thickness of this polymer film is 1～300 micron.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106034677A CN102338765A (en) | 2010-12-23 | 2010-12-23 | Blood sugar testing paper |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106034677A CN102338765A (en) | 2010-12-23 | 2010-12-23 | Blood sugar testing paper |
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| CN102338765A true CN102338765A (en) | 2012-02-01 |
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| CN2010106034677A Pending CN102338765A (en) | 2010-12-23 | 2010-12-23 | Blood sugar testing paper |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102636376A (en) * | 2012-03-20 | 2012-08-15 | 艾博生物医药(杭州)有限公司 | Solution for detecting analyte in sample |
| CN102928487A (en) * | 2012-10-19 | 2013-02-13 | 中国检验检疫科学研究院 | Plate-type working electrode and method for manufacturing same |
| CN104049012A (en) * | 2014-06-23 | 2014-09-17 | 西北工业大学 | Method for preparing cyclodextrin and nanogold modified glassy carbon electrode |
| CN104345074A (en) * | 2014-11-13 | 2015-02-11 | 东莞市青麦田数码科技有限公司 | Blood sugar test strip |
| CN105067685A (en) * | 2015-07-23 | 2015-11-18 | 武汉大学 | Blood multi-component detection test paper and preparation method thereof |
| CN106053571A (en) * | 2016-05-25 | 2016-10-26 | 辽宁大学 | Preparation and application of ionic liquid based polymerization liposome-gold nano-particle compound |
| CN106290517A (en) * | 2016-08-15 | 2017-01-04 | 中驭(北京)生物工程有限公司 | A kind of highly sensitive glucose is without enzyme sensor electrode material and preparation method thereof |
| CN109239157A (en) * | 2018-09-07 | 2019-01-18 | 常州大学 | A kind of non-enzyme sensor of graphene-NiO- polyaniline |
| CN115343348A (en) * | 2022-07-04 | 2022-11-15 | 深圳大学 | Method, device and equipment for detecting concentration of target object and storage medium |
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| US5762770A (en) * | 1994-02-21 | 1998-06-09 | Boehringer Mannheim Corporation | Electrochemical biosensor test strip |
| CN2748912Y (en) * | 2004-09-07 | 2005-12-28 | 桂林工学院 | Disposable electrode type blood sugar test bar |
| CN101303358A (en) * | 2007-05-10 | 2008-11-12 | 胡军 | Siphoning type blood sugar test paper |
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2010
- 2010-12-23 CN CN2010106034677A patent/CN102338765A/en active Pending
Patent Citations (3)
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| US5762770A (en) * | 1994-02-21 | 1998-06-09 | Boehringer Mannheim Corporation | Electrochemical biosensor test strip |
| CN2748912Y (en) * | 2004-09-07 | 2005-12-28 | 桂林工学院 | Disposable electrode type blood sugar test bar |
| CN101303358A (en) * | 2007-05-10 | 2008-11-12 | 胡军 | Siphoning type blood sugar test paper |
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| LING MENG ET AL: "Nonenzymatic Electrochemical Detection of Glucose Based on Palladium-Single-Walled Carbon Nanotube Hybrid Nanostructures", 《ANAL.CHEM.》 * |
| SABAHUDIN HRAPOVIC ET AL: "Electrochemical Biosensing Platforms Using Platinum Nanoparticles and Carbon Nanotubes", 《ANAL.CHEM.》 * |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102636376A (en) * | 2012-03-20 | 2012-08-15 | 艾博生物医药(杭州)有限公司 | Solution for detecting analyte in sample |
| CN102928487A (en) * | 2012-10-19 | 2013-02-13 | 中国检验检疫科学研究院 | Plate-type working electrode and method for manufacturing same |
| CN104049012A (en) * | 2014-06-23 | 2014-09-17 | 西北工业大学 | Method for preparing cyclodextrin and nanogold modified glassy carbon electrode |
| CN104049012B (en) * | 2014-06-23 | 2016-08-24 | 西北工业大学 | A kind of cyclodextrin and the preparation method of In Glassy Carbon Electrode Modified With Nano-gold |
| CN104345074B (en) * | 2014-11-13 | 2017-01-18 | 东莞市莞信企业管理咨询有限公司 | Blood sugar test strip |
| CN104345074A (en) * | 2014-11-13 | 2015-02-11 | 东莞市青麦田数码科技有限公司 | Blood sugar test strip |
| CN105067685A (en) * | 2015-07-23 | 2015-11-18 | 武汉大学 | Blood multi-component detection test paper and preparation method thereof |
| CN105067685B (en) * | 2015-07-23 | 2019-01-04 | 武汉大学 | A kind of blood multi-analyte immunoassay test paper and preparation method thereof |
| CN106053571A (en) * | 2016-05-25 | 2016-10-26 | 辽宁大学 | Preparation and application of ionic liquid based polymerization liposome-gold nano-particle compound |
| CN106053571B (en) * | 2016-05-25 | 2018-11-30 | 辽宁大学 | Ionic liquid base polyester plastid-gold nanoparticle compound preparation and application |
| CN106290517B (en) * | 2016-08-15 | 2018-11-02 | 中驭(北京)生物工程有限公司 | A kind of glucose of high sensitivity is without enzyme sensor electrode material and preparation method thereof |
| CN106290517A (en) * | 2016-08-15 | 2017-01-04 | 中驭(北京)生物工程有限公司 | A kind of highly sensitive glucose is without enzyme sensor electrode material and preparation method thereof |
| CN109239157A (en) * | 2018-09-07 | 2019-01-18 | 常州大学 | A kind of non-enzyme sensor of graphene-NiO- polyaniline |
| CN115343348A (en) * | 2022-07-04 | 2022-11-15 | 深圳大学 | Method, device and equipment for detecting concentration of target object and storage medium |
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Application publication date: 20120201 |