CN102183408A - Three-point or four-point bending fatigue test fixture for living rat ulna - Google Patents
Three-point or four-point bending fatigue test fixture for living rat ulna Download PDFInfo
- Publication number
- CN102183408A CN102183408A CN 201110060409 CN201110060409A CN102183408A CN 102183408 A CN102183408 A CN 102183408A CN 201110060409 CN201110060409 CN 201110060409 CN 201110060409 A CN201110060409 A CN 201110060409A CN 102183408 A CN102183408 A CN 102183408A
- Authority
- CN
- China
- Prior art keywords
- seaming chuck
- spring
- type
- point bending
- connecting rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention discloses a three-point or four-point bending fatigue test fixture for a living rat ulna. The fixture comprises a carrying disc and a foreleg uploading test device, wherein the carrying disc is arranged in a test chamber; the foreleg uploading test device comprises an upper connecting rod, an upper spring connection shaft, a linear elastic spring, a lower spring connection shaft, a T-shaped upper pressure head slide carriage, upper pressure heads, lower support heads, a C-shaped lower slide carriage and a lower connecting rod; the C-shaped lower slide carriage is mounted on the lower connecting rod connected with a main engine load sensor, and the upper end of the C-shaped lower slide carriage is provided with at least two guide pillars; a linear bearing capable of enabling the T-shaped upper pressure head slide carriage to move up and down along the guide pillars is mounted on the T-shaped upper pressure head slide carriage, the top of the T-shaped upper pressure head slide carriage is provided with the lower spring connection shaft connected with the lower end of the linear elastic spring, the upper end of the linear elastic spring is mounted on the lower end of the upper spring connection shaft, and the upper spring connection shaft is mounted at the lower end of the upper connecting rod; and one or more upper pressure heads are arranged under the T-shaped upper pressure head slide carriage, two lower support heads are arranged on the C-shaped lower slide carriage corresponding to the lower part of the upper pressure heads, and the carrying disc is mounted under the lower support heads. The fixture provided by the invention can take a living rat as a carrier, and is simple in structure, convenient to use, precise in acting points, accurate in location and more excellent in microdamage research, thereby being suitable for performing the three-point or four-point bending fatigue test on the living rat ulna.
Description
Technical field
The present invention relates to a kind of mechanism that clamps, 3 of especially a kind of live body mouse ulnas or four-point bending fatigue test clamper.
Background technology
The measurement of experiment made on the living mouse bone loading force mathematic(al) parameter is the basic research of setting up biomechanics of bone correlation theory and practical application, carry out clamping and utilize experiment made on the living mouse ulna to clamp mechanism, on Experiments of Machanics equipment, ulna is carried out dynamic and static loading experiment, can the load one adaptability to changes mathematic(al) parameter of test experiments mouse ulna under the different loads situation, draw the stress-strain curve of its ulna.Simultaneously, the various different loads of can further analyzing and researching produce tired micro-damage to experimental mouse ulna skeletal tissue, for correlation theory researchs such as biomechanics of bone, bone tissue engineer, pathology, pharmacology provide foundation.
At present experiment made on the living mouse bone loads Experiments of Machanics and mainly adopts two kinds of axial compression and four-point bending torture tests, state, inside and outside major part are to adopt the tired mode of axial compression to obtain sample micro-damage and fatigue fracture, as Chinese patent, the patent No. is: CN200910197437.8, patent name is: the patent of mechanism for axially loading and clamping ulna of in-vivo experimental rat, what adopt is the mode that a kind of experiment made on the living mouse ulna axially loads compression, but adopt the axial compression center of effort usually indeterminate, the micro-damage position is difficult for determining; And the tired location of four-point bending accurately, the tension force center of effort that deformation produced is clear and definite, can produce obvious micro-damage and stress fracture, it is indeterminate to have remedied a tension force center of effort that the property compression set is produced, micro-damage is not easy to shortcomings such as location, be of value to micro-damage research, but the device that clamps that does not also have four-point bending test at present, particularly do not adopt the four-point bending test device of live body, and requirement produces pure bending power in the four-point bending test between two upper pressure point, and shearing force is zero, and the dynamics on each pressure point must equate that technical difficulty is bigger, particularly do not have unit clamp for the live body rat, test is difficult to carry out.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art and provide a kind of simple in structure, easy to use, can adopt the live body mouse as carrier, center of effort accurately, accurate positioning, be used for 3 of the live body mouse ulnas or the four-point bending fatigue test clamper of micro-damage research better.
Purpose of the present invention is achieved by following technical proposals:
3 of a kind of live body mouse ulnas or four-point bending fatigue test clamper, comprise the loading dish and the forelimb load testing machine that are installed in the chamber, described forelimb load testing machine comprises upper connecting rod, coupling shaft on the spring, the linear elasticity spring, coupling shaft under the spring, T type seaming chuck slide, seaming chuck, the lower support head, C type lower slider, lower connecting rod, on the described lower connecting rod that described C type lower slider is installed in the main unit load sensor is connected, the upper end of described C type lower slider is provided with at least two guide pillars, the described linear bearing that described T type seaming chuck slide can be moved up and down along described guide pillar is installed on the described T type seaming chuck slide, the top of described T type seaming chuck slide is provided with coupling shaft under the described spring that is connected with described linear elasticity spring lower end, the upper end of described linear elasticity spring is installed in the lower end of coupling shaft on the described spring, coupling shaft is installed in the lower end of described upper connecting rod on the described spring, the below of described T type seaming chuck slide is provided with one or two seaming chuck, the below of corresponding described seaming chuck is provided with two lower support heads on the described C type lower slider, and described loading dish is installed in the below of described lower support head.
Among the present invention, the bracing frame that supports the loading dish also is installed in the described chamber, the lower end of support frame as described above is provided with stationary installation and is installed in the described chamber, the upper end of support frame as described above is provided with spiral lifting mechanism, the top of described spiral lifting mechanism is provided with slideway, and the lower end of described loading dish is provided with the guide rail that is installed in the described slideway.
Among the present invention, the below of described T type seaming chuck slide laterally is provided with chute, be provided with one or two seaming chuck in the described chute, described seaming chuck is fixed in the described chute by first holding screw and described seaming chuck can move at chute by the adjusting of described first holding screw.
Among the present invention, the below of described C type lower slider laterally is provided with chute, and described two lower support heads are fixed in the described chute by second holding screw and described lower support head can move at chute by the adjusting of described second holding screw.
Among the present invention, on the described lower support head hold down gag is installed, described hold down gag comprises set screw, compresses bracing frame, compressing tablet, the described bracing frame that compresses is fixed on the described lower support head, and described compressing tablet is connected and controls described compressing tablet and move up and down with the described bracing frame that compresses by set screw.
Adopt said structure, on the basis of existing bone electronics fatigue and damage experiment machine, this device is installed, can finish 3 of live body mouse ulnas or four-point bending torture test, set up live body rat ulna micro-damage model, be used for micro-damage research, after 3 in live body bone or four-point bending form micro-damage in addition, can pass through the uCT(minitype CT), equipment such as scanning electron microscope dynamic observe a series of indexs to be changed: form as the periosteum woven bone, bone remodeling, osteocyte apoptosis etc., particularly observe and be used for the treatment of the osteoporosis new drug more clinically (as parathyrotrophin, the diphosphonate preparation) the micro-dynamic change of each stage that micro-damage is repaired can be observed the pharmacology curative effect comprehensively meticulously, and this will be in the mechanism of inquiring into metabolic bone disease and fracture, early diagnosis and curative effect assessment aspect performance significant role.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Fig. 2 is the structural representation of side of the present invention.
Fig. 3 is the structural representation of Fig. 1 band bracing frame.
Accompanying drawing 1,2, in 3: 1-upper connecting rod, coupling shaft on 2-spring, 3-linear elasticity spring, coupling shaft under 4-spring, 5-guide pillar, 6-linear bearing, 7-T type seaming chuck slide, 8-the first holding screw, 9-seaming chuck, 10-lower support head, 11-loading dish, 12-guide rail, 13-C type lower slider, 14-spiral lifting mechanism, 15-lower connecting rod, 16-the second holding screw, 17-bracing frame, 18-chamber, 19-set screw, 20-compress bracing frame, 21-compressing tablet.
Embodiment
Below in conjunction with accompanying drawing, describe the embodiment of 3 of live body mouse ulnas or four-point bending fatigue test clamper in detail.
As shown in Figure 1, 2, these anchor clamps mainly are made up of loading dish 11 and forelimb load testing machine two parts.Loading dish 11 adopts corrosion resistant high-quality stainless steel material to make, and long 30 centimetres, wide 20 centimetres, its effect is after loading anesthesia, with two rats that movable ligature is fixedly to be tested.Loading dish 11 can move up and down by the spiral lifting mechanism 14 that is installed in chamber 18 bottoms, loading dish 11 bodies also can move forward and backward (over against the chamber front portion) along the slide rail 12 that is installed in spiral lifting mechanism 14 tops in addition, the rat of applicable not of uniform size, various body weight.
The forelimb load testing machine comprises coupling shaft 2 on upper connecting rod 1, the spring, linear elasticity spring 3, four-point bending test apparatus main body and lower connecting rod 15.Coupling shaft 2 is processed by the fine aluminum alloy on the spring, and coupling shaft 2 adopts the open type clearance fit to be connected with upper connecting rod 1 on the spring, and convenient disassembly is saved test period, improves test efficiency.Coupling shaft 2 belows are connected with linear elasticity spring 3 on the spring, and linear elasticity spring 3 forms with Hooke's law and the test overall construction design that the external force that causes deformation is directly proportional according to the deformation of object in elastic limit.Used linear elasticity spring 3 maximum loads of this device are 100N, and in displacement control or power control procedure, the distortion and the test power that show in real time in the control survey system can be controlled a live body rat left side (right side) forelimb load.
The below of described T type seaming chuck slide 7 is provided with one or two seaming chuck 9, if a seaming chuck 9 only is set, this device is the three-point bending fatigue test clamper, if two seaming chucks 9 are set, this device is the four-point bending fatigue test clamper, described seaming chuck 9 can the requirement according to correlation test pass through the 8 move left and right adjustment of first holding screw in T type seaming chuck slide 7, tightening first holding screw 8 after adjusting can be fixing with seaming chuck 9, lower support 10 also can be in C type lower slider 13 according to the requirement of correlation test by the 16 move left and right adjustment of second holding screw, it is fixing with lower support 10 to tighten second holding screw 16 after adjusting, seaming chuck 9 is adjusted distance in T type seaming chuck slide 7 be 0-20mm, lower support 10 is adjusted distance in C type lower slider 13 be 0-50mm, can solve a live body rat left side (right side) the forelimb problem different in size of testing like this.Lower connecting rod 15 upper ends are connected with C type lower slider 13, and lower connecting rod 15 lower ends are connected with the load-sensing unit load sensor.Test load is by upper connecting rod 1, coupling shaft 2 on the spring, linear elasticity spring 3, coupling shaft 4 is delivered on a live body rat left side (right side) forelimb between the interior lower support of the seaming chuck 9 that is placed in the T type seaming chuck slide 7 and C type lower slider 13 10 under the spring, and the load sensor that links to each other with lower connecting rod 15 is measured corresponding magnitude of load.
Among the present invention, described hold down gag comprises set screw 19, compresses bracing frame 20, compressing tablet 21, the described bracing frame 20 that compresses is fixed on the described lower support 10, described compressing tablet 21 is connected and controls described compressing tablet 21 and move up and down with the described bracing frame 20 that compresses by described set screw 19, pass through hold down gag, when the bigger mouse of build being cooked experiment, make a live body rat left side (right side) forelimb fixing more firm between seaming chuck and lower support head.
Claims (1)
1. 3 of live body mouse ulnas or four-point bending fatigue test clamper, comprise the loading dish (11) and the forelimb load testing machine that are installed in the chamber (18), it is characterized in that: described forelimb load testing machine comprises upper connecting rod (1), coupling shaft on the spring (2), linear elasticity spring (3), coupling shaft under the spring (4), T type seaming chuck slide (7), seaming chuck (9), lower support head (10), C type lower slider (13), lower connecting rod (15), described C type lower slider (13) is installed on the described lower connecting rod (15) that is connected with the main unit load sensor, the upper end of described C type lower slider (13) is provided with at least two guide pillars (5), the described linear bearing (6) that described T type seaming chuck slide (7) can be moved up and down along described guide pillar (5) is installed on the described T type seaming chuck slide (7), the top of described T type seaming chuck slide (7) is provided with coupling shaft (4) under the described spring that is connected with described linear elasticity spring (3) lower end, the upper end of described linear elasticity spring (3) is installed in the lower end of coupling shaft on the described spring (2), coupling shaft on the described spring (2) is installed in the lower end of described upper connecting rod (1), the below of described T type seaming chuck slide (7) is provided with one or two seaming chuck (9), the below that described C type lower slider (13) is gone up corresponding described seaming chuck (9) is provided with two lower support heads (10), and described loading dish (11) is installed in the below of described lower support head (10).
2. 3 of live body mouse ulnas according to claim 1 or four-point bending fatigue test clamper, it is characterized in that: the bracing frame (17) that supports loading dish (11) also is installed in the described chamber (18), the lower end of support frame as described above (17) is provided with stationary installation and is installed in the described chamber (18), the upper end of support frame as described above (17) is provided with spiral lifting mechanism (13), the top of described spiral lifting mechanism (13) is provided with slideway, and the lower end of described loading dish (11) is provided with the guide rail (12) that is installed in the described slideway.
3. 3 of live body mouse ulnas according to claim 1 and 2 or four-point bending fatigue test clamper, it is characterized in that: the below of described T type seaming chuck slide (7) laterally is provided with chute, be provided with one or two seaming chuck (9) in the described chute, described seaming chuck (9) is fixed in the described chute by first holding screw (8) and described seaming chuck (9) can move at chute by the adjusting of described first holding screw (8).
4. 3 of live body mouse ulnas according to claim 1 and 2 or four-point bending fatigue test clamper, it is characterized in that: the below of described C type lower slider (13) laterally is provided with chute, and described two lower support heads (10) are fixed in the described chute by second holding screw (16) and described lower support head (10) can move at chute by the adjusting of described second holding screw (16).
5. 3 of live body mouse ulnas according to claim 1 and 2 or four-point bending fatigue test clamper is characterized in that: on the described lower support head (10) hold down gag is installed.
6. 3 of live body mouse ulnas according to claim 5 or four-point bending fatigue test clamper, it is characterized in that: described hold down gag comprises set screw (19), compresses bracing frame (20), compressing tablet (21), the described bracing frame (20) that compresses is fixed on the described lower support head (10), and described compressing tablet (21) is connected and controls described compressing tablet (21) and move up and down with the described bracing frame (20) that compresses by described set screw (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100604099A CN102183408B (en) | 2011-03-14 | 2011-03-14 | Three-point or four-point bending fatigue test fixture for living rat ulna |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100604099A CN102183408B (en) | 2011-03-14 | 2011-03-14 | Three-point or four-point bending fatigue test fixture for living rat ulna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102183408A true CN102183408A (en) | 2011-09-14 |
| CN102183408B CN102183408B (en) | 2012-07-25 |
Family
ID=44569635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100604099A Expired - Fee Related CN102183408B (en) | 2011-03-14 | 2011-03-14 | Three-point or four-point bending fatigue test fixture for living rat ulna |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102183408B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103926158A (en) * | 2013-01-16 | 2014-07-16 | 南京理工大学 | Cartilage creep mechanical performance testing device |
| CN104007010A (en) * | 2014-05-20 | 2014-08-27 | 湖南大学 | Horizontal impact type damage biomechanics dynamic three-point bending testing device |
| CN107271271A (en) * | 2017-06-30 | 2017-10-20 | 东南大学 | A kind of ancillary test device for being exclusively used in the research of small rod flexural property |
| CN107917844A (en) * | 2018-01-16 | 2018-04-17 | 天津工业大学 | A kind of 3 points of composite material, four-point bending fatigue universal test fixture |
| CN108051317A (en) * | 2017-12-26 | 2018-05-18 | 安徽开诚电器有限公司 | A kind of bend testing apparatus of appliance switch element |
| CN108717023A (en) * | 2018-07-17 | 2018-10-30 | 东北大学 | The device and method of magnesium alloy plate and belt beaming limit and springback capacity is tested simultaneously |
| CN110006790A (en) * | 2019-04-09 | 2019-07-12 | 中国人民解放军总医院 | Cartilage permeability measurement apparatus and measurement method |
| CN110907297A (en) * | 2019-12-26 | 2020-03-24 | 北京航空航天大学 | Three-point bending fatigue test device applied to displacement loading |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6199508B1 (en) * | 1998-06-22 | 2001-03-13 | Theresa Miale | Animal lift and transport apparatus |
| CN2432890Y (en) * | 2000-07-28 | 2001-06-06 | 湖南医科大学附属第二医院 | Impact device for hone fatigue test |
| US20030111021A1 (en) * | 2001-12-13 | 2003-06-19 | Ru-Ping Lee | Animal experiment method |
| CN101158679A (en) * | 2007-11-23 | 2008-04-09 | 清华大学 | Extract and mechanical properties measurement method of bone trabecula and measurement mechanism |
| CN101637382A (en) * | 2008-07-28 | 2010-02-03 | 上海中医药大学附属曙光医院 | Vertebral rigidity measuring device for rat vertebral subluxation animal model |
| CN101694442A (en) * | 2009-10-20 | 2010-04-14 | 上海理工大学 | Mechanism for axially loading and clamping ulna of in-vivo experimental rat |
| US7784429B2 (en) * | 2006-09-22 | 2010-08-31 | Chiodo Chris D | Contoured specimen holder for imaging machines |
| CN201622205U (en) * | 2010-02-09 | 2010-11-03 | 上海理工大学 | Shin axial force-loading clamping mechanism for rats |
-
2011
- 2011-03-14 CN CN2011100604099A patent/CN102183408B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6199508B1 (en) * | 1998-06-22 | 2001-03-13 | Theresa Miale | Animal lift and transport apparatus |
| CN2432890Y (en) * | 2000-07-28 | 2001-06-06 | 湖南医科大学附属第二医院 | Impact device for hone fatigue test |
| US20030111021A1 (en) * | 2001-12-13 | 2003-06-19 | Ru-Ping Lee | Animal experiment method |
| US7784429B2 (en) * | 2006-09-22 | 2010-08-31 | Chiodo Chris D | Contoured specimen holder for imaging machines |
| CN101158679A (en) * | 2007-11-23 | 2008-04-09 | 清华大学 | Extract and mechanical properties measurement method of bone trabecula and measurement mechanism |
| CN101637382A (en) * | 2008-07-28 | 2010-02-03 | 上海中医药大学附属曙光医院 | Vertebral rigidity measuring device for rat vertebral subluxation animal model |
| CN101694442A (en) * | 2009-10-20 | 2010-04-14 | 上海理工大学 | Mechanism for axially loading and clamping ulna of in-vivo experimental rat |
| CN201622205U (en) * | 2010-02-09 | 2010-11-03 | 上海理工大学 | Shin axial force-loading clamping mechanism for rats |
Non-Patent Citations (1)
| Title |
|---|
| 《生物医学工程学杂志》 20061231 戴如春等 SL_2000骨疲劳损伤实验机的研制与应用 第192-195页 1-6 第23卷, 第1期 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103926158A (en) * | 2013-01-16 | 2014-07-16 | 南京理工大学 | Cartilage creep mechanical performance testing device |
| CN103926158B (en) * | 2013-01-16 | 2016-04-27 | 南京理工大学 | A kind of cartilage Creep Mechanics performance testing device |
| CN104007010A (en) * | 2014-05-20 | 2014-08-27 | 湖南大学 | Horizontal impact type damage biomechanics dynamic three-point bending testing device |
| CN107271271A (en) * | 2017-06-30 | 2017-10-20 | 东南大学 | A kind of ancillary test device for being exclusively used in the research of small rod flexural property |
| CN107271271B (en) * | 2017-06-30 | 2019-07-12 | 东南大学 | A kind of ancillary test device being exclusively used in the research of small rod flexural property |
| CN108051317A (en) * | 2017-12-26 | 2018-05-18 | 安徽开诚电器有限公司 | A kind of bend testing apparatus of appliance switch element |
| CN107917844A (en) * | 2018-01-16 | 2018-04-17 | 天津工业大学 | A kind of 3 points of composite material, four-point bending fatigue universal test fixture |
| CN108717023A (en) * | 2018-07-17 | 2018-10-30 | 东北大学 | The device and method of magnesium alloy plate and belt beaming limit and springback capacity is tested simultaneously |
| CN108717023B (en) * | 2018-07-17 | 2023-10-27 | 东北大学 | Device and method for simultaneously testing bending limit and resilience of magnesium alloy plate and strip |
| CN110006790A (en) * | 2019-04-09 | 2019-07-12 | 中国人民解放军总医院 | Cartilage permeability measurement apparatus and measurement method |
| CN110907297A (en) * | 2019-12-26 | 2020-03-24 | 北京航空航天大学 | Three-point bending fatigue test device applied to displacement loading |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102183408B (en) | 2012-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102183408B (en) | Three-point or four-point bending fatigue test fixture for living rat ulna | |
| CN104792611B (en) | Concrete compression bursting stress strain full curve test device | |
| CN201464292U (en) | Clamp for tests on porous light-weight materials | |
| CN107941613B (en) | Multifunctional testing integrated instrument for biological reaction and soft tissue mechanics | |
| CN109187181A (en) | Bone tissue-metal implant complex in-situ mechanical test device and method | |
| CN107440743A (en) | Ultrasonic probe adjustment mechanism and ultrasonic detection robot | |
| CN205450030U (en) | Device of normal position microscopic mechanics , micro -structure, composition integration research carries out in scanning electron microscope | |
| EP2083260A3 (en) | Component surface inspection method and device | |
| CN104390576B (en) | A kind of mechanical welding deformation measuring device and Bus Frame Joint Welding optimization method | |
| CN103293058A (en) | Crack monitoring device and crack monitoring method | |
| CN102323279A (en) | X-ray tomography-based in-situ loading device | |
| CN111929154A (en) | In-situ nano indentation testing device and method | |
| CN206880695U (en) | Ultrasonic probe adjustment mechanism and ultrasonic detection robot | |
| CN104075945B (en) | Anchoring structure rheological testing machine and method for simulating rheological properties of geologic structure body by utilizing machine | |
| CN205643054U (en) | High cloth formula sclerometer of security | |
| CN202101953U (en) | In-situ loading device based on X-ray tomography | |
| CN209372551U (en) | A kind of steel and concrete structure test specimen Special bending, scissor test loading device | |
| CN104007010B (en) | A kind of horizontal impact formula injury biomechanics dynamic three point bending test device | |
| CN209513423U (en) | A kind of tubular part hardness measurement fixture | |
| CN208187945U (en) | A kind of loading device for bond-slip properties test | |
| KR20100000814U (en) | Magnetic flaw detector | |
| CN109269925A (en) | A kind of hardness test device of oilless bearing | |
| CN111351703A (en) | Skeletal mechanics loading tester capable of synchronous CT imaging | |
| CN214539055U (en) | A device for brinell hardness test | |
| CN206990324U (en) | Formation tester test stand |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120725 Termination date: 20150314 |
|
| EXPY | Termination of patent right or utility model |