CN102128918A - Detecting test paper - Google Patents
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- CN102128918A CN102128918A CN201010542684XA CN201010542684A CN102128918A CN 102128918 A CN102128918 A CN 102128918A CN 201010542684X A CN201010542684X A CN 201010542684XA CN 201010542684 A CN201010542684 A CN 201010542684A CN 102128918 A CN102128918 A CN 102128918A
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- 238000012360 testing method Methods 0.000 title claims abstract description 69
- 239000007788 liquid Substances 0.000 claims abstract description 186
- 238000001514 detection method Methods 0.000 claims description 51
- 239000000463 material Substances 0.000 claims description 37
- 238000006243 chemical reaction Methods 0.000 claims description 21
- 238000000926 separation method Methods 0.000 claims description 9
- 230000004888 barrier function Effects 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
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- 210000004369 blood Anatomy 0.000 abstract description 11
- 238000007705 chemical test Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 98
- 239000003153 chemical reaction reagent Substances 0.000 description 26
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- 238000005534 hematocrit Methods 0.000 description 6
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 239000000020 Nitrocellulose Substances 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 3
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 3
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- 238000002835 absorbance Methods 0.000 description 2
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- 230000002596 correlated effect Effects 0.000 description 2
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Abstract
The invention relates to a detecting test paper, in particular to a dry chemical test paper for detecting the content of the analyzed object in the blood sample. The detecting test paper comprises a sample adding layer, a reacting layer, a base plate and a liquid-locking component, wherein the sample adding layer, the reacting layer and the base plate are vertically arranged from the top to bottom; at least one side of the reacting layer is provided with the liquid-locking component; and the speed of the liquid-locking component for absorbing the liquid is less than or equal to the speed of the reacting layer for absorbing the liquid. As the liquid-locking component is capable of absorbing the redundant liquid sample, the redundant sample does not flow out of the range of the test paper, and the phenomenon of polluting the environment or the sample contacting to the detector is avoided.
Description
Technical field
The present invention relates to a kind of clinical detection technique field, especially a kind of drying chemical reagent paper that detects blood sample mesophytization index.
Background technology
At present, be used for detecting the method whether blood exist certain composition or this component content and comprise that liquid reagent detects and the drying chemical reagent paper detection.That drying chemical reagent paper has is easy to use, simple to operate, go out result's characteristics fast.
According to the flow path of tracer liquid sample on drying chemical reagent paper, drying chemical reagent paper can be divided into polytype, vertically the vertical detection test paper is a kind of of drying chemical reagent paper.Vertically the vertical detection test paper comprise will have a reaction reagent the carrier mutual superposition together, top-down each reaction reagent layer of flowing through of liquid sample finally shows testing result.For example U.S. Pat 4816224 adopts the method for vertical vertical detection test paper.
Vertically the area of its reaction reagent carrier of vertical detection test paper is all less, therefore only needs less liquid sample consumption just can finish detection.Because individual difference, in the process of finger tip blood sampling, the sample size of collection is to be difficult to control, and for example, occidentals's finger tip blood sampling volume tends to more than the Asian.And the reaction reagent carrier saturation degree certain to being absorbed with of liquid, when the blood sample of dropping on test paper was too much, existing dry chemical detects test paper can not in time handle unnecessary blood sample.Of the prior art vertical vertical detection test paper as shown in Figure 1, this test paper comprises: base plate 2 adheres to and is supporting responding layer 1, is coated with sample separation layer 4, fiberglass layer 3 and clathrum 5 on the responding layer.Vertical current finally arrives responding layer 1 chemical reaction takes place through fiberglass layer 3 and sample separation layer 4 after fluid drips is added to clathrum 5.If the blood sample amount that adds is more, when the responding layer that reaches hold-up can not absorb unnecessary sample again, these unnecessary blood samples will overflow the detection test paper, contaminated environment or touch the tester.Unnecessary blood also can accumulate in and form drop on the reaction reagent layer, not only influences the interpretation of detecting instruments such as optics to the result, pollution detection instrument that also can be serious.
Summary of the invention
The object of the present invention is to provide a kind of easy to use, and drying chemical reagent paper that can the unnecessary liquid sample of fast processing.
Drying chemical reagent paper of the present invention comprises on the base plate 11 and to adhere to and to support responding layer 12, is coated with application of sample layer 13 in responding layer with respect to the opposite side of base plate, and an application of sample mouth 14 is arranged on the application of sample layer.Responding layer is overlapping lock liquid parts 15 along at least one side of base plate direction, and lock liquid parts are fixed on the base plate.With respect to responding layer 12 places one detection window 16 that is used to read reaction result is arranged at base plate.Can also be between responding layer, application of sample layer, lock liquid parts and the base plate by the position between the more firm fixing them of bonding sheet 17.For example, the adhesion that bonding sheet 17 is continuous also is pressed on application of sample layer, lock liquid parts and the base plate, thereby makes responding layer, application of sample layer, lock liquid parts and base plate mutual alignment fix.
The speed that described lock liquid parts absorb liquid is less than or equal to the speed that responding layer absorbs liquid.When liquid sample was added to the application of sample layer, elder generation vertically flowed into responding layer and is absorbed by responding layer.When the responding layer hold-up, liquid is diffused in the lock liquid parts that overlap with responding layer by the mode of horizontal effluent.Because lock liquid parts absorb the absorption liquid velocity that the speed of liquid is less than or equal to responding layer, so when unnecessary liquid is diffused into lock liquid parts, the detection reaction that liquid on the responding layer enough has been correlated with, thus the required effective dose of detection reaction do not influenced.When adding excessive sample, unnecessary sample is locked the liquid parts and is absorbed, and therefore unnecessary sample can not form drop and overflows outside the test paper.
The invention has the beneficial effects as follows that lock liquid parts can absorb the excess liquid sample, make unnecessary sample can not flow out the test paper scope, have avoided environment and detecting instrument are polluted or touch the tester.And the Liquid Absorption speed of lock liquid parts is less than the Liquid Absorption infiltration rate of responding layer, and having guaranteed like this has enough liquid samples that is used to detect on the responding layer when unnecessary sample is locked the absorption of liquid portion, guaranteed that testing result is stable, accurate.
Description of drawings
Fig. 1 is a detection test paper structural representation of the prior art;
Fig. 2 is that the present invention detects the test paper structural representation for first kind;
Fig. 3 is that the present invention detects the test paper decomposing schematic representation for first kind;
Fig. 4 is that the present invention detects the test paper structural representation for second kind;
Fig. 5 is the third detection test paper structural representation of the present invention;
Fig. 6 is that the present invention detects the test paper structural representation for the 4th kind;
Fig. 7 is that the present invention detects the test paper decomposing schematic representation for the 5th kind;
Fig. 8 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid unit construction;
Fig. 9 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid unit construction;
Figure 10 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid unit construction;
Figure 11 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid unit construction;
Figure 12 is the decomposing schematic representation of a kind of responding layer of the present invention and lock liquid unit construction.
Embodiment
The present invention will be described in detail below in conjunction with concrete accompanying drawing.These specific embodiments only are limited the enumerating under spirit of the present invention, do not get rid of one of ordinary skill in the art prior art and the present invention in conjunction with and other specific embodiments of producing.
Shown in Fig. 2-3, drying chemical reagent paper of the present invention comprises base plate 11, responding layer 12 and lock liquid parts 15.Responding layer 12 and lock liquid parts 15 are placed on the same side of base plate 11 and are contiguous mutually.Include detectable on the responding layer 12, be used to receive liquid sample, and with liquid sample reaction after draw testing result.Lock liquid parts 15 are positioned in the next door of responding layer 12, are used to absorb excessive liquid sample, detect health more thereby make.One or more lock liquid parts 15 can be settled in the next door of responding layer 12, when a plurality of lock liquid parts, these lock liquid parts 15 are that the center is symmetrical placement or is regular polygon with responding layer 12 preferably, as settings such as equilateral triangle, square, regular pentagon, regular hexagons, so further improve the beneficial effect that lock liquid parts absorb excessive liquid sample.Lock liquid parts 15 also can be middle porose monoblocks, and responding layer 12 is placed in the hole and by lock liquid parts 15 and surrounds (as shown in figure 12).Responding layer 12 and lock liquid parts 15 can be fixed on the base plate 11 by glue, double faced adhesive tape or alternate manner, and responding layer 12 can contact side by side or overlap up and down with lock liquid parts 15, also can be intercepted and not contacted by the space.Liquid sample directly is added on the responding layer 12, and the excess liquid sample is absorbed by lock liquid parts 15.
In another embodiment, shown in Fig. 3-5, be coated with application of sample layer 13 in responding layer 12 with respect to the opposite side of base plate 11, the end of application of sample layer 13 can contact side by side with lock liquid parts 15 or overlap joint up and down, also can be intercepted and not contacted by the space.Can also pass through bonding sheet 17 position between the fixing them more firmly between responding layer 12, application of sample layer 13, lock liquid parts 15 and the base plate 11.For example, the adhesion that bonding sheet 17 is continuous also is pressed on application of sample layer 13, lock liquid parts 15 and the base plate 11, thereby makes responding layer 12, application of sample layer 13, lock liquid parts 15 and base plate 11 mutual alignments fix.Bonding sheet 17 is impermeable materials, and not bonded 17 place that covers of application of sample layer 13 is formed with an application of sample mouth 14.With respect to responding layer 12 places one detection window 16 that is used to read reaction result is arranged at base plate 11.
The speed that described lock liquid parts absorb liquid is less than or equal to the speed that responding layer absorbs liquid.On the one hand, responding layer is shorter to application of sample layer path than lock liquid parts to the path of application of sample layer, and the liquid sample that drips on the application of sample layer arrives responding layer earlier; On the other hand, the speed of the selected absorbed liquid of lock liquid parts is less than or equal to the speed of the selected absorbed liquid of responding layer.When liquid sample was added to the application of sample layer, elder generation vertically flowed into responding layer and is absorbed by responding layer.When the responding layer hold-up, liquid is diffused in the lock liquid parts by the mode of horizontal effluent.Because lock liquid parts absorb the absorption liquid velocity that the speed of liquid is less than or equal to responding layer, so when unnecessary liquid is diffused into lock liquid parts, the detection reaction that liquid on the responding layer enough has been correlated with, thus the required effective dose of detection reaction do not influenced.When adding excessive sample, unnecessary sample is locked the liquid parts and is absorbed, and therefore unnecessary sample can not form drop and overflows outside the test paper.
Detection test paper as shown in Figure 4, at least one end parts of application of sample layer 13 has covered lock liquid parts 15.It is shorter than the path that arrives lock liquid parts that liquid sample arrives the path of responding layer, because the application of sample mouth be positioned at responding layer directly over, arriving responding layer and have only the distance of perpendicular flow, is to diffuse laterally into lock liquid parts top and then the vertical lock liquid parts that flow into earlier and arrive lock liquid parts.On the other hand, responding layer is selected for use and is locked liquid parts identical materials or select than the stronger material of lock liquid parts absorption liquid ability.Because described lock liquid parts absorb the speed that the speed of liquid is less than or equal to the absorption liquid of responding layer, so when unnecessary liquid was diffused into lock liquid parts, the amount of liquid on the responding layer had enough satisfied the relevant consumption of detection.When adding excessive sample, unnecessary sample is locked the liquid parts and is absorbed.
Among the embodiment as shown in Figure 5, between responding layer 12 and the lock liquid parts 15 not liquid communicate.Liquid does not communicate and can realize by the mode that has slit or interpolation spacing block between the two.Among the embodiment as described in Figure 5, lock liquid parts 15 cut off with responding layer 12 usefulness barrier blocks 18, and liquid does not communicate between them, and barrier blocks is impermeable mucilage materials.The present invention comprises that also those skilled in the art can expect making other modes that liquid communication does not take place between lock liquid parts and the responding layer.Application of sample layer 13 at least one end parts have covered lock liquid parts 15, and when adding excessive liquid, excess liquid is locked the liquid parts by the transverse dispersion arrival of responding layer and is absorbed.
Detection test paper as shown in Figure 6, between responding layer 12 and application of sample layer 13, also comprise at least one sample separation layer 19, described sample separation layer is used for the interfering material and the detected material of liquid sample are separated, and stops interfering material to enter responding layer and contacts with chemical reagent on the responding layer.
Lock liquid parts can also be bonded with double faced adhesive tape up and down, and its thickness is 0.1mm, described double faced adhesive tape be used for lock liquid parts respectively with application of sample layer and more firm the combining of base plate.
When lock liquid parts 15 of the present invention adopted as the described embodiment of Fig. 2-6, selected material was any material of energy absorption liquid sample body, for example filter paper, cellulose nitrate, nonwoven fabrics etc., preferably filter paper.The thickness of lock liquid parts determines according to the different structure that detects sample type and test paper, and is preferably contour or be slightly less than the height of responding layer with responding layer.
The material that base plate 11 of the present invention is not liquid permeable samples constitutes, and described material is selected from polypropylene, polystyrene, plastic sheet etc.
Application of sample layer 13 selected material of the present invention are possess hydrophilic property or the material of doing hydrophilic treatment, and it can spread and permeate the sample that adds fast.Described material comprises nylon, glass fibre, nonwoven fabrics, polyester film, filter paper and other suitable materials.
Sample separation layer 19 of the present invention detects irrelevant interfering material in order to separate with analyte.The material of described separating layer is selected from suitable materials such as cellulose nitrate, glass fibre, filter paper, nonwoven fabrics, polyester film.Separating layer can be crossed with chemical substance physics or not treated direct use in advance.
Embodiment as described in Figure 7, lock liquid parts 15 are a kind of capillary devices that have.Described lock liquid parts 15 comprise the capillary channel 20 of an orientating reaction layer 12, when the liquid sample that adds is excessive, the excess liquid sample is drawn under capillarity in the capillary channel 20 of lock liquid parts rapidly, makes it not excessive thereby pin unnecessary sample.The material of the described lock liquid of present embodiment parts 15 can be plastics etc.
A plurality of (more than two and two) responding layer 12 also can be arranged on the base plate 11, can place identical or dissimilar detectable on each responding layer 12, so that carry out a plurality of identical or dissimilar detections simultaneously, thereby improve detection efficiency, save and detect cost.When a plurality of responding layer 12 is arranged on the base plate 11, preferably leave the gap between these responding layers 12 each other.The next door of each responding layer 12 can be mounted with lock liquid parts 15 at least.The positional alignment mode of responding layer 12 and lock liquid parts 15 please refer to Fig. 8-12, and (for for simplicity, Fig. 8-12 only illustrates responding layer 12 and locks liquid parts 15, and will omit such as base plate 11 elements such as grade.Also should comprise base plate 11 and other necessary element in the actual design).
As shown in Figure 8, responding layer 12 and lock liquid parts 15 are arranged in a row on base plate 11, and each responding layer 12 2 side all has lock liquid parts 15.
As shown in Figure 9, responding layer 12 and lock liquid parts 15 on base plate 11 successively the compartment of terrain be arranged in a row, lock liquid parts 15 are arranged between adjacent two responding layers 12, between adjacent two lock liquid parts 15 responding layer 12 is arranged.
As shown in figure 10, having two rows on the base plate 11 locks liquid parts 15 and is sandwiched in two row's responding layers 12 of arranging between the lock liquid parts 15.
As shown in figure 11, having two strips that are arranged side by side on the base plate 11 locks liquid parts 15 and is sandwiched in two row's responding layers 12 between the strips lock liquid parts 15.
As shown in figure 12, have strip lock liquid parts 15 on the base plate 11, have a round on the strip lock liquid parts 15, be mounted with a responding layer 12 in each hole.
In addition, as required, upper and lower two of base plate 11 all can be provided with responding layer 12 and lock liquid parts 15, thereby can settle more responding layer 12 on base plate 11 of the same area, so that same product carries out more multinomial detection.
Said liquid sample comprises liquid sample and the sample that is dissolved in the liquid in this specification and claims book.
A kind of drying chemical reagent paper of embodiment 1 the present invention
Dry chemical of the present invention detects test paper, as shown in Figure 4, adheres to and supporting responding layer 12 on the base plate 11, is coated with application of sample layer 13 in responding layer with respect to the opposite side of base plate, and an application of sample mouth 14 is arranged on the application of sample layer.The two end portions of application of sample layer 13 has covered lock liquid parts 15.With respect to responding layer 12 places detection window 16 is arranged at base plate.The adhesion that bonding sheet 17 is continuous also is pressed on application of sample layer, lock liquid parts and the base plate.Base plate 11 adopts the PET material, and thickness is 0.35mm.Responding layer 12 adopts the nylon membrane material, and thickness is 0.05mm.Application of sample layer 13 adopts the glass polymeric material.Lock liquid parts 15 adopt filter paper material, and thickness is 0.4mm.Sample separation layer 19 thickness are 0.35mm.
Application of sample amount cholesterol detection on drying chemical reagent paper of the present invention that embodiment 2 is different
The preparation cholesterol concentration is the whole blood solution of 150mg/dl, and wherein the hematocrit of this sample (HCT) concentration is 42%.Get the above-mentioned whole blood solution of 15 μ l, 20 μ l, 30 μ l and 40 μ l respectively, be added drop-wise on the embodiment of the invention 1 described drying chemical reagent paper and detect.When the sample consumption reached 20 μ l, the absorbance log of the embodiment of the invention 1 its responding layer test paper of described drying chemical reagent paper reached capacity.The sample consumption is considered to excessive application of sample amount when being 30 μ l and 40 μ l.Test result shows that drying chemical reagent paper of the present invention is not subjected to the influence of application of sample amount, can well absorb unnecessary sample.Testing result is stable, accurate.Testing result sees Table 1.
Table 1
Embodiment 3 different application of sample amounts are tested by the influence of HCT concentration
Prepare hematocrit (HCT) respectively and be 30%, 42%, 55% whole blood solution, be added drop-wise on the embodiment of the invention 1 described drying chemical reagent paper and detect.The application of sample amount is respectively 15ul, 20ul, 30ul, 40ul.When the sample consumption reached 20 μ l, the absorbance log of the embodiment of the invention 1 its responding layer test paper of described drying chemical reagent paper reached capacity.The sample consumption is considered to excessive application of sample amount when being 30 μ l and 40 μ l.The result shows, uses drying chemical reagent paper of the present invention, is not subjected to the influence of hematocrit, also is not subjected to the influence of application of sample amount, and testing result is stable, consistent.The results are shown in Table 2 to table 4.
Table 2
Table 3
Table 4
In order to support better the claim book, for later modification right requires book that foundation is provided, the present invention's disclosed content when filing an application is supplemented as follows.
1, a kind of Test paper comprises base plate (11) and is positioned at conversion zone (12) on the base plate that it is characterized in that: at least one side in conversion zone (12) includes be used to the lock liquid parts (15) that absorb unnecessary liquid.
2, Test paper according to claim 1 is characterized in that: the speed that lock liquid parts (15) absorb liquid less than or equal the speed that conversion zone (12) absorbs liquid.
3, Test paper according to claim 1 is characterized in that: lock liquid parts (15) that are used for absorbing unnecessary liquid are respectively arranged in the relative both sides of conversion zone (12).
4, Test paper according to claim 1, it is characterized in that: Test paper also comprises being positioned at and adds sample layer (13) on the conversion zone (12), adds sample layer (13) and contact side by side, mutually overlaps or do not contact mutually with lock liquid parts (15).
5, detection test paper according to claim 4 is characterized in that: contact side by side or overlap mutually between responding layer (12) and lock liquid parts (15).
6, detection test paper according to claim 4 is characterized in that: intercepted by the gap between responding layer (12) and the lock liquid parts (15) or intercepted by fluid-tight barrier blocks (18).
7, detection test paper according to claim 4 is characterized in that: also comprise at least one sample separation layer (19) between application of sample layer and the responding layer.
8, detection test paper according to claim 1 is characterized in that: lock liquid parts (15) have capillary channel (20) at an end of orientating reaction layer (12), and the material of described lock liquid parts (15) is a material impervious to water.
9, detection test paper according to claim 1 is characterized in that: responding layer (12) is surrounded by the lock liquid parts (15) more than three or three, and these lock liquid parts (15) are that the center is the regular polygon layout with responding layer (12).
10, detection test paper according to claim 1 is characterized in that: the size of lock liquid parts (15) is bigger than responding layer (12), and there is a hole inside, and responding layer (12) is enclosed in the hole of locking the liquid parts.
11, detection test paper according to claim 1 is characterized in that: the responding layer (12) more than two or two is arranged on the base plate (11), and the next door of each responding layer (12) is equipped with at least one lock liquid parts (15).
12, detection test paper according to claim 11 is characterized in that: responding layer (12) and lock liquid parts (15) are arranged in a row on base plate (11), and each responding layer (12) two side all has lock liquid parts (15).
13, detection test paper according to claim 11, it is characterized in that: responding layer (12) and the lock liquid parts (15) on base plate (11) successively the compartment of terrain be arranged in a row, lock liquid parts (15) are arranged between adjacent two responding layers (12), between adjacent two lock liquid parts (15) responding layer (12) is arranged.
14, detection test paper according to claim 1 is characterized in that: have two row's lock liquid parts (15) on the base plate (11) and be sandwiched in one between two row's lock liquid parts (15) and arrange responding layer (12).
15, detection test paper according to claim 1 is characterized in that: have two strip lock liquid parts (15) that are arranged side by side on the base plate (11) and be sandwiched in one between two strip lock liquid parts (15) and arrange responding layer (12).
16, detection test paper according to claim 1 is characterized in that: have strip lock liquid parts (15) on the base plate (11), have a round on the strip lock liquid parts (15), be mounted with a responding layer (12) in each hole.
17, according to each described detection test paper of claim 1 to 16, it is characterized in that: upper and lower two all the respond layer (12) and the lock liquid parts (15) of base plate (11).
18, according to each described detection test paper of claim 1 to 16, the material that it is characterized in that responding layer and lock liquid parts is selected from possess hydrophilic property or did the material of hydrophilic treatment.
19, according to each described detection test paper of claim 4 to 6, the material that it is characterized in that the application of sample layer is selected from possess hydrophilic property or did the material of hydrophilic treatment.
20, detection test paper according to claim 7, the material that it is characterized in that the sample separation layer are selected from possess hydrophilic property or did the material of hydrophilic treatment.
Claims (10)
1. one kind is detected test paper, comprises base plate (11) and is positioned at responding layer (12) on the base plate, and it is characterized in that: at least one side in responding layer (12) includes the lock liquid parts (15) that are used to absorb unnecessary liquid.
2. detection test paper according to claim 1 is characterized in that: the speed that lock liquid parts (15) absorb liquid is less than or equal to the speed that responding layer (12) absorbs liquid.
3. detection test paper according to claim 1 is characterized in that: lock liquid parts (15) that are used to absorb unnecessary liquid are respectively arranged in the relative both sides of responding layer (12).
4. detection test paper according to claim 1 is characterized in that: detect test paper and also comprise the application of sample layer (13) that is positioned on the responding layer (12), application of sample layer (13) contacts side by side, overlaps mutually or do not contact mutually with lock liquid parts (15).
5. detection test paper according to claim 4 is characterized in that: contact side by side or overlap mutually between responding layer (12) and lock liquid parts (15).
6. detection test paper according to claim 4 is characterized in that: intercepted by the gap between responding layer (12) and the lock liquid parts (15) or intercepted by fluid-tight barrier blocks (18).
7. detection test paper according to claim 4 is characterized in that: also comprise at least one sample separation layer (19) between application of sample layer and the responding layer.
8. detection test paper according to claim 1 is characterized in that: lock liquid parts (15) have capillary channel (20) at an end of orientating reaction layer (12), and the material of described lock liquid parts (15) is a material impervious to water.
9. detection test paper according to claim 1 is characterized in that: responding layer (12) is surrounded by the lock liquid parts (15) more than three or three, and these lock liquid parts (15) are that the center is the regular polygon layout with responding layer (12).
10. detection test paper according to claim 1 is characterized in that: the size of lock liquid parts (15) is bigger than responding layer (12), and there is a hole inside, and responding layer (12) is enclosed in the hole of locking the liquid parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010542684XA CN102128918B (en) | 2010-11-11 | 2010-11-11 | Detecting test paper |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010542684XA CN102128918B (en) | 2010-11-11 | 2010-11-11 | Detecting test paper |
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| Publication Number | Publication Date |
|---|---|
| CN102128918A true CN102128918A (en) | 2011-07-20 |
| CN102128918B CN102128918B (en) | 2013-12-04 |
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|---|---|---|---|
| CN201010542684XA Active CN102128918B (en) | 2010-11-11 | 2010-11-11 | Detecting test paper |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102680672A (en) * | 2012-05-08 | 2012-09-19 | 艾康生物技术(杭州)有限公司 | Detection device |
| CN103267839A (en) * | 2013-04-28 | 2013-08-28 | 上海快灵生物科技有限公司 | Enclosed chromatographic test strip plastic card box |
| CN106645763A (en) * | 2017-01-03 | 2017-05-10 | 长沙中生众捷生物技术有限公司 | Total cholesterol detection reagent and total cholesterol detection paper |
| CN106645758A (en) * | 2017-01-03 | 2017-05-10 | 长沙中生众捷生物技术有限公司 | Detection reagent and test strip for creatinine |
| CN106706608A (en) * | 2017-01-03 | 2017-05-24 | 长沙中生众捷生物技术有限公司 | Detection reagent and test paper for beta-hydroxybutyrate |
| CN110220894A (en) * | 2019-06-27 | 2019-09-10 | 丰能医药科技（上海）有限责任公司 | A kind of household medicine detection paper handkerchief |
| CN110514820A (en) * | 2019-08-27 | 2019-11-29 | 黄连生 | A kind of portable urine test paper reducing interference |
| CN112305233A (en) * | 2019-07-23 | 2021-02-02 | 南方科技大学 | Automatic urine collection and detection method and urine detection controller |
| CN112673260A (en) * | 2019-09-10 | 2021-04-16 | 株式会社爱蓓儿 | Cartridge for measuring blood coagulation time and blood coagulation time measuring device |
| SE2050749A1 (en) * | 2020-06-24 | 2021-12-25 | Hemcheck Sweden Ab | Collection device for bodily fluid samples |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102680672A (en) * | 2012-05-08 | 2012-09-19 | 艾康生物技术(杭州)有限公司 | Detection device |
| CN102680672B (en) * | 2012-05-08 | 2015-02-11 | 艾康生物技术(杭州)有限公司 | Detection device |
| CN103267839A (en) * | 2013-04-28 | 2013-08-28 | 上海快灵生物科技有限公司 | Enclosed chromatographic test strip plastic card box |
| CN106645763A (en) * | 2017-01-03 | 2017-05-10 | 长沙中生众捷生物技术有限公司 | Total cholesterol detection reagent and total cholesterol detection paper |
| CN106645758A (en) * | 2017-01-03 | 2017-05-10 | 长沙中生众捷生物技术有限公司 | Detection reagent and test strip for creatinine |
| CN106706608A (en) * | 2017-01-03 | 2017-05-24 | 长沙中生众捷生物技术有限公司 | Detection reagent and test paper for beta-hydroxybutyrate |
| CN110220894A (en) * | 2019-06-27 | 2019-09-10 | 丰能医药科技（上海）有限责任公司 | A kind of household medicine detection paper handkerchief |
| CN110220894B (en) * | 2019-06-27 | 2021-10-08 | 丰能医药科技（上海）有限责任公司 | Domestic medical science detects paper handkerchief |
| CN112305233A (en) * | 2019-07-23 | 2021-02-02 | 南方科技大学 | Automatic urine collection and detection method and urine detection controller |
| CN110514820A (en) * | 2019-08-27 | 2019-11-29 | 黄连生 | A kind of portable urine test paper reducing interference |
| CN112673260A (en) * | 2019-09-10 | 2021-04-16 | 株式会社爱蓓儿 | Cartridge for measuring blood coagulation time and blood coagulation time measuring device |
| CN112673260B (en) * | 2019-09-10 | 2022-04-12 | 株式会社爱蓓儿 | Cartridge for measuring blood coagulation time and blood coagulation time measuring device |
| SE2050749A1 (en) * | 2020-06-24 | 2021-12-25 | Hemcheck Sweden Ab | Collection device for bodily fluid samples |
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