CN101979109A - Double-nasal cavity continuous nasal administration device and using method thereof - Google Patents
Double-nasal cavity continuous nasal administration device and using method thereof Download PDFInfo
- Publication number
- CN101979109A CN101979109A CN 201010521697 CN201010521697A CN101979109A CN 101979109 A CN101979109 A CN 101979109A CN 201010521697 CN201010521697 CN 201010521697 CN 201010521697 A CN201010521697 A CN 201010521697A CN 101979109 A CN101979109 A CN 101979109A
- Authority
- CN
- China
- Prior art keywords
- nasal cavity
- protective sleeve
- drug release
- release head
- nasal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention discloses a double-nasal cavity continuous nasal administration device and a using method thereof. The device comprises an osmotic pump (3), PE pipes (2), a medicament releasing head (1), a protective sleeve (4) and a tee pipe (5), wherein the osmotic pump (3) is communicated with two PE pipes (2) through the tee pipe (5); opposite ends of the two PE pipes (2) and the tee pipe (5) are communicated with one medicament releasing head (1) respectively; the medicament releasing head (1) is regular cone-shaped and a passage (6) in the medicament releasing head (1) is communicated with the PE pipes (2); the protective sleeve (4) is an independent body and is a regular frustum body corresponding to the medicament releasing head (1); the minimal inner diameter of the inner cavity passage (7) of the protective sleeve (4) is slightly greater than the maximal outer diameter of the medicament releasing head (1), so that the medicament releasing head (1) can conveniently slide in the inner cavity passage (7); and the protective sleeve (4) is used for sealing the inferior nasal meatus of the nasal cavity of a human body. The device can realize continuous administration and double-nasal cavity administration and prevents a medicament releaser from entering the oropharynx. The using method is simple and convenient.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of pair of nasal cavity and continue nose administration device and using method thereof.
Background technology
Because the existence of blood brain barrier etc., medicine can not effectively arrive the central nervous system through peripherally administered (oral, vein etc.); Though the tricorn administration can directly enter the central nervous system,, be subjected to very big restriction in clinical practice because it is traumatic.As the nasal cavity structure chart of Fig. 1, nose administration can be walked around the medication of blood brain barrier by the nervi olfactory 1 direct central nervous system 4 of arrival of last nasal cavity 3, has noninvasive characteristics simultaneously, thereby is a kind of extensive potential applicability in clinical practice that has.
Yet traditional nose administration method has very big deficiency at present, has limited its application in clinical.Traditional nasal drip also is classic methods, and its defective is: (1) requires the patient to have special position, as Meccah position, makes the wish of patient's partner treatment reduce, and is difficult to especially carry out for the treatment of comatose patient; (2) be difficult to effectively arrive the top of nasal cavity, the drug absorption rate is lower, and the medicine less than about 1% can enter the central nervous system, wastes bigger; (3) blood vessel that most of medicine via intranasal application is abundant absorbs and enters into peripheral circulation, thereby has the possibility that produces potential side effect; (4) drip 100 μ l medicine major parts along with respiratory air flow enters upper respiratory tract, the patient who disappears for swallowing reflex has the possibility of upper respiratory tract obstruction at every turn; (5) can only alternately give a nostril, administration simultaneously, (6) can not continue medication, and general administration time can only continue 20-30min.
The tubule nasal drip, this method is used superfine PE pipe, after connecting syringe medicine is directly sent into the nasal cavity top, effectively improve traditional nasal drip and can not effectively pass through the defective of nasal cavity lobe, but the defective that this method has is: (1) is easy to enter by inferior nasal meatus 3 pharyngeal as the superfine pipe of Fig. 1, and particularly the patient of pharyngeal reflex disappearance is relatively more dangerous; In case and PE pipe mistake enters inferior nasal meatus 3 administrations, medicine is breathed out or enter pulmonary, the blood vessel that perhaps most of medicine via intranasal application is abundant absorbs and enters into peripheral circulation, not only can not reach therapeutic effect, also can have the possibility that produces potential side effect; (2) superfine PE and nasal cavity are misfitted, to the nasal cavity effect; (3) syringe injects a large amount of medicines at every turn, and high amount of drug can not enter maincenter by tractus olfactorius, but enters upper respiratory tract; (4) can only replace administration, administration simultaneously, (5) can not continue medication.
Nasal spray, this utilizes the mechanical spraying principle, about 100 μ l medicines are once sprayed, can effectively enter the nasal cavity top, this method has also been avoided the relatively poor shortcoming of tubule dose regimen toleration in addition, but it still has suitable defective: (1) each medicine that injects, and high amount of drug can not enter maincenter by tractus olfactorius, enter upper respiratory tract, efficient is lower; (2) can only replace administration, administration simultaneously, (3) can not continue medication.
Summary of the invention
The object of the present invention is to provide a kind of pair of nasal cavity to continue the nose administration device.
Another object of the present invention is to provide a kind of pair of nasal cavity to continue the using method of nose administration device.
Purpose of the present invention can be achieved through the following technical solutions:
A kind of pair of nasal cavity continues the nose administration device, comprise osmotic pumps, PE pipe, drug release head, protective sleeve and tee T, described osmotic pumps is communicated with by tee T and two PE pipes, described two PE pipe, its end relative with tee T is communicated with a drug release head respectively, described drug release head is positive taper, and has a passage to communicate with the PE pipe in this drug release head; Described protective sleeve is a separate component; and be and the corresponding positive cone table of drug release head; the minimum diameter of its bore passages is slightly larger than the maximum outside diameter of drug release head, is convenient to the drug release head and slides in the passage of chamber within it, and described protective sleeve is used to seal the inferior nasal meatus of human body nasal cavity.
Above-mentioned two nasal cavities continue the nose administration device, and it is that described protective sleeve bore passages can be for cylindrical.
Above-mentioned two nasal cavities continue the nose administration device, and it is that the passage of described drug release head and PE manage a corresponding end and be funnel-form, can enlarge the contact area of medicine and last nasal cavity, improves the effective absorbance of medicine.
The positive taper tip designs of drug release head is smooth arc, can avoid damage or stimulate nasal cavity.
A kind of pair of nasal cavity continues the using method of nose administration device; earlier protective sleeve is placed a side nasal cavity; the drug release head enters upward nasal cavity of nasal cavity arrival by the bore passages of protective sleeve; the protective sleeve of dropping back then; according to inserting another protective sleeve with quadrat method in the opposite side nasal cavity, another drug release head enters upward nasal cavity of opposite side nasal cavity arrival, the protective sleeve of dropping back then by the passage of protective sleeve; adjust the osmotic pumps transporting velocity, administration.
Beneficial effect of the present invention:
1, adopts osmotic pumps as continuing conveyer device, can regulate drug conveying amount and drug conveying speed, and can quantitatively continue medication two weeks.
2, the shaped design of drug release head and last nasal cavity structure match, not only can avoid the stimulation of nasal cavity but also can make the drug release head to greatest extent near the nervi olfactory administration, medicine is concentrated on the nervi olfactory, rather than be dispersed in the nasal cavity, both can improve the effective rate of utilization of medicine, the influence that the administration process is not breathed is again breathed out medicine or the suction trachea when avoiding breathing, thereby realizes two nasal-cavity administrations.
3, by protective sleeve the drug release head is arrived smoothly and go up the nasal cavity tram; it is pharyngeal to prevent that the drug release head from entering by inferior nasal meatus; to such an extent as to or prevent that drug release head mistake from entering the abundant blood vessel absorption of the most of medicine via intranasal application of inferior nasal meatus administration and entering into peripheral circulation; not only can not reach therapeutic effect, also can have the possibility that produces potential side effect.
Description of drawings
Fig. 1 nasal cavity structure chart.
Wherein: 1-nervi olfactory, 2-inferior nasal meatus 3-last nasal cavity 4-nervus centralis
The two nasal cavities of Fig. 2 continue nose administration device part section structural representation.
The longitudinal sectional drawing of the preferred version of Fig. 3 drug release head.
The specific embodiment
As Fig. 2 is the part section structural representation that two nasal cavities continue the nose administration device, comprise osmotic pumps 3, PE pipe 2, drug release head 1, protective sleeve 4 and tee T 5, osmotic pumps 3 is communicated with by tee T 5 and two PE pipes 2, two PE pipe 2 and tee T 5 relative ends are communicated with a drug release head 1 respectively, drug release head 1 is positive taper, and has a passage 6 to communicate with PE pipe 2 in this drug release head 1; Protective sleeve 4 is a separate component; and be and drug release head 1 corresponding positive cone table; the minimum diameter of its bore passages 7 is slightly larger than the maximum outside diameter of drug release head 1, is convenient to drug release head 1 and slides in the chamber passage 7 within it, and protective sleeve 4 is used to seal the inferior nasal meatus of human body nasal cavity.As a kind of preferred version, bore passages 7 is cylindric, and its slightly larger in diameter is in the maximum outside diameter of drug release head 1, and the positive taper tip designs of drug release head 1 is smooth arc, can avoid damage or stimulate nasal cavity.
As a kind of preferred version, passage 6 is managed the 5 corresponding other ends with PE and is funnel-form as Fig. 3, and this structure can enlarge the medicine and the contact area of last nasal cavity that oozes out in the passage 6, the effective absorbance of raising medicine.
During use; earlier protective sleeve 4 is placed a side nasal cavity; drug release head 1 enters upward nasal cavity of nasal cavity arrival by the bore passages 7 of protective sleeve 4; the protective sleeve 4 of dropping back then; according in the opposite side nasal cavity, inserting another protective sleeve 4 with quadrat method; another drug release head 1 enters upward nasal cavity of opposite side nasal cavity arrival by the passage 7 of protective sleeve 4; the protective sleeve 4 of dropping back then; adjust the transporting velocity of osmotic pumps as required; protect the ALZET Osmotic pumps that osmotic pumps is produced for ALZET company, this pump can be regulated the speed of conveying, and sustainable two weeks; enter clinical use for many years, performance is comparatively stable.When protective sleeve 4 is inserted nasal cavity; drug release head 1 and the inferior nasal meatus in the nasal cavity can be kept apart; it is pharyngeal to avoid drug release head 1 to have inferior nasal meatus to enter; to such an extent as to or avoid drug release head 1 mistake to enter the abundant blood vessel of the most of medicine via intranasal application of inferior nasal meatus administration absorbing and enter into peripheral circulation; not only can not reach therapeutic effect, also can have the possibility that produces potential side effect, drug release head 1 enters nasal cavity smoothly and arrives when going up nasal cavity; recession protective sleeve 4 keeps breathing unobstructed.
Protective sleeve 4 and drug release head 1 can adopt conventional medical grade rubber material smooth, that intensity is high slightly to make.
Claims (4)
1. two nasal cavities continue the nose administration device, comprise that osmotic pumps (3), PE manage (2), drug release head (1), protective sleeve (4) and tee T (5), described osmotic pumps (3) is communicated with by tee T (5) and two PE pipes (2), described two PE pipes (2), its end relative with tee T (5) is communicated with a drug release head (1) respectively, it is characterized in that described drug release head (1) is positive taper, and in this drug release head (1), have a passage (6) to communicate with PE pipe (2); Described protective sleeve (4) is a separate component; and be and the corresponding positive cone table of drug release head (1); the minimum diameter of its bore passages (7) is slightly larger than the maximum outside diameter of drug release head (1); be convenient to drug release head (1) and slide in the chamber passage (7) within it, described protective sleeve (4) is used to seal the inferior nasal meatus of human body nasal cavity.
2. pair nasal cavity according to claim 1 continues the nose administration device, it is characterized in that described protective sleeve (4) bore passages (7) is for cylindrical.
3. pair nasal cavity according to claim 1 continues the nose administration device, it is characterized in that described passage (6) and PE pipe (2) corresponding end are funnel-form.
4. described pair of nasal cavity of claim 1 continues the using method of nose administration device; it is characterized in that earlier protective sleeve 4 being placed a side nasal cavity; drug release head 1 enters upward nasal cavity of nasal cavity arrival by the bore passages 7 of protective sleeve 4; the protective sleeve 4 of dropping back then; according to inserting another protective sleeve 4 with quadrat method in the opposite side nasal cavity, another drug release head 1 enters upward nasal cavity of opposite side nasal cavity arrival, the protective sleeve 4 of dropping back then by the passage 7 of protective sleeve 4; adjust the osmotic pumps transporting velocity, administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105216979A CN101979109B (en) | 2010-10-27 | 2010-10-27 | Double-nasal cavity continuous nasal administration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105216979A CN101979109B (en) | 2010-10-27 | 2010-10-27 | Double-nasal cavity continuous nasal administration device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101979109A true CN101979109A (en) | 2011-02-23 |
| CN101979109B CN101979109B (en) | 2012-05-23 |
Family
ID=43599664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105216979A Expired - Fee Related CN101979109B (en) | 2010-10-27 | 2010-10-27 | Double-nasal cavity continuous nasal administration device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101979109B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247642A (en) * | 2011-04-26 | 2011-11-23 | 上海白塔医药科技有限公司 | Portable continuous intranasal administration device |
| CN115282411A (en) * | 2022-01-14 | 2022-11-04 | 温州医科大学 | Delivery system for delivering drugs into the brain using the nasal olfactory region and method of use thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6679265B2 (en) * | 2001-10-25 | 2004-01-20 | Worldwide Medical Technologies | Nasal cannula |
| CN2882564Y (en) * | 2005-07-25 | 2007-03-28 | 李范珠 | Nasal medicine feeder for rodent |
| CN201275343Y (en) * | 2008-11-01 | 2009-07-22 | 王铖 | Administration device for nasal mucous membrane |
| US20090187098A1 (en) * | 2004-04-21 | 2009-07-23 | Acclarent, Inc. | Devices, Systems and Methods for Diagnosing and Treating Sinusitis and Other Disorders of the Ears, Nose, and/or Throat |
| CN201949493U (en) * | 2010-10-27 | 2011-08-31 | 刘新峰 | Continuous intranasal medicine application device for double nasal cavities |
-
2010
- 2010-10-27 CN CN2010105216979A patent/CN101979109B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6679265B2 (en) * | 2001-10-25 | 2004-01-20 | Worldwide Medical Technologies | Nasal cannula |
| US20090187098A1 (en) * | 2004-04-21 | 2009-07-23 | Acclarent, Inc. | Devices, Systems and Methods for Diagnosing and Treating Sinusitis and Other Disorders of the Ears, Nose, and/or Throat |
| CN2882564Y (en) * | 2005-07-25 | 2007-03-28 | 李范珠 | Nasal medicine feeder for rodent |
| CN201275343Y (en) * | 2008-11-01 | 2009-07-22 | 王铖 | Administration device for nasal mucous membrane |
| CN201949493U (en) * | 2010-10-27 | 2011-08-31 | 刘新峰 | Continuous intranasal medicine application device for double nasal cavities |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247642A (en) * | 2011-04-26 | 2011-11-23 | 上海白塔医药科技有限公司 | Portable continuous intranasal administration device |
| CN102247642B (en) * | 2011-04-26 | 2013-10-16 | 上海白塔医药科技有限公司 | Portable continuous intranasal administration device |
| CN115282411A (en) * | 2022-01-14 | 2022-11-04 | 温州医科大学 | Delivery system for delivering drugs into the brain using the nasal olfactory region and method of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101979109B (en) | 2012-05-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN203107937U (en) | Medical treatment medicine delivering cover for respiration internal medicine | |
| CN205832327U (en) | Children atomizing mask | |
| CN201949493U (en) | Continuous intranasal medicine application device for double nasal cavities | |
| CN106730188A (en) | A kind of Respiratory Medicine is atomized chemical spraying device | |
| CN210472732U (en) | Medicine device is spouted with internal medicine to tuberculosis prevention and cure | |
| CN101979109B (en) | Double-nasal cavity continuous nasal administration device | |
| CN204092782U (en) | A kind of medical vaporizer | |
| CN108543172A (en) | A kind of respiratory tract positioning spray delivery device | |
| CN204767005U (en) | Uropoiesis and reproductive system ware of dosing | |
| CN105307713A (en) | Element for inhaling medicinal substances | |
| CN203816006U (en) | Medicament sprayer for use in respiratory medicine | |
| CN105413028A (en) | Drug delivery device for respiratory surgery | |
| CN107551361A (en) | A kind of atomizing face mask | |
| CN211068510U (en) | Department of respiration is with device of dosing | |
| CN203852680U (en) | Medical atomizing sprayer | |
| CN209316725U (en) | A kind of Respiratory Medicine clinic suction type medicator | |
| CN202982902U (en) | Plaster-type oral cavity esophagus drug dressing treatment structure | |
| CN202822371U (en) | Atomizer disposable sprayer | |
| CN205041926U (en) | Face guard of breathing in atomizes | |
| CN103272316A (en) | Respiratory tract dual-naris dosing device | |
| CN205867296U (en) | Paediatrics nursing is with throat's ware of dosing | |
| CN203647823U (en) | Drug delivery device for pneumology department | |
| CN213642612U (en) | Medicine sprayer for respiratory medicine | |
| CN203355061U (en) | Multifunctional pneumatic atomization drug delivery device | |
| CN208943173U (en) | A kind of atomization oxygen face mask facilitating mouth containing good airproof performance |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120523 Termination date: 20141027 |
|
| EXPY | Termination of patent right or utility model |