CN101896204B - 用于治疗紫癜的组合物及方法 - Google Patents
用于治疗紫癜的组合物及方法 Download PDFInfo
- Publication number
- CN101896204B CN101896204B CN200880116406.9A CN200880116406A CN101896204B CN 101896204 B CN101896204 B CN 101896204B CN 200880116406 A CN200880116406 A CN 200880116406A CN 101896204 B CN101896204 B CN 101896204B
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- China
- Prior art keywords
- adrenergic receptor
- receptor agonists
- apply
- given
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Abstract
Description
第…天 | 紫癜面积(cm2) | 效果 | 注释 |
0 | 3.67 | - | 基线 |
7 | 1.48 | 从基线↓60% | |
14 | 0.35 | 从基线↓90% | |
24 | 5.72 | 从基线↑34% | 园艺工作后注意到紫癜↑ |
36 | 2.52 | 从基线↓31% |
第…天 | 紫癜面积(cm2) | 效果 | 注释 |
0 | 8.94 | - | 基线 |
17 | 9.95 | 从基线↑11% | |
29 | 5.73 | 从基线↓36% | |
44 | 5.6 | 从基线↓37% | |
81 | 1.44 | 从基线↓84% | |
91 | 0.42 | 从基线↓95% | 药物在第91天中断 |
98 | 1.96 | 从基线↑366% | 停药治疗后第7天 |
112 | 0.46 | 从基线↑10% | 停药治疗后第14天 |
122 | 2.22 | 从基线↑428% | 停药治疗后第24天 |
第…天 | 紫癜面积(cm2) | 效果 | 注释 |
0 | 1.72 | - | 基线 |
7 | 0.00 | 从基线↓100% | |
31 | 0.00 | 从基线↓100% | |
36 | 0.36 | 从基线↓79% |
Claims (25)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98856407P | 2007-11-16 | 2007-11-16 | |
US60/988,564 | 2007-11-16 | ||
PCT/US2008/083774 WO2009065116A1 (en) | 2007-11-16 | 2008-11-17 | Compositions and methods for treating purpura |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101896204A CN101896204A (zh) | 2010-11-24 |
CN101896204B true CN101896204B (zh) | 2015-05-20 |
Family
ID=40639204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880116406.9A Active CN101896204B (zh) | 2007-11-16 | 2008-11-17 | 用于治疗紫癜的组合物及方法 |
Country Status (19)
Country | Link |
---|---|
US (4) | US8114898B2 (zh) |
EP (3) | EP3498299A1 (zh) |
JP (2) | JP5670196B2 (zh) |
KR (1) | KR101577471B1 (zh) |
CN (1) | CN101896204B (zh) |
AU (1) | AU2008322411C1 (zh) |
BR (1) | BRPI0819075A2 (zh) |
CA (1) | CA2703109C (zh) |
DK (1) | DK2818184T3 (zh) |
ES (1) | ES2709120T3 (zh) |
HR (1) | HRP20190214T1 (zh) |
HU (1) | HUE042931T2 (zh) |
IL (1) | IL205704A (zh) |
MX (1) | MX2010005331A (zh) |
PL (1) | PL2818184T3 (zh) |
PT (1) | PT2818184T (zh) |
SI (1) | SI2818184T1 (zh) |
TR (1) | TR201901431T4 (zh) |
WO (1) | WO2009065116A1 (zh) |
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