CN101598685A - 对样品的至少一部分成像的装置和方法 - Google Patents
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- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/02—Interferometers
- G01B9/02034—Interferometers characterised by particularly shaped beams or wavefronts
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Abstract
一种用于执行样品的低相干性测距的设备,该样品具有高横向分辨率和大的焦深,该装置包括光学测距系统,该系统包括光源、用于将光从光源引导到样品的装置,将反射光从样品引导到检测器的装置,至少一个检测器,用于处理由检测器接收的光数据并产生图像的装置;并且光学元件具有小于或等于5μm的横向分辨率Δris,和至少约50μm的焦深Δz。
Description
本申请是申请号为03805597.X,国际申请号为PCT/US03/00699的发明专利申请的分案申请。
原案申请日:2003年1月10日。
原案发明名称:用于具有可提高分辨率和景深的轴线焦点的OCT成像的装置。
发明人:
GUILLERMO J.TEARNEY
BREET E.BOUMA
互相参考的相关申请
本申请要求2002年1月11日申请的共同未决的美国临时申请No.60/347582的优先权,在此结合本申请的全部内容作为参考。
发明领域
本发明涉及使用光学相干X线体层照相术用于成像组织样本,并结合光学元件来改善横向分辨率和焦深的装置。
目前,光学相干X线体层照相术(OCT)的使用只限于显现生物组织内部的体系形态结构。具有OCT的亚细胞特征的图像没有被很好的论证,因为相对差的横向分辨率需要保持焦深。执行高横向分辨率、大的景深截面OCT图像的能力将允许应用于上皮癌的较早诊断,以及其他需要亚细胞级分辨率的生物医学成像诊断。
到今天,还没有已知的光学相干X线体层照相术结构能在大的景深上执行高横向分辨率成像。人们将期待有一种简单的设备来执行高横向分辨率,大景深光学相干X线体层照相术。另外,由于允许通过单个光纤传送光,该设备也能容易的结合到导管或内诊镜中。这些特性将使得该设备能制造用于执行光学相干X线体层照相术的应用,该应用需要在生物系统内的远地的亚细胞分辨率成像。
发明内容
本发明的一个方面,是提供一种对样品的至少一部分成像的装置,包括:提供电磁辐射的第一干涉测量(inferometric)装置;和配置以接收电磁辐射的第二装置,并配置以产生合成电磁强度分布,其中,沿着特定方向,对于至少预定距离该强度分布近似为常数。
其中第二装置是光学装置,该装置被配置成光学成像的样品,如旋转三棱镜、折射光学元件或环。
第二装置还包括衍射元件和透镜的组合、变迹透镜、全息图和衍射元件的组合。
其中强度分布是贝赛尔射束。
该装置还包括适合与第二装置结合的第三装置,以便转换强度分布和样品中的至少一个。
其中对强度分布和样品中的至少一个进行转换以产生具有2维或更多维的图像。
其中强度分布半幅值全宽小于10μm。
其中预定距离至少是50μm。
其中强度分布的至少一部分包括非高斯分布。
该装置还包括配置的第四装置以接收与强度分布有关的消息,并基于接收的消息显示图像。
本发明的另一方面,是提供一种对至少一部分样品进行成像的装置,包括:提供电磁辐射的第一干涉测量装置;和配置以接收电磁辐射的第二装置,并配置以产生合成电磁强度分布,其中,沿着特定方向,强度分布的至少两分区的宽度近似相同。
其中特定方向近似为垂直方向。
其中第二装置包括多个透镜。
其中一个分区至少部分的位于另一分区之上。
其中强度分布半幅值全宽小于10μm。
其中强度分布的至少一部分包括非高斯分布。
该装置还包括适合与第二装置结合的第三装置,以便转换强度分布和样品中的至少一个。
其中对强度分布和样品中的至少一个进行转换以产生具有2维或更多维的图像。
本发明的另一方面是,提供一种对样品的至少一部分成像的方法,包括:a)使用干涉测量装置提供电磁辐射;b)接收电磁辐射并产生合成电磁强度分布,其中,沿着特定方向,对于至少预定距离该强度分布近似为常数。
其中利用光学装置执行步骤(b),该装置被配置成光学成像样品。
其中使用旋转三棱透镜执行步骤(b)。
其中使用折射光学元件执行步骤(b)。
其中使用环执行步骤(b)。
其中使用衍射元件和透镜的组合来执行步骤(b)。
其中使用变迹透镜、全息图和衍射元件的组合执行步骤(b)。
其中强度分布是贝赛尔射束。
该方法还包括对强度分布和样品中的至少一个进行转换。
其中对强度分布和样品中的至少一个进行转换以产生具有2维或更多维的图像。
其中强度分布半幅值全宽小于10μm。
其中预定距离至少是50μm。
其中强度分布的至少一部分包括非高斯分布。
该方法还包括接收与强度分布有关的消息的步骤,并基于接收的消息显示图像。
本发明的另一方面是,提供一种对样品的至少一部分成像的方法,包括:a)使用干涉测量装置提供电磁辐射;和b)接收电磁辐射,并产生合成电磁强度分布,其中,沿着特定方向,强度分布的至少两部分的宽度近似相同。
其中利用光学装置执行步骤(b),该装置被配置成光学成像该样品。
其中使用旋转三棱透镜执行步骤(b)。
其中使用折射光学元件执行步骤(b)。
其中使用环执行步骤(b)。
该方法,使用衍射元件和透镜的组合来执行步骤(b)。
其中使用变迹透镜、全息图和衍射元件的组合执行步骤(b)。
其中强度分布是贝赛尔射束。
该方法还包括对强度分布和样品中的至少一个进行转换。
其中对强度分布和样品中的至少一个进行转换以产生具有2维或更多维的图像。
其中强度分布半幅值全宽小于10μm。
其中预定距离至少是50μm。
其中强度分布的至少一部分包括非高斯分布。
该方法还包括接收与强度分布有关的消息的步骤,并基于接收的消息显示图像。
本发明的另一个方面,是提供一种用于对具有高横向分辨率和大焦深的样品执行低相干测距的装置,包括:
a.一个光学测距系统,包括:
i)光源,
ii)用于将来自所述光源的光引导到所述样品的装置,
iii)用于将来自所述样品的反射光引导到检测器的装置,
iv)至少一个检测器,
v)用于处理由所述检测器接收的光数据并产生图像的装置;
和
b.一个光学元件,具有
i)定义为Δris小于或等于5μm的横向分辨率,和
ii)至少50μm的焦深Δz。
其中所述光源是宽谱光源、脉冲激光器或连续波激光器。
其中用于引导光到所述样品和引导来自所述样品的光的所述装置是干涉仪、光学波导透镜或光纤透镜。
其中所述检测器是单检测器或检测器阵。
所述处理器能够分析干涉测量的数据、分析临时检测或分析光谱分析。
其中所述光学元件是锥透镜元件、是能透射、发射或折射的。
所述光学元件是变迹透镜或全息图。
所述光学元件是衍射元件和透镜的组合体。
所述光学元件是变迹透镜、全息图和衍射元件的组合体。
本发明的另一个方面是提供一种用于对具有高横向分辨率和大焦深的样品执行低相干测距的装置,包括:
a.一个光学测距系统,包括:
i)光源,
ii)用于将来自所述光源的光引导到所述样品的装置,
iii)用于将来自所述样品的反射光引导到检测器的装置,
iv)检测器;
b.用于处理由所述检测器接收的光数据并产生图像的装置;和
c.产生在深度上分布的多个焦斑的光学元件。
其中所述多个焦斑在直的垂直线中。
其中所述多个焦斑相对于所述垂直平面具有一个角度。
其中所述多个焦斑具有不同的纵向位置。
其中所述光学元件是锥透镜元件。
其中所述光学元件是能透射的。
其中所述光学元件是能发射的。
其中所述光学元件是能折射的。
其中所述光学元件是变迹透镜。
其中所述光学元件是全息图。
其中所述光学元件是衍射元件和透镜的组合体。
其中所述光学元件是变迹透镜、全息图和衍射元件的组合体。
该装置还包括用于产生多个物斑的装置,以便每个斑点从它的起点到光学元件具有唯一距离,以便每个斑点的图像具有唯一纵向位置。
其中所述多个斑点产生装置包括多个光纤。
其中所述多个斑点产生装置包括多孔障板。
其中所述多个斑点产生装置包括衍射光栅。
其中所述多个斑点产生装置包括微透镜阵列。
该装置还包括扫描装置,该扫描装置引导光到样品上和引导来自样品的光。
该装置还包括用于扫描所述光的装置。
其中所述扫描装置是扫描镜。
其中所述扫描装置是用于相对于所述光学元件移动光纤的装置。
其中所述扫描装置是用于移动所述光纤和光学元件的装置。
其中所述扫描装置是用于移动由所述光纤发出的光束的装置。
其中所述扫描装置是用于改变光束相对于光学元件的角度的装置。
该装置还包括用于密封所述装置的外壳。
该装置还包括用于扫描所述轴向焦点的装置。
本发明的另一方面是提供一种获得样品的高分辨率和高焦深的方法,包括:
a.提供光源;
b.通过光引导装置将来自所述光源的光通过光学元件引导到样品上;
c.接收来自样品返回通过所述光学元件的反射光;
d.将所述反射光引导到检测器;和
e.处理来自检测器的数据以产生图像,
其中所述光学元件具有小于5μm的横向分辨率和大于50μm的焦深。
附图概述
本发明如附图中所示,其中相同的参考符号指定所有附图中相同或相似的部分;
图1描述了使用折射旋转三棱镜聚焦。并行光束,从左入射,在具有窄的宽度和大的深度的轴线上聚焦。
图2描述了在样本支架中具有旋转三棱镜光学部件的OCT系统视图。
图3描述了在轴向位置和照明环之间的关系的示意图。
图4A是图像形成的示意图。
图4B是在Y轴方向中整个光学系统的变换示意图。
图4C是整个光学系统的旋转示意图。
图4D是在X-Y平面内轴线焦点的角偏转示意图。
图5是用于在高景深下执行高横向分辨率测距的系统示意图。
图6是偏移光纤阵列的示意图。
图7是光纤阵列、微透镜阵列和衍射光栅的示意图。
图8是变迹光瞳平面滤波器的实施例示意图。
图9是使用在成像透镜前面的变迹器的示意图。
优选实施例的详细描述
定义
“旋转三棱镜”应当指能够产生轴线焦点的任何光学元件(或其组合)。折射、衍射,和反射旋转三棱镜已经被演示,见J.H.McLeod,J.Opt.Soc.Am44,592(1954);J.H.McLeod,J.Opt.Soc.Am50,166(1960);和J.Opt.Soc.Am48,576(1958).
“焦深“应当指纵向距离,在该距离上光束直径增加系数ζ(典型的ζ=sqrt(2)或2)。对于高斯光束,该sqt(2)焦深是
对于d=5μm的典型高斯光点直径(1/e2直径),以及830nm的波长,该焦深大约是48μm。用于均匀光束的焦深(3dB半幅值全宽强度响应移动通过纵向平面的平面反射器)可定义为:
对于NA=0.2,其产生5μm的光点直径,在830nm时用于均匀光束的焦深大约是17μm。
“纵向”应当指实质上平行于光轴。
“纵向分辨率”应当指两个点可以分开的纵向上的最大距离Δz,并且仍然能被光学检测装置区分开。
“光点直径”应当指聚焦光点的横向直径。对于高斯光束,该光点直径被定义为光点的横向宽度,该焦点的亮度减去系数1/e2。对于平行高斯光束,该光点直径被定义为
其中D是透镜中的光束直径,f是透镜的焦点长度,以及λ是波长。对于平顶或均匀光束,该光点半径被定义为Airy磁盘的第一零点的横向长度,
其中
并且n是浸没媒质的折射指数。
“横向”应当指实质上垂直于光轴。
“横向分辨率”应当指两个点可以分开的横向上的最小距离Δr,并且仍然能被光学检测装置区别开。一种普遍使用的横向分辨率大约是Δr=d(用于高斯光束)或Δr=W(用于均匀光束)。
基本原理
产生具有窄的横向光束直径和大的长度(或焦深)的轴线焦点。结合OCT使用,该线状焦点的直径确定横向分辨率并且该长度确定景深。在标准OCT中,利用麦尔逊干涉仪来执行来自沿着轴向焦点的点上的光背射的检测。当光源具有有限的光谱宽度时,该结构可用于确定背射点的轴向位置。通过光源的相干长度来确定该轴向分辨率。
本领域技术人员将明白存在各种公知设备用于产生线焦点。对于本领域技术人员来说,对于此,旋转三棱镜(折射、透射,或衍射光学元件(“DOE”))是一种可接受模型,并该方法将用于本发明来论证使用具有轴线较点的OCT来实现在大景深上的高分辨率成像。应当理解,该方法是示意性的并且不打算作为排除的模型。其他公知模型包括,但不限于,多焦点透镜,诸如Rayleigh-Wood透镜(OpticalProcesing and Computing,H.H Arsenault,T.Szoplik,andB.Macukow eds.,Academic Press Inc.,San Diego,CA,1989),使用色差以产生沿着纵向轴的依靠聚焦的波长阵列,等等。
分辨率
下面的部分讨论了如图1所示的使用折射的典型旋转三棱镜的物理原理。通过折射旋转三棱镜传输的光的强度分布(见R.Arioto,C.Saloma,T.Tanaka,and S.Kawata,APPL.Opt.31,6653(1992))由公式(1)给出:
其中E2(R)是入射在旋转三棱镜上的光的强度,并作为半径R,λ的函数,该半径是光的波长,并且β是通过旋转三棱镜的光的半角。与β有关的锥角α和焦深zD由公式(2a)和(2b)表示:
nSin(α)=Sin(α+β),(2a)
zD=R(Cot(β)-Tan(α)),(2b)
其中n是旋转三棱镜的折射系数。上述等式可用以确定轴线焦点的直径。对于平面波照明,该焦点直径由公式(3)给出:
在折射或衍射旋转三棱镜的情况下,等式(1)被修改,但在所有情况中,轴向焦点的直径确定成像系统的横向分辨率。本发明的主题是通过变化标准聚焦几何学来改善当前OCT系统典型的较差横向分辨率,在该几何学中焦点量(功率分布)被限制在横向和轴向尺寸中,该焦量中的一个只限制在横向上。
通过组合具有OCT的旋转三棱镜的高的横向局部(和弱的轴向局部),可以实现在大的视野之上提供高的三维局部的成像系统。通过光源的相干长度可独自确定关于该图像技术的轴向分辨率(OE.S.Swanson,D.Huang,M.R.Hee,J.G.Fujimoto,C.P.Lin,和C.A.Puliafito,Opt.Lett.17,151(1992))并通过公式(4)给出:
其中Δλ是光源的光谱宽度(半幅值全宽(“FWHM”))。
在优选实施例中,光学元件具有在大约0.5μm到10μm,尤其是小于或等于5μm范围内被定义为Δr=d0的横向分辨率。该光学元件最好在至少大约50μm具有Δz=zD。
成像
图4A描述了本发明一个实施例的完整OCT/旋转三棱镜系统。除了旋转三棱镜探针,所有部件对于OCT是标准部件。使用OCT来确定背射,提供了空间光栅扫描,该背射作为沿着轴线焦点的距离的函数。这典型的通过扫描干涉仪基准臂的长度来实现。旋转三棱镜具有这样的属性,即每个焦点的轴向位置对应三棱镜入射孔上唯一的环(见图3)。这种关系将允许通过扫描三棱镜孔上的照明环来代替扫描基准臂长度。
不管如何扫描轴向尺寸,为获得图像,必须执行对其他轴的扫描。通常以缓慢速率执行第二扫描尺寸。实现副轴慢扫描的方法包括在y方向上移动光学样品支架,包括光纤、准直透镜和旋转三棱镜(见图4B),绕着光纤轴旋转整个探针(见图4C),或在x-y平面上有角度的偏转线焦点(见图4D)。见,(G,J.Tearney,S.A.Boppart,B.E.Bouma,M.E.Brezinski,Opt.Lett.22,1618(1997))。通过使用压电转换器或机械或气动传动器,沿着y或z轴的线性移动以及旋转很容易在小型探针中实现。
图5是用于执行具有高景深的高横向分辨率测距的替代装置的示意图。该系统包括光源、光束重定向元件、检测器、和光学元件。该光学元件提供线焦点和样品上的焦斑阵列。
图6显示了偏移光纤阵列,该光纤阵列通过物镜被镜子定向,并用于取代样品上的纵向和横向尺寸中的焦(成像)斑。扫描该斑点(通过水平线和箭头指示该扫描方向)以产生多维图像。
图7示意了用于取代样品上的纵向和横向尺寸中的焦(成像)斑的光纤阵列、微透镜阵列和衍射光栅(镜子阵列)的示意图。来自光源(未示出)的光通过阵列中的光纤,并通过微透镜阵列到衍射光栅。通过光栅将光引导通过物镜并聚焦在样品上。扫描该斑点(由水平线和箭头指示该扫描方向)以产生多维图像。
一种用于在大的焦深上提供高横向分辨率的替换装置是在成像透镜的背面使用滤波器。该技术,通常称为变迹法,允许在旋转三棱镜中产生线焦点或产生沿着纵向尺寸定位的许多焦斑。使用环形变迹法形成射束焦点,先前已经描述在文献中(M,.MARTINEZ-Corral,P.Andres,J.Ojeda-Castaneda,G.Saavedra,Opt.Comm.119,491(1955))。然而,使用变迹法以产生在大的焦距上的高横向分辨率,其中以前没有描述由OCT进一步分析纵向数据。
图8显示了变迹光瞳平面滤波器的实施例。
图9显示了在成像透镜前面使用变迹器,其输出被聚焦在轴线上的示意图。
成像方法
本发明也提供一种获得样品的高分辨率和高焦深的方法,包括:
a.提供光源;
b.通过光引导装置将来自所述光源的光通过光学元件引导到样品上,该光学元件具有小于约5μm的横向分辨率和大于50μm的焦深;
c.接收来自样品返回通过所述光学元件的反射光;
d.引导所述反射光到检测器;和
e.处理来自检测器的数据产生图像
本发明的优点是OCT成像装置能沿着样品的横向和纵向尺寸进行亚细胞分辨率成像,该样品在小型,基于光纤的组件中。其他优点包括潜在的小规模和低成本的轴线焦点光学元件,诸如组合旋转三棱镜的变迹透镜。
尽管上面只详细描述了本发明很少的典型实施例,但本领域技术人员明白在本质上不脱离本发明的新技术和优点的情况下,对典型实施例的任何修改是可能的。因此,包含在本发明范围内的所有修改都被下面的权利要求所定义。而且应当注意,在此涉及的任何专利、申请和出版物,其全部内容被结合参考。
Claims (50)
1.一种对样品的至少一部分成像的装置,包括:
提供电磁辐射的第一干涉测量(inferometric)装置;和
配置以接收电磁辐射的第二装置,并配置以产生合成电磁强度分布,
其中,沿着特定方向,对于至少预定距离该强度分布近似为常数。
2.根据权利要求1的装置,其中第二装置是光学装置,该装置被配置成光学成像的样品。
3.根据权利要求1的装置,其中第二装置是旋转三棱镜。
4.根据权利要求1的装置,其中第二装置是折射光学元件。
5.根据权利要求1的装置,其中第二装置是环。
6.根据权利要求1的装置,其中第二装置包括衍射元件和透镜的组合。
7.根据权利要求1的装置,其中第二装置包括变迹透镜、全息图和衍射元件的组合。
8.根据权利要求1的装置,其中强度分布是贝赛尔射束。
9.根据权利要求1的装置,还包括适合与第二装置结合的第三装置,以便转换强度分布和样品中的至少一个。
10.根据权利要求9的装置,其中对强度分布和样品中的至少一个进行转换以产生具有2维或更多维的图像。
11.根据权利要求1的装置,其中强度分布半幅值全宽小于10μm。
12.根据权利要求1的装置,其中预定距离至少是50μm。
13.根据权利要求1的装置,其中强度分布的至少一部分包括非高斯分布。
14.根据权利要求1的装置,还包括配置的第四装置以接收与强度分布有关的消息,并基于接收的消息显示图像。
15.一种对至少一部分样品进行成像的装置,包括:
提供电磁辐射的第一干涉测量装置;和
配置以接收电磁辐射的第二装置,并配置以产生合成电磁强度分布,
其中,沿着特定方向,强度分布的至少两分区的宽度近似相同。
16.根据权利要求15的装置,其中特定方向近似为垂直方向。
17.根据权利要求15的装置,其中第二装置包括多个透镜。
18.根据权利要求15的装置,其中一个分区至少部分的位于另一分区之上。
19.根据权利要求51的装置,其中强度分布半幅值全宽小于10μm。
20.根据权利要求15的装置,其中强度分布的至少一部分包括非高斯分布。
21.根据权利要求15的装置,还包括适合与第二装置结合的第三装置,以便转换强度分布和样品中的至少一个。
22.根据权利要求21的装置,其中对强度分布和样品中的至少一个进行转换以产生具有2维或更多维的图像。
23.一种对样品的至少一部分成像的方法,包括:
a)使用干涉测量装置提供电磁辐射;
b)接收电磁辐射并产生合成电磁强度分布,其中,沿着特定方向,对于至少预定距离该强度分布近似为常数。
24.根据权利要求23的方法,其中利用光学装置执行步骤(b),该装置被配置成光学成像样品。
25.根据权利要求23的方法,其中使用旋转三棱透镜执行步骤(b)。
26.根据权利要求23的方法,其中使用折射光学元件执行步骤(b)。
27.根据权利要求23的方法,其中使用环执行步骤(b)。
28.根据权利要求23的方法,其中使用衍射元件和透镜的组合来执行步骤(b)。
29.根据权利要求23的方法,其中使用变迹透镜、全息图和衍射元件的组合执行步骤(b)。
30.根据权利要求23的方法,其中强度分布是贝赛尔射束。
31.根据权利要求23的方法,还包括对强度分布和样品中的至少一个进行转换。
32.根据权利要求31的方法,其中对强度分布和样品中的至少一个进行转换以产生具有2维或更多维的图像。
33.根据权利要求23的方法,其中强度分布半幅值全宽小于10μm。
34.根据权利要求23的方法,其中预定距离至少是50μm。
35.根据权利要求23的方法,其中强度分布的至少一部分包括非高斯分布。
36.根据权利要求23的方法,还包括接收与强度分布有关的消息的步骤,并基于接收的消息显示图像。
37.一种对样品的至少一部分成像的方法,包括:
a)使用干涉测量装置提供电磁辐射;和
b)接收电磁辐射,并产生合成电磁强度分布,其中,沿着特定方向,强度分布的至少两部分的宽度近似相同。
38.根据权利要求37的方法,其中利用光学装置执行步骤(b),该装置被配置成光学成像该样品。
39.根据权利要求37的方法,其中使用旋转三棱透镜执行步骤(b)。
40.根据权利要求37的方法,其中使用折射光学元件执行步骤(b)。
41.根据权利要求37的方法,其中使用环执行步骤(b)。
42.根据权利要求37的方法,其中使用衍射元件和透镜的组合来执行步骤(b)。
43.根据权利要求37的方法,其中使用变迹透镜、全息图和衍射元件的组合执行步骤(b)。
44.据权利要求37的方法,其中强度分布是贝赛尔射束。
45.据权利要求37的方法,还包括对强度分布和样品中的至少一个进行转换。
46.根据权利要求45的方法,其中对强度分布和样品中的至少一个进行转换以产生具有2维或更多维的图像。
47.权利要求37的方法,其中强度分布半幅值全宽小于10μm。
48.根据权利要求37的方法,其中预定距离至少是50μm。
49.根据权利要求23的方法,其中强度分布的至少一部分包括非高斯分布。
50.根据权利要求37的方法,还包括接收与强度分布有关的消息的步骤,并基于接收的消息显示图像。
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Families Citing this family (233)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE454845T1 (de) | 2000-10-30 | 2010-01-15 | Gen Hospital Corp | Optische systeme zur gewebeanalyse |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
AT411269B (de) * | 2001-11-05 | 2003-11-25 | Salzburger Aluminium Ag | Aluminium-silizium-legierungen mit verbesserten mechanischen eigenschaften |
CN1741768A (zh) * | 2003-01-24 | 2006-03-01 | 通用医疗有限公司 | 利用低相干干涉测量法识别组织的系统和方法 |
EP1611470B1 (en) | 2003-03-31 | 2015-10-14 | The General Hospital Corporation | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
EP2011434A3 (en) | 2003-06-06 | 2009-03-25 | The General Hospital Corporation | Process and apparatus for a wavelength tuned light source |
DE202004021942U1 (de) | 2003-09-12 | 2013-05-13 | Vessix Vascular, Inc. | Auswählbare exzentrische Remodellierung und/oder Ablation von atherosklerotischem Material |
EP2278287B1 (en) | 2003-10-27 | 2016-09-07 | The General Hospital Corporation | Method and apparatus for performing optical imaging using frequency-domain interferometry |
US7447408B2 (en) | 2004-07-02 | 2008-11-04 | The General Hospital Corproation | Imaging system and related techniques |
EP1782020B1 (en) | 2004-08-06 | 2012-10-03 | The General Hospital Corporation | Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography |
JP5324095B2 (ja) | 2004-08-24 | 2013-10-23 | ザ ジェネラル ホスピタル コーポレイション | 血管セグメントを画像化する方法および装置 |
WO2006024014A2 (en) | 2004-08-24 | 2006-03-02 | The General Hospital Corporation | Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample |
US9125667B2 (en) | 2004-09-10 | 2015-09-08 | Vessix Vascular, Inc. | System for inducing desirable temperature effects on body tissue |
US8396548B2 (en) | 2008-11-14 | 2013-03-12 | Vessix Vascular, Inc. | Selective drug delivery in a lumen |
US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
US7366376B2 (en) | 2004-09-29 | 2008-04-29 | The General Hospital Corporation | System and method for optical coherence imaging |
US8922781B2 (en) | 2004-11-29 | 2014-12-30 | The General Hospital Corporation | Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample |
EP1850735A2 (en) * | 2005-02-10 | 2007-11-07 | Lightlab Imaging, Inc. | Optical coherence tomography apparatus and methods |
JP2008538612A (ja) * | 2005-04-22 | 2008-10-30 | ザ ジェネラル ホスピタル コーポレイション | スペクトルドメイン偏光感受型光コヒーレンストモグラフィを提供することの可能な構成、システム、及び方法 |
JP5684452B2 (ja) | 2005-04-28 | 2015-03-11 | ザ ジェネラル ホスピタル コーポレイション | 光干渉測定法により解剖学的構造に関連する情報を評価するためのシステム、方法及びソフトウエア装置 |
EP1889037A2 (en) | 2005-06-01 | 2008-02-20 | The General Hospital Corporation | Apparatus, method and system for performing phase-resolved optical frequency domain imaging |
KR101387454B1 (ko) | 2005-08-09 | 2014-04-22 | 더 제너럴 하스피탈 코포레이션 | 광간섭 단층촬영법에서 편광 기반 직교 복조를 수행하기위한 장치, 방법 및 저장 매체 |
US8784336B2 (en) | 2005-08-24 | 2014-07-22 | C. R. Bard, Inc. | Stylet apparatuses and methods of manufacture |
US7872759B2 (en) | 2005-09-29 | 2011-01-18 | The General Hospital Corporation | Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures |
JP2009523574A (ja) * | 2006-01-18 | 2009-06-25 | ザ ジェネラル ホスピタル コーポレイション | 1つ又は複数の内視鏡顕微鏡検査法を使用してデータを生成するシステム及び方法 |
WO2007084995A2 (en) | 2006-01-19 | 2007-07-26 | The General Hospital Corporation | Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof |
WO2007084903A2 (en) | 2006-01-19 | 2007-07-26 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements |
US20090128824A1 (en) * | 2006-01-24 | 2009-05-21 | Rainer Leitgeb | Optical imaging system with extended depth of focus |
JP4483793B2 (ja) * | 2006-01-27 | 2010-06-16 | セイコーエプソン株式会社 | 微細構造体の製造方法及び製造装置 |
WO2007149603A2 (en) | 2006-02-01 | 2007-12-27 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
US10426548B2 (en) | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
WO2007101026A2 (en) | 2006-02-24 | 2007-09-07 | The General Hospital Corporation | Methods and systems for performing angle-resolved fourier-domain optical coherence tomography |
US8019435B2 (en) | 2006-05-02 | 2011-09-13 | Boston Scientific Scimed, Inc. | Control of arterial smooth muscle tone |
EP3150110B1 (en) | 2006-05-10 | 2020-09-02 | The General Hospital Corporation | Processes, arrangements and systems for providing frequency domain imaging of a sample |
US20080024767A1 (en) * | 2006-07-28 | 2008-01-31 | Peter Seitz | Imaging optical coherence tomography with dynamic coherent focus |
US20100165335A1 (en) * | 2006-08-01 | 2010-07-01 | The General Hospital Corporation | Systems and methods for receiving and/or analyzing information associated with electro-magnetic radiation |
CN100401974C (zh) * | 2006-09-08 | 2008-07-16 | 浙江大学 | 一种实现光学相干层析成像轴向超分辨的方法及系统 |
AU2007310986B2 (en) | 2006-10-18 | 2013-07-04 | Boston Scientific Scimed, Inc. | Inducing desirable temperature effects on body tissue |
AU2007310988B2 (en) | 2006-10-18 | 2013-08-15 | Vessix Vascular, Inc. | Tuned RF energy and electrical tissue characterization for selective treatment of target tissues |
US8838213B2 (en) | 2006-10-19 | 2014-09-16 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) |
US7794407B2 (en) | 2006-10-23 | 2010-09-14 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
US8388546B2 (en) | 2006-10-23 | 2013-03-05 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
US20080118886A1 (en) * | 2006-11-21 | 2008-05-22 | Rongguang Liang | Apparatus for dental oct imaging |
CN101568296B (zh) * | 2006-12-22 | 2011-11-16 | 皇家飞利浦电子股份有限公司 | 具有两个成像模块的成像系统 |
US7949019B2 (en) * | 2007-01-19 | 2011-05-24 | The General Hospital | Wavelength tuning source based on a rotatable reflector |
US20080234567A1 (en) * | 2007-03-19 | 2008-09-25 | The General Hospital Corporation | Apparatus and method for providing a noninvasive diagnosis of internal bleeding |
US10534129B2 (en) | 2007-03-30 | 2020-01-14 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
WO2009033111A2 (en) | 2007-09-06 | 2009-03-12 | Lensx Lasers, Inc. | Precise targeting of surgical photodisruption |
US20090073439A1 (en) * | 2007-09-15 | 2009-03-19 | The General Hospital Corporation | Apparatus, computer-accessible medium and method for measuring chemical and/or molecular compositions of coronary atherosclerotic plaques in anatomical structures |
EP2040059A3 (en) * | 2007-09-19 | 2013-09-04 | FUJIFILM Corporation | Optical tomography imaging system, contact area detecting method and image processing method using the same, and optical tomographic image obtaining method |
US8781555B2 (en) | 2007-11-26 | 2014-07-15 | C. R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
US9636031B2 (en) | 2007-11-26 | 2017-05-02 | C.R. Bard, Inc. | Stylets for use with apparatus for intravascular placement of a catheter |
US8849382B2 (en) | 2007-11-26 | 2014-09-30 | C. R. Bard, Inc. | Apparatus and display methods relating to intravascular placement of a catheter |
CN101925333B (zh) | 2007-11-26 | 2014-02-12 | C·R·巴德股份有限公司 | 用于脉管系统内的导管放置的集成系统 |
US9649048B2 (en) | 2007-11-26 | 2017-05-16 | C. R. Bard, Inc. | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
US9521961B2 (en) | 2007-11-26 | 2016-12-20 | C. R. Bard, Inc. | Systems and methods for guiding a medical instrument |
US10524691B2 (en) | 2007-11-26 | 2020-01-07 | C. R. Bard, Inc. | Needle assembly including an aligned magnetic element |
US10449330B2 (en) | 2007-11-26 | 2019-10-22 | C. R. Bard, Inc. | Magnetic element-equipped needle assemblies |
US10751509B2 (en) | 2007-11-26 | 2020-08-25 | C. R. Bard, Inc. | Iconic representations for guidance of an indwelling medical device |
US20090225324A1 (en) * | 2008-01-17 | 2009-09-10 | The General Hospital Corporation | Apparatus for providing endoscopic high-speed optical coherence tomography |
US11123047B2 (en) | 2008-01-28 | 2021-09-21 | The General Hospital Corporation | Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood |
US8478382B2 (en) | 2008-02-11 | 2013-07-02 | C. R. Bard, Inc. | Systems and methods for positioning a catheter |
JP5607610B2 (ja) | 2008-05-07 | 2014-10-15 | ザ ジェネラル ホスピタル コーポレイション | 構造の特徴を決定する装置、装置の作動方法およびコンピュータアクセス可能な媒体 |
US9254089B2 (en) | 2008-07-14 | 2016-02-09 | The General Hospital Corporation | Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample |
US9901714B2 (en) | 2008-08-22 | 2018-02-27 | C. R. Bard, Inc. | Catheter assembly including ECG sensor and magnetic assemblies |
US8437833B2 (en) | 2008-10-07 | 2013-05-07 | Bard Access Systems, Inc. | Percutaneous magnetic gastrostomy |
EP3173043A1 (en) | 2008-11-11 | 2017-05-31 | Shifamed Holdings, LLC | Low profile electrode assembly |
US9795442B2 (en) | 2008-11-11 | 2017-10-24 | Shifamed Holdings, Llc | Ablation catheters |
AU2009314133B2 (en) | 2008-11-17 | 2015-12-10 | Vessix Vascular, Inc. | Selective accumulation of energy with or without knowledge of tissue topography |
JP5795576B2 (ja) | 2009-06-12 | 2015-10-14 | バード・アクセス・システムズ,インコーポレーテッド | 心電図(ecg)信号を使用して心臓内またはその近くに血管内デバイスを位置決めするコンピュータベースの医療機器の作動方法 |
US9532724B2 (en) | 2009-06-12 | 2017-01-03 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
US8323241B2 (en) | 2009-06-24 | 2012-12-04 | Shifamed Holdings, Llc | Steerable medical delivery devices and methods of use |
BR112012001042A2 (pt) * | 2009-07-14 | 2016-11-22 | Gen Hospital Corp | equipamento e método de medição do fluxo de fluído dentro de estrutura anatômica. |
WO2011019760A2 (en) | 2009-08-10 | 2011-02-17 | Romedex International Srl | Devices and methods for endovascular electrography |
US8937723B2 (en) * | 2009-10-01 | 2015-01-20 | Thunder Bay Regional Research Institute | Apparatus and methods for optical coherence tomography and confocal microscopy |
US11103213B2 (en) | 2009-10-08 | 2021-08-31 | C. R. Bard, Inc. | Spacers for use with an ultrasound probe |
US10639008B2 (en) | 2009-10-08 | 2020-05-05 | C. R. Bard, Inc. | Support and cover structures for an ultrasound probe head |
US8767216B2 (en) * | 2009-10-13 | 2014-07-01 | California Institute Of Technology | Holographically illuminated imaging devices |
US9492322B2 (en) | 2009-11-16 | 2016-11-15 | Alcon Lensx, Inc. | Imaging surgical target tissue by nonlinear scanning |
US8860948B2 (en) * | 2010-01-22 | 2014-10-14 | Ben Gurion University of the Negev Research and Development Authority Ltd.; Bar Ilan University | High resolution extended depth of field optical coherence tomography |
EP2531098B1 (en) | 2010-02-02 | 2020-07-15 | C.R. Bard, Inc. | Apparatus and method for catheter navigation and tip location |
US8265364B2 (en) | 2010-02-05 | 2012-09-11 | Alcon Lensx, Inc. | Gradient search integrated with local imaging in laser surgical systems |
US8414564B2 (en) | 2010-02-18 | 2013-04-09 | Alcon Lensx, Inc. | Optical coherence tomographic system for ophthalmic surgery |
WO2011106327A2 (en) * | 2010-02-23 | 2011-09-01 | California Institute Of Technology | High resolution imaging devices with wide field and extended focus |
HUE051135T2 (hu) * | 2010-03-05 | 2021-03-01 | Massachusetts Gen Hospital | Rendszerek mikroszkópikus képek elõállítására legalább egy anatómiai szerkezetrõl adott felbontással |
CN102917748B (zh) | 2010-03-24 | 2015-04-01 | 施菲姆德控股有限责任公司 | 血管内组织破坏 |
KR20130108067A (ko) | 2010-04-09 | 2013-10-02 | 베식스 바스큘라 인코포레이티드 | 조직 치료를 위한 발전 및 제어 장치 |
US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
AU2011252976A1 (en) | 2010-05-12 | 2012-11-08 | Shifamed Holdings, Llc | Low profile electrode assembly |
US9655677B2 (en) | 2010-05-12 | 2017-05-23 | Shifamed Holdings, Llc | Ablation catheters including a balloon and electrodes |
JP5778762B2 (ja) | 2010-05-25 | 2015-09-16 | ザ ジェネラル ホスピタル コーポレイション | 光コヒーレンストモグラフィー画像のスペクトル解析のための装置及び方法 |
WO2011149972A2 (en) | 2010-05-25 | 2011-12-01 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
WO2011150376A1 (en) | 2010-05-28 | 2011-12-01 | C.R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
MX2012013858A (es) | 2010-05-28 | 2013-04-08 | Bard Inc C R | Sistema de guia de insercion para agujas y componentes medicos. |
JP6066901B2 (ja) | 2010-06-03 | 2017-01-25 | ザ ジェネラル ホスピタル コーポレイション | 1つまたは複数の管腔器官内または管腔器官にある構造を撮像するための装置およびデバイスのための方法 |
US8473067B2 (en) | 2010-06-11 | 2013-06-25 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
US8398236B2 (en) | 2010-06-14 | 2013-03-19 | Alcon Lensx, Inc. | Image-guided docking for ophthalmic surgical systems |
US9358365B2 (en) | 2010-07-30 | 2016-06-07 | Boston Scientific Scimed, Inc. | Precision electrode movement control for renal nerve ablation |
US9084609B2 (en) | 2010-07-30 | 2015-07-21 | Boston Scientific Scime, Inc. | Spiral balloon catheter for renal nerve ablation |
US9408661B2 (en) | 2010-07-30 | 2016-08-09 | Patrick A. Haverkost | RF electrodes on multiple flexible wires for renal nerve ablation |
US9155589B2 (en) | 2010-07-30 | 2015-10-13 | Boston Scientific Scimed, Inc. | Sequential activation RF electrode set for renal nerve ablation |
US9463062B2 (en) | 2010-07-30 | 2016-10-11 | Boston Scientific Scimed, Inc. | Cooled conductive balloon RF catheter for renal nerve ablation |
MX338127B (es) | 2010-08-20 | 2016-04-04 | Bard Inc C R | Reconfirmacion de colocacion de una punta de cateter asistida por ecg. |
WO2012033957A2 (en) | 2010-09-09 | 2012-03-15 | California Institute Of Technology | Delayed emission detection devices and methods |
US9532708B2 (en) | 2010-09-17 | 2017-01-03 | Alcon Lensx, Inc. | Electronically controlled fixation light for ophthalmic imaging systems |
US8974451B2 (en) | 2010-10-25 | 2015-03-10 | Boston Scientific Scimed, Inc. | Renal nerve ablation using conductive fluid jet and RF energy |
EP2632324A4 (en) | 2010-10-27 | 2015-04-22 | Gen Hospital Corp | DEVICES, SYSTEMS AND METHOD FOR MEASURING BLOOD PRESSURE IN AT LEAST ONE VESSEL |
US9220558B2 (en) | 2010-10-27 | 2015-12-29 | Boston Scientific Scimed, Inc. | RF renal denervation catheter with multiple independent electrodes |
CN103189009B (zh) | 2010-10-29 | 2016-09-07 | C·R·巴德股份有限公司 | 医疗设备的生物阻抗辅助放置 |
JP5535043B2 (ja) * | 2010-11-08 | 2014-07-02 | 三菱電機株式会社 | 樹脂識別装置 |
US9028485B2 (en) | 2010-11-15 | 2015-05-12 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
US9668811B2 (en) | 2010-11-16 | 2017-06-06 | Boston Scientific Scimed, Inc. | Minimally invasive access for renal nerve ablation |
US9089350B2 (en) | 2010-11-16 | 2015-07-28 | Boston Scientific Scimed, Inc. | Renal denervation catheter with RF electrode and integral contrast dye injection arrangement |
US9326751B2 (en) | 2010-11-17 | 2016-05-03 | Boston Scientific Scimed, Inc. | Catheter guidance of external energy for renal denervation |
US9060761B2 (en) | 2010-11-18 | 2015-06-23 | Boston Scientific Scime, Inc. | Catheter-focused magnetic field induced renal nerve ablation |
US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
US9192435B2 (en) | 2010-11-22 | 2015-11-24 | Boston Scientific Scimed, Inc. | Renal denervation catheter with cooled RF electrode |
US20120157993A1 (en) | 2010-12-15 | 2012-06-21 | Jenson Mark L | Bipolar Off-Wall Electrode Device for Renal Nerve Ablation |
WO2012100095A1 (en) | 2011-01-19 | 2012-07-26 | Boston Scientific Scimed, Inc. | Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury |
US9999354B2 (en) * | 2011-01-21 | 2018-06-19 | National Research Council Of Canada | Biological tissue inspection method and system |
US9086536B2 (en) | 2011-03-09 | 2015-07-21 | California Institute Of Technology | Talbot imaging devices and systems |
JP5610063B2 (ja) * | 2011-03-24 | 2014-10-22 | 株式会社ニコン | 観察装置および観察方法 |
US8946619B2 (en) | 2011-04-20 | 2015-02-03 | California Institute Of Technology | Talbot-illuminated imaging devices, systems, and methods for focal plane tuning |
US9179843B2 (en) | 2011-04-21 | 2015-11-10 | Hassan Ghaderi MOGHADDAM | Method and system for optically evaluating proximity to the inferior alveolar nerve in situ |
US8459794B2 (en) | 2011-05-02 | 2013-06-11 | Alcon Lensx, Inc. | Image-processor-controlled misalignment-reduction for ophthalmic systems |
AU2012250729B2 (en) | 2011-05-03 | 2016-12-01 | Shifamed Holdings, Llc | Steerable delivery sheaths |
US9622913B2 (en) | 2011-05-18 | 2017-04-18 | Alcon Lensx, Inc. | Imaging-controlled laser surgical system |
KR20140051284A (ko) | 2011-07-06 | 2014-04-30 | 씨. 알. 바드, 인크. | 삽입 유도 시스템을 위한 바늘 길이 결정 및 교정 |
TWI447352B (zh) * | 2011-07-08 | 2014-08-01 | 私立中原大學 | 光學斷層攝影系統 |
WO2013013049A1 (en) | 2011-07-19 | 2013-01-24 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
CN103813745B (zh) | 2011-07-20 | 2016-06-29 | 波士顿科学西美德公司 | 用以可视化、对准和消融神经的经皮装置及方法 |
JP6106669B2 (ja) | 2011-07-22 | 2017-04-05 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | ヘリカル・ガイド内に配置可能な神経調節要素を有する神経調節システム |
USD724745S1 (en) | 2011-08-09 | 2015-03-17 | C. R. Bard, Inc. | Cap for an ultrasound probe |
USD699359S1 (en) | 2011-08-09 | 2014-02-11 | C. R. Bard, Inc. | Ultrasound probe head |
WO2013029047A1 (en) | 2011-08-25 | 2013-02-28 | The General Hospital Corporation | Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures |
US8398238B1 (en) | 2011-08-26 | 2013-03-19 | Alcon Lensx, Inc. | Imaging-based guidance system for ophthalmic docking using a location-orientation analysis |
WO2013055826A1 (en) | 2011-10-10 | 2013-04-18 | Boston Scientific Scimed, Inc. | Medical devices including ablation electrodes |
US10085799B2 (en) | 2011-10-11 | 2018-10-02 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
US9420955B2 (en) | 2011-10-11 | 2016-08-23 | Boston Scientific Scimed, Inc. | Intravascular temperature monitoring system and method |
US9364284B2 (en) | 2011-10-12 | 2016-06-14 | Boston Scientific Scimed, Inc. | Method of making an off-wall spacer cage |
WO2013058962A1 (en) | 2011-10-18 | 2013-04-25 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
US9341783B2 (en) | 2011-10-18 | 2016-05-17 | The General Hospital Corporation | Apparatus and methods for producing and/or providing recirculating optical delay(s) |
EP2768568B1 (en) | 2011-10-18 | 2020-05-06 | Boston Scientific Scimed, Inc. | Integrated crossing balloon catheter |
WO2013070775A1 (en) | 2011-11-07 | 2013-05-16 | C.R. Bard, Inc | Ruggedized ultrasound hydrogel insert |
EP2775948B1 (en) | 2011-11-08 | 2018-04-04 | Boston Scientific Scimed, Inc. | Ostial renal nerve ablation |
US9119600B2 (en) | 2011-11-15 | 2015-09-01 | Boston Scientific Scimed, Inc. | Device and methods for renal nerve modulation monitoring |
US9119632B2 (en) | 2011-11-21 | 2015-09-01 | Boston Scientific Scimed, Inc. | Deflectable renal nerve ablation catheter |
US9066784B2 (en) | 2011-12-19 | 2015-06-30 | Alcon Lensx, Inc. | Intra-surgical optical coherence tomographic imaging of cataract procedures |
US9023016B2 (en) | 2011-12-19 | 2015-05-05 | Alcon Lensx, Inc. | Image processor for intra-surgical optical coherence tomographic imaging of laser cataract procedures |
US20130163003A1 (en) * | 2011-12-21 | 2013-06-27 | Ole Massow | Apparatus and method for optical swept-source coherence tomography |
US9265969B2 (en) | 2011-12-21 | 2016-02-23 | Cardiac Pacemakers, Inc. | Methods for modulating cell function |
WO2013096916A2 (en) | 2011-12-23 | 2013-06-27 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
US9433760B2 (en) | 2011-12-28 | 2016-09-06 | Boston Scientific Scimed, Inc. | Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements |
US9050106B2 (en) | 2011-12-29 | 2015-06-09 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
JP5655805B2 (ja) * | 2012-03-21 | 2015-01-21 | 住友電気工業株式会社 | 光プローブおよび光学的測定方法 |
EP2833776A4 (en) | 2012-03-30 | 2015-12-09 | Gen Hospital Corp | IMAGING SYSTEM, METHOD AND DISTAL FIXATION FOR MULTIDIRECTIONAL FIELD ENDOSCOPY |
US8961550B2 (en) | 2012-04-17 | 2015-02-24 | Indian Wells Medical, Inc. | Steerable endoluminal punch |
US10660703B2 (en) | 2012-05-08 | 2020-05-26 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices |
WO2013177154A1 (en) | 2012-05-21 | 2013-11-28 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
CN104837413B (zh) | 2012-06-15 | 2018-09-11 | C·R·巴德股份有限公司 | 检测超声探测器上可移除帽的装置及方法 |
JP5828811B2 (ja) * | 2012-07-23 | 2015-12-09 | キヤノン株式会社 | 撮像装置及びその制御方法 |
EP2690395A1 (de) * | 2012-07-24 | 2014-01-29 | Hexagon Technology Center GmbH | Interferometrische Entfernungsmessanordnung und ebensolches Verfahren |
JP6227652B2 (ja) | 2012-08-22 | 2017-11-08 | ザ ジェネラル ホスピタル コーポレイション | ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体 |
US10321946B2 (en) | 2012-08-24 | 2019-06-18 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices with weeping RF ablation balloons |
US9173696B2 (en) | 2012-09-17 | 2015-11-03 | Boston Scientific Scimed, Inc. | Self-positioning electrode system and method for renal nerve modulation |
US10398464B2 (en) | 2012-09-21 | 2019-09-03 | Boston Scientific Scimed, Inc. | System for nerve modulation and innocuous thermal gradient nerve block |
US10549127B2 (en) | 2012-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Self-cooling ultrasound ablation catheter |
CN104869930B (zh) | 2012-10-10 | 2020-12-25 | 波士顿科学国际有限公司 | 肾神经调制装置和方法 |
WO2014085911A1 (en) | 2012-12-05 | 2014-06-12 | Tornado Medical Systems, Inc. | System and method for wide field oct imaging |
KR20140089129A (ko) | 2013-01-04 | 2014-07-14 | 삼성전자주식회사 | 광학 줌 프로브 |
JP6053138B2 (ja) * | 2013-01-24 | 2016-12-27 | 株式会社日立エルジーデータストレージ | 光断層観察装置及び光断層観察方法 |
WO2014117130A1 (en) | 2013-01-28 | 2014-07-31 | The General Hospital Corporation | Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging |
WO2014120791A1 (en) | 2013-01-29 | 2014-08-07 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
US11179028B2 (en) | 2013-02-01 | 2021-11-23 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
US9956033B2 (en) | 2013-03-11 | 2018-05-01 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
US9693821B2 (en) | 2013-03-11 | 2017-07-04 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
US9808311B2 (en) | 2013-03-13 | 2017-11-07 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
EP2967734B1 (en) | 2013-03-15 | 2019-05-15 | Boston Scientific Scimed, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
EP4233991A1 (en) | 2013-03-15 | 2023-08-30 | Medtronic Ardian Luxembourg S.à.r.l. | Controlled neuromodulation systems |
US9297845B2 (en) | 2013-03-15 | 2016-03-29 | Boston Scientific Scimed, Inc. | Medical devices and methods for treatment of hypertension that utilize impedance compensation |
EP2967491B1 (en) | 2013-03-15 | 2022-05-11 | The General Hospital Corporation | A transesophageal endoscopic system for determining a mixed venous oxygen saturation of a pulmonary artery |
US10265122B2 (en) | 2013-03-15 | 2019-04-23 | Boston Scientific Scimed, Inc. | Nerve ablation devices and related methods of use |
JP6463731B2 (ja) | 2013-04-08 | 2019-02-06 | アパマ・メディカル・インコーポレーテッド | 映像化システム |
US10098694B2 (en) | 2013-04-08 | 2018-10-16 | Apama Medical, Inc. | Tissue ablation and monitoring thereof |
US10349824B2 (en) | 2013-04-08 | 2019-07-16 | Apama Medical, Inc. | Tissue mapping and visualization systems |
EP2997354A4 (en) | 2013-05-13 | 2017-01-18 | The General Hospital Corporation | Detecting self-interefering fluorescence phase and amplitude |
EP3010437A1 (en) | 2013-06-21 | 2016-04-27 | Boston Scientific Scimed, Inc. | Renal denervation balloon catheter with ride along electrode support |
CN105473092B (zh) | 2013-06-21 | 2019-05-17 | 波士顿科学国际有限公司 | 具有可旋转轴的用于肾神经消融的医疗器械 |
US9707036B2 (en) | 2013-06-25 | 2017-07-18 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation using localized indifferent electrodes |
WO2015002787A1 (en) | 2013-07-01 | 2015-01-08 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
EP3019106A1 (en) | 2013-07-11 | 2016-05-18 | Boston Scientific Scimed, Inc. | Medical device with stretchable electrode assemblies |
WO2015006480A1 (en) | 2013-07-11 | 2015-01-15 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation |
WO2015010074A1 (en) | 2013-07-19 | 2015-01-22 | Boston Scientific Scimed, Inc. | Spiral bipolar electrode renal denervation balloon |
WO2015010133A1 (en) | 2013-07-19 | 2015-01-22 | The General Hospital Corporation | Determining eye motion by imaging retina. with feedback |
EP4349242A2 (en) | 2013-07-19 | 2024-04-10 | The General Hospital Corporation | Imaging apparatus and method which utilizes multidirectional field of view endoscopy |
US10695124B2 (en) | 2013-07-22 | 2020-06-30 | Boston Scientific Scimed, Inc. | Renal nerve ablation catheter having twist balloon |
WO2015013205A1 (en) | 2013-07-22 | 2015-01-29 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
US9668652B2 (en) | 2013-07-26 | 2017-06-06 | The General Hospital Corporation | System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography |
DE102013012692A1 (de) * | 2013-07-31 | 2015-02-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren und Vorrichtung zur Detektion von Fremdkörpern oder anderen Streuzentren in optisch transparenten Behältern |
WO2015027096A1 (en) | 2013-08-22 | 2015-02-26 | Boston Scientific Scimed, Inc. | Flexible circuit having improved adhesion to a renal nerve modulation balloon |
EP3041425B1 (en) | 2013-09-04 | 2022-04-13 | Boston Scientific Scimed, Inc. | Radio frequency (rf) balloon catheter having flushing and cooling capability |
WO2015038947A1 (en) | 2013-09-13 | 2015-03-19 | Boston Scientific Scimed, Inc. | Ablation balloon with vapor deposited cover layer |
CN105592778B (zh) | 2013-10-14 | 2019-07-23 | 波士顿科学医学有限公司 | 高分辨率心脏标测电极阵列导管 |
US11246654B2 (en) | 2013-10-14 | 2022-02-15 | Boston Scientific Scimed, Inc. | Flexible renal nerve ablation devices and related methods of use and manufacture |
AU2014334574B2 (en) | 2013-10-15 | 2017-07-06 | Boston Scientific Scimed, Inc. | Medical device balloon |
US9770606B2 (en) | 2013-10-15 | 2017-09-26 | Boston Scientific Scimed, Inc. | Ultrasound ablation catheter with cooling infusion and centering basket |
CN105636538B (zh) | 2013-10-18 | 2019-01-15 | 波士顿科学国际有限公司 | 具有柔性导线的球囊导管及其使用和制造的相关方法 |
CN105658163B (zh) | 2013-10-25 | 2020-08-18 | 波士顿科学国际有限公司 | 去神经柔性电路中的嵌入式热电偶 |
WO2015103617A1 (en) | 2014-01-06 | 2015-07-09 | Boston Scientific Scimed, Inc. | Tear resistant flex circuit assembly |
WO2015105870A1 (en) | 2014-01-08 | 2015-07-16 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
WO2015116986A2 (en) | 2014-01-31 | 2015-08-06 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
JP6325121B2 (ja) | 2014-02-04 | 2018-05-16 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 双極電極上の温度センサの代替配置 |
US11000679B2 (en) | 2014-02-04 | 2021-05-11 | Boston Scientific Scimed, Inc. | Balloon protection and rewrapping devices and related methods of use |
ES2811323T3 (es) | 2014-02-06 | 2021-03-11 | Bard Inc C R | Sistemas para el guiado y la colocación de un dispositivo intravascular |
US10228556B2 (en) | 2014-04-04 | 2019-03-12 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
WO2015189174A2 (en) | 2014-06-10 | 2015-12-17 | Carl Zeiss Meditec, Inc. | Improved frequency-domain interferometric based imaging systems and methods |
US10912462B2 (en) | 2014-07-25 | 2021-02-09 | The General Hospital Corporation | Apparatus, devices and methods for in vivo imaging and diagnosis |
US10973584B2 (en) | 2015-01-19 | 2021-04-13 | Bard Access Systems, Inc. | Device and method for vascular access |
EP3274037B1 (en) | 2015-03-27 | 2021-11-03 | Kalila Medical, Inc. | Steerable medical devices |
WO2016172706A1 (en) | 2015-04-24 | 2016-10-27 | Shifamed Holdings, Llc | Steerable medical devices, systems, and methods of use |
WO2016210325A1 (en) | 2015-06-26 | 2016-12-29 | C.R. Bard, Inc. | Connector interface for ecg-based catheter positioning system |
EP3373794B1 (en) | 2015-11-09 | 2022-01-05 | Kalila Medical, Inc. | Steering assemblies for medical devices |
CN108348146A (zh) | 2015-11-16 | 2018-07-31 | 阿帕玛医疗公司 | 能量传递装置 |
CN111239708B (zh) * | 2015-12-20 | 2024-01-09 | 苹果公司 | 光检测和测距传感器 |
JP6703839B2 (ja) * | 2016-01-14 | 2020-06-03 | 株式会社トプコン | 眼科計測装置 |
US11000207B2 (en) | 2016-01-29 | 2021-05-11 | C. R. Bard, Inc. | Multiple coil system for tracking a medical device |
US10982947B2 (en) * | 2017-06-12 | 2021-04-20 | Sightline Innovation Inc. | System and method of surface inspection of an object using mulitplexed optical coherence tomography |
WO2019014767A1 (en) | 2017-07-18 | 2019-01-24 | Perimeter Medical Imaging, Inc. | SAMPLE CONTAINER FOR STABILIZING AND ALIGNING EXCISED ORGANIC TISSUE SAMPLES FOR EX VIVO ANALYSIS |
CN108036726B (zh) * | 2017-12-05 | 2020-12-22 | 中国科学院合肥物质科学研究院 | 一种使用保偏光纤和双微透镜测量纳米线位移的装置 |
JP6880513B2 (ja) * | 2018-03-13 | 2021-06-02 | オムロン株式会社 | 光学計測装置及び光学計測方法 |
US10992079B2 (en) | 2018-10-16 | 2021-04-27 | Bard Access Systems, Inc. | Safety-equipped connection systems and methods thereof for establishing electrical connections |
WO2021009723A1 (en) | 2019-07-17 | 2021-01-21 | Scoptonic Sp. Z O.O. | High sensitivity optical devices using pupil splittig means |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4965441A (en) * | 1988-01-27 | 1990-10-23 | Commissariat A L'energie Atomique | Method for the scanning confocal light-optical microscopic and indepth examination of an extended field and devices for implementing said method |
EP0627643A2 (en) * | 1993-06-03 | 1994-12-07 | Hamamatsu Photonics K.K. | Laser scanning optical system using axicon |
WO2001042735A1 (en) * | 1999-12-09 | 2001-06-14 | Oti Ophthalmic Technologies Inc. | Optical mapping apparatus with adjustable depth resolution |
Family Cites Families (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US347528A (en) | 1886-08-17 | speee | ||
US2339754A (en) | 1941-03-04 | 1944-01-25 | Westinghouse Electric & Mfg Co | Supervisory apparatus |
US4300816A (en) | 1979-08-30 | 1981-11-17 | United Technologies Corporation | Wide band multicore optical fiber |
US4295738A (en) | 1979-08-30 | 1981-10-20 | United Technologies Corporation | Fiber optic strain sensor |
US5065331A (en) | 1981-05-18 | 1991-11-12 | Vachon Reginald I | Apparatus and method for determining the stress and strain in pipes, pressure vessels, structural members and other deformable bodies |
US4601036A (en) | 1982-09-30 | 1986-07-15 | Honeywell Inc. | Rapidly tunable laser |
CH663466A5 (fr) | 1983-09-12 | 1987-12-15 | Battelle Memorial Institute | Procede et dispositif pour determiner la position d'un objet par rapport a une reference. |
US4631498A (en) | 1985-04-26 | 1986-12-23 | Hewlett-Packard Company | CW Laser wavemeter/frequency locking technique |
US5040889A (en) | 1986-05-30 | 1991-08-20 | Pacific Scientific Company | Spectrometer with combined visible and ultraviolet sample illumination |
US4770492A (en) | 1986-10-28 | 1988-09-13 | Spectran Corporation | Pressure or strain sensitive optical fiber |
JPH0760273B2 (ja) * | 1987-10-26 | 1995-06-28 | キヤノン株式会社 | 磁性現像剤 |
FR2626367B1 (fr) | 1988-01-25 | 1990-05-11 | Thomson Csf | Capteur de temperature multipoints a fibre optique |
US4925302A (en) | 1988-04-13 | 1990-05-15 | Hewlett-Packard Company | Frequency locking device |
ATE158659T1 (de) | 1988-07-13 | 1997-10-15 | Optiscan Pty Ltd | Confokales abtast-endoskop |
GB8817672D0 (en) | 1988-07-25 | 1988-09-01 | Sira Ltd | Optical apparatus |
US4868834A (en) | 1988-09-14 | 1989-09-19 | The United States Of America As Represented By The Secretary Of The Army | System for rapidly tuning a low pressure pulsed laser |
DE3833602A1 (de) | 1988-10-03 | 1990-02-15 | Krupp Gmbh | Spektrometer zur gleichzeitigen intensitaetsmessung in verschiedenen spektralbereichen |
ATE133545T1 (de) | 1988-12-21 | 1996-02-15 | Massachusetts Inst Technology | Verfahren für laserinduzierte fluoreszenz von gewebe |
US5046501A (en) | 1989-01-18 | 1991-09-10 | Wayne State University | Atherosclerotic identification |
US5317389A (en) | 1989-06-12 | 1994-05-31 | California Institute Of Technology | Method and apparatus for white-light dispersed-fringe interferometric measurement of corneal topography |
US5039193A (en) | 1990-04-03 | 1991-08-13 | Focal Technologies Incorporated | Fibre optic single mode rotary joint |
US5262644A (en) | 1990-06-29 | 1993-11-16 | Southwest Research Institute | Remote spectroscopy for raman and brillouin scattering |
US5197470A (en) | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
GB9015793D0 (en) | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
US5127730A (en) | 1990-08-10 | 1992-07-07 | Regents Of The University Of Minnesota | Multi-color laser scanning confocal imaging system |
US5305759A (en) | 1990-09-26 | 1994-04-26 | Olympus Optical Co., Ltd. | Examined body interior information observing apparatus by using photo-pulses controlling gains for depths |
US5202745A (en) | 1990-11-07 | 1993-04-13 | Hewlett-Packard Company | Polarization independent optical coherence-domain reflectometry |
JP3035336B2 (ja) | 1990-11-27 | 2000-04-24 | 興和株式会社 | 血流測定装置 |
US5293872A (en) | 1991-04-03 | 1994-03-15 | Alfano Robert R | Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US5956355A (en) | 1991-04-29 | 1999-09-21 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser |
US6134003A (en) | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US6111645A (en) | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US5748598A (en) | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
US6564087B1 (en) * | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US5321501A (en) | 1991-04-29 | 1994-06-14 | Massachusetts Institute Of Technology | Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample |
US5441053A (en) | 1991-05-03 | 1995-08-15 | University Of Kentucky Research Foundation | Apparatus and method for multiple wavelength of tissue |
DE4128744C1 (zh) | 1991-08-29 | 1993-04-22 | Siemens Ag, 8000 Muenchen, De | |
US5353790A (en) | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
US5248876A (en) | 1992-04-21 | 1993-09-28 | International Business Machines Corporation | Tandem linear scanning confocal imaging system with focal volumes at different heights |
US5486701A (en) | 1992-06-16 | 1996-01-23 | Prometrix Corporation | Method and apparatus for measuring reflectance in two wavelength bands to enable determination of thin film thickness |
US5772597A (en) | 1992-09-14 | 1998-06-30 | Sextant Medical Corporation | Surgical tool end effector |
US5698397A (en) | 1995-06-07 | 1997-12-16 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
US5383467A (en) | 1992-11-18 | 1995-01-24 | Spectrascience, Inc. | Guidewire catheter and apparatus for diagnostic imaging |
ES2102187T3 (es) | 1992-11-18 | 1997-07-16 | Spectrascience Inc | Aparato para diagnostico por formacion de imagenes. |
US5987346A (en) | 1993-02-26 | 1999-11-16 | Benaron; David A. | Device and method for classification of tissue |
DE4310209C2 (de) | 1993-03-29 | 1996-05-30 | Bruker Medizintech | Optische stationäre Bildgebung in stark streuenden Medien |
DE4314189C1 (de) | 1993-04-30 | 1994-11-03 | Bodenseewerk Geraetetech | Vorrichtung zur Untersuchung von Lichtleitfasern aus Glas mittels Heterodyn-Brillouin-Spektroskopie |
US5803082A (en) | 1993-11-09 | 1998-09-08 | Staplevision Inc. | Omnispectramammography |
US5983125A (en) | 1993-12-13 | 1999-11-09 | The Research Foundation Of City College Of New York | Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy |
JP3261244B2 (ja) * | 1993-12-17 | 2002-02-25 | ブラザー工業株式会社 | 走査光学装置 |
US5450203A (en) | 1993-12-22 | 1995-09-12 | Electroglas, Inc. | Method and apparatus for determining an objects position, topography and for imaging |
US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
DE4411017C2 (de) | 1994-03-30 | 1995-06-08 | Alexander Dr Knuettel | Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen |
TW275570B (zh) | 1994-05-05 | 1996-05-11 | Boehringer Mannheim Gmbh | |
US5459325A (en) | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
US6159445A (en) | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
DE69528024T2 (de) | 1994-08-18 | 2003-10-09 | Zeiss Carl | Mit optischer Kohärenz-Tomographie gesteuerter chirurgischer Apparat |
US5491524A (en) | 1994-10-05 | 1996-02-13 | Carl Zeiss, Inc. | Optical coherence tomography corneal mapping apparatus |
US5817144A (en) | 1994-10-25 | 1998-10-06 | Latis, Inc. | Method for contemporaneous application OF laser energy and localized pharmacologic therapy |
US6033721A (en) | 1994-10-26 | 2000-03-07 | Revise, Inc. | Image-based three-axis positioner for laser direct write microchemical reaction |
US5600486A (en) | 1995-01-30 | 1997-02-04 | Lockheed Missiles And Space Company, Inc. | Color separation microlens |
US5526338A (en) | 1995-03-10 | 1996-06-11 | Yeda Research & Development Co. Ltd. | Method and apparatus for storage and retrieval with multilayer optical disks |
US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
US5735276A (en) | 1995-03-21 | 1998-04-07 | Lemelson; Jerome | Method and apparatus for scanning and evaluating matter |
US5785651A (en) | 1995-06-07 | 1998-07-28 | Keravision, Inc. | Distance measuring confocal microscope |
WO1997001167A1 (en) | 1995-06-21 | 1997-01-09 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
ATA107495A (de) | 1995-06-23 | 1996-06-15 | Fercher Adolf Friedrich Dr | Kohärenz-biometrie und -tomographie mit dynamischem kohärentem fokus |
AU1130797A (en) | 1995-08-24 | 1997-03-19 | Purdue Research Foundation | Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media |
US6615071B1 (en) * | 1995-09-20 | 2003-09-02 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
US5719399A (en) | 1995-12-18 | 1998-02-17 | The Research Foundation Of City College Of New York | Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough |
US5840023A (en) | 1996-01-31 | 1998-11-24 | Oraevsky; Alexander A. | Optoacoustic imaging for medical diagnosis |
US5843000A (en) | 1996-05-07 | 1998-12-01 | The General Hospital Corporation | Optical biopsy forceps and method of diagnosing tissue |
ATA84696A (de) | 1996-05-14 | 1998-03-15 | Adolf Friedrich Dr Fercher | Verfahren und anordnungen zur kontrastanhebung in der optischen kohärenztomographie |
US5795295A (en) | 1996-06-25 | 1998-08-18 | Carl Zeiss, Inc. | OCT-assisted surgical microscope with multi-coordinate manipulator |
US5842995A (en) | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
EP0928433A1 (fr) * | 1996-09-27 | 1999-07-14 | Vincent Lauer | Microscope generant une representation tridimensionnelle d'un objet |
DE19640495C2 (de) * | 1996-10-01 | 1999-12-16 | Leica Microsystems | Vorrichtung zur konfokalen Oberflächenvermessung |
US6044288A (en) | 1996-11-08 | 2000-03-28 | Imaging Diagnostics Systems, Inc. | Apparatus and method for determining the perimeter of the surface of an object being scanned |
US5872879A (en) | 1996-11-25 | 1999-02-16 | Boston Scientific Corporation | Rotatable connecting optical fibers |
US5871449A (en) | 1996-12-27 | 1999-02-16 | Brown; David Lloyd | Device and method for locating inflamed plaque in an artery |
US5991697A (en) | 1996-12-31 | 1999-11-23 | The Regents Of The University Of California | Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media |
US5760901A (en) * | 1997-01-28 | 1998-06-02 | Zetetic Institute | Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation |
US6010449A (en) | 1997-02-28 | 2000-01-04 | Lumend, Inc. | Intravascular catheter system for treating a vascular occlusion |
US6120516A (en) | 1997-02-28 | 2000-09-19 | Lumend, Inc. | Method for treating vascular occlusion |
US5968064A (en) | 1997-02-28 | 1999-10-19 | Lumend, Inc. | Catheter system for treating a vascular occlusion |
CA2283949A1 (en) * | 1997-03-13 | 1998-09-17 | Haishan Zeng | Methods and apparatus for detecting the rejection of transplanted tissue |
US5994690A (en) | 1997-03-17 | 1999-11-30 | Kulkarni; Manish D. | Image enhancement in optical coherence tomography using deconvolution |
US6117128A (en) | 1997-04-30 | 2000-09-12 | Kenton W. Gregory | Energy delivery catheter and method for the use thereof |
US5887009A (en) | 1997-05-22 | 1999-03-23 | Optical Biopsy Technologies, Inc. | Confocal optical scanning system employing a fiber laser |
US6002480A (en) | 1997-06-02 | 1999-12-14 | Izatt; Joseph A. | Depth-resolved spectroscopic optical coherence tomography |
AU7711498A (en) * | 1997-06-02 | 1998-12-21 | Joseph A. Izatt | Doppler flow imaging using optical coherence tomography |
US6208415B1 (en) * | 1997-06-12 | 2001-03-27 | The Regents Of The University Of California | Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography |
US5920390A (en) | 1997-06-26 | 1999-07-06 | University Of North Carolina | Fiberoptic interferometer and associated method for analyzing tissue |
US5921926A (en) | 1997-07-28 | 1999-07-13 | University Of Central Florida | Three dimensional optical imaging colposcopy |
US5892583A (en) * | 1997-08-21 | 1999-04-06 | Li; Ming-Chiang | High speed inspection of a sample using superbroad radiation coherent interferometer |
US6069698A (en) | 1997-08-28 | 2000-05-30 | Olympus Optical Co., Ltd. | Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object |
US5920373A (en) | 1997-09-24 | 1999-07-06 | Heidelberg Engineering Optische Messysteme Gmbh | Method and apparatus for determining optical characteristics of a cornea |
US5951482A (en) | 1997-10-03 | 1999-09-14 | Intraluminal Therapeutics, Inc. | Assemblies and methods for advancing a guide wire through body tissue |
US6193676B1 (en) * | 1997-10-03 | 2001-02-27 | Intraluminal Therapeutics, Inc. | Guide wire assembly |
US6091984A (en) | 1997-10-10 | 2000-07-18 | Massachusetts Institute Of Technology | Measuring tissue morphology |
US6134010A (en) | 1997-11-07 | 2000-10-17 | Lucid, Inc. | Imaging system using polarization effects to enhance image quality |
US6048742A (en) | 1998-02-26 | 2000-04-11 | The United States Of America As Represented By The Secretary Of The Air Force | Process for measuring the thickness and composition of thin semiconductor films deposited on semiconductor wafers |
US6831781B2 (en) * | 1998-02-26 | 2004-12-14 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy |
JP4709969B2 (ja) * | 1998-02-26 | 2011-06-29 | ザ ジェネラル ホスピタル コーポレイション | マルチスペクトル符号化を用いた共焦点顕微鏡 |
US6066102A (en) * | 1998-03-09 | 2000-05-23 | Spectrascience, Inc. | Optical biopsy forceps system and method of diagnosing tissue |
US6151522A (en) | 1998-03-16 | 2000-11-21 | The Research Foundation Of Cuny | Method and system for examining biological materials using low power CW excitation raman spectroscopy |
US6384915B1 (en) * | 1998-03-30 | 2002-05-07 | The Regents Of The University Of California | Catheter guided by optical coherence domain reflectometry |
DE19814057B4 (de) * | 1998-03-30 | 2009-01-02 | Carl Zeiss Meditec Ag | Anordnung zur optischen Kohärenztomographie und Kohärenztopographie |
US6175669B1 (en) * | 1998-03-30 | 2001-01-16 | The Regents Of The Universtiy Of California | Optical coherence domain reflectometry guidewire |
US6053613A (en) | 1998-05-15 | 2000-04-25 | Carl Zeiss, Inc. | Optical coherence tomography with new interferometer |
US6549801B1 (en) * | 1998-06-11 | 2003-04-15 | The Regents Of The University Of California | Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity |
EP1100392B1 (en) * | 1998-07-15 | 2009-02-25 | Corazon Technologies, Inc. | devices for reducing the mineral content of vascular calcified lesions |
US6191862B1 (en) * | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6272376B1 (en) * | 1999-01-22 | 2001-08-07 | Cedars-Sinai Medical Center | Time-resolved, laser-induced fluorescence for the characterization of organic material |
US6445944B1 (en) * | 1999-02-01 | 2002-09-03 | Scimed Life Systems | Medical scanning system and related method of scanning |
US6185271B1 (en) * | 1999-02-16 | 2001-02-06 | Richard Estyn Kinsinger | Helical computed tomography with feedback scan control |
US6353693B1 (en) * | 1999-05-31 | 2002-03-05 | Sanyo Electric Co., Ltd. | Optical communication device and slip ring unit for an electronic component-mounting apparatus |
US6208887B1 (en) * | 1999-06-24 | 2001-03-27 | Richard H. Clarke | Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions |
US7426409B2 (en) * | 1999-06-25 | 2008-09-16 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
US6687010B1 (en) * | 1999-09-09 | 2004-02-03 | Olympus Corporation | Rapid depth scanning optical imaging device |
US6393312B1 (en) * | 1999-10-13 | 2002-05-21 | C. R. Bard, Inc. | Connector for coupling an optical fiber tissue localization device to a light source |
US6665075B2 (en) * | 2000-11-14 | 2003-12-16 | Wm. Marshurice University | Interferometric imaging system and method |
US6558324B1 (en) * | 2000-11-22 | 2003-05-06 | Siemens Medical Solutions, Inc., Usa | System and method for strain image display |
US6687007B1 (en) * | 2000-12-14 | 2004-02-03 | Kestrel Corporation | Common path interferometer for spectral image generation |
US6552796B2 (en) * | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
DE10118760A1 (de) * | 2001-04-17 | 2002-10-31 | Med Laserzentrum Luebeck Gmbh | Verfahren zur Ermittlung der Laufzeitverteilung und Anordnung |
US20040166593A1 (en) * | 2001-06-22 | 2004-08-26 | Nolte David D. | Adaptive interferometric multi-analyte high-speed biosensor |
US6685885B2 (en) * | 2001-06-22 | 2004-02-03 | Purdue Research Foundation | Bio-optical compact dist system |
US7006231B2 (en) * | 2001-10-18 | 2006-02-28 | Scimed Life Systems, Inc. | Diffraction grating based interferometric systems and methods |
-
2003
- 2003-01-10 CN CN2009101270098A patent/CN101598685B/zh not_active Expired - Lifetime
- 2003-01-10 WO PCT/US2003/000699 patent/WO2003060423A2/en active Application Filing
- 2003-01-10 US US10/501,268 patent/US7310150B2/en not_active Expired - Lifetime
- 2003-01-10 EP EP03705716A patent/EP1468245B1/en not_active Expired - Lifetime
- 2003-01-10 EP EP10181734.4A patent/EP2290318B1/en not_active Expired - Lifetime
- 2003-01-10 AT AT03705716T patent/ATE503982T1/de not_active IP Right Cessation
- 2003-01-10 DE DE60336534T patent/DE60336534D1/de not_active Expired - Lifetime
- 2003-01-10 EP EP10181750.0A patent/EP2290319B1/en not_active Expired - Lifetime
- 2003-01-10 CN CNA03805597XA patent/CN1639539A/zh active Pending
- 2003-01-10 EP EP20100179690 patent/EP2327954A1/en not_active Ceased
- 2003-01-10 CA CA2473465A patent/CA2473465C/en not_active Expired - Fee Related
- 2003-01-10 AU AU2003207507A patent/AU2003207507A1/en not_active Abandoned
- 2003-01-10 JP JP2003560471A patent/JP2005530128A/ja active Pending
-
2009
- 2009-06-15 AU AU2009202383A patent/AU2009202383B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4965441A (en) * | 1988-01-27 | 1990-10-23 | Commissariat A L'energie Atomique | Method for the scanning confocal light-optical microscopic and indepth examination of an extended field and devices for implementing said method |
EP0627643A2 (en) * | 1993-06-03 | 1994-12-07 | Hamamatsu Photonics K.K. | Laser scanning optical system using axicon |
WO2001042735A1 (en) * | 1999-12-09 | 2001-06-14 | Oti Ophthalmic Technologies Inc. | Optical mapping apparatus with adjustable depth resolution |
Non-Patent Citations (1)
Title |
---|
JOSEPH A.IZATT ET AL.: "Optical Coherence Tomography and Microscopy in Gastrointestinal Tissues", 《IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS》 * |
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EP2327954A1 (en) | 2011-06-01 |
CN101598685B (zh) | 2013-11-06 |
EP1468245A2 (en) | 2004-10-20 |
DE60336534D1 (de) | 2011-05-12 |
EP2290318A1 (en) | 2011-03-02 |
CA2473465C (en) | 2011-04-05 |
AU2003207507A1 (en) | 2003-07-30 |
WO2003060423A2 (en) | 2003-07-24 |
AU2003207507A2 (en) | 2003-07-30 |
JP2005530128A (ja) | 2005-10-06 |
AU2009202383A1 (en) | 2009-07-09 |
US7310150B2 (en) | 2007-12-18 |
EP2290318B1 (en) | 2015-08-26 |
US20050018200A1 (en) | 2005-01-27 |
ATE503982T1 (de) | 2011-04-15 |
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