CN101528282B - 用于流体递送和监测体内分析物的柔性贴片 - Google Patents

用于流体递送和监测体内分析物的柔性贴片 Download PDF

Info

Publication number
CN101528282B
CN101528282B CN2007800394162A CN200780039416A CN101528282B CN 101528282 B CN101528282 B CN 101528282B CN 2007800394162 A CN2007800394162 A CN 2007800394162A CN 200780039416 A CN200780039416 A CN 200780039416A CN 101528282 B CN101528282 B CN 101528282B
Authority
CN
China
Prior art keywords
flexible patch
fluid
combined
patch
fluid delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2007800394162A
Other languages
English (en)
Other versions
CN101528282A (zh
Inventor
加里·阿什利·斯塔福德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Therasense Inc
Abbott Diabetes Care Inc
Original Assignee
Therasense Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therasense Inc filed Critical Therasense Inc
Publication of CN101528282A publication Critical patent/CN101528282A/zh
Application granted granted Critical
Publication of CN101528282B publication Critical patent/CN101528282B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • A61B2560/0252—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using ambient temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0406—Constructional details of apparatus specially shaped apparatus housings
    • A61B2560/0412—Low-profile patch shaped housings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3569—Range sublocal, e.g. between console and disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/005—Parameter used as control input for the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/50—Temperature

Abstract

本发明提供了一种可佩戴的导电性纺织品贴片，该贴片可包括用于监测体内分析物和/或将流体递送至体内的多个特征中的任意一个。在本发明的一种实施方式中，单独的贴片安装系统检测糖尿病患者的葡萄糖水平，并响应于葡萄糖测量结果而提供适合剂量的胰岛素。手持式的用户界面可被用于无线控制该系统和/或接收来自其的信息。在贴片的织物中可形成传导通路。可整合至该柔性贴片的部件包括电源、控制器、发送器、天线、温度传感器及其他传感器、流体泵、输液装置、电通路、开关、控制装置、电极、连接器、电阻器、及其他电路元件。这些部件可以嵌入、织入或涂覆于柔性贴片而不是在表面安装，或者同时也安装于表面。本发明还提供了与该柔性贴片系统的应用相关的方法。

Description

用于流体递送和监测体内分析物的柔性贴片
优先权
本申请要求于2006年10月23日提交的名为“用于流体递送和监测体内分析物的柔性贴片”的序列号为11/552,065的美国专利申请的优先权，将其披露内容以引用方式结合于本文以供参考。
技术领域
本发明涉及用于监测活体中的分析物并向其递送流体的医疗器械，诸如监测葡萄糖水平并将胰岛素递送至糖尿病患者。更具体地，本发明涉及整合于柔性贴片中的分析物监测及流体递送系统。
背景技术
近年来，通常通过刺破指尖或身体其他部位进行采血，将血液施加于手持式测量器中的一次性测试条，并允许该测量器和测试条进行血液的电化学测试来确定当前的葡萄糖浓度，从而测量糖尿病患者的血糖水平。这种不连续的体外测试每天通常要至少进行多次。目前正在开发连续的体内葡萄糖监测装置以代替体外装置。这些连续性系统中的一些采用一次性的、经皮的传感器，该传感器被插入到皮肤内以测量间质液中的葡萄糖浓度。该传感器的一部分从皮肤突出，并与通过粘结贴附至皮肤的耐用控制器和发送器单元连接。无线手持式装置与安装于皮肤的发送器和传感器结合使用，以周期性地接收葡萄糖读数，例如每分钟一次。每隔三天、五天或七天，将一次性传感器除去并替换一个新的传感器，将该新的传感器与可再用的控制器和发送器单元再次连接。利用这样的安排，可利用手持式装置连续检测糖尿病患者的葡萄糖水平。于2001年1月16日授予TheraSense，Inc.的美国专利第6,175,752号披露了这种连续式葡萄糖监测系统的详细描述及其使用，将其全部内容以引用方式结合于本文以供参考。
便携式胰岛素泵已被广泛使用，糖尿病患者利用它在较长时间内自动递送胰岛素。目前可用的胰岛素泵采用普通的泵送技术，注射泵。在注射泵中，通过利用精密步进电机使螺杆转动从而使注射器的柱塞向前推进。随着柱塞的前进，流体被挤出注射器，通过导管进入患者体内。胰岛素泵需要以近似连续的方式非常准确地向典型糖尿病患者递送其所需的相对少量的胰岛素(每天约0.1至约1.0cm3)。还可以通过调节该电动机的步进速率来适应不同个体对胰岛素的需求(例如不同的基础率和输注剂量)而在较大范围内容易地调节胰岛素泵的递送速率。除了可更换的胰岛素贮器、螺杆及步进电机之外，胰岛素泵包括电池、控制器及相关电子器件，并通常包括显示器和用户控制装置。典型的胰岛素泵大约为一副牌的大小，并可佩戴在衣服内或利用带夹(belt clip)附着。一次性输液装置与泵连接并将胰岛素递送至患者。该输液装置包括插入穿过皮肤的插管、将插管保持在适当位置的粘结支座、以及将插管连接至泵的一段导管。
上述的连续式葡萄糖监测及胰岛素递送系统具有许多缺点。目前正在开发的安放于皮肤上的发送器的刚性的、平的安装表面会使得佩戴起来很不舒服。另外，由于这些发送器装置与其要安装至的身体部位不配合，从而限制了可将其附着于皮肤或身体部位的应用。目前可用的胰岛素泵是复杂且价值上千美元的昂贵设备。该胰岛素泵的整体尺寸和重量以及输液器管的长度使得目前可用的泵送系统使用起来很麻烦。另外，由于其成本原因，目前可用的胰岛素泵的使用周期长达两年，这使得必须要进行装置的日常维护，诸如为电源重新充电以及重新填充胰岛素。
为了使上述监测及泵送系统显著微型化并进行结合，使其更加可靠、更加简易且更便宜而做的各种尝试均未取得成功。妨碍这种开发努力的限制性因素包括需要周期性替换的传感器、胰岛素供应和电池的系统需求，并且需要减少感染的风险、增加使用者的舒适度且方便使用。
发明内容
根据本发明的一些实施方式的多个方面，分析物监测和/或流体递送系统被设置为具有整合至柔性织物贴片的部件。该柔性部件可设置为佩戴在人或动物的皮肤上。在本发明的一种实施方式中，单独的贴片安装系统检测糖尿病患者的葡萄糖水平，并响应于该葡萄糖测量结果而提供合适剂量的胰岛素。根据本发明的其他方面，可提供手持式的用户界面(interface)用于无线控制该系统和/或接收来自其的信息。
在本发明的一些实施方式中，在贴片的织物中形成传导通路。可与该柔性贴片结合成一体的部件包括但不限于：电源、控制器、发送器、天线、温度传感器及其他传感器、流体泵、输液装置、电通路、开关、控制装置、电极、连接器、电阻器及其他电路元件。这些部件可以嵌入、织进或覆于柔性贴片中而不是在表面安装，或者同时也安装于表面。
柔性贴片可以由聚酯、尼龙、聚氨酯、(菜卡)或其他合成纤维或天然纤维制成。在一种实施方式中，该贴片具有弹性，该性能来自纤维本身的性能，或来自如何将纤维组合而形成贴片。柔性贴片可以是纺织的、无纺的、针织的、纺丝的或由纺织薄膜(textured film)构成，优选形成电活性织物。织物的导电性可来自精细的金属线，其在用于形成贴片的织物的纱线中或沿普通织物纤维被纺进织物中。可替换地，贴片12的电特性可来自作为涂层沉积在织物纤维上的固有导电性聚合物或纳米组分。
根据本发明的一些实施方式的多个方面，该柔性贴片可以是软的、有弹性且透气的，以便在使用中增加患者的舒适感。柔性贴片的织物可以被卷曲、折皱并折叠而不破坏其功能性。柔性贴片还可以被构造成或经涂覆而阻燃、耐水或防水。
根据本发明的一些实施方式的多个方面，柔性贴片系统的多个部分或整个系统本身可以是一次性的，例如在使用一定的预设期间之后和/或在特定的消耗品(例如供应的胰岛素)耗尽之后。例如，仅分析物传感器、输液装置以及贴装粘着物(mounting adhesive)可以是一次性的，而该柔性贴片系统的其他部分是可再用的。在这样的安排中，可以再填充胰岛素或其他流体贮器，和/或包括可拆除的药筒。电通路和/或流体泵的一部分也可以被拆卸并与新的柔性贴片一起再利用，而将用过的贴片的其余部分丢弃。可替换地，根据本发明的多个方面，柔性贴片监测及流体递送系统可以被构造为足够便宜，以便可以将整个系统处理掉并进行周期性替换。这样的安排具有降低与监测和/或流体递送系统的使用相关的安装和再发生的费用的优点。
可以使用本发明的多个方面监测各种分析物。在体液样品中，这些分析物可以包括但不限于乳酸酯、乙酰胆碱、淀粉酶、胆红素、胆固醇、绒膜促性腺激素、肌酸激酶(例如，CK-MB)、肌酸、DNA、果糖胺、葡萄糖、谷酰胺、生长激素、血细胞比容、血红蛋白(例如，HbA1c)、激素类、酮类、乳酸盐、氧、过氧化物、前列腺特异抗原、凝血酶原、RNA、促甲状腺激素、和肌钙蛋白。监测系统还可以被设置为确定药品的浓度，所述药品例如是抗生素(例如，庆大霉素、万古霉素等)、毛地黄毒苷、地高辛、滥用的药品、茶碱、华法林等。这样的分析物可在血液、间质液和其他体液中进行监测。可以递送的流体包括但不限于胰岛素及其他药剂。
附图说明
每一幅附图图解说明了本发明的多个方面。其中：
图1是示出了根据本发明的多个方面构造的柔性贴片系统的示例性实施方式的平面图；
图2是安装在患者P上的图1所示的系统的侧视图；
图3是说明了图1的系统应用于人身上的透视图。
还考虑了图中所示的本发明的各种变型。
具体实施方式
以下的描述集中于本发明的一种变型。本发明的该变型应看作是一个非限制性的实施例。应该理解，本发明并不限于所说明的一种或多种特定变型，当然是可以变化的。本发明可以进行变化，并且可以是在不违背本发明的真实精神和保护范围的前提下替代(目前已知的以及未来开发的)的等同物。另外，可以进行修改以使特定的情况、材料、物质的组合物、工艺、(一种或多种)工艺措施或(一个或多个)步骤适应于本发明的目的、精神或保护范围。
图1示出了根据本发明的一些方面构造的组合的流体递送及分析物监测系统10的示例性实施方式的俯视图，而图2示出了安装在患者P的皮肤上的系统10的仰视侧视图。该柔性织物贴片12构成了系统10的基座(base)。可以向柔性贴片12底面上提供粘结剂，以便在使用中将贴片12固定于患者的皮肤。可以将各个部件贴附于或整合至柔性贴片12中，例如电源14、控制器及发送器模块16、天线18、温度传感器20、流体泵22以及输液装置24。可以将电通路26整合于柔性贴片12中，以便使系统10的部件相互连接。
柔性贴片12可以设置有较厚的区域28，通常接近于贴片的中心，以便为安装部件提供足够的支持。在一种实施方式中，中心区域28为约1mm厚。柔性贴片12的周边区域30可做得较薄，以便促进与皮肤的贴附和粘结，特别是当皮肤移动和伸缩时。
电源14可以是一个或多个太阳能电池、一次性的或可再充电的电池或器件、从患者的分析物产生电能的电化学器件、和/或其他适合用于位于满足柔性贴片12上的部件的电能需要的电源。这种电源可以直接整合入柔性贴片12中，或可移动地插入至连接于贴片12的支持物中。电源14本身可以是柔性，即由一层或多层的纸或织物来构造电池。这样的纸或织物电池可以在电池连通时，通过将该层的一侧上的金属氧化并使氧化物在另一侧上被还原而将化学能直接转化为电能。该金属可以是锌、铝、镍或其他金属，该氧化物可以是氧化锰、或其他氧化物，且该纸或织物层可包含电解质。目前，一些公司，诸如芬兰的埃斯波的Enfucell Ltd.(www.enfucell.com)正在开发这种柔性电池。柔性贴片12本身可包括可用于形成柔性电池的一个或多个层。这样的安排可减少对电池的电连接器的需要，从而有助于使整个系统10更小、更柔软、更加贴合使用者且佩戴更舒适。
控制器和发送器16的电路可以直接整合至柔性贴片12中。可替换地，控制器和发送器16可使用传统的电子部件组装技术来构造，然后物理地并电性连接至贴片12。模块16的这种连接可以是永久的或可拆卸的。通过将模块16的电引线焊接至贴片12上的电引线可实现永久连接。模块16的可拆卸连接可通过传统的电连接器或通过具有连接模块16与贴片12的电通路的搭扣型配件32而实现。模块16优选由电源14提供电能，但可另外包括其自己的电源，或用该电源替代电源14。
天线18优选至少具有一定程度的柔性，以便使贴片12的贴合性和舒适感。天线18可以是与贴片12物理地并电性地连接的分离的元件，但优选由导电层或贴片12的层构成。天线18电连接至控制器和发送器模块16，以便由其向诸如手持式用户界面之类的外部设备发送射频(RF)信号，例如分析物读数。如果将模块16构造成也用于接收信息，则天线18可以被设置为发送并接收RF信号。另外可利用红外(IR)发射器或收发器(未示出)替代天线18或与天线18一起使用，从而使系统10与外部设备之间实现无线通信。还可以为外部通讯提供换能器线圈和/或电线连接器(未示出)，从而使用计算机来进行诊断、或上载或下载信息。
柔性贴片12可设置有一个或多个用于容纳经皮分析物传感器的传感器位置34。可同时使用多个传感器以提供多余的分析物读数。可替换地，可以一次插入一个传感器。每一个传感器用于一定预设期间(诸如每三天、五天或七天)之后，可将其拆除，并将新的传感器插入未使用的传感器位置处。优选地，贴片12的所有的传感器位置34都被使用过之后，就将贴片12从皮肤除去并将新的贴片12施加至使用者皮肤上的不同位置。可替换地，可利用新的粘结部分来再使用贴片12的部分。
可以使用自动导引器或插入器装置将经皮分析物传感器插入使用者的皮肤内，诸如在2004年7月8日公开的，公开号为20040133164的美国专利申请第10/703,214号中所描述的那些，其全文引用方式结合于本文以供参考。可利用外部导体或通过柔性贴片12的内部电通路将插入的传感器直接电连接至控制器和发送器模块16。传感器可包括粘合贴装片(adhesive mount)或一些类型的贴装特征，诸如一个或多个搭扣、钩、钳、销、夹或铸模于或连接于贴片的其他手段，以便在使用期间将传感器固定至柔性贴片12或固定至使用者的皮肤。
监测及递送系统10还可以包括用于感知室温、皮肤表面温度或皮下温度的温度传感器20。理想地，测量皮下温度更加精确地校准由分析物传感器所得的读数，因为这些读数一般是对温度敏感的。然而，皮下温度的测量可能是不现实的，因为这通常需要再一次对使用者进行皮肤穿刺。将温度传感器放置于表皮下会导致不适感并使感染机率增大。因此，可将温度传感器20安装至柔性贴片12的底面或结合成一体于柔性贴片12的底面，以测量皮肤的局部表面温度。根据该温度读数，可以估计随着传感器20的穿透深度加深，皮下温度越高。在一种实施方式中，可以利用柔性贴片12内的电通路将温度传感器20与控制器及发送器模块16相连接。
流体泵22，例如用于递送胰岛素或其他药剂，也可位于柔性贴片12上。在该示例性实施方案中，流体泵22包括可拆除的流体贮器36。贮器36可以是一次性的或可再填充的小瓶，耗尽后，该小瓶可以被另一小瓶替代。贮器36也可以是柔性的，以便其内容物排空后会像气球一样塌陷，或者其可以包括柔性隔膜部分。可替换地，贮器36可以是具有柱塞38的刚性圆筒，当该柱塞推进入贮器36中时可将流体压出。致动器40可以是步进电机、形状记忆合金致动器或其他适合用于推进柱塞38或其他使流体流出贮器36的机械装置。形状记忆合金致动器由于其尺寸小、简单且可靠所以是优选的。如果需要的话，还可以较低的制造成本以使泵22与贴片12一样是一次性的。于2004年6月17日以公开号20040115067A1公开的美国专利申请序列号10/683,659提供这样的形状记忆合金驱动泵的详情，其全部内容引用于此作为参考。贮器36并不需要是可从泵22和/或贴片12拆除的，尤其是当贴片12被设计为在流体耗尽后即除去时。
泵22优选由电源14提供电能，但可以具有其自己的电源。可使用内部传导通路26将泵22与电源14和/或控制器和发送器模块16相连接。泵22可以可拆卸地或固定地连接至贴片12。泵22或泵安装基座可通过将贴片材料的一部分夹在泵或基座与相对侧的板(plate)或(一个或多个)垫圈(washer)之间而连接至贴片12。可替换地，泵22或安装基座可利用粘结剂、紧固件或其他适合的手段而连接至贴片12。
在操作中，泵22可接收来自控制器和发送器模块16的控制信号，引起致动器40推动流体从贮器36进入输液装置24的管42，通过插管44而进入患者体内。输液装置24可包括粘合贴装片46，用于将输液装置24的远端固定至贴片12或直接固定至患者皮肤。输液装置24的近端可拆卸地连接至泵22的输出端口48。可在贴片12的薄区域30内设置多个位置50，用于可替换地放置输液装置24。可使用自动插入器或导引器将输液装置24的插管44插入患者体内。优选地，可使用单独的穿刺装置来插入插管44以及上述的经皮分析物传感器。在使用了一段预设期间(通常为3天)之后，可通过揭起(lifting)粘合贴装片46而从患者移除插管44并从泵输出端口48断开导管42从而除去输液装置24。然后可将新的输液装置24放置于另一个位置50处并连接至泵22。如图所示，将输液装置插入位置50与传感器插入位置34尽可能远地分开是有利的，以便使胰岛素或其他流体的输入的局部影响不会干扰葡萄糖监测或其他分析物测量。在一种实施方式中，输液位置50间隔约1英寸。
将系统10部件设置于柔性贴片12上，诸如控制器和发送器模块16、天线18以及泵22的部件的纵轴彼此对齐(align)。这使得整个系统在至少一个方向上呈现高度柔性。由于这些部件可能相当长并且是刚性的，图1中示出的示例性系统10沿示出的y轴比沿x轴更具柔性。在这样的安排下，当y轴与贴片12的施加位置的最急剧弯曲的方向对齐时，贴片12能够更加顺服地配合患者身体的弯曲。图3示出了这样的对齐的一个实施例，其中贴片12贴附于患者P的上臂。如图示，将更顺服的柔性贴片12的y轴水平设置而横贯手臂的弯曲，而将较不顺服的x轴沿手臂的直的纵轴而垂直设置。可将系统10粘结至人体的其他合适部位，诸如躯干、大腿或小腿。在该示例性实施方式中，系统10沿x轴为约4英寸，沿y轴为约3英寸长，且在泵22处具有最大厚度为约0.75英寸。
柔性贴片12本身可以由聚酯、尼龙、聚氨酯、
Figure G2007800394162D00101
(莱卡)或其他合成纤维或天然纤维制成。优选地，贴片12具有弹性，该性能来自纤维本身的性能，或来自如何将纤维结合而形成贴片12。贴片12可以是纺织的、无纺的、针织的、纺丝的或由纺织薄膜构成，优选形成电活性织物。织物的导电性可来自精细的金属线，或者在用于形成贴片12的织物的纱线中或沿普通织物纤维被纺进织物中。可替换地，贴片12的电特性可来自作为涂层沉积在织物纤维上的固有导电性聚合物或纳米组分。
如上文所讨论的，系统10的各个部件可被直接纺织进贴片12的织物中，包括但不限于，复杂的电通路、电路、控制装置、电极、温度传感器及其他传感器、示踪器(trace)、连接器、电阻器、天线、电池、开关及其他部件。开关和其他控制装置可以通过使用多层织物而结合到柔性贴片12中。例如，可以使用三层电活性层。两层外部导电层可包围内部电阻层，在这些层被瞬间按压在一起之前，该电阻层将导电层隔开。
使用如上所讨论的织物，柔性贴片12可以是软的、有弹性的和透气的，以便在使用中使患者感到舒适。现有的织物可提供高的水蒸汽渗透速率(MVTR)。这样的织物可以被卷曲、折皱并折叠而不破坏其功能性。如果需要，贴片12还可以被构造成或经涂覆而具备阻燃性、耐水性或防水性。
对于柔性贴片12，关于适合的织物、一般构造及部件整合方法的其他信息可以从目前正在开发的“智能织物(smart fabrics)”或“导电织物，诸如Textronics(www.textronics.com)、Konarka(www.konarka.com)、Nanosonic(www.nanosonic.com)、Eleksen(www.eleksen.com)以及Eeonyx(www.eeonyx.com)”的公司获得。例如，Eeonyx具有用于利用基于掺杂聚吡咯的固有导电性聚合物涂覆纺织品的专有工艺。该公司在原位聚合该材料-或织物自身的表面上聚合-以使该涂层材料填充了表面中的间隙，并与纤维之间形成了物理键。还参见Joseph Ogando的“Fabrics Get Smart”，Design News，2006年5月15日(www.designnews.com/article/ca6330247.html)，将其全文以引用方式结合于此以供参考。
对于有关本发明的其他细节，可根据相关领域技术人员的水平范围来使用材料及生产技术。在其他普遍地或逻辑上采用的本发明的基于方法的方面同样适用。此外，还可考虑提出所描述的发明性变型的任何可选特征并独立地要求保护，或与本文所描述的特征中的任意一个或多个相结合进行保护。同样地，参照单个项目，包括了存在多个相同项目的可能性。更具体地，如本文及所附权利要求中所用的，除非上下文中有清楚的说明，单数形式的“一个”、“一种”、“所述”以及“该”包括了多个所指物。进一步指出所撰写的权利要求排除了任何可选因素。这样，这种表述意在用作这种排他性术语如“单独地”、“仅仅”等的使用的先前基础，或用作一种“消极”限制。除非本文中有其他限定，所有的技术术语和科学术语均具有于本发明所属领域的普通技术人员的通常理解相同的含义。本发明不限于说明书所述的对象，而是仅由所附权利要求所采用的通常术语所限定。

Claims (20)

1.一种体内分析物监测系统，包括：
柔性贴片，构造为佩戴在生物体的皮肤上，所述柔性贴片包含电活性织物；
经皮分析物传感器，与所述柔性贴片结合成一体；
电源，与所述柔性贴片结合成一体；以及
控制器，与所述柔性贴片结合成一体，所述控制器由所述电源提供电能并被设置为控制所述分析物传感器。
2.根据权利要求1所述的监测系统，进一步包括与所述柔性贴片结合成一体的发送器，所述发送器由所述电源提供电能，由所述控制器控制，并被设置为从所述分析物传感器向另外的装置发送数据。
3.根据权利要求2所述的监测系统，进一步包括与所述柔性贴片结合成一体的柔性天线，所述天线用于从所述发送器发送信号。
4.根据权利要求1所述的监测系统，进一步包括与所述柔性贴片结合成一体的收发器，所述收发器由所述电源提供电能，由所述控制器控制，并被设置为从所述分析物传感器向另一装置发送数据并接收来自其他装置的信息。
5.根据权利要求4所述的监测系统，进一步包括与所述柔性贴片结合成一体的柔性天线，所述天线用于发送来自所述收发器的信号并接收来自其他装置的信号。
6.根据权利要求1所述的监测系统，其中，被测量的所述分析物为人体中的间质液葡萄糖。
7.一种流体递送系统，包括：
柔性贴片，构造为佩戴在生物体的皮肤上，所述柔性贴片包含电活性织物；
流体贮器，与所述柔性贴片相连接；
输液装置，与所述柔性贴片相连接并设置用于插入进所述生物体的皮肤内；
流体泵，与所述柔性贴片相连接并与所述贮器及输液装置流体连通，所述泵被设置为通过所述输液装置从所述贮器向所述生物体精确递送预定量的流体；
电源，与所述柔性贴片结合成一体；以及
控制器，与所述柔性贴片结合成一体，所述控制器由所述电源提供电能并设置为控制所述流体泵。
8.根据权利要求7所述的流体递送系统，进一步包括与所述柔性贴片结合成一体的发送器，所述发送器由所述电源提供电能，由所述控制器控制，并被设置为将与所述泵相关的数据发送至另外的装置。
9.根据权利要求8所述的流体递送系统，进一步包括与所述柔性贴片结合成一体的柔性天线，所述天线用于从所述发送器发送信号。
10.根据权利要求7所述的流体递送系统，进一步包括与所述柔性贴片结合成一体的收发器，所述收发器由所述电源提供电能，由所述控制器控制，并被设置为将与所述泵相关的数据发送至另外的装置，并接收来自用于控制所述泵的其他装置的信号。
11.根据权利要求10所述的流体递送系统，进一步包括与所述柔性贴片结合成一体的柔性天线，所述天线用于发送来自所述收发器的信号并接收来自其他装置的信号。
12.根据权利要求7所述的流体递送系统，其中，被泵送的所述流体是进入人体内的胰岛素。
13.一种体内分析物监测和流体递送系统，包括
柔性贴片，构造为佩戴在生物体的皮肤上，所述柔性贴片包含电活性织物；
经皮分析物传感器，与所述柔性贴片相连接；
流体贮器，与所述柔性贴片相连接；
输液装置，与所述柔性贴片相连接并设置用于插入进所述生物体的皮肤内；以及
流体泵，与所述柔性贴片相连接并与所述贮器及输液装置流体连通，所述泵设置为通过所述输液装置从所述贮器向所述生物体精确递送预定量的流体。
14.根据权利要求13所述的体内分析物监测及流体递送系统，进一步包括与所述柔性贴片结合成一体的控制器，所述控制器设置为控制所述分析物传感器及所述流体泵。
15.根据权利要求14所述的体内分析物监测及流体递送系统，进一步包括与所述柔性贴片结合成一体的电源，所述电源被设置为向所述控制器、所述流体泵及所述传感器提供电能。
16.根据权利要求13所述的体内分析物监测及流体递送系统，进一步包括与所述柔性贴片结合成一体的温度传感器，所述温度传感器被设置为测量所述生物体的温度。
17.根据权利要求13所述的体内分析物监测及流体递送系统，其中，所述柔性贴片具有较厚的中心区域以及较薄的周边区域。
18.根据权利要求13所述的体内分析物监测及流体递送系统，进一步包括整合至所述柔性贴片中的导电元件。
19.根据权利要求13所述的体内分析物监测及流体递送系统，进一步包括设置为将来自所述分析物传感器的数据发送至另外的装置的发送器。
20.根据权利要求13所述的体内分析物监测及流体递送系统，其中，所述柔性贴片包括用于容纳所述分析物传感器的多个传感器位置，且其中所述柔性贴片包括用于容纳所述输液装置的多个输注位置。
CN2007800394162A 2006-10-23 2007-10-22 用于流体递送和监测体内分析物的柔性贴片 Active CN101528282B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/552,065 US9259175B2 (en) 2006-10-23 2006-10-23 Flexible patch for fluid delivery and monitoring body analytes
US11/552,065 2006-10-23
PCT/US2007/082121 WO2008051924A2 (en) 2006-10-23 2007-10-22 Flexible patch for fluid delivery and monitoring body analytes

Publications (2)

Publication Number Publication Date
CN101528282A CN101528282A (zh) 2009-09-09
CN101528282B true CN101528282B (zh) 2013-03-20

Family

ID=39325310

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800394162A Active CN101528282B (zh) 2006-10-23 2007-10-22 用于流体递送和监测体内分析物的柔性贴片

Country Status (10)

Country Link
US (5) US9259175B2 (zh)
EP (1) EP2083878A4 (zh)
JP (2) JP2010507457A (zh)
CN (1) CN101528282B (zh)
AU (1) AU2007309070B2 (zh)
BR (1) BRPI0718065A2 (zh)
CA (1) CA2667305A1 (zh)
MX (1) MX2009004322A (zh)
RU (1) RU2481579C2 (zh)
WO (1) WO2008051924A2 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015106489A1 (zh) * 2014-01-20 2015-07-23 上海移宇科技有限公司 无导管药物流体输注器件
CN106860956A (zh) * 2017-03-17 2017-06-20 苏州艾伊帕微动力科技有限公司 一种柔性微泵驱动的慢性病便携式自动监测/给药装置
US10143396B2 (en) 2012-07-27 2018-12-04 University Of Southampton Apparatus for use for providing information on at least one muscle in a patient

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8858434B2 (en) 2004-07-13 2014-10-14 Dexcom, Inc. Transcutaneous analyte sensor
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
USD914881S1 (en) 2003-11-05 2021-03-30 Abbott Diabetes Care Inc. Analyte sensor electronic mount
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US20090082693A1 (en) * 2004-12-29 2009-03-26 Therasense, Inc. Method and apparatus for providing temperature sensor module in a data communication system
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US9259175B2 (en) * 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US20090076360A1 (en) * 2007-09-13 2009-03-19 Dexcom, Inc. Transcutaneous analyte sensor
PT1762259E (pt) 2005-09-12 2010-12-10 Unomedical As Insersor para um conjunto de infusão com uma primeira e uma segunda unidades de mola
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
CA2636034A1 (en) 2005-12-28 2007-10-25 Abbott Diabetes Care Inc. Medical device insertion
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
ES2493921T3 (es) 2006-03-14 2014-09-12 University Of Southern California Dispositivo MEMS para la administración de agentes terapéuticos
US7801582B2 (en) 2006-03-31 2010-09-21 Abbott Diabetes Care Inc. Analyte monitoring and management system and methods therefor
US8932216B2 (en) 2006-08-07 2015-01-13 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
US8206296B2 (en) 2006-08-07 2012-06-26 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
KR20090128499A (ko) 2007-03-19 2009-12-15 인슐린 메디컬 엘티디 약물 전달 장치
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
WO2008150917A1 (en) 2007-05-31 2008-12-11 Abbott Diabetes Care, Inc. Insertion devices and methods
EP3130367B1 (en) * 2007-06-25 2019-07-24 Roche Diabetes Care GmbH A system for assessing insulin sensitivity
US8641618B2 (en) 2007-06-27 2014-02-04 Abbott Diabetes Care Inc. Method and structure for securing a monitoring device element
WO2009026289A2 (en) * 2007-08-20 2009-02-26 Hmicro, Inc. Wearable user interface device, system, and method of use
WO2009029572A1 (en) * 2007-08-24 2009-03-05 Deka Products Limited Partnership Microneedle systems and apparatus
US8926509B2 (en) * 2007-08-24 2015-01-06 Hmicro, Inc. Wireless physiological sensor patches and systems
US20110019824A1 (en) * 2007-10-24 2011-01-27 Hmicro, Inc. Low power radiofrequency (rf) communication systems for secure wireless patch initialization and methods of use
WO2009055608A2 (en) 2007-10-24 2009-04-30 Hmicro, Inc. Method and apparatus to retrofit wired healthcare and fitness systems for wireless operation
JP2011504129A (ja) 2007-11-21 2011-02-03 メディンゴ・リミテッド アナライト監視及び流体分注システム
EP2231229A1 (en) 2007-12-18 2010-09-29 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US9308124B2 (en) 2007-12-20 2016-04-12 University Of Southern California Apparatus and methods for delivering therapeutic agents
BRPI0907715A2 (pt) 2008-02-13 2017-06-13 Unomedical As vedação entre uma parte de cânula e um trajeto de fluido
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
EP2898911A1 (en) 2008-05-08 2015-07-29 MiniPumps, LLC Implantable pumps and cannulas therefor
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
WO2009137785A2 (en) 2008-05-08 2009-11-12 Replenish Pumps, Llc Drug-delivery pumps and methods of manufacture
US20100069769A1 (en) * 2008-09-12 2010-03-18 Dymedix Corporation Wireless pyro/piezo sensor base station
BRPI0916125A2 (pt) 2008-11-07 2015-11-03 Insuline Medical Ltd "dispositivo de tratamento"
MX2011005735A (es) 2008-12-22 2011-06-21 Unomedical As Dispositivo medico que comprende una almohadilla de adhesivo.
CA2993719C (en) 2009-01-12 2022-04-19 Becton, Dickinson And Company Infusion set and/or patch pump having at least one of an in-dwelling rigid catheter with flexible features and/or a flexible catheter attachment
US9375529B2 (en) * 2009-09-02 2016-06-28 Becton, Dickinson And Company Extended use medical device
US20100198034A1 (en) 2009-02-03 2010-08-05 Abbott Diabetes Care Inc. Compact On-Body Physiological Monitoring Devices and Methods Thereof
US8282620B2 (en) * 2009-02-05 2012-10-09 Medtronic, Inc. Container for pump system
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
US20100331645A1 (en) * 2009-06-25 2010-12-30 Roche Diagnostics Operations, Inc. Methods and systems for wireless communication between a blood glucose meter and a portable communication device
US8613892B2 (en) 2009-06-30 2013-12-24 Abbott Diabetes Care Inc. Analyte meter with a moveable head and methods of using the same
US20110027458A1 (en) 2009-07-02 2011-02-03 Dexcom, Inc. Continuous analyte sensors and methods of making same
US8939928B2 (en) 2009-07-23 2015-01-27 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
JP2013500805A (ja) 2009-08-07 2013-01-10 ウノメディカル・アー／エス センサおよび１つまたは複数のカニューレを有する投与装置
CA2771584A1 (en) 2009-08-18 2011-02-24 Minipumps, Llc Electrolytic drug-delivery pump with adaptive control
EP3001194B1 (en) 2009-08-31 2019-04-17 Abbott Diabetes Care, Inc. Medical devices and methods
US10092691B2 (en) * 2009-09-02 2018-10-09 Becton, Dickinson And Company Flexible and conformal patch pump
EP2473226A1 (en) * 2009-09-04 2012-07-11 Minipumps LLC Adhesive skin patch with pump for subcutaneous drug delivery
EP2482724A2 (en) * 2009-09-30 2012-08-08 Dexcom, Inc. Transcutaneous analyte sensor
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
CN102639185B (zh) 2010-03-24 2015-02-04 雅培糖尿病护理公司 医疗装置插入物以及插入和使用医疗装置的方法
JP2013523233A (ja) 2010-03-30 2013-06-17 ウノメディカル アクティーゼルスカブ 医療デバイス
US20110245648A1 (en) * 2010-04-02 2011-10-06 Hudson Stanford P Biosensor Remote Collection Packaging System with Bioinformatics Processing
US8888720B2 (en) 2010-04-02 2014-11-18 Stanford P. Hudson Great toe dorsiflexion detection
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US9017255B2 (en) 2010-07-27 2015-04-28 Carefusion 303, Inc. System and method for saving battery power in a patient monitoring system
US9420952B2 (en) 2010-07-27 2016-08-23 Carefusion 303, Inc. Temperature probe suitable for axillary reading
US9055925B2 (en) 2010-07-27 2015-06-16 Carefusion 303, Inc. System and method for reducing false alarms associated with vital-signs monitoring
US9615792B2 (en) 2010-07-27 2017-04-11 Carefusion 303, Inc. System and method for conserving battery power in a patient monitoring system
US8814792B2 (en) 2010-07-27 2014-08-26 Carefusion 303, Inc. System and method for storing and forwarding data from a vital-signs monitor
US9585620B2 (en) * 2010-07-27 2017-03-07 Carefusion 303, Inc. Vital-signs patch having a flexible attachment to electrodes
US9357929B2 (en) 2010-07-27 2016-06-07 Carefusion 303, Inc. System and method for monitoring body temperature of a person
EP2433663A1 (en) 2010-09-27 2012-03-28 Unomedical A/S Insertion system
EP2436412A1 (en) 2010-10-04 2012-04-04 Unomedical A/S A sprinkler cannula
EP2438938A1 (en) * 2010-10-11 2012-04-11 PharmaSens AG Syringe type pump
US8579872B2 (en) * 2010-10-27 2013-11-12 Kci Licensing, Inc. Reduced-pressure systems, dressings, and methods employing a wireless pump
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
US9950109B2 (en) 2010-11-30 2018-04-24 Becton, Dickinson And Company Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion
US8814831B2 (en) 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
US20130338598A1 (en) * 2011-02-09 2013-12-19 Unomedical A/S Removal of Cannula Part from Base Part
WO2012123274A1 (en) 2011-03-14 2012-09-20 Unomedical A/S Inserter system with transport protection
WO2012164556A1 (en) * 2011-05-30 2012-12-06 Insuline Medical Ltd Drug delivery infusion set with manual pump
US9974472B2 (en) 2011-06-16 2018-05-22 Abbott Diabetes Care Inc. Temperature-compensated analyte monitoring devices, systems, and methods thereof
DE102011081555A1 (de) * 2011-08-25 2013-02-28 Robert Bosch Gmbh Elektrisches Funktionspflaster
CN103957962B (zh) 2011-10-05 2017-07-07 犹诺医药有限公司 用于同时插入多个经皮部分的插入物
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
JP6193256B2 (ja) * 2011-12-07 2017-09-06 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ リリース可能な流体コネクタ付の点滴装置
EP4344633A2 (en) 2011-12-11 2024-04-03 Abbott Diabetes Care, Inc. Analyte sensor methods
US10010274B2 (en) * 2011-12-16 2018-07-03 James Winkelman Systems, devices and methods for in situ calibration of implantable sensors
EP3682871A1 (en) * 2012-03-05 2020-07-22 Becton, Dickinson and Company Apparatus for adhesive removal
DE102012203880A1 (de) * 2012-03-13 2013-09-19 Robert Bosch Gmbh Funktionspflaster mit Sensor und Aktor
US10286129B2 (en) * 2012-03-28 2019-05-14 Kci Licensing, Inc. Reduced-pressure systems, dressings, and methods facilitating separation of electronic and clinical component parts
DE202012005321U1 (de) * 2012-05-31 2013-09-03 Applied Biomedcial Systems Bv Diagnosepflaster mit textiler Grundlage zur Verbindung mit Elektronik
CN104768591B (zh) * 2012-08-13 2018-08-17 Tg米德外斯有限公司 物质输送装置
WO2014050065A1 (ja) * 2012-09-26 2014-04-03 テルモ株式会社 薬液投与装置
US20140213866A1 (en) 2012-10-12 2014-07-31 Dexcom, Inc. Sensors for continuous analyte monitoring, and related methods
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
EP2972264A4 (en) 2013-03-14 2016-12-07 Sano Intelligence Inc ON THE BODY BORN MICROSENSOR FOR BIO SURVEILLANCE
CN105339023A (zh) * 2013-03-15 2016-02-17 普迈针药物公司 用于经皮递送化合物的设备、系统和方法
US9494474B2 (en) * 2013-04-03 2016-11-15 Texavie Technologies Inc. Core-shell nanofiber textiles for strain sensing, and methods of their manufacture
US9867953B2 (en) 2013-06-21 2018-01-16 Tandem Diabetes Care, Inc. System and method for infusion set dislodgement detection
EP3701858A1 (en) * 2013-07-01 2020-09-02 Mayo Foundation for Medical Education and Research Advanced health monitoring system
WO2015009970A1 (en) 2013-07-18 2015-01-22 Erythron Llc Spectroscopic measurements with parallel array detector
WO2015021031A1 (en) 2013-08-05 2015-02-12 Cam Med Llc Conformable patch pump
KR102193134B1 (ko) 2013-10-14 2020-12-21 삼성전자주식회사 착용형 인체 감지 장치와 이를 포함하는 시스템
WO2015102745A1 (en) 2013-12-31 2015-07-09 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
EP3094250B1 (en) 2014-01-13 2020-01-01 Senseonics, Incorporated A remotely powered, multisite sensing system with a shared, two-wire bus for power and communication
US10872048B2 (en) 2014-01-13 2020-12-22 Senseonics, Incorporated Remotely-powered sensing system with multiple sensing devices
WO2015131151A2 (en) 2014-02-28 2015-09-03 Erythron, Llc Method and apparatus for determining markers of health by analysis of blood
US20150257685A1 (en) 2014-03-13 2015-09-17 Sano Intelligence, Inc. System for monitoring body chemistry
US10595754B2 (en) 2014-03-13 2020-03-24 Sano Intelligence, Inc. System for monitoring body chemistry
US20150289788A1 (en) 2014-04-10 2015-10-15 Dexcom, Inc. Sensors for continuous analyte monitoring, and related methods
US10004845B2 (en) 2014-04-18 2018-06-26 Becton, Dickinson And Company Split piston metering pump
DE202015010002U1 (de) 2014-05-21 2022-12-12 Abbott Diabetes Care, Inc. Management mehrerer Vorrichtungen innerhalb einer Analytüberwachungsumgebung
CN104055484B (zh) * 2014-06-11 2016-12-07 杨松 传感器支撑体和采集人体生理信号的装置
US9416775B2 (en) 2014-07-02 2016-08-16 Becton, Dickinson And Company Internal cam metering pump
US11464899B2 (en) 2014-08-28 2022-10-11 Becton, Dickinson And Company Wireless communication for on-body medical devices
US10945663B2 (en) 2014-11-04 2021-03-16 North Carolina State University Smart sensing systems and related methods
US10642960B2 (en) * 2014-12-22 2020-05-05 Koninklijke Philips N.V. Wearable kit with smart patch
US10201295B2 (en) * 2015-03-13 2019-02-12 Verily Life Sciences Llc User interactions for a bandage type monitoring device
WO2016168090A1 (en) 2015-04-14 2016-10-20 Nueon, Inc. Method and apparatus for determining markers of health by analysis of blood
WO2016183493A1 (en) 2015-05-14 2016-11-17 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
US10765353B2 (en) * 2015-07-02 2020-09-08 Verily Life Sciences Llc Calibration methods for a bandage-type analyte sensor
KR20170058524A (ko) * 2015-11-19 2017-05-29 전자부품연구원 스마트 밴드용 유연기판 모듈
EP3405230A1 (en) 2016-01-19 2018-11-28 Unomedical A/S Cannula and infusion devices
ES2952014T3 (es) 2016-02-05 2023-10-26 Hoffmann La Roche Dispositivo médico para detectar al menos un analito en un líquido corporal
HUE062012T2 (hu) 2016-02-05 2023-09-28 Hoffmann La Roche Orvostechnikai eszköz legalább egy analit kimutatására testfolyadékban
WO2017165403A1 (en) 2016-03-21 2017-09-28 Nueon Inc. Porous mesh spectrometry methods and apparatus
US10888281B2 (en) * 2016-05-13 2021-01-12 PercuSense, Inc. System and method for disease risk assessment and treatment
US10561788B2 (en) * 2016-10-06 2020-02-18 Medtronic Minimed, Inc. Infusion systems and methods for automated exercise mitigation
WO2018085699A1 (en) 2016-11-04 2018-05-11 Nueon Inc. Combination blood lancet and analyzer
CN107029343B (zh) * 2017-01-18 2018-11-23 常州华佳医疗器械有限公司 一种便捷式透皮给药贴片器械及其制备方法
CN110461217B (zh) 2017-01-23 2022-09-16 雅培糖尿病护理公司 用于分析物传感器插入的系统、装置和方法
US20200275865A1 (en) * 2017-03-17 2020-09-03 Samsung Electronics Co., Ltd. Electronic device and control method therefor
CN106821395A (zh) * 2017-03-23 2017-06-13 刘慧� 一种预测血糖的系统
EP3606427A1 (en) 2017-04-04 2020-02-12 Roche Diabetes Care GmbH Medical sensor system, in particular continuous glucose monitoring system
RU2745731C1 (ru) 2017-04-04 2021-03-31 Ф. Хоффманн-Ля Рош Аг Носимое на теле медицинское устройство
CN110741248B (zh) 2017-06-11 2023-05-30 亿皮米特瑞克斯公司 基于芯片的多通道电化学转换器及其使用方法
EP3700408A1 (en) * 2017-10-25 2020-09-02 Skindicator AB A device and a method for detection of changes in tissue
CA3089212A1 (en) * 2018-01-23 2019-08-01 Dexcom, Inc. Systems, devices, and methods to compensate for temperature effects on sensors
US10849557B2 (en) 2018-03-28 2020-12-01 Apple Inc. Fabric-based items with stretchable bands
US20190307372A1 (en) * 2018-04-10 2019-10-10 Cesar A. Ocampo Battery-less sweat patch to measure biochemical composition
CN110755088B (zh) * 2018-07-27 2022-07-26 华广生技股份有限公司 弹性生理贴片
US10736037B2 (en) 2018-12-26 2020-08-04 Tandem Diabetes Care, Inc. Methods of wireless communication in an infusion pump system
CN109513059B (zh) * 2019-01-28 2021-03-23 重庆医科大学附属永川医院 一种带恒温和混匀功能的胰岛素笔存储装置
US11464908B2 (en) 2019-02-18 2022-10-11 Tandem Diabetes Care, Inc. Methods and apparatus for monitoring infusion sites for ambulatory infusion pumps
WO2020219127A1 (en) * 2019-04-23 2020-10-29 Synolus Medical, Inc. Wearable injector
CN110115800A (zh) * 2019-05-17 2019-08-13 清华大学 基于超声波供能的柔性药物释放微系统
WO2020236796A1 (en) 2019-05-20 2020-11-26 Unomedical A/S Rotatable infusion device and methods thereof
USD1002852S1 (en) 2019-06-06 2023-10-24 Abbott Diabetes Care Inc. Analyte sensor device
WO2020257069A1 (en) * 2019-06-17 2020-12-24 Biolinq, Inc. Mechanical coupling of an analyte-selective sensor and an infusion system
WO2021157654A1 (ja) * 2020-02-07 2021-08-12 テルモ株式会社 薬剤投与装置
CN115916292A (zh) * 2020-05-20 2023-04-04 赛诺菲 可穿戴注射装置
EP4048152B1 (en) 2020-07-29 2023-12-20 Biolinq Incorporated Continuous analyte monitoring system with microneedle array
CN112023191B (zh) * 2020-09-14 2021-03-12 广州大麦生物科技有限公司 一种生物电子设备
USD999913S1 (en) 2020-12-21 2023-09-26 Abbott Diabetes Care Inc Analyte sensor inserter
US20240115799A1 (en) * 2021-01-05 2024-04-11 Medtrum Technologies Inc. Skin patch drug infusion device
CN113125524B (zh) * 2021-04-19 2023-01-20 上海交通大学 单层网式丝网传感器
USD988882S1 (en) 2021-04-21 2023-06-13 Informed Data Systems Inc. Sensor assembly
US11857344B2 (en) 2021-05-08 2024-01-02 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
WO2024010974A1 (en) * 2022-07-08 2024-01-11 Tandem Diabetes Care, Inc. Insulin pump with integrated continuous glucose monitor
TWI824719B (zh) * 2022-09-15 2023-12-01 華廣生技股份有限公司 生理訊號監測裝置及增加生理訊號監測裝置之黏貼力的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948006A (en) * 1998-10-14 1999-09-07 Advanced Bionics Corporation Transcutaneous transmission patch
US5957854A (en) * 1993-09-04 1999-09-28 Besson; Marcus Wireless medical diagnosis and monitoring equipment
US6560471B1 (en) * 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
CN1499949A (zh) * 2000-12-19 2004-05-26 ����˹ҽ�����޹�˾ 分析物测量

Family Cites Families (777)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123790A (en) 1964-03-03 tyler
US3211001A (en) 1961-08-01 1965-10-12 Barber Colman Co Temperature sensing device
US3260656A (en) 1962-09-27 1966-07-12 Corning Glass Works Method and apparatus for electrolytically determining a species in a fluid
GB1191363A (en) 1968-02-19 1970-05-13 Pavelle Ltd Improvements in or relating to Electronic Thermostats.
US3653841A (en) 1969-12-19 1972-04-04 Hoffmann La Roche Methods and compositions for determining glucose in blood
US3776832A (en) 1970-11-10 1973-12-04 Energetics Science Electrochemical detection cell
US3719564A (en) 1971-05-10 1973-03-06 Philip Morris Inc Method of determining a reducible gas concentration and sensor therefor
US3837339A (en) 1972-02-03 1974-09-24 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
US3949388A (en) 1972-11-13 1976-04-06 Monitron Industries, Inc. Physiological sensor and transmitter
US3908657A (en) 1973-01-15 1975-09-30 Univ Johns Hopkins System for continuous withdrawal of blood
US4100048A (en) 1973-09-20 1978-07-11 U.S. Philips Corporation Polarographic cell
US3926760A (en) 1973-09-28 1975-12-16 Du Pont Process for electrophoretic deposition of polymer
US3972320A (en) 1974-08-12 1976-08-03 Gabor Ujhelyi Kalman Patient monitoring system
US4245634A (en) 1975-01-22 1981-01-20 Hospital For Sick Children Artificial beta cell
US4036749A (en) 1975-04-30 1977-07-19 Anderson Donald R Purification of saline water
US3979274A (en) 1975-09-24 1976-09-07 The Yellow Springs Instrument Company, Inc. Membrane for enzyme electrodes
DE2645048A1 (de) 1975-10-08 1977-04-21 Gen Electric Einpflanzbarer elektrochemischer sensor
US4016866A (en) 1975-12-18 1977-04-12 General Electric Company Implantable electrochemical sensor
US4055175A (en) 1976-05-07 1977-10-25 Miles Laboratories, Inc. Blood glucose control apparatus
DE2625834B2 (de) 1976-06-09 1978-10-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Bestimmung von Substraten oder Enzymaktivitäten
US4059406A (en) 1976-07-12 1977-11-22 E D T Supplies Limited Electrochemical detector system
US4076596A (en) 1976-10-07 1978-02-28 Leeds & Northrup Company Apparatus for electrolytically determining a species in a fluid and method of use
US4129128A (en) 1977-02-23 1978-12-12 Mcfarlane Richard H Securing device for catheter placement assembly
FR2387659A1 (fr) 1977-04-21 1978-11-17 Armines Dispositif de controle et regulation de la glycemie
US4098574A (en) 1977-08-01 1978-07-04 Eastman Kodak Company Glucose detection system free from fluoride-ion interference
US4178916A (en) 1977-09-26 1979-12-18 Mcnamara Elger W Diabetic insulin alarm system
JPS5912135B2 (ja) 1977-09-28 1984-03-21 松下電器産業株式会社 酵素電極
US4151845A (en) 1977-11-25 1979-05-01 Miles Laboratories, Inc. Blood glucose control apparatus
DK151000C (da) 1978-02-17 1988-06-13 Radiometer As Fremgangsmaade og apparat til bestemmelse af en patients in vivo plasma-ph-vaerdi
FR2420331A1 (fr) 1978-03-23 1979-10-19 Claude Bernard Tete de mesure combinee, destinee a etre mise en place sur ou dans des parties corporelles, permettant l'obtention simultanee de signaux de mesure relatifs a une activite electrique d'une part et a une activite ionique d'autre part
US4172770A (en) 1978-03-27 1979-10-30 Technicon Instruments Corporation Flow-through electrochemical system analytical method
DE2817363C2 (de) 1978-04-20 1984-01-26 Siemens AG, 1000 Berlin und 8000 München Verfahren zur Konzentrationsbestimmung von Zucker und dafür geeigneter elektrokatalytischer Zuckersensor
US4344438A (en) 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
HU177369B (en) 1978-09-08 1981-09-28 Radelkis Electrokemiai Industrial molecule-selective sensing device and method for producing same
US4240438A (en) 1978-10-02 1980-12-23 Wisconsin Alumni Research Foundation Method for monitoring blood glucose levels and elements
AU530979B2 (en) 1978-12-07 1983-08-04 Aus. Training Aids Pty. Ltd., Detecting position of bullet fired at target
US4247297A (en) 1979-02-23 1981-01-27 Miles Laboratories, Inc. Test means and method for interference resistant determination of oxidizing substances
US4573994A (en) 1979-04-27 1986-03-04 The Johns Hopkins University Refillable medication infusion apparatus
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4365637A (en) 1979-07-05 1982-12-28 Dia-Med, Inc. Perspiration indicating alarm for diabetics
CS210174B1 (en) 1979-07-12 1982-01-29 Ivan Emmer Method of making the electric hygrometric sensor
US4458686A (en) 1979-08-02 1984-07-10 Children's Hospital Medical Center Cutaneous methods of measuring body substances
US4401122A (en) 1979-08-02 1983-08-30 Children's Hospital Medical Center Cutaneous methods of measuring body substances
US4450842A (en) 1980-04-25 1984-05-29 Cordis Corporation Solid state reference electrode
US4340458A (en) 1980-06-02 1982-07-20 Joslin Diabetes Center, Inc. Glucose sensor
US4404066A (en) 1980-08-25 1983-09-13 The Yellow Springs Instrument Company Method for quantitatively determining a particular substrate catalyzed by a multisubstrate enzyme
US4356074A (en) 1980-08-25 1982-10-26 The Yellow Springs Instrument Company, Inc. Substrate specific galactose oxidase enzyme electrodes
USRE32947E (en) 1980-09-30 1989-06-13 Baptist Medical Center Of Oklahoma, Inc. Magnetic transcutaneous mount for external device of an associated implant
US4352960A (en) 1980-09-30 1982-10-05 Baptist Medical Center Of Oklahoma, Inc. Magnetic transcutaneous mount for external device of an associated implant
US4425920A (en) 1980-10-24 1984-01-17 Purdue Research Foundation Apparatus and method for measurement and control of blood pressure
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4390621A (en) 1980-12-15 1983-06-28 Miles Laboratories, Inc. Method and device for detecting glucose concentration
US4436094A (en) 1981-03-09 1984-03-13 Evreka, Inc. Monitor for continuous in vivo measurement of glucose concentration
AT369254B (de) 1981-05-07 1982-12-27 Otto Dipl Ing Dr Tech Prohaska Medizinische sonde
FR2508305B1 (fr) 1981-06-25 1986-04-11 Slama Gerard Dispositif pour provoquer une petite piqure en vue de recueillir une goutte de sang
US4440175A (en) 1981-08-10 1984-04-03 University Patents, Inc. Membrane electrode for non-ionic species
DE3138194A1 (de) 1981-09-25 1983-04-14 Basf Ag, 6700 Ludwigshafen Wasserunloesliches poroeses proteinmaterial, dessen herstellung und verwendung
DE3278334D1 (en) 1981-10-23 1988-05-19 Genetics Int Inc Sensor for components of a liquid mixture
US4431004A (en) 1981-10-27 1984-02-14 Bessman Samuel P Implantable glucose sensor
US4418148A (en) 1981-11-05 1983-11-29 Miles Laboratories, Inc. Multilayer enzyme electrode membrane
US4494950A (en) 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
JPS58153154A (ja) 1982-03-09 1983-09-12 Ajinomoto Co Inc 修飾電極
US4581336A (en) 1982-04-26 1986-04-08 Uop Inc. Surface-modified electrodes
FI831399L (fi) 1982-04-29 1983-10-30 Agripat Sa Kontaktlins av haerdad polyvinylalkohol
DE3221339A1 (de) 1982-06-05 1983-12-08 Basf Ag, 6700 Ludwigshafen Verfahren zur elektrochemischen hydrierung von nicotinamidadenin-dinucleotid
US4427770A (en) 1982-06-14 1984-01-24 Miles Laboratories, Inc. High glucose-determining analytical element
US4509531A (en) 1982-07-28 1985-04-09 Teledyne Industries, Inc. Personal physiological monitor
US4534356A (en) 1982-07-30 1985-08-13 Diamond Shamrock Chemicals Company Solid state transcutaneous blood gas sensors
DE3228551A1 (de) 1982-07-30 1984-02-02 Siemens AG, 1000 Berlin und 8000 München Verfahren zur bestimmung der zuckerkonzentration
US4571292A (en) 1982-08-12 1986-02-18 Case Western Reserve University Apparatus for electrochemical measurements
US4552840A (en) 1982-12-02 1985-11-12 California And Hawaiian Sugar Company Enzyme electrode and method for dextran analysis
US4527240A (en) 1982-12-29 1985-07-02 Kvitash Vadim I Balascopy method for detecting and rapidly evaluating multiple imbalances within multi-parametric systems
US4461691A (en) 1983-02-10 1984-07-24 The United States Of America As Represented By The United States Department Of Energy Organic conductive films for semiconductor electrodes
US4679562A (en) 1983-02-16 1987-07-14 Cardiac Pacemakers, Inc. Glucose sensor
IT1170375B (it) 1983-04-19 1987-06-03 Giuseppe Bombardieri Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazioni di glucosio ottenute senza bisogno di prelievi del sangue del paziente
CA1219040A (en) 1983-05-05 1987-03-10 Elliot V. Plotkin Measurement of enzyme-catalysed reactions
CA1218704A (en) 1983-05-05 1987-03-03 Graham Davis Assay systems using more than one enzyme
US5682884A (en) 1983-05-05 1997-11-04 Medisense, Inc. Strip electrode with screen printing
US5509410A (en) 1983-06-06 1996-04-23 Medisense, Inc. Strip electrode including screen printing of a single layer
US4484987A (en) 1983-05-19 1984-11-27 The Regents Of The University Of California Method and membrane applicable to implantable sensor
US4650547A (en) 1983-05-19 1987-03-17 The Regents Of The University Of California Method and membrane applicable to implantable sensor
US4524114A (en) 1983-07-05 1985-06-18 Allied Corporation Bifunctional air electrode
US4538616A (en) 1983-07-25 1985-09-03 Robert Rogoff Blood sugar level sensing and monitoring transducer
US4655880A (en) 1983-08-01 1987-04-07 Case Western Reserve University Apparatus and method for sensing species, substances and substrates using oxidase
US4543955A (en) 1983-08-01 1985-10-01 Cordis Corporation System for controlling body implantable action device
SE8305704D0 (sv) 1983-10-18 1983-10-18 Leo Ab Cuvette
US4560534A (en) 1983-11-02 1985-12-24 Miles Laboratories, Inc. Polymer catalyst transducers
US4522690A (en) 1983-12-01 1985-06-11 Honeywell Inc. Electrochemical sensing of carbon monoxide
US6017335A (en) 1983-12-12 2000-01-25 Burnham; Warren R. Method for making a tubular product, especially a catheter, and article made thereby
WO1985002627A1 (en) 1983-12-16 1985-06-20 Genetics International, Inc. Assay for nucleic acids
WO1985005119A1 (fr) 1984-04-30 1985-11-21 Stiftung, R., E. Procede de sensibilisation d'un photo-catalyseur d'oxydo-reduction et photo-catalyseur ainsi obtenu
US5141868A (en) 1984-06-13 1992-08-25 Internationale Octrooi Maatschappij "Octropa" Bv Device for use in chemical test procedures
DK8601218A (zh) 1984-07-18 1986-03-17
DE3429596A1 (de) 1984-08-10 1986-02-20 Siemens AG, 1000 Berlin und 8000 München Vorrichtung zur physiologischen frequenzsteuerung eines mit einer reizelektrode versehenen herzschrittmachers
US4820399A (en) 1984-08-31 1989-04-11 Shimadzu Corporation Enzyme electrodes
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
JPS61111428A (ja) 1984-11-06 1986-05-29 Terumo Corp 電子体温計
US4721601A (en) 1984-11-23 1988-01-26 Massachusetts Institute Of Technology Molecule-based microelectronic devices
US4717673A (en) 1984-11-23 1988-01-05 Massachusetts Institute Of Technology Microelectrochemical devices
JPH0617889B2 (ja) 1984-11-27 1994-03-09 株式会社日立製作所 生物化学センサ
EP0186210B1 (en) 1984-12-28 1992-04-22 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Ion sensor
GB8500729D0 (en) 1985-01-11 1985-02-13 Hill H A O Surface-modified electrode
DE3502913C1 (de) 1985-01-29 1986-07-03 Günter Prof. Dr.rer.nat. 5100 Aachen Rau Messaufnehmer zur nichtinvasiven Erfassung elektrophysiologischer Groessen
AU5481786A (en) 1985-03-20 1986-09-25 Hochmair, E.S. Transcutaneous power and signal transmission system
US5279294A (en) 1985-04-08 1994-01-18 Cascade Medical, Inc. Medical diagnostic system
US4627445A (en) 1985-04-08 1986-12-09 Garid, Inc. Glucose medical monitoring system
US4781798A (en) 1985-04-19 1988-11-01 The Regents Of The University Of California Transparent multi-oxygen sensor array and method of using same
US4671288A (en) 1985-06-13 1987-06-09 The Regents Of The University Of California Electrochemical cell sensor for continuous short-term use in tissues and blood
EP0230472B2 (en) 1985-06-21 2000-12-13 Matsushita Electric Industrial Co., Ltd. Biosensor and method of manufacturing same
US4938860A (en) 1985-06-28 1990-07-03 Miles Inc. Electrode for electrochemical sensors
US4796634A (en) 1985-08-09 1989-01-10 Lawrence Medical Systems, Inc. Methods and apparatus for monitoring cardiac output
US4805624A (en) 1985-09-09 1989-02-21 The Montefiore Hospital Association Of Western Pa Low-potential electrochemical redox sensors
US4680268A (en) 1985-09-18 1987-07-14 Children's Hospital Medical Center Implantable gas-containing biosensor and method for measuring an analyte such as glucose
US4890620A (en) 1985-09-20 1990-01-02 The Regents Of The University Of California Two-dimensional diffusion glucose substrate sensing electrode
US4627908A (en) 1985-10-24 1986-12-09 Chevron Research Company Process for stabilizing lube base stocks derived from bright stock
CA1254616A (en) 1985-11-11 1989-05-23 Calum J. Mcneil Electrochemical enzymic assay procedures
GB8529300D0 (en) 1985-11-28 1986-01-02 Ici Plc Membrane
US4755173A (en) 1986-02-25 1988-07-05 Pacesetter Infusion, Ltd. Soft cannula subcutaneous injection set
US4776944A (en) 1986-03-20 1988-10-11 Jiri Janata Chemical selective sensors utilizing admittance modulated membranes
US4685463A (en) 1986-04-03 1987-08-11 Williams R Bruce Device for continuous in vivo measurement of blood glucose concentrations
US4726378A (en) 1986-04-11 1988-02-23 Minnesota Mining And Manufacturing Company Adjustable magnetic supercutaneous device and transcutaneous coupling apparatus
US4757022A (en) 1986-04-15 1988-07-12 Markwell Medical Institute, Inc. Biological fluid measuring device
US4994167A (en) 1986-04-15 1991-02-19 Markwell Medical Institute, Inc. Biological fluid measuring device
US4711247A (en) 1986-04-18 1987-12-08 Henry Fishman Allergy testing method and apparatus
US4909908A (en) 1986-04-24 1990-03-20 Pepi Ross Electrochemical cncentration detector method
DE3614821A1 (de) 1986-05-02 1987-11-05 Siemens Ag Implantierbare, eichbare messvorrichtung fuer eine koerpersubstanz sowie eichverfahren
US4703756A (en) 1986-05-06 1987-11-03 The Regents Of The University Of California Complete glucose monitoring system with an implantable, telemetered sensor module
US4731726A (en) 1986-05-19 1988-03-15 Healthware Corporation Patient-operated glucose monitor and diabetes management system
GB8612861D0 (en) 1986-05-27 1986-07-02 Cambridge Life Sciences Immobilised enzyme biosensors
US4969468A (en) 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US4911794A (en) 1986-06-20 1990-03-27 Molecular Devices Corporation Measuring with zero volume cell
US5001054A (en) 1986-06-26 1991-03-19 Becton, Dickinson And Company Method for monitoring glucose
JPS636451A (ja) 1986-06-27 1988-01-12 Terumo Corp 酵素センサ
US4764416A (en) 1986-07-01 1988-08-16 Mitsubishi Denki Kabushiki Kaisha Electric element circuit using oxidation-reduction substances
US4917800A (en) 1986-07-07 1990-04-17 Bend Research, Inc. Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers
US4784736A (en) 1986-07-07 1988-11-15 Bend Research, Inc. Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers
US4726716A (en) 1986-07-21 1988-02-23 Mcguire Thomas V Fastener for catheter
US4894137A (en) 1986-09-12 1990-01-16 Omron Tateisi Electronics Co. Enzyme electrode
US5055171A (en) 1986-10-06 1991-10-08 T And G Corporation Ionic semiconductor materials and applications thereof
US4865038A (en) 1986-10-09 1989-09-12 Novametrix Medical Systems, Inc. Sensor appliance for non-invasive monitoring
US4897162A (en) 1986-11-14 1990-01-30 The Cleveland Clinic Foundation Pulse voltammetry
DE3700119A1 (de) 1987-01-03 1988-07-14 Inst Diabetestechnologie Gemei Implantierbarer elektrochemischer sensor
US4934369A (en) 1987-01-30 1990-06-19 Minnesota Mining And Manufacturing Company Intravascular blood parameter measurement system
GB2201248B (en) 1987-02-24 1991-04-17 Ici Plc Enzyme electrode sensors
US4777953A (en) 1987-02-25 1988-10-18 Ash Medical Systems, Inc. Capillary filtration and collection method for long-term monitoring of blood constituents
US5002054A (en) 1987-02-25 1991-03-26 Ash Medical Systems, Inc. Interstitial filtration and collection device and method for long-term monitoring of physiological constituents of the body
US4854322A (en) 1987-02-25 1989-08-08 Ash Medical Systems, Inc. Capillary filtration and collection device for long-term monitoring of blood constituents
US4848351A (en) 1987-03-04 1989-07-18 Sentry Medical Products, Inc. Medical electrode assembly
US4923586A (en) 1987-03-31 1990-05-08 Daikin Industries, Ltd. Enzyme electrode unit
US4935345A (en) 1987-04-07 1990-06-19 Arizona Board Of Regents Implantable microelectronic biochemical sensor incorporating thin film thermopile
US4759828A (en) 1987-04-09 1988-07-26 Nova Biomedical Corporation Glucose electrode and method of determining glucose
US5352348A (en) 1987-04-09 1994-10-04 Nova Biomedical Corporation Method of using enzyme electrode
US4749985A (en) 1987-04-13 1988-06-07 United States Of America As Represented By The United States Department Of Energy Functional relationship-based alarm processing
US4781683A (en) 1987-04-22 1988-11-01 The Johns Hopkins University Single-use, self-annulling injection syringe
EP0290683A3 (en) 1987-05-01 1988-12-14 Diva Medical Systems B.V. Diabetes management system and apparatus
US5286364A (en) 1987-06-08 1994-02-15 Rutgers University Surface-modified electochemical biosensor
US4822337A (en) 1987-06-22 1989-04-18 Stanley Newhouse Insulin delivery method and apparatus
JPH07122624B2 (ja) 1987-07-06 1995-12-25 ダイキン工業株式会社 バイオセンサ
US4874500A (en) 1987-07-15 1989-10-17 Sri International Microelectrochemical sensor and sensor array
GB8718430D0 (en) 1987-08-04 1987-09-09 Ici Plc Sensor
JPS6423155A (en) 1987-07-17 1989-01-25 Daikin Ind Ltd Electrode refreshing device for biosensor
EP0378683B1 (en) 1987-08-11 1995-11-02 Terumo Kabushiki Kaisha Automatic sphygmomanometer
US4974929A (en) 1987-09-22 1990-12-04 Baxter International, Inc. Fiber optical probe connector for physiologic measurement devices
NL8702370A (nl) 1987-10-05 1989-05-01 Groningen Science Park Werkwijze en stelsel voor glucosebepaling en daarvoor bruikbaar meetcelsamenstel.
US4815469A (en) 1987-10-08 1989-03-28 Siemens-Pacesetter, Inc. Implantable blood oxygen sensor and method of use
JPH01140054A (ja) 1987-11-26 1989-06-01 Nec Corp グルコースセンサ
US4813424A (en) 1987-12-23 1989-03-21 University Of New Mexico Long-life membrane electrode for non-ionic species
US5108564A (en) 1988-03-15 1992-04-28 Tall Oak Ventures Method and apparatus for amperometric diagnostic analysis
WO1989009397A1 (en) 1988-03-31 1989-10-05 Matsushita Electric Industrial Co., Ltd. Biosensor and process for its production
GB8817421D0 (en) 1988-07-21 1988-08-24 Medisense Inc Bioelectrochemical electrodes
US4954129A (en) 1988-07-25 1990-09-04 Abbott Laboratories Hydrodynamic clot flushing
US4925268A (en) 1988-07-25 1990-05-15 Abbott Laboratories Fiber-optic physiological probes
EP0353328A1 (en) 1988-08-03 1990-02-07 Dräger Nederland B.V. A polarographic-amperometric three-electrode sensor
US5340722A (en) 1988-08-24 1994-08-23 Avl Medical Instruments Ag Method for the determination of the concentration of an enzyme substrate and a sensor for carrying out the method
US5264106A (en) 1988-10-07 1993-11-23 Medisense, Inc. Enhanced amperometric sensor
US4995402A (en) 1988-10-12 1991-02-26 Thorne, Smith, Astill Technologies, Inc. Medical droplet whole blood and like monitoring
US4895147A (en) 1988-10-28 1990-01-23 Sherwood Medical Company Lancet injector
US5360404A (en) 1988-12-14 1994-11-01 Inviro Medical Devices Ltd. Needle guard and needle assembly for syringe
EP0384504A1 (en) 1989-02-24 1990-08-29 Duphar International Research B.V Detection strip for detecting and identifying chemical air contaminants, and portable detection kit comprising said strips
EP0385805B1 (en) 1989-03-03 1996-06-05 Edward W. Stark Signal processing method and apparatus
US5205920A (en) 1989-03-03 1993-04-27 Noboru Oyama Enzyme sensor and method of manufacturing the same
US5089112A (en) 1989-03-20 1992-02-18 Associated Universities, Inc. Electrochemical biosensor based on immobilized enzymes and redox polymers
US4953552A (en) 1989-04-21 1990-09-04 Demarzo Arthur P Blood glucose monitoring system
US4988341A (en) 1989-06-05 1991-01-29 Eastman Kodak Company Sterilizing dressing device and method for skin puncture
US5198367A (en) 1989-06-09 1993-03-30 Masuo Aizawa Homogeneous amperometric immunoassay
FR2648353B1 (fr) 1989-06-16 1992-03-27 Europhor Sa Sonde de microdialyse
CH677149A5 (zh) 1989-07-07 1991-04-15 Disetronic Ag
US5431160A (en) 1989-07-19 1995-07-11 University Of New Mexico Miniature implantable refillable glucose sensor and material therefor
US4986271A (en) 1989-07-19 1991-01-22 The University Of New Mexico Vivo refillable glucose sensor
US5013161A (en) 1989-07-28 1991-05-07 Becton, Dickinson And Company Electronic clinical thermometer
US5320725A (en) 1989-08-02 1994-06-14 E. Heller & Company Electrode and method for the detection of hydrogen peroxide
US5262035A (en) 1989-08-02 1993-11-16 E. Heller And Company Enzyme electrodes
US5264104A (en) 1989-08-02 1993-11-23 Gregg Brian A Enzyme electrodes
US5264105A (en) 1989-08-02 1993-11-23 Gregg Brian A Enzyme electrodes
US4944299A (en) 1989-08-08 1990-07-31 Siemens-Pacesetter, Inc. High speed digital telemetry system for implantable device
US5190041A (en) 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
US5101814A (en) 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US5095904A (en) 1989-09-08 1992-03-17 Cochlear Pty. Ltd. Multi-peak speech procession
US5050612A (en) 1989-09-12 1991-09-24 Matsumura Kenneth N Device for computer-assisted monitoring of the body
FR2652736A1 (fr) 1989-10-06 1991-04-12 Neftel Frederic Dispositif implantable d'evaluation du taux de glucose.
US5036860A (en) 1989-11-24 1991-08-06 Medical Device Technologies, Inc. Disposable soft tissue biopsy apparatus
DE69025134T2 (de) 1989-11-24 1996-08-14 Matsushita Electric Ind Co Ltd Verfahren zur Herstellung eines Biosensors
US5082550A (en) 1989-12-11 1992-01-21 The United States Of America As Represented By The Department Of Energy Enzyme electrochemical sensor electrode and method of making it
US5140985A (en) 1989-12-11 1992-08-25 Schroeder Jon M Noninvasive blood glucose measuring device
US5342789A (en) 1989-12-14 1994-08-30 Sensor Technologies, Inc. Method and device for detecting and quantifying glucose in body fluids
DE69020908T2 (de) 1989-12-15 1996-02-15 Boehringer Mannheim Corp Redox-vermittlungs-reagenz und biosensor.
US5286362A (en) 1990-02-03 1994-02-15 Boehringer Mannheim Gmbh Method and sensor electrode system for the electrochemical determination of an analyte or an oxidoreductase as well as the use of suitable compounds therefor
US5109850A (en) 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus
US5165407A (en) 1990-04-19 1992-11-24 The University Of Kansas Implantable glucose sensor
US5161532A (en) 1990-04-19 1992-11-10 Teknekron Sensor Development Corporation Integral interstitial fluid sensor
US5202261A (en) 1990-07-19 1993-04-13 Miles Inc. Conductive sensors and their use in diagnostic assays
US5250439A (en) 1990-07-19 1993-10-05 Miles Inc. Use of conductive sensors in diagnostic assays
ATE106015T1 (de) 1990-09-28 1994-06-15 Pfizer Wirkstoffabgabevorrichtung die ein hydrophobisches mittel enthält.
US5058592A (en) 1990-11-02 1991-10-22 Whisler G Douglas Adjustable mountable doppler ultrasound transducer device
WO1992010133A1 (en) 1990-12-12 1992-06-25 Intelligent Medical Systems, Inc. Infrared thermometer utilizing calibration mapping
FR2673289B1 (fr) 1991-02-21 1994-06-17 Asulab Sa Capteur de mesure de la quantite d'un composant en solution.
JPH04278450A (ja) 1991-03-04 1992-10-05 Adam Heller バイオセンサー及び分析物を分析する方法
US5593852A (en) 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
US5262305A (en) 1991-03-04 1993-11-16 E. Heller & Company Interferant eliminating biosensors
US5469855A (en) 1991-03-08 1995-11-28 Exergen Corporation Continuous temperature monitor
US5238729A (en) 1991-04-05 1993-08-24 Minnesota Mining And Manufacturing Company Sensors based on nanosstructured composite films
US5208154A (en) 1991-04-08 1993-05-04 The United States Of America As Represented By The Department Of Energy Reversibly immobilized biological materials in monolayer films on electrodes
US5192416A (en) 1991-04-09 1993-03-09 New Mexico State University Technology Transfer Corporation Method and apparatus for batch injection analysis
US5293546A (en) 1991-04-17 1994-03-08 Martin Marietta Corporation Oxide coated metal grid electrode structure in display devices
US5122925A (en) 1991-04-22 1992-06-16 Control Products, Inc. Package for electronic components
JP3118015B2 (ja) 1991-05-17 2000-12-18 アークレイ株式会社 バイオセンサーおよびそれを用いた分離定量方法
US5209229A (en) 1991-05-20 1993-05-11 Telectronics Pacing Systems, Inc. Apparatus and method employing plural electrode configurations for cardioversion of atrial fibrillation in an arrhythmia control system
FI88223C (fi) 1991-05-22 1993-04-13 Polar Electro Oy Telemetrisk saendarenhet
JP2816262B2 (ja) 1991-07-09 1998-10-27 工業技術院長 炭素微小センサー電極およびその製造方法
US5284156A (en) 1991-08-30 1994-02-08 M3 Systems, Inc. Automatic tissue sampling apparatus
GB9120144D0 (en) 1991-09-20 1991-11-06 Imperial College A dialysis electrode device
US5234835A (en) 1991-09-26 1993-08-10 C.R. Bard, Inc. Precalibrated fiber optic sensing method
US5322063A (en) 1991-10-04 1994-06-21 Eli Lilly And Company Hydrophilic polyurethane membranes for electrochemical glucose sensors
US5264103A (en) 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
US5217595A (en) 1991-10-25 1993-06-08 The Yellow Springs Instrument Company, Inc. Electrochemical gas sensor
US5415164A (en) 1991-11-04 1995-05-16 Biofield Corp. Apparatus and method for screening and diagnosing trauma or disease in body tissues
DE4139122C1 (zh) 1991-11-28 1993-04-08 Fenzlein, Paul-Gerhard, 8500 Nuernberg, De
US5372427A (en) 1991-12-19 1994-12-13 Texas Instruments Incorporated Temperature sensor
US5271815A (en) 1991-12-26 1993-12-21 Via Medical Corporation Method for measuring glucose
US5285792A (en) 1992-01-10 1994-02-15 Physio-Control Corporation System for producing prioritized alarm messages in a medical instrument
US5246867A (en) 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
NL9200207A (nl) 1992-02-05 1993-09-01 Nedap Nv Implanteerbare biomedische sensorinrichting, in het bijzonder voor meting van de glucoseconcentratie.
US5328927A (en) 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
US5263244A (en) 1992-04-17 1993-11-23 Gould Inc. Method of making a flexible printed circuit sensor assembly for detecting optical pulses
US5711001A (en) 1992-05-08 1998-01-20 Motorola, Inc. Method and circuit for acquisition by a radio receiver
US6785568B2 (en) 1992-05-18 2004-08-31 Non-Invasive Technology Inc. Transcranial examination of the brain
GB9211402D0 (en) 1992-05-29 1992-07-15 Univ Manchester Sensor devices
US6283761B1 (en) 1992-09-08 2001-09-04 Raymond Anthony Joao Apparatus and method for processing and/or for providing healthcare information and/or healthcare-related information
US5400782A (en) 1992-10-07 1995-03-28 Graphic Controls Corporation Integral medical electrode including a fusible conductive substrate
US5421816A (en) 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
US5387327A (en) 1992-10-19 1995-02-07 Duquesne University Of The Holy Ghost Implantable non-enzymatic electrochemical glucose sensor
US5320098A (en) 1992-10-20 1994-06-14 Sun Microsystems, Inc. Optical transdermal link
WO1994010553A1 (en) 1992-10-23 1994-05-11 Optex Biomedical, Inc. Fibre-optic probe for the measurement of fluid parameters
US5601435A (en) 1994-11-04 1997-02-11 Intercare Method and apparatus for interactively monitoring a physiological condition and for interactively providing health related information
US5918603A (en) 1994-05-23 1999-07-06 Health Hero Network, Inc. Method for treating medical conditions using a microprocessor-based video game
US5956501A (en) 1997-01-10 1999-09-21 Health Hero Network, Inc. Disease simulation system and method
US5899855A (en) 1992-11-17 1999-05-04 Health Hero Network, Inc. Modular microprocessor-based health monitoring system
ZA938555B (en) 1992-11-23 1994-08-02 Lilly Co Eli Technique to improve the performance of electrochemical sensors
DK148592D0 (da) 1992-12-10 1992-12-10 Novo Nordisk As Apparat
US5299571A (en) 1993-01-22 1994-04-05 Eli Lilly And Company Apparatus and method for implantation of sensors
FR2701117B1 (fr) 1993-02-04 1995-03-10 Asulab Sa Système de mesures électrochimiques à capteur multizones, et son application au dosage du glucose.
ES2139684T3 (es) 1993-04-23 2000-02-16 Roche Diagnostics Gmbh Sistema para el almacenamiento de elementos de ensayo.
US5540664A (en) 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
DE4318519C2 (de) 1993-06-03 1996-11-28 Fraunhofer Ges Forschung Elektrochemischer Sensor
US5575563A (en) 1993-07-15 1996-11-19 Chiu; Job Multiusage thermometer
US5582184A (en) 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5791344A (en) 1993-11-19 1998-08-11 Alfred E. Mann Foundation For Scientific Research Patient monitoring system
US5497772A (en) 1993-11-19 1996-03-12 Alfred E. Mann Foundation For Scientific Research Glucose monitoring system
US5724968A (en) 1993-12-29 1998-03-10 First Opinion Corporation Computerized medical diagnostic system including meta function
US5589326A (en) 1993-12-30 1996-12-31 Boehringer Mannheim Corporation Osmium-containing redox mediator
US5320715A (en) 1994-01-14 1994-06-14 Lloyd Berg Separation of 1-pentanol from cyclopentanol by extractive distillation
US5437999A (en) 1994-02-22 1995-08-01 Boehringer Mannheim Corporation Electrochemical sensor
US5543326A (en) 1994-03-04 1996-08-06 Heller; Adam Biosensor including chemically modified enzymes
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
US5390671A (en) 1994-03-15 1995-02-21 Minimed Inc. Transcutaneous sensor insertion set
US5391250A (en) 1994-03-15 1995-02-21 Minimed Inc. Method of fabricating thin film sensors
US5569186A (en) 1994-04-25 1996-10-29 Minimed Inc. Closed loop infusion pump system with removable glucose sensor
JP3061351B2 (ja) 1994-04-25 2000-07-10 松下電器産業株式会社 特定化合物の定量法およびその装置
DE4415896A1 (de) 1994-05-05 1995-11-09 Boehringer Mannheim Gmbh Analysesystem zur Überwachung der Konzentration eines Analyten im Blut eines Patienten
US5545191A (en) 1994-05-06 1996-08-13 Alfred E. Mann Foundation For Scientific Research Method for optimally positioning and securing the external unit of a transcutaneous transducer of the skin of a living body
US5494562A (en) 1994-06-27 1996-02-27 Ciba Corning Diagnostics Corp. Electrochemical sensors
CA2159052C (en) 1994-10-28 2007-03-06 Rainer Alex Injection device
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US5632557A (en) 1994-12-16 1997-05-27 Weed Instrument Company, Inc. Modular temperature sensing apparatus
US5562713A (en) 1995-01-18 1996-10-08 Pacesetter, Inc. Bidirectional telemetry apparatus and method for implantable device
US5551427A (en) 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5568806A (en) 1995-02-16 1996-10-29 Minimed Inc. Transcutaneous sensor insertion set
US5586553A (en) 1995-02-16 1996-12-24 Minimed Inc. Transcutaneous sensor insertion set
US5651869A (en) 1995-02-28 1997-07-29 Matsushita Electric Industrial Co., Ltd. Biosensor
US5596150A (en) 1995-03-08 1997-01-21 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Capacitance probe for fluid flow and volume measurements
JPH08247987A (ja) 1995-03-15 1996-09-27 Omron Corp 携帯型測定器
US5582697A (en) 1995-03-17 1996-12-10 Matsushita Electric Industrial Co., Ltd. Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same
US5788833A (en) 1995-03-27 1998-08-04 California Institute Of Technology Sensors for detecting analytes in fluids
US5628310A (en) 1995-05-19 1997-05-13 Joseph R. Lakowicz Method and apparatus to perform trans-cutaneous analyte monitoring
US5584813A (en) 1995-06-07 1996-12-17 Minimed Inc. Subcutaneous injection set
US5743262A (en) 1995-06-07 1998-04-28 Masimo Corporation Blood glucose monitoring system
US5567302A (en) 1995-06-07 1996-10-22 Molecular Devices Corporation Electrochemical system for rapid detection of biochemical agents that catalyze a redox potential change
US5638832A (en) 1995-06-07 1997-06-17 Interval Research Corporation Programmable subcutaneous visible implant
US5995860A (en) 1995-07-06 1999-11-30 Thomas Jefferson University Implantable sensor and system for measurement and control of blood constituent levels
US6001065A (en) 1995-08-02 1999-12-14 Ibva Technologies, Inc. Method and apparatus for measuring and analyzing physiological signals for active or passive control of physical and virtual spaces and the contents therein
US5766131A (en) 1995-08-04 1998-06-16 Seiko Epson Corporation Pulse-wave measuring apparatus
US5749656A (en) 1995-08-11 1998-05-12 General Motors Corporation Thermal probe assembly with mold-over crimp sensor packaging
DE19530376C2 (de) 1995-08-18 1999-09-02 Fresenius Ag Biosensor
US5682233A (en) 1995-09-08 1997-10-28 Integ, Inc. Interstitial fluid sampler
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
DE19534887B4 (de) 1995-09-20 2004-04-15 Robert Bosch Gmbh Temperaturfühler
US5628890A (en) 1995-09-27 1997-05-13 Medisense, Inc. Electrochemical sensor
US5972199A (en) 1995-10-11 1999-10-26 E. Heller & Company Electrochemical analyte sensors using thermostable peroxidase
US5665222A (en) 1995-10-11 1997-09-09 E. Heller & Company Soybean peroxidase electrochemical sensor
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
US5711861A (en) 1995-11-22 1998-01-27 Ward; W. Kenneth Device for monitoring changes in analyte concentration
ZA9610374B (en) 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
US5827184A (en) 1995-12-29 1998-10-27 Minnesota Mining And Manufacturing Company Self-packaging bioelectrodes
JPH09201338A (ja) * 1996-01-26 1997-08-05 Hiromichi Omura 可撓性生体情報発信装置
US5746697A (en) 1996-02-09 1998-05-05 Nellcor Puritan Bennett Incorporated Medical diagnostic apparatus with sleep mode
FI118509B (fi) 1996-02-12 2007-12-14 Nokia Oyj Menetelmä ja laitteisto potilaan veren glukoosipitoisuuden ennustamiseksi
FI960636A (fi) 1996-02-12 1997-08-13 Nokia Mobile Phones Ltd Menetelmä potilaan terveydentilan valvomiseksi
US5708247A (en) 1996-02-14 1998-01-13 Selfcare, Inc. Disposable glucose test strips, and methods and compositions for making same
CA2248643A1 (en) 1996-04-08 1997-10-16 Medtronic, Inc. Method of fixing a physiologic mitral valve bioprosthesis
DE19618597B4 (de) 1996-05-09 2005-07-21 Institut für Diabetestechnologie Gemeinnützige Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm Verfahren zur Bestimmung der Konzentration von Gewebeglucose
US5954685A (en) 1996-05-24 1999-09-21 Cygnus, Inc. Electrochemical sensor with dual purpose electrode
US5613978A (en) 1996-06-04 1997-03-25 Palco Laboratories Adjustable tip for lancet device
US5735285A (en) 1996-06-04 1998-04-07 Data Critical Corp. Method and hand-held apparatus for demodulating and viewing frequency modulated biomedical signals
DE69719761T2 (de) 1996-06-18 2003-12-18 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
JP2000515778A (ja) 1996-07-08 2000-11-28 アニマス コーポレーシヨン 体液成分レベルの生体内測定および制御のための埋込可能センサーおよびシステム
US5693024A (en) * 1996-09-27 1997-12-02 Becton Dickinson And Company Iontophoretic drug delivery system, including method for determining hydration of patch
US5771001A (en) 1996-11-18 1998-06-23 Cobb; Marlon J. Personal alarm system
US6004278A (en) 1996-12-05 1999-12-21 Mdc Investment Holdings, Inc. Fluid collection device with retractable needle
US6071251A (en) 1996-12-06 2000-06-06 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
US5964993A (en) 1996-12-19 1999-10-12 Implanted Biosystems Inc. Glucose sensor
US6122351A (en) 1997-01-21 2000-09-19 Med Graph, Inc. Method and system aiding medical diagnosis and treatment
US6093172A (en) 1997-02-05 2000-07-25 Minimed Inc. Injector for a subcutaneous insertion set
US20070142776A9 (en) 1997-02-05 2007-06-21 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
US6607509B2 (en) 1997-12-31 2003-08-19 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
US7329239B2 (en) 1997-02-05 2008-02-12 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
US5851197A (en) 1997-02-05 1998-12-22 Minimed Inc. Injector for a subcutaneous infusion set
JP3394262B2 (ja) 1997-02-06 2003-04-07 セラセンス、インク． 小体積インビトロ被検体センサー
US6309884B1 (en) 1997-02-26 2001-10-30 Diasense, Inc. Individual calibration of blood glucose for supporting noninvasive self-monitoring blood glucose
US6159147A (en) 1997-02-28 2000-12-12 Qrs Diagnostics, Llc Personal computer card for collection of real-time biological data
US7657297B2 (en) 2004-05-03 2010-02-02 Dexcom, Inc. Implantable analyte sensor
US6558321B1 (en) 1997-03-04 2003-05-06 Dexcom, Inc. Systems and methods for remote monitoring and modulation of medical devices
US6741877B1 (en) 1997-03-04 2004-05-25 Dexcom, Inc. Device and method for determining analyte levels
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US7192450B2 (en) 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US20050033132A1 (en) 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
US6554795B2 (en) 1997-03-06 2003-04-29 Medtronic Ave, Inc. Balloon catheter and method of manufacture
US6270455B1 (en) 1997-03-28 2001-08-07 Health Hero Network, Inc. Networked system for interactive communications and remote monitoring of drug delivery
US6026321A (en) 1997-04-02 2000-02-15 Suzuki Motor Corporation Apparatus and system for measuring electrical potential variations in human body
US5961451A (en) 1997-04-07 1999-10-05 Motorola, Inc. Noninvasive apparatus having a retaining member to retain a removable biosensor
US5942979A (en) 1997-04-07 1999-08-24 Luppino; Richard On guard vehicle safety warning system
US5987353A (en) 1997-04-10 1999-11-16 Khatchatrian; Robert G. Diagnostic complex for measurement of the condition of biological tissues and liquids
US6059946A (en) 1997-04-14 2000-05-09 Matsushita Electric Industrial Co., Ltd. Biosensor
US6186982B1 (en) 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
US5779665A (en) 1997-05-08 1998-07-14 Minimed Inc. Transdermal introducer assembly
US7267665B2 (en) 1999-06-03 2007-09-11 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US5954643A (en) 1997-06-09 1999-09-21 Minimid Inc. Insertion set for a transcutaneous sensor
AU8031898A (en) 1997-06-16 1999-01-04 Elan Medical Technologies Limited Methods of calibrating and testing a sensor for (in vivo) measurement of an analyte and devices for use in such methods
US6232950B1 (en) 1997-08-28 2001-05-15 E Ink Corporation Rear electrode structures for displays
US6764581B1 (en) 1997-09-05 2004-07-20 Abbott Laboratories Electrode with thin working layer
US6071391A (en) 1997-09-12 2000-06-06 Nok Corporation Enzyme electrode structure
US6117290A (en) 1997-09-26 2000-09-12 Pepex Biomedical, Llc System and method for measuring a bioanalyte such as lactate
US20020013538A1 (en) 1997-09-30 2002-01-31 David Teller Method and apparatus for health signs monitoring
US5904671A (en) 1997-10-03 1999-05-18 Navot; Nir Tampon wetness detection system
US5938679A (en) 1997-10-14 1999-08-17 Hewlett-Packard Company Apparatus and method for minimally invasive blood sampling
US6736957B1 (en) 1997-10-16 2004-05-18 Abbott Laboratories Biosensor electrode mediators for regeneration of cofactors and process for using
US6119028A (en) 1997-10-20 2000-09-12 Alfred E. Mann Foundation Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces
US6088608A (en) 1997-10-20 2000-07-11 Alfred E. Mann Foundation Electrochemical sensor and integrity tests therefor
FI107080B (fi) 1997-10-27 2001-05-31 Nokia Mobile Phones Ltd Mittauslaite
US6068399A (en) 1997-11-12 2000-05-30 K-Jump Health Co., Ltd. Cost-effective electronic thermometer
DE69836979T2 (de) 1997-11-12 2007-11-08 Lightouch Medical, Inc. Verfahren zur nicht invasiven analytenmessung
US6482176B1 (en) 1997-11-27 2002-11-19 Disetronic Licensing Ag Method and device for controlling the introduction depth of an injection needle
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6579690B1 (en) 1997-12-05 2003-06-17 Therasense, Inc. Blood analyte monitoring through subcutaneous measurement
JP4647098B2 (ja) 1997-12-31 2011-03-09 メドトロニック ミニメド インコーポレイテッド 挿入セットのための挿入装置
EP1743667B1 (en) 1997-12-31 2012-02-22 Medtronic MiniMed, Inc. Insertion device for an insertion set
US6804543B2 (en) 1998-02-05 2004-10-12 Hema Metrics, Inc. Sensor for transcutaneous measurement of vascular access blood flow
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6056718A (en) 1998-03-04 2000-05-02 Minimed Inc. Medication infusion set
US6103033A (en) 1998-03-04 2000-08-15 Therasense, Inc. Process for producing an electrochemical biosensor
US6024699A (en) 1998-03-13 2000-02-15 Healthware Corporation Systems, methods and computer program products for monitoring, diagnosing and treating medical conditions of remotely located patients
US6197181B1 (en) 1998-03-20 2001-03-06 Semitool, Inc. Apparatus and method for electrolytically depositing a metal on a microelectronic workpiece
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6728560B2 (en) 1998-04-06 2004-04-27 The General Hospital Corporation Non-invasive tissue glucose level monitoring
JPH11296598A (ja) 1998-04-07 1999-10-29 Seizaburo Arita 血糖値の予測システム及び予測方法並びにこの方法を記録した記録媒体
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
GB2337122B (en) 1998-05-08 2002-11-13 Medisense Inc Test strip
DK1077636T3 (da) 1998-05-13 2004-05-24 Cygnus Therapeutic Systems Signalbehandling til måling af fysiologiske analytter
DE19821723C2 (de) 1998-05-14 2000-07-06 Disetronic Licensing Ag Katheterkopf für subkutane Verabreichung eines Wirkstoffs
US6121611A (en) 1998-05-20 2000-09-19 Molecular Imaging Corporation Force sensing probe for scanning probe microscopy
US6302855B1 (en) * 1998-05-20 2001-10-16 Novo Nordisk A/S Medical apparatus for use by a patient for medical self treatment of diabetes
US5951582A (en) 1998-05-22 1999-09-14 Specialized Health Products, Inc. Lancet apparatus and methods
US6837885B2 (en) 1998-05-22 2005-01-04 Scimed Life Systems, Inc. Surgical probe for supporting inflatable therapeutic devices in contact with tissue in or around body orifices and within tumors
GB9812472D0 (en) 1998-06-11 1998-08-05 Owen Mumford Ltd A dose setting device for medical injectors
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US6248067B1 (en) 1999-02-05 2001-06-19 Minimed Inc. Analyte sensor and holter-type monitor system and method of using the same
US5993423A (en) 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6096066A (en) * 1998-09-11 2000-08-01 Light Sciences Limited Partnership Conformal patch for administering light therapy to subcutaneous tumors
US5951521A (en) 1998-09-25 1999-09-14 Minimed Inc. Subcutaneous implantable sensor set having the capability to remove deliver fluids to an insertion site
US6254586B1 (en) 1998-09-25 2001-07-03 Minimed Inc. Method and kit for supplying a fluid to a subcutaneous placement site
WO2000018289A1 (en) 1998-09-30 2000-04-06 Cygnus, Inc. Method and device for predicting physiological values
US6591125B1 (en) 2000-06-27 2003-07-08 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
CA2666434A1 (en) 1998-10-08 2000-04-13 Medtronic Minimed, Inc. Telemetered characteristic monitor system
WO2000030532A1 (en) 1998-11-20 2000-06-02 University Of Connecticut Generic integrated implantable potentiostat telemetry unit for electrochemical sensors
US6773671B1 (en) 1998-11-30 2004-08-10 Abbott Laboratories Multichemistry measuring device and test strips
US6377894B1 (en) 1998-11-30 2002-04-23 Abbott Laboratories Analyte test instrument having improved calibration and communication processes
US6022368A (en) 1998-11-30 2000-02-08 Gavronsky; Stas Acupuncture method and device
US6161095A (en) 1998-12-16 2000-12-12 Health Hero Network, Inc. Treatment regimen compliance and efficacy with feedback
US6433728B1 (en) 1999-01-22 2002-08-13 Lear Automotive Dearborn, Inc. Integrally molded remote entry transmitter
EP1135052A1 (en) 1999-02-12 2001-09-26 Cygnus, Inc. Devices and methods for frequent measurement of an analyte present in a biological system
US6424847B1 (en) 1999-02-25 2002-07-23 Medtronic Minimed, Inc. Glucose monitor calibration methods
US6360888B1 (en) 1999-02-25 2002-03-26 Minimed Inc. Glucose sensor package system
DK1154719T3 (da) 1999-02-25 2012-07-23 Medtronic Minimed Inc Prøvestik og kabel til en glucosemonitor
US6285897B1 (en) 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
US6200265B1 (en) 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
FR2793021B1 (fr) 1999-04-30 2001-08-03 Siemens Automotive Sa Capteur de temperature et procede de fabrication d'un tel capteur
US6359444B1 (en) 1999-05-28 2002-03-19 University Of Kentucky Research Foundation Remote resonant-circuit analyte sensing apparatus with sensing structure and associated method of sensing
US6546268B1 (en) 1999-06-02 2003-04-08 Ball Semiconductor, Inc. Glucose sensor
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
GB2351153B (en) 1999-06-18 2003-03-26 Abbott Lab Electrochemical sensor for analysis of liquid samples
US6423035B1 (en) 1999-06-18 2002-07-23 Animas Corporation Infusion pump with a sealed drive mechanism and improved method of occlusion detection
WO2000078992A2 (en) 1999-06-18 2000-12-28 Therasense, Inc. Mass transport limited in vivo analyte sensor
US6368274B1 (en) 1999-07-01 2002-04-09 Medtronic Minimed, Inc. Reusable analyte sensor site and method of using the same
US6413393B1 (en) 1999-07-07 2002-07-02 Minimed, Inc. Sensor including UV-absorbing polymer and method of manufacture
US6514460B1 (en) 1999-07-28 2003-02-04 Abbott Laboratories Luminous glucose monitoring device
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
AT408182B (de) 1999-09-17 2001-09-25 Schaupp Lukas Dipl Ing Dr Tech Einrichtung zur in vivo-messung von grössen in lebenden organismen
WO2001028416A1 (en) 1999-09-24 2001-04-26 Healthetech, Inc. Physiological monitor and associated computation, display and communication unit
CA2387124A1 (en) 1999-10-08 2001-04-26 Healthetech, Inc. Integrated calorie management system
DE19948759A1 (de) 1999-10-09 2001-04-12 Roche Diagnostics Gmbh Blutlanzettenvorrichtung zur Entnahme von Blut für Diagnosezwecke
US6283982B1 (en) 1999-10-19 2001-09-04 Facet Technologies, Inc. Lancing device and method of sample collection
US20060091006A1 (en) 1999-11-04 2006-05-04 Yi Wang Analyte sensor with insertion monitor, and methods
US6616819B1 (en) 1999-11-04 2003-09-09 Therasense, Inc. Small volume in vitro analyte sensor and methods
JP3985022B2 (ja) 1999-11-08 2007-10-03 アークレイ株式会社 体液測定装置、およびこの体液測定装置に挿着して使用する挿着体
AU1607801A (en) 1999-11-15 2001-05-30 Therasense, Inc. Transition metal complexes with bidentate ligand having an imidazole ring
GB9927842D0 (en) 1999-11-26 2000-01-26 Koninkl Philips Electronics Nv Improved fabric antenna
AU1889001A (en) 1999-12-13 2001-06-18 Arkray, Inc. Body fluid measuring apparatus with lancet and lancet holder used for the measuring apparatus
US7369635B2 (en) 2000-01-21 2008-05-06 Medtronic Minimed, Inc. Rapid discrimination preambles and methods for using the same
US6564105B2 (en) 2000-01-21 2003-05-13 Medtronic Minimed, Inc. Method and apparatus for communicating between an ambulatory medical device and a control device via telemetry using randomized data
US6484045B1 (en) 2000-02-10 2002-11-19 Medtronic Minimed, Inc. Analyte sensor and method of making the same
US7003336B2 (en) 2000-02-10 2006-02-21 Medtronic Minimed, Inc. Analyte sensor method of making the same
US6895263B2 (en) 2000-02-23 2005-05-17 Medtronic Minimed, Inc. Real time self-adjusting calibration algorithm
US6706159B2 (en) 2000-03-02 2004-03-16 Diabetes Diagnostics Combined lancet and electrochemical analyte-testing apparatus
DE10010587A1 (de) 2000-03-03 2001-09-06 Roche Diagnostics Gmbh System zur Bestimmung von Analytkonzentrationen in Körperflüssigkeiten
US6551496B1 (en) 2000-03-03 2003-04-22 Ysi Incorporated Microstructured bilateral sensor
US6435017B1 (en) 2000-03-16 2002-08-20 Motorola, Inc. Snap-fit sensing apparatus
US6610012B2 (en) 2000-04-10 2003-08-26 Healthetech, Inc. System and method for remote pregnancy monitoring
US6440068B1 (en) 2000-04-28 2002-08-27 International Business Machines Corporation Measuring user health as measured by multiple diverse health measurement devices utilizing a personal storage device
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
WO2001088524A1 (en) 2000-05-12 2001-11-22 Therasense, Inc. Electrodes with multilayer membranes and methods of using and making the electrodes
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
US6442413B1 (en) 2000-05-15 2002-08-27 James H. Silver Implantable sensor
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US7530964B2 (en) 2000-06-30 2009-05-12 Elan Pharma International Limited Needle device and method thereof
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
WO2002015777A1 (en) 2000-08-18 2002-02-28 Cygnus, Inc. Methods and devices for prediction of hypoglycemic events
US6633772B2 (en) 2000-08-18 2003-10-14 Cygnus, Inc. Formulation and manipulation of databases of analyte and associated values
US6827899B2 (en) 2000-08-30 2004-12-07 Hypoguard Limited Test device
ES2287156T3 (es) 2000-09-08 2007-12-16 Insulet Corporation Dispositivos y sistemas para la infusion de un paciente.
ATE553440T1 (de) * 2000-10-04 2012-04-15 Insulet Corp Anordnung zum erfassen von daten für ein infusionssystem
US6712025B2 (en) 2000-10-13 2004-03-30 Dogwatch, Inc. Receiver/stimulus unit for an animal control system
CA2426330A1 (en) 2000-11-01 2002-05-10 3M Innovative Properties Company Electrical sensing and/or signal application device
ES2300082T3 (es) * 2000-11-09 2008-06-01 Insulet Corporation Medio de suministro transcutaneo.
US6695860B1 (en) 2000-11-13 2004-02-24 Isense Corp. Transcutaneous sensor insertion device
ES2717656T3 (es) 2000-11-30 2019-06-24 Valeritas Inc Dispositivo con microsonda amovible sustancialmente libre sobre el alojamiento
US6439446B1 (en) 2000-12-01 2002-08-27 Stephen J. Perry Safety lockout for actuator shaft
US7052483B2 (en) 2000-12-19 2006-05-30 Animas Corporation Transcutaneous inserter for low-profile infusion sets
US6416332B1 (en) 2000-12-20 2002-07-09 Nortel Networks Limited Direct BGA socket for high speed use
US6811538B2 (en) 2000-12-29 2004-11-02 Ares Medical, Inc. Sleep apnea risk evaluation
EP1285629B1 (en) 2001-01-19 2013-05-22 Panasonic Corporation Lancet-integrated sensor and measurer for lancet-integrated sensor
WO2002056751A2 (en) 2001-01-22 2002-07-25 Roche Diagnostics Gmbh Lancet device having capillary action
US20030023461A1 (en) 2001-03-14 2003-01-30 Dan Quintanilla Internet based therapy management system
US6968294B2 (en) 2001-03-15 2005-11-22 Koninklijke Philips Electronics N.V. Automatic system for monitoring person requiring care and his/her caretaker
US7041468B2 (en) 2001-04-02 2006-05-09 Therasense, Inc. Blood glucose tracking apparatus and methods
EP1383560B2 (de) 2001-04-06 2023-04-26 F. Hoffmann-La Roche AG Infusionsset
US6535764B2 (en) 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
JP2004532526A (ja) 2001-05-03 2004-10-21 マシモ・コーポレイション フレックス回路シールド光学センサ及び該フレックス回路シールド光学センサを製造する方法
US6613379B2 (en) 2001-05-08 2003-09-02 Isense Corp. Implantable analyte sensor
US6932894B2 (en) 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US6837988B2 (en) 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
US7179226B2 (en) 2001-06-21 2007-02-20 Animas Corporation System and method for managing diabetes
US20030002682A1 (en) 2001-07-02 2003-01-02 Phonex Broadband Corporation Wireless audio/mechanical vibration transducer and audio/visual transducer
EP1405596B1 (en) 2001-07-11 2010-10-06 ARKRAY, Inc. Lancet
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US6544212B2 (en) 2001-07-31 2003-04-08 Roche Diagnostics Corporation Diabetes management system
US6827718B2 (en) 2001-08-14 2004-12-07 Scimed Life Systems, Inc. Method of and apparatus for positioning and maintaining the position of endoscopic instruments
JP2004538078A (ja) 2001-08-20 2004-12-24 インバネス・メディカル・リミテッド 無線糖尿病管理装置および無線糖尿病管理装置の使用方法
US6740072B2 (en) 2001-09-07 2004-05-25 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US7025760B2 (en) 2001-09-07 2006-04-11 Medtronic Minimed, Inc. Method and system for non-vascular sensor implantation
JP2003084101A (ja) 2001-09-17 2003-03-19 Dainippon Printing Co Ltd 光学素子用樹脂組成物、光学素子、およびプロジェクションスクリーン
US7052591B2 (en) 2001-09-21 2006-05-30 Therasense, Inc. Electrodeposition of redox polymers and co-electrodeposition of enzymes by coordinative crosslinking
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US20030069510A1 (en) 2001-10-04 2003-04-10 Semler Herbert J. Disposable vital signs monitor
US6613015B2 (en) 2001-10-04 2003-09-02 Deltec, Inc. Right angle safety needle
US6748254B2 (en) 2001-10-12 2004-06-08 Nellcor Puritan Bennett Incorporated Stacked adhesive optical sensor
US6971999B2 (en) 2001-11-14 2005-12-06 Medical Instill Technologies, Inc. Intradermal delivery device and method
US20030145062A1 (en) 2002-01-14 2003-07-31 Dipanshu Sharma Data conversion server for voice browsing system
US20030155656A1 (en) 2002-01-18 2003-08-21 Chiu Cindy Chia-Wen Anisotropically conductive film
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US7379765B2 (en) 2003-07-25 2008-05-27 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US8858434B2 (en) 2004-07-13 2014-10-14 Dexcom, Inc. Transcutaneous analyte sensor
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
DE10208575C1 (de) 2002-02-21 2003-08-14 Hartmann Paul Ag Blutanalysegerät zur Bestimmung eines Analyten
US20030212379A1 (en) 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
AU2003213638A1 (en) 2002-02-26 2003-09-09 Sterling Medivations, Inc. Insertion device for an insertion set and method of using the same
WO2003073936A2 (en) 2002-03-06 2003-09-12 'htl Strefa' Sp. Z O.O. A device for puncturing patient's skin
US6998247B2 (en) 2002-03-08 2006-02-14 Sensys Medical, Inc. Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
US6936006B2 (en) 2002-03-22 2005-08-30 Novo Nordisk, A/S Atraumatic insertion of a subcutaneous device
GB2388898B (en) 2002-04-02 2005-10-05 Inverness Medical Ltd Integrated sample testing meter
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7485128B2 (en) 2002-04-19 2009-02-03 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US6960192B1 (en) * 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US8641715B2 (en) 2002-05-31 2014-02-04 Vidacare Corporation Manual intraosseous device
US7470238B2 (en) 2002-07-02 2008-12-30 Arkray, Inc. Unit for piercing, and piercing device
US20040010207A1 (en) 2002-07-15 2004-01-15 Flaherty J. Christopher Self-contained, automatic transcutaneous physiologic sensing system
US7034677B2 (en) 2002-07-19 2006-04-25 Smiths Detection Inc. Non-specific sensor array detectors
US7278983B2 (en) 2002-07-24 2007-10-09 Medtronic Minimed, Inc. Physiological monitoring device for controlling a medication infusion device
US7637891B2 (en) 2002-09-12 2009-12-29 Children's Hospital Medical Center Method and device for painless injection of medication
US7736309B2 (en) 2002-09-27 2010-06-15 Medtronic Minimed, Inc. Implantable sensor method and system
US7192405B2 (en) 2002-09-30 2007-03-20 Becton, Dickinson And Company Integrated lancet and bodily fluid sensor
US7014625B2 (en) 2002-10-07 2006-03-21 Novo Nordick A/S Needle insertion device
TW557352B (en) 2002-10-07 2003-10-11 Actherm Inc Electronic clinical thermometer with rapid response
US20040138688A1 (en) 2002-10-09 2004-07-15 Jean Pierre Giraud Lancet system including test strips and cassettes for drawing and sampling bodily material
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US7572237B2 (en) 2002-11-06 2009-08-11 Abbott Diabetes Care Inc. Automatic biological analyte testing meter with integrated lancing device and methods of use
US6676290B1 (en) 2002-11-15 2004-01-13 Hsueh-Yu Lu Electronic clinical thermometer
JP4359675B2 (ja) 2002-12-13 2009-11-04 アークレイ株式会社 穿刺装置
AU2003293559A1 (en) 2002-12-16 2004-07-22 Meagan Medical, Inc. Controlling the depth of percutaneous applications
US20040116866A1 (en) 2002-12-17 2004-06-17 William Gorman Skin attachment apparatus and method for patient infusion device
US20040122353A1 (en) 2002-12-19 2004-06-24 Medtronic Minimed, Inc. Relay device for transferring information between a sensor system and a fluid delivery system
US7395117B2 (en) 2002-12-23 2008-07-01 Cardiac Pacemakers, Inc. Implantable medical device having long-term wireless capabilities
US20040127818A1 (en) 2002-12-27 2004-07-01 Roe Steven N. Precision depth control lancing tip
US7811231B2 (en) 2002-12-31 2010-10-12 Abbott Diabetes Care Inc. Continuous glucose monitoring system and methods of use
US20040138544A1 (en) 2003-01-13 2004-07-15 Ward W. Kenneth Body fluid trap anlyte sensor
US20040140211A1 (en) 2003-01-21 2004-07-22 Broy Stephen H. Modular interface and coupling system and method
US20040171910A1 (en) 2003-02-27 2004-09-02 Moore-Steele Robin B. Sexually stimulating panty insert
US20040186373A1 (en) 2003-03-21 2004-09-23 Dunfield John Stephen Method and device for targeted epithelial delivery of medicinal and related agents
US20050070819A1 (en) 2003-03-31 2005-03-31 Rosedale Medical, Inc. Body fluid sampling constructions and techniques
US7134999B2 (en) 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
WO2004091401A1 (ja) 2003-04-11 2004-10-28 Arkray Inc. 穿刺装置
US6797877B1 (en) 2003-04-28 2004-09-28 Jonn Maneely Company Electrical metallic tube, coupling, and connector apparatus and method
DE602004028231D1 (de) 2003-05-08 2010-09-02 Novo Nordisk As Eine auf die haut aufbringbare injektionsvorrichtung mit abtrennbarem betätigungsteil zum einführen der nadel
US7875293B2 (en) 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US8460243B2 (en) 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
US20040254433A1 (en) 2003-06-12 2004-12-16 Bandis Steven D. Sensor introducer system, apparatus and method
WO2004112602A1 (en) 2003-06-13 2004-12-29 Pelikan Technologies, Inc. Method and apparatus for a point of care device
JP4041018B2 (ja) 2003-06-25 2008-01-30 Ｔｄｋ株式会社 温度センサ
US7510564B2 (en) 2003-06-27 2009-03-31 Abbott Diabetes Care Inc. Lancing device
WO2005019795A2 (en) 2003-07-25 2005-03-03 Dexcom, Inc. Electrochemical sensors including electrode systems with increased oxygen generation
US7424318B2 (en) 2003-12-05 2008-09-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20050176136A1 (en) 2003-11-19 2005-08-11 Dexcom, Inc. Afinity domain for analyte sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US7467003B2 (en) 2003-12-05 2008-12-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7460898B2 (en) 2003-12-05 2008-12-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7366556B2 (en) 2003-12-05 2008-04-29 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
JP2007500336A (ja) 2003-07-25 2007-01-11 デックスコム・インコーポレーテッド 電気化学センサーに用いる電極システム
WO2007120442A2 (en) 2003-07-25 2007-10-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US8626257B2 (en) 2003-08-01 2014-01-07 Dexcom, Inc. Analyte sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
EP1502613A1 (en) * 2003-08-01 2005-02-02 Novo Nordisk A/S Needle device with retraction means
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US7959569B2 (en) 2003-08-01 2011-06-14 Dexcom, Inc. System and methods for processing analyte sensor data
US20100168657A1 (en) 2003-08-01 2010-07-01 Dexcom, Inc. System and methods for processing analyte sensor data
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US6931327B2 (en) 2003-08-01 2005-08-16 Dexcom, Inc. System and methods for processing analyte sensor data
DE10336933B4 (de) 2003-08-07 2007-04-26 Roche Diagnostics Gmbh Blutentnahmesystem
US20050038331A1 (en) * 2003-08-14 2005-02-17 Grayson Silaski Insertable sensor assembly having a coupled inductor communicative system
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
WO2005084534A1 (en) 2003-09-03 2005-09-15 Life Patch International, Inc. Personal diagnostic devices and related methods
JP4356088B2 (ja) 2003-09-26 2009-11-04 日本光電工業株式会社 多チャネル生体信号用テレメータシステム
KR20060099520A (ko) * 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 의료용 피부 장착 장치
US20050090607A1 (en) 2003-10-28 2005-04-28 Dexcom, Inc. Silicone composition for biocompatible membrane
US6928380B2 (en) 2003-10-30 2005-08-09 International Business Machines Corporation Thermal measurements of electronic devices during operation
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
JP2005137416A (ja) 2003-11-04 2005-06-02 Sysmex Corp 経皮的分析物抽出システム及び経皮的分析物分析システム
US20050154410A1 (en) 2003-11-12 2005-07-14 Conway William E. Lancing device and multi-lancet cartridge
EP1691679B1 (en) 2003-11-13 2010-08-11 Medtronic MiniMed, Inc. Long term analyte sensor array
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
US8425416B2 (en) 2006-10-04 2013-04-23 Dexcom, Inc. Analyte sensor
US8364230B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
EP1711790B1 (en) 2003-12-05 2010-09-08 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US8425417B2 (en) 2003-12-05 2013-04-23 Dexcom, Inc. Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device
US20100185071A1 (en) 2003-12-05 2010-07-22 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20080197024A1 (en) 2003-12-05 2008-08-21 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US20080200788A1 (en) 2006-10-04 2008-08-21 Dexcorn, Inc. Analyte sensor
US8532730B2 (en) 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
WO2005057173A2 (en) 2003-12-08 2005-06-23 Dexcom, Inc. Systems and methods for improving electrochemical analyte sensors
EP1711791B1 (en) 2003-12-09 2014-10-15 DexCom, Inc. Signal processing for continuous analyte sensor
US7763042B2 (en) 2003-12-16 2010-07-27 Panasonic Corporation Lancet for blood collection and puncture needle unit
US7637868B2 (en) 2004-01-12 2009-12-29 Dexcom, Inc. Composite material for implantable device
US8465696B2 (en) 2004-02-03 2013-06-18 Polymer Technology Systems, Inc. Dry test strip with controlled flow and method of manufacturing same
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
WO2005079257A2 (en) 2004-02-12 2005-09-01 Dexcom, Inc. Biointerface with macro- and micro- architecture
WO2005089103A2 (en) 2004-02-17 2005-09-29 Therasense, Inc. Method and system for providing data communication in continuous glucose monitoring and management system
CN1921803B (zh) 2004-02-23 2011-01-26 伊西康公司 诊断拭子和活组织检查穿刺器,以及用在这些系统中的诊断帽
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
WO2005084257A2 (en) 2004-02-26 2005-09-15 Vpn Solutions, Llc Composite thin-film glucose sensor
JP4593129B2 (ja) 2004-02-26 2010-12-08 オリンパス株式会社 内視鏡
US7481819B2 (en) 2004-03-02 2009-01-27 Facet Technologies, Llc Compact multi-use lancing device
US6971274B2 (en) 2004-04-02 2005-12-06 Sierra Instruments, Inc. Immersible thermal mass flow meter
US20050222518A1 (en) 2004-04-06 2005-10-06 Genocell, Llc Biopsy and injection catheters
US20060009727A1 (en) 2004-04-08 2006-01-12 Chf Solutions Inc. Method and apparatus for an extracorporeal control of blood glucose
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US9101302B2 (en) 2004-05-03 2015-08-11 Abbott Diabetes Care Inc. Analyte test device
US20050245799A1 (en) 2004-05-03 2005-11-03 Dexcom, Inc. Implantable analyte sensor
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US9380975B2 (en) 2004-05-07 2016-07-05 Becton, Dickinson And Company Contact activated lancet device
WO2005119524A2 (en) 2004-06-04 2005-12-15 Therasense, Inc. Diabetes care host-client architecture and data management system
US7289855B2 (en) 2004-06-09 2007-10-30 Medtronic, Inc. Implantable medical device package antenna
US7299081B2 (en) 2004-06-15 2007-11-20 Abbott Laboratories Analyte test device
US7585287B2 (en) 2004-06-16 2009-09-08 Smiths Medical Md, Inc. Device and method for insertion of a cannula of an infusion device
NZ552047A (en) 2004-06-18 2009-11-27 Nektar Therapeutics Method of treatment of endobronchial infections
US20060001538A1 (en) 2004-06-30 2006-01-05 Ulrich Kraft Methods of monitoring the concentration of an analyte
US8343074B2 (en) 2004-06-30 2013-01-01 Lifescan Scotland Limited Fluid handling devices
US20060015020A1 (en) 2004-07-06 2006-01-19 Dexcom, Inc. Systems and methods for manufacture of an analyte-measuring device including a membrane system
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US20080242961A1 (en) 2004-07-13 2008-10-02 Dexcom, Inc. Transcutaneous analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
EP2335581A1 (en) 2004-07-13 2011-06-22 DexCom, Inc. Transcutaneous analyte sensor
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
US7905833B2 (en) 2004-07-13 2011-03-15 Dexcom, Inc. Transcutaneous analyte sensor
US7857760B2 (en) 2004-07-13 2010-12-28 Dexcom, Inc. Analyte sensor
EP1630898A1 (en) 2004-08-31 2006-03-01 Eidgenössische Technische Hochschule (ETH) Textile antenna
JP2008516714A (ja) 2004-10-18 2008-05-22 ノボ・ノルデイスク・エー／エス 皮下埋込みセンサフィルム、及びセンサフィルムを作成する方法
GB2453069B (en) 2004-11-22 2009-12-09 Intelliject Llc Devices,systems and methods for medicament delivery
DE102004059491B4 (de) 2004-12-10 2008-11-06 Roche Diagnostics Gmbh Lanzettenvorrichtung zum Erzeugen einer Einstichwunde und Lanzettenantriebs-Baugruppe
US20090082693A1 (en) 2004-12-29 2009-03-26 Therasense, Inc. Method and apparatus for providing temperature sensor module in a data communication system
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US20070027381A1 (en) 2005-07-29 2007-02-01 Therasense, Inc. Inserter and methods of use
US9259175B2 (en) * 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US9636450B2 (en) 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US7470237B2 (en) 2005-01-10 2008-12-30 Ethicon Endo-Surgery, Inc. Biopsy instrument with improved needle penetration
US20060166629A1 (en) 2005-01-24 2006-07-27 Therasense, Inc. Method and apparatus for providing EMC Class-B compliant RF transmitter for data monitoring an detection systems
WO2006077262A1 (en) 2005-01-24 2006-07-27 Novo Nordisk A/S Medical device with protected transcutaneous device
US7545272B2 (en) 2005-02-08 2009-06-09 Therasense, Inc. RF tag on test strips, test strip vials and boxes
US7499002B2 (en) 2005-02-08 2009-03-03 International Business Machines Corporation Retractable string interface for stationary and portable devices
US20080147041A1 (en) * 2005-02-28 2008-06-19 Novo Nordisk A/S Device for Providing a Change in a Drug Delivery Rate
KR100638727B1 (ko) 2005-02-28 2006-10-30 삼성전기주식회사 Ｚｉｇｂｅｅ 및 불루투스 겸용 송수신기
US20090076360A1 (en) 2007-09-13 2009-03-19 Dexcom, Inc. Transcutaneous analyte sensor
ES2382049T3 (es) 2005-04-07 2012-06-04 Becton, Dickinson & Company Dispositivo de lanceta
WO2006110193A2 (en) 2005-04-08 2006-10-19 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
US8298172B2 (en) 2005-04-13 2012-10-30 Novo Nordisk A/S Medical skin mountable device and system
US8060174B2 (en) 2005-04-15 2011-11-15 Dexcom, Inc. Analyte sensing biointerface
DE102005019306B4 (de) * 2005-04-26 2011-09-01 Disetronic Licensing Ag Energieoptimierte Datenübertragung eines medizinischen Geräts
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7641649B2 (en) 2005-05-06 2010-01-05 Medtronic Minimed, Inc. Reservoir support and method for infusion device
WO2006133305A2 (en) 2005-06-08 2006-12-14 Sensors For Medicine And Science, Inc. Insertion device and method
EP2260759B1 (de) 2005-06-17 2015-05-06 F. Hoffmann-La Roche AG Sensorsystem sowie Anordnung und Verfahren zur Überwachung eines Inhaltsstoffs, insbesondere Glucose in Körpergewebe
CA2613106A1 (en) 2005-06-30 2007-01-11 Mc3, Inc. Analyte sensors and compositions for use therein
US8298389B2 (en) 2005-09-12 2012-10-30 Abbott Diabetes Care Inc. In vitro analyte sensor, and methods
DE502005009907D1 (de) 2005-09-15 2010-08-26 Roche Diagnostics Gmbh Insertionskopf mit Griff
US9072476B2 (en) 2005-09-23 2015-07-07 Medtronic Minimed, Inc. Flexible sensor apparatus
US7846311B2 (en) 2005-09-27 2010-12-07 Abbott Diabetes Care Inc. In vitro analyte sensor and methods of use
US7761165B1 (en) 2005-09-29 2010-07-20 Boston Scientific Neuromodulation Corporation Implantable stimulator with integrated plastic housing/metal contacts and manufacture and use
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
US7550053B2 (en) 2006-01-26 2009-06-23 Ilh, Llc Catheters with lubricious linings and methods for making and using them
US20070095661A1 (en) 2005-10-31 2007-05-03 Yi Wang Method of making, and, analyte sensor
US8182444B2 (en) 2005-11-04 2012-05-22 Medrad, Inc. Delivery of agents such as cells to tissue
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US20070173706A1 (en) 2005-11-11 2007-07-26 Isense Corporation Method and apparatus for insertion of a sensor
US7918975B2 (en) 2005-11-17 2011-04-05 Abbott Diabetes Care Inc. Analytical sensors for biological fluid
US8815175B2 (en) 2005-11-30 2014-08-26 Abbott Diabetes Care Inc. Integrated meter for analyzing biological samples
US7922971B2 (en) 2005-11-30 2011-04-12 Abbott Diabetes Care Inc. Integrated meter for analyzing biological samples
EP1961381A4 (en) 2005-12-01 2011-04-13 Arkray Inc INTEGRATED SENSOR / LANZETTE DEVICE AND METHOD FOR COLLECTING BODY FLUID WITH THEREOF
US8515518B2 (en) 2005-12-28 2013-08-20 Abbott Diabetes Care Inc. Analyte monitoring
CA2636034A1 (en) 2005-12-28 2007-10-25 Abbott Diabetes Care Inc. Medical device insertion
WO2007089738A2 (en) 2006-01-26 2007-08-09 The Regents Of The University Of Michigan Microelectrode with laterally extending platform for reduction of tissue encapsulation
US7736310B2 (en) 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
WO2007095093A2 (en) 2006-02-09 2007-08-23 Deka Products Limited Partnership Pumping fluid delivery systems and methods using force application assembly
US7826879B2 (en) 2006-02-28 2010-11-02 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US7811430B2 (en) 2006-02-28 2010-10-12 Abbott Diabetes Care Inc. Biosensors and methods of making
EP1991110B1 (en) 2006-03-09 2018-11-07 DexCom, Inc. Systems and methods for processing analyte sensor data
US7887682B2 (en) 2006-03-29 2011-02-15 Abbott Diabetes Care Inc. Analyte sensors and methods of use
US7801582B2 (en) 2006-03-31 2010-09-21 Abbott Diabetes Care Inc. Analyte monitoring and management system and methods therefor
US20070233013A1 (en) 2006-03-31 2007-10-04 Schoenberg Stephen J Covers for tissue engaging members
US7653425B2 (en) 2006-08-09 2010-01-26 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US7559899B2 (en) 2006-04-12 2009-07-14 Salutron, Inc. Power saving techniques for continuous heart rate monitoring
WO2007140783A2 (en) 2006-06-07 2007-12-13 Unomedical A/S Inserter for transcutaneous sensor
US7920907B2 (en) 2006-06-07 2011-04-05 Abbott Diabetes Care Inc. Analyte monitoring system and method
US7909842B2 (en) 2006-06-15 2011-03-22 Abbott Diabetes Care Inc. Lancing devices having depth adjustment assembly
US7866026B1 (en) 2006-08-01 2011-01-11 Abbott Diabetes Care Inc. Method for making calibration-adjusted sensors
JP2009545342A (ja) 2006-08-02 2009-12-24 ウノメディカル アクティーゼルスカブ 挿入デバイス
US7789857B2 (en) 2006-08-23 2010-09-07 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US8234706B2 (en) 2006-09-08 2012-07-31 Microsoft Corporation Enabling access to aggregated software security information
US7831287B2 (en) 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8298142B2 (en) 2006-10-04 2012-10-30 Dexcom, Inc. Analyte sensor
US8449464B2 (en) 2006-10-04 2013-05-28 Dexcom, Inc. Analyte sensor
US8275438B2 (en) 2006-10-04 2012-09-25 Dexcom, Inc. Analyte sensor
US8478377B2 (en) 2006-10-04 2013-07-02 Dexcom, Inc. Analyte sensor
US8447376B2 (en) 2006-10-04 2013-05-21 Dexcom, Inc. Analyte sensor
US8562528B2 (en) 2006-10-04 2013-10-22 Dexcom, Inc. Analyte sensor
US8158081B2 (en) 2006-10-31 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring devices
WO2008065646A1 (en) 2006-11-28 2008-06-05 Medingo Ltd. An insertion device and method for inserting a subcutaneously insertable element into a body
US7946985B2 (en) 2006-12-29 2011-05-24 Medtronic Minimed, Inc. Method and system for providing sensor redundancy
US20100113897A1 (en) 2007-03-19 2010-05-06 Bayer Health Care Llc Continuous analyte monitoring assembly and methods of using the same
US20080269673A1 (en) 2007-04-27 2008-10-30 Animas Corporation Cellular-Enabled Medical Monitoring and Infusion System
WO2008133702A1 (en) 2007-04-30 2008-11-06 Medtronic Minimed, Inc. Needle inserting and fluid flow connection for infusion medium delivery system
EP2146760B1 (en) 2007-04-30 2018-10-10 Medtronic MiniMed, Inc. Reservoir filling, bubble management, and infusion medium delivery systems and methods with same
DE102007026083A1 (de) 2007-05-25 2008-11-27 Haselmeier S.A.R.L. Injektionsgerät
WO2008150917A1 (en) 2007-05-31 2008-12-11 Abbott Diabetes Care, Inc. Insertion devices and methods
US20080306434A1 (en) 2007-06-08 2008-12-11 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20080319327A1 (en) 2007-06-25 2008-12-25 Triage Wireless, Inc. Body-worn sensor featuring a low-power processor and multi-sensor array for measuring blood pressure
US8002752B2 (en) 2007-06-25 2011-08-23 Medingo, Ltd. Protector apparatus
US8641618B2 (en) 2007-06-27 2014-02-04 Abbott Diabetes Care Inc. Method and structure for securing a monitoring device element
NZ582226A (en) 2007-07-18 2011-12-22 Unomedical As Insertion device with a pivoting action from a first to a second position and longitudinal action to a third position in the direction of insertion.
US8303545B2 (en) 2007-09-07 2012-11-06 Stat Medical Devices, Inc. Infusion device and method of using and making the same
EP2200677A1 (en) 2007-09-17 2010-06-30 ICU Medical, Inc. Insertion devices for infusion devices
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
EP2060284A1 (en) 2007-11-13 2009-05-20 F.Hoffmann-La Roche Ag Medical injection device having data input means and a pivotable display
US8290559B2 (en) 2007-12-17 2012-10-16 Dexcom, Inc. Systems and methods for processing sensor data
US20090299155A1 (en) 2008-01-30 2009-12-03 Dexcom, Inc. Continuous cardiac marker sensor system
CN101970033A (zh) 2008-02-08 2011-02-09 优诺医疗有限公司 包括插入件、套管部和基部的组件
MX2010007983A (es) 2008-02-08 2010-08-06 Unomedical As Ensamble de insertador.
CA2715624A1 (en) 2008-02-20 2009-08-27 Dexcom, Inc. Continuous medicament sensor system for in vivo use
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
US8122783B2 (en) 2008-02-22 2012-02-28 Sauer-Danfoss Inc. Joystick and method of manufacturing the same
US8396528B2 (en) 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
US20090242399A1 (en) 2008-03-25 2009-10-01 Dexcom, Inc. Analyte sensor
US20090247856A1 (en) 2008-03-28 2009-10-01 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US20090259118A1 (en) 2008-03-31 2009-10-15 Abbott Diabetes Care Inc. Shallow Implantable Analyte Sensor with Rapid Physiological Response
US9924898B2 (en) 2008-04-15 2018-03-27 Becton, Dickinson And Company Flash activated passive shielding needle assembly
WO2010003886A1 (en) 2008-07-07 2010-01-14 Unomedical A/S Inserter for transcutaneous device
US8560039B2 (en) 2008-09-19 2013-10-15 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US20100331644A1 (en) 2008-11-07 2010-12-30 Dexcom, Inc. Housing for an intravascular sensor
US20100198034A1 (en) 2009-02-03 2010-08-05 Abbott Diabetes Care Inc. Compact On-Body Physiological Monitoring Devices and Methods Thereof
US20100198033A1 (en) 2009-02-05 2010-08-05 Peter Krulevitch Flexible indwelling biosensor, flexible indwelling biosensor insertion device, and related methods
US9446194B2 (en) 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
EP2272553A1 (en) 2009-06-29 2011-01-12 Unomedical A/S Inserter Assembly
US20110004085A1 (en) 2009-04-30 2011-01-06 Dexcom, Inc. Performance reports associated with continuous sensor data from multiple analysis time periods
US10376213B2 (en) 2009-06-30 2019-08-13 Waveform Technologies, Inc. System, method and apparatus for sensor insertion
US20110027458A1 (en) 2009-07-02 2011-02-03 Dexcom, Inc. Continuous analyte sensors and methods of making same
US8932256B2 (en) 2009-09-02 2015-01-13 Medtronic Minimed, Inc. Insertion device systems and methods
EP2482724A2 (en) 2009-09-30 2012-08-08 Dexcom, Inc. Transcutaneous analyte sensor
US9041730B2 (en) 2010-02-12 2015-05-26 Dexcom, Inc. Receivers for analyzing and displaying sensor data
GB201003581D0 (en) 2010-03-04 2010-04-21 Bacon Raymond J Medicament dispenser
KR101553741B1 (ko) 2010-04-05 2015-09-16 카즈 유럽 에스에이 의료 탐침용 삽입 여부 검출기
WO2011163519A2 (en) 2010-06-25 2011-12-29 Dexcom, Inc. Systems and methods for communicating sensor data between communication devices
US10231653B2 (en) 2010-09-29 2019-03-19 Dexcom, Inc. Advanced continuous analyte monitoring system
EP2632334B1 (en) 2010-10-27 2020-09-09 Dexcom, Inc. Continuous analyte monitor data recording device operable in a blinded mode

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5957854A (en) * 1993-09-04 1999-09-28 Besson; Marcus Wireless medical diagnosis and monitoring equipment
US5948006A (en) * 1998-10-14 1999-09-07 Advanced Bionics Corporation Transcutaneous transmission patch
CN1499949A (zh) * 2000-12-19 2004-05-26 ����˹ҽ�����޹�˾ 分析物测量
US6560471B1 (en) * 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10143396B2 (en) 2012-07-27 2018-12-04 University Of Southampton Apparatus for use for providing information on at least one muscle in a patient
WO2015106489A1 (zh) * 2014-01-20 2015-07-23 上海移宇科技有限公司 无导管药物流体输注器件
US9861741B2 (en) 2014-01-20 2018-01-09 Medtrum Technologies Inc. Tubeless fluid delivery device
CN106860956A (zh) * 2017-03-17 2017-06-20 苏州艾伊帕微动力科技有限公司 一种柔性微泵驱动的慢性病便携式自动监测/给药装置

Also Published As

Publication number Publication date
US20230414870A1 (en) 2023-12-28
RU2009119430A (ru) 2010-11-27
EP2083878A4 (en) 2010-04-28
US20160151569A1 (en) 2016-06-02
CN101528282A (zh) 2009-09-09
WO2008051924A2 (en) 2008-05-02
MX2009004322A (es) 2009-08-24
US20120190952A1 (en) 2012-07-26
JP2014030745A (ja) 2014-02-20
JP5727555B2 (ja) 2015-06-03
US20080119707A1 (en) 2008-05-22
US9259175B2 (en) 2016-02-16
US10363363B2 (en) 2019-07-30
US11724029B2 (en) 2023-08-15
AU2007309070B2 (en) 2013-05-23
RU2481579C2 (ru) 2013-05-10
AU2007309070A1 (en) 2008-05-02
US20190298921A1 (en) 2019-10-03
BRPI0718065A2 (pt) 2014-07-08
EP2083878A2 (en) 2009-08-05
JP2010507457A (ja) 2010-03-11
WO2008051924A3 (en) 2008-07-03
CA2667305A1 (en) 2008-05-02

Similar Documents

Publication Publication Date Title
CN101528282B (zh) 用于流体递送和监测体内分析物的柔性贴片
US20240033429A1 (en) Integrated analyte sensor and infusion device and methods therefo
US20200029902A1 (en) Body-wearable medical device
US8942778B2 (en) Analyte monitoring sensor system for monitoring a constituent in body tissue
CN102711898B (zh) 分析物监控和流体分配系统
CN101563022B (zh) 带体内电化学分析物感测的流体传输
CN102307518B (zh) 分析物传感器和用于传感器插入的设备
CN101180093A (zh) 用于提供结合的药剂输液以及分析物监测系统的方法和系统
CN113117181A (zh) 集成型闭环人工胰腺
US11395608B2 (en) Medical sensor system, in particular continuous glucose monitoring system
US20220347384A1 (en) Wired continuous glucose monitoring infusion set

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant