CN101507826B - Preparation method of medical quick imbibition foam material - Google Patents

Abstract

The invention relates to a method for preparing a medical quick liquid-absorbing foam material. The method comprises the steps of well mixing polyvinyl alcohol aqueous solution, aldehyde and a pore-forming agent, adding acid to the mixture, continuing to stir the mixture, pouring the mixed solution into a die, curing and molding the mixed solution, washing and drying the obtained product and obtaining a target object. The material has abundant mutually communicated opening structures through a method of using mechanical foaming together with the pore-forming agent. The prepared material is good in biological compatibility and excellent in hydrophilcity, has the liquid-absorbing capability much higher than common cotton yarn and paper, has the capability of quickly absorbing a large amountof distilled water, physiological saline and urine, turns into soft tenacious elastic sponge after absorbing liquid, is resistant to heat and ultraviolet radiation, and can be disinfected in a plurality of ways. The prepared material is a rigid foam material in a dry state, is a spongy material in a wet state, has the apparent density of between 0.04 and 0.09 g/cm<3> and the liquid-absorbing ratio of between 1,800 and 2,800 percent, and can be applied to medical operations.

Description

A kind of method for preparing of medical quick imbibition foam material

Technical field

The invention belongs to the medical macromolecular materials field, relate to a kind of method for preparing of medical quick imbibition foam material.

Background technology

As medical material, no matter as Wound dressing, still, in operation process, all need in time sop up the liquid that oozes out as cave type wound implant, and hemostasis in time, it is also unsatisfactory to use traditional medical material (like gauze, cotton balls etc.) at present.

The structure of foam class dressing has porous; Liquid had bigger absorptive capacity; Can see through oxygen and carbon dioxide; Material is controlled by steam transhipment and mechanism of absorption the processing of Wound exudate, and wound is had good protective action, and what this type of dressing use was maximum at present is polyurethane and polyvinyl alcohol foam.

Chinese patent CN1741824 discloses polyurethane foam dressing and the manufacturing approach thereof that is used for the wound implant, and this material has 5-20 absorbance doubly, the juice of can the fast Absorption wound discharging.The shortcoming of this material is after absorbing liquid, not have certain volumetric expansion ability, can not give wound with certain pressure, thereby can not play the effect of quick-acting haemostatic powder, and this material preparation process is complicated in addition, and its large-scale production and application are restricted.

Chinese patent CN1095387 and the disclosed polyvinyl alcohol foam material of Chinese patent CN1557872 are raw material with polyvinyl alcohol and formaldehyde, under acid catalysis, prepare.But owing to adopting sodium bicarbonate or magnesium metal, aluminum, zinc powder is foaming agent, react too violent, so foaming process is restive, and foam structure is inhomogeneous, influences its imbibition effect, and this patent is not reported the result of rate of liquid aspiration.

Summary of the invention

In order to solve the problem of prior art, the invention provides that a kind of preparation technology is simple, the method for preparing of medical quick imbibition foam material with low cost.Contain abundant hydroxyl in the described medical quick imbibition foam material, so have excellent hydrophilic; Simultaneously, the present invention adopts the method that machinery is got blisters and pore former cooperatively interacts to give the open-celled structure of the abundant mutual perforation of described foamed materials, makes it have imbibition ability fast.Medical quick imbibition foam material of the present invention is the polyvinyl alcohol foam material; This material all has a large amount of and the ability of fast Absorption to distilled water, normal saline, urine, can be applied to surgical operation liner, department of otorhinolaryngology and other microsurgery fields such as hemostatic material, Medical dressing of sucking blood.

For reaching the foregoing invention purpose, the present invention is to be primary raw material with the polyethylene alcohols and aldehydes, is that adjuvant prepares the porous foamed materials with acid, surfactant, pore former.

The technical scheme that the present invention adopts may further comprise the steps:

Is the mass percent proportioning 4-8% polyvinyl alcohol, 65-75% water, and 1-4% aldehyde, 1-2% surfactant and 1-2% pore former are mixed into uniform liquid; This liquid is poured in the agitator, stirred 10-30 minute, adding the mass percent proportioning again is 15-25% acid; Continue to stir 20-40 minute, aforesaid liquid is poured in the acidproof mould, at 30-60 ℃ of solidifying and setting 4-40 hour; Washing, drying obtains target product;

Described polyvinyl alcohol alcoholysis degree is greater than 88%, and the degree of polymerization is 1500-2000;

Described aldehyde is formaldehyde, paraformaldehyde or their mixture;

Described acid is sulphuric acid or phosphoric acid;

Described surfactant is anionic, dodecyl sodium sulfate or nekal; Perhaps be one or more of non-ionic surfactant polyoxyethylene sorbitan mono-laurate, polyoxyethylene 20 sorbitan monopalmitate, polyoxyethylene 20 sorbitan monostearate and polyoxyethylene 20 sorbitan monooleate;

Described pore former is potato starch or corn starch.

Beneficial effect: the present invention adopts the method that machinery is got blisters and pore former cooperatively interacts to give the open-celled structure of the abundant mutual perforation of material, and preparation technology is simple, and process is controlled easily.

The medical quick imbibition material of the inventive method preparation has extremely good imbibition ability, and outstanding feature is all to have quick and a large amount of absorbability for distilled water, normal saline, urine.Have during hygrometric state and the no adhesion of tissue, soft characteristics such as no fibre shedding both can be used as the wound clean material and tough, absorbed wound sepage, pus and blood, also can be used as dressing, kept the wound circumference moist environment, promoted the healing of wound.

The preparation the foamed materials dry state time be hard foam, be softish spongy material during hygrometric state.Show from the mensuration result of table 1 to table 4: this foamed materials is apparent density 0.04-0.09g/cm ³, imbibition (distilled water, normal saline, urine) rate is up to 1800-2800%, at most only need 125 seconds when vertical suction range reaches 50mm, makes this material can be used as good medical grade drain material.

Utilize the medical quick imbibition material of the inventive method preparation to have excellent biological compatibility; To skin nonirritant and sensitization; Can be applicable to Medical dressing, surgical operation liner, department of otorhinolaryngology and other microsurgery fields such as hemostatic material of sucking blood, have wide medical application prospect.

The specific embodiment

Embodiment 1

Batch mixes: the polyvinyl alcohol of 65 the gram degree of polymerization 1700, alcoholysis degrees 98% is dissolved in and is made into mass percent in the 950 gram hot water is 5% solution; Add 10 gram sodium lauryl sulphates, 5 gram nekals, paraformaldehyde 30 grams; Corn starch 30 grams; Mix homogeneously is poured in the agitator, stirs 10 minutes; Adding mass percent again is 350 milliliters in 50% sulphuric acid, continues to stir 40 minutes.Pour aforesaid liquid into acidproof mould, put into calorstat, 40 hours curing moldings of 30 ℃ of reactions, washing, drying obtains target product.

Physical property and method of testing:

Pick up: the initial weight (A) of measuring the foamed materials with a certain size afterwards; Foam sample was soaked 10 minutes in distilled water, normal saline, urine respectively; Be placed on the water on drainage screen last 30 second of scumming surface; And weigh (B), the pick up of foamed materials is calculated with following formula: pick up (%)=(B-A)/A * 100%.This process repeats 3 times, and the mean value calculation of 3 measured values is as pick up.

Vertical rate of liquid aspiration: vertical absorbent is that a kind of showing can be with the standard of measurement of the ability of the direction fluid transfer opposite with gravity.Foam sample with 2cm * 20cm * 0.3cm size vertically immerses in distilled water, normal saline, the urine respectively, picks up counting the time that the working sample liquid draw is spent to apart from liquid level 50mm height the time.This process repeats 3 times, and the mean value calculation of 3 measured values is as vertical rate of liquid aspiration.

Test result is as shown in table 1

Embodiment 2

Batch mixes: the polyvinyl alcohol of 100 the gram degree of polymerization 1500, alcoholysis degrees 98% is dissolved in and is made into mass percent in the 900 gram hot water is 10% solution; Add 10 gram polyoxyethylene 20 sorbitan monolaurates; 10 gram dodecylbenzene sodium sulfonate, 65 milliliters of formalins, adding 25 KEMA bell sweet potato starch; Mix homogeneously is poured in the agitator, stirs 20 minutes; Adding mass percent again is 500 milliliters in 50% sulphuric acid, continues to stir 20 minutes.Pour aforesaid liquid into acidproof mould, put into calorstat, 24 hours curing moldings of 40 ℃ of reactions, washing, drying obtains target product.

Physical property and method of testing: with embodiment 1

Test result is as shown in table 2:

Embodiment 3

Batch mixes: the polyvinyl alcohol of 300 the gram degree of polymerization 2000, alcoholysis degrees 88% is dissolved in and is made into mass percent in the 2200 gram hot water is 12% solution; Add 70 gram polyoxyethylene sorbitan list palm fibre eleostearates, 100 milliliters of formalins, paraformaldehyde 15 grams, 85 gram corn starchs, mix homogeneously is poured in the agitator, stirs 25 minutes: adding mass percent again is 150 milliliters of 45% phosphatase 11s; Continue to stir 25 minutes: pour aforesaid liquid into acidproof mould; Put into calorstat, 10 hours curing moldings of 50 ℃ of reactions, washing; Drying obtains target product.

Physical property and method of testing: with embodiment 1

Test result is as shown in table 3:

Apparent density

Pick up (%)

Rate of liquid aspiration (second)

(g/cm 3)

Distilled water

Normal saline

Urine

Distilled water

Normal saline

Urine

?0.073

?2150

?2130

?2150

?95

?90

?100

Embodiment 4

Batch mixes: the polyvinyl alcohol of the 100 gram degree of polymerization 1700, alcoholysis degree 95% is dissolved in the solution that is made into mass percent 12% in the 733 gram hot water; Add 15 gram polyoxyethylene 20 sorbitan monostearates, 5 gram polyoxyethylene 20 sorbitan monooleates, formalin 60ml, corn starch 35 grams; Mix homogeneously is poured in the agitator, stirs 30 minutes; Adding mass percent again is 600 milliliters in 50% sulphuric acid, continues to stir 20 minutes.Pour aforesaid liquid into acidproof mould, put into calorstat, 4 hours curing moldings of 60 ℃ of reactions, washing, drying obtains target product.

Physical property and method of testing: with embodiment 1

Test result is as shown in table 4

Claims (1)

1. the method for preparing of a medical quick imbibition foam material, it is characterized in that step and condition are following: is the mass percent proportioning 4-8% polyvinyl alcohol, 65-75% water; 1-4% aldehyde, 1-2% surfactant and 1-2% pore former are mixed into uniform liquid, this liquid is poured in the agitator stirred 10-30 minute; Adding the mass percent proportioning again is 15-25% acid, continues to stir 20-40 minute, and aforesaid liquid is poured in the acidproof mould; At 30-60 ℃ of solidifying and setting 4-40 hour; Washing, drying obtains target product;

Described polyvinyl alcohol alcoholysis degree is greater than 88%, and the degree of polymerization is 1500-2000;

Described aldehyde is formaldehyde, paraformaldehyde or their mixture;

Described acid is sulphuric acid or phosphoric acid;

Described surfactant is anionic, dodecyl sodium sulfate or nekal; Perhaps be one or more of non-ionic surfactant polyoxyethylene sorbitan mono-laurate, polyoxyethylene 20 sorbitan monopalmitate, polyoxyethylene 20 sorbitan monostearate and polyoxyethylene 20 sorbitan monooleate;

Described pore former is potato starch or corn starch.