CN101450336B - Fluid separation method and device - Google Patents
Fluid separation method and device Download PDFInfo
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- CN101450336B CN101450336B CN2007101967591A CN200710196759A CN101450336B CN 101450336 B CN101450336 B CN 101450336B CN 2007101967591 A CN2007101967591 A CN 2007101967591A CN 200710196759 A CN200710196759 A CN 200710196759A CN 101450336 B CN101450336 B CN 101450336B
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- fluid
- storagetank
- separation device
- district
- collecting region
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Abstract
The invention discloses a fluid separation device and a fluid separation method for using the fluid separation device. The fluid separation device comprises a body, a storage tank, a liquid inlet groove and a separating unit, wherein the storage tank is formed in the center of the body; the liquid inlet groove is formed on the body and communicated with the storage tank; the separating unit is formed on the body and communicated with the liquid inlet groove; the separating unit comprises a stacking area, a collecting area and a retaining wall; the collecting area is positioned between the stacking area and the storage tank; and the retaining wall is formed between the collecting area and the stacking area.
Description
Technical field
The present invention relates to a kind of fluid separation device, particularly a kind of fluid separation device that is used for separating blood.The invention still further relates to the separation of fluids that uses this fluid separation device.
Background technology
Its structure of known fluid separation device is comparatively complicated usually, and for example the fluid separation device that disclosed of U.S. Pat 6548788 has the design of little valve, in order to flowing of control fluid on its card casket.But because little valve must be made with micro-processing technology, therefore known fluid separation device also can't be made through the mode of plastic rubber ejaculate molding, thereby cost is higher.
Same, U.S. Pat 5061381 and US 5089417 have also disclosed other forms of fluid separation device, and its structure is too complicated, so manufacturing cost is higher.
Summary of the invention
A kind of fluid separation device that the present invention promptly provides for desire solves the problem of known technology comprises body, storagetank, feed liquor raceway groove and separative element.Storagetank is formed at this body center.The feed liquor channel shape is formed on this body, and is communicated with this storagetank.Separative element is formed on this body, and is communicated with this feed liquor raceway groove.Separative element comprises heaps district, collecting region and barrier.Collecting region is heaped between district and this storagetank at this.Barrier is formed between this collecting region and this heap district.
Use fluid separation device of the present invention, can better simply structure and lower cost, accomplish the work that fluid separates fast.
Description of drawings
Fig. 1 a is the fluid separation device that shows first embodiment of the invention;
Fig. 1 b is the A part enlarged drawing that shows among Fig. 1 a;
Fig. 2 a-2c is the fluid separation process that shows the fluid separation device of first embodiment;
Fig. 2 d is the B part enlarged drawing that shows among Fig. 2 c;
Fig. 3 a is the variation that shows first embodiment of the invention;
Fig. 3 b is the C part enlarged drawing that shows among Fig. 3 a;
Fig. 4 a, 4b are the fluid separation devices that shows second embodiment of the invention; And
Fig. 5 a-5c is the fluid separation process that shows the fluid separation device of second embodiment.
Description of reference numerals
10～fluid, 11～first fluid composition
12～the second fluid compositions 100,200～fluid separation device
110～body, 111～first surface
120～storagetank, 121～spiral groove
130～separative element, 131～collecting region
132～heap and distinguish 133～barrier
134～guide groove, 140～feed liquor raceway groove
150～deaeration channel, 210～the first bodies
211～spiral groove 212～the first connects groove
220～the second bodies, 221～the first separation chambers
222～the second connect groove 223～the second separation chambers
224～capillary, 231～the first exhaust trench
232～the second exhaust trench 233～the 3rd exhaust trench
240～surplus liquid chamber
The specific embodiment
With reference to Fig. 1 a, it is the fluid separation device 100 that shows first embodiment of the invention, comprises body 110, storagetank 120, separative element 130, feed liquor raceway groove 140 and deaeration channel 150.This body 110 is rounded.This storagetank 120 is rounded, is formed at this body 110 central authorities.Separative element 130 is formed at the edge of this body 110, with equally spaced mode around this storagetank 120.Feed liquor raceway groove 140 is formed on this body 110, and is communicated with this storagetank 120 and this separative element 130.This deaeration channel 150 is formed on this body 110, and is communicated with this storagetank 120 and this separative element 130.
With reference to Fig. 1 b, it is the A part enlarged drawing that shows among Fig. 1 a.This body 110 comprises first surface 111.This separative element 130 comprises collecting region 131, heaps district 132 and barrier 133.Collecting region 131 is heaped between district 132 and this storagetank 120 at this.Barrier 133 is formed between this collecting region 131 and this heap district 132.The volume of this collecting region 131 is heaped the volume in district 132 less than this.This volumetric ratio of heaping district 132 and this collecting region 131 is between 1: 1 to 2: 1.The depth d of this barrier 133 and the depth ratio of this collecting region are approximately between 1/3～1/6.This heap district 132 in the width W 2 of circumferencial direction greater than the width W 1 of this collecting region 131 in circumferencial direction.This feed liquor raceway groove 140 is positioned at this barrier 133 tops with the link position of this separative element 130.150 of deaeration channel are communicated with this collecting region 131 and this storagetank 120.
With reference to Fig. 2 a-2c is the fluid separation process that shows fluid separation device 100.At first, shown fluid (blood) 10 centre among this storagetank 120 of being instiled like Fig. 2 a.Then, with reference to Fig. 2 b and 2c figure, this fluid separation device 100 is a pivot with storagetank 120, along the inverse clock rotation, so that this fluid (blood) 10 is pushed among this separative element 130 through centrifugal force.With reference to Fig. 2 d; It is the B part enlarged drawing that shows among Fig. 2 c, wherein, and after this fluid (blood) 10 separated completion; The first fluid composition (blood cell) 11 of this fluid 10 is collected in this heap district 132, and second fluid composition (blood plasma) 12 of this fluid 10 is collected in this collecting region 131.
With reference to Fig. 3 a, it is the variation 100 ' that shows first embodiment of the invention, and wherein, this storagetank 120 also comprises spiral groove 121, is formed at the bottom of this storagetank 120, carries out quantitatively in order to convection cell 10.Simultaneously, with reference to Fig. 3 b, it is the C part enlarged drawing that shows among Fig. 3 a, and the top of this barrier 133 more is provided with a plurality of guide grooves 134, and these guide grooves 134 see through these first fluid composition (blood cell) 11 entering of capillarity guiding should heap district 132.
With reference to Fig. 4 a, 4b, it is the fluid separation device 200 that shows second embodiment of the invention, comprises first body 210 and second body 220.First body 210 comprises that spiral groove 211 and first connects groove 212.This first connection groove 212 is communicated with the bottom of these spiral grooves 211, and runs through this first body 210.Second body 220 comprises that first separation chamber 221, second connects groove 222, second separation chamber 223 and capillary 224.First separation chamber 221 is communicated with this first connection groove 222.Second connects groove 222 is communicated with this first separation chamber 221, and wherein, these second connection ditch, 222 grooves ringwise.Capillary 224 is communicated with these second separation chambers 223 and this second connection groove 222.
With reference to Fig. 5 a-5c, it is the fluid separation process that shows fluid separation device 200.At first, this fluid (blood) 10 is injected among this spiral groove 211.Then, with reference to 5b figure, this fluid separation device 200 rotates with first rotating speed towards first direction (clockwise); At this moment; This fluid 10 flows in this first separation chamber 221, and in this first separation chamber 221, this first fluid composition (blood cell) 11 separates with this second fluid composition (blood plasma) 12.At last, with reference to 5c figure, this fluid separation device 200 rotates with second rotating speed towards second direction (counterclockwise); At this moment; This second fluid composition (blood plasma) 12 flows into this second connection groove 222 from this first separation chamber 221, and through capillary 224, flows into second separation chamber 223; Unnecessary second fluid composition (blood plasma) 12 can get into surplus liquid chamber 240, and this first fluid composition (blood cell) 11 is then stayed in this first separation chamber 221.
This first rotating speed is greater than this second rotating speed.When this fluid 10 flowed into this first separation chamber 221, this second separation chamber 222 and this surplus liquid chamber 240, the air in this first separation chamber 221, this second separation chamber 222 and this surplus liquid chamber 240 was discharged by this first exhaust trench 231, this second exhaust trench 232 and the 3rd exhaust trench 233.
Use fluid separation device of the present invention, can better simply structure and lower cost, accomplish the work that fluid separates fast.
Though the present invention discloses as above with concrete preferred embodiment; Right its is not in order to limit the present invention; Those skilled in the art are not breaking away from the spirit and scope of the present invention; Still can do a little change and retouching, so protection scope of the present invention is when looking being as the criterion that accompanying Claim defines.
Claims (11)
1. fluid separation device comprises:
Body;
Storagetank is formed on this body;
The feed liquor raceway groove is formed on this body, and is communicated with this storagetank;
Separative element is formed on this body, and is communicated with this feed liquor raceway groove, comprising:
Heap the district;
Collecting region is heaped between district and this storagetank at this; And
Barrier; Be formed between this collecting region and this heap district, wherein, the link position in the heap district of this feed liquor raceway groove and this separative element is positioned at this barrier top; When this fluid separation device separation of the fluid; According to the difference of proportion, the first fluid composition of this fluid is collected in this heap district, and second fluid composition of this fluid is collected in this collecting region; And
Deaeration channel is communicated with this collecting region and this storagetank.
2. fluid separation device as claimed in claim 1, wherein, the volume of this collecting region is heaped the volume in district less than this.
3. fluid separation device as claimed in claim 1, wherein, this volumetric ratio of heaping district and this collecting region is between 1: 1 to 2: 1.
4. fluid separation device as claimed in claim 1, wherein, the degree of depth of this barrier and the depth ratio of this collecting region are between 1/3～1/6.
5. fluid separation device as claimed in claim 1, wherein, this storagetank comprises spiral groove, is formed at this storagetank bottom.
6. fluid separation device as claimed in claim 1, wherein, this barrier also comprises a plurality of guide grooves, is formed at the top of this barrier.
7. fluid separation device as claimed in claim 1, wherein, this fluid is a blood, and this first fluid composition is a blood cell, and this second fluid composition is a blood plasma.
8. separation of fluids in order to the first fluid composition in the separation of the fluid and second fluid composition, comprising:
Fluid separation device as claimed in claim 1 is provided; And
With this storagetank is that pivot is rotated, to separate this first fluid composition and this second fluid composition.
9. fluid separation device comprises:
Body;
Storagetank is formed on this body;
A plurality of feed liquor raceway grooves are formed on this body, and are communicated with this storagetank; And
A plurality of separative elements are formed on this body, are communicated with this a plurality of feed liquor raceway grooves, and arrange around this storagetank in regular turn, and each separative element is communicated with a feed liquor raceway groove, comprising:
Heap the district;
Collecting region is heaped between district and this storagetank at this; And
Barrier; Be formed between this collecting region and this heap district, wherein, the link position in the heap district of this feed liquor raceway groove and this separative element is positioned at this barrier top; When this fluid separation device separation of the fluid; According to the difference of proportion, the first fluid composition of this fluid is collected in this heap district, and second fluid composition of this fluid is collected in this collecting region; And a plurality of deaeration channel, be communicated with this collecting region and this storagetank of each separative element respectively.
10. fluid separation device as claimed in claim 9, wherein, these a plurality of separative elements are to arrange with equally spaced mode.
11. a separation of fluids in order to the first fluid composition in the separation of the fluid and second fluid composition, comprising:
Fluid separation device as claimed in claim 9 is provided; And
With this storagetank is that pivot is rotated, to separate this first fluid composition and this second fluid composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101967591A CN101450336B (en) | 2007-12-06 | 2007-12-06 | Fluid separation method and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101967591A CN101450336B (en) | 2007-12-06 | 2007-12-06 | Fluid separation method and device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101450336A CN101450336A (en) | 2009-06-10 |
| CN101450336B true CN101450336B (en) | 2012-02-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101967591A Active CN101450336B (en) | 2007-12-06 | 2007-12-06 | Fluid separation method and device |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061381A (en) * | 1990-06-04 | 1991-10-29 | Abaxis, Inc. | Apparatus and method for separating cells from biological fluids |
| CN1321105A (en) * | 1999-09-03 | 2001-11-07 | 巴克斯特国际公司 | Systems and methods for separating blood in rotating field |
| US6548788B2 (en) * | 1997-05-23 | 2003-04-15 | Tecan Trading Ag | Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system |
| CN1921948A (en) * | 2003-12-31 | 2007-02-28 | 巴克斯特国际公司 | Separation apparatus and method |
-
2007
- 2007-12-06 CN CN2007101967591A patent/CN101450336B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061381A (en) * | 1990-06-04 | 1991-10-29 | Abaxis, Inc. | Apparatus and method for separating cells from biological fluids |
| US6548788B2 (en) * | 1997-05-23 | 2003-04-15 | Tecan Trading Ag | Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system |
| CN1321105A (en) * | 1999-09-03 | 2001-11-07 | 巴克斯特国际公司 | Systems and methods for separating blood in rotating field |
| CN1921948A (en) * | 2003-12-31 | 2007-02-28 | 巴克斯特国际公司 | Separation apparatus and method |
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| Publication number | Publication date |
|---|---|
| CN101450336A (en) | 2009-06-10 |
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