CN101340890A - 乙醇变性剂 - Google Patents
乙醇变性剂 Download PDFInfo
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- CN101340890A CN101340890A CNA2006800477921A CN200680047792A CN101340890A CN 101340890 A CN101340890 A CN 101340890A CN A2006800477921 A CNA2006800477921 A CN A2006800477921A CN 200680047792 A CN200680047792 A CN 200680047792A CN 101340890 A CN101340890 A CN 101340890A
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- chlorhexidine
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 150
- 239000003398 denaturant Substances 0.000 title claims abstract description 42
- 239000000203 mixture Substances 0.000 claims abstract description 34
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940123208 Biguanide Drugs 0.000 claims abstract description 8
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 150000003839 salts Chemical class 0.000 claims abstract description 4
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical class CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 claims description 9
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 8
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 229950010221 alexidine Drugs 0.000 claims description 6
- 150000004283 biguanides Chemical class 0.000 claims description 3
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 claims description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical class F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 2
- WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 claims description 2
- 229960001884 chlorhexidine diacetate Drugs 0.000 claims description 2
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 claims description 2
- 229960001731 gluceptate Drugs 0.000 claims description 2
- KWMLJOLKUYYJFJ-VFUOTHLCSA-N glucoheptonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O KWMLJOLKUYYJFJ-VFUOTHLCSA-N 0.000 claims description 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims description 2
- 229940001447 lactate Drugs 0.000 claims description 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 2
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims 1
- 229960004329 metformin hydrochloride Drugs 0.000 claims 1
- 229940075894 denatured ethanol Drugs 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 description 52
- KUXUALPOSMRJSW-IFWQJVLJSA-N 2-[6-[[amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 KUXUALPOSMRJSW-IFWQJVLJSA-N 0.000 description 18
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- 230000000052 comparative effect Effects 0.000 description 11
- 235000019640 taste Nutrition 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000001476 alcoholic effect Effects 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 235000019658 bitter taste Nutrition 0.000 description 5
- 230000007850 degeneration Effects 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 2
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 2
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 description 2
- 229920002596 Polyethylene Glycol 900 Polymers 0.000 description 2
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- 229940043265 methyl isobutyl ketone Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
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- 239000000443 aerosol Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- -1 biguanide compound Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 125000005909 ethyl alcohol group Chemical group 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960003105 metformin Drugs 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Abstract
提供了一种变性乙醇组合物，所述组合物基本上由下列组分组成：乙醇和变性剂，所述变性剂选自由下列物质组成的组：氯己定及其盐、双胍类和两种或更多种上述物质的组合；和任选地，水。
Description
本发明涉及包含一种变性剂的乙醇和包含所述变性乙醇的产品。
背景技术
乙醇或酒精在多种无意用于消费的产品中的任何一种中作为成分使用。在有些产品中，乙醇是一种溶剂，多种不同组成组分溶解于其中。例如，乙醇因其溶解性而经常用于制备化妆品，或因其抗菌性而用于配制消毒组合物。由于这类产品并非意图用于摄入，因此通常将用于这类产品中的乙醇变性以使其不能饮用。此外，此外政府管理机构经常对纯乙醇(如：190或200proof)的商业运输征税，即使这些乙醇目的是用于工业用途，例如用作上述的化妆品或抗菌产品中的成分。
可获得许多材料用于使乙醇变性，包括甲醇、异丙醇、碘酒、甲醛溶液、苯乙醇、氯仿和邻苯二甲酸二乙酯。已知的变性剂具有几个缺点，可能会降低与它们相关的产品的质量。例如，已知邻苯二甲酸二乙酯当用于气雾剂中时会引起打喷嚏。其它变性剂，如异丙醇和甲基异丁基酮，会影响加香产品的气味特性并且已知其中一些是颜色不稳定的。有些变性剂(如：甲醇、碘酒、甲醛、氯仿)对操作具有潜在的危害性并且如果摄入的话则可能会有毒性。
发明内容
本发明提供了一种变性乙醇形式的组合物。在第一方面，所述组合物基本由下列组分组成：
乙醇；
变性剂，所述变性剂选自由下列物质组成的组：氯己定及其盐、双胍和两种或更多种上述物质的组合；和
任选地，水。
在另一方面，本发明提供了一种组合物，所述组合物基本上由下列组分组成：
乙醇；
氯己定葡糖酸盐；和
任选地，水。
本领域的技术人员在审阅公开说明书的剩余部分，包括多个实施例的详细描述和附带的权利要求书之后将进一步理解本发明的多个方面。
具体实施方式
本发明提供适合用作乙醇变性剂的材料。本文所述的材料在可用作变性剂时不具有已知的和使用过的变性剂的危险特性。此外，可以将本发明的变性乙醇掺入到其它组合物中，其中所述变性乙醇将提供附加的抗菌或防腐特性。
适用于本发明的变性剂包括氯己定及其盐。适合的氯己定盐包括但不限于氯己定葡糖酸盐、氯己定乳酸盐、氯己定醋酸盐、氯己定异丁酸盐、氯己定葡庚糖酸盐、氯己定甲磺酸盐和氯己定盐酸盐。其它适合的变性剂包括双胍类如盐酸二甲双胍，以及阿来西定盐(1，1′-环己烷-双[5-(2-乙基己基)双胍])如阿来西定二盐酸盐、阿来西定二氢氟酸盐和阿来西定二醋酸盐。还可以想到两种或更多种上述变性剂的组合。
在本发明的实施例中，氯己定葡糖酸盐(“CHG”)用作变性剂而不会增加乙醇对工作场所的人或潜在的滥用者的安全危害。CHG常用作防腐剂。虽然CHG已用于供外科手术擦洗、处理皮肤伤口的清洁剂中，以及用作杀菌性的洗手液和抗菌性的牙科漱口液，但其作为乙醇变性剂以前还未被认识到。CHG非常适合作为变性剂，因为它在醇溶液中具有高溶解性、低毒性并具有能与口腔中的粘膜组织结合以提供一种持久令人不适的苦味的能力。
在上述实施例中，CHG与其它氯己定盐一样可以用作变性剂，同时还提供可作为抗菌剂和防腐剂的附加优点。因此，所述氯己定盐首先用以提供作为变性剂的效用，其后可在掺入了所述变性乙醇作为一种组分的组合物中用作抗菌剂。换句话讲，可以将包含(例如)乙醇和CHG作为单独组分的组合物与变性乙醇一起配制，作为乙醇和CHG组分的来源。
在本发明的实施例中，双胍类化合物用于使乙醇变性。双胍类还显示具有杀菌和抗菌活性。如果具有某些类型的取代基，所述化合物还可用作毛发护理产品和其它个人卫生用品的组分。
除了提供一点苦味和令人不适的味道外，本文描述的变性剂还可以在重复接触之后污染牙齿或变色，并且简单的刷洗牙齿对除去色斑通常无效。该附加效果为不滥用用这些试剂变性的乙醇产品提供了另外的动力，并且其潜在地作为那些滥用所述变性乙醇人群的一种指示。
根据本发明的组合物可以通过混合各个组分而制备。用于本发明中的变性剂可以加入190至200proof乙醇以使最终变性剂的浓度为至少约0.01重量％。在一些实施例中，所述变性剂的浓度按总重量计可以在约0.01％至约20％的范围内。在其它实施例中，最终变性剂的浓度按总重量计可以降至约0.08％至约1.5％的范围内。根据本发明的乙醇/变性剂溶液的适合度(或不适合度)的检测可以按照(例如)27CFR 17.134中提出的方法，27CFR 17.134部分地提出，产品用于饮用目的不适合度可以通过感官检验来确定。在这种检验中，可以用水将所述产品稀释至乙醇浓度为15％并品尝。也可以采用用于产品饮用适合度检测的其它方法。
本发明的变性乙醇还可以用于制备需要乙醇及所述变性剂作为其组分的其它产品。这些产品可以包含1重量％至99重量％的变性乙醇。例如，在一些实施例中，所述变性乙醇可以是一种需要乙醇和变性剂的消毒液中的一种组分，尽管在这种消毒液中需要所述变性剂可能是因其具有抗菌性质。在一些实施例中，所述变性乙醇可以是一种需要乙醇和变性剂的美容产品中的一种组分，尽管所述变性剂在化妆品中有用的是其抗菌性质。在配制这些其它产品过程中，可以简单地将所述变性乙醇加入到产品制剂的其它组分中，以提供特殊产品所需浓度的乙醇和变性剂。本领域的技术人员将会知道，乙醇组合物中所述变性剂的浓度可以用额外的变性剂补充，以使所述变性剂的浓度达到(例如)抗菌功效所需的水平。
实例
本发明实施例的另外特征在以下的非限制性实例中进一步描述。除非另外说明，所有份数和百分比均以重量计。
在多个实例中描述的用于制剂的组分列于表1中。
表1
组分
| 组分 | 供应商/卖家 | 供应地 |
| 20％B.P.1氯己定葡糖酸盐(CHG)溶液 | Xttrium Laboratories | Chicago，IL |
| 190proof USP乙醇(92.4w/w％乙醇和7.6w/w％水) | Aaper Alcohol | Shelbyville，KY |
| 甘油 | Dow Chemical | Midland，MI |
| PEG 600 | Dow Chemical | Midland，MI |
| PEG 900 | Dow Chemical | Midland，MI |
1.British Pharmacopoeia
实例1-3，比较例A、B和C
实例1-4和比较例A和B的乙醇溶液制备如下：将列于表1中的组分按照列于表2中的量加入到一个干净的玻璃容器中。摇动混合溶液。每种乙醇溶液的饮用不适合度检测通过如27CFR 17.134中描述的感官检验进行：用水将产品稀释至乙醇浓度按体积计为15％，品尝样品。两个人，一名男性，一名女性，品尝0.5克的每种所述乙醇溶液以证明指定变性剂的效力。
多种乙醇溶液的组合物和味觉观察在表2中列出。
表2
实例1-3和比较例A、B和C
| 实例 | 组分 | 稀释后变性剂的最终量％w/w | 味觉观察 |
| 比较例A | 39.40克190proof USP乙醇+260.60克纯化水 | 无 | 乙醇味 |
| 实例1 | 14.92克比较例A+0.079克20％CHG | 0.1％CHG | 腐味、苦味、恶劣的味道。品尝持续几个小时。 |
| 实例2 | 7.50克比较例A+7.50克实例1 | 0.05％CHG | 强烈苦味、恶劣的味道。持续味道，感觉象味道涂覆在舌头上。 |
| 实例3 | 13.50克对比例A+1.50克实例2 | 0.01％CHG | 弱苦味，随着时间过去产生令人不适的感觉 |
| 比较例B | 13.50克比较例A+1.50克实例3 | 0.001％CHG | 乙醇味 |
| 比较例C | 14.95克比较例A+0.01克PEG 600+0.01克PEG 900 | 0.34％甘油(组合) | 乙醇味 |
实例4-6
表3中列出的实例表示了用于使100加仑(378.5升)190proof的乙醇(“EtOH”)变性而具有不同水平的CHG的方法的量和浓度。例如，实例6通过将1.23kg 20％w/v CHG加入到100加仑(378.5升)190proof乙醇中来制备。这样形成具有285kg纯乙醇、24.3kg水和0.08％w/w浓度的CHG的变性乙醇的溶液。如果将实例4-6的一乙醇溶液稀释降至27CFR 17.134中(“饮用不适合度检测”)允许的15％v/v乙醇，得到的稀释溶液中CHG浓度将分别为0.10％w/w、0.05％w/w和0.01w/w。
表3
变性乙醇制剂实例
| 实例序号 | 190ProofEtOH(升) | 加入20％w/vCHG的量(kg) | EtOH重量(kg) | 水的重量(克) | 最终的EtOH％w/w | 最终的CHG％w/w | 最终的水％w/w | 如果稀释至15％v/vEtOHCHG％ |
| 4 | 378.5 | 12.3 | 285 | 33.3 | 88.88 | 0.72 | 10.40 | 0.10 |
| 5 | 378.5 | 6.17 | 285 | 28.3 | 90.63 | 0.37 | 9.00 | 0.05 |
| 6 | 378.5 | 1.23 | 285 | 24.3 | 92.07 | 0.08 | 7.85 | 0.01 |
已经参考其实施例而描述了本发明。对于本领域的技术人员显而易见的是，可以对已描述的实施例进行变化、修改或添加而不脱离本发明的范围。
Claims (11)
1.一种组合物，其基本上由下列组分组成：
乙醇；
变性剂，所述变性剂选自由下列物质组成的组：氯己定及其盐、双胍、以及两种或更多种上述物质的组合；和
可选地，水。
2.根据权利要求1所述的组合物，其中所述氯己定盐选自由下列物质组成的组：氯己定葡糖酸盐、氯己定乳酸盐、氯己定醋酸盐、氯己定异丁酸盐、氯己定葡庚糖酸盐、氯己定甲磺酸盐、氯己定盐酸盐、以及两种或更多种上述物质的组合。
3.根据权利要求1所述的组合物，其中所述双胍类选自由下列物质组的组：盐酸二甲双胍、阿来西定盐、以及两种或更多种上述物质的组合。
4.根据权利要求3所述的组合物，其中所述阿来西定盐选自由下列物质组成的组：阿来西定二盐酸盐、阿来西定二氢氟酸盐、阿来西定二醋酸盐、以及两种或更多种上述物质的组合。
5.根据权利要求1所述的组合物，其中所述组合物中存在的变性剂的浓度为至少约0.01重量％。
6.根据权利要求1所述的组合物，其中所述组合物中存在的变性剂的浓度在0.01重量％至20重量％的范围内。
7.根据权利要求1所述的组合物，其中所述组合物中存在的变性剂的浓度在0.08重量％至1.5重量％的范围内。
8.一种组合物，其基本上由下列组分组成：
乙醇；
氯己定葡糖酸盐；和
可选地，水。
9.根据权利要求8所述的组合物，其中所述组合物中存在的氯己定葡糖酸盐的浓度为至少约0.01重量％。
10.根据权利要求8所述的组合物，其中在所述组合物中存在的氯己定葡糖酸盐的浓度在0.01重量％至20重量％的范围内。
11.根据权利要求8所述的组合物，其中在所述组合物中存在的氯己定葡糖酸盐的浓度在0.08重量％至1.5重量％的范围内。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/314,761 US20070138439A1 (en) | 2005-12-21 | 2005-12-21 | Denaturant for ethanol |
| US11/314,761 | 2005-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101340890A true CN101340890A (zh) | 2009-01-07 |
Family
ID=38172410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800477921A Pending CN101340890A (zh) | 2005-12-21 | 2006-12-06 | 乙醇变性剂 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070138439A1 (zh) |
| EP (1) | EP1971314A1 (zh) |
| CN (1) | CN101340890A (zh) |
| AU (1) | AU2006329961A1 (zh) |
| TW (1) | TW200731995A (zh) |
| WO (1) | WO2007075281A1 (zh) |
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|---|---|---|---|---|
| CA2802091A1 (en) | 2010-06-09 | 2011-12-15 | Mannington Mills, Inc. | Floor covering composition containing renewable polymer |
| EP2944565B1 (en) | 2014-05-13 | 2017-09-27 | Entrotech, Inc. | Erosion protective sleeve |
| CA3078628A1 (en) | 2017-10-12 | 2019-04-18 | Medline Industries, Inc. | Antiseptic wipes |
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|---|---|---|---|---|
| US3887712A (en) * | 1973-06-15 | 1975-06-03 | Merck & Co Inc | Oral hygiene products |
| US4080441A (en) * | 1976-12-27 | 1978-03-21 | Colgate-Palmolive Company | Antibacterial oral composition |
| US4476107A (en) * | 1983-06-13 | 1984-10-09 | Basf Wyandotte Corporation | Mouthwash composition |
| FI841252A (fi) * | 1984-03-29 | 1985-09-30 | Orion Yhtymae Oy | Ny munvattenkomposition och foerfarande foer dess framstaellning. |
| US4661504A (en) * | 1984-11-02 | 1987-04-28 | Atomergic Chemetals Corporation | Denatonium saccharide compositions and method of use |
| US4652577A (en) * | 1984-11-02 | 1987-03-24 | Atomergic Chemetals Corporation | Denatonium saccharide, compositions and method of use |
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US4870108A (en) * | 1988-09-20 | 1989-09-26 | Page Leslie A | Liquid antiseptic composition |
| JPH02140167A (ja) * | 1988-11-22 | 1990-05-29 | Saraya Kk | 手指消毒用組成物 |
| US5270351A (en) * | 1992-06-15 | 1993-12-14 | American Dental Association Health Foundation | Adhesion-promoting agents incorporating polyvalent cations |
| EP0833606B1 (en) * | 1995-06-22 | 2003-10-01 | Minnesota Mining And Manufacturing Company | Stable hydroalcoholic compositions |
| US6503952B2 (en) * | 1995-11-13 | 2003-01-07 | The Trustees Of Columbia University In The City Of New York | Triple antimicrobial composition |
| ES2196414T3 (es) * | 1997-02-24 | 2003-12-16 | Kuraray Co | Composicion antimicrobiana para la deteccion de caries. |
| DE19714580A1 (de) * | 1997-04-09 | 1998-10-15 | Haarmann & Reimer Gmbh | Vergällungsmittel für Ethanol |
| GB9726132D0 (en) * | 1997-12-10 | 1998-02-11 | Unilever Plc | Deodorant composition |
| US7141250B2 (en) * | 2001-08-06 | 2006-11-28 | Euro-Celtique S.A. | Pharmaceutical formulation containing bittering agent |
| US7144587B2 (en) * | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
| US7338927B2 (en) * | 2002-08-20 | 2008-03-04 | Alda Pharmaceuticals Corp. | Wide spectrum disinfectant comprising an alcohol and disinfectant mixture |
| US20070292355A1 (en) * | 2002-10-25 | 2007-12-20 | Foamix Ltd. | Anti-infection augmentation foamable compositions and kit and uses thereof |
| DE10311171A1 (de) * | 2003-03-12 | 2004-09-23 | Henkel Kgaa | Mund- und Zahnpflegemittel |
| US20040185068A1 (en) * | 2003-03-18 | 2004-09-23 | Zhi-Jian Yu | Self-emulsifying compositions, methods of use and preparation |
| US8906413B2 (en) * | 2003-05-12 | 2014-12-09 | Supernus Pharmaceuticals, Inc. | Drug formulations having reduced abuse potential |
| US7670997B2 (en) * | 2006-06-08 | 2010-03-02 | Bausch & Lomb Incorporated | Ophthalmic compositions comprising a branched, glycerol monoalkyl compound and a fatty acid monoester |
-
2005
- 2005-12-21 US US11/314,761 patent/US20070138439A1/en not_active Abandoned
-
2006
- 2006-12-06 AU AU2006329961A patent/AU2006329961A1/en not_active Abandoned
- 2006-12-06 EP EP06839099A patent/EP1971314A1/en not_active Withdrawn
- 2006-12-06 CN CNA2006800477921A patent/CN101340890A/zh active Pending
- 2006-12-06 WO PCT/US2006/046561 patent/WO2007075281A1/en active Application Filing
- 2006-12-20 TW TW095147981A patent/TW200731995A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1971314A1 (en) | 2008-09-24 |
| TW200731995A (en) | 2007-09-01 |
| AU2006329961A1 (en) | 2007-07-05 |
| US20070138439A1 (en) | 2007-06-21 |
| WO2007075281A1 (en) | 2007-07-05 |
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