CN101198308A - 可起泡的醇组合物、体系和使用方法 - Google Patents
可起泡的醇组合物、体系和使用方法 Download PDFInfo
- Publication number
- CN101198308A CN101198308A CNA2006800212051A CN200680021205A CN101198308A CN 101198308 A CN101198308 A CN 101198308A CN A2006800212051 A CNA2006800212051 A CN A2006800212051A CN 200680021205 A CN200680021205 A CN 200680021205A CN 101198308 A CN101198308 A CN 101198308A
- Authority
- CN
- China
- Prior art keywords
- dimethicone copolyol
- compositions
- dimethyl siloxane
- copolyol
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 82
- 238000000034 method Methods 0.000 title abstract description 8
- 239000006260 foam Substances 0.000 claims abstract description 140
- 229940008099 dimethicone Drugs 0.000 claims abstract description 103
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 103
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract description 103
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 103
- 239000004094 surface-active agent Substances 0.000 claims abstract description 60
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 25
- -1 dimethyl siloxane Chemical class 0.000 claims description 127
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 44
- 239000003974 emollient agent Substances 0.000 claims description 38
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- 239000002202 Polyethylene glycol Substances 0.000 claims description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
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- 239000011734 sodium Substances 0.000 claims description 13
- 229910052708 sodium Inorganic materials 0.000 claims description 13
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 12
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- 239000002253 acid Substances 0.000 claims description 11
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 11
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- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 8
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 claims description 6
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- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 6
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- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 5
- 239000004215 Carbon black (E152) Substances 0.000 claims description 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 5
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 5
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 4
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- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- 150000001298 alcohols Chemical class 0.000 claims description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
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- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 4
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- 229920002401 polyacrylamide Polymers 0.000 claims description 4
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 3
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims description 3
- ZDSCFBCGDDCJFZ-UHFFFAOYSA-N 2-(methylamino)ethanesulfonic acid;sodium Chemical compound [Na].CNCCS(O)(=O)=O ZDSCFBCGDDCJFZ-UHFFFAOYSA-N 0.000 claims description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 3
- 229920002413 Polyhexanide Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- AMZWNNKNOQSBOP-UHFFFAOYSA-M [n'-(2,5-dioxoimidazolidin-4-yl)carbamimidoyl]oxyaluminum;dihydrate Chemical compound O.O.NC(=O)NC1N=C(O[Al])NC1=O AMZWNNKNOQSBOP-UHFFFAOYSA-M 0.000 claims description 3
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
- HDYRYUINDGQKMC-UHFFFAOYSA-M acetyloxyaluminum;dihydrate Chemical compound O.O.CC(=O)O[Al] HDYRYUINDGQKMC-UHFFFAOYSA-M 0.000 claims description 3
- 229940015825 aldioxa Drugs 0.000 claims description 3
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- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 3
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- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 3
- 239000004327 boric acid Substances 0.000 claims description 3
- 239000007766 cera flava Substances 0.000 claims description 3
- 229940110456 cocoa butter Drugs 0.000 claims description 3
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- 229920006037 cross link polymer Polymers 0.000 claims description 3
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- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- FBUKVWPVBMHYJY-UHFFFAOYSA-M nonanoate Chemical compound CCCCCCCCC([O-])=O FBUKVWPVBMHYJY-UHFFFAOYSA-M 0.000 claims description 3
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- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
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- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 claims description 2
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- 150000003739 xylenols Chemical class 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229940118257 zinc undecylenate Drugs 0.000 description 1
Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/896—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate
- A61K8/898—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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Abstract
本发明描述了一种组合物、用于分配该组合物的体系和使用该组合物的方法。所述组合物包括:(A)其量足以提供抗微生物活性的一元醇;(B)包括二甲基硅氧烷表面活性剂的表面活性剂;和(C)助洗剂,所述助洗剂的量足够为由组合物形成的泡沫提供稳定性或改进稳定性。
Description
本发明涉及可起泡的醇组合物、用于分配所述组合物的体系和使用所述组合物的方法。
背景技术
可起泡的皂产品包含大量空气。尽管与不可起泡的组合物相比,可以经济地制造这些组合物,但包括高醇含量的可起泡组合物的配方通常需要作为气溶胶产品提供的组合物,所述气溶胶产品包括推进剂(例如烃、碳氟化合物、压缩气体)以在从气溶胶容器中分配组合物时促进起泡。例如,这些气溶胶组合物还可能包括聚合胶凝剂、适度高分子量(例如C16至C22)的醇和非离子型表面活性剂。制造气溶胶产品是昂贵的,因为需要加压容器和起泡推进剂的加入。
在具有高醇含量的非气溶胶皂产品的配方中,已经将表面活性剂包括到这类组合物中,以在通过机械泵等分配组合物时促进一定水平的起泡。表面活性剂可以促进至少一些程度的初始起泡,但这类非气溶胶泡沫通常是不稳定的,只要它们一被分配就趋于塌陷。尽管已知一些氟化物表面活性剂可在非气溶胶组合物中促进更稳定的泡沫,但氟化物表面活性剂可能引起环境关注。
需要提供可起泡的含醇组合物,所述组合物被配制成抗微生物的,并可应用于皮肤(例如手)。需要含醇组合物,所述组合物将在缺少气溶胶推进剂时形成稳定的泡沫,并将把醇递送到皮肤上用于快速皮肤消毒。在前述需要中,希望提供包含可起泡的低粘度含醇组合物,所述组合物是安全和有效的,同时提供消费者可能期望的性质。
发明概述
在一个方面,本发明提供了组合物,其包括:
(A)其量足以提供抗微生物活性的一元醇;
(B)包括二甲基硅氧烷表面活性剂的表面活性剂;和
(C)助洗剂(builder),所述助洗剂的量足够为由所述组合物形成的泡沫提供稳定性或改进其稳定性。
在另一个方面,本发明提供了包括容器和上述组合物的体系,在压力下将组合物包含到容器内,推进剂存在于组合物内。
在还一方面,本发明提供了一种体系,该体系包括:含有贮库和手动泵的分配器;和包含在该贮库内的上述组合物。
在还一方面,本发明提供了包括上述组合物的皮肤消毒剂。
在还一方面,本发明提供了包括上述组合物的术前擦手物。
在还一方面,本发明提供了用于消毒表面的方法,所述方法包括:将一定体积的上述组合物应用到表面上,所述组合物为稳定泡沫的形式。
将理解,本文所用的术语将被理解为根据本发明所处时代的本领域技术人员的理解定义。然而,本文所用的某些术语应该被理解为具有本文明示的含义:
“助洗剂”指这样的物质,该物质能够被掺入作为本发明组合物的组分,以在从气溶胶或非气溶胶分配器中分配组合物时帮助产生稳定的泡沫。与缺少助洗剂的相同体积的组合物相比,包括助洗剂的组合物可以产生更低的泡沫密度(更大的体积)。
在用于本文时,“润肤剂”广泛地指能够保持或改进皮肤的水分水平、顺从性或外观的物质。
“泡沫”指在液体(例如本发明的组合物)上或由液体形成的空的气泡团。
“HLB”指“亲水亲油平衡值”,或表面活性分子或表面活性剂内油溶性部分与水溶性部分之间的平衡。
在用于本文时,“聚合物”指具有重复单元并且数均分子量为至少20,000的天然或合成分子。
在用于本文时,“聚(环氧丙烷)”和“聚(环氧乙烷)”意欲分别与“聚丙二醇”或“PPG”和“聚乙二醇”或“PEG”同义。聚(环氧丙烷)和聚(环氧乙烷)在本文中也分别简写为“PPO”和“PEO”。
在用于本文时,“溶剂”、“溶剂体系”或“水醇溶剂”指本发明中醇与水的组合。
在用于表示起泡组合物时,“稳定的”指在产生泡沫后(例如,通过在环境温度下摇动组合物或通过从气溶胶或非气溶胶分配器中分配组合物),泡沫可在至少约5秒的一段时间内保持可测量的高度。具体泡沫的稳定性还可以用测量时段后的泡沫高度表示(例如1分钟后6mm)。在实施例中进一步讨论了泡沫高度测量。
通过考虑本发明的剩余部分,包括详述、实施例和所附权利要求书,本领域技术人员将更充分地理解本发明的各种特征和方面。
发明详述
本发明提供了由醇、表面活性剂和助洗剂组成的可起泡组合物。本发明的组合物可以是水性组合物。可以包括任选的成分如抗微生物剂和/或润肤剂,以提供或增强组合物的性质。通过提供其剪切稀化粘度优于胶凝组合物并且能够更容易地揉搓到敏感组织上的组合物,本发明的组合物提供了用泡沫给皮肤消毒的益处。此外,在应用到表面如手上后,本发明的组合物通常将比凝胶干燥得更快。
醇
本发明的组合物将包括至少一种醇,该醇提供快速杀灭广谱微生物的能力。本发明的组合物适合用于皮肤或其它表面上,并可以用作例如手消毒剂。在本发明的实施方案中,所述一种或多种醇是一元醇。通常,本发明的组合物包括具有低级烃链长度的醇如C2至C4醇。在一些实施方案中,本发明的组合物包括单一的醇。在其它实施方案中,可以存在两种或多种醇的共混物。在一些实施方案中,所述醇将由乙醇组成。在还有的其它实施方案中,所述醇将由丙醇(例如正丙醇和/或异丙醇)组成。在还有的其它实施方案中,所述醇将由丁醇(例如正丁醇、仲丁醇和叔丁醇)组成。在一些实施方案中,所述醇溶于水中以提供醇-水溶剂。
本发明的实施方案可以包括醇含量为约35wt%至约99.5wt%的组合物。在一些实施方案中,本发明的组合物将具有约60%至约80%的醇含量。具有前述范围内的醇含量的组合物通常可提供有效的细菌杀灭。
表面活性剂
本发明的组合物包含至少一种表面活性剂。在一些实施方案中,按组合物的总重量计,表面活性剂可以以约0.1wt%至约10wt%的浓度存在于本发明的组合物中。在一些实施方案中,按组合物的总重量计,表面活性剂可以以约0.5wt%至约5wt%的浓度存在于本发明的组合物中。本领域技术人员将理解,当某些表面活性剂浓度大于5wt%时,它们可能赋予组合物粘性或甚至油性的感觉。尽管预期所述表面活性剂的浓度处于本发明的范围内,但在配制组合物供消费者使用时,本领域技术人员仍可能希望考虑表面活性剂浓度的化妆效果。在一些实施方案中,用非氟化表面活性剂配制本发明的组合物,而无需使用氟化物推进剂。
用于本发明的具体表面活性剂包括二甲基硅氧烷表面活性剂。二甲基硅氧烷表面活性剂的例子包括聚二甲基硅氧烷共聚醇— —具有聚氧乙烯(PEO)和/或聚氧丙烯(PPO)侧链的二甲基硅氧烷的聚合物。在一些实施方案中,这些表面活性剂可以是羟基、甲氧基或丁氧基封端的,PEO与PPO的摩尔比(PEO/PPO)范围可以为0/50至50/0,二甲基硅氧烷部分的分子量范围可以为200至20,000。用于本发明的表面活性剂可以包括具体的二甲基硅氧烷表面活性剂。适用于本发明实施方案的具体表面活性剂包括但不限于:甲氧基封端的聚乙二醇二甲基硅氧烷,平均分子量为约3000;具有35/65(w/w)聚乙二醇/聚丙二醇共聚物的侧醚的二甲基硅氧烷,合并的平均分子量为约7,000;具有18/18(摩尔比)聚乙二醇/聚丙二醇的聚二甲基硅氧烷共聚醇;具有17/18(摩尔比)聚乙二醇/聚丙二醇的聚二甲基硅氧烷共聚醇;具有甲氧基封端的聚乙二醇/聚丙二醇的聚二甲基硅氧烷共聚醇,平均分子量为约20,000,HLB为9-12;具有甲氧基封端的聚乙二醇的聚二甲基硅氧烷共聚醇,合并的平均分子量为约3000;具有甲氧基封端的聚乙二醇的聚二甲基硅氧烷共聚醇,合并的平均分子量为约6000;具有羟基封端的聚乙二醇的聚二甲基硅氧烷共聚醇,合并的平均分子量为约5000,HLB为13-17;二甲基硅氧烷共聚醇乳酸酯;硅氧烷共聚醇壬酸酯;羟基封闭的聚二甲基硅氧烷共聚醇;羟基封端的聚乙二醇-12二甲基硅氧烷;二甲基硅氧烷共聚醇月桂酸酯;硅氧烷季铵盐(Quaternary)1;羟基封端的聚乙二醇二甲基硅氧烷,平均分子量为约4000;甲氧基封端的聚乙二醇二甲基硅氧烷,平均分子量为约600;硅氧烷季铵盐2(肉豆蔻基);二甲基硅氧烷共聚醇乙酰基甲基牛磺酸钠;丁氧基封端的聚(环氧丙烷)二甲基硅氧烷,平均分子量为约3,000;和二甲基硅氧烷共聚醇异硬脂酸酯。
此外,下列表面活性剂可以用于本发明:二甲基硅氧烷双氨基羟基丙基共聚醇、二甲基硅氧烷共聚醇乙酸酯、二甲基硅氧烷共聚醇己二酸酯、二甲基硅氧烷共聚醇杏仁油酸酯(almondate)、二甲基硅氧烷共聚醇胺、二甲基硅氧烷共聚醇鳄梨油酸酯(avocadoate)、二甲基硅氧烷共聚醇蜂蜡、二甲基硅氧烷共聚醇山嵛酸酯、二甲基硅氧烷共聚醇苯甲酸酯、二甲基硅氧烷共聚醇双羟基乙胺、二甲基硅氧烷共聚醇borageate、二甲基硅氧烷共聚醇丁基醚、二甲基硅氧烷共聚醇可可脂酸酯(cocoa butterate)、二甲基硅氧烷共聚醇交联聚合物(crosspolymer)、二甲基硅氧烷共聚醇dhupa butterate、二甲基硅氧烷共聚醇乙基醚、二甲基硅氧烷共聚醇羟基硬脂酸酯、二甲基硅氧烷共聚醇异硬脂酸酯、二甲基硅氧烷共聚醇kokum butterate、二甲基硅氧烷共聚醇乳酸酯、二甲基硅氧烷共聚醇月桂酸酯、二甲基硅氧烷共聚醇芒果脂酸酯(mangobutterate)、二甲基硅氧烷共聚醇meadowfoamate、二甲基硅氧烷共聚醇甲基醚、二甲基硅氧烷共聚醇mohwa butterate、二甲基硅氧烷共聚醇辛基十二烷基柠檬酸酯、二甲基硅氧烷共聚醇橄榄油酸酯、二甲基硅氧烷共聚醇磷酸酯、二甲基硅氧烷共聚醇邻苯二甲酸酯、二甲基硅氧烷共聚醇sal butterate、二甲基硅氧烷共聚醇shea butterate、二甲基硅氧烷共聚醇硬脂酸酯、二甲基硅氧烷共聚醇十一烯酸酯、二甲基硅氧烷羟基丙基三甲基氯化铵(trimonium chloride)、二甲基硅氧烷丙基pg-甜菜碱、聚硅氧烷-10、聚硅氧烷-8、二甲基硅氧烷丙基乙二胺山嵛酸酯、氨基双丙基二甲基硅氧烷氨基乙基氨基丙基二甲基硅氧烷、山嵛基三甲基铵(trimonium)二甲基硅氧烷共聚醇邻苯二甲酸酯、双-氨基丙基共聚醇氨基丙基二甲基硅氧烷、双-羟基乙氧基丙基二甲基硅氧烷、十六烷基三乙基铵(triethylmonium)二甲基硅氧烷共聚醇琥珀酸酯、二甲基硅氧烷共聚醇硫酸酯、二甲基硅氧烷共聚醇磷酸酯、二甲基硅氧烷聚甘油、共聚醇二甲基硅氧烷磺基琥珀酸二钠、共聚醇聚二甲基甲硅氧烷基乙基二甲基硅氧烷、共聚醇pg-可可-葡糖苷二甲基硅氧烷、共聚醇九氟己基二甲基硅氧烷共聚物、共聚醇甲基醚月桂氧基peg酰胺基丙基二甲基硅氧烷、共聚醇油基醚二甲基硅氧烷、羧基癸基共聚醇二甲基硅氧烷钠。
预期在单一组合物内组合两种或多种前述二甲基硅氧烷表面活性剂也处于本发明的范围内。
助洗剂
为了稳定在摇动组合物时、或者在从气溶胶或非气溶胶分配器中分配组合物时由它们产生的泡沫,本发明的组合物可以包括至少一种助洗剂。在一些实施方案中,包括某些助洗剂可以为本发明的组合物提供化妆贡献。合适的助洗剂可以包括下列一种或多种:聚(环氧乙烷)、羟乙基纤维素、羟丙基纤维素。在一些实施方案中,助洗剂将只包括上述助洗剂中的一种。在其它实施方案中,助洗剂将包括上述助洗剂中的两种或多种的组合。在一些实施方案中,助洗剂将包括平均分子量为约200,000至约4,000,000的聚(环氧乙烷)。适用于本发明组合物的一种聚(环氧乙烷)是已知商品名为POLYOXTM,购自Dow ChemicalCanada Inc.,Sarnia,Ontario的聚(环氧乙烷)。合适的POLYOX组合物包括平均分子量为1,000,000的“WSR N12K”;平均分子量为4,000,000的“WSR-301”;平均分子量为2,000,000的“WSR N60K”;和平均分子量为200,000的“WSR N-80”。
当助洗剂包括在本发明的组合物中时,该助洗剂的浓度可以小于或等于约0.1%。在一些实施方案中,组合物中助洗剂的浓度为约0.06%。
通常,助洗剂可增强在摇动本发明的组合物时或在分配组合物时产生的泡沫的稳定性。适用于本发明的助洗剂将包括提供或增强泡沫稳定性的那些,即在泡沫产生后至少约5秒内提供可测量泡沫高度的那些。在一些实施方案中,助洗剂可溶于本发明组合物所用的醇中。在一些实施方案中,助洗剂将可在醇内膨胀。在还有的其它实施方案中,助洗剂的特征在于可分散在醇中。
在一些实施方案中,合适的泡沫助洗剂包括含有高分子量聚合物的化合物。在一些实施方案中,这些聚合物可溶于醇或可溶于水醇。可用于本发明的具体聚合物包括但不限于:聚(环氧乙烷)(分子量为100,000至10,000,000)、高分子量聚乙烯-聚丙烯共聚物、羟乙基纤维素、羟丙基纤维素。当存在聚合物时,其浓度将为约0.001至约5%。在一些实施方案中,聚合物浓度将为约0.01%至约0.5%。
下列类型内的聚合物可用作本发明组合物内的助洗剂:羟丙基瓜尔胶、聚季铵盐(polyquaterium)-4、聚季铵盐-10、十六烷基羟乙基纤维素、乙基羟基乙基纤维素、聚甘油、高分子量polyoxamer、高分子量polyoxamine、聚丙烯酰胺、具有烷基醇或酸官能烷基的高分子量聚乙二醇酯和醚、聚丙烯酰胺基甲基丙烷磺酸、聚丙烯酸、聚乙烯/马来酸异丙酯/马来酸共聚醇、聚甲基丙烯酰胺基丙基三甲基氯化铵、聚甲基丙烯酰胺基丙基三甲基甲硫酸(methosulfate)铵、聚甲基丙烯酸、聚季铵盐-1至聚季铵盐-47、聚乙烯基甲基醚、丁基化的聚乙烯基吡咯烷酮、羟丙基甲基纤维素;羟丙基纤维素;包含n-乙烯基内酰胺单体单元的交联和未交联的均聚物或交联和未交联的共聚物。
N-乙烯基内酰胺单体的非限制性例子为:N-乙烯基-2-吡咯烷酮;N-乙烯基-2-戊内酰胺;N-乙烯基-2-己内酰胺;以及任何上述物质的混合物。通常,聚(N-乙烯基内酰胺)是N-乙烯基-2-吡咯烷酮的均聚物。可用于前述N-乙烯基内酰胺单体的共聚单体的非限制性例子包括:N,N-二甲基丙烯酰胺、丙烯酸、甲基丙烯酸、羟乙基甲基丙烯酸酯、丙烯酰胺、2-丙烯酰胺基-2-甲基-1-丙烷磺酸及其盐、和乙酸乙烯酯。
尽管可以将上述助洗剂单独添加到本发明的组合物中,但也预期两种或多种所述助洗剂的组合处于本发明及其衍生物的范围内。
组合物的粘度
本发明的组合物在23℃通常将具有极低的粘度。在一些实施方案中,本发明的组合物可根据组合物的状态而具有不同的粘度。例如,处于预分配条件下的组合物,即它在被分配前在分配器中处于“预发泡”状态,其在23℃的粘度可为约0.5至约100cps。在一些实施方案中,本发明组合物的预发泡粘度将为约0.5cps至约50cps。在还有的其它实施方案中,本发明组合物的预发泡粘度将为约0.5cps至约20cps。当从非气溶胶泵型分配器中分配本发明的组合物时,组合物将起泡,泡沫通常将具有比分配前液体“未起泡”组合物的粘度更高的粘度。还将理解,添加润肤剂和/或其它任选成分(本文所述)也可能对粘度有影响(正面地或负面地)。
泡沫密度
本发明的组合物将在从分配器中摇动分配时起泡。将理解,组合物的泡沫密度可根据任何各种因素而变化。例如,上述未起泡组合物的粘度可影响泡沫密度。而且,用于递送起泡组合物的分配器或非气溶胶泵的设计也可以影响组合物的泡沫密度至如下程度,即分配器和/或泵影响组合物的起泡。此外,在分配组合物时,施加给泵的力的量和运行泵的相对速度也可影响组合物的起泡及其所得粘度。
任选成分
除了醇-水、表面活性剂和助洗剂外,本发明的组合物还可以任选地包括其它成分如盐、润肤剂、稳定剂、抗微生物剂、香料、治疗药、推进剂和额外的乳化剂。下面讨论每种这些任选成分及其各自对最终组合物的性质的影响。
可以将润肤剂任选地添加到本发明的组合物中,从而当将组合物应用于例如使用者的手时,能够以可提高角质层含湿量的形式提供组合物。通常基于功能将润肤剂分成两大类。第一类润肤剂通过形成闭塞性屏障起作用,该屏障可防止水从角质层中蒸发。第二类润肤剂可渗入角质层,并物理地结合水以防止蒸发。将第一类润肤剂再分成在室温下为蜡的化合物和为液体油的化合物。第二类润肤剂包括可溶于水的那些,通常被称为保湿剂。
在用于本文时,本发明组合物所用的醇-水、表面活性剂和助洗剂组分独立于并且不同于被称为润肤剂并任选地添加到组合物中的组分。除了也可以帮助保持或改进使用者的皮肤状况的上述硅氧烷嵌段表面活性剂和助洗剂化合物外,还可以将润肤剂添加到组合物中。在一些实施方案中,所添加的润肤剂可以以约0至约30wt%的浓度被包括在本发明的组合物中。在一些实施方案中,所添加的润肤剂在组合物中的浓度可以为约0.5%至约20%。在还有的其它实施方案中,润肤剂浓度可以为约1%至约12wt%。合适的润肤剂可以选自本领域已知的任何类型。有用的润肤剂的一般性列表出现在例如美国专利4,478,853号和EPO专利申请0522624A1以及由化妆品、化妆用具、和香水协会(The Cosmetic,Toiletry,and Fragrance Association),Wash.D.C.(1992)出版的CTFA Cosmetic Ingredient Handbook(CTFA化妆成分手册),列于“Skin Conditioning agents”、“emollients”、“humectants”、“miscellaneous”和“occlusive”条目下。
在一些实施方案中,合适的润肤剂可以选自下列普通润肤剂、闭塞性润肤剂和保湿剂的非限制性列表。普通润肤剂的例子包括:长直链或支链烷基或烯基醇或酸(C8-C32)及其聚乙氧基化衍生物的短链烷基或芳基酯(C1-C6);在可用的位置上由-OH任选取代的C4-C12二酸或二醇的短链烷基或芳基酯(C1-C6);甘油、季戊四醇、乙二醇、丙二醇、以及其聚乙氧基化衍生物和聚乙二醇的烷基或芳基C1-C10酯;聚丙烯的C12-C22烷基酯或醚;聚丙二醇/聚乙二醇共聚物的C12-C22烷基酯或醚。
闭塞性润肤剂的例子包括:环状和线形二甲基硅氧烷;聚二烷基硅氧烷;聚芳基烷基硅氧烷;长直链或支链烷基或烯基醇或酸的长链(C8-C36)烷基和烯基酯;长直链或支链(C8-C36)烷基或烯基胺或酸的长链(C8-C36)烷基和烯基酰胺;烃,包括直链和支链烷烃和烯烃如角鲨烯、角鲨烷和矿物油;霍霍巴油;聚硅氧烷聚亚烷基共聚物;在可用位置上由-OH任选取代的C12-C22二酸或二醇的短链烷基或芳基酯(C1-C36)如二聚二亚油酸二异丙酯;和C12-C22烷基和烯基醇;在可用位置上由-OH任选取代的C12-C22二酸或二醇的长链烷基或芳基酯(C8-C36)如二聚二亚油酸二异硬脂酸酯;羊毛脂和羊毛脂衍生物;和蜂蜡及其衍生物。
优选保湿剂型润肤剂的非限制性例子包括:甘油、聚甘油(包括:二甘油、三甘油、聚甘油-3、四甘油、六甘油、十甘油)丙二醇、二丙二醇、聚丙二醇、聚乙二醇(PEG-2至PEG-45M,优选分子量为约300至1,000)、山梨醇、多元醇乙氧基化物(例如山梨醇聚醚-6、山梨醇聚醚-30、甘油聚醚-1至甘油聚醚-31)、聚乙二醇的甲醇盐(甲氧基PEG-2至甲氧基PEG-100)、多元醇乙氧基化物的甲醇盐(例如甘油聚醚-7甲醇盐)、羟泛酸、葡糖酸盐等。还可以使用的其它保湿剂型材料包括:1,2,6-己三醇、乙酰胺mea、氢氧化铝、精氨酸豌豆、丁氧基丙醇、丁二醇、二甲基咪唑啉酮、透明质酸二甲基硅烷醇酯、甘草酸二钾、赤藻糖醇、乙氧基-二甘醇、果糖、葡糖胺、葡糖酸、葡萄糖、葡萄糖谷氨酸盐、葡糖醛酸、谷氨酸、糖原、甘草酸、heilmoor粘土、二十六烷基二醇、组氨酸、透明质酸、氢化的蜜、氢化的淀粉、水解产物、水解的胶原、水解的弹性蛋白、水解的粘多糖、水解的角蛋白、水解的蚕丝、水解的大豆蛋白、水解的小麦蛋白、羟乙基山梨醇、肌醇、肌醇六-豌豆、乳酰胺mea、乳酸、乳糖醇、乳糖、赖氨酸豌豆、豌豆镁、麦芽糖醇、豌豆锰、甘露醇、蜂蜜(蜜提取物)、孟基豌豆、甲基葡糖聚醚-10、甲基葡糖聚醚-20、豌豆(氧脯氨酸)、乳酰胺、聚右旋糖、聚葡糖醛酸、聚甘油山梨醇、豌豆钾、PPg-20甲基葡萄糖醚、PPg-38-丁醇聚醚-37、异构糖、serica、蚕丝氨基酸、羧甲基甲壳质钠、乳酸钠、甘露糖醛酸甲基硅烷醇钠、豌豆钠、豌豆甲基硅烷醇钠、聚谷氨酸钠、可溶胶原、山梨醇、蔗糖、茶-乳酸酯、茶-豌豆、海藻糖、三内酰亚胺、尿素、木糖醇、玉米、豌豆锌及其组合。
添加一种或多种润肤剂可以影响本发明组合物的粘度和稳定性。在一些实施方案中,可以将单一的润肤剂添加到组合物中。在一些实施方案中,可以将两种或多种润肤剂添加到组合物中。尽管可以将任何各种润肤剂添加到本发明的配方中,但一些实施方案将包括单独或与水溶性润肤剂组合的蜡和油型润肤剂。在本发明的一些实施方案中,润肤剂体系可以由除闭塞性蜡和油润肤剂之外还有的保湿剂组成,所述保湿剂的浓度可获得保湿效果并可在重复使用后维持并改进皮肤的状况。润肤剂可以是不会产生痤疮的,并被选择以避免皮肤刺激或敏感反应。
除了来自本发明组合物所含的醇的抗微生物作用外,还可以添加一种或多种其它抗微生物剂(“第二抗微生物剂”),以在将组合物用作例如术前擦手物或术前患者皮肤擦洗替代物时增强组合物的抗微生物性质。换句话说,本发明的起泡组合物可以向皮肤递送第二抗微生物剂。在一些实施方案中,按组合物的总重量计,以高至10wt%的水平添加第二抗微生物剂。在一些实施方案中,可能希望将第二抗微生物剂掺入本发明的组合物中,以在醇蒸发后提供对微生物生长或再生长的持续抗微生物抵抗力。
合适的第二抗微生物剂的非限制性例子包括:对氯间二甲苯酚;三氯生;氯己定及其盐如葡萄糖酸氯己定,聚亚己基双胍及其盐如聚亚己基双胍氯化物、碘、碘递体(idodophor);脂肪酸单酯;聚-n-乙烯基吡咯烷酸-碘递体;氧化银、银及其盐、过氧化物(例如过氧化氢)、抗生素(例如新霉素、杆菌肽和多粘菌素B)。
此外,其它合适的成分也可以用于本发明的组合物中以压制微生物的再生长或可能治疗微生物的感染,例如:2,2-硫代双(4-氯苯酚);4,4-异亚丙基二酚;5-氨基-6-氯-邻甲酚;醋氨沙洛;铝克沙洛;尿囊素铝;醋酸铝;苯甲酸铝;双醋酸铝;甲酸铝;酚磺酸铝;碘化铵;酚磺酸铵;苯并异噻唑啉酮;苯并三唑;苯并酰喹;对羟基苯甲酸苄酯;盐酸小檗碱;硼酸;鲸蜡基乙基吗啉氮鎓乙基硫酸盐;鲸蜡基乙基二甲基溴化铵;西曲甲苯磺酰铵;西吡氯铵;氯胺-t;氯麝酚;氯氟苯脲;可可三甲基氯化铵;胶态硫;地衣酸铜;dedm乙内酰脲;二月桂酸dedm乙内酰脲;地喹醋酸铵;地喹氯铵;二依西双溴丙脒;二氯间二甲酚;二氯苯;二氯苯基咪唑二氧杂环戊烷;二碘甲基甲苯基砜;二甲基羟甲基吡唑;二甲氨基苯乙烯基庚基甲基碘化噻唑鎓;十二烷基苄基三甲基氯化铵;度米芬;阿魏酸;氟沙仑;乙二醛;羟甲基二氧代氮杂双环辛烷;羟丙基双三甲基二碘化铵;鱼石脂;对羟基苯甲酸异癸酯;山梨酸异丙酯;拉匹氯铵;月桂基三甲基三氯苯氧化铵;溴化十二烷基异喹啉;糖精十二烷基异喹啉;十二烷基氯吡啶鎓;间甲酚;扁桃酸;MDM乙内酰脲;MEAa-碘;茶树精油;甲苄索氯铵;混合的甲酚;壬苯醇醚-12碘;壬苯醇醚-9碘;邻甲酚;苯甲酸羟喹啉;硫酸羟喹啉;对氯苯酚;对甲酚;PEG15 dedm乙内酰脲;PEG-15 dedm乙内酰脲硬脂酸酯;PEG-5 dedm乙内酰脲;PEG-5 dedm乙内酰脲油酸酯;苯酚;对羟基苯甲酸苯氧乙酯;水杨酸苯酯;聚甲氧基双环恶唑烷;碘化钾;乳酸钾;苯氧化钾;二氯异氰尿酸钾;季铵盐(quartronium)-14;季铵盐-24;季铵盐-8;蓖麻油酰胺基丙基三甲基甲磺酸铵;碘化钠;对氯间甲酚钠;苯磺酸钠;酚磺酸钠;苯氧化钠;地衣酸钠;司吡氯铵;过氧化锶;茶-山梨酸酯;溴化四丁基铵;噻苯唑;三醋汀;十一烯酰胺dea;十一烯酰胺mea;十一烯酰胺基丙基三甲基甲磺酸铵;undecyleneth-6;十一烯酰基peg-5对羟基苯甲酸酯;地衣酸;醋酸锌;硼酸锌;苯磺酸锌;硫酸锌;十一烯酸锌;和上述物质的组合。
下列活性剂也可以用于减少微生物在皮肤上的再生长:2-溴-2-硝基丙烷-1,3-二醛;4-羟基苯甲酸;5-溴-5-硝基-1,3-二氧杂环乙烷;7-乙基双环恶唑烷;苯甲酸铵;亚硫酸氢铵;丙酸铵;亚硫酸铵;山嵛基三甲基氯化铵;苯扎溴铵;苯扎氯铵;苯扎糖精铵;苄索氯铵;苯甲酸;苯甲醇;苄基半缩甲醛;溴氯苯;苯甲酸丁酯;对羟基苯甲酸丁酯;苯甲酸钙;对羟基苯甲酸钙;丙酸钙;水杨酸钙;山梨酸钙;十一烯酸钙;西他氯铵;西替尔溴铵;西曲溴铵;西曲氯铵;氯乙酰胺;氯丁醇;氯苯;氯二甲酚;氯苯甘醚;氯咪巴唑;脱氢乙酸;二偶氮烷基脲;羟乙磺酸二溴己脒定;二氯苄醇;二甲基恶唑烷;DMDM乙内酰脲;苯甲酸乙酯;对羟基苯甲酸乙酯;甲醛;甲酸;戊二醛;己脒定;二羟乙磺酸己脒定;对羟基苯甲酸己脒定;海克替啶;氢化脂三甲基氯化铵;咪唑烷基脲;碘丙炔基氨基甲酸丁酯;苯甲酸异丁酯;对羟基苯甲酸异丁酯;苯甲酸异丁酯;异丙基甲酚;对羟基苯甲酸异丙酯;劳拉溴铵;劳拉氯铵;月桂基三甲基溴化铵;月桂基三甲基氯化铵;苯甲酸镁;丙酸镁;水杨酸镁;MEA邻苯基苯酚酯;MEA-苯甲酸酯;MEA-水杨酸酯;MEA-十一烯酸酯;乌洛托品;苯甲酸甲酯;甲基氯异噻唑啉酮;甲基二溴戊二腈;甲基异噻唑啉酮;对羟基苯甲酸甲酯;肉豆蔻基二甲基苄基氯化铵;肉豆蔻基二甲基苄基糖精铵;肉豆蔻基三甲基溴化铵;邻繖花烃(cymen)-5-01;邻苯基苯酚;油基二甲基苄基氯化铵;对氯间甲酚;苯氧基乙醇;苯氧基异丙醇;苯甲酸苯酯;醋酸苯汞;苯甲酸苯汞;硼酸苯汞;溴化苯汞;氯化苯汞;对羟基苯甲酸苯酯;吡罗克酮乙醇胺;聚氨丙基双胍;苯甲酸钾;丁基对羟基苯甲酸钾;乙基对羟基苯甲酸钾;焦亚硫酸钾;甲基对羟基苯甲酸钾;邻苯基苯酚钾;对羟基苯甲酸钾;丙酸钾;丙基对羟基苯甲酸钾;水杨酸钾;山梨酸钾;亚硫酸钾;丙酸;苯甲酸丙酯;对羟基苯甲酸丙酯;季铵盐-15;水杨酸;苯甲酸钠;亚硫酸氢钠;丁基对羟基苯甲酸钠;脱氢醋酸钠;乙基对羟基苯甲酸钠;甲酸钠;羟甲基甘氨酸钠;碘酸钠;焦亚硫酸钠;甲基对羟基苯甲酸钠;邻苯基苯酚钠;对羟基苯甲酸钠;丙酸钠;丙基对羟基苯甲酸钠;水杨酸钠;山梨酸钠;亚硫酸钠;十一烯酸钠;山梨酸;大豆三甲基氯化铵;硬脂基苄基甲基氯化铵;硬脂基三甲基氯化铵;牛脂烷基二甲基苄基氯化铵;牛脂基三甲基氯化铵;硫柳汞;三氯卡班;三氯生;十一烯酸;吡硫锌。
本发明还包括含有抗微生物剂如过氧苯甲酰的实施方案,从而该组合物可以用作例如痤疮药。在一些实施方案中,还可以用屏障化合物配制本发明的组合物以形成屏障乳膏和洗剂。可以被添加以提供屏障保护来用作皮肤屏障层以保护避免尿布疹的材料包括但不限于:0.1至60%尿囊素铝、尿囊素、醋酸铝、氢氧化铝、碱式硝酸铋、硼酸、炉甘石、纤维素(微孔)、维生素D3、可可脂、鱼肝油(合并)、胶态燕麦片、盐酸半胱氨酸、右泛醇、二甲基硅氧烷、甘油高岭土、羊毛脂(合并)、活酵母细胞衍生物、矿物油、秘鲁香脂、秘鲁香脂油、矿脂、蛋白质水解产物(1-亮氨酸、1-异亮氨酸、1-蛋氨酸、1-苯丙氨酸和1-酪氨酸)、消旋蛋氨酸、鲨鱼肝油、碳酸氢钠、硫、滑石、单宁酸、局部淀粉、维生素A、白矿脂、醋酸锌、碳酸锌和氧化锌。
在一些实施方案中,本发明的组合物可以包括如下的一种或多种配方,其含有用于治疗皮肤真菌感染如运动员脚病等的抗真菌剂。
尽管一些实施方案将包括一种额外的第二抗微生物剂,但本发明的其它实施方案可包括两种或多种额外的第二抗微生物剂。尽管可以将前述第二抗微生物剂个别或单独地添加到组合物中,但预期两种或多种前述第二微生物药的组合也处于本发明的范围内。
在一些实施方案中,可以将本发明的组合物配制成非气溶胶产品,该产品可以使用例如手动泵从贮库中分配,只要手动泵一启动就分配一定量的组合物。由泵分配的组合物的量可以是定量或不定量的,使得所分配的组合物的量可以一致或不一致。而且,本发明的组合物不限于只从一类分配器中或只通过一类手动泵分配。
在一些实施方案中,通过将推进剂添加到组合物中,能够将组合物配制成气溶胶泡沫或奶油冻。合适的推进剂可以选自氯氟碳(CFCs)、氢氯氟碳(HCFCs)、氢氟碳(HFCs)、全氟化的烷烃、和低级烷烃(C1-C5)以及一氧化二氮二甲基醚和其它溶剂可溶的推进剂。合适的低级烷烃包括例如丙烷、丁烷和异丁烷。在一些实施方案中,推进剂可以包括70/30的丙烷/异丁烷混合物。为了制备气溶胶组合物,首先将组合物配制并装填到适当的额定压力容器中。然后可以在压力下,以约2-30%、优选3-20%的体积比将合适的推进剂添加到组合物中。推进剂可以在组合物上形成独立的层,或者推进剂可以被乳化或混溶到组合物中。
本发明的组合物可以用于各种应用中,包括用作应用于表面的消毒剂。本发明的组合物适合用在哺乳动物的皮肤上,包括人的手。在一些实施方案中,组合物可以被用作术前擦手物。在本发明的非气溶胶配方中,可以将组合物包含在配有常规手动泵的非气溶胶分配器中,可以将组合物抽吸到手或身体其它区域上。分配组合物所需的抽吸行为将产生稳定泡沫形式的离散体积的被分配组合物。类似地,在包括气溶胶的实施方案中,可以以起泡组合物的离散体积从加压容器中分配气溶胶配方。在分配后,泡沫可以散布到皮肤表面上以消毒皮肤、手等。尽管一些残余物可能在醇组分蒸发后保留在皮肤上,但残余物可包括润肤剂等以提供期望的化妆效果。因此,本发明的组合物提供了以可起泡组合物的形式来给皮肤消毒的手段,在将泡沫应用到需要消毒的区域上后,无需从皮肤上漂洗所述可起泡的组合物。或者,可以用例如水洗掉留在皮肤上的不希望的残余物。
从前面可以理解,本发明还包括用于分配组合物的体系,该体系包括贮库和贮库内保留的一定量组合物,和用于从贮库中分配组合物的装置。
可以通过各种技术制备本发明的组合物,可以以任意添加顺序将一种成分添加到另一种成分中。为了保证组合物的最大稳定性,可以对组分进行有限时间段的高剪切(例如均化)。
实施例
提供下列非限制性实施例用于说明本发明的特征,并非意欲限制本发明的范围。除非另有说明,所有百分比量均为重量/重量百分比(wt/wt%)。
组合物的制备
通过在玻璃罐中合并所有组分并在机械辊上将罐滚动过夜,将实施例的组合物制成60克样品。通过首先在水/醇中制备0.5%至8.0%wt/wt泡沫助洗剂的预混物,将泡沫助洗剂引入混合物中。然后在通过滚动过夜进行混合的步骤前,将适当重量的预混物添加到包含其它组分的混合物中。
根据某些二甲基硅氧烷共聚醇表面活性剂的材料安全性数据表,已知表面活性剂包含大量本文所述类型的PEO/PPO嵌段共聚物作为助洗剂。这些共聚物可以是共聚醇表面活性剂制备过程中的副产物。表1和2列出了实施例组合物中所用的表面活性剂和助洗剂。
表1-表面活性剂
商品名 | INCI名称 | 表面活性剂制造商 | 制造商位置 |
Abil B8852 | PEG/PPG-4/12二甲基硅氧烷 | GoldschmidtChemical Corp. | Hopewell,VA |
Abil B8873 | PEG/PPG-35/65二甲基硅氧烷7,000MW | GoldschmidtChemical Corp. | Hopewell,VA |
Dow190 Fluid1 | PEG/PPG-18/18二甲基硅氧烷 | Dow Corning | Midland,MI |
Dow193 Fluid2 | PEG-12二甲基硅氧烷,羟基封端 | Dow Corning | Midland,MI |
Lambent MFF-164 | 羟基盖帽的二甲基硅氧烷共聚醇 | LambentTechnologies Inc. | Gurnee,IL |
Lambent Quat AD | 硅氧烷季铵盐1 | LambentTechnologies Inc. | Gurnee,IL |
Lambent Quat AM | 硅氧烷季铵盐2(肉豆蔻基) | LambentTechnologies Inc. | Gurnee,IL |
Lambent Syngard300 | 具有二甲基硅氧烷侧链的丙烯酸骨架聚合物 | LambentTechnologies Inc. | Gurnee,IL |
Lambent Wax WS-L | 二甲基硅氧烷共聚醇月桂酸酯 | LambentTechnologies Inc. | Gurnee,IL |
表1-表面活性剂
商品名 | INCI名称 | 表面活性剂制造商 | 制造商位置 |
Lambent Wax WS-p | 硅氧烷共聚醇壬酸酯 | LambentTechnologies Inc. | Gurnee,IL |
Pecosil DCL | 二甲基硅氧烷共聚醇月桂酸酯 | PCI PheonixChemical,Inc. | Somerville,NJ |
Pecosil DCT | 二甲基硅氧烷共聚醇乙酰基甲基牛磺酸钠 | PCI PheonixChemical,Inc. | Somerville,NJ |
Q2-5220Resin Modifier3 | PEG/PPG-17/18二甲基硅氧烷 | Dow Corning | Midland,MI |
Silwax WD-IS | 硅氧烷共聚醇异硬脂酸酯 | LambentTechnologies Inc. | Gurnee,IL |
Silwet77 | PEG二甲基硅氧烷,甲氧基封端,600MW | GE Silicones | Midland,MI |
Silwet L-7001 | EO/PO,甲氧基封端,20,000MW | GE Silicones | Wilton,CT |
Silwet L-7200 | 二甲基硅氧烷共聚醇 | GE Silicones | Midland,MI |
Silwet L-7500 | PPO二甲基硅氧烷,丁氧基封端,3,000MW | GE Silicones | Midland,MI |
Silwet L-7602 | PEG二甲基硅氧烷,甲氧基封端,3000MW | GE Silicones | Wilton,CT |
Silwet L-7604 | PEG二甲基硅氧烷,羟基封端,4000MW | GE Silicones | Midland,MI |
Silwet L-7605 | PEG二甲基硅氧烷,甲氧基封端,6000MW | GE Silicones | Wilton,CT |
Silwet L-7614 | PEG二甲基硅氧烷,羟基封端,5000MW | GE Silicones | Wilton,CT |
3MTM Silicones″Plus″Polymer VS80 | 聚硅氧烷-8 | 3M Company | St.Paul,MN |
1.Dow190表面活性剂包括聚(环氧乙烷,环氧丙烷)单烯丙基醚乙酸酯和聚醚聚醇乙酸酯。
2.Dow193表面活性剂包括聚环氧乙烷单烯丙基醚。
3.Q2-5220树脂改性剂包括聚(环氧乙烷,环氧丙烷)单烯丙基醚乙酸酯;聚乙二醇单烯丙基醚乙酸酯;和聚醚聚醇乙酸酯。
表2-泡沫助洗剂
商品名 | 描述 | 供应商/制造商 | 制造商位置 |
Aqualon EC K100 | 乙基纤维素 | Hercules | Wilmington,DE |
Crothix Liquid | PEG-150四硬脂酸季戊四醇酯(和)PEG-6癸酸/辛酸甘油酯 | Croda | Parsippany,NJ |
Ecopol120-S | 羟丙基瓜尔胶 | EconomyPolymers andChemicals | Houston,TX |
GanexP-904LC | 丁基化的聚乙烯基吡咯烷酮 | ISP Technologies | Wayne,NJ |
Natrosol Plus | 十六烷基羟乙基纤维素 | Hercules | Wilmington,DE |
Plasdone PVP K-120 | 聚乙烯基吡咯烷酮 | InternationalSpecialty Products | Wayne,NJ |
PluronicF-108 | 环氧乙烷/环氧丙烷/嵌段共聚物 | BASF | Florham Park,NJ |
PluronicF-127 | 环氧乙烷/环氧丙烷/嵌段共聚物 | BASF | Florham Park,NJ |
Polyox WSR N12K | 聚(环氧乙烷)平均MW1,000,000 | Dow ChemicalCo. | Midland,MI |
表2-泡沫助洗剂
商品名 | 描述 | 供应商/制造商 | 制造商位置 |
Polyox WSR N60K | 聚(环氧乙烷)平均MW2,000,000 | Dow ChemicalCo. | Midland,MI |
Polyox WSR N-80 | 聚(环氧乙烷)平均MW200,000 | Dow ChemicalCo. | Midland,MI |
Polyox WSR-301 | 聚(环氧乙烷)平均MW4,000,000 | Dow ChemicalCo. | Midland,MI |
PVP K-90 | 聚乙烯基吡咯烷酮(K值90) | BASF | Florham Park,NJ |
设备
泡沫泵--使用泡沫泵喷嘴从各组合物中产生泡沫。所用的泵是泵分配器,产品码F2,F2-L11 255/150型,获自Airspray International Inc.ofNorth Pompano Beach,FL。
泡沫收集瓶--使用小瓶收集来自泵分配器的泡沫,同时测量泡沫高度。小瓶由玻璃制成,高度为40或80mm,内径为25mm,外径为27mm。
试验方法
泡沫高度试验程序
使用泡沫泵评价组合物的泡沫形成性质。通过将水抽吸通过泵直到水变得清澈,在各样品之间用去离子水漂洗泵。将泵浸管从水中取出,然后抽吸干燥残余的水,然后放入要测定的组合物中。然后将泵抽吸3次以准备启动(prime)泵,然后再抽吸3次以将溶液冲洗通过喷嘴,以保证体系备用。最后,通过以每次抽吸约1秒的速率缓慢抽吸,将三次抽吸体积的泡沫收集到收集瓶内。将包含泡沫的小瓶放到平坦的表面上,开启计时器,使用具有毫米增量的小尺子测量泡沫的近似高度,忽略任何剩余未起泡组合物的高度。测量泡沫高度的时间通常为约5秒。产生至少5秒不稳定的泡沫的任何组合物被认为是不稳定的,评分为0mm。将泡沫高度估计为泡沫的平均高度。如果溶液顶部的任何点(通常在中心位置)没有泡沫,则给出0mm的评分。在1、3和5分钟后记录泡沫高度,以确定泡沫的长期稳定性。
泡沫体积增加%
如下计算泡沫体积增加相对于溶液体积的百分比:以毫米测量泡沫的高度,从泡沫高度中减去5mm,将结果除以5(未起泡抽吸溶液的体积),再乘以100%。在产生泡沫后(例如在分配后),立即测量泡沫体积增加%。由于难以确定确切的泡沫表面,所以将0-5mm的泡沫高度报告为泡沫体积增加百分比为零。
粘度
在23℃,在环境压力下,使用配有Brookfield LV心轴#1@60rpm的LVT型Brookfield粘度计,测量粘度,单位为厘泊(cP)。在测量前使所有样品在23℃平衡24小时。在尽可能最低的速度同时处于粘度计范围的10-100%并且更优选范围的20-80%内测量粘度。在测试一分钟后读取粘度。在所有情况下,选择样品尺寸和容器几何学以保证没有壁效应。“壁效应”是指粘度值不受容器的影响,基本上等于在无穷大的容器内测量的粘度。出于这个原因,较低粘度的样品需要更大的样品尺寸来适应更大的心轴。
实施例1-13
使用各种量的表面活性剂Dow190;加上以商品名POLYOX(TM)WSR N12K获自Dow Chemical Company of Midland,MI的聚(环氧乙烷)(PEO)泡沫助洗剂;蒸馏水,和醇溶剂来制备实施例1-13。按照上述试验方法对各样品进行泡沫高度测量。表3列出各实施例的泡沫高度测量和配方。
表3
实施例 | Dow190表面活性剂量% | 泡沫助洗剂N12K量% | 水量% | SDA1(EtOH/IPA) | IPA2 | 初始泡沫高度mm | 1min泡沫高度mm | 3min泡沫高度mm | 5min泡沫高度mm |
1 | 1.00 | 0.060 | 43.94 | 55.00 | - | 32 | 30 | 24 | 23 |
2 | 1.00 | 0.060 | 38.94 | 60.00 | - | 32 | 29 | 28 | 22 |
3 | 1.00 | 0.060 | 35.17 | 63.77 | - | 35 | 33 | 29 | 20 |
4 | 1.00 | 0.060 | 28.94 | 70.00 | - | 34 | 32 | 26 | 18 |
5 | 1.00 | 0.060 | 23.94 | 75.00 | - | 28 | 26 | 21 | 17 |
6 | 1.00 | 0.060 | 18.94 | 80.00 | - | 30 | 29 | 23 | 14 |
7 | 1.00 | 0.060 | 43.94 | - | 55.00 | 36 | 35 | 32 | 28 |
8 | 1.00 | 0.060 | 34.94 | - | 64.00 | 35 | 33 | 29 | 23 |
9 | 0.50 | 0.060 | 35.44 | - | 64.00 | 25 | 23 | 20 | 14 |
10 | 1.00 | 0.060 | 23.94 | - | 75.00 | 17 | 5 | 1 | 0 |
11 | 1.00 | 0.060 | 18.94 | 80.00 | - | 35 | 32 | 25 | 16 |
12 | 1.00 | 0.060 | 8.94 | 90.00 | - | 27 | 23 | 14 | 8 |
13 | 1.00 | 0.060 | 34.94 | 0.00 | 64.003 | 26 | 25 | 21 | 14 |
1.SDA是特制变性醇(SDA-3-C):100份USP200标准强度(proof)的乙醇加5份异丙醇(IPA)的混合物。
2.IPA为异丙醇,试剂级。
3.使用正丙醇(试剂级)代替异丙醇。
实施例14-32
全部使用相同的醇溶剂、泡沫助洗剂、表面活性剂和水含量制备实施例14-32。实施例14-32中唯一的变化是所用表面活性剂的类型。醇溶剂为SDA-3-C,含量为64.00%;泡沫助洗剂为PEO N12K(上列),含量为0.06%;水含量为25.50%,表面活性剂的量为2.50%。表4报告各组合物的泡沫高度数据和泡沫体积增加%数据。
表4
实施例 | 表面活性剂商品名 | 初始泡沫高度mm | 1min泡沫高度mm | 3min泡沫高度mm | 5min泡沫高度mm | 泡沫体积增加% |
14 | Dow190 Fluid | 45 | 42 | 28 | 12 | 800% |
15 | Dow193 Fluid | 30 | 0 | 0 | 0 | 500% |
16 | Abil B8873 | 35 | 31 | 25 | 7 | 600% |
17 | Lambent MFF-164 | 34 | 32 | 28 | 22 | 580% |
18 | Lambent Quat AD | 25 | 7 | 5 | 3 | 400% |
19 | Lambent Quat AM | 30 | 0 | 0 | 0 | 500% |
20 | Lambent Wax WS-L | 30 | 6 | 0 | 0 | 500% |
21 | Lambent Wax WS-p | 35 | 26 | 0 | 0 | 600% |
22 | Pecosil DCL | 34 | 20 | 0 | 0 | 580% |
23 | Pecosil DCT | 15 | 0 | 0 | 0 | 200% |
24 | Q2-5220Resin Modifer(树脂改性剂) | 30 | 27 | 23 | 14 | 500% |
25 | Silwax WD-IS | 10 | 0 | 0 | 0 | 100% |
26 | Silwet77 | 20 | 0 | 0 | 0 | 300% |
27 | Silwet L-7001 | 35 | 34 | 29 | 16 | 600% |
28 | Silwet L-7500 | 10 | 0 | 0 | 0 | 100% |
29 | Silwet L-7602 | 38 | 5 | 0 | 0 | 660% |
30 | Silwet L-7604 | 34 | 0 | 0 | 0 | 580% |
31 | Silwet L-7605 | 30 | 0 | 0 | 0 | 500% |
32 | Silwet L-7614 | 30 | 0 | 0 | 0 | 500% |
实施例33-53和比较例C1-C6
全部使用相同醇含量的65.00%USP200标准强度的乙醇来制备实施例33-53。改变表面活性剂的量和类型、泡沫助洗剂的量和水含量。比较例C1-C4不含表面活性剂。比较例C5和C6不含助洗剂。表5报告了配方、初始泡沫高度测量和泡沫体积增加%。
表5
实施例 | 表面活性剂类型 | 表面活性剂量% | 泡沫助洗剂N12K量% | 水量% | 粘度Cp | 初始泡沫高度mm | 1min泡沫高度mm | 3min泡沫高度mm | 泡沫体积增加% |
C1 | SilwetL-7604 | 0.00 | 0.000 | 35.00 | 3.4 | 0 | 0 | 0 | 0% |
33 | SilwetL-7604 | 0.10 | 0.000 | 34.90 | 3.1 | 5 | 0 | 0 | 0% |
34 | SilwetL-7604 | 1.00 | 0.000 | 34.00 | 3.5 | 10 | 5 | 1 | 100% |
C2 | SilwetL-7604 | 0.00 | 0.060 | 34.94 | 3.8 | 0 | 0 | 0 | 0% |
35 | SilwetL-7604 | 0.10 | 0.060 | 34.84 | 4.1 | 18 | 0 | 0 | 260% |
36 | SilwetL-7604 | 1.00 | 0.060 | 33.94 | 4.0 | 21 | 3 | 0 | 320% |
37 | SilwetL-7604 | 5.00 | 0.060 | 29.94 | 3.9 | 17 | 0 | 0 | 240% |
C3 | SilwetL-7604 | 0.00 | 0.200 | 34.80 | 5.6 | 0 | 0 | 0 | 0% |
38 | SilwetL-7604 | 0.10 | 0.200 | 34.70 | 5.5 | 18 | 0 | 0 | 260% |
39 | SilwetL-7604 | 1.00 | 0.200 | 33.80 | 4.9 | 23 | 18 | 0 | 360% |
C4 | SilwetL-7604 | 0.00 | 0.500 | 34.50 | 15.4 | 0 | 0 | 0 | 0% |
40 | SilwetL-7604 | 0.10 | 0.500 | 34.40 | 16.5 | 16 | 0 | 0 | 220% |
41 | Dow190 | 1.00 | 0.060 | 33.94 | 3.9 | 40 | 38 | 35 | 700% |
42 | Dow190 | 1.00 | 0.000 | 34.00 | 1.5 | 15 | 9 | 6 | 200% |
43 | Lambent AD | 1.00 | 0.060 | 33.94 | 4.0 | 20 | 0 | 0 | 300% |
C5 | Lambent AD | 1.00 | 0.000 | 34.00 | 3.1 | 0 | 0 | 0 | 0% |
44 | Lambent WS-P | 1.00 | 0.060 | 33.94 | 4.1 | 34 | 30 | 8 | 580% |
45 | Lambent WS-P | 1.00 | 0.000 | 34.00 | 3.0 | 11 | 8 | 3 | 120% |
46 | MFF-164 | 1.00 | 0.060 | 33.94 | 3.0 | 35 | 34 | 32 | 600% |
47 | MFF-164 | 1.00 | 0.000 | 34.00 | 2.5 | 14 | 10 | 7 | 180% |
48 | PecosilDCT | 1.00 | 0.060 | 33.94 | 3.5 | 10 | 0 | 0 | 100% |
C6 | PecosilDCT | 1.00 | 0.000 | 34.00 | 3.0 | 0 | 0 | 0 | 0% |
49 | SilwetL-7604 | 1.00 | 0.500 | 33.50 | 16.0 | 17 | 13 | 0 | 240% |
50 | Lambent Syngard300 | 1.00 | 0.060 | 34.94 | nt1 | 33 | 32 | 30 | 560% |
51 | Abil B8852 | 1.00 | 0.060 | 34.94 | nt | 34 | 34 | 20 | 580% |
52 | Silwet L-7200 | 1.00 | 0.060 | 34.94 | nt | 37 | 39 | 32 | 640% |
53 | 3M VS80 | 1.00 | 0.060 | 34.94 | nt | 26 | 18 | 14 | 420% |
1.“nt”-未检测
实施例54-64
全部使用相同醇含量的65.00%USP200标准强度的乙醇和相同表面活性剂含量的1.00%Q2-5220树脂改性剂来制备实施例54-64。改变泡沫助洗剂的量和类型,水含量也如此。表6报告组成、泡沫高度和泡沫体积增加%。
表6
实施例 | 泡沫助洗剂类型 | 泡沫助洗剂量% | 水量% | 粘度Cp | 初始泡沫高度mm | 1min泡沫高度mm | 3min泡沫高度mm | 5min泡沫高度mm | 泡沫体积增加% |
54 | 无 | 0.000 | 34.00 | nt1 | 10 | 9 | 7 | 6 | 100% |
55 | Crothix | 0.080 | 33.92 | nt | 12 | 10 | 7 | 7 | 140% |
56 | Crothix | 0.300 | 33.70 | 4.9 | 12 | 9 | 8 | 6 | 140% |
57 | GanexP-904LC | 0.080 | 33.92 | nt | 11 | 9 | 8 | 8 | 120% |
58 | GanexP-904LC | 0.300 | 33.70 | 7.4 | 10 | 8 | 8 | 7 | 100% |
59 | PluronicF-108 | 0.080 | 33.92 | nt | 10 | 7 | 6 | 6 | 100% |
60 | PluronicF-108 | 0.300 | 33.70 | 3.1 | 10 | 9 | 7 | 7 | 100% |
61 | PluronicF-127 | 0.080 | 33.92 | nt | 11 | 9 | 7 | 6 | 120% |
62 | PluronicF-127 | 0.300 | 33.70 | 8.6 | 13 | 10 | 9 | 9 | 160% |
63 | PVP K-90 | 0.080 | 33.92 | nt | 13 | 10 | 9 | 7 | 160% |
64 | PVP K-90 | 0.300 | 33.70 | 4.3 | 9 | 9 | 6 | 6 | 80% |
1.“nt”-未检测
实施例65-73
全部使用相同表面活性剂含量的1.00%Dow190制备实施例65-73。泡沫助洗剂的量、水含量和USP200标准强度的乙醇全部改变。此外还改变了泡沫助洗剂的类型。表7报告了组成、泡沫高度和泡沫体积增加%。
表7
实施例 | 泡沫助洗剂类型 | 泡沫助洗剂量% | 水量% | EtOH量% | 初始泡沫高度mm | 1min泡沫高度mm | 3min泡沫高度mm | 5min泡沫高度mm | 泡沫体积增加% |
65 | 无 | 0 | 34.00 | 65.00 | 15 | 13 | 11 | 9 | 200% |
66 | NatrosolPlus | 0.06 | 33.98 | 64.96 | 13 | 10 | 8 | 6 | 160% |
67 | NatrosolPlus | 0.35 | 33.88 | 64.77 | 6 | 6 | 4 | 4 | 20% |
68 | Aqualon ECK100 | 0.06 | 33.98 | 64.96 | 15 | 11 | 10 | 8 | 200% |
69 | Aqualon ECK100 | 0.35 | 33.88 | 64.77 | 13 | 10 | 8 | 8 | 160% |
70 | Ecopol120-S | 0.06 | 33.98 | 64.96 | 12 | 9 | 8 | 7 | 140% |
71 | Ecopol120-S | 0.35 | 33.88 | 64.77 | 17 | 15 | 14 | 11 | 240% |
72 | PVP K-120 | 0.06 | 33.98 | 64.96 | 14 | 11 | 9 | 8 | 180% |
73 | PVP K-120 | 0.35 | 33.88 | 64.77 | 9 | 7 | 6 | 6 | 80% |
实施例74-78
使用不同分子量的PEO助洗剂配制实施例74-78。对于所有的实施例68-72,使用1.00%量的Dow190作为表面活性剂。表7报告配方信息和泡沫高度数据。流体量为1.00%。
表8
实施例 | PEO泡沫助洗剂类型 | PEO泡沫助洗剂MW | 泡沫助洗剂量% | 水量% | 醇溶剂量%1 | 初始泡沫高度mm | 1min泡沫高度mm | 3min泡沫高度mm | 5min泡沫高度mm |
74 | WSR-301 | 4,000,000 | 0.060 | 29.94 | 69.00 | 22 | 15 | 10 | 8 |
75 | N60K | 2,000,000 | 0.060 | 29.94 | 69.00 | 28 | 24 | 20 | 14 |
76 | N12K | 1,000,000 | 0.060 | 29.94 | 69.00 | 26 | 24 | 20 | 16 |
77 | WSRN-80 | 200,000 | 0.060 | 34.94 | 64.00 | 14 | 13 | 11 | 9 |
78 | 无 | 0 | 0.0 | 35.00 | 64.00 | 9 | 9 | 8 | 8 |
1.实施例68-70的醇为190标准强度的USP乙醇。实施例71-72的醇为SDA-3-C醇溶剂。
第二抗微生物剂
表9列出可以添加到实施例73-76所述的配方中的各种额外(除醇以外的第二种)抗微生物剂。
表9
简写名 | 描述 | 供应商/制造商 | 制造商位置 |
CHG | 20%葡萄糖酸氯己定溶液 | Medichem,S.A,由George UheCompany,Inc.分装 | Paramus,NJ |
PCMX | 对氯间二甲苯酚 | Ferro Corporation | Cleveland,OH |
Triclosan | IRGASANDP300 | Ciba | Greensboro,NC |
Citric Acid | 柠檬酸 | MCB Reagents | Rahway,NJ |
GML | 甘油单月桂酸酯 | Med-Chem Labs | Galena,IL |
SCL | 癸酸乳酸钠 | Rita Corp. | Woodstock,IL |
实施例79-82
用相同的组分配制实施例79-82,除了使用不同的第二抗微生物剂,如表10所示。表10还列出泡沫高度和泡沫体积增加%。
表10
实施例 | 表面活性剂Dow190量% | 泡沫助洗剂WSR-N12K | 水量% | 醇SDA-3-C量% | 第二抗微生物剂 | 抗微生物剂量% | 初始泡沫高度mm | 5min泡沫高度mm | 泡沫体积增加% |
79 | 1.00 | 0.060 | 34.17 | 63.77 | CHG | 1.00 | 35 | 15 | 600% |
80 | 1.00 | 0.060 | 34.17 | 63.77 | PCMX | 1.00 | 40 | 15 | 700% |
81 | 1.00 | 0.060 | 34.17 | 63.77 | Triclosan | 1.00 | 36 | 12 | 620% |
82 | 1.00 | 0.060 | 31.97 | 63.77 | GML+CA+SCL1 | 1.00 | 26 | 2 | 420% |
1.1.00%甘油单月桂酸酯+2.00%柠檬酸+0.1%capril lactylate钠
实施例83-107
制备实施例83-107,使其具有相同醇含量的69.00%USP190标准强度的乙醇。按表11所述的各种量使用Dow190表面活性剂和WSR-301泡沫助洗剂。此外,向各配方中添加一种或多种润肤剂。表11报告了配方、初始泡沫高度测量和泡沫体积增加%。
表11
实施例 | 表面活性剂Dow190量% | 泡沫助洗剂WSR301量% | 水量% | M11 | M22 | M33 | 初始泡沫高度mm | 1min泡沫高度mm | 3min泡沫高度mm | 泡沫体积增加% |
83 | 1.00 | 0.06 | 28.94 | 1.00 | 0.00 | 0.00 | 24 | 18 | 14 | 380% |
84 | 3.00 | 0.01 | 26.50 | 0.50 | 0.00 | 1.00 | 15 | 12 | 10 | 200% |
85 | 2.00 | 0.01 | 26.00 | 1.00 | 1.00 | 1.00 | 17 | 14 | 10 | 240% |
86 | 1.00 | 0.06 | 27.94 | 1.00 | 1.00 | 0.00 | 20 | 15 | 10 | 300% |
87 | 3.00 | 0.06 | 26.00 | 0.00 | 1.44 | 0.50 | 29 | 25 | 22 | 480% |
88 | 1.49 | 0.04 | 26.49 | 0.50 | 2.00 | 0.50 | 30 | 28 | 26 | 500% |
89 | 3.00 | 0.04 | 26.00 | 0.00 | 0.97 | 1.00 | 34 | 31 | 24 | 580% |
90 | 1.00 | 0.01 | 27.99 | 0.00 | 1.00 | 1.00 | 12 | 9 | 8 | 140% |
91 | 1.00 | 0.01 | 27.99 | 1.00 | 0.00 | 1.00 | 14 | 9 | 8 | 180% |
92 | 1.00 | 0.01 | 29.00 | 0.50 | 0.50 | 0.00 | 15 | 10 | 8 | 200% |
93 | 3.00 | 0.06 | 26.00 | 1.00 | 0.94 | 0.00 | 25 | 20 | 18 | 400% |
94 | 1.94 | 0.06 | 26.00 | 1.00 | 2.00 | 0.00 | 30 | 28 | 23 | 500% |
95 | 1.00 | 0.06 | 28.94 | 0.00 | 0.00 | 1.00 | 27 | 22 | 16 | 440% |
96 | 1.00 | 0.01 | 26.99 | 1.00 | 2.00 | 0.00 | 15 | 11 | 9 | 200% |
97 | 1.50 | 0.01 | 29.00 | 0.00 | 0.00 | 0.50 | 15 | 10 | 10 | 200% |
98 | 3.00 | 0.01 | 26.00 | 0.00 | 1.99 | 0.00 | 15 | 13 | 9 | 200% |
99 | 2.97 | 0.06 | 26.00 | 1.00 | 0.00 | 0.97 | 25 | 23 | 18 | 400% |
100 | 3.00 | 0.01 | 26.00 | 0.00 | 1.99 | 0.00 | 16 | 14 | 12 | 220% |
101 | 2.00 | 0.06 | 27.94 | 0.00 | 0.00 | 1.00 | 30 | 22 | 17 | 500% |
102 | 1.91 | 0.06 | 27.10 | 0.51 | 0.91 | 0.51 | 36 | 31 | 25 | 620% |
103 | 1.00 | 0.01 | 26.99 | 0.00 | 2.00 | 1.00 | 14 | 10 | 7 | 180% |
104 | 1.00 | 0.06 | 27.94 | 0.00 | 2.00 | 0.00 | 30 | 25 | 21 | 500% |
105 | 3.00 | 0.01 | 26.99 | 1.00 | 0.00 | 0.00 | 15 | 12 | 8 | 200% |
106 | 1.00 | 0.06 | 26.00 | 0.97 | 1.97 | 1.00 | 31 | 30 | 25 | 520% |
107 | 2.00 | 0.06 | 27.94 | 1.00 | 0.00 | 0.00 | 31 | 28 | 20 | 520% |
1.M1为肉豆蔻醇,获自Sasol North America,Westlake,LA。
2.M2为G-18-0,甘油聚醚18己酸乙酯,获自Global7,Franklin,NJ。
3.M3为甘油,获自Dow Chemical,Midland MI。
实施例108-113
使用63.77%SDA-3-C的相同醇含量;相同量的1.00%表面活性剂Dow190和量为0.060%的相同泡沫助洗剂PEO N12K制备实施例108-113。改变润肤剂的类型和量,水的量也是如此。取得初始泡沫高度测量和泡沫体积增加%并报告于表12中。
表12
实施例 | 水量% | M11 | M42 | M53 | 初始泡沫高度mm | 1min泡沫高度mm | 3min泡沫高度mm | 5min泡沫高度mm | 泡沫体积增加% |
108 | 34.67 | 0.50 | 0.00 | 0.00 | 38 | 33 | 28 | 18 | 660% |
109 | 34.17 | 1.00 | 0.00 | 0.00 | 37 | 34 | 23 | 13 | 640% |
110 | 33.17 | 2.00 | 0.00 | 0.00 | 30 | 28 | 24 | 15 | 500% |
111 | 32.17 | 3.00 | 0.00 | 0.00 | 30 | 24 | 24 | 15 | 500% |
112 | 32.17 | 0.00 | 3.00 | 0.00 | 36 | 35 | 30 | 21 | 620% |
113 | 32.17 | 0.00 | 0.00 | 3.00 | 35 | 34 | 26 | 15 | 600% |
1.M1:肉豆蔻醇,获自Sasol North America,Westlake,LA。
2.M4:柠檬酸三乙酯,NF,获自Morflex Inc.of Greensboro,NC。
3.M5:乙酰基柠檬酸三乙酯,NF,获自Morflex Inc.of Greensboro,NC。
表13比较例C7-C16的组分
商品名/简写名 | 描述 | 供应商/制造商 | 制造商位置 |
Monateric CAB-NPB | 椰油酰胺基丙基甜菜碱 | Uniqema | Wilmington,DE |
BRIJ52 | PEO2十六醇 | Uniqema | Wilmington,DE |
Silwet L-7200 | 二甲基硅氧烷共聚醇MW19,000,EO/PO比率75/25 | GE Silicones | Midland,MI |
Standamid KD | 椰油酰胺DEA | Kraft Chemical Co. | Melrose Park,IL |
Super Solen PEG-75 | PEG-75羊毛脂 | Croda | Parsippany,NJ |
Myristyl Alcohol | 肉豆蔻醇 | Sasol | Westlake,LA |
Tween61 | PEO4失水山梨糖醇单硬脂酸酯 | Uniqema | Wilmington,DE |
Dermal DIA | 己二酸二异丙酯 | Alzo International | Sayreville,NJ |
Cetearyl alcohol | 十六醇和十八醇的50∶50wt共混物 | Croda | Parsippany,NJ |
PG | 丙二醇 | Dow Chemical | Midland,MI |
Methocel40-100 | 羟丙基甲基纤维素 | Dow Chemical | Midland,MI |
Klucel | 羟丙基纤维素 | Hercules | Wilmington,DE |
Ritapro300 | 十六醇和十六醇聚醚-20 | Rita Corp. | Woodstock,IL |
Brij72 | 硬脂醇聚醚-2 | Uniqema | Wilmington,DE |
Brij721 | 硬脂醇聚醚-21 | Uniqema | Wilmington,DE |
Polysorbate80 | 聚山梨醇酯80 | Sigma Chemical Co. | St.Louis,MO |
PEG400 | 聚乙二醇400MW | Dow Chemical | Midland,MI |
Sodium Dodecylbenzene sulfonate | 十二烷基苯磺酸钠 | Pfaltz and Bauer | Waterbury,CT |
Citric Acid | 柠檬酸 | MCB Reagents | Rahway,NJ |
Glycerol monolaurate | 甘油单月桂酸酯 | Med-Chem Labs | Galena,IL |
Sodium CaprilLactylate | 癸酸乳酸钠 | Rita Corp. | Woodstock,IL |
比较例C7-C8
在使用表13的材料以表14A和14B所列的量制备后,测试比较例C7和C8的初始泡沫高度。
表14A
实施例 | CHG溶液20% | 十六醇 | Tween61 | PG | USP乙醇190标准强度 | 水 | 初始泡沫高度mm |
C7 | 5.00 | 2.50 | 0.50 | 3.00 | 57.00 | 22.80 | 0 |
表14B
实施例 | 肉豆蔻醇 | Brij52 | 甘油 | IPA | 水 | 初始泡沫高度mm |
C8 | 3.00 | 0.80 | 2.50 | 60.00 | 25.40 | 0 |
比较例C9-C11
使用表13所列的材料,以表15所列的量制备比较例C9、C10和C11,并根据上述标准泡沫高度程序测试。比较例C9-C11各自的初始泡沫高度为0mm。
表15
实施例# | SilwetL-7200 | 椰油酰胺基丙基甜菜碱 | KraftStandamidKD | Methocel40-100 | PEG-75羊毛脂 | 甘油 | IPA | USP乙醇200标准强度 | 水 |
C9 | 0.20 | 10.00 | 7.00 | 1.00 | 3.00 | 0.20 | - | 60.00 | 17.97 |
C10 | 0.25 | 10.00 | 7.00 | 1.00 | 3.00 | 0.05 | - | 60.00 | 18.07 |
C11 | 0.25 | 10.00 | 7.00 | 1.00 | 3.00 | 0.05 | 70.0 | - | 8.07 |
比较例C12-C14
使用表13所列的材料,以表16所列的量制备比较例C12、C13和C14,并根据上述标准泡沫高度程序测试。
表16
实施例# | Ritapro300 | Brij72 | Brij721 | Klucel | USP乙醇200标准强度 | 水 | CHG20%溶液 | 初始泡沫高度mm |
C12 | 2.50 | 1.88 | 0.625 | 0.20 | 60.00 | 14.62 | 0.060 | 0 |
C13 | 2.50 | 1.88 | 0.625 | 0.20 | 60.00 | 24.71 | 0.200 | 0 |
C14 | 2.50 | 1.88 | 0.625 | 0.20 | 60.00 | 32.23 | 0.200 | 0 |
比较例C15-C16
使用表13所列的各种材料,以表17所列的量制备比较例C15和C16,并根据上述标准泡沫高度程序测定。
表17
实施例# | 十二烷基苯磺酸钠 | 聚山梨醇酯80 | 甘油 | PEG400 | 丙二醇 | USP乙醇标准强度 | 水 | 初始泡沫高度mm |
C15 | 3.00 | 1.00 | 1.50 | 0.50 | 0.00 | 55.00 | 37.25 | 0 |
C16 | 3.00 | 3.00 | 0.00 | 0.00 | 2.00 | 60.00 | 31.00 | 0 |
在不背离本发明范围和精神的情况下,本发明的各种修改和替代对本领域技术人员将是显而易见的。本申请所述的实施例说明了改变组成的类型、数量和比率的可能性以及制备本发明配方的方法。
Claims (19)
1.一种组合物,包括:
(A)其量足以提供抗微生物活性的一元醇;
(B)包括二甲基硅氧烷表面活性剂的表面活性剂;和
(C)助洗剂,所述助洗剂的量足够为由所述组合物形成的泡沫提供稳定性或改进稳定性。
2.如权利要求1所述的组合物,其中一元醇选自:乙醇、丙醇、丁醇、和上述两种或多种醇的组合。
3.如权利要求2所述的组合物,其中一元醇以约35wt%至约99.5wt%的浓度存在于组合物中。
4.如权利要求1所述的组合物,其中表面活性剂以约0.1wt%至约10wt%的浓度存在于组合物中。
5.如权利要求1所述的组合物,其中二甲基硅氧烷表面活性剂选自:甲氧基封端的聚乙二醇二甲基硅氧烷,其平均分子量为约3000;具有35/65(w/w)聚乙二醇/聚丙二醇共聚物的侧醚的二甲基硅氧烷,其合并的平均分子量为约7,000;具有18/18(摩尔比)聚乙二醇/聚丙二醇的聚二甲基硅氧烷共聚醇;具有17/18(摩尔比)聚乙二醇/聚丙二醇的聚二甲基硅氧烷共聚醇;具有甲氧基封端的聚乙二醇/聚丙二醇的聚二甲基硅氧烷共聚醇,其平均分子量为约20,000,亲水亲油平衡值为9-12;具有甲氧基封端的聚乙二醇的聚二甲基硅氧烷共聚醇,其合并的平均分子量为约3000;具有甲氧基封端的聚乙二醇的聚二甲基硅氧烷共聚醇,其合并的平均分子量为约6000;具有羟基封端的聚乙二醇的聚二甲基硅氧烷共聚醇,其合并的平均分子量为约5000,亲水亲油平衡值为13-17;二甲基硅氧烷共聚醇乳酸酯;硅氧烷共聚醇壬酸酯;羟基封闭的聚二甲基硅氧烷共聚醇;羟基封端的聚乙二醇-12二甲基硅氧烷;二甲基硅氧烷共聚醇月桂酸酯;硅氧烷季铵盐1;羟基封端的聚乙二醇二甲基硅氧烷,其平均分子量为约4000;甲氧基封端的聚乙二醇二甲基硅氧烷,其平均分子量为约600;硅氧烷季铵盐2(肉豆蔻基);二甲基硅氧烷共聚醇乙酰基甲基牛磺酸钠;丁氧基封端的聚(环氧丙烷)二甲基硅氧烷,其平均分子量为约3,000;二甲基硅氧烷共聚醇异硬脂酸酯;和上述两种或多种物质的组合。
6.如权利要求1所述的组合物,其中二甲基硅氧烷表面活性剂选自:二甲基硅氧烷双氨基羟基丙基共聚醇、二甲基硅氧烷共聚醇乙酸酯、二甲基硅氧烷共聚醇己二酸酯、二甲基硅氧烷共聚醇杏仁油酸酯、二甲基硅氧烷共聚醇胺、二甲基硅氧烷共聚醇鳄梨油酸酯、二甲基硅氧烷共聚醇蜂蜡、二甲基硅氧烷共聚醇山嵛酸酯、二甲基硅氧烷共聚醇苯甲酸酯、二甲基硅氧烷共聚醇双羟基乙胺、二甲基硅氧烷共聚醇borageate、二甲基硅氧烷共聚醇丁基醚、二甲基硅氧烷共聚醇可可脂酸酯、二甲基硅氧烷共聚醇交联聚合物、二甲基硅氧烷共聚醇dhupabutterate、二甲基硅氧烷共聚醇乙基醚、二甲基硅氧烷共聚醇羟基硬脂酸酯、二甲基硅氧烷共聚醇异硬脂酸酯、二甲基硅氧烷共聚醇kokumbutterate、二甲基硅氧烷共聚醇乳酸酯、二甲基硅氧烷共聚醇月桂酸酯、二甲基硅氧烷共聚醇芒果脂酸酯、二甲基硅氧烷共聚醇meadowfoamate、二甲基硅氧烷共聚醇甲基醚、二甲基硅氧烷共聚醇mohwa butterate、二甲基硅氧烷共聚醇辛基十二烷基柠檬酸酯、二甲基硅氧烷共聚醇橄榄油酸酯、二甲基硅氧烷共聚醇磷酸酯、二甲基硅氧烷共聚醇邻苯二甲酸酯、二甲基硅氧烷共聚醇sal butterate、二甲基硅氧烷共聚醇shea butterate、二甲基硅氧烷共聚醇硬脂酸酯、二甲基硅氧烷共聚醇十一烯酸酯、二甲基硅氧烷羟基丙基三甲基氯化铵、二甲基硅氧烷丙基pg-甜菜碱、聚硅氧烷-10、聚硅氧烷-8、二甲基硅氧烷丙基乙二胺山嵛酸酯、氨基双丙基二甲基硅氧烷氨基乙基氨基丙基二甲基硅氧烷、山嵛基三甲基铵二甲基硅氧烷共聚醇邻苯二甲酸酯、双-氨基丙基共聚醇氨基丙基二甲基硅氧烷、双-羟基乙氧基丙基二甲基硅氧烷、十六烷基三乙基铵二甲基硅氧烷共聚醇琥珀酸酯、二甲基硅氧烷共聚醇硫酸酯、二甲基硅氧烷共聚醇磷酸酯、二甲基硅氧烷聚甘油、共聚醇二甲基硅氧烷磺基琥珀酸二钠、共聚醇聚二甲基甲硅氧烷基乙基二甲基硅氧烷、共聚醇pg-可可-葡糖苷二甲基硅氧烷、共聚醇九氟己基二甲基硅氧烷共聚物、共聚醇甲基醚月桂氧基peg酰胺基丙基二甲基硅氧烷、共聚醇油基醚二甲基硅氧烷、羧基癸基共聚醇二甲基硅氧烷钠、和上述两种或多种物质的组合。
7.如权利要求1所述的组合物,其中二甲基硅氧烷表面活性剂包括摩尔比为约18/18的聚乙二醇和聚丙二醇。
8.如权利要求1所述的组合物,其中助洗剂选自:分子量为约100,000至10,000,000的聚(环氧乙烷)、聚乙烯-聚丙烯共聚物、羟乙基纤维素、羟丙基纤维素和上述两种或多种物质的组合,且其中助洗剂以约0.001wt%至约5wt%的浓度存在于组合物中。
9.如权利要求1所述的组合物,其中助洗剂选自:羟丙基瓜尔胶、聚季铵盐-4、聚季铵盐-10、十六烷基羟乙基纤维素、乙基羟基乙基纤维素、聚甘油、高分子量polyoxamer、高分子量polyoxamine、聚丙烯酰胺、具有烷基醇或酸官能烷基的高分子量聚乙二醇酯和醚、聚丙烯酰胺基甲基丙烷磺酸、聚丙烯酸、聚乙烯/马来酸异丙酯/马来酸共聚醇、聚甲基丙烯酰胺基丙基三甲基氯化铵、聚甲基丙烯酰胺基丙基三甲基甲硫酸铵、聚甲基丙烯酸、聚季铵盐-1至聚季铵盐-47、聚乙烯基甲基醚、丁基化的聚乙烯基吡咯烷酮、羟丙基甲基纤维素;羟丙基纤维素;包含n-乙烯基内酰胺单体单元的交联和未交联的均聚物或交联和未交联的共聚物、和上述两种或多种物质的组合。
10.如权利要求1所述的组合物,还包括润肤剂,其中该润肤剂以约30wt%或更少的浓度存在于组合物中。
11.如权利要求1所述的组合物,还包括第二抗微生物剂,所述第二抗微生物剂以高至约10wt%的浓度存在于组合物中,所述第二抗微生物剂选自:对氯间二甲苯酚;三氯生;氯己定及其盐,聚亚己基双胍及其盐、碘、碘递体;脂肪酸单酯;聚-n-乙烯基吡咯烷酸-碘递体;氧化银、银及其盐、过氧化物、抗生素、和上述两种或多种物质的组合。
12.如权利要求1所述的组合物,还包括量为约0.1wt%至60wt%的一种或多种皮肤屏障材料,其中所述屏障材料选自:尿囊素铝、尿囊素、醋酸铝、氢氧化铝、碱式硝酸铋、硼酸、炉甘石、纤维素、维生素D3、可可脂、鱼肝油、胶状燕麦片、盐酸半胱氨酸、右泛醇、二甲基硅氧烷、甘油高岭土、羊毛脂、活酵母细胞衍生物、矿物油、秘鲁香脂、秘鲁香脂油、矿脂、蛋白质水解产物、消旋蛋氨酸、鲨鱼肝油、碳酸氢钠、硫、滑石、单宁酸、局部淀粉、维生素A、白矿脂、醋酸锌、碳酸锌、氧化锌、和上述两种或多种物质的组合。
13.如权利要求1所述的组合物,还包括抗真菌剂。
14.如权利要求1所述的组合物,其中在起泡前,组合物在23℃的粘度处于约0.5至约100cps的范围内。
15.如权利要求1所述的组合物,还包括选自下列的推进剂:氯氟碳、氢氯氟碳、氢氟碳、全氟化的烷烃、具有C1-C5碳链长度的低级烷烃、一氧化二氮二甲基醚、和上述两种或多种物质的组合。
16.一种包括容器和如权利要求11所述的组合物的体系,在压力下将所述组合物包含在容器内,推进剂以约2%至约30%体积比的浓度存在于组合物内。
17.一种体系,包括:
包括贮库和手动泵的分配器;和
包含在所述贮库内的权利要求1的组合物。
18.一种皮肤消毒剂,包括权利要求1的组合物。
19.一种术前擦手物,包括权利要求1的组合物。
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PCT/US2006/021904 WO2006138111A1 (en) | 2005-06-13 | 2006-06-06 | Foamable alcohol compositions, systems and methods of use |
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-
2005
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-
2006
- 2006-06-06 EP EP06772279A patent/EP1893167A1/en not_active Withdrawn
- 2006-06-06 CN CN2006800212051A patent/CN101198308B/zh active Active
- 2006-06-06 KR KR1020077029560A patent/KR101389199B1/ko not_active IP Right Cessation
- 2006-06-06 AU AU2006259687A patent/AU2006259687B2/en active Active
- 2006-06-06 WO PCT/US2006/021904 patent/WO2006138111A1/en active Application Filing
- 2006-06-06 MX MX2007015768A patent/MX2007015768A/es active IP Right Grant
- 2006-06-06 JP JP2008516932A patent/JP5266049B2/ja not_active Expired - Fee Related
- 2006-06-06 BR BRPI0613333-9A patent/BRPI0613333A2/pt not_active IP Right Cessation
- 2006-06-06 CA CA2610945A patent/CA2610945C/en active Active
- 2006-06-12 TW TW095120904A patent/TW200710220A/zh unknown
-
2008
- 2008-01-14 NO NO20080261A patent/NO20080261L/no not_active Application Discontinuation
-
2009
- 2009-09-01 US US12/552,126 patent/US20090326076A1/en not_active Abandoned
-
2010
- 2010-09-09 US US12/878,786 patent/US20100331411A1/en not_active Abandoned
- 2010-09-09 US US12/878,793 patent/US20100327013A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
CN101198308B (zh) | 2013-04-10 |
EP1893167A1 (en) | 2008-03-05 |
JP2008546692A (ja) | 2008-12-25 |
TW200710220A (en) | 2007-03-16 |
AU2006259687A1 (en) | 2006-12-28 |
MX2007015768A (es) | 2008-02-15 |
CA2610945A1 (en) | 2006-12-28 |
US7651990B2 (en) | 2010-01-26 |
US20100327013A1 (en) | 2010-12-30 |
US20060281663A1 (en) | 2006-12-14 |
US20100331411A1 (en) | 2010-12-30 |
KR20080026546A (ko) | 2008-03-25 |
NO20080261L (no) | 2008-03-10 |
WO2006138111A1 (en) | 2006-12-28 |
JP5266049B2 (ja) | 2013-08-21 |
CA2610945C (en) | 2016-06-28 |
BRPI0613333A2 (pt) | 2011-01-04 |
US20090326076A1 (en) | 2009-12-31 |
KR101389199B1 (ko) | 2014-04-24 |
AU2006259687B2 (en) | 2012-03-08 |
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Effective date of registration: 20240408 Address after: U.S.A. Patentee after: Shuwanuo Intellectual Property Co. Country or region after: U.S.A. Address before: American Minnesota Patentee before: 3M INNOVATIVE PROPERTIES Co. Country or region before: U.S.A. |