CN1011919B - 测定分析物的最少的操作步骤系统 - Google Patents

测定分析物的最少的操作步骤系统

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CN1011919B
CN1011919B CN87106256A CN87106256A CN1011919B CN 1011919 B CN1011919 B CN 1011919B CN 87106256 A CN87106256 A CN 87106256A CN 87106256 A CN87106256 A CN 87106256A CN 1011919 B CN1011919 B CN 1011919B
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罗杰·菲利浦斯
杰弗里·麦加劳
弗兰克·朱里克
雷·安德伍德
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Life Scan Ltd
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Abstract

本发明公开了测定液体中分析物的方法,以及为实施该方法而专门设计的仪器的各个组成部分。本方法包括:从浸有试剂的惰性多孔基体一个表面取得反射比读数,该试剂是在将被分析的液体涂到该基体的另一表面并迁移过基体而到达所读取读数的表面时与分析物起反应,产生吸光的反应产物。为了消除干扰,反射比测量是用两个不同的波长进行的,计时电路是由被分析的液体通过惰性基体使测量反射比的表面润湿,进而使反射比开始下降来启动的。本发明的方法和仪器特别适用于测量血糖水平,而无需将红血细胞与血清或血浆分离。

Description

本发明涉及比色测定含水液体尤其是全血中化学和生物化学组分(分析物)的测试装置和方法。在一个最佳实施例中,还涉及比色测定全血中葡萄糖浓度的测试装置和方法。
定量测定有色含水液体尤其是有色生物液体如全血和尿以及生物液体衍化物如血清和血浆中化学和生物化学组分的重要性日益增加。其重要用途在于内科诊断和治疗以及定量表示接触治疗药物、中毒剂、危险化学药品等的数量。在某些情况下,所测物质的量非常微小-在微克/分升或更少的范围内-或非常难以精密测定以至所使用的仪器是复杂的而且只有熟练的实验室工作人员才能操作。在这种情况下,往往在抽样后数小时或数日还不能得到结果。在其他一些情况下,往往是强调非专业操作者能够在实验室外进行常规的、快速的和具有重现性的测试,而迅速或直接得到数据的能力。
一种常用的医学检验是由糖尿病患者测定血糖水平。目前的学说,指导糖尿病患者按各自病情的性质和严重程度,每天测定他们的血糖水平2至7次。根据所测葡萄糖水平的观察模式,患者和医生共同调整饮食、锻练和服用胰岛素,以改善对疾病的治疗。显然,此种资料应立即提供给患者。
最近,在美国广泛应用的一种方法,是采用Mast在1967年1月17日公开的美国专利第3298789号中所介绍的一种测试装置。在该方法中,将新鲜的全血样品(通常为20~40微升)置于涂有乙基纤维素的试剂垫上,该垫含有葡萄糖氧化酶和过氧化物酶活性的酶系统。此酶系统与葡 萄糖反应,释放出过氧化氢。该垫还含有指示剂,此指示剂在有过氧化物酶存在的情况下与过氧化氢反应,得到一种强度与血样葡萄糖水平成正比的颜色。
另一种普及的血糖测定方法是应用相似的化学原理,但不用涂有乙基纤维素的垫,而是采用抗水薄膜,通过该薄膜而使酶和指示剂分散。这种类型的系统已公开在Rey等人1971年12月28日出版的美国专利第3630957号中。
在上述两种情况下,均使血样与试剂垫保持接触一段特定的时间(一般为1分钟)。然后,将前者的血样用水流冲洗,而后者的血样则是从膜上擦去。然后再将试剂垫或薄膜吸干和进行测定。测定的方法是将所显颜色与比色图表对比,或者将该垫或薄膜放在漫反射仪中,读出显色强度值。
上述测定葡萄糖的方法已使用多年,确实存在一定的局限性。做一次扎手指取血试验(finger    stick    test)需要的样品量相当大,而且对某些毛细管血液不易挤出来的人而言很难获得成功。
此外,这些方法与其他非专业操作者进行的简单比色测定具有共同局限性,因为其结果是以绝对显色读数为基准的,而此种绝对显色读数又与样品和试验试剂之间的绝对反应程度有关。在定时反应时间间隔后必须将样品从试剂垫上洗去或擦去的事实,要求使用者在每次定时间隔的末尾就作好准备,及时擦净,或用水流冲洗。除去样品后反应即终止的事实,可导致结果不太准确,尤其是对于家庭用户来说。冲洗过度,结果偏低,冲洗不足,则结果偏高。
在非专业操作者进行的简单比色测定中经常存在的另一个问题,是将血液涂在试剂垫上时,就需要开始计时顺序。使用者一般用扎手指针取得血液样品,然后要求在其另一只手开始计时工序的同时,将从手指上取得的血液涂到试剂垫上去,因而需要双手同时进行操作。由于经常 需要保证在血液刚被涂到试剂垫上时就立即开始计时,所以这是特别困难的。所有的现有技术方法都要求辅助操作或辅助步骤,以取得成功的结果。因此,对反射比读数测定仪的这个方面进行简化是合乎需要的。
红血细胞或其他有色组分的存在往往干扰这些绝对值的测定,因此要求从这两个广泛应用的现有方法中,除去红血细胞。在美国专利第3298789号所述的装置中,所用的乙基纤维素薄膜可以防止红血细胞进入试剂垫。同样地,美国专利第3630957号中所用的抗水薄膜也可以防止红血细胞进入试剂垫。在这两种情况下,冲洗或擦净都起到了测量前除去红血细胞的这些潜在干扰的作用。
因此,仍然需要一种测定有色液体,如血液中的分析物的系统,该系统并不要求从可得到反射读数的反射条中除去过量的液体。
本发明为诊断测定提供了新的方法、组分和装置,其中包括含有信号产生系统的亲水多孔基体和反射比测量仪器,该仪器是当液体渗入基体时在基体的反射比改变的时候起动的。该方法包括将样品(一般为全血)加到基体中,此基体过滤出大颗粒,如红血细胞,通常将基体放在仪器内。信号产生系统产生一种产物,此产物进一步改变基体的反射比,这种改变可与样品中存在分析物相关联。
诊断测定系统的典型例子是全血中葡萄糖的测定,测定是在不受血液干扰而且也没有易受操作误差影响的复杂记录情况下进行的。
结合附图并参考以下的详细说明,很容易理解本发明的内容。附图说明如下:
图1是一个测定装置实施例的透视图,该装置包括可涂被分析液体的反应垫。
图2是实施本发明的仪器的方框示意图。
图3是实施本发明的另一种仪器的方框示意图。
本发明提供一种应用可靠的和容易操作的仪器的改进的快速简易方 法来测定葡萄糖一类的被分析物,尤其是测定可导致产生作为酶产物的过氧化物酶的酶底物。该方法包括将足以使基体饱和的少量全血涂到多孔基体上。与基体结合的是一种或几种试剂的信号产物系统,此种系统产生一种产物,促使基体反射比发生变化。测定血液时,基体通常是放在反射比测量仪器中。液体样品渗透到基体中,可导致在测量表面开始发生反射比的变化。在反射比开始变化以后,然后记录一次或几次读数,将测量表面或基体的反射比的进一步的变化,作为反应产物形成的结果与样品中被分析物的量相关联。
为了测定血液,尤其是测定葡萄糖,一般将全血用作测定介质。基体含有产生过氧化氢的氧化酶。基体中还含有另一种酶,特别是过氧化物酶和染料系统,此染料系统可与过氧化物酶一起产生吸光产物。吸光产物改变反射信号。对全血测定来说,读数是在二个不同的波长记录的,将在一个波长上的读数扣除由血细胞比容、血液氧合作用以及会影响结果的其他可变因素所引起的背景干扰。
所用试剂组分包括基体和含在基体中的信号产生系统的各个组成组分。试剂组分可以包括其他特殊用途的组成部分。本发明方法要求将很少量的血液涂到基体上,血液一般不需要进行预处理(但可任意用抗凝血剂处理)。测量的计时是当液体渗入基体时由自动检测基体反射比的变化的仪器来起动的。然后在预定的时间内,将反射比的变化作为反应产物形成的结果,与样品中被分析物的含量相关联。
本发明所考虑的第一个部分是试剂组分,通常是一种垫的形状,其中包括惰性多孔基体和信号产生系统的组成部分,此信号产生系统浸入多孔基体的微孔中、能与被分析物反应,产生光吸收反应产物。信号产生系统并不明显地阻碍液体通过基体。
为了有助于读取反射比,基体最好至少有一面基本上是平滑的。一般将基体制成薄片状,至少有一面是平滑的。用时将被分析的液体样品 涂到薄片的一面,从而使任何测定化合物都可借助毛细管作用、毛细作用、重力流动作用和(或)扩散作用通过试剂组分。在基体中信号产生系统的各个组成部分可进行反应产生光吸收反应产物。入射光所照射的试剂组分部位不是涂有样品的部位。光由试剂组分表面反射成漫反射光,这种反射光可通过反射分光光度计的检测器来进行会聚和测量,反射光的量可与样品中被分析物的量相关联,通常是与样品中被分析物的量成反函数关系。
形成试剂组分所需的各个组成部分依次介绍如下。第一种组成部分是基体本身。
基体是一种亲水多孔基体,可以共价键或非共价键与反应物键合。合,而对蛋白质生物活性,例如酶的酶活性没有明显的有害作用。对共价键合的蛋白质来说,基体具有共价键合的活性位,或者可用已知方法来进行活化。基体的组合物具有反射性,其厚度足以使其空隙容积内或在其表面上有可能形成吸光染料,而实际上影响从基体发生的反射。基体可以是由均匀的组合物组成,或者涂在底物上,以提供所需的结构和物理特性。
基体通常不会在润湿时变形,因此能保持其原来的构型和大小。基体具有一定的吸收能力,所以在合理的限度内能标定其吸收量,变化范围通常低于50%左右,最好是不高于10%。基体具有充分的润湿强度,完全可以进行常规制作。基体可以使非共价键合的试剂相当均匀地分布在基体的表面上。
基体表面采用聚酰胺是一个典型的例子,尤其是用于全血样品,它通常是由4~8个碳原子的单体缩合而成的缩聚物,其中单体是内酰胺或二胺和二羧酸的化合物。具有相同性质的其他聚合物组分也可采用。可将聚酰胺组分改性后引入其他可提供带电结构的官能团,使基体表面可不带电、带正电或带负电,以及呈中性、碱性或酸性。较好的表面是 带正电的表面。
当用于测定全血时,较好的多孔基体的平均孔径约为0.1~2.0微米,而更好的是约为0.6~1.0微米。
制备多孔材料的优选方法是将亲水聚合物浇注在非织造的纤维芯上,芯纤维可以是能产生所述的完整性和强度的任何纤维材料,例如聚酯和聚酰胺。可形成吸光反应产物的试剂存在于基体的孔中,但并不阻塞基体,所以要分析的测定介质的液体部分,例如血液可流过基体的微孔,而颗粒物质例如红血细胞则保持在基体的表面上。关于试剂形成的吸光反应产物将在后面作详细讨论。
基体实际上是具有反射能力,所以能够不用反射背衬也能产生漫反射。照射在基体上的入射光较好的是至少有25%被反射,更好是至少有50%被反射,而且以漫反射光发射。通常所用的基体厚度小于0.5毫米左右,0.01~0.3毫米左右较好,0.1~0.2毫米最好,尤其对尼龙基体来说更是如此。
虽然并不一定必须将基体附着在载体上,但是为了使基体具有物理形状和刚性,一般还是将基体附着的载体上。图1提供本发明的一个实施例,图中将一块薄的亲水基体垫11用粘合剂13固定在塑料载体12的一端,此粘合剂13将试剂垫直接地和牢固地粘附在把手上。在试剂垫11与塑料载体12粘附的部分上有一孔14,使样品能够涂在试剂垫的一面上,而光则从另一面反射。
将欲测液体样品涂在垫11上。通常,用血作为所测样品的实例,将试剂垫放在表面积约为10平方毫米至100平方毫米的表面上,最好是在10平方毫米至50平方毫米的表面上,通常此试剂垫的容量是5~10微升的样品就可超过使其饱和的容量。
在现有技术中测量漫反射比,通常是将反射背衬粘附在或放在基体后面。实施本发明时,可以不要这种背衬,或通常是把此种背衬作为试 剂组分或反射装置的一个组成部分。
如图1所示,载体支承着试剂垫11,使样品能涂到试剂垫的一侧而光反射比则从涂有样品的试剂垫的反面一侧进行测量。
在图2提供的系统中,试剂被涂在背面手把上带孔的一侧,而光则在试剂垫的另一侧反射并对其进行测量。除了所述结构外,还可采用另一些结构。以本文所提供的范围为条件,试剂垫还可以制成各种形状和形式。此种垫至少要有一面,通常是两面都可以使用的。
可用任何适合的方法将亲水层试剂组分附着在载体上,例如支持器、夹持器或粘结剂,但是较佳方法是将其粘合在衬垫上,这种粘合可以用不起反应的任何粘合剂,和加热法来进行,此法将衬垫表面熔化到足以截留某些用于亲水层的材料,或者应用微波粘合法或超声粘合法,这些方法同样是将亲水样品垫熔化到衬垫上。重要的是这种粘合本身基本上不会干扰漫反射比的测量或所测量的反应,不过,由于在测出读数的部位不需要有粘合剂存在,所以,这种情况不大可能发生。例如,可将粘合剂13涂在衬条12上,随后首先将孔14打在组合在一起的衬条和粘合剂上,然后再将试剂垫11铺在孔14附近的粘合剂上,使试剂垫的外圈部分粘附在衬条上。
任何信号产生系统均可应用,只要此种信号产生系统能与样品中的被分析物反应(直接或间接地)生成一种化合物,此种化合物能在某一波长上而不是在测定介质实际上吸收的波长上具有特性吸收。
聚酰胺基体尤其适用于底物(被分析物)与利用氧的氧化酶按下述方式所进行的反应,即首先产生一种产物,此产物再进一步与染料中间体反应,直接或间接地生成吸收预定波长的染料。例如,一种氧化酶能够将底物氧化并产生作为反应产物的过氧化氢。然后过氧化氢可在催化反应或非催化反应中,与染料中间体或前体反应,生成一种氧化态的中间体或前体。这种氧化过的物质可以生成有色产物或与另一个前体反应, 生成最终染料。
被分析物和典型试剂的例子包括下表所列的物质,但并非仅限于所列举的例子。
被分析物和样品类型    试剂
血液、血清、尿或其他    葡萄糖氧化酶,过氧化物酶和氧受体
生物液体、酒、果汁或    氧受体包括:
其他有色含水液体中的    邻联(二)茴香胺(1)
葡萄糖。全血是特别优    邻甲苯胺
选的样品类型。    邻联甲苯胺(1)
联苯胺(1)
2,2′-连氮基-二(3-乙苯噻唑啉磺酸
-(6))(1)
3-甲基-2-苯噻唑啉酮腙+N,N-二甲基苯
胺(1)
酚+4-氨基非那宗(1)
磺化2,4-二氯苯酚+4-氨基非那宗(2)
3-甲基-2-苯噻唑啉酮腙+3-(二甲氨基)
苯甲酸(3)
2-甲氧基-4-烯丙酚(4)
4-氨基安替比林-二甲基苯胺(5)
(1)根据Richterich和Columbo的报导(Clinical    Chemistry,P.367)及本文引用的参考文献。
(2)Analyst,97,(1972)142~5。
(3)Anal.Biochem.,105,(1980)389~397。
(4)Anal.Biochem.,79,(1977)597~601。
(5)Clinica    Chemica    Acta,75(1977)387~391。
以上皆为本文的参考文献。
本发明的分析方法取决于由漫反射所测得的吸光率的变化,而漫反射决定于所测样品中被分析物的含量。这种变化可通过测量检验样品在经过一定时间的两点或多点之间吸光度的变化来测定。
测定的第一步是将样品涂到基体上。具体的分析步骤如下:首先要取得含有被分析物的含水液体的样品,例如可用扎手指针取得血液。在测定反射比的区域内,将超过基体饱和量的此种液体(即约5~10微升)涂到测试装置的试剂组分上。从下文即可清楚了解到,不需要同时启动计时器(在现有技术中通常需要同时启动计时器)。可除去剩余的液体,例如用薄吸墨水纸,但这种用薄吸墨水纸除去剩余的液体的操作也并不是必须的。测试装置一般装在读取光吸收率的仪器中;例如在涂样品前,通过测量反射比来测定显色强度。在涂样品后的一定时间,测量吸光率。本文所述的吸光率,不仅是指在可见光波长范围内的光,而且还包括可见光波长范围以外的光,例如红外线和紫外线。从这些吸光率的测量中,可根据被分析物的量来标定显色率。
合适的仪器,例如采用带有适当软件的漫反射分光光度计,可以在一定时间自动读取反射比,计算反射比变化率,并用校正系数计算含水液体中被分析物的含量。在图2中示意显示这种装置,图中显示本发明的测试装置,其中包括固定试剂垫11的衬条12。光源5,例如采用高强度发光二极光(LED)将光束投射到试剂垫上。从试剂垫漫反射出光的主要部分(在没有反应产物的条件下,至少为25%较好的是至少35%,更好的是至少为50%),用光检测器6,例如采用光电晶体管,其所产生的输出电流与其所接受的光成正比,来进行检测。在需要时,可将光源5和/或光检测器6进行改装来产生或响应特定波长的光。将光检测器6的输出信号输给放大器7,例如采用将光电晶体管电流转变为电压的线性 集成电路。可将放大器7的输出信号馈给跟踪和保持电路8。这是一种线性/数字组合集成电路,可跟踪或追踪放大器7的模拟电压,在微处理机20发生指令时将电压锁定或保持在当时的水平。模数变换器19从跟踪和保持电路8中得到模拟电压,在微处理机20发出指令时,将其变换为,例如,12位二进制数字码。微处理机20可以是一种数字集成电路。它具有下述各种控制功能:1)为整个系统计时;2)读取模数变换器19的输出信号;3)与程序数据存储器21一起,存储相应于在特定时间内所测得的反射比的数据;4)根据存储的反射比数据计算出被分析物的含量;以及5)将被分析物的浓度数据输送给显示器22。存储器21可以是存储数据和微处理机操作程序的数字集成电路。报表装置22可取各种硬拷贝和软考贝形式,通常它是一种光学显示器,例如液晶显示器或LED显示器,但也可采用纸带打印机、音响信号等显示形式。在需要时,仪器还可包括起停开关并能提供音响或目视报时输出信号,来指示涂布样品和读取数据等的时间。
在本发明中,反射电路本身可通过测量反射比的下降来起动计时,这种反射比下降是在涂在试剂垫上的悬浮液中的含水部分(例如血液)迁移到测量反射比的表面时发生的。一般说来,在测量装置接通“就绪”状态时,在最短的时间间隔内(一般为0.2秒左右),从通常为灰白色的基本干燥的未经反应的试剂条上自动读取反射比数据。测量一般是在被分析的液体渗透到基体之前,但也可在液体被涂到试剂组分上不是测量反射比的部位后开始进行。用微处理机评定反射比值,一般将逐次值存储在存储器中,然后将各个值与未反应的起始值进行比较。当水溶液渗透到试剂基体时,反射比下降发出起动测量时间间隔的信号。反射比下降5~50%时,可用来起动计时,通常下降大约10%时可起动计时。用这种简单的方法,可使测定介质达到进行测量的表面与开始读数顺序完全同步,无需使用者参予活动。
尽管本申请说明书中所述的所有系统特别适宜使用聚酰胺基体,并且还特别适宜于将这类基体用于测定各种糖类,例如葡萄糖以及源于生物的其他物质的浓度,但是并不需要把本发明的反射比的开关限制于这类基体。例如,用任何不溶于水的亲水物质和任何其他种类的反射比测定物都可以形成与反射比开关一起使用的基体。
提供测定红血细胞中葡萄糖的具体例子,目的在于更详细地说明本发明的优点。虽然此实例是本发明的一个优选实施例,但并不能将本发明局限于检测血液中的葡萄糖。
用于组成试剂组分的聚酰胺表面提供了许多本发明所需要的特征。这些特征是试剂组分是亲水的(很易吸收试剂和样品)、不因润湿而变形(因而为读取反射比而提供平滑的表面)、能与酶配伍(为了提供良好的贮存稳定性)、吸收每单位薄膜体积中有限量的样品(为显示扩大的动力学测量范围所必须的)、以及具有足够的润湿强度,因此可以按常规方法来制造。
在典型的结构中,实施本方法可用包括塑料载体和试剂组分(基体具有浸透在其中的信号产生系统)的仪器。用于制备试剂组分的优选基体是尼龙微量过滤膜,尤其是由浇注在非织造聚酯纤维芯上的尼龙66制成的薄膜。许多这类尼龙微量过滤膜是由Pall超微过滤公司生产提供的,平均孔径为0.1~3.0微米。这类材料具有机械强度和柔曲性、在与水接触时的尺寸稳定性、以及快速润湿的性能。
尼龙的具体化学结构可以有许多变化,其中包括未官能化的含有带电端基的尼龙66(由Pall超微过滤公强出售,商标为Ultipose;“Pall”)。正电荷为主的在pH6以下,而负电荷为主的在pH6以上。在其他些一薄膜中,在形成薄膜之前先将尼龙官能化,得到具有不同性质的薄膜。用羧基官能化的尼龙在pH值很宽的范围内带负电荷,(Pall公司以名为Carboxydyne出售)。尼龙还可在其表面上用高密度带正电 荷基团,一般用季胺基团进行官能化,使其在pH值很宽的范围内电荷变化很小(Pall公司出售,产品名为Posidyne)。这种材料特别适用于实施本发明。所用的薄膜还可以具有用于蛋白质共价固定的反应官能团(Pall公司出售,名为Biodyne免疫亲合薄膜)。这种材料可用于共价连接用作试剂的蛋白质,例如酶。虽然所有这些材料都可采用,但在其表面具有高密度带正电荷基团的尼龙,当按配方制成干试剂垫时可提供最好的试剂稳定性。未官能化的尼龙提供仅次于最好的稳定性,羧化尼龙也提供仅次于最好的稳定性。
当与全血一起使用时,能够得到所需结果的孔径约为0.2~2.0微米,较佳约为0.5~1.2微米,最佳约为0.8微米。
有试剂组分在其上面组合的把手的形状是比较不重要的,只要把手能使样品到达试剂组分的一面和使被测量其反射比的入射光到达试剂组分的另一面。把手还有助于把试剂组分放入吸光度测量装置,使它能与光学系统对齐。适合用的把手的一个例子是聚酯薄膜条或其他塑料条,在该条上已涂有转移粘合剂,例如3M    465或Y9460转移粘合剂。在塑料条上冲一个孔,穿过转移粘合剂。然后将含有试剂或以后再加试剂的试剂组分,一般为薄垫形状,用转移粘合剂贴在把手上,使其与穿过把手和转移粘合剂的孔的周围的把手牢固地粘结在一起。这种装置已在图1中说明,图中显示将试剂垫11用粘合剂13与聚酯薄膜把手12粘结。孔14可使样品或入射光到达试剂垫11的一面,到达试剂垫的另一面则是不受限制的。可以选择试剂垫和把手的尺寸,以便使试剂垫在最靠近光源和反射光检测器位置上牢固地装进反射比读数仪器。
如果选择尼龙基体来做试剂垫,当使用所指出的厚度时,最好是将试剂垫用夹持器来承载,承载的方法是从任何方向来测量,在涂有样品的和测量光反射比的部位上没有超过6微米的试剂垫是不被夹持器承载的。没有支承的面积较大,则往往会使薄膜的尺寸稳性较差,从而给测 量表面的反射比带来不利的影响。图1所示试剂条上的孔14的直径为5毫米,其操作情况令人满意。
对此种孔的最小直径并无特别限制,不过,为了使制造、样品涂布和光反射比读取容易进行,较好的孔直径至少是2毫米。
虽然许多染料都能用作指示剂,但其选择仍然决定于样品的性质。对于全血作为测定介质,或在被分析的溶液中有其他测定介质和其他污染物来说,必须选择一种染料,此种染料具有一种吸光率,此吸光率的光的波长不同于红血细胞吸收的光的波长。MBTH-DMAB染料偶合(3-甲基-2-苯噻唑啉酮腙氢氯化物和3-二甲氨基苯甲酸),虽然前面已经介绍过适用于酶免疫测定中过氧化物酶标记物的显色,但从未用于市售的葡萄糖测量试剂中。这种染料偶合产生较大的动力学范围,并且与用于葡萄糖测量的传统染料,例如联苯胺衍生物相比,酶的稳定性提高了。此外,MBTH-DMAB染料偶合并不致癌,而是具有大多数联苯胺衍生物的特征。
能够用于测量葡萄糖的另一个染料偶合是AAP-CTA(4-氨基安替比林和铬变酸)偶合。虽然此染料偶合的动力学范围不如MBTH-DMAB的宽,但在测量葡萄糖时却是稳定的,适用于实施本发明。再者,AAP=CTA染料偶合的动力学范围扩大了,其酶催化活性稳定性大于较广泛使用的联苯胺染料。
使用MBTH-DMAB偶合可以用一个校准系数来校准血细胞比容和血液氧合程度。较为普遍使用的联苯胺染料并不能作这样的校准。此染料形成的发色团,能吸收大约635毫微米的波长,但不能有效地扩展到700毫微米。在测量波长时容许的变动辐度很小(约±10毫微米)。在700毫微米波长处,可以通过测量血液颜色来测量血细胞比容和氧合程度。此外,市售发光二极管(LED)可在635毫微米和700毫微米两个波长处进行测量,从而简化了测量装置的大批生产。采用上述最佳的薄膜孔径和本试剂配方,就可在700毫微米一个波长上进行测量来校准血细胞比 容和氧合性能。
发现有两个附加条件可对聚酰胺基体上的葡萄糖氧化酶和过氧化物酶的配方提供特殊的稳定性和较长的储存期限。这二个附加条件是应用在3.8~5.0,较好的是大约3.8~4.3,最好的是大约4.0的pH值范围,和使用高浓度的缓冲系统来将试剂涂在基体上。最有效的缓冲液为10%(重量)的柠檬酸缓冲液,有效浓度为5~15%。在使用这种重量/体积百分比的溶液中,可将试剂涂在基体上。同样摩尔数的其他缓冲液也可使用。采用低pH值,最好pH4左右、MBTH-DMAB染料系统、以及大约500~1000单位/毫升的高浓度酶溶液,可以获得最大的稳定度。
在制备MBTH-DMAB试剂和形成信号产生系统的其余部分的酶系统时,不需要保持精确的体积和比值,不过,应用下面建议的数值可得到良好的结果。当满足下述条件时,试剂很易被基体吸收,这些条件是:葡萄糖氧化酶在溶液中有大约27~54%(体积),过氧化物酶的浓度约为2.7~5.4毫克/毫升,MBTH的浓度约为4-8毫克/毫升以及DMAB的浓度约为8~16毫克/毫升。DMAB-MBTH的重量比较好的是保持在(1-4)∶1,更好的是在大约(1.5~2.5)∶1,最好的是在大约2∶1。
试剂组分的基本制作技术一旦建立后是很简单的。薄膜本身是牢固和稳定的,选用优选实施例中的尼龙薄膜尤其如此。涂试剂只需要二种溶液,而这二种溶液都很容易配制,并且很稳定。第一种溶液通常含有染料成分,第二个溶液通常含有酶。例如当使用MBTH-DMAB染料偶合时,将各个染料溶于含水有机溶剂,一般使用1∶1的乙腈和水的混合物。将基体放在溶液中浸一下,吸去多余的液体,然后将基体在50~60℃下干燥10~20分钟。再将含有染料的基体浸在含酶的水溶液中。典型的配方中含有过氧化物酶和葡萄糖氧化酶,以及任何所需的缓冲液,防腐剂、稳定剂等。然后将基体吸干,除去多余的液体并按上述条件进行干燥。葡萄糖试剂的典型配方如下:
染料浸渍
组合:
40毫克MBTH,
80毫克DMAB,
5毫升乙腈,
5毫升水。
搅拌至所有固体全部溶解后,倾注在玻璃板或其他平滑表面上。浸渍一片Posidyne薄膜(Pall公司产品),吸去多余液体,在56℃下干燥15分钟。
酶液浸渍
组合:
6毫升水,
10毫克EDTA二钠盐,
200毫克缩多氨酸,低粘度,<Sigma′
0.668克柠檬酸钠,
0.523克柠檬酸,
2.0毫升6%(重量)Gantrez    AN-139溶于水中,<GAF′
30毫克辣根过氧化物酶,100单位/毫克,
3.0毫升葡萄糖氧化酶,2000单位/毫升。
搅拌至所有固体全都溶解后,倾注在玻璃板上或其他平滑表面上。浸渍一片预先用染料浸透过的薄膜,吸去多余的液体,在56℃下干燥15分钟。
用于读取反射比电子仪器至少包括光源、反射光检测器、放大器、模数变换器、带存储器和程序的微处理机和显示装置。
光源一般由发光二极管(LED)组成。虽然可以采用多色光源和能测量两个不同波长的光检测器,但是优选的仪器则包括两个LED光源或一 个能发射两个不同波长的光的二极管。能产生本说明书中所述的波长的光的市售LED,包括Hewlett    Packard    HLMP-1340,发射的最大波长为635毫微米,和Hewlett    Packard    QEMT-1045,窄带发射的最大波长为700毫微米。适用的市售光检测器包括Hammamatsu    5874-18K和Litronix    BPK-65。
虽然其他测量方法都可采用,但下述方法可提供合乎需要的结果。在开始计时后,在特定的时间间隔,用光电检测器进行读数。635毫微米LED仅在很短的测量时间间隔期间开动,该测量时间间隔是在发射比开关所显示的起动时间后大约20秒钟开始的。如果这个读数显示,在样品中葡萄糖含量很高,为了提高精度,可取30秒读数并将其用于最后计算中。一般认为,高含量的起点约为250毫克/分升。用测量开始后大约15秒钟所取的700毫微米的读数来校准背景。当适用的LED被启动时(一般不到1秒钟),将光检测器在时间间隔内得到的读数进行积累。将信号放大并转换成数字信号后,然后将得到的反射比原始读数用微处理来进行计算。各种微处理机都可用于计算。Rockwell国际公司制造的AIM    65单板微计算机已证明是令人满意的。
对于使用者来说,本发明的方法和仪器,程序非常简单,操作步骤最少。使用时,将试剂条放在检测器中,条中的孔与检测系统中光学器件对齐,将可移动的盖子或其他罩子放在光学器件和试剂条上,保护装置使其不受环境光的影响。然后按测量仪器上的键钮,开始测量顺序,启动微计算机,测量从未反应的试剂垫上反射出的光,即所谓的空白读数(R)。移去盖子,将一滴血涂在试剂垫上,一般是在试剂垫与光学器件和读数装置对齐时才将血涂在试剂垫上。为了减少操作步骤,较好的是将放在检测器中的试剂条与光学器件对齐。当样品流过基体和在其反面侧量反射光时,由于反射比的降低,仪器能够检测出血液或其他样品的涂布情况。反射比的降低启动计时顺序,并于这个问题将在本说明书 的其他部分予以详细介绍。在涂样品的15秒钟内,应再将盖子盖上,不过这段时间的长短取决于所测样品的种类。当测量血糖样品时,一般是在涂血液后约30秒即可显示结果,不过对于葡萄糖浓度低于250毫米/分升的葡萄糖样品来说,20秒钟的反应时间也是容许的。假如测定其他样品时,显示结果的适宜时间可以有所不同,而且根据所选择的试剂/样品的特性很容易测定出来。
应用本底电流,即,从带电但无光从试剂垫上反射的光电检测器发出的电流(以便对本底进行校正),可以对葡萄糖含量(或任何其他被测定的分析物)进行特别准确的评估。业已证明,根据本说明书的优选实施例制作的特殊仪器,在2~3个月内,此数值是不会变化的,而且有可能把该背景读数作为常数编存到计算机存储器中。但是,对于每一次的分析来说,为了取得较精确的结果,将此步骤稍加改进,即可测出此数值。在此改进的步骤中,在将试剂条放入之前可先将测量仪打开,盖上盖了,即可测出本底电流。然后再将测试条放入测量仪中,盖上盖子,测定R值,然后再按上述方法继续进行操作。对于这种改进方法来说,在测量仪的整个使用期内,不需要稳定的本底电流也可以提供较精确的结果。
计算葡萄糖测定结果所需的原始数据是上述以本底反射比(Rb)记录的本底电流;还有上述的未反应的测试条的读数(R);以及终点测定值。应用本文中所述优选实施例,终点并不特别稳定,并且必须从开始涂布血液起精确计时。但是,本文中所述的测量仪可以自动进行这种计时。对于葡萄糖浓度低于250毫克/分升时,在20秒内可达到适宜的稳定终点,并读取最终反射比R20。对于葡萄糖浓度高达450毫克/分升时,读取30秒的反射比读数R30是合适的。虽然本文中所述的系统,具有高达800毫克/分钟葡萄糖的良好辨别能力,但是有一定程度的干扰而且葡萄糖浓度高于450毫克/分升时结果就不准确了,不过,还不致于大到 发生严重问题。对于较高水平的葡萄糖浓度来说,较长的反应时间应可提供更为合适的读数。
对于双波长测量来说,700毫微米反射比读数通常是在15秒时读取(R15)。在15秒钟时,血液将使试剂垫完全饱和。超过15秒钟,染料反应继续进行,并可检测到一小部分700毫微米的读数。由于染料吸收700毫微米的信号是不利的,所以在计算时可以不考虑超过15秒以上的读数。
上述原始数据可用于计算正比于葡萄糖浓度的参数,葡萄糖浓度比反射比测量更容易目测。在需要时,可应用反射比的对数变换,这种变换类似于在透射分光光度计中观察到的吸收率与被分析物浓度之间的关系(比尔定律)。特别为反射比分光光度计推导的简化的Kubelk-Monk方程已证明是特别有用的。在此推导式中,将K/S与被分析物的浓度相关联,K/S的定义可用下列方程式1描述。
K/S-t=(1-Rt)/(2×Rt) (1)
Rt是在一特定终点时间t时所取的反射比,并且是式(2)所述的入射光束的被吸收部分,在式(2)中,Rt是终点反射比R20或R30
Rt=(Rt-Rb)/(R-Rb) (2)
Rt的变化范围是从无反射光(Rb)时为0至全反射光(R)时为1。在计算时应用反射率,大大简化了测量仪的设计,因为高稳定的光源和检测电路都不需要了,由于这些组件是由每个R和Rb的测量值来监控的。
对一个波长的读数来说,K/S可在20秒(K/S-20)或30秒(K/S-30)时进行计算。将YSI(耶洛斯普林斯仪器公司Yellow    Springs    Instruments)葡萄糖测定值与这些参数联系起来的校准曲线,可用方程式(3)概括的三阶多项式方程来精确地描述。
YSI=a0+a1(K/S)+a2(K/S)2+a3(K/S)3(3)
这些多项式的系数列于表1。
表1
单个波长校准曲线的三阶多项拟合系数
K/S-20    K/S-30
a0-55.75 -55.25
a10.1632 0.1334
a2-5.765×10-5-2.241×10-5
a32.58×10-81.20×10-8
在优选实施例中所测定的单个化学物质是MBTH-DMAB吲达染料,被分析的复合基体是分布在0.8微米Posidyne薄膜上的全血。题为“近红外分光光度测量方法在食品非破坏性分析中的应用:实验结果综述”(CRC Critical Review in Food Science and Nutrition,18(3)203~30(1983))的综述,介绍了测量光密度差△OD(λab)的仪器的应用,其中ODλa是相当于所测成分的吸收峰值的波长的光密度,ODλb是相同成分无明显吸收的波长的光密度。
双波长测量的计算方法必然比单波长测量的复杂,但却更有效。用700毫微米读数进行的第一次校正,是简单地扣除血液的背景颜色。为了进行这种校正,由于血液颜色造成的在635毫微米和700毫微米之间吸光率的关系可以并且已经通过在很宽的血液颜色范围内测量含有0毫克/分升葡萄糖的血液样品来进行测定。颜色范围是由改变血细胞比容来建立的,并观察到是相当好的线性关系。根据这些曲线,可将在700毫微米处的K/S-15进行正规化,得到相当于在635毫微米处的K/S-30。在方程式(4)中叙述了此种关系,式中K/S-15n是在700毫微米的正规化的K/S-15。
K/S-15n=(K/S-15×1.54)-0.133    (4)
必须注意的是正规化的700微毫米信号和635毫微米信号只是在葡萄糖为0对才会相等。导出校准曲线的表示式的定义可用下列方程式5和6描述。
K/S-20/15=(K/S-20)-(K/S-15n)    (5)
K/S-30/15=(K/S-30)-(K/S-15n)    (6)
这些曲线是用类似于方程式(3)的四阶多项式方程的最好拟合,即将四阶项K/S加到式(3)中去。上述方程的计算机拟合系数列于表2。
表2
双波长校准曲线的四阶多项式拟合系数
K/S-20/15    K/S-30/15
a0-0.1388 1.099
a10.1064 0.05235
a26.259×10-51.229×10-4
a3-6.12×10-8-5.83×10-8
a43.21×10-111.30×10-11
还研究出应用第二次校正来消除色谱法影响造成的误差。低血细胞比容样品与具有相同的635毫微米读数的高血细胞比容样品相比,其特征在于具有低的700毫微米读数。当(K/S-30)/(K/S-15)比在宽的血细胞比容和葡萄糖浓度的范围内对K/S-30作图时,在图上形成的曲线表明显示色谱法影响(在曲线以上)和没有色谱法影响(在曲线以下)的样品之间的界线。曲线以上的样品的K/S-30通过将读数提高到对应于在具有相同(K/S-30)/(K/S-15)的曲线上的某个点来进行校正。
上述校正因子是专用于单架仪器和有限数量的试剂的制剂。对于各个仪器和试剂的最佳计算方法可按上述相同方法。
总之,本发明的系统将操作者的操作步骤减少到最少的程度,比现有技术的反射比读数方法具有更多的优点。例如,在与现有的测定血液 中葡萄糖的方法相比,具有许多明显的优点。第一,使薄试剂垫饱和所需要的样品量很少(一般为5~10微升)。第二,所需操作时间仅仅是将样品涂到薄亲水层上和盖紧盖子所需的时间(一般为4~7秒钟)。第三,不需要同时开始计时。第四,可用全血。本发明方法不需要进行分离或利用无红细胞样品,而且还可以应用于其他深色样品。
由于应用全血实施本发明还导致一些不明显的优点。一般说来,含水溶液(如血液)会渗入亲水薄膜,而在薄膜背面形成一层液体层,于是此种表面不适合于进行反射比的测定。但是已经发现,显然由于血液中的红血细胞和蛋白质与基体发生作用,血液就会润湿聚酰胺基体而无多余的液体渗入多孔基体,来在基体背面干扰反射比读数。
此外,用于本发明的薄膜在润湿时,会被认为是能透射光的,而只有一部分微弱信号返回反射比测量装置。现有技术一般都指出,为了反射足够的光,反射层必须在基体后面。在其他的情况下,在测量颜色前,将白色垫放在试剂垫的后面。但是在本发明的情况下,既不需要反射层,也不需要白色垫。事实上,本发明一般是当入射光照射到基体时,在试剂组分的背面放一块吸光表面来进行的。应用在试剂组分背面有一块的吸光表面,并同时在两个不同波长上测量反射比,就可以得到满意的反射比测量结果,而无需从基体中除去多余的液体,从而减少了现有技术一般要求的步骤。
以上对本发明作了一般性介绍,参阅下述具体实施例,将会更好地理解本发明,除非另有说明,否则这些实施例只是为了说明本发明,而不能认为是用来限制本发明。
实施例1
重现性:
应用一份男性的血液样品(JG,血细胞比容=45),收集列于表3~5的重现性数据。
表3
单波长MPX系统的重现性
平均值(毫克/分升)    S.D.(毫克/分升)    %C.V.
YSI(毫克/分升)    20秒    30秒    20秒    30秒    20秒    30秒
25    23.1    23.0    2.1    2.04    9.1    9.0
55    53.3    53.2    3.19    3.32    6.0    6.3
101    101    101    3.0    3.3    3.0    3.3
326    326.6    327    13.3    9.8    4.1    3.0
501    503    17.1    3.4
690    675    28    4.15
810    813    37    4.5
表4
双波长MPX系统的重现性
平均值(毫克/分升)    S.D.(毫克/分升)    %C.V.
YSI(毫克/分升)    20秒    30秒    20秒    30秒    20秒    30秒
25    25    27    1.34    1.55    5.4    5.7
55    55    57.4    2.58    2.62    4.7    4.6
101    101    101.5    2.55    2.18    2.5    2.1
326    332    330    15.0    7.1    4.5    2.1
501    505    21.3    4.2
690    687    22.8    3.3
810    817    30.4    3.7
表5
3.0毫米直径孔隙的重现性
%C.V.
YSI(毫克/分升)    4.7毫米    3.0毫米
55-100    4.8    4.9
300    3.0    5.0
600    3.8    5.5
平均值    3.9    5.1
将血液分成等分试样,加入葡萄糖使其含量范围为25~800毫克/分升。从500个样品条(Lot    FJ4-49B)中随便取样,测定每一条中的葡萄糖检验水平,共进行了20个样品的测定。从本研究的结果得出如下结论:
1)单波长与双波长的比较:30秒双波长的结果的平均C.V.为3.7%V.S.,30秒单波长的结果的平均C.V.为4.8%,在25~810毫克/分升的葡萄糖范围内,平均C.V.值改进了23%。在25~326毫克/分升的葡萄糖范围内,平均C.V.值改进了33%,此时平均C.V.值从5.4%降至3.6%,在最常用的葡萄糖范围内有显著的改进。在25~325毫克/分升的葡萄糖范围内,与单波长的测量相比,20秒的双波长的测量,平均C.V.值的改进量是相同的(表3和表4)。
2)双波长,20秒与30秒结果的比较:在25~100%毫克/分升范围内,20秒结果的平均C.V.与30秒读数几乎相等,即4.2%与4.1%。但是,在326毫克/分升,30秒读数的C.V.为2.1%,而20秒的C.V.为4.5%。正如从K/S-20响应曲线看到的,曲线的斜率在250毫克/公升以上时明显下降。结果异致20秒结果的葡萄糖水平高于300,再现性很差。根据此再现性数据,20秒结果的截止点,大约是在100~326毫克/分升之间。250毫克/分升的截止点可根据下面实施例2中的分离研究结 果进行确定。
3)孔径大小:研究了较小的光学部件孔径,即3.0毫米(如上所述)5~0分钟。应用10个同样的,手工浸渍的片状样品的初始实验,的确证明用3.0毫米的孔径改进了C.V.值,显然是因为较容易与系统的光学部件对齐的缘故。但是,采用机器压制的筒形薄膜时,4.7毫米较大孔径的平均C.V.(表5)为3.9%以(如上所述),3.0毫米孔径的平均C.V.为5.1%。此时C.V.增加了30%,正如下面所讨论的,这很可能是由于机压筒形薄膜的表面不均匀所造成的。
实施例2
分离:
为了将本发明方法(MPX)与一般的现有方法进行比较,采用由耶洛斯普林斯仪器公司(YSI耶洛斯普林斯,俄亥俄)制造的耶洛斯普林斯23A型葡萄糖分析仪,测定36名输血者的血液。输血者男女人数相等其血细胞比容范围为3.5%至55%。所用血样是在30小时内收集的,用肝素锂(lithium    heparin)作为抗凝血剂。每份血液样品分成等分部分,加入葡萄糖,得到152份0~700毫克/分升葡萄糖范围的样品。每份样品都测定两份,得到的数据点总共为304个。
根据这些数据和葡萄糖含量绘制响应曲线,然后用适当的方程式进行计算(表1和2)。然后将这些MPX葡萄糖值对YSI值进行作图,得到点状图。
MPX系统的对比:对20秒和30秒两种测量时间来说,目视观察发现,在单波长的点状图上的点比双波长的点状图上的点更为分散。超过250毫克/分升的20秒读数显得非常分散,但是30秒读数在葡萄糖水平为≥500毫克/分升时才分散得很宽。
在不同的葡萄糖范围内,测定偏离YSI的偏差,用数量来说明这些点状图。得到的结果如下:
表6
根据分离数据确定MPX的精度
MPX    测量时间    S.D(毫克/分升)    C.V.范围*
波长    (秒)    0~50    50~250    250~450    450~70
单    20    ±5.6    7.2    14.5    -
单    30    ±6.9    7.1    8.8    10.2
双    20    ±2.3    5.3    12.8    -
双    30    ±2.19    5.5    5.8    8.4
注:这些是测定方法中的中间C.V.值。
a)双波长系统得到的C.V.值低于单波长系统30%。
b)单波长系统,在0~50毫克/分升范围内,S.D.为±6~7毫克/分升,而双波长的测量,S.D.只有±2.2毫克/分升。
c)30秒MPX测量的截止点为250毫克分升。对50~250毫克/分升来说,20秒和30秒测量可得到相同的测定方法中的中间C.V.值(单波长的约为7%,双波长的约为5.5%)。但是,在250~450克/分升范围时,测定方法中的中间C.V.值则比上述C.V.值高一倍还多,对20秒读数来说,单波长的是14.5%,双波长的是12.8%。
d)30秒读数,在450毫克/分升以上,对单波长和双波长都不适用(C.V.为10.2%和8.4%)。
结论:MPX两个系统的最佳量在0~450毫克/分升范围内。
1)MPX    30双波长系统:此种两个波长系统可提供30稍测量时间,在50~450毫克/分升范围内(表7),C.V.为11.3%,具有95%置信界限(定义是测量概率在YSI的2    S.D.内)和在0~50毫克/分升范围内,S.D.为±4.4毫克/分升。
2)MPX    30/20双波长系统:此种双波长系统可提供20秒测量时间和 在0~250毫克/分升范围内,以及30秒测量时间和在250~450毫克/分升范围内。其95%置信界限与MPX    30双波长系统(表7)的几乎相同,在50~450毫克/分升范围内,C.V.为11.1%,而在0~50毫克/分升范围内,C.D.为±4.6毫克/分升。
表7
MPX、GlucoScan    Plus和Accu-Chek    bG*
试剂条95%置信界限的对比
测量范围    MPX单波长    MPX双波长
毫克/分升    20秒    30秒    20秒    30秒
0~50    11.2毫克/分升  13.8毫克/公升  4.6毫克/分升  4.4毫克/分升
50~250    14.4%    14.2%    10.6%    11.0%
250~450    -    17.6%    -    11.6%
77~405    GlucoScan    Plus(Drexler    Clinical)    15.9%
77~405    Accu-Chek    bG    (Drexler    Clinical)    10.7%
50~450    MPX    20/30    双波长混合    11.1%
50~450    MPX    30    双波长    11.3%
*MPX的置信界限根据YSI得到。GlucoScan    Plus和Accu-Chek    b    G的置信界限由回归方程对YSI作图导出,由于校准时差值较小,故除去偏倚。
实施例3
稳定性
最佳稳定性的大部分实验室小型装置工作都是用人工浸渍的0.8微米Posidyne膜片完成的。具体的染料/酶的配制如前所述。
1)室温稳定性:此研究试图用图来说明响应贮藏在18~20℃用硅胶干燥的0.8微米Posidyne薄膜试剂的任何变化。两个半月后,将室温样品的响应与储存在5℃的样品的响应进行比较时,并无值得注意的变化。 各个点状图的葡萄糖含量范围均为0~450毫克/分升。
2)37℃时的稳定性:37℃稳定性研究所用的试剂与室温研究所用试剂相同。把在37℃下与在室温下,用粘合剂或不用粘合剂加应力的试剂条的葡萄糖含量的差值对时间作图。虽然,由于手制试剂条再现性很差,所以数据是离散的,但是无论是否用粘合剂加应力的试剂条的,稳定性都是极好的。
3)56℃时的稳定性:应用在膜片上的相同配方的不同制剂进行8次5至6天的稳定性研究(表8)。对低葡萄糖(80~100毫克/分升)试验水平来说,在加应力时,平均葡萄糖值下降3.4%,最高下降9.55%。对于高葡萄糖(280~320毫克/分升)试验水平的来说,葡萄糖读数平均下降3.4%,最大下降10.0%。
表8
pH=4.0、0.8微米Posidyne膜片试剂配方在
56℃加应力5~6天的稳定性
百分差(56℃与室温样品比较)
样品编号    YSI(80~100毫克/分升)    YSI(280~320毫克/分升)
FJ22B    -6.25    +5.4
FJ27A    -4.0    -5.14
FJ28B    -2.4    -5.3
FJ30H    -9.55    -10.0
FJ31C    +4.43    -1.24
FJ36    -3.2    -8.5
FJ48B*    -3.0    0.0
GM48A*    -3.0    -2.5
平均值    -3.4    -3.4
*这两个样品含有二倍标准浓度的酶和染料。
研究在56℃加应力19天的薄膜,证明用或不用粘合剂加应力试剂的条没有很大差别。在二种葡萄糖值的情况下,在低检验水平(80~100)和300毫克/分升时,19天的葡萄糖值都下降<15%。
另一项56℃的研究是采用人工浸渍的0.8微米Posidyne薄膜和二倍标准浓度的酶和染料来进行的。制作相同配方的不同制剂,测定14天的稳定性。将两项研究的平均结果绘制成图。高检验水平和低检验水平的葡萄糖在14天内的变化都在±10%以内。这些数据表明此配方特别稳定。
实施例4
样品量
表9列出MPX所需的样品量。
表9
样品量对MPX测定的影响
样品量    双波长    单波长
(微升)    平均值    平均值
低葡萄糖YSI=56
3    41    50    39    31    40    31    42    30    19    30
4    44    49    49    49    48    41    45    44    45    44
5    54    48    49    51    50    50    49    48    49    49
10    48    48    50    47    48    54    53    56    55    54
20    49    49    49    50    49    55    57    58    60    58
高葡萄糖YSI=360
3    301    260    276    286    280    274    232    244    260    252
4    383    387    367    341    367    361    356    342    318    344
5    398    402    382    370    388    378    387    366    351    370
10    364    362    378    368    368    356    358    379    369    366
20    375    370    380    378    376    380    382    389    385    384
用微量移液管将表中所示的样品体积转移到图1所示的试剂垫上。当将扎手指取得的血涂在试剂条上时,不能将全部样品转移,因此,上表所示的体积不代表进行分析时从手指上挤出的所需全部血样量。3-微升的样品是完全覆盖试剂垫圈所需的最低量。此量不能提供足够的样品来完全浸透试剂垫,并且MPX的测定结果偏低。4-微升样品仅仅浸透试剂垫,而5微升样品具显然是足够的。10微升样品是较大的滴量,而20微升样品是极大的滴量,很可能只是在用移液管来取血样时才使用。
在低葡萄糖浓度时,单波长的结果与样品量有一定的关系,而采用双波长测定时,则完全消除了这种依赖关系。虽然单波长的这种关系也许是可接受的,但是,显然是不理想的。
实施例5
再现性:
上述实验测定法总是重复进行的,通常每个数据点测定2、3或4次。即使用极高血细胞比容或极高氧气水平的样品这些结果总是很一致的。C.V.值低于5%。因此,显然,再现性是非常好至极好的。
本发明可提供许多比目前市售的或文献中所介绍的系统好的优点。原始记录简易,几乎不需要专门的技巧,使用者比较地不容易出错。可迅速地进行测定,并使用便宜和比较无害的试剂,是在家中使用的设备和物质的重要条件。使用者得到的结果是可以相信的并可与保养疗法结合起来。此外,试剂具有较长的贮存期限,因此,得到的结果在较长的时期内是可靠的。设备简单可靠,基本自动化。
在本说明书中特别提到的所有专利和刊物,对本专业的普通技术人员来说是列举性质的,而对于与本发明有关系的那些专利和刊物来说,就象那些特别和个别地进行参考的参考文献一样都进行了个别地参考。
现已对本发明作了充分的描述,显然,对本业业的普通技术人员来说,可在不脱离下面权利要求书中所限定的本发明的精神和范围内进行各种修改和改进。

Claims (27)

1、一种采用薄膜和产生光吸收染料产物的信号产生系统测定血样中葡萄糖的方法,该系统与薄膜结合,通过薄膜表面反射比的测量,测定其中染料产物的含量,此法包括将全血涂在薄膜表面上,以及在涂有样品的薄膜表面的另一面进行测量。
2、根据权利要求1的方法,其中包括有信号产生系统的亲水多孔基体和反射比测量仪器,该仪器是当液体渗入基体时的反射比改变的时候启动的,该信号产生系统产生一种染料产物,此种染料产物吸收的光的波长不同于红血细胞吸收的光的波长,反射比测量是在两个不同波长上进行的,其中一个是红血细胞的吸收波长,另一个是染料产物的吸收波长。
3、根据权利要求2的方法,其中两个波长分别约为635和700毫微米。
4、根据权利要求1的方法,其中信号产生系统包括葡萄糖氧化酶、过氧化物酶和3-甲基-2-苯噻唑啉酮腙氢氯化物和3-二甲氨基苯甲酸指示剂(MBTH-DMAB指示剂)。
5、根据权利要求1的方法,其中薄膜的表面是聚酰胺。
6、根据权利要求5的方法,其中聚酰胺带正电荷,而葡萄糖氧化酶、过氧化物酶和3-甲基-2-苯噻唑啉酮腙氢氯化物和3-二甲氨基苯甲酸指示剂(MBTH-DMAB指示剂)则在用于本方法之前先与薄膜结合。
7、一种测定葡萄糖的方法,此法包括将全血样品涂于试剂组分上,其中试剂组分包括可与能够生成反应产物的葡萄糖氧化酶、过氧化物酶和染料指示剂结合的亲水薄膜;使样品渗入该薄膜;通过检测样品渗入薄膜和反射比的降低启动预定时间的反射比读数的计时;通过由染料产物的吸光率产生的反射比的附加变化,测定样品中葡萄糖的含量。
8、根据权利要求7的方法,其中染料指示剂是3-甲基-2-苯噻唑啉酮腙氢氧化物和3-二甲氨基苯甲酸指示剂(MBTH-DMAB指示剂)。
9、根据权利要求7的方法,其中亲水薄膜具有聚酰胺表面。
10、根据权利要求7的方法,其中亲水薄膜带正电荷。
11、一种测定液体中被分析物的测量装置,其中包括装有不透光隔板的容器,该隔板可移动地来装能容纳被分析的吸收液体的多孔基体;照射基体表面的装置;检测从基体反射的两个不同波长的光的光检测装置;收集反射光的读数,以及根据被分析物的读数或反应产物对反射光的第一种波长的吸光率读数和背景对反射光的第二种波长的吸光率读数,计算液体中被分析物含量数值的控制装置;以及报告该数值的装置。
12、根据权利要求11的装置,进一步包括一个在工作时与照光装置、检测装置、控制装置和报表装置相连接的电子动力供应装置。
13、根据权利要求11的装置,其中照光装置和检测两个不同波长的光的光检测装置一起构成两个不同波长的光源和单光检测器,或一起构成一个多色光源和两个只限于检测不同波长的光的光检测器。
14、根据权利要求11的装置,其中第一种波长的光为690~710毫微米,第二种波长的光为625~645毫微米。
15、根据权利要求11的装置,其中控制装置根据二种波长的光中的任何一种波长的光的反射比开始下降时,使计时电路开始启动,反射比的降低是在将液体涂在照明装置所照的基体表面的背面后当液体渗入基体时发生的。
16、根据权利要求11的装置,其中,在反射比开始降低之后,控制装置使一个或几个反射光的读数可在预定的时间间隔内取得。
17、根据权利要求11的装置,其中,控制装置能够在将液体涂到试剂垫之前,收集和储存试剂垫的反射比读数。
18、根据权利要求17的装置,其中,控制装置还能够在无光从试剂垫上反射的情况下收集和储存检测器的本底电流读数。
19、根据权利要求11的装置,其中,当向控制装置提供动力进行分析物检测时,控制装置自动收集和比较检测器的连续反射比读数、当检测到反射比下降时启动计时电路、在反射比下降后在预定的时间间隔内收集反应反射比读数、根据反应反射比读数计算在被分析的液体中分析物的浓度值、并将该值输送到报表装置。
20、按权利要求19的装置,其中当向控制装置提供动力,在进行分析物检测之前,进行基本反射比测量时,在将液体涂到基体之前,控制装置收集和储存基体的基本反射比读数;以及其中当接着向控制装置提供动力进行分析物检测时,则在通过控制装置计算出反射比值之前,通过控制装置,从反应反射比读数中减去基本反射比读数。
21、一种测定液体中分析物浓度的方法,其中,包括在将液体涂到试剂组分之前,定量测定试剂组分第一表面的基本反射比,此试剂组分包括一种惰性多孔基体和一能够与分析物起反应产生吸光的反应产物的试剂系统,此试剂系统是浸入基体的孔隙中;在将液体涂到试剂组分的第二表面,而不是涂在测量反应反射比的第一表面后并在液体已从第二表面通过试剂组分迁移到第一表面后,从试剂组分第一表面定量测量试剂组分的反应反射比;在涂液体后,应用波长不同于测量反应反射比所用的波长的光,定量地测量试剂组分的第一表面的干扰反射比;根据反射比的测量值,计算表示浓度的数值。
22、根据权利要求21的方法,其中基体具有用聚酰胺形成的表面。
23、根据权利要求21的方法,其中基体中的平均孔径为0.2至1.0毫米,而液体是全血。
24、根据权利要求21的方法,其中,当试剂与葡萄糖反应时,产生一种吸光反应产物。
25、一种仪器,它具有使权利要求1至9和21至24中任何一项权利要求的方法的各步骤进行的装置。
26、根据权利要求1的方法,此法是在体外进行的。
27、根据权利要求21的方法,此法是在体外进行的。
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Families Citing this family (701)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215670A (en) * 1978-06-30 1980-08-05 Sunergy Corporation Cooking grate
US4935346A (en) * 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
WO1988009824A1 (en) * 1987-06-05 1988-12-15 National Diagnostic Products (Australia) Pty. Limi Improvements in diagnostic test strips
AU626794B2 (en) * 1987-06-05 1992-08-13 National Diagnostic Products (Australia) Pty. Limited Improvements in diagnostic test strips
US5128015A (en) * 1988-03-15 1992-07-07 Tall Oak Ventures Method and apparatus for amperometric diagnostic analysis
US6270890B1 (en) 1988-03-29 2001-08-07 Colgate-Palmolive Company Dental floss
AU3375789A (en) * 1988-04-28 1989-11-02 Lifescan, Inc. Determination of glucose in whole blood
US4994238A (en) * 1988-06-09 1991-02-19 Daffern George M Constant volume chemical analysis test device
DE3826057A1 (de) * 1988-07-30 1990-02-01 Boehringer Mannheim Gmbh Testtraeger zur analytischen bestimmung eines bestandteils einer fluessigen probe
US5304467A (en) * 1988-11-30 1994-04-19 Kyoto Daiichi Kagaku Co., Ltd. Device for assay of liquid sample
DE68921557T2 (de) * 1988-11-30 1995-07-06 Kyoto Daiichi Kagaku Kk Vorrichtung zum Testen einer Flüssigkeitsprobe.
DE3844104A1 (de) * 1988-12-28 1990-07-05 Boehringer Mannheim Gmbh Testtraeger-analysesystem
DE3911539A1 (de) * 1989-04-08 1990-10-11 Boehringer Mannheim Gmbh Testtraeger-analysesystem
DE3922495A1 (de) * 1989-07-08 1991-01-17 Miles Inc Analyseverfahren fuer substanzen aus biologischen fluessigkeiten, insbesondere vollblut
US6395227B1 (en) 1989-08-28 2002-05-28 Lifescan, Inc. Test strip for measuring analyte concentration over a broad range of sample volume
US5306623A (en) * 1989-08-28 1994-04-26 Lifescan, Inc. Visual blood glucose concentration test strip
JPH0395435A (ja) * 1989-09-08 1991-04-19 Terumo Corp 測定装置
DE3940010A1 (de) * 1989-12-02 1991-06-06 Boehringer Mannheim Gmbh Verwendung eines schwer loeslichen salzes einer heteropolysaeure zur bestimmung eines analyts, entsprechendes bestimmungsverfahren sowie hierfuer geeignetes mittel
DE4015157A1 (de) * 1990-05-11 1991-11-14 Miles Inc Asymetrische sandwich-membranen fuer diagnose-teststreifen
US5209231A (en) * 1990-11-02 1993-05-11 University Of Connecticut Optical glucose sensor apparatus and method
JPH04188065A (ja) * 1990-11-21 1992-07-06 Kyoto Daiichi Kagaku:Kk 液体試料分析用具および分析方法
US5174963A (en) * 1991-01-07 1992-12-29 United Medical Manufacturing Company Blood glucose reflectance meter including a null prompting means and a device for providing a constant brightness light
ATE137334T1 (de) * 1991-02-28 1996-05-15 Boehringer Mannheim Gmbh Testträger zur bestimmung eines analyten aus vollblut
GB9113213D0 (en) * 1991-06-19 1991-08-07 Hypoguard Uk Ltd Support medium
GB9113211D0 (en) * 1991-06-19 1991-08-07 Hypoguard Uk Ltd Support membrane
US5179288A (en) * 1991-09-30 1993-01-12 Ortho Pharmaceutical Corporation Apparatus and method for measuring a bodily constituent
EP0555045B1 (en) * 1992-02-03 1997-10-08 Lifescan, Inc. Improved oxidative coupling dye for spectrophotometric quantitative analysis of analytes
DE4212280A1 (de) 1992-04-11 1993-10-14 Boehringer Mannheim Gmbh Asymmetrisch poröse Membranen
US5580744A (en) * 1992-04-27 1996-12-03 Avocet Medical, Inc. Test article and method for performing blood coagulation assays
AU4287593A (en) * 1992-04-27 1993-11-29 Avocet Medical, Inc. Test article and method for performing blood coagulation assays
GR1002549B (el) * 1992-05-12 1997-01-28 Lifescan Inc. Λωρις εξετασεως με μεταφορικο μεσο δια μεταφορα ρευστου.
US6330426B2 (en) 1994-05-23 2001-12-11 Stephen J. Brown System and method for remote education using a memory card
US8095340B2 (en) 1992-11-17 2012-01-10 Health Hero Network, Inc. Home power management system
US20010011224A1 (en) * 1995-06-07 2001-08-02 Stephen James Brown Modular microprocessor-based health monitoring system
US5956501A (en) 1997-01-10 1999-09-21 Health Hero Network, Inc. Disease simulation system and method
US5832448A (en) 1996-10-16 1998-11-03 Health Hero Network Multiple patient monitoring system for proactive health management
US5951300A (en) 1997-03-10 1999-09-14 Health Hero Network Online system and method for providing composite entertainment and health information
US8078407B1 (en) 1997-03-28 2011-12-13 Health Hero Network, Inc. System and method for identifying disease-influencing genes
US6196970B1 (en) 1999-03-22 2001-03-06 Stephen J. Brown Research data collection and analysis
US6968375B1 (en) * 1997-03-28 2005-11-22 Health Hero Network, Inc. Networked system for interactive communication and remote monitoring of individuals
US8078431B2 (en) 1992-11-17 2011-12-13 Health Hero Network, Inc. Home power management system
US9215979B2 (en) 1992-11-17 2015-12-22 Robert Bosch Healthcare Systems, Inc. Multi-user remote health monitoring system
US5307263A (en) 1992-11-17 1994-04-26 Raya Systems, Inc. Modular microprocessor-based health monitoring system
AU1766201A (en) * 1992-11-17 2001-05-30 Health Hero Network, Inc. Method and system for improving adherence with a diet program or other medical regimen
US20040019259A1 (en) * 1992-11-17 2004-01-29 Brown Stephen J. Remote monitoring and data management platform
US8027809B2 (en) 1992-11-17 2011-09-27 Health Hero Network, Inc. Home power management system
US7624028B1 (en) 1992-11-17 2009-11-24 Health Hero Network, Inc. Remote health monitoring and maintenance system
US5344754A (en) * 1993-01-13 1994-09-06 Avocet Medical, Inc. Assay timed by electrical resistance change and test strip
WO1994019767A1 (en) * 1993-02-26 1994-09-01 E-Y Laboratories, Inc. Optical specimen analysis system and method
US20010051352A1 (en) * 1993-04-15 2001-12-13 Gary Krantz Multilayer test strip
US5843691A (en) * 1993-05-15 1998-12-01 Lifescan, Inc. Visually-readable reagent test strip
DE4321548A1 (de) * 1993-06-29 1995-01-12 Boehringer Mannheim Gmbh Verfahren zum Erfassen und Auswerten analoger photometrischer Signale in einem Testträger-Analysesystem und Anordnung zur Durchführung des Verfahrens
US5837546A (en) * 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
US5710012A (en) * 1993-08-25 1998-01-20 Actimed Laboratories, Inc. Salt of 6-carboxy-3-methylbenzothiazolone hydrazone hydrate in colorimetric determination of hydrogen peroxide
US5408535A (en) * 1993-09-07 1995-04-18 Miles Inc. Video test strip reader and method for evaluating test strips
US5770389A (en) * 1993-09-27 1998-06-23 Abbott Laboratories Apparatus and method for determining the quanity of an analyte in a biological sample by means of transmission photometry
DE4337570A1 (de) * 1993-11-04 1995-05-11 Boehringer Mannheim Gmbh Verfahren zur Analyse von Glucose in einer biologischen Matrix
DE69431334T2 (de) * 1993-11-12 2003-09-18 Inverness Medical Switzerland Vorrichtung zum Ablesen von Teststreifen
US7141212B2 (en) * 1993-11-12 2006-11-28 Inverness Medical Switzerland Gmbh Reading devices and assay devices for use therewith
US5960344A (en) * 1993-12-20 1999-09-28 Norand Corporation Local area network having multiple channel wireless access
DE69523833T2 (de) * 1994-03-04 2002-04-04 Usf Filtration & Separations Gross-porige membran aus synthetischen polymeren
US5470752A (en) * 1994-06-29 1995-11-28 Lxn Corporation Multi-layer devices and methods of assaying for fructosamine
US5547702A (en) * 1994-07-08 1996-08-20 Polymer Technology International Corporation Method for continuous manufacture of diagnostic test strips
US5922530A (en) 1994-09-08 1999-07-13 Lifescan, Inc. Stable coupling dye for photometric determination of analytes
JP3488925B2 (ja) * 1994-09-08 2004-01-19 ライフスキヤン・インコーポレーテツド 条片上標準を備えた分析物検出用の光学読取式条片
US6335203B1 (en) 1994-09-08 2002-01-01 Lifescan, Inc. Optically readable strip for analyte detection having on-strip orientation index
US5563031A (en) * 1994-09-08 1996-10-08 Lifescan, Inc. Highly stable oxidative coupling dye for spectrophotometric determination of analytes
US5597532A (en) * 1994-10-20 1997-01-28 Connolly; James Apparatus for determining substances contained in a body fluid
US5559339A (en) * 1994-10-31 1996-09-24 Abbott Laboratories Method and apparatus for verifying dispense of a fluid from a dispense nozzle
US5728352A (en) * 1994-11-14 1998-03-17 Advanced Care Products Disposable electronic diagnostic instrument
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5695949A (en) * 1995-04-07 1997-12-09 Lxn Corp. Combined assay for current glucose level and intermediate or long-term glycemic control
US5755231A (en) * 1995-05-17 1998-05-26 Plus Bio, Inc. Test strip including integral specimen flow retarding structure
US5743262A (en) * 1995-06-07 1998-04-28 Masimo Corporation Blood glucose monitoring system
US7635597B2 (en) 1995-08-09 2009-12-22 Bayer Healthcare Llc Dry reagent particle assay and device having multiple test zones and method therefor
US5976891A (en) * 1995-08-22 1999-11-02 U.S. Philips Corporation Method for investigating non-linear optical behavior of a layer formed from first and second reactants
AU722471B2 (en) * 1995-10-17 2000-08-03 Lifescan, Inc. Blood glucose strip having reduced sensitivity to hematocrit
JP3274049B2 (ja) * 1995-11-15 2002-04-15 アークレイ株式会社 多孔性材料中の液体の光学的測定法
US6638415B1 (en) 1995-11-16 2003-10-28 Lifescan, Inc. Antioxidant sensor
US5981294A (en) * 1995-11-29 1999-11-09 Metrika, Inc. Device for blood separation in a diagnostic device
US6709869B2 (en) 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US5833923A (en) * 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay interface system
US5833924A (en) * 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay device and interface system
US5962333A (en) * 1996-01-25 1999-10-05 Multisorb Technologies, Inc. Medical diagnostic test strip with desiccant
US6678669B2 (en) 1996-02-09 2004-01-13 Adeza Biomedical Corporation Method for selecting medical and biochemical diagnostic tests using neural network-related applications
USD383550S (en) * 1996-02-09 1997-09-09 Lifescan, Inc. Reagent test strip
US5605837A (en) * 1996-02-14 1997-02-25 Lifescan, Inc. Control solution for a blood glucose monitor
US5753452A (en) * 1996-04-04 1998-05-19 Lifescan, Inc. Reagent test strip for blood glucose determination
IL120587A (en) * 1996-04-04 2000-10-31 Lifescan Inc Reagent test strip for determination of blood glucose
US5989845A (en) * 1996-04-05 1999-11-23 Mercury Diagnostics, Inc. Diagnostic compositions and devices utilizing same
US6040151A (en) 1998-03-10 2000-03-21 Mercury Diagnostics, Inc. Diagnostic compositions and devices utilizing same
US5962215A (en) * 1996-04-05 1999-10-05 Mercury Diagnostics, Inc. Methods for testing the concentration of an analyte in a body fluid
US5776719A (en) * 1997-07-07 1998-07-07 Mercury Diagnostics, Inc. Diagnostic compositions and devices utilizing same
US5724148A (en) * 1996-05-09 1998-03-03 Bayer Corporation Apparatus and method for determination of urine color
EP1579814A3 (en) 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US20020010406A1 (en) 1996-05-17 2002-01-24 Douglas Joel S. Methods and apparatus for expressing body fluid from an incision
US5846486A (en) * 1996-08-09 1998-12-08 Lifescan, Inc. Hollow frustum reagent test device
US6099802A (en) * 1996-08-09 2000-08-08 Lifescan, Inc. Hollow frustum reagent test device
US5753429A (en) * 1996-08-09 1998-05-19 Lifescan, Inc. Analyte concentration measurement using a hollow frustum
US5736103A (en) 1996-08-09 1998-04-07 Lifescan, Inc. Remote-dosing analyte concentration meter
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US5945345A (en) * 1996-08-27 1999-08-31 Metrika, Inc. Device for preventing assay interference using silver or lead to remove the interferant
US5714123A (en) * 1996-09-30 1998-02-03 Lifescan, Inc. Protective shield for a blood glucose strip
ES2401046T3 (es) 1996-10-30 2013-04-16 F.Hoffmann-La Roche Ag Sistema sincronizado de prueba de analitos
US6632349B1 (en) * 1996-11-15 2003-10-14 Lifescan, Inc. Hemoglobin sensor
US6071249A (en) * 1996-12-06 2000-06-06 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
WO1998028623A1 (en) 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
DE19880001T1 (de) * 1997-01-09 1999-03-18 Mercury Diagnostics Inc Verfahren zum Auftragen eines Reagens auf eine Analysentestvorrichtung
US6032119A (en) 1997-01-16 2000-02-29 Health Hero Network, Inc. Personalized display of health information
US6103141A (en) * 1997-01-23 2000-08-15 Multisorb Technologies, Inc. Desiccant deposit
US20050101032A1 (en) * 1997-02-10 2005-05-12 Metrika, Inc. Assay device, composition, and method of optimizing assay sensitivity
US7198955B1 (en) * 1997-03-03 2007-04-03 Nir Diagnostics Inc. Method and apparatus for measurement of blood substitutes
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US7192450B2 (en) * 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US20050033132A1 (en) 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
GB9705667D0 (en) * 1997-03-19 1997-05-07 Jackson James R Diagnostic and analytical devices
US5859937A (en) * 1997-04-04 1999-01-12 Neomecs Incorporated Minimally invasive sensor
US6063589A (en) 1997-05-23 2000-05-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
US6632399B1 (en) * 1998-05-22 2003-10-14 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays
US7049130B2 (en) * 1997-06-10 2006-05-23 Home Diagnostics, Inc. Diagnostic sanitary test strip
US6991940B2 (en) 1997-06-10 2006-01-31 Home Diagnostics, Inc. Diagnostic sanitary test strip
US6040195A (en) * 1997-06-10 2000-03-21 Home Diagnostics, Inc. Diagnostic sanitary test strip
US5948695A (en) * 1997-06-17 1999-09-07 Mercury Diagnostics, Inc. Device for determination of an analyte in a body fluid
US6168957B1 (en) * 1997-06-25 2001-01-02 Lifescan, Inc. Diagnostic test strip having on-strip calibration
US6066243A (en) * 1997-07-22 2000-05-23 Diametrics Medical, Inc. Portable immediate response medical analyzer having multiple testing modules
AUPO855897A0 (en) 1997-08-13 1997-09-04 Usf Filtration And Separations Group Inc. Automatic analysing apparatus II
US6121050A (en) * 1997-08-29 2000-09-19 Han; Chi-Neng Arthur Analyte detection systems
US6222619B1 (en) 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
HU222809B1 (hu) 1997-10-03 2003-10-28 77 Elektronika Műszeripari Kft. Eljárás és készülék kémiai összetevőnek anyagmintából, különösen vér glükóztartalmának vérmintából történő meghatározásához
US6574425B1 (en) * 1997-10-31 2003-06-03 Jack L. Aronowitz Reflectometer
US5968746A (en) 1997-11-26 1999-10-19 Schneider; David R. Method and apparatus for preserving human saliva for testing
US6303326B1 (en) 1997-12-04 2001-10-16 University Of Arkansas Insect salivary enzyme triggers systemic resistance
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US5997817A (en) * 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
US6069011A (en) * 1997-12-10 2000-05-30 Umm Electronics, Inc. Method for determining the application of a sample fluid on an analyte strip using first and second derivatives
US6009632A (en) * 1997-12-12 2000-01-04 Mercury Diagnostics, Inc. Alignment system for optical analyte testing meter components
US6162639A (en) * 1997-12-19 2000-12-19 Amira Medical Embossed test strip system
US7407811B2 (en) * 1997-12-22 2008-08-05 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC excitation
US7390667B2 (en) * 1997-12-22 2008-06-24 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC phase angle measurements
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US7494816B2 (en) * 1997-12-22 2009-02-24 Roche Diagnostic Operations, Inc. System and method for determining a temperature during analyte measurement
JPH11183474A (ja) * 1997-12-24 1999-07-09 Terumo Corp 試験紙および成分測定用チップ
US6394952B1 (en) 1998-02-03 2002-05-28 Adeza Biomedical Corporation Point of care diagnostic systems
US6267722B1 (en) 1998-02-03 2001-07-31 Adeza Biomedical Corporation Point of care diagnostic systems
JP4368060B2 (ja) 1998-02-17 2009-11-18 アボット・ラボラトリーズ 間質流体の収集及びモニタリングデバイス
EP1059882B1 (en) 1998-03-06 2007-10-17 SPECTRX, Inc. Integrated tissue poration, fluid harvesting and analysis device
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US5995236A (en) * 1998-04-13 1999-11-30 Mit Development Corporation Blood fluid characteristics analysis instrument
USD432244S (en) * 1998-04-20 2000-10-17 Adeza Biomedical Corporation Device for encasing an assay test strip
US6181417B1 (en) * 1998-04-20 2001-01-30 Bayer Corporation Photometric readhead with light-shaping plate
USD434153S (en) * 1998-04-20 2000-11-21 Adeza Biomedical Corporation Point of care analyte detector system
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
WO1999056111A1 (en) * 1998-04-28 1999-11-04 Akzo Nobel N.V. Electronic test device
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US20060019404A1 (en) * 1998-05-06 2006-01-26 Blatt Joel M Quantitative assay with extended dynamic range
US6325980B1 (en) * 1998-05-07 2001-12-04 Serim Research Corporation Test strip incubation device
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6312888B1 (en) 1998-06-10 2001-11-06 Abbott Laboratories Diagnostic assay for a sample of biological fluid
US6226082B1 (en) 1998-06-25 2001-05-01 Amira Medical Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy
US6518034B1 (en) * 1998-06-25 2003-02-11 Abb Diagnostics, Ltd. Test strip for blood glucose determination
ES2255168T3 (es) 1998-07-16 2006-06-16 Sapporo Immuno Diagnostic Laboratory Metodo de dosificado de l-fenilalanina y detector de l-fenilalanina.
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6830934B1 (en) * 1999-06-15 2004-12-14 Lifescan, Inc. Microdroplet dispensing for a medical diagnostic device
US6521182B1 (en) * 1998-07-20 2003-02-18 Lifescan, Inc. Fluidic device for medical diagnostics
EP1018004B1 (en) 1998-07-22 2006-11-22 Syntron Bioresearch, Inc. Multiple analyte assay device
JP4070050B2 (ja) * 1998-07-24 2008-04-02 テルモ株式会社 血糖値測定方法及び装置
US6493069B1 (en) 1998-07-24 2002-12-10 Terumo Kabushiki Kaisha Method and instrument for measuring blood sugar level
US6162397A (en) * 1998-08-13 2000-12-19 Lifescan, Inc. Visual blood glucose test strip
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US7640083B2 (en) 2002-11-22 2009-12-29 Monroe David A Record and playback system for aircraft
CA2341446C (en) 1998-08-31 2008-10-07 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
WO2000013573A1 (en) 1998-09-04 2000-03-16 Powderject Research Limited Monitoring methods using particle delivery methods
DE19840965A1 (de) 1998-09-08 2000-03-09 Disetronic Licensing Ag Vorrichtung zur Selbstverabreichung eines Produktfluids
AU6142799A (en) 1998-09-11 2000-03-27 Amira Medical Device for determination of an analyte in a body fluid intergrated with an insulin pump
IL126224A0 (en) * 1998-09-15 1999-05-09 Gerlitz Jonathan Ear thermometer and detector therefor
US8521546B2 (en) * 1998-09-25 2013-08-27 Health Hero Network Dynamic modeling and scoring risk assessment
US6656697B1 (en) * 1998-09-28 2003-12-02 Lifescan, Inc. Diagnostics based on tetrazolium compounds
DE19844500A1 (de) 1998-09-29 2000-03-30 Roche Diagnostics Gmbh Verfahren zur photometrischen Auswertung von Testelementen
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US6285454B1 (en) * 1998-12-07 2001-09-04 Mercury Diagnostics, Inc. Optics alignment and calibration system
JP2000262298A (ja) * 1999-03-15 2000-09-26 Fuji Photo Film Co Ltd 全血中のグルコース濃度もしくはコレステロール濃度の定量方法
JP3984748B2 (ja) * 1999-03-17 2007-10-03 株式会社日立製作所 化学分析装置と化学分析システム
US6551842B1 (en) 1999-03-26 2003-04-22 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6511814B1 (en) 1999-03-26 2003-01-28 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6602719B1 (en) 1999-03-26 2003-08-05 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
WO2000062857A1 (en) 1999-04-16 2000-10-26 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US8419650B2 (en) 1999-04-16 2013-04-16 Cariocom, LLC Downloadable datasets for a patient monitoring system
US6290646B1 (en) 1999-04-16 2001-09-18 Cardiocom Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients
US6150124A (en) * 1999-05-20 2000-11-21 Umm Electronics, Inc. Method for passively determining the application of a sample fluid on an analyte strip
US6685699B1 (en) 1999-06-09 2004-02-03 Spectrx, Inc. Self-removing energy absorbing structure for thermal tissue ablation
DE19926931A1 (de) 1999-06-14 2000-12-21 Roche Diagnostics Gmbh Verfahren und Vorrichtung zur Kontrolle der Flüssigkeitsaufnahme einer Testschicht eines Analyseelementes
ATE272213T1 (de) * 1999-06-18 2004-08-15 Gamera Bioscience Corp Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
US7223364B1 (en) 1999-07-07 2007-05-29 3M Innovative Properties Company Detection article having fluid control film
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
WO2001006253A2 (en) 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System Detection system based on an analyte reactive particle
HK1023262A2 (en) * 1999-07-30 2000-07-28 Chong De Yao Family-use health examination card and its explainer
US6488890B1 (en) 1999-08-05 2002-12-03 3M Innovative Properties Company Machine readable sterilization indicator for monitoring articles to be sterilized
US6884394B1 (en) 1999-08-05 2005-04-26 3M Innovative Properties Company Chemical indicator reader
US6485979B1 (en) * 1999-08-05 2002-11-26 3M Innovative Properties Company Electronic system for tracking and monitoring articles to be sterilized and associated method
US6485978B1 (en) 1999-08-05 2002-11-26 3M Innovative Properties Company Method of using a chemical indicator
US6562297B1 (en) * 1999-08-12 2003-05-13 Common Sense Ltd. pH sensor for indicating the pH of a sample
US20050103624A1 (en) * 1999-10-04 2005-05-19 Bhullar Raghbir S. Biosensor and method of making
US6218571B1 (en) 1999-10-27 2001-04-17 Lifescan, Inc. 8-(anilino)-1-naphthalenesulfonate analogs
US6361960B1 (en) 1999-11-09 2002-03-26 Environmentally Sensitive Solutions, Inc. Method and test kit for measuring concentration of a cleaning agent in a wash liquor
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US6316264B1 (en) * 1999-12-17 2001-11-13 Bayer Corporation Test strip for the assay of an analyte in a liquid sample
WO2001055704A1 (en) * 2000-01-31 2001-08-02 Board Of Regents, The University Of Texas System System for transferring fluid samples through a sensor array
US6485923B1 (en) * 2000-02-02 2002-11-26 Lifescan, Inc. Reagent test strip for analyte determination having hemolyzing agent
US20010037060A1 (en) * 2000-02-08 2001-11-01 Thompson Richard P. Web site for glucose monitoring
ES2279805T3 (es) * 2000-03-09 2007-09-01 Clinical Analysis Corp. Sistema de diagnostico medico.
WO2001073405A1 (en) * 2000-03-24 2001-10-04 Umm Electronics, Inc. Symmetric optical analysis device
US6632844B1 (en) 2000-03-29 2003-10-14 Washington University Methods and compositions for preserving glucose level in blood specimens
DE10020445B4 (de) * 2000-04-26 2005-09-29 Schlagheck Design Gmbh Blutzuckermeßstreifen
US7228077B2 (en) * 2000-05-12 2007-06-05 Forster Energy Llc Channel gain control for an optical communications system utilizing frequency division multiplexing
US6863866B2 (en) 2000-06-02 2005-03-08 Biocontrol Systems, Inc. Self-contained devices for detecting biological contaminants
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
RU2278612C2 (ru) 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
EP1358459B1 (en) * 2000-08-01 2006-10-11 Charm Sciences Inc. Hygiene monitoring
US6549861B1 (en) 2000-08-10 2003-04-15 Euro-Celtique, S.A. Automated system and method for spectroscopic analysis
EP1311189A4 (en) 2000-08-21 2005-03-09 Euro Celtique Sa Near-BLOOD GLUCOSE MONITORING DEVICE
CN102012413B (zh) * 2000-09-25 2012-11-21 松下电器产业株式会社 色层分析定量测量装置
US6555061B1 (en) * 2000-10-05 2003-04-29 Lifescan, Inc. Multi-layer reagent test strip
EP1410001A4 (en) * 2000-10-25 2006-05-31 Michael M Miller MULTI-LAYERED ANALYTICAL ELEMENT AND METHOD OF DETERMINING ANALYTES IN FLUIDS CONTAINING INTERFERING SUBSTANCES
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6800488B2 (en) 2000-12-13 2004-10-05 Lifescan, Inc. Methods of manufacturing reagent test strips
US6635439B2 (en) * 2000-12-21 2003-10-21 Ethicon, Inc. Hydrogen peroxide indicator employing enzyme and dye
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7195923B2 (en) * 2001-01-31 2007-03-27 Scripps Laboratories, Inc. Ratiometric determination of glycated protein
US20030003436A1 (en) * 2001-02-05 2003-01-02 Willson C. Grant Use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors
DE10105549A1 (de) 2001-02-06 2002-08-29 Roche Diagnostics Gmbh System zur Überwachung der Konzentration von Analyten in Körperflüssigkeiten
US6850633B2 (en) * 2001-02-23 2005-02-01 Beckman Coulter, Inc. Devices and methods for reading and interpreting guaiac-based occult blood tests
US6541266B2 (en) * 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6525330B2 (en) * 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6562625B2 (en) * 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US20060108218A1 (en) * 2001-03-05 2006-05-25 Clinical Analysis Corporation Test cell for use with medical diagnostic instrument
GB2373852B (en) * 2001-03-26 2005-06-08 Capital Controls Ltd Portable light detector
EP1397068A2 (en) * 2001-04-02 2004-03-17 Therasense, Inc. Blood glucose tracking apparatus and methods
US6753187B2 (en) * 2001-05-09 2004-06-22 Lifescan, Inc. Optical component based temperature measurement in analyte detection devices
JP3934107B2 (ja) * 2001-06-08 2007-06-20 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 体液を収集するための試験片および体液を収集する方法
WO2002100274A1 (en) * 2001-06-08 2002-12-19 Hoffmann-La Roche Ag Bodily fluid sampling device and test media cassette to be used with such a device
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1395185B1 (en) 2001-06-12 2010-10-27 Pelikan Technologies Inc. Electric lancet actuator
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
CA2448902C (en) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US6837988B2 (en) * 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
ES2357887T3 (es) 2001-06-12 2011-05-03 Pelikan Technologies Inc. Aparato para mejorar la tasa de éxito de obtención de sangre a partir de una punción capilar.
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US6444169B1 (en) 2001-06-18 2002-09-03 Ralston Purina Company Test-device for threshold glucose detection in urine
US6576416B2 (en) 2001-06-19 2003-06-10 Lifescan, Inc. Analyte measurement device and method of use
US6844149B2 (en) * 2001-06-29 2005-01-18 International Business Machines Corporation Method, system, and apparatus for measurement and recording of blood chemistry and other physiological measurements
US7776608B2 (en) * 2001-07-09 2010-08-17 Bayer Healthcare Llc Volume meter testing device and method of use
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US6678542B2 (en) * 2001-08-16 2004-01-13 Optiscan Biomedical Corp. Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements
US6884592B2 (en) * 2001-09-05 2005-04-26 Lifescan, Inc. Devices for analyte concentration determination and methods of manufacturing and using the same
US20040229347A1 (en) * 2001-09-17 2004-11-18 Perez Edward P. Embossed test strip system
MXPA04002687A (es) * 2001-09-24 2004-06-18 Atsuo F Fukunaga Circuitos respiratorios que tienen conductos y sistemas respiratorios no convencionales y metodos para optimizar la utilizacion de gases puros.
US20030113227A1 (en) * 2001-09-26 2003-06-19 Eyster Curt R. Colorimetric test device with reduced error
US6984307B2 (en) * 2001-10-05 2006-01-10 Stephen Eliot Zweig Dual glucose-hydroxybutyrate analytical sensors
US7758744B2 (en) * 2001-10-05 2010-07-20 Stephen Eliot Zweig Dual glucose-turbidimetric analytical sensors
KR20030032809A (ko) * 2001-10-17 2003-04-26 장준근 적혈구의 물리적 특성을 이용한 질환 진단 장치 및 그진단 방법
US20030077205A1 (en) * 2001-10-24 2003-04-24 Xu Tom C. Diagnostic test optical fiber tips
US7018843B2 (en) * 2001-11-07 2006-03-28 Roche Diagnostics Operations, Inc. Instrument
US7061593B2 (en) * 2001-11-08 2006-06-13 Optiscan Biomedical Corp. Device and method for in vitro determination of analyte concentrations within body fluids
US6989891B2 (en) * 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
CA2464738A1 (en) * 2001-11-09 2003-05-15 Dow Global Technologies Inc. Hand-held medical apparatus
US7794994B2 (en) * 2001-11-09 2010-09-14 Kemeta, Llc Enzyme-based system and sensor for measuring acetone
EP1448489B1 (en) * 2001-11-16 2010-08-25 Stefan Ufer Flexible sensor and method of fabrication
DE10156804B4 (de) * 2001-11-20 2011-03-17 Quidel Corp., San Diego Optische Meßvorrichtung für Teststreifen
US7623240B2 (en) * 2001-11-20 2009-11-24 Iris Deutschland Gmbh Optical measuring device for test strips
US6689411B2 (en) 2001-11-28 2004-02-10 Lifescan, Inc. Solution striping system
US6749887B1 (en) * 2001-11-28 2004-06-15 Lifescan, Inc. Solution drying system
US6723500B2 (en) 2001-12-05 2004-04-20 Lifescan, Inc. Test strips having reaction zones and channels defined by a thermally transferred hydrophobic barrier
CA2470772A1 (en) 2001-12-17 2003-06-26 Terry L. Burkoth Non-or minimally invasive monitoring methods
US6952604B2 (en) 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
DE10163775A1 (de) * 2001-12-22 2003-07-03 Roche Diagnostics Gmbh Analysensystem zur Bestimmung einer Analytkonzentration unter Berücksichtigung von proben- und analytunabhängigen Lichtintensitätsänderungen
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
JP2005515429A (ja) * 2001-12-27 2005-05-26 インバーネス・メデイカル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 蛍光検出用のシステムおよび方法
US6872358B2 (en) * 2002-01-16 2005-03-29 Lifescan, Inc. Test strip dispenser
US20030216628A1 (en) * 2002-01-28 2003-11-20 Bortz Jonathan David Methods and systems for assessing glycemic control using predetermined pattern label analysis of blood glucose readings
US7004928B2 (en) * 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US20030212379A1 (en) * 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
CA2419199A1 (en) * 2002-03-05 2003-09-05 Bayer Healthcare, Llc Minimum invasive optical format with integrated lance
CA2419213C (en) * 2002-03-07 2011-06-21 Bayer Healthcare Llc Improved electrical sensor
US20060134713A1 (en) 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US20030180814A1 (en) * 2002-03-21 2003-09-25 Alastair Hodges Direct immunosensor assay
AUPS177202A0 (en) * 2002-04-16 2002-05-23 Diakyne Pty Ltd Multi-element screening of trace elements
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US20070142748A1 (en) * 2002-04-19 2007-06-21 Ajay Deshmukh Tissue penetration device
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7198606B2 (en) 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
AU2003228711C1 (en) 2002-04-26 2010-01-07 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US20030207441A1 (en) * 2002-05-01 2003-11-06 Eyster Curt R. Devices and methods for analyte concentration determination
US6847451B2 (en) * 2002-05-01 2005-01-25 Lifescan, Inc. Apparatuses and methods for analyte concentration determination
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US20030212344A1 (en) * 2002-05-09 2003-11-13 Vadim Yuzhakov Physiological sample collection devices and methods of using the same
US7343188B2 (en) * 2002-05-09 2008-03-11 Lifescan, Inc. Devices and methods for accessing and analyzing physiological fluid
US20030223906A1 (en) * 2002-06-03 2003-12-04 Mcallister Devin Test strip container system
GB2418258B (en) 2002-06-05 2006-08-23 Diabetes Diagnostics Inc Analyte testing device
US20040067481A1 (en) * 2002-06-12 2004-04-08 Leslie Leonard Thermal sensor for fluid detection
US6759190B2 (en) * 2002-06-15 2004-07-06 Acon Laboratories, Inc. Test strip for detection of analyte and methods of use
US20040018114A1 (en) * 2002-07-26 2004-01-29 Chia-Lin Wang Test strip holder for a reagent test strip
DE10245508A1 (de) * 2002-09-27 2004-04-08 Mcs Micro Carrier Systems Gmbh Medikament-Dosimeter-Kombipackung
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
DE10248555B4 (de) 2002-10-18 2004-12-02 Roche Diagnostics Gmbh Verfahren und Analysesystem zur Ermittlung der Konzentration eines Analyten in einer Probe, die aus dem Analyten und der Probenmatrix besteht und Testelement dafür
US20040087874A1 (en) * 2002-10-28 2004-05-06 David Schneider Saliva collection system
US7731900B2 (en) * 2002-11-26 2010-06-08 Roche Diagnostics Operations, Inc. Body fluid testing device
AU2003300598A1 (en) * 2002-12-12 2004-07-09 L'oreal-Ferrari Non-transfer cosmetic composition comprising a dispersion of a grafted ethylene polymer
AU2003297205A1 (en) * 2002-12-13 2004-07-09 Pelikan Technologies, Inc. Method and apparatus for measuring analytes
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US7582258B2 (en) * 2002-12-23 2009-09-01 Roche Diagnostics Operations, Inc. Body fluid testing device
EP2289416B1 (en) 2002-12-23 2014-08-20 Roche Diagnostics GmbH Body fluid testing device
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7811231B2 (en) 2002-12-31 2010-10-12 Abbott Diabetes Care Inc. Continuous glucose monitoring system and methods of use
US6983177B2 (en) * 2003-01-06 2006-01-03 Optiscan Biomedical Corporation Layered spectroscopic sample element with microporous membrane
US20040131088A1 (en) * 2003-01-08 2004-07-08 Adtran, Inc. Shared T1/E1 signaling bit processor
GB2397375A (en) * 2003-01-14 2004-07-21 Hypoguard Ltd Measuring analyte concentration in a fluid sample by illuminating the sample at two wavelengths
JP4405967B2 (ja) * 2003-01-27 2010-01-27 テルモ株式会社 体液成分分析システム
US7214542B2 (en) * 2003-01-30 2007-05-08 Michael Hutchinson Method of processing assay test results
US7220597B2 (en) * 2003-01-30 2007-05-22 Zin Benedict L Assay test device and method of making same
CA2455669A1 (en) * 2003-02-04 2004-08-04 Bayer Healthcare, Llc Method and test strip for determining glucose in blood
EP1447665B1 (en) * 2003-02-11 2016-06-29 Bayer HealthCare LLC Method for reducing effect of hematocrit on measurement of an analyte in whole blood
US7379167B2 (en) 2003-02-11 2008-05-27 International Technidyne Corporation Hemoglobin test strip and analysis system
US20040163987A1 (en) 2003-02-25 2004-08-26 John Allen Automatically opening medical device package and method of manufacture
US6900058B2 (en) * 2003-03-11 2005-05-31 Bionostics, Inc. Control solution for photometric analysis
US7052652B2 (en) * 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US7587287B2 (en) 2003-04-04 2009-09-08 Abbott Diabetes Care Inc. Method and system for transferring analyte test data
US20050106749A1 (en) * 2003-04-15 2005-05-19 Braig James R. Sample element for use in material analysis
EP1618389A1 (en) * 2003-04-15 2006-01-25 Optiscan Biomedical Corporation Sample element qualification
WO2004091387A2 (en) * 2003-04-15 2004-10-28 Optiscan Biomedical Corporation Dual measurement analyte detection system
US20050037384A1 (en) * 2003-04-15 2005-02-17 Braig James R. Analyte detection system
US20040214345A1 (en) * 2003-04-23 2004-10-28 Matzinger David P. Ambidextrous capillary-filled test strip
WO2004097371A2 (en) * 2003-04-25 2004-11-11 Board Of Regents, The University Of Texas System System and method for the detection of analytes
US20040219691A1 (en) * 2003-04-29 2004-11-04 Shartle Robert J. Test strip with clear base support layer for visual perception of a liquid sample during application
EP1620021A4 (en) * 2003-05-02 2008-06-18 Pelikan Technologies Inc METHOD AND DEVICE FOR A USER INTERFACE FOR A TISSUE PEGETRATION DEVICE
US7399276B1 (en) * 2003-05-08 2008-07-15 Health Hero Network, Inc. Remote health monitoring system
JP2004343275A (ja) * 2003-05-14 2004-12-02 Murata Mach Ltd 画像処理システム及びスキャナ装置
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
WO2004104922A2 (en) * 2003-05-16 2004-12-02 Board Of Regents, The University Of Texas System Image and part recognition technology
US7875293B2 (en) 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
US8153081B2 (en) 2003-05-29 2012-04-10 Bayer Healthcare Llc Test sensor and method for manufacturing the same
EP1628567B1 (en) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Method and apparatus for fluid injection
US7239394B2 (en) 2003-06-04 2007-07-03 Inverness Medical Switzerland Gmbh Early determination of assay results
US7317532B2 (en) * 2003-06-04 2008-01-08 Inverness Medical Switzerland Gmbh Flow sensing for determination of assay results
US7315378B2 (en) * 2003-06-04 2008-01-01 Inverness Medical Switzerland Gmbh Optical arrangement for assay reading device
ES2490740T3 (es) 2003-06-06 2014-09-04 Sanofi-Aventis Deutschland Gmbh Aparato para toma de muestras de fluido sanguíneo y detección de analitos
US8460243B2 (en) 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US20060241666A1 (en) * 2003-06-11 2006-10-26 Briggs Barry D Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US8679853B2 (en) * 2003-06-20 2014-03-25 Roche Diagnostics Operations, Inc. Biosensor with laser-sealed capillary space and method of making
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
ES2683013T3 (es) * 2003-06-20 2018-09-24 F. Hoffmann-La Roche Ag Banda de reactivo para tira de ensayo
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US8071030B2 (en) * 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
US7597793B2 (en) * 2003-06-20 2009-10-06 Roche Operations Ltd. System and method for analyte measurement employing maximum dosing time delay
US7220034B2 (en) * 2003-07-11 2007-05-22 Rudolph Technologies, Inc. Fiber optic darkfield ring light
US7722536B2 (en) 2003-07-15 2010-05-25 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
WO2007120442A2 (en) 2003-07-25 2007-10-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US20050056552A1 (en) * 2003-07-25 2005-03-17 Simpson Peter C. Increasing bias for oxygen production in an electrode system
US8676287B2 (en) 2003-08-01 2014-03-18 Dexcom, Inc. System and methods for processing analyte sensor data
US8285354B2 (en) 2003-08-01 2012-10-09 Dexcom, Inc. System and methods for processing analyte sensor data
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US8845536B2 (en) 2003-08-01 2014-09-30 Dexcom, Inc. Transcutaneous analyte sensor
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US6931327B2 (en) 2003-08-01 2005-08-16 Dexcom, Inc. System and methods for processing analyte sensor data
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US7273591B2 (en) 2003-08-12 2007-09-25 Idexx Laboratories, Inc. Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20070066873A1 (en) 2003-08-22 2007-03-22 Apurv Kamath Systems and methods for processing analyte sensor data
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE
US20050071516A1 (en) * 2003-09-30 2005-03-31 International Business Machines Corporation Method and apparatus to autonomically profile applications
WO2005036144A1 (en) * 2003-10-03 2005-04-21 Bayer Healthcare Llc Precision correction of reflectance measurements
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc METHOD AND APPARATUS PROVIDING A VARIABLE USER INTERFACE
US20050090607A1 (en) * 2003-10-28 2005-04-28 Dexcom, Inc. Silicone composition for biocompatible membrane
WO2005043123A2 (en) * 2003-10-31 2005-05-12 Queststar Medical, Inc. System and apparatus for body fluid analysis using surface-textured optical materials
US7713229B2 (en) 2003-11-06 2010-05-11 Lifescan, Inc. Drug delivery pen with event notification means
US7378270B2 (en) * 2003-11-10 2008-05-27 Sentec Scientific, Inc. Device for analyte measurement
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7713748B2 (en) * 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
DE10356452A1 (de) * 2003-12-03 2005-07-07 Roche Diagnostics Gmbh Schnelldiagnosegerät mit Verriegelung durch Teststreifen
US7588733B2 (en) * 2003-12-04 2009-09-15 Idexx Laboratories, Inc. Retaining clip for reagent test slides
ATE480761T1 (de) 2003-12-05 2010-09-15 Dexcom Inc Kalibrationsmethoden für einen kontinuierlich arbeitenden analytsensor
US8532730B2 (en) 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US7410808B1 (en) * 2003-12-08 2008-08-12 Charm Sciences, Inc. Method and assay for detection of residues
WO2005057175A2 (en) 2003-12-09 2005-06-23 Dexcom, Inc. Signal processing for continuous analyte sensor
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
WO2005065414A2 (en) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
KR20070070257A (ko) * 2004-01-09 2007-07-03 가부시키가이샤 이마이 패시브형 방산 플럭스 샘플러
US7150995B2 (en) * 2004-01-16 2006-12-19 Metrika, Inc. Methods and systems for point of care bodily fluid analysis
US7283245B2 (en) * 2004-01-20 2007-10-16 General Electric Company Handheld device with a disposable element for chemical analysis of multiple analytes
DE102004006470B4 (de) * 2004-02-06 2006-06-01 Senova Gesellschaft für Biowissenschaft und Technik mbH Absorptionsphotometrisches Verfahren zur quantitativen Stoffanalyse
BRPI0507376A (pt) 2004-02-06 2007-07-10 Bayer Healthcare Llc espécie oxidável como uma referência interna para biossensores e método de uso
CA2556331A1 (en) 2004-02-17 2005-09-29 Therasense, Inc. Method and system for providing data communication in continuous glucose monitoring and management system
DE102004007983A1 (de) * 2004-02-18 2005-09-08 Roche Diagnostics Gmbh Testelement mit Einschicht-Reaktionsfilm
US20070207554A1 (en) * 2004-02-26 2007-09-06 Lin Alex C C Medical System and Method for Determining Parameters
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
WO2009048462A1 (en) 2007-10-09 2009-04-16 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
EP1735618A2 (en) * 2004-02-27 2006-12-27 Board of Regents, The University of Texas System System and method for integrating fluids and reagents in self-contained cartridges containing particle and membrane sensor elements
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
PL1725168T3 (pl) * 2004-03-06 2016-10-31 Urządzenie do pobierania próbki płynu ustrojowego
US7819822B2 (en) * 2004-03-06 2010-10-26 Roche Diagnostics Operations, Inc. Body fluid sampling device
US20050227370A1 (en) * 2004-03-08 2005-10-13 Ramel Urs A Body fluid analyte meter & cartridge system for performing combined general chemical and specific binding assays
DE102004013699A1 (de) * 2004-03-18 2005-10-06 Tesa Ag Haftklebeband für medizinische Diagnosestreifen
US20050221504A1 (en) * 2004-04-01 2005-10-06 Petruno Patrick T Optoelectronic rapid diagnostic test system
US8128871B2 (en) * 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
US7521259B2 (en) * 2004-04-01 2009-04-21 Alverix, Inc. Assay test strips with multiple labels and reading same
US20070185679A1 (en) * 2004-04-01 2007-08-09 Petruno Patrick T Indicating status of a diagnostic test system
US20070143035A1 (en) * 2005-12-19 2007-06-21 Petruno Patrick T Diagnostic test reader with disabling unit
CN1869694B (zh) * 2004-04-09 2010-09-08 江门创元电子有限公司 便携式标本分析装置以及便携式尿分析装置
US20050264815A1 (en) * 2004-05-07 2005-12-01 Mark Wechsler Sample element with fringing-reduction capabilities
US7468272B2 (en) * 2004-05-10 2008-12-23 3M Innovative Properties Company Biological soil detector
US7524673B2 (en) 2004-05-10 2009-04-28 3M Innovative Properties Company Biological soil detector
US7972861B2 (en) * 2004-05-14 2011-07-05 Bayer Healthcare Llc Methods for performing hematocrit adjustment in glucose assays and devices for same
JP2007537454A (ja) * 2004-05-14 2007-12-20 バイエル・ヘルスケア・エルエルシー 液状サンプル中のアナライトを収集し、検出するための診断用試験条片、およびそれを使用する方法
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
CA3090413C (en) 2004-06-04 2023-10-10 Abbott Diabetes Care Inc. Glucose monitoring and graphical representations in a data management system
US7556723B2 (en) * 2004-06-18 2009-07-07 Roche Diagnostics Operations, Inc. Electrode design for biosensor
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
WO2006000505A2 (de) * 2004-06-23 2006-01-05 Tesa Ag Medizinischer biosensor, mittels dem biologische flüssigkeiten untersucht werden
US20060002817A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
US20060000709A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Methods for modulation of flow in a flow pathway
US20060001551A1 (en) * 2004-06-30 2006-01-05 Ulrich Kraft Analyte monitoring system with wireless alarm
US8343074B2 (en) 2004-06-30 2013-01-01 Lifescan Scotland Limited Fluid handling devices
US7763454B2 (en) * 2004-07-09 2010-07-27 Church & Dwight Co., Inc. Electronic analyte assaying device
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US7640048B2 (en) 2004-07-13 2009-12-29 Dexcom, Inc. Analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
WO2006127694A2 (en) 2004-07-13 2006-11-30 Dexcom, Inc. Analyte sensor
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US20060016700A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US20060024835A1 (en) 2004-07-30 2006-02-02 Matzinger David P Analytical test strip with control zone
WO2006026741A1 (en) * 2004-08-31 2006-03-09 Lifescan Scotland Limited Wearable sensor device and system
US7308164B1 (en) 2004-09-16 2007-12-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for texturing surfaces of optical fiber sensors used for blood glucose monitoring
US7501011B2 (en) * 2004-11-09 2009-03-10 Multisorb Technologies, Inc. Humidity control device
US7447168B2 (en) * 2004-11-10 2008-11-04 Avago Technologies General Ip (Singapore) Pte. Ltd. System and method for auto-negotiation in a data communication device
JP2006153497A (ja) * 2004-11-25 2006-06-15 Toshiba Corp グルコースセンシング膜用塗布液の調製方法および光学式グルコースセンサチップの製造方法
JP2008523413A (ja) 2004-12-13 2008-07-03 バイエル・ヘルスケア・エルエルシー 体液中の検体の測定に使用する透過分光システム
US20080214917A1 (en) * 2004-12-30 2008-09-04 Dirk Boecker Method and apparatus for analyte measurement test time
US20060167382A1 (en) * 2004-12-30 2006-07-27 Ajay Deshmukh Method and apparatus for storing an analyte sampling and measurement device
US20090054811A1 (en) * 2004-12-30 2009-02-26 Dirk Boecker Method and apparatus for analyte measurement test time
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
FR2881828B1 (fr) * 2005-02-04 2007-11-30 Diagnostica Stago Soc Par Acti Methode de mesure quantitative par immunochromatographie, d'analytes dans un echantillon liquide
EP1844332A1 (fr) * 2005-02-04 2007-10-17 Diagnostica Stago Methode de mesure quantitative par immunochromatographie, d'analytes dans un echantillon liquide
US20060184065A1 (en) * 2005-02-10 2006-08-17 Ajay Deshmukh Method and apparatus for storing an analyte sampling and measurement device
US20070103678A1 (en) * 2005-02-14 2007-05-10 Sterling Bernhard B Analyte detection system with interferent identification and correction
JP4479539B2 (ja) * 2005-02-23 2010-06-09 ウシオ電機株式会社 反射率測定装置
US20060188995A1 (en) * 2005-02-24 2006-08-24 Ryan Wayne L Process, composition and kit for providing a stable whole blood calibrator/control
WO2006110193A2 (en) 2005-04-08 2006-10-19 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
US20060249381A1 (en) * 2005-05-05 2006-11-09 Petisce James R Cellulosic-based resistance domain for an analyte sensor
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US9891217B2 (en) * 2005-04-22 2018-02-13 Alverix, Inc. Assay test strips with multiple labels and reading same
US7803319B2 (en) 2005-04-29 2010-09-28 Kimberly-Clark Worldwide, Inc. Metering technique for lateral flow assay devices
US7858384B2 (en) 2005-04-29 2010-12-28 Kimberly-Clark Worldwide, Inc. Flow control technique for assay devices
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US20060264783A1 (en) * 2005-05-09 2006-11-23 Holmes Elizabeth A Systems and methods for monitoring pharmacological parameters
US7767927B2 (en) * 2005-05-16 2010-08-03 Ultratech, Inc. Methods and apparatus for remote temperature measurement of a specular surface
US20060263265A1 (en) * 2005-05-23 2006-11-23 Der-Ren Kang Blood micro-separator
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US7499170B2 (en) 2005-07-13 2009-03-03 Fcc, Llc System and method for reading a test strip
ES2717135T3 (es) 2005-07-20 2019-06-19 Ascensia Diabetes Care Holdings Ag Método para señalar al usuario para que añada una muestra adicional a una tira de prueba, método para medir la temperatura de una muestra y métodos para determinar la concentración de un analito basados en amperometría controlada
GB0516099D0 (en) * 2005-08-05 2005-09-14 Cambridge Diagnostics Ireland Assay reading device with display
US20080227134A9 (en) * 2005-09-16 2008-09-18 Unigene Laboratories Inc. Glyoxylate assays and their use of inden tifying natural amidated compounds
WO2007035555A1 (en) * 2005-09-16 2007-03-29 University Of South Florida Materials and methods for assaying for glyoxylate
US20070073191A1 (en) * 2005-09-26 2007-03-29 Anne Thomson Device for promoting bodily fluid expression from a target site
KR101577176B1 (ko) 2005-09-30 2015-12-14 바이엘 헬스케어 엘엘씨 게이트형 전압 전류 측정 분석물 결정 방법
EP2989981B8 (en) 2005-09-30 2018-09-05 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US20070276290A1 (en) * 2005-10-04 2007-11-29 Dirk Boecker Tissue Penetrating Apparatus
US20070191736A1 (en) * 2005-10-04 2007-08-16 Don Alden Method for loading penetrating members in a collection device
US20090196580A1 (en) * 2005-10-06 2009-08-06 Freeman Dominique M Method and apparatus for an analyte detecting device
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US8632730B2 (en) * 2005-11-22 2014-01-21 Alverix, Inc. Assaying test strips having different capture reagents
US20070122914A1 (en) * 2005-11-30 2007-05-31 Curry Bo U Obtaining measurements of light transmitted through an assay test strip
US8491850B2 (en) * 2005-12-19 2013-07-23 Alverix, Inc. Diagnostic test reader with locking mechanism
EP2004796B1 (en) * 2006-01-18 2015-04-08 DexCom, Inc. Membranes for an analyte sensor
US20070188736A1 (en) * 2006-02-16 2007-08-16 Fouquet Julie E Obtaining measurement and baseline signals for evaluating assay test strips
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US20090093735A1 (en) * 2006-03-29 2009-04-09 Stephan Korner Test unit and test system for analyzing body fluids
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
EP2023802A2 (en) * 2006-05-08 2009-02-18 Bayer Healthcare, LLC Test sensor with under-fill protection
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20070267513A1 (en) * 2006-05-17 2007-11-22 Taylor William A Low profile fountain or water display
US7920907B2 (en) 2006-06-07 2011-04-05 Abbott Diabetes Care Inc. Analyte monitoring system and method
US7993512B2 (en) 2006-07-11 2011-08-09 Bayer Healthcare, Llc Electrochemical test sensor
DE102006032667A1 (de) * 2006-07-13 2008-01-17 Tesa Ag Bahnförmiges Material mit einer Beschichtung, die ein sehr schnelles Spreiten beziehungsweise einen sehr schnellen Transport von Flüssigkeiten ermöglicht
US8703057B2 (en) 2006-08-08 2014-04-22 Hach Company Electronic device for analyzing aqueous solutions
US8142722B2 (en) * 2006-08-08 2012-03-27 Hach Company Test element and tester for analyzing solutions
SE530596C2 (sv) * 2006-10-13 2008-07-15 Mathias Karlsson Metod att fastställa syrebrist i blod från skalpen under förlossning
US20080101987A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Analytical test strip with electroluminescent lamp
US20080101984A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Method for determining an analyte in a bodily fluid sample
US20080100689A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Method for manufacturing an analytical test strip with an electroluminescent component
US7740801B2 (en) * 2006-10-31 2010-06-22 Lifescan Scotland Limited System for determination of an analyte in a bodily fluid sample that includes an electroluminescent component
US7740580B2 (en) * 2006-10-31 2010-06-22 Abbott Diabetes Care Inc. Analyte monitoring
US20080101986A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Analytical test strip with electroluminescent module
CA2608609A1 (en) 2006-10-31 2008-04-30 Lefescan Scotland Limited Analytical test strip with electroluminescent lamp
US8158081B2 (en) * 2006-10-31 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring devices
JP2008116452A (ja) 2006-10-31 2008-05-22 Lifescan Scotland Ltd 電子発光モジュールを有する分析用試験片
US20080113391A1 (en) * 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
WO2008082987A2 (en) * 2006-12-26 2008-07-10 Abbott Diabetes Care Inc Analyte meter protectors and methods
GB2445161B (en) * 2006-12-29 2011-08-10 Mologic Ltd Diagnostic test device
GB2445187B (en) * 2006-12-29 2010-10-27 Mologic Ltd Diagnostic test device
DE102007003755A1 (de) 2007-01-19 2008-07-31 Tesa Ag Bahnförmiges Material mit einer Beschichtung, die ein dauerhaftes schnelles Spreiten beziehungsweise einen dauerhaften sehr schnellen Transport von Flüssigkeiten ermöglicht
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
WO2008118764A1 (en) * 2007-03-23 2008-10-02 Miox Corporation Carbonate scale detector
US20080267446A1 (en) * 2007-04-18 2008-10-30 Dale Capewell Chemistry strip reader and method
US8150115B2 (en) * 2007-04-18 2012-04-03 Iris International, Inc. Chemistry strip reader and method
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
WO2008140742A1 (en) 2007-05-08 2008-11-20 Idexx Laboratories, Inc. Chemical analyzer
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8313710B2 (en) 2007-05-15 2012-11-20 Polestar Technologies, Inc. Multilayered optical sensing patch and retaining plug therefor
US20080286154A1 (en) * 2007-05-15 2008-11-20 Polestar Technologies, Inc. Multilayered optical sensing patch and retaining plug therefor
US8597190B2 (en) 2007-05-18 2013-12-03 Optiscan Biomedical Corporation Monitoring systems and methods with fast initialization
US20080294024A1 (en) * 2007-05-24 2008-11-27 Cosentino Daniel L Glucose meter system and monitor
WO2008154312A1 (en) 2007-06-08 2008-12-18 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
GB2450351B (en) 2007-06-20 2012-01-18 Cozart Bioscience Ltd Monitoring an Immunoassay
CN103418295B (zh) 2007-06-21 2015-11-18 简.探针公司 用于混合检测腔室的内容物的仪器和方法
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
WO2009025616A1 (en) * 2007-08-22 2009-02-26 Phadia Ab Read-out method and apparatus
PL2040072T3 (pl) * 2007-09-22 2013-06-28 Hoffmann La Roche System analityczny do określania koncentracji analitu w płynie ustrojowym
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
WO2009076271A2 (en) * 2007-12-10 2009-06-18 Bayer Healthcare Llc Wear-resistant electrochemical test sensor and method of forming the same
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
US20090209883A1 (en) * 2008-01-17 2009-08-20 Michael Higgins Tissue penetrating apparatus
EP2252196A4 (en) 2008-02-21 2013-05-15 Dexcom Inc SYSTEMS AND METHOD FOR PROCESSING, TRANSMITTING AND DISPLAYING SENSOR DATA
JP5427362B2 (ja) * 2008-03-25 2014-02-26 テルモ株式会社 ヘマトクリット値または血液成分濃度の測定方法および測定装置
US20090246075A1 (en) * 2008-03-25 2009-10-01 Health & Life Co., Ltd. Biosensing device
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US8262874B2 (en) * 2008-04-14 2012-09-11 Abbott Diabetes Care Inc. Biosensor coating composition and methods thereof
EP2293719B1 (en) 2008-05-30 2015-09-09 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
US8394637B2 (en) * 2008-06-02 2013-03-12 Roche Diagnostics Operations, Inc. Handheld analyzer for testing a sample
WO2009148624A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Detection meter and mode of operation
EP2299904B1 (en) 2008-06-06 2019-09-11 Intuity Medical, Inc. Medical measurement method
US7922985B2 (en) * 2008-06-24 2011-04-12 Lifescan, Inc. Analyte test strip for accepting diverse sample volumes
US8178313B2 (en) * 2008-06-24 2012-05-15 Lifescan, Inc. Method for determining an analyte in a bodily fluid
US8187658B2 (en) * 2008-06-24 2012-05-29 Lifescan, Inc. Method of manufacturing analyte test strip for accepting diverse sample volumes
US7896703B2 (en) * 2008-07-17 2011-03-01 Abbott Diabetes Care Inc. Strip connectors for measurement devices
US8465977B2 (en) 2008-07-22 2013-06-18 Roche Diagnostics Operations, Inc. Method and apparatus for lighted test strip
US8057586B2 (en) * 2008-07-28 2011-11-15 Multisorb Technologies, Inc. Humidity control for product in a refrigerator
US20110174618A1 (en) * 2008-09-30 2011-07-21 Menai Medical Technologies Limited Sample measurement system
WO2010063304A1 (en) * 2008-12-05 2010-06-10 Egomedical Swiss Ag Test element holding system and personal diagnostic device comprising the same
FI20095063A0 (fi) * 2009-01-26 2009-01-26 Wallac Oy Optinen mittauslaite
US20100189600A1 (en) * 2009-01-29 2010-07-29 3M Innovative Properties Company Monitor for optical detection of organic analytes
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
EP2221608B1 (de) * 2009-02-18 2015-08-12 F. Hoffmann-La Roche AG Testverfahren zur Untersuchung einer Körperflüssigkeit
EP2228658A1 (de) * 2009-03-13 2010-09-15 Roche Diagnostics GmbH Verfahren zur Herstellung eines analytischen Verbrauchsmittels
JP5889182B2 (ja) * 2009-03-30 2016-03-22 スリーエム イノベイティブ プロパティズ カンパニー 検体の検出のための光電子法及びデバイス
CA2758526A1 (en) * 2009-04-15 2010-10-21 Relia Diagnostic Systems, Inc. Diagnostic devices and related methods
US9226701B2 (en) 2009-04-28 2016-01-05 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
US8501111B2 (en) 2009-05-21 2013-08-06 Tom Cheng Xu Small volume and fast acting optical analyte sensor
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
KR101100620B1 (ko) * 2009-06-04 2012-01-03 주식회사 인포피아 재현성 향상을 위한 알고리즘을 사용하는 생체 데이터 측정장치 및 생체 데이터 측정방법
JP5290058B2 (ja) * 2009-06-05 2013-09-18 テルモ株式会社 成分測定装置
EP2473098A4 (en) 2009-08-31 2014-04-09 Abbott Diabetes Care Inc ANALYTICAL SIGNAL PROCESSING APPARATUS AND METHOD
EP2473099A4 (en) 2009-08-31 2015-01-14 Abbott Diabetes Care Inc ANALYTICAL SUBSTANCE MONITORING SYSTEM AND METHODS OF MANAGING ENERGY AND NOISE
US9320461B2 (en) 2009-09-29 2016-04-26 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
CN105825049A (zh) 2009-10-19 2016-08-03 提拉诺斯公司 集成的健康数据采集和分析系统
US20110098590A1 (en) * 2009-10-26 2011-04-28 Pulse Health Llc Methods and apparatuses for detecting analytes
EP2325624A1 (de) * 2009-11-18 2011-05-25 F. Hoffmann-La Roche AG Verfahren und Vorrichtung zur Untersuchung einer Körperflüssigkeit
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
DE102010001032B4 (de) * 2010-01-19 2014-11-20 Merete Management Gmbh Indikationseinrichtung
EP2362207A1 (de) * 2010-01-28 2011-08-31 F. Hoffmann-La Roche AG Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung
US8391940B2 (en) * 2010-02-04 2013-03-05 Lifescan, Inc. Methods and systems to correct for hematocrit effects
GB201005357D0 (en) 2010-03-30 2010-05-12 Menai Medical Technologies Ltd Sampling plate
GB201005359D0 (en) 2010-03-30 2010-05-12 Menai Medical Technologies Ltd Sampling plate
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9008373B2 (en) 2010-05-06 2015-04-14 Charm Sciences, Inc. Device, system and method for transit testing of samples
EP2580589B1 (en) 2010-06-09 2016-08-31 Optiscan Biomedical Corporation Measuring analytes in a fluid sample drawn from a patient
CA2803797A1 (en) 2010-06-25 2011-12-29 Intuity Medical, Inc. Analyte monitoring methods and systems
CN102401796B (zh) * 2010-09-09 2017-02-01 艾博生物医药(杭州)有限公司 一种读取测试载体上化验结果的设备
US9562256B2 (en) 2010-10-23 2017-02-07 Pop Test LLC Devices and formulations for detecting, screening and monitoring levels of certain constituents in bodily fluids and method
RU2013121787A (ru) 2010-10-23 2014-11-27 ПОП ТЕСТ ЭлЭлСи Устройство, состав и способ для обнаружения, изучения и контроля уровней определенных компонентов в жидкостях организма
WO2012058237A1 (en) 2010-10-26 2012-05-03 Abbott Diabetes Care Inc. Analyte measurement devices and systems, and components and methods related thereto
US9713440B2 (en) 2010-12-08 2017-07-25 Abbott Diabetes Care Inc. Modular analyte measurement systems, modular components thereof and related methods
TW201231964A (en) 2011-01-31 2012-08-01 Hmd Biomedical Inc Test strip
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
JP2012215467A (ja) * 2011-03-31 2012-11-08 Fujifilm Corp 生体物質分析装置および生体物質分析方法
EP3575796B1 (en) 2011-04-15 2020-11-11 DexCom, Inc. Advanced analyte sensor calibration and error detection
CA3154143A1 (en) 2011-08-03 2013-02-07 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US20130048530A1 (en) * 2011-08-22 2013-02-28 Chin-Chang Yang Biosensor disposable apparatus
USD680454S1 (en) 2011-10-25 2013-04-23 Abbott Diabetes Care Inc. Analyte meter and strip port
JP6443802B2 (ja) 2011-11-07 2018-12-26 アボット ダイアベティス ケア インコーポレイテッドAbbott Diabetes Care Inc. 分析物モニタリング装置および方法
US20140311227A1 (en) * 2011-12-01 2014-10-23 Modz Oy Portable device for measuring blood samples
CN102520182B (zh) * 2011-12-27 2014-01-15 天津科技大学 一种可视血糖试纸及其制备方法
DE202012101167U1 (de) 2012-03-30 2013-07-01 Seramun Diagnostica Gmbh Vorrichtung zum Bestimmen von Proben in einer Probenvolumenanordnung und Ständer für die Vorrichtung
WO2013156526A1 (de) 2012-04-19 2013-10-24 F. Hoffmann-La Roche Ag Verfahren und vorrichtung zur bestimmung einer analytkonzentration in blut
CN107024474B (zh) 2012-06-22 2020-11-06 霍夫曼-拉罗奇有限公司 用于检测体液中的分析物的方法和器件
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
WO2014051425A1 (en) * 2012-09-28 2014-04-03 Dsm Ip Assets B.V. Test strip reading device and method for reading a test strip
US9395234B2 (en) 2012-12-05 2016-07-19 Cardiocom, Llc Stabilizing base for scale
CN103115919A (zh) * 2012-12-27 2013-05-22 中国科学院过程工程研究所 一种葡萄糖检测试纸
US9121050B2 (en) 2013-03-15 2015-09-01 American Sterilizer Company Non-enzyme based detection method for electronic monitoring of biological indicator
US8858884B2 (en) 2013-03-15 2014-10-14 American Sterilizer Company Coupled enzyme-based method for electronic monitoring of biological indicator
JP5693639B2 (ja) * 2013-04-15 2015-04-01 テルモ株式会社 血糖値測定装置
EP3008454A1 (en) 2013-06-10 2016-04-20 Roche Diagnostics GmbH Method and system for detecting an analyte in a body fluid
US9354194B2 (en) 2013-06-19 2016-05-31 Cilag Gmbh International Orientation independent meter
WO2014205412A1 (en) 2013-06-21 2014-12-24 Intuity Medical, Inc. Analyte monitoring system with audible feedback
US9797916B2 (en) 2014-01-10 2017-10-24 Idexx Laboratories, Inc. Chemical analyzer
US10036709B2 (en) 2014-05-20 2018-07-31 Roche Diabetes Care, Inc. BG meter illuminated test strip
CN106574929B (zh) 2014-07-25 2019-08-09 贝克顿·迪金森公司 分析物测试条试验以及用于其实施的测试条和试剂盒
CN106333695A (zh) * 2015-07-14 2017-01-18 天津亿朋医疗器械有限公司 一种poct检测装置
WO2017056002A1 (en) * 2015-09-29 2017-04-06 Ascensia Diabetes Care Holdings Ag Method and system of using a mobile device for analyte detection
US10436773B2 (en) 2016-01-18 2019-10-08 Jana Care, Inc. Mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening
US11119102B1 (en) 2016-02-16 2021-09-14 Charm Sciences, Inc. Test device, method, and assembly
WO2017188085A1 (ja) * 2016-04-27 2017-11-02 コニカミノルタ株式会社 光分析装置及び光分析方法
CN106053378A (zh) * 2016-07-26 2016-10-26 中国石油化工股份有限公司 在用轧制油皂化值的快速测定装置
US10352922B2 (en) 2017-08-16 2019-07-16 Thermo Finnigan Llc System and method of measuring hematocrit
EP3679343B1 (en) * 2017-09-06 2023-06-07 Clemson University Research Foundation Coupon design for enhanced color sensitivity for colorimetric-based chemical analysis of liquids
CN111246797A (zh) 2017-10-24 2020-06-05 德克斯康公司 预连接分析物传感器
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
CN107727851A (zh) * 2017-11-15 2018-02-23 北京舜雷科技有限公司 一种免疫凝集和胶体金层析试纸条相结合的用于检测hit抗体的系统
WO2019108080A1 (ru) * 2017-12-01 2019-06-06 Общество с ограниченной ответственностью "НСЛ" Многослойная защитная полоска для лазерного перфоратора
DE102018208049A1 (de) * 2018-05-23 2019-11-28 Robert Bosch Gmbh Gerüststruktur zum Zusammenwirken mit einer Bildauswertevorrichtung für zumindest einen mindestens eine optochemische Detektierfläche aufweisenden Träger
CN111077205A (zh) * 2018-10-19 2020-04-28 阿瓦隆·海帕波有限公司 半乳糖快速检测系统及其应用
US11125738B2 (en) 2018-11-06 2021-09-21 Thermo Finnigan Llc Blood sample analysis systems and methods
USD915618S1 (en) * 2019-02-21 2021-04-06 Testcard Ltd Medical test card
USD909602S1 (en) * 2019-02-21 2021-02-02 Testcard Ltd. Medical test card
US11053531B2 (en) 2019-05-31 2021-07-06 Linda Marie Petter Tester paper and methods of use thereof for detecting a bacterial infection
CN110389129B (zh) * 2019-08-01 2022-04-22 四川轻化工大学 用于显示690镍基合金熔敷金属晶界的腐蚀剂及其浸蚀方法
TWI699535B (zh) * 2019-10-09 2020-07-21 林文貴 檢測條之製造方法
CN112557663A (zh) 2019-09-25 2021-03-26 百略医学科技股份有限公司 检测条及检测条的制造方法
US11536732B2 (en) 2020-03-13 2022-12-27 Jana Care, Inc. Devices, systems, and methods for measuring biomarkers in biological fluids
CN112729543B (zh) * 2020-12-18 2023-01-03 上海安杰智创科技股份有限公司 一种光学检测中窄带吸收的背景校正方法、设备及介质
JP1706794S (ja) 2021-06-17 2022-02-03 血糖テストストリップ
CN113624754A (zh) * 2021-08-13 2021-11-09 重庆博士泰生物技术有限公司 尿液草酸含量检测试剂盒及检测方法

Family Cites Families (435)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2369499A (en) 1945-02-13 Apparatus fob measuring rate of
US3127281A (en) * 1964-03-31 Means and method of making multi-test indicator
US2297248A (en) * 1936-08-21 1942-09-29 Rudolph Hans Porous materials and process of making
NL289920A (zh) * 1951-01-28
DE1598067A1 (de) * 1951-01-28 1970-03-26 Boehringer Mannheim Gmbh Verfahren und diagnostische Mittel zur enzymatischen Bestimmung von Glucose
IT568716A (zh) * 1956-02-03
SE173761C1 (zh) * 1956-11-07 1960-12-20
BE563751A (zh) * 1957-01-08
US3092465A (en) 1960-03-25 1963-06-04 Miles Lab Diagnostic test device for blood sugar
NL286850A (zh) * 1961-12-18 1900-01-01
ES310641A1 (es) 1964-03-20 1965-07-01 Boehringer & Soehne Gmbh Procedimiento para la obtencion de un medio de diagnostico para el reconocimiento de los constituyentes de sangre pura
US3804593A (en) * 1964-05-25 1974-04-16 Technicon Instr Automatic analysis apparatus and method
DE1910272U (de) * 1964-11-12 1965-02-18 Boehringer & Soehne Gmbh Teststreifen.
US3298789A (en) * 1964-12-14 1967-01-17 Miles Lab Test article for the detection of glucose
US3298769A (en) * 1964-12-31 1967-01-17 Sylvania Electric Prod Method and apparatus for making electron discharge devices
GB1346301A (en) 1965-06-04 1974-02-06 Adler Auto Precision Ltd Methods for mixing and or dispensing liquids and apparatus therefor
DE1567325C3 (de) * 1965-08-05 1975-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Gewinnung reiner Fructose und Glucose aus Saccharose bzw Saccharosehaitigen Invertzuckern
US3413198A (en) * 1966-06-30 1968-11-26 Calbiochem Reagents and method for assaying biological samples
DE1598153C3 (de) * 1966-11-22 1973-11-22 Boehringer Mannheim Gmbh, 6800 Mannheim Diagnostisches Mittel zum Nach weis der Inhaltsstoffe von Korperflus sigkeiten
US3552925A (en) * 1967-07-13 1971-01-05 Miles Lab Whole blood separation method and test using same
US3552928A (en) * 1967-07-19 1971-01-05 Miles Lab Whole blood separation means and test system using same
US3511608A (en) * 1967-12-14 1970-05-12 Harold P Anderson Multiple layer paper test strip
US3607093A (en) * 1968-02-15 1971-09-21 Schering Corp Devices for testing biological liquids
US3560161A (en) 1968-03-14 1971-02-02 Nasa Automated fluid chemical analyzer
CH482249A (de) 1968-04-19 1969-11-30 Contraves Ag Teilchenzähleinrichtung
US3604815A (en) 1968-04-22 1971-09-14 Miles Lab Reflectance meter
US3506126A (en) * 1968-05-03 1970-04-14 Milton Roy Co Closed recirculating hemodialysis system
US3591480A (en) * 1968-07-15 1971-07-06 Ibm Glucose measuring system
DE1810216B2 (de) * 1968-11-21 1971-12-09 Boehnnger Mannheim GmbH, 6800 Mannheim Duennschichtchromatographiegeraet
US3811840A (en) * 1969-04-01 1974-05-21 Miles Lab Test device for detecting low concentrations of substances in fluids
US3593568A (en) * 1969-04-01 1971-07-20 Bio Dynamics Inc Prothrombin time measuring apparatus with means to start the timer in response to the initial decrement of optical transmissivity
DE1940816C3 (de) * 1969-08-11 1974-01-17 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und diagnostisches Mittel zur enzymatischen Bestimmung von Glucose
BE754658A (fr) * 1969-08-12 1971-02-10 Merck Patent Gmbh Lamelle indicatrice, se composant d'une matiere capillaire impregnee, absorbante et gainee de feuilles
DE1943580B2 (de) * 1969-08-27 1971-08-05 Reagens zur blutzuckerbestimmung
CH513393A (de) * 1969-08-28 1971-09-30 Greiner Electronic Ag Verfahren zur reihenweisen Durchführung chemischer und/oder physikalischer Analysen
US3748044A (en) 1969-09-02 1973-07-24 Abbott Lab Digital chemical analysis apparatus
DE1946137C3 (de) * 1969-09-11 1975-01-02 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Gewinnung von Glycerinkinase aus Mikroorganismen
DE1959410C3 (de) * 1969-11-26 1974-02-28 Boehringer Mannheim Gmbh, 6800 Mannheim Indikator zur Bestimmung der reduzierten Pyridincöenzyme
BE759811A (fr) * 1969-12-04 1971-06-03 Technicon Instr Appareil de determination automatique des vitesses de coagulation, agglutination ou floculation de liquides, et agent renforcateur de reactionutilisable avec cet appareil
US3658480A (en) 1970-04-13 1972-04-25 Bio Data Corp Coagulation timing apparatus, and method
US3690833A (en) 1970-05-04 1972-09-12 Damon Corp Automated fluids analyzer having selectively interrupted flow
US3775595A (en) * 1970-06-12 1973-11-27 Instrumentation Labor Inc Apparatus for processing chemical materials held in container structures
US3718439A (en) * 1970-06-12 1973-02-27 Instrumentation Labor Inc Analytical apparatus
US3703336A (en) * 1970-06-12 1972-11-21 Instrumentation Labor Inc Analysis system employing a plural chamber cuvette structure
US3672845A (en) * 1970-07-28 1972-06-27 Miles Lab Test device for albumin
US3672838A (en) * 1970-09-10 1972-06-27 Sargent Welch Scientific Co Analytical method and apparatus using diffusion across a boundary between liquids
US3663175A (en) * 1970-10-05 1972-05-16 Bio Dynamics Inc Method of determining hemoglobin in blood
US4370983A (en) 1971-01-20 1983-02-01 Lichtenstein Eric Stefan Computer-control medical care system
US3933593A (en) * 1971-02-22 1976-01-20 Beckman Instruments, Inc. Rate sensing batch analysis method
US3791933A (en) * 1971-02-25 1974-02-12 Geomet Rapid methods for assay of enzyme substrates and metabolites
US3709612A (en) 1971-03-10 1973-01-09 Miles Lab Apparatus for measuring reflected light under stabilized light source conditions
US3802843A (en) * 1971-05-28 1974-04-09 American Hospital Supply Corp Fluid testing apparatus
DE2130287C3 (de) * 1971-06-18 1975-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Einrichtung zum Einbringen einer dosierten Fremdflüssigkeitsmenge in einen Flüssigkeitshauptstrom
US3723064A (en) * 1971-07-26 1973-03-27 L Liotta Method and device for determining the concentration of a material in a liquid
US3765841A (en) 1971-08-06 1973-10-16 Beckman Instruments Inc Method and apparatus for chemical analysis
US3795149A (en) * 1971-10-15 1974-03-05 Technicon Instr Method and apparatus for supplying samples for automated analysis
US3950133A (en) * 1971-10-20 1976-04-13 Mallinckrodt, Inc. Reagent formulations for assaying biological specimens and methods of preparing and using same
NL176406C (nl) * 1971-10-27 1985-04-01 Philips Nv Ladingsgekoppelde halfgeleiderinrichting met een halfgeleiderlichaam bevattende een aan een oppervlak grenzende halfgeleiderlaag en middelen om informatie in de vorm van pakketten meerderheidsladingsdragers in te voeren in de halfgeleiderlaag.
DE2158124C3 (de) * 1971-11-24 1975-03-13 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von Polyamidvlies oder -filz als saugfähiger Träger für diagnostische Mittel
US3785772A (en) * 1971-12-08 1974-01-15 Blowitz M Blood analyzer
BE793152A (fr) 1971-12-22 1973-06-21 Union Carbide Corp Procede d'analyse spectrophotometrique
JPS4877104A (zh) * 1972-01-25 1973-10-17
DE2205733C3 (de) * 1972-02-08 1974-07-18 Boehringer Mannheim Gmbh 9-(gamma-Ami nopropyl)-3-aminocarbazol
US3814582A (en) * 1972-03-02 1974-06-04 Beckman Instruments Inc Automated chemical analyser system
US4059405A (en) * 1972-04-11 1977-11-22 Damon Corporation Method and apparatus for analysis of constituent carried in fibrous medium
US3798004A (en) * 1972-04-18 1974-03-19 Ames Yissum Ltd Test device
US3769178A (en) 1972-04-27 1973-10-30 Rothermel Ass Inc Method and apparatus for end point detection in potentiometric titration
JPS4911395A (zh) * 1972-05-15 1974-01-31
US3973189A (en) 1972-05-15 1976-08-03 General Science Corporation Hematology system
DE2229208A1 (de) * 1972-06-15 1974-01-03 Boehringer Mannheim Gmbh Verfahren zur trennung von zuckern
DE2332760C3 (de) 1972-06-30 1982-03-04 Eastman Kodak Co., 14650 Rochester, N.Y. Material für die quantitative spektrophotometrische Analyse einer Flüssigkeit
DE2235152C2 (de) * 1972-07-18 1975-07-10 Boehringer Mannheim Gmbh, 6800 Mannheim Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten
US4180060A (en) * 1972-08-18 1979-12-25 Boehringer Mannheim Gmbh Device for staining biological materials
US3876274A (en) * 1972-09-13 1975-04-08 Elco Corp Receptacles employing high density array of overlapping self-adjustable contacts
US4258159A (en) * 1972-11-24 1981-03-24 Solvay & Cie Process for the polymerization of olefins
DE2329174C2 (de) * 1973-06-07 1975-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur quantitativen Bestimmung von Blutammoniak
US3902052A (en) * 1973-06-11 1975-08-26 Technicon Instr Method and apparatus for the peak monitoring the results of analysis apparatus
US3881992A (en) 1973-07-02 1975-05-06 Wilson Ralston Optical rate measurement method
US3910701A (en) * 1973-07-30 1975-10-07 George R Henderson Method and apparatus for measuring light reflectance absorption and or transmission
US3975398A (en) * 1973-08-01 1976-08-17 Boehringer Mannheim G.M.B.H. 9-Substituted 3-aminocarbazole compounds
US3988208A (en) * 1973-08-01 1976-10-26 Boehringer Mannheim G.M.B.H. 9-Substituted 3-aminocarbazole compounds and test strip indicator compositions
US3992158A (en) * 1973-08-16 1976-11-16 Eastman Kodak Company Integral analytical element
US3926357A (en) 1973-10-09 1975-12-16 Du Pont Process for applying contacts
AR204182A1 (es) * 1973-12-20 1975-11-28 Boehringer Mannheim Gmbh Tira de ensayo para la comprobacion de substancias de actividad peroxidica en los liquidos del cuerpo
US3907503A (en) * 1974-01-21 1975-09-23 Miles Lab Test system
DE2410033C2 (de) * 1974-03-02 1975-09-11 Merck Patent Gmbh, 6100 Darmstadt Isolierung von in lipophilen Lösungsmitteln löslichen Inhaltstoffen wäßriger Lösungen
US3876374A (en) * 1974-03-22 1975-04-08 Technicon Instr Method and apparatus for automated quantitative fluid analysis
US3983005A (en) * 1974-03-25 1976-09-28 Eastman Kodak Company Integral element for the analysis of cholesterol
US3954342A (en) * 1974-03-28 1976-05-04 Jan Boeke Optical device for monitoring clarity of a fluid
US3964870A (en) * 1974-03-29 1976-06-22 Boehringer Mannheim G.M.B.H. Diagnostic composition for the determination of glucose
US3957436A (en) * 1974-04-29 1976-05-18 Kallestad Laboratories, Inc. Resultant color step indicator
US3901657A (en) * 1974-04-29 1975-08-26 Sun Scient Inc Device for testing solutions and body fluids
US4283383A (en) * 1974-05-20 1981-08-11 Technicon Instruments Corporation Analysis of biological fluids
US3919051A (en) * 1974-07-11 1975-11-11 Honeywell Inc Biological analyzer and method
US4015121A (en) * 1974-07-11 1977-03-29 Allca Instruments Co. Ltd. Catalsimeter with time measuring circuitry for determining reactant concentration level
DE2436598C2 (de) * 1974-07-30 1983-04-07 Boehringer Mannheim Gmbh, 6800 Mannheim Stabiler Teststreifen zum Nachweis von Inhaltsstoffen in Flüssigkeiten
US3917453A (en) * 1974-08-16 1975-11-04 Polaroid Corp Method and device for determining the concentration of a substance in a fluid
US3915647A (en) * 1974-08-16 1975-10-28 Polaroid Corp Device for determining the concentration of a substance in a fluid
US3936357A (en) * 1974-08-16 1976-02-03 Polaroid Corporation Method and device for determining the concentration of a substance in a fluid
US3926736A (en) * 1974-08-30 1975-12-16 Calbiochem Enzymatic ethanol assay
GB1508576A (en) 1974-09-17 1978-04-26 Ici Ltd Dispersion of solids in organic solvents
US3958560A (en) * 1974-11-25 1976-05-25 Wayne Front March Non-invasive automatic glucose sensor system
SE7513658L (sv) * 1974-12-06 1976-06-08 Hycel Inc Apparat och metod for kalibrering av kemisk analysator
FR2295419A1 (fr) * 1974-12-21 1976-07-16 Kyoto Daiichi Kagaku Kk Dispositif de mesure de reflectance et structure de papier de test composite faisant l'objet d'une telle mesure
US3973129A (en) * 1975-01-10 1976-08-03 Bell Telephone Laboratories, Incorporated Fluorimetric apparatus and method for analysis of body fluid
US3990849A (en) * 1975-02-07 1976-11-09 Technicon Instruments Corporation Separation of cells from liquid components of blood
CA1048390A (en) * 1975-02-14 1979-02-13 James B. Dugle Method, composition, and device for determining the specific gravity of a liquid
US3989789A (en) 1975-03-03 1976-11-02 De Lorme Marketing Corporation Method for making a non-rigid laminar core
JPS51114985A (en) * 1975-04-01 1976-10-09 Kyoto Daiichi Kagaku:Kk Mothod to analyse urine, etc.
US4040786A (en) * 1975-05-16 1977-08-09 Worthington Biochemical Corporation Chemical analysis method using reaction container
CA1054034A (en) * 1975-06-20 1979-05-08 Barbara J. Bruschi Multilayer analytical element
US4042335A (en) * 1975-07-23 1977-08-16 Eastman Kodak Company Integral element for analysis of liquids
US3960497A (en) * 1975-08-19 1976-06-01 Beckman Instruments, Inc. Chemical analyzer with automatic calibration
US3986833A (en) * 1975-09-08 1976-10-19 Miles Laboratories, Inc. Test composition, device, and method for the detection of peroxidatively active substances
US3979274A (en) * 1975-09-24 1976-09-07 The Yellow Springs Instrument Company, Inc. Membrane for enzyme electrodes
US3971630A (en) * 1975-10-07 1976-07-27 Technicon Instruments Corporation Apparatus and method for batch-type analysis of liquid samples
US3985508A (en) * 1975-10-28 1976-10-12 Melvin Williams Automated chemical analyzer
US4194191A (en) 1975-11-10 1980-03-18 General Electric Company Smoke simulating test apparatus for smoke detectors
US4011046A (en) * 1975-11-12 1977-03-08 Temple University Liquid crystal quantitative analysis method for optically active compounds
US4009615A (en) 1975-12-23 1977-03-01 Ruhl George A Self contained electronic digital thermometer
FR2341865A1 (fr) * 1976-02-19 1977-09-16 Api Labor Support pour le dosage d'activites enzymatiques et procede de dosage a l'aide de ce support
US4128628A (en) 1976-03-12 1978-12-05 University Of Virginia Alumni Patents Foundation Automated immunoassay
US4022577A (en) * 1976-03-12 1977-05-10 The University Of Virginia Automated radioimmunoassay
US4038485A (en) * 1976-03-18 1977-07-26 Miles Laboratories, Inc. Test composition, device, and method
US4050898A (en) * 1976-04-26 1977-09-27 Eastman Kodak Company Integral analytical element
US4057394A (en) * 1976-05-24 1977-11-08 Miles Laboratories, Inc. Test device and method for determining blood hemoglobin
US4101276A (en) 1976-06-02 1978-07-18 Beckman Instruments, Inc. Method and apparatus for signalling the introduction of chemical reaction components into a chemical analyzing system
FR2392378B1 (zh) 1976-06-03 1980-10-31 Commissariat Energie Atomique
US4068169A (en) 1976-09-21 1978-01-10 Hycel, Inc. Method and apparatus for determining hematocrit
DE2650730C2 (de) * 1976-11-05 1979-03-29 Boehringer Mannheim Gmbh, 6800 Mannheim Tauchdialysator
IT1123670B (it) * 1976-11-08 1986-04-30 Sclavo Inst Sieroterapeut Composizione adatta alla determinazione enzimatica del glugosio
US4152390A (en) * 1976-12-17 1979-05-01 Eastman Kodak Company Chemical analyzer
US4224032A (en) * 1976-12-17 1980-09-23 Eastman Kodak Company Method and apparatus for chemical analysis
US4199261A (en) * 1976-12-29 1980-04-22 Smith-Kettlewell Eye Research Foundation Optical intensity meter
US4043756A (en) * 1976-12-29 1977-08-23 Hycel, Inc. Calibration in an automatic chemical testing apparatus
US4095272A (en) 1977-01-11 1978-06-13 Phillips Petroleum Company Automatic turbidimetric titration
CA1095819A (en) * 1977-01-14 1981-02-17 Eastman Kodak Company Element for analysis of liquids
US4069017A (en) * 1977-01-14 1978-01-17 Eastman Kodak Company Colorimetric assay for bilirubin
JPS59779B2 (ja) * 1977-01-20 1984-01-09 株式会社京都第一科学 尿等の分析方法
JPS53148522A (en) * 1977-05-30 1978-12-25 Taitou Fuaizaa Kk Paper diagnostic plate
US4110079A (en) * 1977-06-09 1978-08-29 Eastman Kodak Company Analytical element for clinical analysis
US4098574A (en) * 1977-08-01 1978-07-04 Eastman Kodak Company Glucose detection system free from fluoride-ion interference
US4135883A (en) * 1977-08-29 1979-01-23 Bio-Dynamics Inc. Blood analyzer system
US4283491A (en) * 1977-09-06 1981-08-11 Eastman Kodak Company Analytical elements with improved reagent stability
DE2860548D1 (en) 1977-09-09 1981-04-16 Rank Organisation Ltd An optical sensing instrument
JPS5451893A (en) 1977-09-30 1979-04-24 Sankyo Co Measuring of blood coagulating time
DE2744549C2 (de) 1977-10-04 1984-03-29 Alexander Wiegand Gmbh U. Co Armaturen- U. Manometerfabrik, 8763 Klingenberg Einrichtung zur Überwachung der Dichte eines Gases innerhalb eines Druckbehälters
US4298345A (en) * 1977-11-21 1981-11-03 Damon Corporation Method and apparatus for chemical spot test analysis
US4178153A (en) * 1977-11-21 1979-12-11 Damon Corporation Method and apparatus for chemical spot test analysis
US4219529A (en) * 1977-11-28 1980-08-26 Eastman Kodak Company Incubator for chemical analyzer
US4153668A (en) * 1978-01-03 1979-05-08 Eastman Kodak Company Multi-zone analytical element and method using same
JPS591977B2 (ja) 1978-01-25 1984-01-14 株式会社京都第一科学 呈色試験紙を用いた分析方法
US4176008A (en) * 1978-02-24 1979-11-27 Eastman Kodak Company Method, composition and element for the detection of nitrogen-containing compounds
US4165508A (en) * 1978-02-28 1979-08-21 Beckman Instruments, Inc. Method and apparatus for detecting a peak value of an analog signal
FR2420205A1 (fr) 1978-03-13 1979-10-12 Videocolor Sa Tube a masque pour la television en couleurs
US4226537A (en) * 1978-04-15 1980-10-07 Fisons Limited Analytical centrifuge with improved signal/noise ratio
JPS587332Y2 (ja) * 1978-06-06 1983-02-08 富士写真フイルム株式会社 多層血液化学分析材料
US4257862A (en) * 1978-07-24 1981-03-24 Eastman Kodak Company Chemical analyzer
DD143379A3 (de) 1978-07-25 1980-08-20 Kallies Karl Heinz Indikatorroehrchen zur glukosebestimmung
DE2932973A1 (de) * 1978-08-14 1980-02-28 Fuji Photo Film Co Ltd Integrales mehrschichtiges material fuer die chemische analyse des blutes
US4199260A (en) * 1978-08-21 1980-04-22 Technicon Instruments Corporation Apparatus and method for determining the concentration in a sample
US4250257A (en) 1978-08-24 1981-02-10 Technicon Instruments Corporation Whole blood analyses in porous media
US4230456A (en) * 1978-08-30 1980-10-28 Eastman Kodak Company Element and assay for albumin
US4254083A (en) * 1979-07-23 1981-03-03 Eastman Kodak Company Structural configuration for transport of a liquid drop through an ingress aperture
US4233029A (en) * 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
WO1980001081A1 (fr) 1978-11-15 1980-05-29 Battelle Memorial Institute Procede analytique et moyen de mesure de la quantite d'eau oxygenee en milieu aqueux et de substrats organiques produisant de l'eau oxygenee par oxydation enzymatique
US4274744A (en) 1978-11-21 1981-06-23 Medico Electronic, Inc. Direct reading digital colorimeter
DE2850603A1 (de) * 1978-11-22 1980-06-19 Merck Patent Gmbh Haemolysierloesung und verfahren zur haemolyse von blut
US4211845A (en) * 1978-11-24 1980-07-08 Miles Laboratories, Inc. Glucose indicator and method
IT1100425B (it) 1978-11-29 1985-09-28 Costa Maurizio Dalla Macchina atta ad effettuare il taglio in triangoli di pasta sfogliata a la successiva presa rotazione e distanziamento dei triangoli stessi,per la formatura di croissants brioches e simili
US4258001A (en) * 1978-12-27 1981-03-24 Eastman Kodak Company Element, structure and method for the analysis or transport of liquids
US4273868A (en) 1979-02-23 1981-06-16 Miles Laboratories, Inc. Color stable glucose test
US4288228A (en) * 1979-01-31 1981-09-08 Technicon Instruments Corporation Whole blood analyses and diffusion apparatus therefor
US4274832A (en) * 1979-02-12 1981-06-23 Eastman Kodak Company Analytical element and method for analysis of multiple analytes
US4255788A (en) 1979-03-01 1981-03-10 American National Red Cross Phasing detector for continuous flow systems
US4269938A (en) * 1979-03-08 1981-05-26 Eastman Kodak Company Assay of peroxidatively active materials
DE2910134A1 (de) 1979-03-15 1980-09-25 Boehringer Mannheim Gmbh Diagnostisches mittel zum nachweis von bestandteilen von koerperfluessigkeiten
US4554132A (en) 1979-03-19 1985-11-19 Cem Corporation Analytical apparatus for determining volatiles, solids, and solvent extractables in a sample
JPS55136958A (en) 1979-04-14 1980-10-25 Olympus Optical Co Ltd Automatic analyzer
JPS55136957A (en) 1979-04-14 1980-10-25 Olympus Optical Co Ltd Automatic analyzer
JPS55164356A (en) * 1979-06-08 1980-12-22 Fuji Photo Film Co Ltd Multi-layer analysis sheet for liquid sample analysis
US4272482A (en) * 1979-07-02 1981-06-09 Eastman Kodak Company Metering apparatus
US4325910A (en) 1979-07-11 1982-04-20 Technicraft, Inc. Automated multiple-purpose chemical-analysis apparatus
US4310399A (en) 1979-07-23 1982-01-12 Eastman Kodak Company Liquid transport device containing means for delaying capillary flow
US4261041A (en) * 1979-08-06 1981-04-07 Medtek Corporation Method and apparatus for controlling a microprocessor-based system
DE2934190A1 (de) * 1979-08-23 1981-03-19 Müller, Gerhard, Prof. Dr.-Ing., 7080 Aalen Verfahren und vorrichtung zur molekuelspektroskopie, insbesondere zur bestimmung von stoffwechselprodukten
US4310430A (en) * 1979-09-11 1982-01-12 Terumo Corporation α-Olefin-dialkylmaleate-based liquid separating agent
US4710458A (en) * 1979-09-17 1987-12-01 R. J. Harvey Instrument Corporation Nylon strips for medical assay
US4399099A (en) 1979-09-20 1983-08-16 Buckles Richard G Optical fiber apparatus for quantitative analysis
JPS5647761A (en) 1979-09-27 1981-04-30 Fuji Photo Film Co Ltd Laminated analyzing piece and immunity analyzing method using the same
US4257662A (en) * 1979-10-30 1981-03-24 Marathon Electric Manufacturing Corp. Fuseholder with separate reject spring having integral spreading and collapsing control means
US4238196A (en) * 1979-11-01 1980-12-09 Isolab, Inc. Methods to determine a diagnostic indicator of blood sugar conditions, and, liquid chromatographic columns therefor (cyanide free)
US4318984A (en) 1979-11-13 1982-03-09 Miles Laboratories, Inc. Stabilized composition, test device, and method for detecting the presence of a sugar in a test sample
US4253846A (en) 1979-11-21 1981-03-03 Technicon Instruments Corporation Method and apparatus for automated analysis of fluid samples
US4278439A (en) * 1979-12-17 1981-07-14 Miles Laboratories, Inc. Sensitizers for peroxidative activity tests
US4299916A (en) 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4403984A (en) 1979-12-28 1983-09-13 Biotek, Inc. System for demand-based adminstration of insulin
US4320456A (en) * 1980-01-18 1982-03-16 International Business Machines Corporation Control apparatus for virtual address translation unit
US4366061A (en) 1980-01-23 1982-12-28 Cordis Dow Corp. Automated diaphragm apparatus and method for controlling negative pressure hemodialysis treatment
US4276051A (en) 1980-01-28 1981-06-30 Coulter Electronics, Inc. System and program for chemical reaction observation with a moving photometer
US4303408A (en) 1980-02-05 1981-12-01 Eastman Kodak Company Removal of interferents in analytical assays in a two phase interferent-removal zone
DE3005923A1 (de) 1980-02-16 1981-09-03 Compur-Electronic GmbH, 8000 München Photometrisches verfahren und photometrische vorrichtung zur bestimmung von reaktionsablaeufen
US4303406A (en) 1980-03-14 1981-12-01 The Maytag Company Automatic liquid level control
US4303753A (en) 1980-03-20 1981-12-01 Miles Laboratories, Inc. Method and device for the semiquantitative determination of glucose in aqueous fluids
JPS56155835A (en) 1980-05-02 1981-12-02 Olympus Optical Co Ltd Component analyzing method
JPS56164941A (en) * 1980-05-23 1981-12-18 Anritsu Corp Color tone discriminator
GB2079995B (en) 1980-07-16 1984-07-11 Suwa Seikosha Kk Portable data processing apparatus
JPS6033479B2 (ja) 1980-07-30 1985-08-02 協和醗酵工業株式会社 過酸化水素の定量方法
DE3029579C2 (de) 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut
US4816224A (en) 1980-08-05 1989-03-28 Boehringer Mannheim Gmbh Device for separating plasma or serum from whole blood and analyzing the same
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4300906A (en) 1980-10-06 1981-11-17 Technicon Instruments Corp. Method for the operation of automated analysis apparatus
JPS5767860A (en) 1980-10-15 1982-04-24 Fuji Photo Film Co Ltd Material for multilayer analysis
US4407959A (en) 1980-10-29 1983-10-04 Fuji Electric Co., Ltd. Blood sugar analyzing apparatus
US4668619A (en) 1980-10-30 1987-05-26 Miles Laboratories, Inc. Multilayer homogeneous specific binding assay device
US4430427A (en) 1980-11-04 1984-02-07 Phillips Petroleum Company Red absorbing combination of alcohol oxidase and an azide compound
US4420564A (en) 1980-11-21 1983-12-13 Fuji Electric Company, Ltd. Blood sugar analyzer having fixed enzyme membrane sensor
US4483924A (en) 1980-12-09 1984-11-20 Fuji Electric Company, Ltd. System for controlling a printer in a blood sugar analyzer
US4390621A (en) 1980-12-15 1983-06-28 Miles Laboratories, Inc. Method and device for detecting glucose concentration
US4336330A (en) 1980-12-15 1982-06-22 Miles Laboratories, Inc. Device for detecting glucose concentration
JPS57101761A (en) 1980-12-17 1982-06-24 Konishiroku Photo Ind Co Ltd Analyzing element
DE3174918D1 (en) 1980-12-23 1986-08-14 Boehringer Mannheim Gmbh Hydrophilic latex particles, process for their preparation and their use
GB2090659A (en) * 1981-01-02 1982-07-14 Instrumentation Labor Inc Analytical device
US4302420A (en) 1981-01-09 1981-11-24 Eastman Kodak Company Analyzer featuring a contacting reflectometer
US4318985A (en) 1981-01-29 1982-03-09 Miles Laboratories, Inc. Method and device for detecting glucose concentration
JPS57125847A (en) 1981-01-30 1982-08-05 Konishiroku Photo Ind Co Ltd Analysis element
US4391906A (en) 1981-02-12 1983-07-05 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4340669A (en) * 1981-02-12 1982-07-20 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4391905A (en) 1981-02-12 1983-07-05 Miles Laboratories, Inc. System for the determination of glucose in fluids
JPS57142562A (en) 1981-02-27 1982-09-03 Fuji Photo Film Co Ltd Quantitative analysis film and colorimetric quantitative analysis
US4330299A (en) 1981-03-09 1982-05-18 Evreka, Inc. Article and method for measuring glucose level in body fluids
GB2096314A (en) * 1981-03-26 1982-10-13 Lre Relais & Elektronik Gmbh Apparatus for optoelectric evaluation of test paper strips
JPS57160730A (en) 1981-03-27 1982-10-04 Aisin Seiki Co Ltd Automatic clutch control
JPS57174099A (en) 1981-04-17 1982-10-26 Fuji Photo Film Co Ltd Color indicator composition for detecting hydrogen peroxide and quantitative analytical film having reagent layer containing the same
JPS57197466A (en) * 1981-04-29 1982-12-03 Konishiroku Photo Ind Co Ltd Analysis element
JPS57196153A (en) 1981-05-28 1982-12-02 Konishiroku Photo Ind Co Ltd Analysis element
JPS57208997A (en) 1981-06-17 1982-12-22 Fuji Photo Film Co Ltd Liquid analyzing material for oxidase enzyme reaction system
US4430299A (en) 1981-06-18 1984-02-07 Coulter Electronics, Inc. Apparatus for monitoring chemical reactions
US4390343A (en) 1981-07-06 1983-06-28 Miles Laboratories, Inc. Multilayer analytical element having an impermeable radiation diffusing and blocking layer
US4595562A (en) 1981-07-20 1986-06-17 American Hospital Supply Corporation Loading and transfer assembly for chemical analyzer
ES275136Y (es) 1981-07-20 1984-10-01 American Hospital Supply Corporation Dispositivo de anclaje para peldanos en piezas de hormigon o similares.
JPS5818167A (ja) 1981-07-24 1983-02-02 Fuji Photo Film Co Ltd 分析フイルム及びこれを用いる分析方法
US4363874A (en) 1981-08-07 1982-12-14 Miles Laboratories, Inc. Multilayer analytical element having an impermeable radiation nondiffusing reflecting layer
US4592365A (en) 1981-08-10 1986-06-03 Ivac Corporation Electronic sphygmomanometer
US4361648A (en) 1981-08-13 1982-11-30 Miles Laboratories, Inc. Color fixed chromogenic analytical element
DE3133826A1 (de) 1981-08-27 1983-03-10 Boehringer Mannheim Gmbh, 6800 Mannheim Analyseteststreifen und verfahren zu seiner herstellung
US4420566A (en) * 1982-06-10 1983-12-13 Eastman Kodak Company Method and apparatus for detecting sample fluid on an analysis slide
EP0087466B1 (en) * 1981-09-08 1988-01-20 EASTMAN KODAK COMPANY (a New Jersey corporation) Method and apparatus for detecting sample fluid
DE3138878A1 (de) 1981-09-30 1983-04-14 Boehringer Mannheim Gmbh, 6800 Mannheim Messeinrichtung, insbesondere ulbricht'sche kugel
DE3138879A1 (de) 1981-09-30 1983-04-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur erfassung photometrischer signale und anordnung zur durchfuehrung des verfahrens
US4448207A (en) 1981-11-03 1984-05-15 Vital Metrics, Inc. Medical fluid measuring system
JPS5899752A (ja) 1981-11-04 1983-06-14 Konishiroku Photo Ind Co Ltd 多層分析素子
US4562148A (en) 1981-11-06 1985-12-31 Miles Laboratories, Inc. Analytical element and method for preventing reagent migration
US4458539A (en) 1981-12-15 1984-07-10 Baxter Travenol Laboratories, Inc. Blood fractionation apparatus having collected volume display system
JPS58131565A (ja) 1982-01-14 1983-08-05 Konishiroku Photo Ind Co Ltd 分析素子
US4449538A (en) 1982-01-25 1984-05-22 John Corbitt Medical-electronic body fluid accounting system
JPS58139067A (ja) 1982-02-12 1983-08-18 Fuji Photo Film Co Ltd 液体試料の測定法
US4503555A (en) 1982-04-21 1985-03-05 University Of California Semi-automatic optical scanning apparatus utilizing line integration
US4524446A (en) * 1982-07-13 1985-06-18 Westinghouse Electric Corp. Signal quality monitor for protective relay system
US4518259A (en) 1982-07-26 1985-05-21 Eastman Kodak Company Light guide reflectometer
US4460684A (en) 1982-08-02 1984-07-17 Miles Laboratories, Inc. Ascorbate-resistant broad range glucose test composition, test device and method
JPS5926061A (ja) * 1982-08-02 1984-02-10 Eiken Kagaku Kk 体液中の成分定量用試験片
JP2546981B2 (ja) 1982-09-07 1996-10-23 コニカ株式会社 多層分析素子
JPS5946854A (ja) 1982-09-10 1984-03-16 Fuji Photo Film Co Ltd 多層分析材料
JPS5954962A (ja) 1982-09-22 1984-03-29 Fuji Photo Film Co Ltd 多層分析材料
US4450153A (en) 1982-09-30 1984-05-22 Phillips Petroleum Company Alcohol removal from blood with alcohol oxidase
CA1205731A (en) * 1982-11-01 1986-06-10 Roger C. Phillips Test device and method for measurement of analyte levels in colored aqueous fluids
US4478944A (en) 1982-11-24 1984-10-23 Eastman Kodak Company Analytical element containing a barrier zone and process employing same
US4647432A (en) 1982-11-30 1987-03-03 Japan Tectron Instruments Corporation Tokuyama Soda Kabushiki Kaisha Automatic analysis apparatus
JPS59108942A (ja) * 1982-12-14 1984-06-23 Fuji Photo Film Co Ltd シ−ト状分析要素を用いる定量方法
CA1237645A (en) 1982-12-21 1988-06-07 John H. Fisher Assay technique
DE3247608A1 (de) 1982-12-23 1984-07-05 Boehringer Mannheim Gmbh, 6800 Mannheim Teststreifen
US4459358A (en) 1982-12-29 1984-07-10 Polaroid Corporation Multilayer element for analysis
US4587220A (en) 1983-03-28 1986-05-06 Miles Laboratories, Inc. Ascorbate interference-resistant composition, device and method for the determination of peroxidatively active substances
US4649123A (en) 1983-05-12 1987-03-10 Miles Laboratories, Inc. Ion test means having a hydrophilic carrier matrix
DE3321785A1 (de) 1983-06-16 1984-12-20 Boehringer Mannheim Gmbh, 6800 Mannheim Vorrichtung zum positionieren und festhalten eines teststreifens fuer optisch-medizinische messungen
FR2547838B1 (fr) 1983-06-24 1985-11-29 Alsacienne Constr Mat Tex Dispositif melangeur de fils de trame pour machines a tisser
JPS6010171A (ja) 1983-06-30 1985-01-19 Fuji Photo Film Co Ltd 多層分析要素
US4503385A (en) 1983-07-11 1985-03-05 Becton, Dickinson And Company Apparatus and method for regulating sheath fluid flow in a hydrodynamically focused fluid flow system
US4734360A (en) 1983-07-12 1988-03-29 Lifescan, Inc. Colorimetric ethanol analysis method and test device
US4900666A (en) 1983-07-12 1990-02-13 Lifescan, Inc. Colorimetric ethanol analysis method and test device
US4604579A (en) 1983-07-21 1986-08-05 The Regents Of The University Of California Method and apparatus for enhanced T1 NMR measurements using repetition intervals TR related to one another by integer multiples
JPH0737946B2 (ja) * 1983-08-05 1995-04-26 株式会社京都第一科学 体液成分を測定するとともにその検査データを保存管理する装置
US4552458A (en) * 1983-10-11 1985-11-12 Eastman Kodak Company Compact reflectometer
US4603428A (en) 1983-10-13 1986-07-29 General Electric Company Film-based dual energy radiography
US5183741A (en) 1983-10-13 1993-02-02 Fuji Photo Film Co., Ltd. Integral multilayer element for glucose analysis
JPS6091265A (ja) * 1983-10-25 1985-05-22 Mitsubishi Chem Ind Ltd 血清中の鉄の測定方法
US4637978A (en) * 1983-10-28 1987-01-20 Eastman Kodak Company Assay for analysis of whole blood
US4594327A (en) 1983-11-02 1986-06-10 Syntex (U.S.A.) Inc. Assay method for whole blood samples
CA1226796A (en) * 1983-11-07 1987-09-15 Anand Kumar Reflective particle-containing analytical element
US4714341A (en) 1984-02-23 1987-12-22 Minolta Camera Kabushiki Kaisha Multi-wavelength oximeter having a means for disregarding a poor signal
US4670218A (en) 1984-02-24 1987-06-02 Miles Laboratories, Inc. Ion test means having a porous carrier matrix
DE3407359A1 (de) 1984-02-29 1985-08-29 Bayer Ag, 5090 Leverkusen Testvorrichtung und methode zum nachweis einer komponente einer fluessigen probe
US4532107A (en) 1984-03-26 1985-07-30 Miles Laboratories, Inc. Reagent test device
US4661319A (en) * 1984-04-06 1987-04-28 Boehringer Mannheim Diagnostics, Inc. Blood transfer assembly
US4627014A (en) 1984-04-09 1986-12-02 Eastman Kodak Company Method and apparatus for determination of an analyte and method of calibrating such apparatus
DD247808C2 (de) * 1984-04-09 1989-01-11 Dresden Arzneimittel Teststreifen zur aufnahme von blutzuckertagesprofilen und verfahren zu seiner herstellung
US4547460A (en) 1984-04-16 1985-10-15 Eastman Kodak Company Multizone analytical element and method for analyte determination
DE3583414D1 (de) 1984-04-27 1991-08-14 Fuji Photo Film Co Ltd Bestandteil eines analytischen elements zur analyse von einem festkoerper in einer fluessigen probe.
JPS6196466A (ja) * 1984-10-17 1986-05-15 Fuji Photo Film Co Ltd 全血試料分析用具
DE3587159T2 (de) 1984-04-27 1993-08-19 Fuji Photo Film Co Ltd Analytisches element zur analyse einer vollblutprobe.
US4642286A (en) 1984-05-07 1987-02-10 Moldowan Mervin J Composition and method for ethanol determination
CA1259782A (en) * 1984-05-23 1989-09-26 Masahiko Yamamoto Butterfly valve
JPS60256443A (ja) 1984-05-31 1985-12-18 オムロン株式会社 画像計測装置
US4669878A (en) 1984-06-29 1987-06-02 American Monitor Corporation Automatic monochromator-testing system
CA1260387A (en) * 1984-07-17 1989-09-26 Technicon Instruments Corporation Polymeric single layer analytical element
US4693985A (en) * 1984-08-21 1987-09-15 Pall Corporation Methods of concentrating ligands and active membranes used therefor
GB8421255D0 (en) 1984-08-22 1984-09-26 Chan Y H Computerized music teaching instrument
FR2569478B1 (fr) 1984-08-23 1987-01-09 Guerin Bernard Bandelette d'analyse immunologique et procede pour sa fabrication
US4689202A (en) * 1984-09-11 1987-08-25 Miles Laboratories, Inc. Reagent test strip reading instrument
US4876204A (en) 1984-10-11 1989-10-24 Kabushiki Kaisha Kyoto Daiichi Kagaku Method and apparatus of automatic continuous analysis using analytical implement
DE3439181C2 (de) 1984-10-23 1994-01-20 Lange Gmbh Dr Bruno Verfahren zur photometrischen Bestimmung der Konzentration einer Substanz
US5217691A (en) 1984-11-19 1993-06-08 Miles Inc. Nonenzymatic glucose test
GB8429211D0 (en) 1984-11-19 1984-12-27 Mit Peritronic Ltd Reflectometer
US5116763A (en) 1984-11-19 1992-05-26 Miles Inc. Nonenzymatic glucose test
US4717546A (en) 1984-11-19 1988-01-05 Texas Tech University Health Sciences Center Glucose level measuring apparatus
JPS61124393A (ja) 1984-11-20 1986-06-12 Konishiroku Photo Ind Co Ltd 過酸化水素検出用分析素子
US4791461A (en) * 1984-11-27 1988-12-13 Syntex (U.S.A.) Inc. Portable analyzer
JPS61130859A (ja) * 1984-11-27 1986-06-18 シンテツクス・ダイアグノステイツク・リミテツド・パ−トナ−シツプ ポ−タブルアナライザ−
US4775637A (en) 1984-12-10 1988-10-04 Purtec Limited An immunoassay apparatus having at least two waveguides and method for its use
DE3481644D1 (de) 1984-12-10 1990-04-19 Prutec Ltd Verfahren zum optischen nachweis von parametern von substanzen in einem fluessigen analyt.
US4622207A (en) 1984-12-14 1986-11-11 Miles Laboratories, Inc. Reagent test device having sealed matrix boundaries
JPH0673472B2 (ja) 1985-02-05 1994-09-21 コニカ株式会社 分析素子
JPS61189239A (ja) 1985-02-19 1986-08-22 Mitsui Toatsu Chem Inc ブロモスチレン組成物
JPS61212518A (ja) 1985-03-19 1986-09-20 Nippon Paint Co Ltd 血液凝固促進剤
US4627445A (en) * 1985-04-08 1986-12-09 Garid, Inc. Glucose medical monitoring system
US5279294A (en) * 1985-04-08 1994-01-18 Cascade Medical, Inc. Medical diagnostic system
US4787398A (en) * 1985-04-08 1988-11-29 Garid, Inc. Glucose medical monitoring system
GB8509491D0 (en) 1985-04-12 1985-05-15 Plessey Co Plc Optic waveguide biosensors
GB8509492D0 (en) 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
JPS61245057A (ja) 1985-04-23 1986-10-31 Fuji Photo Film Co Ltd 一体型多層分析要素
US4602995A (en) 1985-05-20 1986-07-29 Technicon Instruments Corporation Liquid level adjusting and filtering device
US4803159A (en) 1985-06-03 1989-02-07 Eastman Kodak Company Analytical element and method for determination of total lacate dehydrogenase
US4647430A (en) 1985-06-20 1987-03-03 Miles Laboratories, Inc. Volume independent test device
US4686479A (en) 1985-07-22 1987-08-11 Young Chung C Apparatus and control kit for analyzing blood sample values including hematocrit
JPH0619351B2 (ja) 1985-07-23 1994-03-16 和光純薬工業株式会社 ラテツクス凝集反応測定装置
US4929561A (en) 1985-08-08 1990-05-29 Regents Of The University Of California Absorption-emission optrode and methods of use thereof
US4618475A (en) 1985-08-30 1986-10-21 Miles Laboratories, Inc. Reagent test device containing hydrophobic barriers
JPS6280640A (ja) 1985-10-04 1987-04-14 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US4839296A (en) 1985-10-18 1989-06-13 Chem-Elec, Inc. Blood plasma test method
GB8526355D0 (en) 1985-10-25 1985-11-27 Alta Diagnostic Machines Ltd Determination of antibody content of blood
DE3543416A1 (de) 1985-12-09 1987-06-11 Hoechst Ag Verfahren zum photometrischen auswerten von farbfeldern auf teststreifen
US4772561A (en) 1985-12-23 1988-09-20 Miles Inc. Test device and method of determining concentration of a sample component
US4731726A (en) 1986-05-19 1988-03-15 Healthware Corporation Patient-operated glucose monitor and diabetes management system
US4962021A (en) 1986-06-20 1990-10-09 Personal Diagnostics, Inc. Analyte determination using gel including a reagent system reacts with analyte to change transmissive property of gel detectable by light beam transmitted through gel by total internal reflectance
US4981779A (en) 1986-06-26 1991-01-01 Becton, Dickinson And Company Apparatus for monitoring glucose
US4803625A (en) 1986-06-30 1989-02-07 Buddy Systems, Inc. Personal health monitor
EP0253371A1 (en) 1986-07-15 1988-01-20 Omron Tateisi Electronics Co. Chemical level measurement device with easy action cover and single control mode selection capability
US4935346A (en) * 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US5059394A (en) * 1986-08-13 1991-10-22 Lifescan, Inc. Analytical device for the automated determination of analytes in fluids
US5049487A (en) * 1986-08-13 1991-09-17 Lifescan, Inc. Automated initiation of timing of reflectance readings
US4913150A (en) 1986-08-18 1990-04-03 Physio-Control Corporation Method and apparatus for the automatic calibration of signals employed in oximetry
US4790979A (en) 1986-08-29 1988-12-13 Technimed Corporation Test strip and fixture
JPH0672845B2 (ja) 1986-09-01 1994-09-14 富士写真フイルム株式会社 分析方法
CA1317206C (en) 1986-09-22 1993-05-04 Takeyuki Kawaguchi Method for detecting a component of a biological system and detection device and kit therefor
US5178831A (en) * 1986-10-08 1993-01-12 Dai Nippon Insatsu Kab Ushiki Kaisha Device for testing body fluids
DE3638654A1 (de) 1986-11-12 1988-05-26 Boehringer Mannheim Gmbh Testtraeger zur analytischen bestimmung eines bestandteils einer koerperfluessigkeit
DE3643516A1 (de) 1986-12-19 1988-06-30 Boehringer Mannheim Gmbh Testtraeger fuer die analytische bestimmung von bestandteilen von koerperfluessigkeiten
US4774192A (en) 1987-01-28 1988-09-27 Technimed Corporation A dry reagent delivery system with membrane having porosity gradient
ES2034186T3 (es) 1987-02-17 1993-04-01 Cmb Foodcan Plc Dispositivo de pruebas analiticas.
US5047206A (en) 1987-03-11 1991-09-10 Wayne State University Reagent test strip
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US4952515A (en) 1987-05-22 1990-08-28 Polymer Technology International Corp. Method of detection using a test strip having a non particulate dialyzed polymer layer
US4814142A (en) 1987-05-22 1989-03-21 Polymer Technology International Corp. Test strip having a non-particulate dialyzed polymer layer
US5128171A (en) 1987-05-22 1992-07-07 Polymer Technology International Method of making a test strip having a dialyzed polymer layer
US4943522A (en) 1987-06-01 1990-07-24 Quidel Lateral flow, non-bibulous membrane assay protocols
US4810470A (en) 1987-06-19 1989-03-07 Miles Inc. Volume independent diagnostic device
CA1310905C (en) * 1987-06-19 1992-12-01 Marvin A. Genshaw Process and device for separating and testing whole blood
US4987085A (en) 1987-06-22 1991-01-22 Chemtrak Inc. Blood filtering metering device
AU1816888A (en) 1987-06-26 1989-01-05 Gerrard Abdool Rayman Device for testing fluids
DE3721237A1 (de) 1987-06-27 1989-01-05 Boehringer Mannheim Gmbh Diagnostischer testtraeger und verfahren zu dessen herstellung
US4824649A (en) 1987-08-31 1989-04-25 Stauffer Chemical Company High viscosity potassium metaphosphate
JPH079069Y2 (ja) 1987-11-24 1995-03-06 オムロン株式会社 生化学測定器のブランク値測定用反射板
US5215716A (en) 1987-12-28 1993-06-01 Fuji Photo Film Co., Ltd. Integral multilayer analytical element
JPH0726959B2 (ja) 1988-01-20 1995-03-29 富士写真フイルム株式会社 全血分析要素
US5206177A (en) 1988-01-21 1993-04-27 Boehringer Mannheim Corporation Apparatus for determining an analyte and method therefor
US5114673A (en) 1988-01-21 1992-05-19 Boehringer Mannheim Corporaton Apparatus for determination of a component in a sample
GB8801807D0 (en) 1988-01-27 1988-02-24 Amersham Int Plc Biological sensors
US5104793A (en) 1988-02-16 1992-04-14 Boehringer Mannheim Corporation Method for determining an analyte in a liquid sample using a zoned test device and an inhibitor for a label used in said method
US5043269A (en) 1988-02-16 1991-08-27 Spyros Theodoropulos Chromogenic substrate to peroxidase enzymes
US4876207A (en) 1988-02-16 1989-10-24 Eastman Kodak Company Compositions for the detection of high levels of hydrogen peroxide
DE3809523A1 (de) 1988-03-22 1989-10-12 Miles Inc Verfahren zur herstellung von poroesen membranen, die damit hergestellten membranen und deren verwendung als traegermatrices in teststreifen
NL8800796A (nl) * 1988-03-29 1989-10-16 X Flow Bv Werkwijze voor de chemische analyse van bestanddelen van een lichaamsvloeistof, alsmede een testinrichting en testpakket voor een dergelijke analyse.
US4949400A (en) * 1988-03-31 1990-08-14 Leveen Harry H Hand held glucose colorimeter device
DE3814370A1 (de) 1988-04-28 1989-11-09 Boehringer Mannheim Gmbh Testtraeger fuer die analyse einer probenfluessigkeit, verfahren zur durchfuehrung einer solchen analyse und herstellungsverfahren
EP0341928A1 (en) 1988-05-10 1989-11-15 AMERSHAM INTERNATIONAL plc Improvements relating to surface plasmon resonance sensors
DE68907519T2 (de) 1988-05-10 1993-10-21 Amersham Int Plc Biosensoren.
GB8811919D0 (en) 1988-05-20 1988-06-22 Amersham Int Plc Biological sensors
GB8813307D0 (en) 1988-06-06 1988-07-13 Amersham Int Plc Biological sensors
ATE148944T1 (de) * 1988-06-09 1997-02-15 Boehringer Mannheim Corp Testvorrichtung mit definiertem volumen
US5152962A (en) 1988-07-22 1992-10-06 Ord Corp. Immunoassay apparatus
US5096809A (en) 1988-07-25 1992-03-17 Pacific Biotech, Inc. Whole blood assays using porous membrane support devices
DE3826057A1 (de) 1988-07-30 1990-02-01 Boehringer Mannheim Gmbh Testtraeger zur analytischen bestimmung eines bestandteils einer fluessigen probe
US5082626A (en) 1988-08-08 1992-01-21 Boehringer Mannheim Gmbh Wedge shaped test strip system useful in analyzing test samples, such as whole blood
US5171688A (en) 1988-08-30 1992-12-15 Cholestech Corporation Self-corrected assay device
JPH0721455B2 (ja) 1988-12-01 1995-03-08 株式会社京都第一科学 液体試料中の特定成分を分析するための用具および方法
US5079174A (en) 1988-12-08 1992-01-07 Boehringer Mannheim Corporation Apparatus for sequential determination of an analyte in a fluid sample
US5106758A (en) 1988-12-12 1992-04-21 Technicon Instruments Corporation Analytical test device and the use thereof
DE3844104A1 (de) 1988-12-28 1990-07-05 Boehringer Mannheim Gmbh Testtraeger-analysesystem
US5252293A (en) 1989-01-17 1993-10-12 Vladimir Drbal Analytical slide with porous filter membrane
US5114350A (en) 1989-03-08 1992-05-19 Cholestech Corporation Controlled-volume assay apparatus
SE466157B (sv) 1989-04-25 1992-01-07 Migrata Uk Ltd Saett att bestaemma glukoshalten hos helblod samt engaangskuvett foer detta
US5149505A (en) 1989-07-18 1992-09-22 Abbott Laboratories Diagnostic testing device
US4976724A (en) 1989-08-25 1990-12-11 Lifescan, Inc. Lancet ejector mechanism
AU640162B2 (en) 1989-08-28 1993-08-19 Lifescan, Inc. Blood separation and analyte detection techniques
US5435970A (en) * 1989-12-18 1995-07-25 Environmental Diagnostics, Inc. Device for analysis for constituents in biological fluids
US5188968A (en) * 1989-12-28 1993-02-23 Olympus Optical Co., Ltd. Method and reaction kit for agglutination detection
JP2618727B2 (ja) 1990-01-19 1997-06-11 富士写真フイルム株式会社 全血中の被検成分の定量方法
US5067093A (en) 1990-01-24 1991-11-19 Eastman Kodak Company Reference reading in an analyzer
US5104619A (en) 1990-01-24 1992-04-14 Gds Technology, Inc. Disposable diagnostic system
DE4005021A1 (de) 1990-02-19 1991-08-22 Boehringer Mannheim Gmbh Testtraeger zur analyse einer probenfluessigkeit
US5110724A (en) 1990-04-02 1992-05-05 Cholestech Corporation Multi-analyte assay device
DE4012216A1 (de) 1990-04-14 1991-10-17 Boehringer Mannheim Gmbh Testtraeger fuer die analyse von fluessigkeiten
US5212060A (en) 1990-04-27 1993-05-18 Genesis Labs, Inc. Dry test strip comprising a dextran barrier for excluding erythrocytes
DE4015590A1 (de) 1990-05-15 1991-11-21 Boehringer Mannheim Gmbh Testtraeger zur bestimmung von ionen
US5187100A (en) 1990-05-29 1993-02-16 Lifescan, Inc. Dispersion to limit penetration of aqueous solutions into a membrane
US5147606A (en) 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5166051A (en) 1990-08-08 1992-11-24 Genesis Labs, Inc. Membranes, membrane overlays for exclusion of erythrocytes, and method for immunoassay of whole blood analytes
US5174963A (en) 1991-01-07 1992-12-29 United Medical Manufacturing Company Blood glucose reflectance meter including a null prompting means and a device for providing a constant brightness light
EP0576536B1 (en) 1991-02-27 2001-12-12 Roche Diagnostics Corporation Method of communicating with microcomputer controlled instruments
US5246858A (en) 1991-02-27 1993-09-21 Boehringer Mannheim Corporation Apparatus and method for analyzing a body fluid
EP0555045B1 (en) * 1992-02-03 1997-10-08 Lifescan, Inc. Improved oxidative coupling dye for spectrophotometric quantitative analysis of analytes
US5344754A (en) * 1993-01-13 1994-09-06 Avocet Medical, Inc. Assay timed by electrical resistance change and test strip
JP3488925B2 (ja) * 1994-09-08 2004-01-19 ライフスキヤン・インコーポレーテツド 条片上標準を備えた分析物検出用の光学読取式条片
US5563031A (en) 1994-09-08 1996-10-08 Lifescan, Inc. Highly stable oxidative coupling dye for spectrophotometric determination of analytes
US5526120A (en) * 1994-09-08 1996-06-11 Lifescan, Inc. Test strip with an asymmetrical end insuring correct insertion for measuring
US5515170A (en) 1994-09-08 1996-05-07 Lifescan, Inc. Analyte detection device having a serpentine passageway for indicator strips
US5758644A (en) * 1995-06-07 1998-06-02 Masimo Corporation Manual and automatic probe calibration
US5753452A (en) * 1996-04-04 1998-05-19 Lifescan, Inc. Reagent test strip for blood glucose determination
IL120587A (en) * 1996-04-04 2000-10-31 Lifescan Inc Reagent test strip for determination of blood glucose
US5962215A (en) 1996-04-05 1999-10-05 Mercury Diagnostics, Inc. Methods for testing the concentration of an analyte in a body fluid
US5885839A (en) * 1997-04-15 1999-03-23 Lxn Corporation Methods of determining initiation and variable end points for measuring a chemical reaction
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
US6562625B2 (en) * 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US6576416B2 (en) * 2001-06-19 2003-06-10 Lifescan, Inc. Analyte measurement device and method of use

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