CN101073682A - 药物输送装置 - Google Patents
药物输送装置 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/14546—Front-loading type injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0266—Shape memory materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8262—Internal energy supply devices connectable to external power source, e.g. connecting to automobile battery through the cigarette lighter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
- A61M5/484—Regulating injection pressure
Abstract
一种注射器状的装置,具有与电动手柄相连接的药物分配顶端。该顶端可以密封预装载有一定量的液体或相变药物,或是空载的并由使用者来装载液体或相变药物。所述电动手柄包括适当的传感器和控制器,用于精确驱动顶端以便将液体或相变药物可控地输送到顶端中。所述手柄可以包含譬如电池的内部电源,或是与外部电源和/或控制单元相连接。
Description
技术领域
本发明总的涉及向眼睛后部输送适用于眼病的药物活性剂,更具体地,涉及一种在可控的后压力和流动条件下用于将精确量的液体或相变药物进行输送的装置。
背景技术
老年黄斑变性(ARMD)是老年人失明的主要原因。它侵袭视力中心并使其模糊,导致难于或者无法进行阅读、驾驶以及其他复杂任务。现行估计,大约40%的75岁以上人群和大约20%的60岁以上人群,均遭受某种程度的黄斑变性。对于“湿型”ARMD这种极易导致失明的类型,新生成的脉络膜血管(CNV)会发生漏液现象并逐渐对视网膜造成损伤。目前已经发展出两种主要的治疗方法:(a)激光凝固治疗(b)使用血管形成抑制剂。
激光凝固治疗可能会对视网膜造成伤害并且当CNV靠近中央凹(fovea)时不实用。此外,随着时间的推移,激光凝固治疗常常会造成复发CNV。
血管形成抑制剂可以口服、眼内注射、眼外眼球筋膜下注射,或是局部灌注。对于眼球筋膜下注射的方式,医生将弯针的顶端在视网膜中区附近外部环绕于眼球而放置,并释放精确量的药物。然而,与眼球筋膜下输送相关的问题在于,药物必须缓慢给药并处于相对较低的压力下,以便药物保留在组织中而不是在针的周围泄漏出。
因此,在眼科领域中,存在对用于向人眼可控地输送药物的改良装置的需求。
发明内容
本发明通过提供这样一种注射器状的装置对现有技术进行改进:该装置具有与电动(motorized)手柄相连接的药物分配顶端。该顶端可以密封预装载有一定量的液体或相变药物,或是空载的并由使用者来装载液体或相变药物。所述电动手柄包括适当的传感器和控制器,用于精确驱动顶端以便将液体或相变药物可控地输送到顶端中。所述手柄可以包含譬如电池的内部电源,或是与外部电源和/或控制单元相连接。
相应地,本发明的一个目的在于,提供一种具有药物分配顶端的注射器状装置。
本发明的另一目的在于,提供一种用于向人眼输送药物、并具有被电动手柄所驱动的药物分配顶端的装置。
本发明的另一目的在于,提供一种药物输送装置,其中待输送药物的流率可以得到控制。
本发明的又一目的在于,提供一种药物输送装置,其中待输送药物的量可以得到控制。
通过以下具体描述及附属的权利要求,本发明的这些及其他优点和目的将变得明显。
附图说明
图1是本发明第一实施例的药物输送装置的放大示意图。
图2是本发明第二实施例的药物输送装置的放大示意图。
具体实施方式
如图1中最佳显示地,本发明的药物输送装置10主要包括顶端12和手柄14。顶端12大体包括输送插管或注射针16和本体18。注射针16可以是任何适当尺寸的常规构造注射针。本体18的结构与标准皮下注射器大致相类似,譬如为圆柱和圆筒形,并由玻璃、金属或适宜的塑料制成。本体18的尺寸和外形适于容纳适当量的液体或相变药物。手柄14的尺寸和外形与本体18大致相类似,譬如为圆柱形,并具有适于允许顶端12与手柄14机械相连的远端20。手柄14包括驱动机构22,其具备相关的驱动器电子元件24以推动本体18中的柱塞21,从而将包含于本体18中的液体或相变药物挤出注射针16。适宜的驱动机构譬如包括本领域公知的压电式线性马达(美国专利No.6,940,209中所描述,Henderson),并可以从譬如New ScaleTechnologies Inc(Victor,纽约)的来源获得。对于图1中所示的实施例,用于驱动器22和控制电子元件24的电力从电源26得以提供,譬如位于手柄14内部的电池。上述构造允许了柱塞21非常精确和可控的运动。此外,电子元件24可以配备反馈机构,该反馈机构对反抗药物挤出注射针16的反压力进行感测,并且电子元件24适当调节马达22的速度和方向。
如图2中最佳显示地,本发明的药物输送装置110还可以大体包括顶端112和手柄114。顶端112大体包括输送插管或注射针116和本体118。注射针116可以是任何适当尺寸的常规构造注射针。本体118的结构与标准皮下注射器大致相类似,譬如为圆柱和圆筒形,并由玻璃、金属或适宜的塑料制成。本体118的尺寸和外形适于容纳适当量的液体或相变药物。手柄114的尺寸和外形与本体118大致相类似,譬如为圆柱形,并具有适于允许顶端112与手柄114机械相连的远端120。手柄114包括驱动机构122,其具备相关的驱动器电子元件124以推动本体118中的柱塞121,从而将包含于本体118中的液体或相变药物挤出注射针116。对于图2中所示的实施例,控制电子元件124处于手柄114的外部,并且电力和控制信号通过电缆128提供给驱动机构122。用于驱动器122和电子元件124的电力从外部电源126通过电缆128得以提供。上述构造允许得到较小的手柄114。
本说明仅仅用作解释和说明。相关领域的技术人员显然可知,在不偏离其范围或主旨的情况下,可以对于此描述的本发明作出改变和修改。
Claims (6)
1.一种药物输送装置,包括:
a)手柄;
b)具有本体的顶端,该本体可移除地连接于所述手柄;
c)插管,其大体与所述手柄相对地布置在所述本体上;
d)布置在所述顶端本体中的柱塞;以及
e)布置在所述手柄中的驱动机构,该驱动机构在顶端与手柄相连时提供所述柱塞的运动。
2.如权利要求1的药物输送装置,其中所述驱动机构包括压电式线性马达。
3.如权利要求1的药物输送装置,其中所述手柄还包括用于所述驱动机构的内部电源。
4.如权利要求1的药物输送装置,其中所述手柄还包括用于所述驱动机构的内部控制电子元件。
5.如权利要求1的药物输送装置,进一步包括用于所述驱动机构的外部控制电子元件。
6.如权利要求1的药物输送装置,其中所述手柄还包括用于所述驱动机构的外部电源。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/435,906 | 2006-05-17 | ||
US11/435,906 US20070270750A1 (en) | 2006-05-17 | 2006-05-17 | Drug delivery device |
Publications (1)
Publication Number | Publication Date |
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CN101073682A true CN101073682A (zh) | 2007-11-21 |
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ID=38420664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNA200710104927XA Pending CN101073682A (zh) | 2006-05-17 | 2007-05-17 | 药物输送装置 |
Country Status (12)
Country | Link |
---|---|
US (7) | US20070270750A1 (zh) |
EP (1) | EP1857130A1 (zh) |
JP (1) | JP2007307376A (zh) |
KR (1) | KR20070111394A (zh) |
CN (1) | CN101073682A (zh) |
AR (1) | AR061002A1 (zh) |
AU (1) | AU2007202216A1 (zh) |
BR (1) | BRPI0702340A (zh) |
CA (1) | CA2588519A1 (zh) |
IL (1) | IL183295A0 (zh) |
MX (1) | MX2007005846A (zh) |
TW (1) | TW200744558A (zh) |
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CN101574550B (zh) * | 2008-05-06 | 2013-02-13 | 德昌电机(深圳)有限公司 | 注射装置 |
CN109069758A (zh) * | 2015-11-27 | 2018-12-21 | 赛诺菲-安万特德国有限公司 | 具有允许电磁场感应的保护帽的注射装置 |
CN111712229A (zh) * | 2017-09-15 | 2020-09-25 | 奥叙拉尔有限公司 | 眼科递送装置 |
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SI2600930T1 (sl) * | 2010-08-05 | 2021-08-31 | Forsight Vision4, Inc. | Injekcijska naprava za dajanje zdravila |
CN103209664A (zh) * | 2010-08-05 | 2013-07-17 | 弗赛特影像4股份有限公司 | 可植入的治疗装置 |
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KR101092074B1 (ko) * | 2011-02-22 | 2011-12-12 | 문창수 | 마취용 주사기 |
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- 2007-05-16 MX MX2007005846A patent/MX2007005846A/es not_active Application Discontinuation
- 2007-05-16 TW TW096117365A patent/TW200744558A/zh unknown
- 2007-05-17 JP JP2007131544A patent/JP2007307376A/ja active Pending
- 2007-05-17 KR KR1020070048065A patent/KR20070111394A/ko not_active Application Discontinuation
- 2007-05-17 AU AU2007202216A patent/AU2007202216A1/en not_active Abandoned
- 2007-05-17 CN CNA200710104927XA patent/CN101073682A/zh active Pending
- 2007-05-17 IL IL183295A patent/IL183295A0/en unknown
- 2007-05-17 AR ARP070102129A patent/AR061002A1/es unknown
- 2007-06-14 US US11/762,844 patent/US7762981B2/en not_active Expired - Fee Related
- 2007-07-13 US US11/777,408 patent/US8821440B2/en not_active Expired - Fee Related
- 2007-08-03 US US11/833,668 patent/US7887517B2/en not_active Expired - Fee Related
- 2007-08-03 US US11/833,471 patent/US20080021412A1/en not_active Abandoned
- 2007-08-03 US US11/833,518 patent/US20080021419A1/en not_active Abandoned
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2008
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Cited By (5)
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CN101574550B (zh) * | 2008-05-06 | 2013-02-13 | 德昌电机(深圳)有限公司 | 注射装置 |
CN109069758A (zh) * | 2015-11-27 | 2018-12-21 | 赛诺菲-安万特德国有限公司 | 具有允许电磁场感应的保护帽的注射装置 |
US10869969B2 (en) | 2015-11-27 | 2020-12-22 | Sanofi-Aventis Deutschland Gmbh | Injection device with protective cap allowing electromagnetic field induction |
CN109069758B (zh) * | 2015-11-27 | 2021-11-26 | 赛诺菲-安万特德国有限公司 | 具有允许电磁场感应的保护帽的注射装置 |
CN111712229A (zh) * | 2017-09-15 | 2020-09-25 | 奥叙拉尔有限公司 | 眼科递送装置 |
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US20080015545A1 (en) | 2008-01-17 |
US8821440B2 (en) | 2014-09-02 |
US20080021412A1 (en) | 2008-01-24 |
US20080021419A1 (en) | 2008-01-24 |
KR20070111394A (ko) | 2007-11-21 |
US7887517B2 (en) | 2011-02-15 |
AU2007202216A1 (en) | 2007-12-06 |
IL183295A0 (en) | 2007-12-03 |
US20080097311A1 (en) | 2008-04-24 |
JP2007307376A (ja) | 2007-11-29 |
TW200744558A (en) | 2007-12-16 |
US20080021413A1 (en) | 2008-01-24 |
EP1857130A1 (en) | 2007-11-21 |
CA2588519A1 (en) | 2007-11-17 |
US20080197035A1 (en) | 2008-08-21 |
US7762981B2 (en) | 2010-07-27 |
US20070270750A1 (en) | 2007-11-22 |
AR061002A1 (es) | 2008-07-30 |
BRPI0702340A (pt) | 2008-01-15 |
MX2007005846A (es) | 2008-12-01 |
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