CN101073682A - 药物输送装置 - Google Patents

药物输送装置 Download PDF

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CN101073682A
CN101073682A CNA200710104927XA CN200710104927A CN101073682A CN 101073682 A CN101073682 A CN 101073682A CN A200710104927X A CNA200710104927X A CN A200710104927XA CN 200710104927 A CN200710104927 A CN 200710104927A CN 101073682 A CN101073682 A CN 101073682A
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driving mechanism
delivery device
liquid
medicine
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B·达凯
M·A·齐卡
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Novartis AG
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Alcon Universal Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266—Shape memory materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8262—Internal energy supply devices connectable to external power source, e.g. connecting to automobile battery through the cigarette lighter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
    • A61M5/484—Regulating injection pressure

Abstract

一种注射器状的装置，具有与电动手柄相连接的药物分配顶端。该顶端可以密封预装载有一定量的液体或相变药物，或是空载的并由使用者来装载液体或相变药物。所述电动手柄包括适当的传感器和控制器，用于精确驱动顶端以便将液体或相变药物可控地输送到顶端中。所述手柄可以包含譬如电池的内部电源，或是与外部电源和/或控制单元相连接。

Description

药物输送装置
技术领域
本发明总的涉及向眼睛后部输送适用于眼病的药物活性剂，更具体地，涉及一种在可控的后压力和流动条件下用于将精确量的液体或相变药物进行输送的装置。
背景技术
老年黄斑变性(ARMD)是老年人失明的主要原因。它侵袭视力中心并使其模糊，导致难于或者无法进行阅读、驾驶以及其他复杂任务。现行估计，大约40％的75岁以上人群和大约20％的60岁以上人群，均遭受某种程度的黄斑变性。对于“湿型”ARMD这种极易导致失明的类型，新生成的脉络膜血管(CNV)会发生漏液现象并逐渐对视网膜造成损伤。目前已经发展出两种主要的治疗方法：(a)激光凝固治疗(b)使用血管形成抑制剂。
激光凝固治疗可能会对视网膜造成伤害并且当CNV靠近中央凹(fovea)时不实用。此外，随着时间的推移，激光凝固治疗常常会造成复发CNV。
血管形成抑制剂可以口服、眼内注射、眼外眼球筋膜下注射，或是局部灌注。对于眼球筋膜下注射的方式，医生将弯针的顶端在视网膜中区附近外部环绕于眼球而放置，并释放精确量的药物。然而，与眼球筋膜下输送相关的问题在于，药物必须缓慢给药并处于相对较低的压力下，以便药物保留在组织中而不是在针的周围泄漏出。
因此，在眼科领域中，存在对用于向人眼可控地输送药物的改良装置的需求。
发明内容
本发明通过提供这样一种注射器状的装置对现有技术进行改进：该装置具有与电动(motorized)手柄相连接的药物分配顶端。该顶端可以密封预装载有一定量的液体或相变药物，或是空载的并由使用者来装载液体或相变药物。所述电动手柄包括适当的传感器和控制器，用于精确驱动顶端以便将液体或相变药物可控地输送到顶端中。所述手柄可以包含譬如电池的内部电源，或是与外部电源和/或控制单元相连接。
相应地，本发明的一个目的在于，提供一种具有药物分配顶端的注射器状装置。
本发明的另一目的在于，提供一种用于向人眼输送药物、并具有被电动手柄所驱动的药物分配顶端的装置。
本发明的另一目的在于，提供一种药物输送装置，其中待输送药物的流率可以得到控制。
本发明的又一目的在于，提供一种药物输送装置，其中待输送药物的量可以得到控制。
通过以下具体描述及附属的权利要求，本发明的这些及其他优点和目的将变得明显。
附图说明
图1是本发明第一实施例的药物输送装置的放大示意图。
图2是本发明第二实施例的药物输送装置的放大示意图。
具体实施方式
如图1中最佳显示地，本发明的药物输送装置10主要包括顶端12和手柄14。顶端12大体包括输送插管或注射针16和本体18。注射针16可以是任何适当尺寸的常规构造注射针。本体18的结构与标准皮下注射器大致相类似，譬如为圆柱和圆筒形，并由玻璃、金属或适宜的塑料制成。本体18的尺寸和外形适于容纳适当量的液体或相变药物。手柄14的尺寸和外形与本体18大致相类似，譬如为圆柱形，并具有适于允许顶端12与手柄14机械相连的远端20。手柄14包括驱动机构22，其具备相关的驱动器电子元件24以推动本体18中的柱塞21，从而将包含于本体18中的液体或相变药物挤出注射针16。适宜的驱动机构譬如包括本领域公知的压电式线性马达(美国专利No.6,940,209中所描述，Henderson)，并可以从譬如New ScaleTechnologies Inc(Victor，纽约)的来源获得。对于图1中所示的实施例，用于驱动器22和控制电子元件24的电力从电源26得以提供，譬如位于手柄14内部的电池。上述构造允许了柱塞21非常精确和可控的运动。此外，电子元件24可以配备反馈机构，该反馈机构对反抗药物挤出注射针16的反压力进行感测，并且电子元件24适当调节马达22的速度和方向。
如图2中最佳显示地，本发明的药物输送装置110还可以大体包括顶端112和手柄114。顶端112大体包括输送插管或注射针116和本体118。注射针116可以是任何适当尺寸的常规构造注射针。本体118的结构与标准皮下注射器大致相类似，譬如为圆柱和圆筒形，并由玻璃、金属或适宜的塑料制成。本体118的尺寸和外形适于容纳适当量的液体或相变药物。手柄114的尺寸和外形与本体118大致相类似，譬如为圆柱形，并具有适于允许顶端112与手柄114机械相连的远端120。手柄114包括驱动机构122，其具备相关的驱动器电子元件124以推动本体118中的柱塞121，从而将包含于本体118中的液体或相变药物挤出注射针116。对于图2中所示的实施例，控制电子元件124处于手柄114的外部，并且电力和控制信号通过电缆128提供给驱动机构122。用于驱动器122和电子元件124的电力从外部电源126通过电缆128得以提供。上述构造允许得到较小的手柄114。
本说明仅仅用作解释和说明。相关领域的技术人员显然可知，在不偏离其范围或主旨的情况下，可以对于此描述的本发明作出改变和修改。

Claims (6)

1.一种药物输送装置，包括：
a)手柄；
b)具有本体的顶端，该本体可移除地连接于所述手柄；
c)插管，其大体与所述手柄相对地布置在所述本体上；
d)布置在所述顶端本体中的柱塞；以及
e)布置在所述手柄中的驱动机构，该驱动机构在顶端与手柄相连时提供所述柱塞的运动。
2.如权利要求1的药物输送装置，其中所述驱动机构包括压电式线性马达。
3.如权利要求1的药物输送装置，其中所述手柄还包括用于所述驱动机构的内部电源。
4.如权利要求1的药物输送装置，其中所述手柄还包括用于所述驱动机构的内部控制电子元件。
5.如权利要求1的药物输送装置，进一步包括用于所述驱动机构的外部控制电子元件。
6.如权利要求1的药物输送装置，其中所述手柄还包括用于所述驱动机构的外部电源。
CNA200710104927XA 2006-05-17 2007-05-17 药物输送装置 Pending CN101073682A (zh)

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US11/435,906 US20070270750A1 (en) 2006-05-17 2006-05-17 Drug delivery device
US11/435,906 2006-05-17

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EP (1) EP1857130A1 (zh)
JP (1) JP2007307376A (zh)
KR (1) KR20070111394A (zh)
CN (1) CN101073682A (zh)
AR (1) AR061002A1 (zh)
AU (1) AU2007202216A1 (zh)
BR (1) BRPI0702340A (zh)
CA (1) CA2588519A1 (zh)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101574550B (zh) * 2008-05-06 2013-02-13 德昌电机(深圳)有限公司 注射装置
CN109069758A (zh) * 2015-11-27 2018-12-21 赛诺菲-安万特德国有限公司 具有允许电磁场感应的保护帽的注射装置
CN111712229A (zh) * 2017-09-15 2020-09-25 奥叙拉尔有限公司 眼科递送装置

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US9486581B2 (en) * 2002-09-11 2016-11-08 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
GB0418389D0 (en) * 2004-08-18 2004-09-22 Liversidge Barry P Injection apparatus
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
US20070270744A1 (en) * 2006-05-17 2007-11-22 Bruno Dacquay Limited Reuse Assembly For Ophthalmic Injection Device
US20070270750A1 (en) * 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
US7887521B2 (en) 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US20080281292A1 (en) * 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US9022970B2 (en) * 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US20090104945A1 (en) * 2007-10-17 2009-04-23 Sony Ericsson Mobile Communications Ab handsfree cable for use with an electronic device
CA2705239C (en) 2007-11-08 2018-09-25 Alimera Sciences, Inc. Ocular implantation device
US20090227979A1 (en) * 2008-03-07 2009-09-10 Sanchez Jr Robert J Drug Level Sensor for Injection Device
GB0805521D0 (en) * 2008-03-27 2008-04-30 The Technology Partnership Plc Dispensing system
CA3045436A1 (en) 2009-01-29 2010-08-05 Forsight Vision4, Inc. Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8632511B2 (en) 2009-05-06 2014-01-21 Alcon Research, Ltd. Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
CA2736841C (en) 2010-04-15 2014-02-18 Teneo Innovations Inc. Device and electronic controller for syringe piston control
EP2600876B1 (en) 2010-08-05 2015-04-29 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
PL2600930T3 (pl) 2010-08-05 2021-09-06 Forsight Vision4, Inc. Urządzenie wstrzykujące do dostarczania leku
HRP20211909T1 (hr) * 2010-08-05 2022-03-18 Forsight Vision4, Inc. Uređaj za liječenja oka
WO2012068549A2 (en) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
KR101092074B1 (ko) * 2011-02-22 2011-12-12 문창수 마취용 주사기
JP6038124B2 (ja) * 2011-05-06 2016-12-07 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 異なる断面を備えたロックアウト部材
GB2490721B (en) * 2011-05-12 2017-03-01 Owen Mumford Ltd Injection devices
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
WO2013016363A2 (en) * 2011-07-25 2013-01-31 Tandem Diabetes Care, Inc. Multi-reservoir infusion pump systems and methods
LT2755600T (lt) 2011-09-16 2021-04-26 Forsight Vision4, Inc. Skysčio pakeitimo aparatas
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
CA2896708A1 (en) 2012-12-27 2014-07-03 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
WO2014152959A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
AU2014241163B2 (en) 2013-03-28 2018-09-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
EP2810675A1 (en) * 2013-06-04 2014-12-10 Bioftalmik, S.L. Injector for intraocular injection
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CA2957548A1 (en) 2014-08-08 2016-02-11 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
CA2963563C (en) 2014-11-18 2021-03-09 Eli Lilly And Company Thermal locking mechanism for a medication delivery device
KR101789687B1 (ko) * 2015-06-12 2017-10-25 서울대학교산학협력단 글루코오스 조절 시스템, 상기 글루코오스 조절 시스템의 형성 방법, 및 상기 글루코오스 조절 시스템을 이용한 글루코오스 조절 방법
WO2016200104A1 (ko) * 2015-06-12 2016-12-15 서울대학교산학협력단 바이오 센서 및 그 형성 방법과 글루코오스 조절 시스템, 상기 글루코오스 조절 시스템의 형성 방법, 및 상기 글루코오스 조절 시스템을 이용한 글루코오스 조절 방법
US10279107B2 (en) 2015-08-20 2019-05-07 Tandem Diabetes Care, Inc. Drive mechanism for infusion pump
JP6456550B2 (ja) 2015-09-01 2019-01-23 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 体の部位の医療像データを表示するための装置
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US10182939B2 (en) 2015-09-16 2019-01-22 Novartis Ag Hydraulic injector and methods for intra-ocular lens insertion
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
BR112018010063A2 (pt) 2015-11-20 2018-11-13 Forsight Vision4 Inc estruturas porosas para dispositivos de administração de medicamento de liberação estendida
US10946141B2 (en) * 2016-03-14 2021-03-16 Virchow Biotech Pvt. Ltd. Sterile protective cover comprising a device for opthalmic delivery
EP3442479A1 (en) 2016-04-20 2019-02-20 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
USD821572S1 (en) * 2016-06-20 2018-06-26 Medimmune, Llc Drug delivery implement with translucent housing
USD822199S1 (en) * 2016-06-22 2018-07-03 Medimmune, Llc Drug delivery implement
WO2018136413A2 (en) 2017-01-17 2018-07-26 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
WO2019152908A1 (en) 2018-02-05 2019-08-08 Tandem Diabetes Care, Inc. Methods and systems for detecting infusion pump conditions
US11929160B2 (en) 2018-07-16 2024-03-12 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
CN111956905A (zh) * 2020-07-23 2020-11-20 中国人民解放军空军军医大学 增生性瘢痕局部注射装置

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US39253A (en) * 1863-07-14 Improved hinged collar for lamps
US133155A (en) * 1872-11-19 Improvement in portable cooking apparatus
US177137A (en) * 1876-05-09 Improvement in devices for starting pendulum-clocks
US125665A (en) * 1872-04-16 Improvement in brakes for railway cars
US52761A (en) * 1866-02-20 Improvement in telegraph-insulators
US210200A (en) * 1878-11-26 Improvement in machines for cutting escutcheons
US176720A (en) * 1876-04-25 Improvement in processes for preserving eggs
US47250A (en) * 1865-04-11 carteb
US1252614A (en) * 1917-04-24 1918-01-08 Oscar H Pieper Hot-air syringe.
US3089815A (en) * 1951-10-11 1963-05-14 Lieb Hans Injectable pharmaceutical preparation, and a method of making same
US3466752A (en) * 1967-08-14 1969-09-16 Gilles G Braun Heater stand and cavity injector
GB1175650A (en) * 1968-11-07 1969-12-23 Standard Telephones Cables Ltd Adhesive Applicator
US3608549A (en) * 1970-01-15 1971-09-28 Merrill Edward Wilson Method of administering drugs and capsule therefor
US3858581A (en) * 1973-07-02 1975-01-07 Dean Kamen Medication injection device
US3892537A (en) * 1973-11-28 1975-07-01 Corning Glass Works Preload means for ceramic substrate in exhaust gas purifiers
US4007742A (en) * 1974-06-03 1977-02-15 Surgical Design Corporation. Surgical system for controlling the infusion of fluid to and the evacuation of fluid and material from an operating field
US4030499A (en) * 1974-12-30 1977-06-21 Louis Bucalo Method and apparatus for providing living beings with absorbable implants
US3982537A (en) * 1974-12-30 1976-09-28 Louis Bucalo Dynamic implants and method for implanting the same
US4054138A (en) * 1974-12-30 1977-10-18 Louis Bucalo Implants for acting on living beings
US4003493A (en) 1975-05-27 1977-01-18 Wells Robert A Easy-open container with nondetachable opening member
US4122850A (en) * 1976-06-07 1978-10-31 Louis Bucalo Apparatus for providing living beings with absorbable implants
US4184510A (en) * 1977-03-15 1980-01-22 Fibra-Sonics, Inc. Valued device for controlling vacuum in surgery
US4357136A (en) * 1977-09-09 1982-11-02 Solar Energy Technology, Inc. Method for filling a root canal
US4265618A (en) * 1977-09-09 1981-05-05 Solar Energy Technology, Inc. Electrically heated endodontic syringe for injecting thermoplastic material into a root canal cavity
US4246932A (en) * 1979-10-18 1981-01-27 Burron Medical, Inc. Multiple additive valve assembly
US4795423A (en) * 1980-04-14 1989-01-03 Thomas Jefferson University Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy
JPS58500928A (ja) 1981-05-04 1983-06-09 ソ−ラ−・エナ−ジ−・テクノロジ−・インコ−ポレ−テツド 根管閉塞用注入器
US4392827A (en) * 1981-11-04 1983-07-12 Howard Martin Self-contained root canal heated condenser dental instrument
US4484915A (en) * 1983-03-28 1984-11-27 Tartaglia John A Medical syringe
US4474752A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
ATE95433T1 (de) * 1983-11-15 1993-10-15 Dean L Kamen Behaelteraufbau fuer die auswechselbare verbindung mit einem motorantrieb.
US4648872A (en) * 1983-11-15 1987-03-10 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4582488A (en) * 1984-04-27 1986-04-15 Newman Martin H Dental materials dispenser and applicator
US4704088A (en) * 1984-04-27 1987-11-03 Newman Martin H Dental materials dispenser and applicator
WO1987000029A1 (en) 1985-06-26 1987-01-15 Pitz Richard J Root canal implant-proximity indicative-delivery means
US4713446A (en) * 1985-09-06 1987-12-15 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for ophthalmic use and method of preparation
US4684344A (en) * 1986-04-11 1987-08-04 Nalge Company Electrically powered and heated endodontic syringe
US4992045A (en) * 1987-04-01 1991-02-12 Dentsply Research & Development Corp. Battery powered condenser for root canals
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US5066276A (en) 1988-06-21 1991-11-19 Alcon Laboratories, Inc. Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control
US5120307A (en) * 1988-06-21 1992-06-09 Alcon Laboratories, Inc. Method for injecting viscous fluid into the eye to life retinal membrane
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
US5127522A (en) * 1990-08-02 1992-07-07 Sherwood Medical Company Sharps container with notched insert
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
MX9101786A (es) * 1990-10-30 1992-06-05 Alza Corp Sistema para el suministro de droga y metodo
US5170779A (en) * 1991-01-22 1992-12-15 Ginsberg Irwin A Automated ear cleansing device
US5360413A (en) * 1991-12-06 1994-11-01 Filtertek, Inc. Needleless access device
US5178635A (en) * 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US5368582A (en) * 1992-08-10 1994-11-29 The Schepens Eye Research Institute Method and apparatus for introducing fluid material into an eye
US5336175A (en) * 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
MY113268A (en) 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
US5882338A (en) * 1993-05-04 1999-03-16 Zeneca Limited Syringes and syringe pumps
US5370630A (en) * 1993-11-12 1994-12-06 Smidebush; Michael J. Device for injection of fluidic materials into body tissue
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5522804A (en) * 1994-02-15 1996-06-04 Lynn; Lawrence A. Aspiration, mixing, and injection syringe
US5487725A (en) * 1994-05-12 1996-01-30 Syntec, Inc. Pneumatic vitrectomy for retinal attachment
MX9701394A (es) 1994-08-04 1998-03-31 Quadrant Holdings Cambridge Sistemas de administracion de solidos para la liberacion controlada de moleculas incorporadas en losmismos y metodos para hacer los mismos.
US6221045B1 (en) * 1995-04-20 2001-04-24 Acist Medical Systems, Inc. Angiographic injector system with automatic high/low pressure switching
FR2734485B1 (fr) 1995-05-24 1997-10-10 Biodome Seringue pre-remplie de securite
US5891094A (en) * 1995-09-07 1999-04-06 Innerdyne, Inc. System for direct heating of fluid solution in a hollow body organ and methods
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5582595A (en) * 1995-09-28 1996-12-10 Habley Medical Technology Corporation Aspirating syringe having a plunger guide for a reciprocating plunger assembly
US5984889A (en) * 1996-02-23 1999-11-16 Allergan Sales, Inc. Apparatus and method for delivering viscoelastic material to an eye
US5868710A (en) * 1996-11-22 1999-02-09 Liebel Flarsheim Company Medical fluid injector
US5860949A (en) * 1996-12-20 1999-01-19 Chen; Jen-Yie Volume homeostatic fluid-fluid exchanger
US6139571A (en) * 1997-07-09 2000-10-31 Fuller Research Corporation Heated fluid surgical instrument
US5928663A (en) * 1997-07-30 1999-07-27 Vitrophage, Inc. Intraocular perfluorcarbon compositions and surgical methods of using same
US6079765A (en) * 1997-10-27 2000-06-27 Lear Automotive Dearborn, Inc. Wire holding clip for trim panel
US6352722B1 (en) 1997-12-23 2002-03-05 Quadrant Holdings Cambridge Limited Derivatized carbohydrates, compositions comprised thereof and methods of use thereof
WO1999049818A1 (en) * 1998-03-30 1999-10-07 Marchosky J Alexander Prosthetic system
AU4565299A (en) * 1998-06-15 2000-01-05 Medrad, Inc. Encoding of syringe information
US6024719A (en) * 1998-07-06 2000-02-15 Morris; Robert E Method and apparatus for performing surgery inside the human retina using fluidic internal limiting membrane (ILM) seperation (FILMS)
NZ511545A (en) * 1998-11-10 2003-08-29 Denki Kagaku Kogyo Kk Hyaluronic acid gel, partly soluble in aqueous solution, and easily ejectable from injector and a process for the preparation thereof
JP2002529204A (ja) * 1998-11-13 2002-09-10 エラン・フアルマ・インターナシヨナル・リミテツド 薬品を給送するシステム及び方法
US6372246B1 (en) * 1998-12-16 2002-04-16 Ortho-Mcneil Pharmaceutical, Inc. Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
US6375638B2 (en) * 1999-02-12 2002-04-23 Medtronic Minimed, Inc. Incremental motion pump mechanisms powered by shape memory alloy wire or the like
US6436143B1 (en) * 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
DE19912322A1 (de) * 1999-03-19 2000-09-28 Vetter & Co Apotheker Spritze für medizinische Zwecke
US6290690B1 (en) * 1999-06-21 2001-09-18 Alcon Manufacturing, Ltd. Simultaneous injection and aspiration of viscous fluids in a surgical system
JP4399752B2 (ja) * 1999-07-06 2010-01-20 日本ケミカルリサーチ株式会社 薬剤溶解機構内蔵注射器
AU6519100A (en) 1999-08-05 2001-03-05 Biocardia, Inc. A system and method for delivering thermally sensitive and reverse-thermal gelation matrials
WO2001028473A1 (en) * 1999-10-21 2001-04-26 Alcon Universal Ltd. Sub-tenon drug delivery
US6520930B2 (en) * 1999-11-24 2003-02-18 Medrad, Inc. Injectors, injector systems and injector control
US6270343B1 (en) * 2000-01-07 2001-08-07 Howard Martin Endodontic thermal condenser dental instrument
CA2409711A1 (en) * 2000-05-18 2001-11-22 Dentsply International, Inc. Fluid material dispensing syringe
US6948492B2 (en) * 2000-08-15 2005-09-27 University Of Kentucky Research Foundation Programmable multi-dose intranasal drug delivery device
DK1313415T3 (da) * 2000-08-30 2008-10-13 Univ Johns Hopkins Indretninger til intraokulær lægemiddeladministration
US6585700B1 (en) * 2000-10-05 2003-07-01 Medrad, Inc. Syringe, syringe plunger and attachment mechanism for front loading medical injector
US6691977B2 (en) * 2001-03-16 2004-02-17 Delphi Technologies, Inc. Shape memory alloy fuel injector
GB0114175D0 (en) * 2001-06-11 2001-08-01 Glaxo Group Ltd Medicament dispenser
US6595979B1 (en) * 2001-07-10 2003-07-22 Myocardial Therapeutics, Inc. Methods for sterile aspiration/reinjection of bodily fluid
DE60233811D1 (de) * 2001-09-17 2009-11-05 Durect Corp Vorrichtung und verfahren zur genauen abgabe eines wirkstoffs
US20030055380A1 (en) * 2001-09-19 2003-03-20 Flaherty J. Christopher Plunger for patient infusion device
US7176030B2 (en) * 2002-06-17 2007-02-13 O.R. Solutions, Inc. Method and apparatus for ensuring sterility of disposable medical items used with medical equipment
US7086861B2 (en) * 2002-03-01 2006-08-08 Pitz Richard J System for dispensing viscous materials
US7052251B2 (en) * 2002-04-22 2006-05-30 Medtronic Minimed, Inc. Shape memory alloy wire driven positive displacement micropump with pulsatile output
US6960192B1 (en) * 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
AU2003254092A1 (en) * 2002-07-19 2004-02-09 Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University Localized delivery system for phenstatin using n-isopropylacrylamide
US6929619B2 (en) * 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
US7316676B2 (en) * 2002-08-20 2008-01-08 Gholam A. Peyman Treatment of retinal detachment
WO2004024217A1 (de) * 2002-08-31 2004-03-25 Disetronic Licensing Ag Verabreichungsvorrichtung mit temperatursensor
US20040176720A1 (en) * 2002-08-31 2004-09-09 Urs Kipfer Device for administering a liquid solution of an active substance
US7128727B2 (en) * 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US7186247B2 (en) * 2003-04-04 2007-03-06 Medtronic, Inc. Apparatus and system for delivery of drug therapies
US7364570B2 (en) * 2003-04-16 2008-04-29 Allergan, Inc. Controlled volume injection/aspiration device
US6991457B2 (en) * 2003-05-06 2006-01-31 Aseptico, Inc. Endodontic obturator with disposable cartridge
WO2004112871A1 (en) 2003-06-20 2004-12-29 Allergan, Inc. Needless injectors
US20040267202A1 (en) * 2003-06-26 2004-12-30 Potter Daniel J. Tearable hemostasis valve and splittable sheath
US6940209B2 (en) * 2003-09-08 2005-09-06 New Scale Technologies Ultrasonic lead screw motor
DE10343548B4 (de) * 2003-09-19 2008-03-27 Tecpharma Licensing Ag Vorrichtung für eine dosierte Abgabe eines injizierbaren Produkts
US20050186531A1 (en) * 2004-02-20 2005-08-25 Joshua Friedman Heated compule
US20060047250A1 (en) 2004-08-30 2006-03-02 Hickingbotham Dyson W Fluid delivery device
US7507221B2 (en) * 2004-10-13 2009-03-24 Mallinckrodt Inc. Powerhead of a power injection system
US20070038174A1 (en) * 2005-08-09 2007-02-15 Hopkins Mark A Ophthalmic injector system
US20070060887A1 (en) * 2005-08-22 2007-03-15 Marsh David A Ophthalmic injector
US20070270750A1 (en) * 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101574550B (zh) * 2008-05-06 2013-02-13 德昌电机(深圳)有限公司 注射装置
CN109069758A (zh) * 2015-11-27 2018-12-21 赛诺菲-安万特德国有限公司 具有允许电磁场感应的保护帽的注射装置
US10869969B2 (en) 2015-11-27 2020-12-22 Sanofi-Aventis Deutschland Gmbh Injection device with protective cap allowing electromagnetic field induction
CN109069758B (zh) * 2015-11-27 2021-11-26 赛诺菲-安万特德国有限公司 具有允许电磁场感应的保护帽的注射装置
CN111712229A (zh) * 2017-09-15 2020-09-25 奥叙拉尔有限公司 眼科递送装置

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