CN101045023B - Wire intaking compacting mechanism for self-expanding stent - Google Patents
Wire intaking compacting mechanism for self-expanding stent Download PDFInfo
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- CN101045023B CN101045023B CN2006100252972A CN200610025297A CN101045023B CN 101045023 B CN101045023 B CN 101045023B CN 2006100252972 A CN2006100252972 A CN 2006100252972A CN 200610025297 A CN200610025297 A CN 200610025297A CN 101045023 B CN101045023 B CN 101045023B
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Abstract
A pulled press mechanism for a self-expanding stents is composed of an internal tube for the scaffold arranging system, a locking wire, at least one closed wire pinhole and/or at least one flexible join ring, and a pull thread with a pull ring at its far end for pressing the scaffold. Its application is also disclosed.
Description
Technical field
The various supports that the present invention relates to a kind of implant into body cardiovascular or other luminal organs relate in particular to a kind of wire intaking compacting mechanism for self-expanding stent at the defeated hold-down mechanism of letting slip in the journey.
Background technology
Heart is the most important organ of human body, and heart is divided into left and right sides two parts, and each part comprises atrium and ventricle again.Left atrium and left and right ventricles are separated by interatrial septum and interventricular septum respectively.In heart, there are four cardiac valve, i.e. Tricuspid valve, valve of pulmonary trunk, Bicuspid valve and aortic valve.In the blood of human body cycling mechanism, four cardiac valve play crucial effects.The anoxia blood of body cycling mechanism enters right atrium through caval vein, enter right ventricle by Tricuspid valve then, right ventricle shrinks blood is pressed into pulmonary circulation mechanism by valve of pulmonary trunk, get back to left atrium through the blood behind the lung oxygen saturation through pulmonary vein, arrive left ventricle through Bicuspid valve again, the left ventricle contraction enters aorta with blood by aortic valve and returns to the body cycling mechanism.Left and right sides coronary ostium is arranged under the aortic valve.Close when valve-open when four valvular structures have guaranteed blood along direction, contrary direction, prevented blood reflux and the heart burden that causes.But, because a variety of causes can cause valvular posteriority damage or pathological changes, as rheumatism, atherosclerosis etc.In addition, congenital heart disease such as fallot's disease, postoperative also can produce the cusps of pulmonary valve pathological changes long term.Show as valvular function after the valve pathological changes and lose gradually, cause blood reflux as valvular insufficiency, valvular stenosis causes blood circulation not smooth, or incompetence and narrow the two merger, so that increase the weight of the heart burden, causes cardiac failure.For valvular posteriority damage or pathological changes, traditional Therapeutic Method is out breast, after the cardiac arrest, under the cryotron outer circulation is supported, opens heart and carries out the surgical repair of pathological changes valve or use artificial cardiac valve replacement.Existing Cardiac valve prosthesis divides two big classes: metal mechanical valve prosthesis and biovalve.Biovalve is made after being handled by animal materials such as bovine pericardium, bovine jugular vein lobe, porcine aortic valve.The method of above-mentioned open heart operation, operating time is long, the expense height, wound is big, has a big risk, and metal mechanical valve prosthesis displacement back patient needs long-term anticoagulant therapy, and the material lifetime of biovalve is limited, needs operation more usually.
In order to solve the problem that above-mentioned open heart operation treatment cardiac valve exists, existing now people attempts not doing open heart operation, and adopts percutaneous interventional method or the defeated Cardiac valve prosthesis of putting of Minimally Invasive Surgery.The Cardiac valve prosthesis of prior art comprises balloon-expandable stent valve and self expandable type stent valve.But self expandable type stent valve is provided with the support of a radial deformation, can expand voluntarily after the radial compression.Self expandable type stent valve must carry out the radial compression of protectiveness to stent valve earlier in that intravascular is defeated when being put in the human body, and defeated being put into allows its expansion behind the position again.Therefore must design a cover and compress mechanism, this hold-down mechanism can be made radial compression with it before putting so that fail and put in that stent valve is defeated, fails at stent valve and can remove compression easily after being put into the position, allows the stent valve rapid release expand.
Have following three kinds of different ways that self-expanding stent, self-extending type overlay film frame, self-expanding stent valve are carried out radial compression at present, make it diameter and diminish, Wicresoft easy to use mode is imported in the body.
A), sheath pipe
Self-expanding stent, self-extending type overlay film frame, self-expanding stent valve etc. by radial compression in the thin sheath pipe of a lateral seal.Thin sheath pipe can be by polytetrafluoroethylene (PTFE), perfluoroethylene-propylene making such as (FEP), self-expanding stent radial dilatation under the resilience force effect of itself when the sheath pipe is return.The shortcoming of this method is: 1, the sheath pipe of the defeated place system of existing self-expanding stent and the support under the radial compression are harder, and bendability is poor.2, frictional force is big between the sheath pipe of self-expanding stent and its defeated place system, influences the accurate release of support; Self-expanding stent is under high compression, and the rollback of sheath pipe can run into very big resistance; Move back the resistance of sheath pipe and the support displacement that difficulty also can make the operator locate.3, the thin sheath pipe of lateral seal hinders the guide wire side direction and from inside to outside or from outside to inside passes support under the radial compression, even there is lateral openings to allow seal wire pass through on the sheath pipe, but the seal wire overslaugh sheath pipe that side direction is passed returns, and allows the self-expanding stent can not radial dilatation.4, in order to reach certain mechanical strength, the thin sheath tube thickness minimum of using is 0.20 to 0.30mm at present, makes radial compression lower carriage and induction system increasing diameter add at least 0.40 to 0.60mm.
B), the outer peelable film of support
Comprise:
B1), be permanently affixed at peelable film on the support.At the support external fixation one film that can vertically tear is arranged.But the dyestripping longitudinal opening is a light wall pipe when closing up, its inner support warp-wise compression.But during the strip off of dyestripping longitudinal opening, it is to the support restriction cancellation, and its inner support warp-wise is expanded.But it is identical with stent length to be somebody's turn to do dyestripping, and tearable film length can not change in compression of support warp-wise and process of expansion, flows to side shoot through support but dyestripping can hinder blood.
B2), the outer peelable film of removable support
The bendability of above-mentioned peelable film and radial compression lower carriage has improvement slightly than (a).But still have following shortcoming: 1, peelable film obstruction seal wire side direction from inside to outside or is from outside to inside passed the support under the radial compression; The opening part that the unique position that can pass of side direction seal wire is peelable film, but the side direction seal wire is limited on this unique anglec of rotation.2, be fixed on after peelable film on the support torn, the support radial dilatation, if length shortens after the support radial dilatation, peelable film length is constant but greater than radial dilatation after-poppet length, long film hinders blood flow.3, be fixed on after peelable film on the support torn, support is radial dilatation under self elastic force effect, and circumference increases, on each cross section, the peelable membrane portions that is fixed on the support covers rack outer surface, makes blood side direction inflow collateral blood vessels from here.This hinders support to use at some position, and to coronary ostium, the thoracic aorta overlay film frame is to the carotid artery opening as aortic valve stent, and the ventral aorta overlay film frame is to left and right sides renal artery opening etc.
C), the defeated place system of support cluster
This method has used a kind of softish line 365 degree to be looped around on the support, makes line lower carriage radial compression (referring to Chinese patent 20040054347.0).Compare with preceding two kinds of methods, this is very successful improvement.But still have following shortcoming: 1, support is only online around locating radial compression, if support is longer, the compression of support overall radial is not enough, or needs much to locate around line, and this makes structure become very complicated; Or needing thin sheath pipe further radial compression outside support simultaneously, this makes it lose its open structural advantage.If 2, around line only outside support around, have from the danger of support two end portions slippage; If inside and outside support, shuttle back and forth,, but increase with the frictional force of support just not by the danger of slippage around line.
Summary of the invention
Purpose of the present invention, be to solve the prior art self-expanding stent radial compression is defeated put in the problems referred to above of existence, a kind of wire intaking compacting mechanism for self-expanding stent is provided.
The object of the present invention is achieved like this: a kind of wire intaking compacting mechanism for self-expanding stent is used for compressing this support when self-expanding stent is implanted cardiovascular; Described self-expanding stent be can radial deformation pipe type netted structure, surround a plurality of deformables unit between each netting twine of support, the two ends of support form a plurality of open lines and turn, and support is provided with at least one closed line eye and/or is connected with at least one flexible connection ring; Described self-expanding stent can carry out implanting cardiovascular release after the radial compression with multiple open defeated place system, described defeated place system includes in one pipe and at least one lock thread or also is provided with temporary guy and middle pipe, far away section of interior pipe interts in support and is provided with at least one side opening or also is provided with a lateral guide fiber tube, middle pipe box can slide along interior pipe outside interior pipe, lock silk and temporary guy are arranged in the interior pipe or in the interlayer between the interior Guan Yuzhong pipe, be characterized in, described wire intaking compacting mechanism comprises interior pipe and the lock silk that is used to form defeated place system, the closed line eye of on the support at least one and/or at least one flexible connection ring, and the take-up that is used to compress support, the far-end of take-up is provided with a take-up ring, take-up is after its far-end take-up ring is lived by locking wire lock, same or the different side openings of pipe in passing, at the lock silk, can lock the hold-down mechanism that can separate around knot formation between closed line eye on the support or flexible connection ring and the support outside, the near-end of take-up is drawn and is temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system.
Described wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, on a cross section of support, be provided with a closed line eye or a closed type flexible connecting ring, described take-up is after its far-end take-up ring is lived by locking wire lock, a side opening of pipe in from inside to outside passing, pass closed line eye or closed type flexible connecting ring on the support again, outward around the about Zhou Houzai of support pass from outside to inside same closed line eye or closed type flexible connecting ring and same in the pipe side opening enter interior pipe, lock silk in walking around in the pipe forms the take-up semi-ring, again from inside to outside pass same interior pipe side opening and same closed line eye or closed type flexible connecting ring then and draw, on a cross section of support, can lock the hold-down mechanism that to separate around forming.
Described wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, on a cross section of support, be provided with a closed line eye or a closed type flexible connecting ring, described take-up is after its far-end take-up ring is lived by locking wire lock, a side opening of pipe in from inside to outside passing, pass closed line eye or closed type flexible connecting ring again, around the about Zhou Houzai of support pass from outside to inside same closed line eye or closed type flexible connecting ring and same in the pipe side opening enter interior pipe, lock silk in walking around in the pipe forms the take-up semi-ring, again from inside to outside pass same interior pipe side opening and same closed line eye or closed type flexible connecting ring then, oppositely around the about Zhou Houzai of support pass from outside to inside same closed line eye or closed type flexible connecting ring and same in the pipe side opening enter in the Guan Bingcong pipe draw, on a cross section of support, can lock the hold-down mechanism that can separate around forming.
Described wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, on a cross section of support, link a flexible connection ring compressing structure is arranged, this flexible connection ring compressing structure is around a discontented week of the support under the radial compression, and form two relative free rings, described take-up its far-end take-up ring locked the silk block after, a side opening of pipe in from inside to outside passing, pass first free ring again, turn to second free ring and pass this free ring from outside to inside and same in manage side opening and enter interior pipe, lock silk in walking around in the pipe forms the take-up semi-ring, and then from inside to outside pass same in the free ring of pipe side opening and second, turn again to first free ring and pass this free ring from outside to inside and same in manage side opening enter in the Guan Bingcong pipe draw, on a cross section of support, can lock the hold-down mechanism that can separate around forming.
Described wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, on a cross section of support, link a flexible connection ring compressing structure is arranged, this flexible connection ring compressing structure is around a discontented week of the support under the radial compression, and form two relative free rings, described take-up its far-end take-up ring locked the silk block after, a side opening of pipe in from inside to outside passing, pass first free ring again, turn to second free ring and pass this free ring from outside to inside and same in manage side opening and enter interior pipe, lock silk in walking around in the pipe forms the take-up semi-ring, from inside to outside pass then same in pipe side opening and draw from the interior pipe outside, on a cross section of support, can lock the hold-down mechanism that can separate around forming.
Described wire intaking compacting mechanism is the unidirectional multi-section hold-down mechanism of single take-up, on a plurality of cross sections of support, be respectively equipped with closed line eye or flexible connection ring compressing structure, flexible connection ring compressing structure on the same cross section is around a discontented week of the support under the radial compression, and form two relative free rings, same single take-up is after its far-end take-up ring is locked silk and blocked, successively two relative free rings that pass closed line eye or flexible connection ring compressing structure at the different cross section of support carry out locking can separate around knot, form successive multi-section hold-down mechanism.
Described wire intaking compacting mechanism is the two-way multi-section hold-down mechanism of single take-up, on a plurality of cross sections of support, be respectively equipped with closed line eye or flexible connection ring compressing structure, flexible connection ring compressing structure on the same cross section is around a discontented week of the support under the radial compression, and form two relative free rings, same single take-up is after its far-end take-up ring is locked silk and blocked, earlier to a direction the different cross section of support carry out locking can separate around knot, return along former road then carry out for the second time carrying out locking can separate around knot, form successive multi-section hold-down mechanism, both direction around between the knot section, take-up can be by provisional the blocking once of lock silk.
Described wire intaking compacting mechanism is two unidirectional multi-section hold-down mechanisms of take-up, on a plurality of cross sections of support, be respectively equipped with closed line eye or flexible connection ring compressing structure, flexible connection ring compressing structure on the same cross section is around a discontented week of the support under the radial compression, and form two relative free rings, two take-ups are after its far-end take-up ring is blocked by the lock silk respectively, respectively from the mutually antisymmetric direction of support the different cross section of support carry out locking can separate around knot, form successive multi-section hold-down mechanism.
Described wire intaking compacting mechanism is two two-way multi-section hold-down mechanisms of take-up, on a plurality of cross sections of support, be respectively equipped with closed line eye or flexible connection ring compressing structure, flexible connection ring compressing structure on the same cross section is around a discontented week of the support under the radial compression, and form two relative free rings, two take-ups are after its far-end take-up ring is blocked by the lock silk respectively, respectively from the mutually antisymmetric direction of support earlier to a direction the different cross section of support carry out locking can separate around knot, return along former road then carry out can locking for the second time can separate around knot, form successive multi-section hold-down mechanism, same take-up can be by provisional the blocking once of lock silk between the knot section both direction.
Described flexible connection ring compressing structure is the flexible connection ring of the two free rings of band, the fixedly end ring of this flexible connection ring is pricked and is fixed on the netting twine cross point of support, two free ring is respectively along a discontented week of the support of the circumferential both sides of rack outer surface extended loop under radial compression, and the formation relative status.
Described flexible connection ring compressing structure comprises a plurality of flexible connection rings, wherein the fixedly end ring of two flexible connection rings is pricked and is fixed on the same netting twine cross point of support, the stiff end of all the other flexible connection rings encircles respectively to prick to be fixed on aforementioned netting twine cross point and is on the different netting twines cross point on the same circumference, the free ring of each flexible connection ring is respectively along a discontented week of the support of the circumferential both sides of rack outer surface extended loop under radial compression, the free ring that extends to same direction connects with one another closely continuous in order, and latter two the free ring that extends to both direction forms relative status respectively.
Described wire intaking compacting mechanism also comprises temporary guy and the pipe that is used for forming defeated place system, described take-up its far-end take-up ring by the lock silk between the interior Guan Yuzhong pipe is provisional pass pinning after, from inside to outside pass a closed line eye on the support, laterally the rack surface under radial compression also passes same closed line eye from outside to inside near a week again, draw from the near-end of defeated place system through the interlayer between the interior Guan Yuzhong pipe, the far-end of temporary guy is arranged between the interior Guan Yuzhong pipe and walks around take-up formation two-wire near far-end take-up ring take-up is held to near-end.
Described wire intaking compacting mechanism can be the combination in any of various single cross section hold-down mechanisms and multi-section hold-down mechanism.
Wire intaking compacting mechanism for self-expanding stent of the present invention makes it compared with prior art owing to adopted above technical scheme, has following advantage and characteristics:
A), wire intaking compacting mechanism for self-expanding stent of the present invention, radial compression lower carriage and induction system thereof are very soft, bendability is good especially, makes the support under the compression can be transported to far very crooked vascular site.
B), the wire intaking compacting mechanism thin thickness, make overall radial compression support and the minimizing of induction system cross section down.As use diameter to be the 0.05mm flexible cord, and be 0.20 to 0.30mm to compare with general sheath tube thickness, reduced a lot.The litzendraht wire of the flexible cord that uses for constituting by polyethylene fibre or e politef (ePTFE) fiber or terylene (Dacron), the intensity height, the circular section line can become flat under external force pressure, has further reduced integral diameter.
C), remove wire intaking compacting mechanism, the self-expanding stent radial dilatation is not had or very less friction is only arranged.
D), for the double-layer scaffold of the outer free tongue of band, not under the radial dilatation state, outer free tongue can be expanded at the internal layer support.Outer free tongue plays benchmark (reference) effect, helps support under the radial compression to carry out make progress downstream location and rotate the location around support shaft of support shaft.
E), the closed line eye on the take-up ring of take-up and the support can be at varying level.In not walking, the support take-up in the pipe, do not simplified the structure of interior pipe, the diameter of pipe and compression lower carriage in helping reducing.The horizontal level of the closed line eye of the horizontal level of take-up ring and take-up process has certain distance to proximal direction, makes this system be fit to the support of different length.
F), after twice of the far-end take-up ring of take-up or take-up semi-ring blocked by the lock silk, nearly section can be walked outside interior pipe in the support take-up, has therefore reduced inner tube structure and diameter.
G), wire intaking compacting mechanism for self-expanding stent of the present invention is a kind of open radial compression, delivery system can allow the side direction seal wire pass.Interior Guan Shangke under the support is fixed with the lateral guide fiber tube.Under the support radial compression, seal wire can pass open radial compression supporting structure on any angle, pass support, enters the lateral guide fiber tube under the support.The side direction seal wire can enter collateral blood vessels in advance, plays benchmark (reference) effect, helps support under the radial compression to carry out make progress downstream location and rotate the location around support shaft of support shaft.
H), wire intaking compacting mechanism for self-expanding stent of the present invention is a kind of Open architecture, after the support dilator blood vessel wall, blood can partly flow to collateral blood vessels through carrier openings.
I), wire intaking compacting mechanism for self-expanding stent of the present invention is not subjected to the influence of length variations in support radial compression and the process of expansion.Each the closed line eye that is passed by take-up or the free ring of flexible connection ring all are independently in the radial compression support process, the influence that not changed by stent length.
J), from closed line eye or free can only more by a small margin sliding scale be arranged at rack outer surface around the take-up of tying.Wire intaking compacting mechanism can assemble before art, and the doctor strains take-up in art can radial compression self-expanding stent or stent valve.
K), under the help of closed line eye or free ring, wire intaking compacting mechanism can be support outside around 360 degree almost, also can be around a very little radian.Only need just can encircle the pressure radial compression as the support take-up, thereby reclaim easily support around the very little part of support circumference.
M), nearly section can be walked respectively between the lock silk take-up intracavity or interior pipe and support of interior pipe outside (in the interior pipe support arm) or the support in each take-up, make between them and can not interfere with each other.Guan Suosi take-up chamber in if nearly section is not walked in the support take-up, just avoided and lock thread between interfering with each other, saved the space in interior Guan Suosi take-up chamber, simplified assembling process simultaneously.
Description of drawings
Fig. 1 is first embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention and the perspective view of associated fitting thereof;
Fig. 2 is second embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention and the perspective view of associated fitting thereof;
Fig. 3 is the 3rd embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention and the perspective view of associated fitting thereof;
Fig. 4 is the 4th embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention and the perspective view of associated fitting thereof;
Fig. 5 is the structural representation of facing of the 5th embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention and associated fitting thereof;
Fig. 6 is the structural representation of facing of the 6th embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention and associated fitting thereof;
Fig. 7 is the 7th embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention and the perspective view of associated fitting thereof.
The specific embodiment
Referring to Fig. 1, Fig. 2 Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, wire intaking compacting mechanism for self-expanding stent of the present invention is used for compressing this support when self-expanding stent is implanted cardiovascular.Self-expanding stent can carry out implanting cardiovascular expansion release after the radial compression with multiple open defeated place system.
Among the present invention related self-expanding stent be can radial deformation pipe type netted structure, shown in the label 1 among above-mentioned each figure.Surround a plurality of deformables unit 101 between each netting twine of support, the two ends of support form a plurality of open lines and turn 102, and support is provided with a plurality of closed line eyes 103, form a plurality of cross points 104 between each netting twine of support.Self-expanding stent comprises overlay film frame and stent valve.Can form by the line braiding, also can form by tubing cutting distortion.Support can be monolayer support or the inside and outside double-layer scaffold that free tongue is arranged.Support also can be the branch support.
Related flexible connection ring 7 is ingredients of support 1 among the present invention, is formed by the deformable line braiding of softness, as polyester thread (DACRON), polyethylene fibre (POLYETHYLENE), nylon wire (PA), polypropylene line (POLYPROPYLENE) etc.Its structure can have two kinds of forms, a kind of structure comprises stiff end 71 and free-end 72, its stiff end 71 rings prick the open line that is fixed on support 1 turn 102 or the netting twine cross point 104 of closed line eye 103 or support on, its free-end 72 in support or outer the extension constitute single free ring or two free ring.On the same support cross section one or more flexibly jointed chain rings can be arranged, can arrange (referring to Fig. 5) in the form of a ring between a plurality of flexibly jointed chain rings, and it be continuous to connect with one another closely.Another kind of structure is single closed wire loop as shown in Figure 2, its open line that is set on support 1 turn 102 or the netting twine cross point 104 of closed line eye 103 or support on slidably but can not break away from.
Related defeated place system includes in one pipe 2 and at least one lock silk 3 or also is provided with temporary guy 4 and middle pipe 5 among the present invention.Interior pipe 2 is an elongated pipe, can be crooked.Color preferably clear or translucent.In pipe a circle 0.035 is arranged in 2 " guidewire lumen 21 and one or more lock silk backguy chamber 22 lead to near-end from far-end.The seal wire (not shown) that can slide different in the guidewire lumen 21.Different take-up 8, temporary guy 4 and lock silk 3 can slide in the lock silk backguy chamber 22.Interior pipe 2 sections far away have one or more side opening 23 to lead to wherein one or more locks backguy chambeies 22.These side openings can be at same or different cross section, and opening is towards same or different directions.Interior pipe section far away goes up alternative and has lateral guide fiber tube 6.Lateral guide fiber tube or seal wire can come out to a plurality of direction openings on same cross section.The pore size of lateral guide fiber tube 6 can allow 0.014 at least " the diameter seal wire passes through.There is at least one lock silk 3 to slide in the lock silk backguy chamber 22 along interior pipe.Lock silk 3 is the filaments that are made of memorial alloy (Nitinol), cochrome (Phynox) elastomeric material.Lock silk 3 near-ends can come out from the near-end controller (not shown) of defeated place system.Pipe 5 during interior pipe 2 outer alternatives have, middle pipe 5 are positioned at pipe side opening 23 nearsides, and middle pipe 5 internal diameters allow it along interior pipe 2 slips greater than the external diameter of interior pipe 2.Middle pipe 5 far-ends have a distal openings 51.
Wire intaking compacting mechanism for self-expanding stent of the present invention comprises interior pipe 2 and the lock silk 3 that is used to form defeated place system, the closed line eye 103 of on the support at least one and/or at least one flexible connection ring 7, and the take-up 8 that is used to compress support, the far-end of take-up is provided with a take-up ring 81, in this take-up ring 81 is set in the pipe 2 or the lock silk 3 between interior pipe 2 and the middle pipe 5 is provisional passes pinning, same or the different side openings 23 of pipe in take-up at least twice is passed, at lock silk 3, form hold-down mechanism around knot between closed line eye 103 on the support or flexible connection ring 7 and the support outside, the near-end of take-up is drawn and is temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system.
First embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention as shown in Figure 1, this wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, be provided with closed line eye 103 (also can be closed type flexible connecting ring 7) on the cross section compressing of support 1, take-up 8 is after its far-end take-up ring 81 is blocked by lock silk 3, a side opening 23 of pipe in from inside to outside passing, pass the closed line eye 103 (or closed type flexible connecting ring 7) on the support again, outward around the about Zhou Houzai of support pass from outside to inside same closed line eye 103 (or closed type flexible connecting ring 7) and same in the pipe side opening 23 enter interior pipe, lock silk 3 in walking around in the pipe forms take-up semi-ring 82, again from inside to outside passing same interior pipe side opening and same closed line eye (or closed type flexible connecting ring 7) then draws, on a cross section of support, can lock the hold-down mechanism that to separate, draw and be temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system through the interlayer between interior pipe 2 and the middle pipe 5 at last around forming.
Second embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention as shown in Figure 2, this wire intaking compacting mechanism also is the single cross section of a single take-up hold-down mechanism, be provided with closed type flexible connecting ring 7 (or closed line eye 103) on the cross section compressing of support 1, take-up 8 is after its far-end take-up ring 81 is blocked by the lock silk, a side opening 23 of pipe in from inside to outside passing, pass closed type flexible connecting ring 7 (or closed line eye 103) again, around support 1 an about Zhou Houzai pass from outside to inside same closed type flexible connecting ring (or closed line eye 103) and same in the pipe side opening manage 2 in entering, lock silk 3 in walking around in the pipe forms take-up semi-ring 82, again from inside to outside pass same interior pipe side opening 23 and same closed type flexible connecting ring 7 (or closed line eye 103) then, again oppositely around the about Zhou Houzai of support pass from outside to inside same closed type flexible connecting ring 7 (or closed line eye 103) and same in pipe side opening 23 manage 2 in entering, on a cross section of support, can lock the hold-down mechanism that to separate, draw and be temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system through interior pipe 2 at last around forming.
The 3rd embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention as shown in Figure 3, this wire intaking compacting mechanism also is the single cross section of a single take-up hold-down mechanism, linking compressing on the cross section of support 1 has a flexible connection ring compressing structure, this flexible connection ring compressing structure is made up of the flexible connection ring 7 of the two free rings of band, the fixedly end ring of this flexible connection ring 7 is pricked and is fixed on the netting twine cross point of support, two free ring 721,722 respectively along the circumferential both sides of the rack outer surface support 1 of extended loop under radial compression near a week, and (also can keep off near place's formation relative status, apart from each other, for example at a distance of half circumference or littler, but two free rings become relative status on the same circumference of support), take-up 8 is after its far-end take-up ring 81 is blocked by lock silk 3, a side opening 23 of pipe in from inside to outside passing, pass first free ring 721 again, turn to second free ring 722 and pass this free ring from outside to inside and same in manage side opening 23 and enter interior pipe, lock silk 3 in walking around in the pipe forms take-up semi-ring 82, from inside to outside pass same interior pipe side opening 23 and second free ring 722 then, turn again to first free ring 721 and pass this free ring from outside to inside and same in manage side opening 23 and manage 2 in entering, on a cross section of support, can lock the hold-down mechanism that to separate, draw and be temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system through interior pipe 2 at last around forming.
The 4th embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention as shown in Figure 4, this wire intaking compacting mechanism also is the single cross section of a single take-up hold-down mechanism, compressing to link on the cross section of support 1 has a flexible connection ring compressing structure, this flexible connection ring compressing structure comprises a plurality of flexible connection rings 7, wherein stiff end 71 rings of two flexible connection rings are pricked and are fixed on the same netting twine cross point of support, the stiff end of all the other flexible connection rings encircles respectively to prick to be fixed on aforementioned netting twine cross point and is on the netting twine cross point on the same circumference, the free ring 72 of each flexible connection ring respectively along the support of the circumferential both sides of rack outer surface extended loop under radial compression near a week, the free ring that extends to same direction connects with one another closely continuous in order, latter two free ring 721 that extends to both direction respectively, 722 (also can keep off to latter two free ring that same direction is extended forming relative status near the place, apart from each other, for example at a distance of half circumference or littler, but two free rings become relative status on the same circumference of support).Take-up 8 is after its far-end take-up ring 81 is blocked by lock silk 3, a side opening 23 of pipe in from inside to outside passing, pass first free ring 721 again, turn to second free ring 722 and pass this free ring from outside to inside and same in manage side opening 23 and enter interior pipe, lock silk 3 in walking around in the pipe forms take-up semi-ring 82, come out from same interior pipe side opening 23 again then, on a cross section of support 1, can lock the hold-down mechanism that to separate, draw and be temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system through the interlayer between interior pipe 2 and the middle pipe 5 at last around forming.
The 5th embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention as shown in Figure 5, this wire intaking compacting mechanism is the unidirectional multi-section hold-down mechanism of single take-up, a plurality of compressing at support 1 is respectively equipped with flexible connection ring compressing structure (each flexible connection ring compressing structure is with the 3rd embodiment of Fig. 3) on the cross section, flexible connection ring compressing structure on the same cross section around the support under the radial compression near a week, and forming two relative free rings 721 near the place, 722 (two relative free rings also can be kept off, apart from each other, for example at a distance of half circumference or littler), same single take-up 8 is after its far-end take-up ring 81 is blocked by the lock silk, successively two relative free rings that pass the flexible connection ring compressing structure at the different cross section of support carry out locking can separate around knot, form successive multi-section hold-down mechanism.It is specifically as follows around the knot process:
Take-up 8 is after its far-end take-up ring 81 is blocked by lock silk 3, a side opening 23 of pipe in passing, first that passes support 1 again compresses first the free ring 721 on the cross section, turn to second of same cross section free ring 722 and pass this free ring and enter second of support 1 and compress the cross section, turn back first again at second second free ring 722 place that compresses on the cross section and compress the cross section, form take-up semi-ring 82 in the corner, take-up 8 is passed first once more and is compressed on the cross section second free ring 722, turn to first free ring 721 in same cross section and pass this free ring and enter second of support 1 again and compress the cross section, pass second first free ring 721 that compresses on the cross section and turn again to same and compress second free ring 722 on the cross section and pass this free ring 722 and backguy semi-ring 82 enters the 3rd of support 1 and compresses the cross section ...Pipe another side opening 23 of 2 passes same or another lock silk 3 forms last take-up semi-ring 82 and passed pinning by lock silk 3 is provisional in entering at last.In the knot process, take-up forms a two-wire parallel-segment respectively between same two relative free rings that compress the cross section, and forms a two-wire vertical section respectively two sides that compress between the cross section, and opposite side forms a single line vertical section respectively.Can draw and be temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system through the lock silk take-up chamber 22 or the interlayer between interior pipe 2 and the middle pipe 5 of interior pipe 2 near section of take-up.
The 6th embodiment of wire intaking compacting mechanism for self-expanding stent of the present invention as shown in Figure 6, this wire intaking compacting mechanism also is the unidirectional multi-section hold-down mechanism of a kind of single take-up, a plurality of compressing at support 1 is respectively equipped with a closed line eye 103 or also is provided with flexible connection ring 7 on the cross section, closed line eye on each cross section is arranged on same vertical long line of support or on the different anglecs of rotation, same single take-up 8 is after its far-end take-up ring 81 is blocked by the lock silk, successively the different cross section at support passes closed line eye 103 and flexible connection ring 7, forms successive multi-section hold-down mechanism.It is specifically as follows around the knot process:
Take-up 8 is after its far-end take-up ring 81 is blocked by lock silk 3, a side opening 23 of pipe in passing, first that passes support 1 again compresses the closed line eye 103 on the cross section, again laterally around the rack surface under the radial compression near a week and pass the flexible connection ring 7 that is arranged on this cross section, pass same closed line eye 103 again, second that enters support 1 compresses the cross section, turning back first after second closed line eye 103 place that compress on the cross section lays out a take-up semi-ring 82 again compresses the closed line eye 103 on the cross section and passes this closed line eye 103, the horizontal again rack surface under radial compression is near a week and pass same closed line eye 103, second that enters support 1 compresses the cross section, compress the cross section second of support 1 and pass closed line eye 103, the horizontal again rack surface under radial compression is near a week and pass same closed line eye 103 and take-up semi-ring 82, the 3rd that enters support 1 compresses the cross section ...Pipe another side opening 23 of 2 passes same or another lock silk 3 forms last take-up semi-ring 82 and passed pinning by lock silk 3 is provisional in entering at last.Can draw and be temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system through the lock silk take-up chamber 22 or the interlayer between interior pipe 2 and the middle pipe 5 of interior pipe 2 near section of take-up.
Flexible connection ring compressing mechanism of the present invention can also be the combination of the two-way multi-section hold-down mechanism of single take-up, the unidirectional multi-section hold-down mechanism of two take-up, the two-way multi-section hold-down mechanism of two take-up or above-mentioned various single cross section hold-down mechanism and multi-section hold-down mechanism, its concrete structure and the various embodiments described above are similar, and embodiment no longer is provided.
Flexible connection ring compressing mechanism of the present invention can also comprise temporary guy 4 and the pipe 5 that is used for forming defeated place system, and the 7th embodiment of flexible connection ring compressing mechanism of the present invention promptly is this structure, as shown in Figure 7.Take-up 8 in its far-end take-up ring 81 is set at, manage 2 and middle pipe 5 between lock silk 3 block after, from inside to outside pass a closed line eye 103 on the support, laterally the rack surface under radial compression also passes same closed line eye 103 from outside to inside near a week again, and the interlayer in entering between pipe 2 and the middle pipe 5 is drawn and is temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system.The far-end of temporary guy is arranged between the interior Guan Yuzhong pipe and walks around take-up 8 formation two-wires near far-end take-up ring take-up is held to near-end.
The function and the operation principle of wire intaking compacting mechanism for self-expanding stent of the present invention are:
A), take-up is softish fine rule, any line turns with the take-up semi-ring and can be out of shape, become straight, the position between each section of support take-up can change.
B), take-up is represented the degree of tightness of take-up or the radial compression level of support in the length of the two-wire vertical section that forms in the knot process, the near-end of pulling take-up, the both sides of the same closed line eye that is passed by take-up or both sides or two relative free rings of same closed free ring can provisionally be tightened up, and the support in it is by radial compression.
C), in the interior pipe except thick wire leading pipe is arranged, the interior pipe on interior or the interior pipe also can have the lateral guide fiber tube, can guide thin seal wire guiding and the vertical direction of interior pipe, the position level of lateral guide fiber tube distal openings and direction of rotation and interior pipe side opening have fixed relation, thereby indirect and adjustable relation are arranged with stent valve or the self-extending type overlay film frame of windowing, the not deformable unit of overlay film is arranged on the stent valve, and the overlay film frame of windowing has window can allow the side direction seal wire pass.
D) if to near-end zip silk, lock silk slides to near-end, and lock silk far-end skids off far-end take-up ring or last take-up semi-ring of take-up, take-up release lock silk and obtain to discharge.
E), after take-up release lock silk to discharge, pulling take-up near-end, take-up is by removing all connections around the opposite order of knot, defeated place system near-end can be all received in take-up.
F), different with the deformable unit on the support, the size and the shape of the closed line eye on the support do not change with the variation of the straight warp of support, do not change down even pull in the take-up of passing yet.
G), temporary guy can entangle take-up or far-end take-up ring under the cooperation of lock silk, to near-end pulling backguy the defeated place system near-end of far-end take-up hoop of take-up is slided.
Claims (14)
1. a wire intaking compacting mechanism for self-expanding stent is used for compressing this support when self-expanding stent is implanted cardiovascular; Described self-expanding stent be can radial deformation pipe type netted structure, surround a plurality of deformables unit between each netting twine of support, the two ends of support form a plurality of open lines and turn, and support is provided with at least one closed line eye and/or is connected with at least one flexible connection ring; Described self-expanding stent can carry out implanting cardiovascular release after the radial compression with multiple open defeated place system, described defeated place system includes pipe and at least one lock silk in one, far away section of interior pipe interts in support and is provided with at least one side opening or also is provided with a lateral guide fiber tube, the lock silk is arranged in the interior pipe, it is characterized in that: described wire intaking compacting mechanism comprises the take-up that is used to form interior pipe and at least one closed line eye and/or at least one flexible connection ring on lock silk and the support of defeated place system and/or is used to compress support, the far-end of take-up is provided with a take-up ring, take-up is after its far-end take-up ring is lived by locking wire lock, the side opening of pipe in passing, can lock the hold-down mechanism that can separate around knot formation between the closed line eye on lock silk and the support and/or the flexible connection ring and the support outside, the near-end of take-up is drawn and is temporarily fixed on the near-end controller of defeated place system from the near-end of defeated place system.
2. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described defeated place system also is provided with temporary guy and middle pipe, pipe box is managed slip in described in interior pipe outer, and described temporary guy is arranged in the interior pipe or in the interlayer between the interior Guan Yuzhong pipe.
3. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, on a cross section of support, be provided with a closed line eye or a closed type flexible connecting ring, described take-up is after its far-end take-up ring is lived by locking wire lock, a side opening of pipe in from inside to outside passing, pass closed line eye or closed type flexible connecting ring on the support again, outward around the about Zhou Houzai of support pass from outside to inside same closed line eye or closed type flexible connecting ring and same in the pipe side opening enter interior pipe, lock silk in walking around in the pipe forms the take-up semi-ring, again from inside to outside pass same interior pipe side opening and same closed line eye or closed type flexible connecting ring then and draw, on a cross section of support, can lock the hold-down mechanism that to separate around forming.
4. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, on a cross section of support, be provided with a closed line eye or a closed type flexible connecting ring, described take-up is after its far-end take-up ring is lived by locking wire lock, a side opening of pipe in from inside to outside passing, pass closed line eye or closed type flexible connecting ring again, around the about Zhou Houzai of support pass from outside to inside same closed line eye or closed type flexible connecting ring and same in the pipe side opening enter interior pipe, lock silk in walking around in the pipe forms the take-up semi-ring, again from inside to outside pass same interior pipe side opening and same closed line eye or closed type flexible connecting ring then, oppositely around the about Zhou Houzai of support pass from outside to inside same closed line eye or closed type flexible connecting ring and same in the pipe side opening enter in the Guan Bingcong pipe draw, on a cross section of support, can lock the hold-down mechanism that can separate around forming.
5. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, on a cross section of support, link a flexible connection ring compressing structure is arranged, this flexible connection ring compressing structure is around a discontented week of the support under the radial compression, and form two relative free rings, described take-up its far-end take-up ring locked the silk block after, a side opening of pipe in from inside to outside passing, pass first free ring again, turn to second free ring and pass this free ring from outside to inside and same in manage side opening and enter interior pipe, lock silk in walking around in the pipe forms the take-up semi-ring, and then from inside to outside pass same in the free ring of pipe side opening and second, turn again to first free ring and pass this free ring from outside to inside and same in manage side opening enter in the Guan Bingcong pipe draw, on a cross section of support, can lock the hold-down mechanism that can separate around forming.
6. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism is the single cross section of a single take-up hold-down mechanism, on a cross section of support, link a flexible connection ring compressing structure is arranged, this flexible connection ring compressing structure is around a discontented week of the support under the radial compression, and form two relative free rings, described take-up its far-end take-up ring locked the silk block after, a side opening of pipe in from inside to outside passing, pass first free ring again, turn to second free ring and pass this free ring from outside to inside and same in manage side opening and enter interior pipe, lock silk in walking around in the pipe forms the take-up semi-ring, from inside to outside pass then same in pipe side opening and draw from the interior pipe outside, on a cross section of support, can lock the hold-down mechanism that can separate around forming.
7. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism is the unidirectional multi-section hold-down mechanism of single take-up, on a plurality of cross sections of support, be respectively equipped with closed line eye or flexible connection ring compressing structure, flexible connection ring compressing structure on the same cross section is around a discontented week of the support under the radial compression, and form two relative free rings, same single take-up is after its far-end take-up ring is locked silk and blocked, successively two relative free rings that pass closed line eye or flexible connection ring compressing structure at the different cross section of support carry out locking can separate around knot, form successive multi-section hold-down mechanism.
8. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism is the two-way multi-section hold-down mechanism of single take-up, on a plurality of cross sections of support, be respectively equipped with closed line eye or flexible connection ring compressing structure, flexible connection ring compressing structure on the same cross section is around a discontented week of the support under the radial compression, and form two relative free rings, same single take-up is after its far-end take-up ring is locked silk and blocked, earlier to a direction the different cross section of support carry out locking can separate around knot, return along former road then carry out for the second time carrying out locking can separate around knot, form successive multi-section hold-down mechanism, both direction around between the knot section, take-up can be by provisional the blocking once of lock silk.
9. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism is two unidirectional multi-section hold-down mechanisms of take-up, on a plurality of cross sections of support, be respectively equipped with closed line eye or flexible connection ring compressing structure, flexible connection ring compressing structure on the same cross section is around a discontented week of the support under the radial compression, and form two relative free rings, two take-ups are after its far-end take-up ring is blocked by the lock silk respectively, respectively from the mutually antisymmetric direction of support the different cross section of support carry out locking can separate around knot, form successive multi-section hold-down mechanism.
10. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism is two two-way multi-section hold-down mechanisms of take-up, on a plurality of cross sections of support, be respectively equipped with closed line eye or flexible connection ring compressing structure, flexible connection ring compressing structure on the same cross section is around a discontented week of the support under the radial compression, and form two relative free rings, two take-ups are after its far-end take-up ring is blocked by the lock silk respectively, respectively from the mutually antisymmetric direction of support earlier to a direction the different cross section of support carry out locking can separate around knot, return along former road then carry out can locking for the second time can separate around knot, form successive multi-section hold-down mechanism, same take-up can be by provisional the blocking once of lock silk between the knot section both direction.
11. as any one described wire intaking compacting mechanism for self-expanding stent in the claim 5 to 10, it is characterized in that: described flexible connection ring compressing structure is the flexible connection ring of the two free rings of band, the fixedly end ring of this flexible connection ring is pricked and is fixed on the netting twine cross point of support, two free ring is respectively along a discontented week of the support of the circumferential both sides of rack outer surface extended loop under radial compression, and the formation relative status.
12. as any one described wire intaking compacting mechanism for self-expanding stent in the claim 5 to 10, it is characterized in that: described flexible connection ring compressing structure comprises a plurality of flexible connection rings, wherein the fixedly end ring of two flexible connection rings is pricked and is fixed on the same netting twine cross point of support, the stiff end of all the other flexible connection rings encircles respectively to prick to be fixed on aforementioned netting twine cross point and is on the different netting twines cross point on the same circumference, the free ring of each flexible connection ring is respectively along a discontented week of the support of the circumferential both sides of rack outer surface extended loop under radial compression, the free ring that extends to same direction connects with one another closely continuous in order, and latter two the free ring that extends to both direction forms relative status respectively.
13. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1, it is characterized in that: described wire intaking compacting mechanism also comprises temporary guy and the pipe that is used for forming defeated place system, described take-up its far-end take-up ring by the lock silk between the interior Guan Yuzhong pipe is provisional pass pinning after, from inside to outside pass a closed line eye on the support, laterally the rack surface under radial compression also passes same closed line eye from outside to inside near a week again, draw from the near-end of defeated place system through the interlayer between the interior Guan Yuzhong pipe, the far-end of temporary guy is arranged between the interior Guan Yuzhong pipe and walks around take-up formation two-wire near far-end take-up ring take-up is held to near-end.
14. wire intaking compacting mechanism for self-expanding stent as claimed in claim 1 is characterized in that: described wire intaking compacting mechanism is the combination in any of various single cross section hold-down mechanisms and multi-section hold-down mechanism.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100252972A CN101045023B (en) | 2006-03-30 | 2006-03-30 | Wire intaking compacting mechanism for self-expanding stent |
| US12/093,197 US20090048656A1 (en) | 2005-11-09 | 2006-11-07 | Delivery Device for Delivering a Self-Expanding Stent |
| PCT/CN2006/002973 WO2007054014A1 (en) | 2005-11-09 | 2006-11-07 | Delivery device for delivering a self-expanding stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100252972A CN101045023B (en) | 2006-03-30 | 2006-03-30 | Wire intaking compacting mechanism for self-expanding stent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101045023A CN101045023A (en) | 2007-10-03 |
| CN101045023B true CN101045023B (en) | 2011-04-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2006100252972A Active CN101045023B (en) | 2005-11-09 | 2006-03-30 | Wire intaking compacting mechanism for self-expanding stent |
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| CN (1) | CN101045023B (en) |
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| DK2582333T3 (en) * | 2010-06-18 | 2016-07-25 | Cook Medical Technologies Llc | FEED SYSTEM FOR bifurcated stent |
| DE102010061371A1 (en) * | 2010-12-20 | 2012-06-21 | Transcatheter Technologies Gmbh | Individual shaft fiber device and kit for folding or deploying a medical implant and method |
| CN102247230B (en) * | 2011-06-24 | 2013-08-14 | 淮安市西格玛医用实业有限公司 | Conveyor of self-expanding stents |
| AU2017278331B2 (en) * | 2016-06-06 | 2020-01-30 | Medtronic Vascular Inc. | Transcatheter prosthetic heart valve delivery system with lateral offset control |
| US10076428B2 (en) * | 2016-08-25 | 2018-09-18 | DePuy Synthes Products, Inc. | Expansion ring for a braided stent |
| US10842619B2 (en) * | 2017-05-12 | 2020-11-24 | Edwards Lifesciences Corporation | Prosthetic heart valve docking assembly |
| CN110786975B (en) * | 2018-08-03 | 2022-07-05 | 先健科技(深圳)有限公司 | Handle assembly of conveyor, conveyor and conveying system |
| CN109620491B (en) * | 2018-12-26 | 2020-08-11 | 乐畅医疗器械(上海)有限公司 | Radial uniform compression tool for stent and use method thereof |
| CN114617686A (en) * | 2020-12-11 | 2022-06-14 | 上海微创心通医疗科技有限公司 | Stent delivery system assembly and prosthetic valve delivery system assembly |
| CN116059006A (en) * | 2021-11-04 | 2023-05-05 | 上海微创心通医疗科技有限公司 | Wire control bracket, wire control bracket assembly and conveying device |
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Address after: 102200 Beijing City, Changping District science and Technology Park East China Chang Road No. 2 Patentee after: Beijing Bai Ren medical Polytron Technologies Inc Address before: 102200 Beijing City, Changping District science and Technology Park East China Chang Road No. 2 Patentee before: BEIJING BAIREN MEDICAL TECHNOLOGY |