CN100560037C - Artificial nerve catheter from the functional amplification of body - Google Patents
Artificial nerve catheter from the functional amplification of body Download PDFInfo
- Publication number
- CN100560037C CN100560037C CN 200710056384 CN200710056384A CN100560037C CN 100560037 C CN100560037 C CN 100560037C CN 200710056384 CN200710056384 CN 200710056384 CN 200710056384 A CN200710056384 A CN 200710056384A CN 100560037 C CN100560037 C CN 100560037C
- Authority
- CN
- China
- Prior art keywords
- inner sleeve
- artificial nerve
- centimetre
- nerve catheter
- catheter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The invention discloses the used artificial nerve catheter of a kind of medical domain surgical operation from the functional amplification of body.Aim to provide a kind of long section, thick and the requirement of many places peripheral nerve defection surgical repair that is applicable to, the neural segment of continuous, spaced placement promotes the artificial nerve catheter of nerve growth.Described artificial nerve catheter includes trocar sheath and the inner sleeve that adopts Biodegradable material to make, trocar sheath is sleeved on the inner sleeve coaxial line, inner sleeve can stretch out along the axis of trocar sheath or indentation, in inner sleeve, be placed with array inner sleeve support, every group of storage chamber that the inner sleeve support promptly is made up of two single inner sleeve supports, distance is 0.3 centimetre to 0.5 centimetre between two single inner sleeve supports of storage intracavity, and distance is 0.5 centimetre between adjacent two storage chambeies.The face shaping of trocar sheath and inner sleeve is that cross section is the thin-walled body of oval ring.Inner sleeve mileage group inner sleeve support is fixedly connected with three artificial substratum bridges.
Description
Technical field
The present invention relates to the artificial neuron product of a kind of medical domain surgical operation clinical practice, relate to a kind of artificial nerve catheter or rather from the functional amplification of body.
Background technology
Long section, reparation thick and the many places peripheral nerve defection are the still unsolved so far difficult problems of surgical field.Nerve autograft is repaired neurologic defect, be acknowledged as ideal method, but owing to can only repair the major function nerve with the tegumentary nerve of very thin secondary function, not only repairing effect is not good enough, and owing to the nerve disappearance for the district causes new dysfunction occurring for the district, so the autologous nerve source is greatly limited.
Allosome and xenogenesis neural transplantation because xenogenesis neural transplantation rejection is still unresolved, only limit to the animal experiment study stage.
Therefore, people begin the human nerve that the using artificial neural conduit comes repair deficiency.According to the difference of material therefor, artificial nerve catheter can be divided into three major types:
1. the biotype material mainly comprises vein, tremulous pulse, skeletal muscle, cord vessels etc.;
2. abiotic degradable synthetic material mainly contains silica gel tube;
3. the biodegradable synthetic material mainly comprises chitin, chitosan, polylactic acid etc.
Whether in addition, can be absorbed by human body according to artificial nerve catheter, the used material of artificial nerve catheter can be divided into absorbable material and absorbable material not; According to the situation of artificial nerve catheter to surrounding material permeability, the used material of artificial nerve catheter can be divided into half permeable materials and non-permeable materials etc.
Single artificial nerve catheter has certain effect in the reparation of short distance (less than 3 centimetres) neurologic defect, but lack active single non-nervous tissue can't repair in, a long section neurologic defect.
Promote nerve growth though there is the people in artificial nerve catheter, to place a neural segment abroad in the document, be only limited to short distance (less than 3 centimetres) neurologic defect situation.Continuously, the neural segment of spaced placement promote in, long section (greater than 10 a centimetres) nerve growth, yet there are no the pertinent literature report.
Summary of the invention
Technical problem to be solved by this invention provides a kind of artificial nerve catheter, a kind of long section, thick and the requirement of many places peripheral nerve defection surgical repair that is specially adapted to especially is provided, and the neural segment of continuous, spaced placement promotes the artificial nerve catheter from the functional amplification of body of nerve growth.
Consult Fig. 1, for addressing the above problem, the present invention adopts following technical scheme to be achieved.Described artificial nerve catheter from the functional amplification of body is made up of trocar sheath and inner sleeve, array inner sleeve support and three artificial substratum bridges of adopting Biodegradable material to make; Trocar sheath is sleeved on the inner sleeve coaxial line, inner sleeve can stretch out in trocar sheath or indentation along coaxial line, in inner sleeve, be placed with array inner sleeve support along axis, every group of inner sleeve support is made up of two independent inner sleeve supports, formed space is called the storage chamber between two independent inner sleeve supports, the distance L between two single inner sleeve supports of storage intracavity
1Be 0.3 centimetre to 0.5 centimetre, the distance L between the adjacent two storage chambeies
2It is 0.5 centimetre.Array inner sleeve support is fixedly connected with three artificial substratum bridges that are parallel to the inner sleeve axis.
The width of the single inner sleeve support described in the technical scheme is 0.3 centimetre to 0.5 centimetre, the profile of single inner sleeve support is oval, the ellipsoid of inner sleeve support is processed into netted, and angle is 90 ° to 140 ° between horizontal netting twine parallel to each other and the vertical netting twine parallel to each other; The described array inner sleeve support that in inner sleeve, is placed with, be meant and determine in inner sleeve, to be placed with that to be one group at least be at most ten groups inner sleeve support according to the human nerve damage length, determine promptly in inner sleeve, to be built with that to be one at least be at most ten storage chamber; The face shaping of the trocar sheath of described artificial nerve catheter from the functional amplification of body is that cross section is the thin-walled body of oval ring, and inner sleeve is that cross section is that the thin-walled body and the centre of oval ring is that cross section is that the face shaping that the annular half thin-walled body of semiellipse is formed is the thin-walled body of U font by two ends; Described three artificial substratum bridges are to be two of centrosymmetry fixed and arranged along the long axis direction of inner sleeve support ellipsoid with the intersection point of major axis and minor axis on array inner sleeve support, and fixed and arranged is one on the intersection point of major axis and minor axis; Described Biodegradable material is meant chitin, chitosan, polycaprolactone (PCL) and polylactic acid (PLA) copolymer; Described artificial nerve catheter use length from the functional amplification of body can be standby according to the artificial nerve catheter from the functional amplification of body that the thickness of the damaged nerve of clinical human body, damaged neural length be processed into different model.
The invention has the beneficial effects as follows:
1. the autologous nerve of using small size amplifies autologous nerve by the pipe support structure of new bio degradation material from function, for solve limited this difficult problem in autologous nerve source provide newly by way of.
2. the application of new bio degradation material pipe support structure has overcome abiotic degradable pipe and long term the chronic embedding of nerve has been pressed.
3. simple to operate, only need cut far-end in the operation between the default inner sleeve support in the artificial nerve catheter of the functional amplification of body that the new bio degradation material that the neural fragment and the fixed point of the very thin secondary function of body is positioned over it different size is made.
4. the degradable biological synthetic material of the present invention's application all is to be applied to clinical biosynthesis material, and human body is not had any untoward reaction, does not therefore need to do any toxicity and immunological experiment, but can directly apply to clinical.
5. the artificial nerve catheter from the functional amplification of body made of new bio degradation material is cheap; The autologous nerve of the secondary function that the far-end of small size is very thin draws materials conveniently, safe and practical, do not need repeatedly, the many places operation, patient is easy to accept.
Description of drawings
The present invention is further illustrated below in conjunction with accompanying drawing:
Fig. 1 is the assembly structure sketch map along trocar sheath axis pinch in from the inner sleeve of the artificial nerve catheter of the functional amplification of body;
Fig. 2 is the assembly structure sketch map of stretching along the trocar sheath axis from the inner sleeve of the artificial nerve catheter of the functional amplification of body;
Fig. 3 is the structural representation from the inner sleeve of the artificial nerve catheter of the functional amplification of body;
Among the figure: 1. trocar sheath, 2. inner sleeve, 3. inner sleeve support, 4. artificial substratum bridge.
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing:
Consult Fig. 1 to Fig. 3, adopting the cross section that new bio degradation material polycaprolactone (PCL) or polylactic acid (PLA) copolymer are processed into artificial nerve catheter is trocar sheath 1, several single inner sleeve supports 3, the artificial substratum bridge 4 and inner sleeve 2 of the thin-walled body of oval ring.Inner sleeve 2 is that cross section is that the thin-walled body of oval ring and centre are to be that the face shaping that the annular half thin-walled body of semiellipse is formed is the thin-walled body of U font along oval ring long axis direction cross section by two ends, the width of single inner sleeve support 3 is 0.3 centimetre to 0.5 centimetre, the profile of single inner sleeve support 3 is oval, the ellipsoid of inner sleeve support 3 is processed into netted, and angle is 90 ° to 140 ° between horizontal netting twine parallel to each other and the vertical netting twine parallel to each other.Inner sleeve 2 can be determined with the storage chamber that makes up sufficient amount according to the thickness of the length of damaged nerve, damaged nerve with the length of trocar sheath 1 cross section oval ring major axis and minor axis with length, the inner sleeve 2 of trocar sheath 1.Inner sleeve 2 is packed within the trocar sheath 1, and inner sleeve 2 will reach two tubular axis line conllinear with the accuracy of manufacture of trocar sheath 1, and inner sleeve 2 can vertically be free to slide along axis within trocar sheath 1, and inner sleeve 2 can conveniently within the trocar sheath 1 take out and conveniently put into.Take out inner sleeve 2 for 1 li from trocar sheath, length according to the damaged nerve that will repair is placed corresponding array inner sleeve support for 2 li at inner sleeve, promptly make up the storage chamber of sufficient amount, the length in storage chamber is 0.3 centimetre to 0.5 centimetre, the distance in two storage chambeies is 0.5 centimetre, three artificial substratum bridges 4 of reuse are fixedly connected array inner sleeve support, and it is become one.Three artificial substratum bridges 4 are parallel to the axis of inner sleeve 2, three artificial substratum bridges 4 are that centrosymmetry is arranged two at the long axis direction of array inner sleeve support upper edge inner sleeve support ellipsoid with the intersection point of major axis and minor axis, and layout is one on the intersection point of major axis and minor axis; Between two inner sleeve supports 3 in storage chamber, place the autologous nerve segment that cuts, will place the pulsating inner sleeve 2 of autologous nerve then and put into trocar sheath 1, will make the human body that good whole artificial nerve catheter is positioned over needs repairing again.Use operation method at last artificial nerve trachea is connected in the neurologic defect position.The segmental work of autologous nerve of fixed point, interruption implantation small size is implemented to finish like this.
Manufacturing from the Biodegradable material that artificial nerve catheter adopted of the functional amplification of body except polycaprolactone (PCL) or polylactic acid (PLA) copolymer, also adoptable Biodegradable material also has chitin and chitosan, can satisfy clinical requirement equally.
The required clinically artificial nerve catheter from the functional amplification of body may be various, so, in order to satisfy clinical needs, can be standby according to the artificial nerve catheter that the neural thickness of the human body breakage of clinical practice, damaged neural length are processed into different model from the functional amplification of body.
Artificial nerve trachea is connected in the operational approach at neurologic defect position:
At first anesthesia back is cut skin, is appeared from disconnected, damaged peripheral nerve, with scalpel, after distal nerve is trimmed to normal nervous tissue, measure the physical length of neurologic defect, selects the artificial nerve trachea of respective length for use nearly.Earlier artificial nerve trachea inner sleeve 2 is vertically pulled out, group number according to the default support of inner sleeve, cut the branchiess normal nervous tissue segment of far-end of a plurality of suitable lengths (0.3 centimetre-0.5 centimetre), and place it in default storage intracavity, with artificial nerve trachea inner sleeve withdrawal, artificial nerve trachea trocar sheath 1 and near, distal nerve broken ends of fractured bone adventitia are carried out interrupted suture with 5/0 no wound stitching thread.
The structure of artificial nerve trachea and experimental analysis:
Along with the development of polymer material science, adopt special process catalysis to synthesize new bio degradation material polycaprolactone (PCL) and polylactic acid (PLA) copolymer.Can control molecular weight of product, paradigmatic structure and degradation time by the ratio of artificial adjustment response time, monomer and catalyst.Put into practice verified, this copolymer good biocompatibility, do not find toxicity and immunological rejection and mutagenesis the reaction, the termination product be carbon dioxide and water, human body is not had any untoward reaction.Thisly possess " bite the hand which has fed one ' Biodegradable material of performance, can remove general bridge pipe from and long term the chronic embedding of nerve be pressed, can become the ideal carrier that promotes autologous nerve regeneration activity material, have special superiority to repairing neurologic defect.
By the tissue engineering means, we organically combine the carcass Schwann cell of the pipe support structure of this Biodegradable material and purification, and the tissue engineered peripheral nerve of preparation has been repaired in the rat sciatic nerve, long section is damaged more satisfactoryly.The solution of the problems such as purification, preservation and graft-rejection of human carcass Schwann cell has also obtained progress.Recently, Ikuta etc. studies confirm that: the near-end nerve of fracture is connected in the silicone tube of opening of 10mm, does not find neuranagenesis after six weeks; And the distal nerve fragment of different volumes (the long whole cross section of 5mm, the long whole cross section of 1mm, the long half section of 1mm) is implanted the open silicone tube far-end of 10mm, regenerating nerve is successfully crossed over the quality no significant difference of regenerating between silicone tube and the neural slice groups of different volumes.This result repairs neurologic defect for the development and use autologous nerve new way is provided.On the basis of these work, the pipe support structure fixed point that the finishing of success of the present invention used the new bio degradation material, be interrupted the autologous nerve fragment of implanting small size, to repair long section, thick peripheral nerve defection.
Select in the human limb, the case of long section peripheral nerve defection, the neuranagenesis that can farthest promote that the animal experiment study in applying clinical early stage is determined is repaired the autologous nerve of the amplification of neurologic defect, repair patient in, long section peripheral nerve defection.Respectively by two point discrimination, electromyogram and ninhydrin test,, all obtained satisfactory result to recovering to compare Journal of Sex Research with sensation, motion and the sympathetic nerve function of postoperative before the art.
Claims (7)
1. artificial nerve catheter from the functional amplification of body, it is characterized in that described artificial nerve catheter from the functional amplification of body is made up of the trocar sheath (1) that adopts Biodegradable material to make and inner sleeve (2), array inner sleeve support and three artificial substratum bridges (4); Trocar sheath (1) being sleeved on inner sleeve (2) coaxial line, inner sleeve (2) can stretch out or indentation in trocar sheath (1) along coaxial line, be placed with array inner sleeve support in inner sleeve (2) lining along axis, every group of inner sleeve support is made up of two independent inner sleeve supports (3), formed space is called the storage chamber between two independent inner sleeve supports (3), the distance L between two independent inner sleeve supports (3) in formation storage chamber
1Be 0.3 centimetre to 0.5 centimetre, the distance L between the adjacent two storage chambeies
2Be 0.5 centimetre, array inner sleeve support is fixedly connected with three artificial substratum bridges (4) that are parallel to inner sleeve (2) axis.
2. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that, the width of single inner sleeve support (3) is 0.3 centimetre to 0.5 centimetre, the profile of single inner sleeve support (3) is oval, the ellipsoid of inner sleeve support (3) is processed into that angle is 90 ° to 140 ° between netted, parallel to each other horizontal netting twine and the vertical netting twine parallel to each other.
3. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that, describedly be placed with array inner sleeve support in inner sleeve (2) lining, be meant and determine to be placed with that to be one group at least be at most ten groups inner sleeve support according to the human nerve damage length, determine promptly to be built with that to be one at least be at most ten storage chamber in inner sleeve (2) lining in inner sleeve (2) lining.
4. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that, the face shaping of the trocar sheath (1) of described artificial nerve catheter from the functional amplification of body is that cross section is the thin-walled body of oval ring, and inner sleeve (2) is that cross section is that the thin-walled body and the centre of oval ring is that cross section is that the face shaping that the annular half thin-walled body of semiellipse is formed is the thin-walled body of U font by two ends.
5. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that, described three artificial substratum bridges (4) are to be two of centrosymmetry fixed and arranged along the long axis direction of inner sleeve support (3) ellipsoid with the intersection point of major axis and minor axis on array inner sleeve support, and fixed and arranged is one on the intersection point of major axis and minor axis.
6. according to the described artificial nerve catheter of claim 1, it is characterized in that described Biodegradable material is meant chitin, chitosan, polycaprolactone or copolymer of poly lactic acid from the functional amplification of body.
7. according to the described artificial nerve catheter of claim 1 from the functional amplification of body, it is characterized in that described artificial nerve catheter use length from the functional amplification of body can be standby according to the artificial nerve catheter from the functional amplification of body that the thickness of the damaged nerve of clinical human body, damaged neural length be processed into different model.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710056384 CN100560037C (en) | 2007-12-06 | 2007-12-06 | Artificial nerve catheter from the functional amplification of body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710056384 CN100560037C (en) | 2007-12-06 | 2007-12-06 | Artificial nerve catheter from the functional amplification of body |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101204336A CN101204336A (en) | 2008-06-25 |
| CN100560037C true CN100560037C (en) | 2009-11-18 |
Family
ID=39564972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200710056384 Expired - Fee Related CN100560037C (en) | 2007-12-06 | 2007-12-06 | Artificial nerve catheter from the functional amplification of body |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100560037C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8758374B2 (en) | 2010-09-15 | 2014-06-24 | University Of Utah Research Foundation | Method for connecting nerves via a side-to-side epineurial window using artificial conduits |
| US9931121B2 (en) | 2011-10-17 | 2018-04-03 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
| US10842494B2 (en) | 2011-10-17 | 2020-11-24 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474423B (en) * | 2008-10-24 | 2013-02-27 | 清华大学 | Nerve conduit stent and preparation method thereof |
| CN101579247B (en) * | 2009-06-23 | 2012-02-29 | 许和平 | I-type collagen peripheral nerve sheath keeping the peculiar triple helical structure of collagen, preparation method and applications thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4662884A (en) * | 1984-04-25 | 1987-05-05 | University Of Utah Research Foundation | Prostheses and methods for promoting nerve regeneration |
| US4669474A (en) * | 1984-01-12 | 1987-06-02 | Minnesota Mining And Manufacturing Company | Absorbable nerve repair device and method |
| US4778467A (en) * | 1984-04-25 | 1988-10-18 | The University Of Utah | Prostheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas |
| US5026381A (en) * | 1989-04-20 | 1991-06-25 | Colla-Tec, Incorporated | Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit |
| CN1360484A (en) * | 1999-07-07 | 2002-07-24 | 达比古股份有限公司 | Artificial neural tube |
| CN1449850A (en) * | 2002-04-11 | 2003-10-22 | 财团法人工业技术研究院 | Multi-channel type biological absorptive nerve regeneration conduit and mfg method thereof |
| US20040199187A1 (en) * | 2003-04-02 | 2004-10-07 | Frank Loughran | Nerve protecting tube |
| CN1589913A (en) * | 2003-09-02 | 2005-03-09 | 中国人民解放军第四军医大学口腔医学院 | Tissue engineering peripheral nerve used for repairing peripheral nerve defect and its preparation method |
| CN1986006A (en) * | 2005-12-20 | 2007-06-27 | 广州知光生物科技有限公司 | Biological nerve duct |
| CN201230913Y (en) * | 2007-12-06 | 2009-05-06 | 崔树森 | Human nerve conduit with amplified self-functionality |
-
2007
- 2007-12-06 CN CN 200710056384 patent/CN100560037C/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4669474A (en) * | 1984-01-12 | 1987-06-02 | Minnesota Mining And Manufacturing Company | Absorbable nerve repair device and method |
| US4662884A (en) * | 1984-04-25 | 1987-05-05 | University Of Utah Research Foundation | Prostheses and methods for promoting nerve regeneration |
| US4778467A (en) * | 1984-04-25 | 1988-10-18 | The University Of Utah | Prostheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas |
| US5026381A (en) * | 1989-04-20 | 1991-06-25 | Colla-Tec, Incorporated | Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit |
| CN1360484A (en) * | 1999-07-07 | 2002-07-24 | 达比古股份有限公司 | Artificial neural tube |
| CN1449850A (en) * | 2002-04-11 | 2003-10-22 | 财团法人工业技术研究院 | Multi-channel type biological absorptive nerve regeneration conduit and mfg method thereof |
| US20040199187A1 (en) * | 2003-04-02 | 2004-10-07 | Frank Loughran | Nerve protecting tube |
| CN1589913A (en) * | 2003-09-02 | 2005-03-09 | 中国人民解放军第四军医大学口腔医学院 | Tissue engineering peripheral nerve used for repairing peripheral nerve defect and its preparation method |
| CN1986006A (en) * | 2005-12-20 | 2007-06-27 | 广州知光生物科技有限公司 | Biological nerve duct |
| CN201230913Y (en) * | 2007-12-06 | 2009-05-06 | 崔树森 | Human nerve conduit with amplified self-functionality |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8758374B2 (en) | 2010-09-15 | 2014-06-24 | University Of Utah Research Foundation | Method for connecting nerves via a side-to-side epineurial window using artificial conduits |
| US9931121B2 (en) | 2011-10-17 | 2018-04-03 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
| US10772633B2 (en) | 2011-10-17 | 2020-09-15 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
| US10842494B2 (en) | 2011-10-17 | 2020-11-24 | University Of Utah Research Foundation | Methods and devices for connecting nerves |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101204336A (en) | 2008-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN201230913Y (en) | Human nerve conduit with amplified self-functionality | |
| CN103800097B (en) | A kind of tissue repair fibrous membrane and manufacture method thereof and application | |
| CN103747746B (en) | Drug-eluting self-retaining sutures and methods relating thereto | |
| CN100560037C (en) | Artificial nerve catheter from the functional amplification of body | |
| JP4605985B2 (en) | Nerve regeneration induction tube | |
| CN102481149B (en) | There is the coating line of the anchoring structure for carrying out grappling in biological tissue | |
| CN103800096B (en) | Pelvic floor dysfunction disease reparation is with implanting fiber diaphragm, preparation method and the medical apparatus and instruments containing it | |
| US11638640B2 (en) | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material | |
| CN103800942B (en) | Pelvic floor patch | |
| EP2921136A1 (en) | Fiber membranes for repairing tissue and products and preparation method thereof | |
| CN103068323A (en) | Suture delivery tools for endoscopic and robot-assisted surgery and methods | |
| JP2007523672A (en) | Stretchable tissue support member and method of forming the support member | |
| CN101815545A (en) | Be used to promote the prosthese of reconstruction in hollow organ or the hollow organ's part body | |
| CN203220462U (en) | Perforated biological patch | |
| CN101820930A (en) | Biomaterial scaffolds for controlled tissue growth | |
| US11883275B2 (en) | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material | |
| CA3176297A1 (en) | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material | |
| CN108379667A (en) | A kind of new bio degradation nerve trachea and its technology of preparing | |
| CN109106981A (en) | The collagen scaffold of dual modification and the application in the product for repairing spinal cord injury | |
| CN105748171A (en) | Biological type nerve conduit | |
| CN102920528A (en) | Hollowed-out membrane used as hernia patch and preparation method thereof | |
| CN202821713U (en) | Hollow membrane for colic patch | |
| CN109876197A (en) | A kind of 3D printing skin and preparation method thereof | |
| RU2440789C1 (en) | Method of replacing fenestrated tracheal and laryngeal defects | |
| CN201253230Y (en) | One-piece urethra hanging strip |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091118 Termination date: 20121206 |