CN100535635C - Portable dry method instrument for quickly detecting optical and biochemical parameters - Google Patents
Portable dry method instrument for quickly detecting optical and biochemical parameters Download PDFInfo
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- CN100535635C CN100535635C CNB2006100721439A CN200610072143A CN100535635C CN 100535635 C CN100535635 C CN 100535635C CN B2006100721439 A CNB2006100721439 A CN B2006100721439A CN 200610072143 A CN200610072143 A CN 200610072143A CN 100535635 C CN100535635 C CN 100535635C
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Abstract
The invention discloses a portable dry method optics quick detection instrument for biochemical parameter, which is based on light reflection method and has high stability and accuracy. The detection instrument mainly includes: a light source drive circuit; a signal conversion, collection and amplification circuit; signal conversion operating voltage supply and monitoring circuit; signal model/digital conversion, processing, control and temperature sensitivity integrated component; processing result display and storage circuit. For the purpose of increasing stability of biochemical parameter detection, the invention employs method of synchronously measuring detection signal and reference signal to eliminating interference brought by light source and exterior environment change; for the purpose of ensuring efficiency and stability of the instrument for a long time working, the invention realizes a light source monitoring circuit, a signal conversion operating voltage monitoring circuit and so on; synchronously, because environment temperature influences biochemical reaction, the invention employs temperature sensor to realize measurement for environment temperature.
Description
Technical field
The present invention relates to the biochemistry detection technical field, is a kind of portable dry method instrument for quickly detecting optical and biochemical parameters, and it can measure the biochemical parameter as haemoglobin (HB), glutamic-pyruvic transaminase (ALT), specific gravity of urine (SG) etc. based on the optical reflection method.
Background technology
On the clinical medicine and daily health check-up, health care the time often need the biochemical parameter of human body be detected, for clinical diagnosis and health condition evaluation provide reference.And at present, the method for normal employing is to chemically examine to hospital specially.The checkout equipment that Biochemical Lab of hospital uses at present is large-scale bio-chemical detector, as Hitachi 7170, these large-scale bio-chemical detectors detect big in batches, the accuracy height, but need carry out pre-service to test sample, detection time is long, and costs an arm and a leg, so exploitation test sample requirement portable detector few, that testing result can quick and precisely be provided is that market potential is arranged very much.The portable instrument of Liu Tong detection biochemical parameter divides domestic and imported two classes in the market, and the domestic equipment ubiquity that test item is few, the problem of poor accuracy; Therefore import instrument then ubiquity problem of ultra-high price, and strong, the stability of a kind of versatility of design invention, accuracy and high conformity, portable biochemical parameter detecting instrument that cost performance is high are very essential.
Summary of the invention
Purpose of the present invention, provide a kind of portable dry method instrument for quickly detecting optical and biochemical parameters, can detect a plurality of projects, have high stability and accuracy, both can satisfy the requirement that clinical diagnosis and daily life detect aspect accuracy and the consistance, price is lower again, thereby satisfies clinical medicine and people's daily life is convenient to biochemical parameter, the requirement of real-time detection.
For achieving the above object, the technical solution that the present invention adopts provides a kind of portable dry method instrument for quickly detecting optical and biochemical parameters, its based on light reflecting method, have high stability and accuracy; Comprise:
A light path detecting unit, provide for photoelectric commutator provides the photoelectric commutator operating voltage of operating voltage with a light source driving circuit, of controlling light source respectively/observation circuit, is gathered, the signals collecting/amplifying circuit of amplification photoelectric commutator signal variation is electrically connected;
Signals collecting/amplifying circuit, photoelectric commutator operating voltage provide/and the output terminal of observation circuit, environment temperature sensor is electrically connected with analog to digital conversion circuit respectively;
Light source driving circuit, environment temperature sensor and analog to digital conversion circuit are electrically connected with signal controller respectively;
The output terminal of signal controller is electrically connected with memory module, display module, communication module respectively;
One power circuit is connected to above-mentioned each circuit, for each components and parts provides electric energy; It is characterized in that light source driving circuit comprises multiselect one on-off circuit between its electric current output block and a plurality of light source, is used to realize the driving of same circuit to a plurality of light sources; At its current amplitude control end, comprise another multiselect one on-off circuit, the amplitude of the light source drive current of programming thus.
Described fast detecting instrument, its described photoelectric commutator operating voltage provides/observation circuit in, one constant potential reference edge is electrically connected to a differential amplifier positive input terminal, the power circuit positive pole is electrically connected to the negative input end of this differential amplifier through a resistance, this negative input end outputs on the test side and reference edge photoelectric commutator of light path detecting unit again with after output terminal is electrically connected, be used to guarantee that the operating potential of two photoelectric commutators equates with constant potential reference edge current potential, and offer the required marking current of photoelectric commutator.
Described fast detecting instrument, its described signals collecting/amplifying circuit comprises collection/amplifying circuit that two line structures are all identical with device parameters, is used to realize the synchronous acquisition of detection signal and reference signal.
Described fast detecting instrument, in its described signals collecting/amplifying circuit, the photoelectric commutator of light path detecting unit is electrically connected to the negative input end of a differential amplifier, and the positive input terminal of this differential amplifier is electrically connected to power supply with reference on the ground, is used to realize that the operating voltage of photoelectric commutator keeps constant.
The present invention utilizes the optical reflection method that biochemical parameter is tested.Workflow is: the illumination of sending from light source is mapped on the biochemical parameter sensor, the reflected light that contains tested parameter information projects on the electrooptical device and is converted to electric signal, this electric signal is input in the controller after collection, amplification, analog to digital conversion, after data processing,, can detect multiple parameter with testing result demonstration, preservation etc.
The invention has the beneficial effects as follows: the increase of instrument test item, detection accuracy, consistance and stability improve a lot, but cost does not significantly increase than the one-parameter measuring instrument, to compare cost also relatively low with the market like product, thereby cost performance of the present invention is very high.
Description of drawings
Fig. 1 is an one-piece construction block diagram of the present invention;
Fig. 2 is light source drive principle figure of the present invention;
Fig. 3 provides and observation circuit for conversion of signals operating voltage of the present invention;
Fig. 4 is signals collecting of the present invention and amplifying circuit;
Fig. 5 is that controller of the present invention, memory module, display module, communicating circuit and host computer are connected block diagram;
Fig. 6 is communication structure block diagram and this detector function selector circuit of the present invention and host computer;
Fig. 7 is a portable dry method instrument for quickly detecting optical and biochemical parameters software flow pattern of the present invention.
Embodiment
Figure 1 shows that the one-piece construction synoptic diagram of portable dry method instrument for quickly detecting optical and biochemical parameters of the present invention, comprise detecting providing/observation circuit 6, display module 7, light source driving circuit 8, communicating circuit 9 and host computer 10 with sensor 1, light path detecting unit 2, signals collecting/amplifying circuit 3, controller 4, memory module 5, opto-electronic conversion operating voltage.Wherein, detect with biochemical parameter sensor 1 and can be hemochrome (HB) sensor, glutamic-pyruvic transaminase (ALT) sensor, or the sensor that is complementary of other and the present invention.Light path detecting unit 2 places the sample cell top of sensor 1, is provided with several light emitting diodes (LED) 15 and several probes 21 in it.21 1 ends of popping one's head in are electrically connected on the opto-electronic conversion operating voltage and provide/observation circuit 6, and the other end is electrically connected on signals collecting/amplifying circuit 3; Light emitting diode (LED) 15 is electrically connected on light source driving circuit 8 one ends; The other end of signals collecting/amplifying circuit 3 and light source driving circuit 8 is electrically connected with controller 4.Controller 4 also provides with memory module 5, opto-electronic conversion operating voltage/and observation circuit 6, display module 7 and communicating circuit 9 be electrically connected.The other end of communicating circuit 9 is electrically connected with host computer 10.
Light source, i.e. the driving circuit 8 of light emitting diode (LED) 15, specific implementation is as shown in Figure 2.
The specific implementation of signals collecting/amplifying circuit 3 as shown in Figure 4.
The opto-electronic conversion operating voltage provides/specific implementation of observation circuit 6 as shown in Figure 3, wherein Vr is a constant potential.
The specific implementation of communicating circuit 8 as shown in Figure 6, wherein switch 31 is used to select the mode of operation of this detector, promptly selecting normal operating conditions still is detector software upgrading state.
Be example explanation the specific embodiment of the present invention to detect hemochrome (HB) and glutamic-pyruvic transaminase (ALT) below.
Because the light source that the present invention uses is light emitting diode (LED) 15, for improving light source luminescent stability, the invention provides constant current drive mode, promptly adopt the constant current chip to provide drive current for light source.The constant current chip can adopt MAX1916, MAX1561, MAX1570 etc., is preferably MAX1916.Drive principle as shown in Figure 2, the actual drive current of output is determined by resistance 16 during light source chip for driving (MAX1916) 13 work.For realizing software adjustment light source driving current value, the present invention selects for use multiselect one switch 17 to realize resistance (16
1, 16
2..., 16
n) selection.Simultaneously, for realizing the driving of same light source driving circuit to a plurality of light sources, the present invention also selects for use multiselect one switch 14 to realize light source (15
1, 15
2..., 15
n) selection.Multiselect one switch 14 and 17 can realize that the two is preferably triode with analog switch or triode.Present embodiment is because of detecting two kinds of parameters, so the light path detecting unit has used two light sources, resistance 14
1Resistance be defined as 28.8K Ω, resistance 14
2Resistance be defined as 30.2K Ω.Multiselect one switch 14 and 17 is all realized with triode mj13005.The resistance of pull-up resistor 12 is 10K Ω.Operation DC voltage Vs is 5V.
Under the control of light source control end, constant current chip 13 provides steady current according to the resistance size of resistance 16 for light source (LED) 15.When the light source control end is high level, there is steady current to pass through light source (LED) 15, then light source (LED) 15 is in luminance; When the light source control end is low level, there is not electric current to pass through light source (LED) 15, then light source (LED) 15 is in not luminance.
The experiment proved that the luminous intensity of light source (LED) 15 is not only relevant with drive current, also relevant with service time with its environment temperature of living in.For guaranteeing accuracy, stability and the consistance of testing result, must remove light source (LED) 15 luminous intensity variations and testing environment and change the interference that brings.The present invention designs and has realized detection signal and reference signal synchronous acquisition circuit.Because this two-way Acquisition Circuit design and device selection standard are identical, thereby the interference that enters the detection signal end can be reflected by the variation of reference signal end.Simultaneously, by detection, can obtain the operating position of light source (LED) 15, when adopting standard transducer to calibrate and reference signal when being lower than certain value to reference signal, can prove that light source (LED) 15 no longer can satisfy the detection requirement, thereby the prompting user changes new light sources.
Because the signal of light path detecting unit output is a conductance, the present invention designs the technical scheme that has realized gathering with operational amplifier conductance.Because test event is many, the measured matter difference, the intensity of reflected light of sensor also has than big difference, so the conductance signal variation range difference of different detected parameters correspondences is also bigger, for the signal after guarantee amplifying all in the analog to digital conversion effective range, the present invention partly is provided with the amplifier of different multiplying at signal amplification circuit, thereby selects according to the test event difference.Simultaneously also can carry out multistage amplification, improve enlargement ratio.For guaranteeing that the signal enlargement range is in the analog-to-digital effective range, can choose enlargement ratio and number of stages of amplification automatically by software design.Operational amplifier can be selected TLC2264, AD713 etc. for use, is preferably TCL2264.
Signals collecting/amplifying circuit 3 as shown in Figure 4.In Fig. 4, operational amplifier 26
1, 26
2, 26
3The criterion of choosing be: high input impedance, low bias current etc.The TLC2264 operational amplifier that present embodiment selects for use American TI Company to produce.Sampling resistor (22
1, 22
2..., 22
n) the criterion of choosing be that low temperature floats, high precision, it is that 42.2K Ω, precision are 0.1% precision resistance that present embodiment is selected resistance for use.The selection of different sampling resistors among Fig. 4 (being the different enlargement ratios of signal) can realize by analog switch.Present embodiment is fixing enlargement factor.
For accurately gathering the conductance of light path detecting unit output, the present invention is by operational amplifier 26
1The opto-electronic conversion operating voltage is provided/constant voltage that observation circuit 6 provides is converted to current signal with conductance, and this current signal is directly proportional with conductance.Current signal is through sampling resistor (22
1, 22
2..., 22
n) change/be enlarged into voltage signal, this voltage signal is through oppositely, output to mould/number conversion module 4 after isolating
1In.The collection amplifying circuit implementation and the device parameters of detection signal and reference signal are identical.
The opto-electronic conversion operating voltage provides/and observation circuit 6 is as shown in Figure 3.By operational amplifier 19 and current-limiting resistance 18 the opto-electronic conversion operating potential is clamped the current potential in Vr, realize the constant of opto-electronic conversion operating potential thus, and provide required marking current for photoelectric commutator.The present invention adopts the constant voltage chip that Vr is provided current potential, and this constant voltage chip can be selected Ref192, ADR363, ADR364 etc. for use.Be preferably Ref192.Yet along with the detector increase of service time, this opto-electronic conversion operating potential also can produce certain drift.Because this voltage is the key point of signals collecting, thereby its drift will inevitably cause the drift of signal.The present invention adopts this opto-electronic conversion operating potential is outputed to analog-to-digital conversion module 4 after an operational amplifier 20 voltage follows is isolated
1, as Fig. 3 and shown in Figure 5.Through control module 4
2After the calculating, if this voltage drift exceeds accuracy rating, control module 4
2To adjust the signal operation ratio with software, to guarantee the stability and the consistance of testing result. Operational amplifier 19 and 20 selection standard are: high input impedance, low bias current etc.The TLC2264 operational amplifier that present embodiment selects for use American TI Company to produce.The criterion of choosing of current-limiting resistance 18 is that low temperature floats, high precision, and it is 0.1% precision resistance that present embodiment selects for use resistance to be 50K Ω, precision.
Along with the instrument increase of service time, the user may need to increase new software function, is very inconvenient but software upgrading is carried out in the instrument withdrawal, is essential so realize software users from upgrading.The present invention adopts the mode of hardware and software combination to realize this function.At hardware aspect, the present invention by interface 29 and the functional select switch of reserving on TTL/RS232 level transferring chip 28, the meter case 30, realizes the communication of instrument and host computer 10 by the control of controller communication terminal with the RS232 agreement.Specific implementation as shown in Figure 6, when functional select switch 30 disconnected, the mode of operation control end was drawn through pull-up resistor 30 to be high level, detector then is in normal operating conditions, can carry out parameter detecting and carry out data transmission etc. with host computer 10 this moment; When functional select switch 30 closures, the mode of operation control end is drawn to be low level, and detector then is in the downloading mode state, can download new program from host computer 10 this moment and carry out software upgrading.Aspect software,, realize the software upgrade package in the host computer 10 is downloaded to realization instrument software upgrading in the instrument automatically by set up applications on host computer 10.Also the test data of preserving in the instrument can be uploaded and preserves by this application program with certain format.TTL/RS232 level transferring chip 28 can be MAX232, MAX202, GD75232 etc.Be preferably MAX232.Application program is developed under Microsoft VC 6.0 environment.
Among Fig. 6, the TTL/RS232 level transferring chip 22 that the present invention selects for use is MAX232.Functional select switch 31 is common toggle switch.
Software workflow of the present invention as shown in Figure 7.Workflow is: opening power key at first, enter the function selecting menu, select " measurement " menu to enter the test event choice menus, after the selected test event, when sensor is inserted in the LCDs prompting, insert corresponding test event sensor, by beginning countdown behind the acknowledgement key, begin after at the fixed time to measure, finish that the back measurement result is stored and LCDs on show measurement result, can extract sensor out this moment, returns the test event choice menus by any key.
The present invention also provides the measurement result query function.In the function selecting menu, select " record queries " menu to enter the record entry choice menus, after the selected record entry, show this project newest record, according to the keyboard input can be above/turn over record down, withdraw from record demonstration etc.
The present invention adopts decision design on hardware, adopt the menu mode design on software, detect in actual applications respond well, accurately high, stability and high conformity, easy to operate.
Claims (4)
1. portable dry method instrument for quickly detecting optical and biochemical parameters, its based on light reflecting method, have high stability and accuracy; Comprise:
A light path detecting unit, provide for photoelectric commutator provides the photoelectric commutator operating voltage of operating voltage with a light source driving circuit, of controlling light source respectively/observation circuit, is gathered, the signals collecting/amplifying circuit of amplification photoelectric commutator signal variation is electrically connected;
Signals collecting/amplifying circuit, photoelectric commutator operating voltage provide/and the output terminal of observation circuit, environment temperature sensor is electrically connected with analog to digital conversion circuit respectively;
Light source driving circuit, environment temperature sensor and analog to digital conversion circuit are electrically connected with signal controller respectively;
The output terminal of signal controller is electrically connected with memory module, display module, communication module respectively;
One power circuit is connected to above-mentioned each circuit, for each components and parts provides electric energy; It is characterized in that light source driving circuit comprises multiselect one on-off circuit between its electric current output block and a plurality of light source, is used to realize the driving of same circuit to a plurality of light sources; At portable dry method instrument for quickly detecting optical and biochemical parameters current amplitude control end, comprise another multiselect one on-off circuit, the amplitude of the light source drive current of programming thus.
2. fast detecting instrument as claimed in claim 1, it is characterized in that, described photoelectric commutator operating voltage provides/observation circuit in, one constant potential reference edge is electrically connected to a differential amplifier positive input terminal, the power circuit positive pole is electrically connected to the negative input end of this differential amplifier through a resistance, this negative input end outputs on the test side and reference edge photoelectric commutator of light path detecting unit again with after output terminal is electrically connected, be used to guarantee that the operating potential of two photoelectric commutators equates with constant potential reference edge current potential, and offer the required marking current of photoelectric commutator.
3. fast detecting instrument as claimed in claim 1 is characterized in that, described signals collecting/amplifying circuit comprises collection/amplifying circuit that two line structures are all identical with device parameters, is used to realize the synchronous acquisition of detection signal and reference signal.
4. as claim 1 and 3 described fast detecting instrument, it is characterized in that, in described signals collecting/amplifying circuit, the photoelectric commutator of light path detecting unit is electrically connected to the negative input end of a differential amplifier, the positive input terminal of this differential amplifier is electrically connected to power supply with reference on the ground, is used to realize that the operating voltage of photoelectric commutator keeps constant.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100721439A CN100535635C (en) | 2006-04-14 | 2006-04-14 | Portable dry method instrument for quickly detecting optical and biochemical parameters |
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|---|---|---|---|
| CNB2006100721439A CN100535635C (en) | 2006-04-14 | 2006-04-14 | Portable dry method instrument for quickly detecting optical and biochemical parameters |
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| CN101055242A CN101055242A (en) | 2007-10-17 |
| CN100535635C true CN100535635C (en) | 2009-09-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9026386B2 (en) | 2010-11-05 | 2015-05-05 | Yunzhong Jiang | Material property testing devices with capabilities of monitoring energy-consumption and detecting the environment |
| CN102539017A (en) * | 2010-12-15 | 2012-07-04 | 贵州双阳飞机制造厂 | Temperature field measuring device |
| CN104614346B (en) * | 2013-11-05 | 2018-06-01 | 上海阔思电子有限公司 | Recirculated water drug concentration detector |
| CN104407127B (en) * | 2014-12-02 | 2016-07-06 | 深圳中科卉尔立生物科技有限公司 | A kind of dry type body fluid analysis instrument and the method for analysis thereof |
| CN104988061A (en) * | 2015-03-23 | 2015-10-21 | 刘贵忠 | SOD enzyme activity integrating light reaction experimental instrument and applications thereof |
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|---|---|---|---|---|
| US4727033A (en) * | 1981-12-17 | 1988-02-23 | Olympus Optical Co., Ltd. | Analyzing apparatus and method for immunological agglutination reactions |
| US5172696A (en) * | 1989-10-31 | 1992-12-22 | Terumo Kabushiki Kaisha | Photoelectric sphygmomanometer of volume oscillometric method-type |
| CN1356537A (en) * | 2001-12-31 | 2002-07-03 | 天津市先石光学技术有限公司 | Fast tester of blood sugar concentration |
| JP2004251673A (en) * | 2003-02-18 | 2004-09-09 | Bios Ikagaku Kenkyusho:Kk | Optical measuring apparatus and optical measuring method for bio material and chemical substance |
| CN1558240A (en) * | 2004-02-13 | 2004-12-29 | 上海三科仪器有限公司 | Biochemical analyzer applying wet chemical reagent strip |
-
2006
- 2006-04-14 CN CNB2006100721439A patent/CN100535635C/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727033A (en) * | 1981-12-17 | 1988-02-23 | Olympus Optical Co., Ltd. | Analyzing apparatus and method for immunological agglutination reactions |
| US5172696A (en) * | 1989-10-31 | 1992-12-22 | Terumo Kabushiki Kaisha | Photoelectric sphygmomanometer of volume oscillometric method-type |
| CN1356537A (en) * | 2001-12-31 | 2002-07-03 | 天津市先石光学技术有限公司 | Fast tester of blood sugar concentration |
| JP2004251673A (en) * | 2003-02-18 | 2004-09-09 | Bios Ikagaku Kenkyusho:Kk | Optical measuring apparatus and optical measuring method for bio material and chemical substance |
| CN1558240A (en) * | 2004-02-13 | 2004-12-29 | 上海三科仪器有限公司 | Biochemical analyzer applying wet chemical reagent strip |
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