CN100525778C - Novel post-operation antiadhesive materials and its preparation method - Google Patents
Novel post-operation antiadhesive materials and its preparation method Download PDFInfo
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- CN100525778C CN100525778C CNB2004100191683A CN200410019168A CN100525778C CN 100525778 C CN100525778 C CN 100525778C CN B2004100191683 A CNB2004100191683 A CN B2004100191683A CN 200410019168 A CN200410019168 A CN 200410019168A CN 100525778 C CN100525778 C CN 100525778C
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Abstract
The invention discloses a novel post-operation antiadhesive materials and its preparation method, which comprises (by weight ratio) chitosan 10-90, poly anion or poly oxyethylene glycol 90-10.
Description
Technical field
The invention belongs to medical material and preparation method, particularly a kind of novel post-operation adhesion preventing material and preparation method.
Background technology
Tissue adhesion is meant that connective fiber and adjacent tissue or organ combine and the anomalous structure that forms, it is the common clinical picture of surgical operation, also being the inevitable pathophysiological process of postoperative agglutination, is ubiquitous problem at obstetrics, cardiothoracic surgery tissue adhesion.Operation wound, ischemia, hemorrhage and bacterial infection etc. all can cause tissue adhesion.The complication that is caused by peritoneal adhesion mainly comprises intestinal obstruction, infertility and chronic pelvic pain etc., becomes an operating difficult problem.According to statistics, be used for the treatment of the expense of abdominal cavity, pelvic adhesion every year up to about 1,200,000,000 dollars in the U.S..The use of minimally invasive surgery enforcement, Drug therapy and anti isolated material (antiadhesive barrier) etc. all can be played the purpose that reduces adhesion.Wherein, implementing adherence preventing material in the operation is a kind of effective method, has carried out a large amount of clinical experimental studies abroad, has obtained certain achievement.Developed multiple adherence preventing material at present for clinical use, the FDA approved 3 adherence preventing materials, Interceed, Intergel and Seprafilm, wherein Seprafilm clinical research effect is best, but the hyaluronic acid price of using is too high; Two products have now been used seldom in addition.In addition, also have and to assemble the anti that obtains by polyoxyethylene (PEO) and carboxymethyl cellulose (CMC) and touch Oxiplex, politef anti and touch (commodity are called Gore-Tex Surgical Membrane) etc.
Summary of the invention
The invention provides a kind of novel post-operation adhesion preventing material and preparation method: its component and content are following to be by weight percentage:
Chitosan 10-90
Polyanion or Polyethylene Glycol 90-10;
This component constitutes the Antiadhesive film material;
Wherein chitosan can use separately with polyanion or Polyethylene Glycol respectively, also can use with polyanion and PEG, and composite comes from different backgrounds and possess different abilities;
With the polyanion compound tense, can be compound with a kind of polyanion, composite also can come from different backgrounds and possess different abilities with two or more polyanion.
Chitosan and polyanion or (with) the Polyethylene Glycol weight ratio is preferably (10-40): (90-60), or (90-60): (10-40).
Described polyanion is the biologically absorbable polymer material, comprises natural polymer alginate, carboxymethyl starch, carboxymethyl cellulose, gelatin or carrageenan etc.
Novel post-operation adhesion preventing preparation methods of the present invention may further comprise the steps:
1). chitosan is dissolved in the acid solution of 0.1%-5%, is made into the chitosan solution that concentration is 0.5%-6%; Wherein: acid is hydrochloric acid, citric acid, acetic acid or tartaric acid;
2). polyanion is dissolved in is made into the aqueous solution that concentration is 1%-15% in the distilled water; Or Polyethylene Glycol is dissolved in is made into the aqueous solution that concentration is 1%-30% in the distilled water.
With above-mentioned 1) and 2) two solution mix homogeneously, the solution-type adherence preventing material promptly obtained.
In described solution-type adherence preventing material, add the cross-linking agent that accounts for polymer weight 0.001%-0.2%, then obtain the gel-type adherence preventing material; Cross-linking agent is formaldehyde, glutaraldehyde, epoxychloropropane.
With adding the plasticizer that accounts for polymer weight 0.2%-10% in the above-mentioned solution that is added with cross-linking agent, to pour into behind the mixing in the film tool, vacuum drying falls solvent evaporates, then obtains Antiadhesive film; Plasticizer is glycerol or Oleum Ricini.
It is in the 1%-15% aqueous slkali that above-mentioned membrane material is placed on concentration, soaks 1 to 3 hour, and being dipped into pH repeatedly again in distilled water is 5.5-7.5, obtains the Antiadhesive film finished product; Alkali is sodium hydroxide, sodium carbonate, sodium bicarbonate, ammonia or hexamethylenetetramine.
Adherence preventing material Anti Triplex can be film material, gel or solution, and it can reduce tissue adhesion effectively, alleviates patient suffering and financial burden, is a kind of comparatively ideal novel post-operation adhesion preventing method.
The specific embodiment
Example 1 chitosan/carboxymethyl cellulose adherence preventing material
Chitosan is dissolved in 4% acetum, makes the chitosan solution of 5wt%, carboxymethyl cellulose is added in the distilled water, heat, stir the 3wt% cmc soln; With two solution mix homogeneously, obtain the solution-type adherence preventing material; Account for amount of polymers 0.1% glutaraldehyde solution as if adding in solution and make it crosslinked, then obtain the gel-type adherence preventing material; Account for amount of polymers 1% glycerol with being added with to add in the solution of glutaraldehyde, pour into behind the mixing in the film tool, put into vacuum drying oven solvent evaporates is fallen, then obtain Antiadhesive film.Film is placed in 5% the sodium carbonate liquor and soaked 2 hours, being dipped to pH repeatedly with distilled water then is 6.5, obtains the Antiadhesive film finished product.Chitosan/carboxymethyl cellulose weight ratio is 90/10.
Example 2 chitosans/gelatin adherence preventing material
Chitosan is dissolved in 2% citric acid solution, makes the chitosan solution of 5wt%, gelatin is added in the distilled water, heat, stir the 3wt% gelatin solution; With two solution mix homogeneously, obtain the solution-type adherence preventing material then; If in solution, add formalin, make it crosslinked, then obtain the gel-type adherence preventing material; In containing formalin, add glycerol, pour into behind the mixing in the film tool, put into vacuum drying oven solvent evaporates is fallen, then obtain Antiadhesive film.Film is placed in 2% the sodium hydroxide solution and soaked 1 hour, being dipped to pH repeatedly with distilled water then is 5.5, obtains the Antiadhesive film finished product.Chitosan/gelatin weight ratio is 90/10, and formaldehyde accounts for 0.05% of polymer total amount, and amounts of glycerol accounts for 2% of polymer total amount.
Example 3 chitosans/carboxymethyl cellulose (or gelatin)/PEG adherence preventing material
With carboxymethyl cellulose (or gelatin) swelling, dissolving in distilled water, obtain carboxymethyl cellulose (or gelatin) aqueous solution of 5wt%.Chitosan is dissolved in 1% hydrochloric acid solution, makes the chitosan solution of 3wt%.PEG is dissolved in the distilled water, obtains 10%PEG solution.With above-mentioned 3 kinds of solution mix homogeneously, obtain the solution-type adherence preventing material; Make it crosslinked if in solution, add formalin, then obtain the gel-type adherence preventing material; Add glycerol with being added with in the solution of formaldehyde, pour into behind the mixing in the film tool, put into vacuum drying oven solvent evaporates is fallen, then obtain Antiadhesive film.Film is placed in 5% the sodium bicarbonate solution and soaked 3 hours, being dipped to pH repeatedly with distilled water then is 6.8, obtains Antiadhesive film.Chitosan/carboxymethyl cellulose in this Antiadhesive film (or gelatin)/PEG weight ratio is 60/20/20.Formaldehyde accounts for 0.1% of polymer total amount, and amounts of glycerol accounts for 3% of polymer total amount.
Example 4 chitosans/carboxymethyl starch/carrageenan (or gelatin)/PEG adherence preventing material
At first dispose chitosan solution, carrageenan (or gelatin) solution, carboxymethyl starch soln and the 10%PEG solution of 3wt%, then carrageenan (or gelatin) solution and carboxymethyl starch soln are mixed, PEG solution and chitosan solution added successively again, and mix homogeneously, obtain the solution-type adherence preventing material; Make it crosslinked if in solution, add glutaraldehyde solution, then obtain the gel-type adherence preventing material; In containing the solution of glutaraldehyde, add glycerol, pour into behind the mixing in the film tool, put into vacuum drying oven solvent evaporates is fallen, then obtain Antiadhesive film.Film is placed in 5% the ammonia spirit and soaked 2 hours, being dipped to pH repeatedly with distilled water then is 7.5, obtains Antiadhesive film.Chitosan/carboxymethyl starch in this Antiadhesive film/carrageenan (or gelatin)/PEG weight ratio is 60/15/10/15.Glutaraldehyde accounts for 0.15% of polymer total amount, and amounts of glycerol accounts for 5% of polymer total amount.
Example 5 chitosans/PEG adherence preventing material
Chitosan is dissolved in 2% acetum, makes the chitosan solution of 5wt%.PEG is dissolved in the distilled water, obtains 15wt%PEG solution.With above-mentioned 2 kinds of solution mix homogeneously, obtain the solution-type adherence preventing material; Make it crosslinked if in solution, add glutaraldehyde solution, then obtain the gel-type adherence preventing material; Add Oleum Ricini with being added with in the solution of glutaraldehyde, pour into behind the mixing in the film tool, put into vacuum drying oven solvent evaporates is fallen, then obtain Antiadhesive film.Film is placed in 5% the sodium carbonate liquor and soaked 1 hour, being dipped to pH repeatedly with distilled water then is 7, obtains Antiadhesive film.Chitosan in this Antiadhesive film/PEG weight ratio is 60/40, and formaldehyde accounts for 0.3% of polymer total amount, and the Oleum Ricini consumption accounts for 2% of polymer total amount.
Claims (6)
1. post-operation adhesion preventing material, component and content is as follows by weight percentage:
Chitosan 10-90
Polyanion and Polyethylene Glycol 90-10;
This component composite that comes from different backgrounds and possess different abilities;
Chitosan with the polyanion compound tense, with a kind of polyanion compound or with two or more the polyanion composite that comes from different backgrounds and possess different abilities, described polyanion is natural polymer alginate, carboxymethyl starch, carboxymethyl cellulose, gelatin or carrageenan.
2. a kind of post-operation adhesion preventing material as claimed in claim 1, component and content are as follows:
Chitosan 10-40%
Polyanion and Polyethylene Glycol 90-60%.
3. post-operation adhesion preventing preparation methods may further comprise the steps:
1). chitosan is dissolved in the acid solution of 0.1%-5%, is made into the chitosan solution that concentration is 0.5%-6%; Wherein: acid is hydrochloric acid, citric acid, acetic acid or tartaric acid;
2). the polyanion of claim 1 and the solution concentration of distilled water are made into 1%-15%; The solution concentration of Polyethylene Glycol and distilled water is made into 1%-30%;
With above-mentioned 1) and 2) three kinds of solution mix homogeneously, the solution-type adherence preventing material promptly obtained.
4. a kind of post-operation adhesion preventing preparation methods as claimed in claim 3 is characterized in that adding the cross-linking agent that accounts for amount of polymers 0.001%-0.2% in described solution-type adherence preventing material, then obtains the gel-type adherence preventing material; Cross-linking agent is formaldehyde, glutaraldehyde or epoxychloropropane.
5. a kind of post-operation adhesion preventing preparation methods as claimed in claim 4, it is characterized in that in the solution that will be added with cross-linking agent, adding the plasticizer of the 0.2%-10% that accounts for amount of polymers, pour into behind the mixing in the film tool, vacuum drying falls solvent evaporates, then obtains Antiadhesive film; Plasticizer is glycerol or Oleum Ricini.
6. a kind of post-operation adhesion preventing preparation methods as claimed in claim 5 is characterized in that it is in the 1%-15% aqueous slkali that film is placed on concentration, soaks 1-3 hours, and being dipped to pH repeatedly again in distilled water is 5.5-7.5, obtains the Antiadhesive film finished product; Alkali is sodium hydroxide, sodium carbonate, sodium bicarbonate, ammonia or hexamethylenetetramine.
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| CN100525778C true CN100525778C (en) | 2009-08-12 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100415245C (en) * | 2005-08-12 | 2008-09-03 | 天津大学 | Post-surgery anti-accretion material capable of gelatinized in situ or by injection and preparation process thereof |
| CN100434123C (en) * | 2006-02-23 | 2008-11-19 | 暨南大学 | Porous antisticking agar-collagen film and its prepn process |
| CN101601873B (en) * | 2009-07-16 | 2012-10-03 | 浙江大学 | Method for reinforcing modified three-dimensional chitosan rod material by glutaraldehyde crosslinking |
| CN103341217B (en) * | 2013-06-13 | 2015-05-06 | 上海大学 | Preparation method for film used for preventing postoperative tissue adhesion |
| CN106256379A (en) * | 2015-06-18 | 2016-12-28 | 山东美泰医药有限公司 | A kind of bleeding stopping and adherence preventing gauze and preparation method thereof |
| CN108066819B (en) * | 2017-12-01 | 2020-06-05 | 浙江大学 | High-strength natural polymer hydrogel film and preparation method thereof |
| CN109498848B (en) * | 2017-12-25 | 2020-02-07 | 北京百利康生化有限公司 | Absorbable anti-adhesion material used after cardiac surgery and film prepared from same |
| DE102018000009A1 (en) * | 2018-01-04 | 2019-03-07 | PlantTec Medical GmbH | drug |
| CN109481732B (en) * | 2018-12-29 | 2021-07-27 | 中国科学院理化技术研究所 | 3D cell printing material based on PEG chitosan-gelatin system and application thereof |
| CN109880287A (en) * | 2019-03-18 | 2019-06-14 | 山东星火科学技术研究院 | The preparation method of sulfonated polyether-ether-ketone and chitosan complex film |
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2004
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