CN100518724C - Drug releasing membrane controlled by program and its preparation method - Google Patents
Drug releasing membrane controlled by program and its preparation method Download PDFInfo
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- CN100518724C CN100518724C CNB2005100605734A CN200510060573A CN100518724C CN 100518724 C CN100518724 C CN 100518724C CN B2005100605734 A CNB2005100605734 A CN B2005100605734A CN 200510060573 A CN200510060573 A CN 200510060573A CN 100518724 C CN100518724 C CN 100518724C
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- nanoparticle
- particle
- biodegradable polymer
- degradation
- polymer nano
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- 239000003814 drug Substances 0.000 title claims abstract description 42
- 229940079593 drug Drugs 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000012528 membrane Substances 0.000 title claims description 27
- 239000002105 nanoparticle Substances 0.000 claims abstract description 89
- 239000000463 material Substances 0.000 claims abstract description 34
- 238000001179 sorption measurement Methods 0.000 claims abstract description 9
- 229910010272 inorganic material Inorganic materials 0.000 claims abstract description 3
- 239000011147 inorganic material Substances 0.000 claims abstract description 3
- 239000010453 quartz Substances 0.000 claims abstract description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000002210 silicon-based material Substances 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 42
- 229920002988 biodegradable polymer Polymers 0.000 claims description 25
- 239000004621 biodegradable polymer Substances 0.000 claims description 25
- 239000003381 stabilizer Substances 0.000 claims description 25
- 229920001661 Chitosan Polymers 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 15
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 15
- 229920001222 biopolymer Polymers 0.000 claims description 14
- 238000004945 emulsification Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 13
- 229940126586 small molecule drug Drugs 0.000 claims description 12
- 238000004528 spin coating Methods 0.000 claims description 12
- 229920002521 macromolecule Polymers 0.000 claims description 11
- 238000001338 self-assembly Methods 0.000 claims description 11
- 239000002088 nanocapsule Substances 0.000 claims description 9
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 9
- 239000004626 polylactic acid Substances 0.000 claims description 9
- 241001597008 Nomeidae Species 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 7
- 239000003921 oil Substances 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 abstract description 6
- 238000005516 engineering process Methods 0.000 abstract description 4
- 239000000758 substrate Substances 0.000 abstract description 4
- 239000002861 polymer material Substances 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 239000012620 biological material Substances 0.000 description 5
- 239000005517 L01XE01 - Imatinib Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 229940080856 gleevec Drugs 0.000 description 4
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 4
- 239000002775 capsule Substances 0.000 description 3
- 239000010409 thin film Substances 0.000 description 3
- 229920000557 Nafion® Polymers 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
Abstract
Disclosed is a drug releasing film controlled by program and its preparation method, wherein the film comprises biologically degraded polymer nano particles coated with water-soluble micromolecular medicament and biological macromolecular substrate material for adhesion, wherein the substrate material is any one selected from silicon material, quartz material, polymer material and inorganic material, it is in flat plate form or other special-shape, wherein at least one surface is provided with a layer of nano particle layer with electrostatic self-assembling or other hydrogen-link physical adsorption technology.
Description
Technical field
But the present invention relates to a kind of programme-control slow-release bio degradation-type polymer nano-particle thin-film material and preparation method, belong to the drug release preparing technical field.
Background technology
In the prior art, although polymer nano-particle at medicine, chemical industry, electronics, field extensive uses such as coating utilize the Biodegradable polymer to come control drug release also to be in experimental stage at present.Its chief reason is owing to degradation-type polymer price comparison costliness, while sustained release mechanism more complicated, and the difference of drug use purpose in addition causes polymer formulators also to need corresponding adjustment.At present, by the exploitation of biotechnology, the price of degradation-type polymer reduces greatly.By the shape and size of control nanoparticle, we can well control drug release in addition.
Summary of the invention
The purpose of this patent is to overcome the deficiency of above-mentioned existence, and provide a kind of technology of static self assembly of utilizing to realize containing Biodegradable polymer nano-particle and other biological material, promptly be assembled into the drug releasing membrane controlled by program and the preparation method of the ultrathin membrane of irregular part by the Biodegradable polymer nano-particle.
The objective of the invention is to finish by following technical solution: a kind of drug releasing membrane controlled by program, it is made of Biodegradable polymer nano-particle that is inclusive with the soluble small molecular medicine and bonding biopolymer baseplate material, described baseplate material is at least a in silicon materials, quartz material, polymeric material, the inorganic material, be tabular or other other shaped, utilize static self assembly or other hydrogen bond physical adsorption techniques to be compounded with one deck nanoparticle layers at least on its at least one surface.
Described nanoparticle layers is made up of the Biodegradable polymer nano-particle that is inclusive with the soluble small molecular medicine, this nanoparticle is to be made of degradation-type macromolecule and surface stabilizer macromole and soluble small molecular medicine, wherein the degradation-type macromolecule be polylactic acid with and derivant or chitosan with and its derivant; Surface stabilizer is by nonionic molecules surfactant and other polyelectrolyte mixture.
The high molecular weight percent proportioning of degradation-type was 85--95% during described Biodegradable polymer nano-particle was formed, and the weight percent proportioning of surface stabilizer is 5-15%; And the soluble small molecular medicine is sealed in the described nanoparticle that is made of degradation-type macromolecule and surface stabilizer macromole, and the solids content of small-molecule drug in nanoparticle is 1～10%.
Described degradation-type macromolecule be at least polylactic acid with and derivant, the surface stabilizer macromole is at least the mixture of polyvinyl alcohol and chitosan, and polylactic acid with and the weight percent proportioning of derivant be 90%, the weight percent proportioning of the mixture of polyvinyl alcohol and chitosan is 10%.
In the mixture of described polyvinyl alcohol and chitosan, the weight percent proportioning of polyvinyl alcohol is 50-90%, and the weight percent proportioning of chitosan is 10-50%.
Bonding biopolymer baseplate material of the present invention is a biocompatible material, and containing polyfunctional group is charged group, hydroxyl or amido.
A kind of preparation is the method for drug releasing membrane controlled by program as mentioned above, it comprises: the 1) preparation of nanoparticle: degradation-type macromole and small-molecule drug mix by prescription, form water in oil structure, obtain milky solution through stirring after one hour, by crossing the method for ultrasonic emulsification, the nanoparticle that obtains; This nanoparticle is poured into rapidly in the water that contains surface stabilizer; By the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle or capsule again; 2) nanoparticle surface modified, carry out grafting or adsorption function group; 3) utilize spin coating method and make Biodegradable polymer nano-particle or capsule form nanoparticle layers according to the method for self assembly layer by layer; The concentration of particle is 10
10～10
16Particle/milliliter, built-up time are 10 minutes; 4) utilize spin coating method that bonding biopolymer baseplate material is modified at the nanoparticle laminar surface, and the concentration of bonding biomaterial be 2 mMs/liter, built-up time is 10 minutes; 5) obtain different composite-like nanometer diverse structure ultrathin membrane materials as required.
Described Biodegradable polymer nano-particle reacts in the solvent as the hypotoxicity dichlorotoleune, is distributed to water then and prepares nanoparticle.
Described nanometer diverse structure ultrathin membrane material, thickness between 200 nanometers to 1 millimeter, the speed of drug release can be controlled at 1 nanogram/hour to 100 micrograms/hour.
The present invention utilizes the ultrathin membrane that the Biodegradable polymer nano-particle is assembled into irregular part at ambient temperature, and this nano hybridization diverse structure ultrathin membrane can effectively carry out drug release by programme-control.This ultrathin nanometer thickness of structure can minimumly be controlled at below 200 nanometers, the highlyest can reach more than the millimeter; The Stability Analysis of Structures of ultrathin membrane, drug release can optimal controls, and material can be applied to human body.
The present invention is modified on the surface of baseplate material by the method for the self assembly nanoparticle of will degrading, and by repeatedly repeating absorption, can accurately control the quantity of absorption and the thickness of thin film; Characteristics such as this ultrathin membrane material can be applied in stent and other medical bolt section bar material, and it is simple that it has preparation technology, easy to use, and cost of manufacture is low, and is safe, practical, and application is wide, it has very application prospects for drug release.
The specific embodiment
The present invention will be described in detail below in conjunction with embodiment:
Embodiment 1:1) the weight percent proportioning that to get the high molecular weight percent proportioning of degradation-type be 85--95%, surface stabilizer is 5-15% as the capsular container of slow-release medicine; Get with the proportioning of above-mentioned container at 1～10% small-molecule drug, as the Gleevec medicine, the soluble small molecular medicine is sealed in the described nanoparticle container that is made of degradation-type macromolecule and surface stabilizer macromole.Degradation-type macromole and small-molecule drug are mixed by proportioning, form water in oil structure, obtain milky solution after one hour, by the method for ultrasonic emulsification, obtain nanoparticle again through stirring; This nanoparticle is poured into rapidly in the water that contains surface stabilizer, this surface stabilizer is made up of the polyvinyl alcohol of weight percent proportioning 50-90% and 10-50% chitosan mixing of weight percent proportioning, by the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle capsule again; 2) nanoparticle surface modified, carry out grafting or adsorption function group; 3) utilize spin coating method and make Biodegradable polymer nano-particle or capsule form nanoparticle layers according to the method for self assembly layer by layer; The concentration of particle is 10
10～10
16Particle/milliliter, built-up time are 10 minutes; 4) utilize spin coating method that bonding biopolymer baseplate material is modified at the nanoparticle laminar surface, and the concentration of bonding biomaterial be 2 mMs/liter, built-up time is 10 minutes; 5) obtain different composite-like nanometer diverse structure ultrathin membrane materials as required.
Biodegradable polymer nano-particle of the present invention reacts in the solvent as the hypotoxicity dichlorotoleune, is distributed to water then and prepares nanoparticle.
Nanometer diverse structure ultrathin membrane material of the present invention, thickness between 200 nanometers to 1 millimeter, the speed of drug release can be controlled at 1 nanogram/hour to 100 micrograms/hour.
Embodiment 2:1) get that the high molecular weight percent proportioning of degradation-type is 85%, the weight percent proportioning of surface stabilizer is 15% as the capsular container of slow-release medicine; Get with the proportioning of above-mentioned container at 1% small-molecule drug, as the Gleevec medicine, the soluble small molecular medicine is sealed in the described nanoparticle container that is made of degradation-type macromolecule and surface stabilizer macromole.Degradation-type macromole and small-molecule drug are mixed by prescription, form water in oil structure, obtain milky solution after one hour, by the method for ultrasonic emulsification, obtain nanoparticle again through stirring; This nanoparticle is poured into rapidly in the water that contains surface stabilizer, this surface stabilizer is mixed by weight percent proportioning 50% polyvinyl alcohol and weight percent proportioning 50% chitosan and forms, by the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle capsule again; 2) nanoparticle surface modified, carry out grafting or adsorption function group; 3) utilize spin coating method and make Biodegradable polymer nano-particle or capsule form nanoparticle layers according to the method for self assembly layer by layer; The concentration of particle is 10
10～10
16Particle/milliliter, built-up time are 10 minutes; 4) utilize spin coating method that bonding biopolymer baseplate material is modified at the nanoparticle laminar surface, and the concentration of bonding biomaterial be 2 mMs/liter, built-up time is 10 minutes; 5) obtain different composite-like nanometer diverse structure ultrathin membrane materials as required.
Embodiment 3:1) get that the high molecular weight percent proportioning of degradation-type is 95%, the weight percent proportioning of surface stabilizer is 5% as the capsular container of slow-release medicine; Get with the proportioning of above-mentioned container at 10% small-molecule drug, as the Gleevec medicine, the soluble small molecular medicine is sealed in the described nanoparticle container that is made of degradation-type macromolecule and surface stabilizer macromole, degradation-type macromole and small-molecule drug are mixed by prescription, form water in oil structure, obtain milky solution through stirring after one hour, by the method for ultrasonic emulsification, obtain nanoparticle again; This nanoparticle is poured into rapidly in the water that contains surface stabilizer, this surface stabilizer is mixed by weight percent proportioning 90% polyvinyl alcohol and weight percent proportioning 10% chitosan and forms, by the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle capsule again; 2) nanoparticle surface modified, carry out grafting or adsorption function group; 3) utilize spin coating method and make Biodegradable polymer nano-particle or capsule form nanoparticle layers according to the method for self assembly layer by layer; The concentration of particle is 10
10～10
16Particle/milliliter, built-up time are 10 minutes; 4) utilize spin coating method that bonding biopolymer baseplate material is modified at the nanoparticle laminar surface, and the concentration of bonding biomaterial be 2 mMs/liter, built-up time is 10 minutes; 5) obtain different composite-like nanometer diverse structure ultrathin membrane materials as required.
Embodiment 4: will contain 500 milligrams of the solution of water 2 gram of Gleevec 30mg and dissolving polylactic acid behind 10 milliliters of mix homogeneously of dichloromethane, with ultrasonic 2 to 10 minutes of the method for ultrasonic emulsification, the nanoparticle that will obtain white was dispersed in the organic solvent.This solution is poured in water 30 grams that contain 300 milligrams of 300 milligrams of polyvinyl alcohol and chitosans, continued to stir after 1 hour, will obtain the water soluble nanometer particles of white with ultrasonic 2 to 10 minutes of the method for ultrasonic emulsification.
This nanoparticle surface is owing to there is the existence of chitosan to present positive charge.
Get surface-functionalized substrate, the method for utilizing absorption layer by layer is modified at nanoparticle and the adhesion type biopolymer method by the static self assembly on the substrate.The concentration of nanoparticle or adhesion type biopolymer (Nafion or chitosan etc.) is not very important to the influential effect of absorption, but needs the adhesion type biopolymer effectively nanoparticle to be adsorbed on the surface.By the number of plies of control assembling, the thickness of film of nanoparticles can be regulated and control to 300 nanometers between 1300 nanometers.By detect this drug release rate that comprises the nano thin-film of small-molecule drug can control to 1 nanogram/hour.Programme-control can be regulated by different pH value, in acidity very strong (pH=3) rate of release can control to 1000 nanograms/hour.
Also can adopt following component proportioning among other embodiment of the present invention:
Component proportioning 1: 500 milligrams of polylactic acid; 10 milliliters of dichloromethane; 300 milligrams of polyvinyl alcohol; 300 milligrams of chitosans; Water 30 grams.
Component proportioning 2; Glevec 30mg; 500 milligrams of polylactic acid; 20 milliliters of dichloromethane; 1200 milligrams of polyvinyl alcohol; 300 milligrams of chitosans; Water 30 grams.
Component proportioning 3: nanoparticle (component proportioning 2); 3 bilayers of ultrathin membrane (nanoparticle/nafion); Thickness 120 nanometers; Time rate of release 1 nanogram/hour
Component proportioning 4: nanoparticle (component proportioning prescription 2); 10 bilayers of ultrathin membrane (nanoparticle/modification of chitosan); Thickness 300 nanometers; Unit interval rate of release 100 nanograms/hour.
Claims (6)
1, a kind of drug releasing membrane controlled by program, it is made of Biodegradable polymer nano-particle that is inclusive with the soluble small molecular medicine and bonding biopolymer baseplate material, described baseplate material is at least a in silicon materials, quartz material, polymeric material, the inorganic material, be tabular or other other shaped, utilize static self assembly or other hydrogen bond physical adsorption techniques to be compounded with one deck nanoparticle layers at least on its at least one surface; Described nanoparticle layers is made up of the Biodegradable polymer nano-particle that is inclusive with the soluble small molecular medicine, this nanoparticle is to be made of degradation-type macromolecule and surface stabilizer macromole and soluble small molecular medicine, wherein the degradation-type macromolecule be polylactic acid with and derivant or chitosan with and derivant; The surface stabilizer macromole is at least the mixture of polyvinyl alcohol and chitosan.
2, drug releasing membrane controlled by program according to claim 1, it is characterized in that the high molecular weight percent proportioning of degradation-type is 85--95% in the Biodegradable polymer nano-particle composition, the macromolecular weight percent proportioning of surface stabilizer is 5-15%; And the soluble small molecular medicine is sealed in the described nanoparticle that is made of degradation-type macromolecule and surface stabilizer macromole, and the solids content of small-molecule drug in nanoparticle is 1～10%.
3, drug releasing membrane controlled by program according to claim 1 and 2, it is characterized in that described degradation-type macromolecule be polylactic acid with and derivant, the surface stabilizer macromole is the mixture of polyvinyl alcohol and chitosan, and polylactic acid with and the weight percent proportioning of derivant be 90%, the weight percent proportioning of the mixture of polyvinyl alcohol and chitosan is 10%.
4, drug releasing membrane controlled by program according to claim 3 is characterized in that in the mixture of described polyvinyl alcohol and chitosan that the weight percent proportioning of polyvinyl alcohol is 50-90%, and the weight percent proportioning of chitosan is 10 one 50%.
5, a kind of preparation is as the method for drug releasing membrane controlled by program as described in claim 1 or 2 or 3 or 4, this method is: the 1) preparation of nanoparticle: degradation-type macromole and small-molecule drug mix by prescription, form water in oil structure, obtain milky solution through stirring after one hour, by the method for ultrasonic emulsification, the nanoparticle that obtains; This nanoparticle is poured into rapidly in the water that contains surface stabilizer; By the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle or capsule again; 2) nanoparticle surface modified, carry out grafting or adsorption function group; 3) utilize spin coating method and make Biodegradable polymer nano-particle or capsule form nanoparticle layers according to the method for self assembly layer by layer; The concentration of particle is 10
10～10
16Particle/milliliter, built-up time are 10 minutes; 4) utilize spin coating method that bonding biopolymer baseplate material is modified at the nanoparticle laminar surface, and the concentration of bonding biopolymer baseplate material be 2 mMs/liter, built-up time is 10 minutes; 5) obtain different composite-like nanometer diverse structure ultrathin membrane materials as required; It is characterized in that: described Biodegradable polymer nano-particle reacts in the solvent of hypotoxicity dichlorotoleune, is distributed to water then and prepares nanoparticle.
6, a kind of preparation is as the method for drug releasing membrane controlled by program as described in claim 1 or 2 or 3 or 4, this method is: the 1) preparation of nanoparticle: degradation-type macromole and small-molecule drug mix by prescription, form water in oil structure, obtain milky solution through stirring after one hour, by the method for ultrasonic emulsification, the nanoparticle that obtains; This nanoparticle is poured into rapidly in the water that contains surface stabilizer; By the method for ultrasonic emulsification, obtain Biodegradable polymer nano-particle or capsule again; 2) nanoparticle surface modified, carry out grafting or adsorption function group; 3) utilize spin coating method and make Biodegradable polymer nano-particle or capsule form nanoparticle layers according to the method for self assembly layer by layer; The concentration of particle is 10
10～10
16Particle/milliliter, built-up time are 10 minutes; 4) utilize spin coating method that bonding biopolymer baseplate material is modified at the nanoparticle laminar surface, and the concentration of bonding biopolymer baseplate material be 2 mMs/liter, built-up time is 10 minutes; 5) obtain different composite-like nanometer diverse structure ultrathin membrane materials as required; It is characterized in that described nanometer diverse structure ultrathin membrane material, thickness between 200 nanometers to 1 millimeter, the speed of drug release can be controlled at 1 nanogram/hour to 100 micrograms/hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100605734A CN100518724C (en) | 2005-08-29 | 2005-08-29 | Drug releasing membrane controlled by program and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100605734A CN100518724C (en) | 2005-08-29 | 2005-08-29 | Drug releasing membrane controlled by program and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1732907A CN1732907A (en) | 2006-02-15 |
| CN100518724C true CN100518724C (en) | 2009-07-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100605734A Expired - Fee Related CN100518724C (en) | 2005-08-29 | 2005-08-29 | Drug releasing membrane controlled by program and its preparation method |
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| Country | Link |
|---|---|
| CN (1) | CN100518724C (en) |
-
2005
- 2005-08-29 CN CNB2005100605734A patent/CN100518724C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 聚合物纳米粒子用于给药载体. 查刘生等.高分子通报，第3期. 2002 |
| 聚合物纳米粒子用于给药载体. 查刘生等.高分子通报，第3期. 2002 * |
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| Publication number | Publication date |
|---|---|
| CN1732907A (en) | 2006-02-15 |
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