CN100500232C - A filter for the removal of substances from blood products - Google Patents
A filter for the removal of substances from blood products Download PDFInfo
- Publication number
- CN100500232C CN100500232C CNB2004800275672A CN200480027567A CN100500232C CN 100500232 C CN100500232 C CN 100500232C CN B2004800275672 A CNB2004800275672 A CN B2004800275672A CN 200480027567 A CN200480027567 A CN 200480027567A CN 100500232 C CN100500232 C CN 100500232C
- Authority
- CN
- China
- Prior art keywords
- defecator
- polymer
- fiber
- hydrophobic
- polyamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
- A61M1/3686—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents by removing photoactive agents after irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
Abstract
A filter device for the depletion of the leukocyte content from blood products comprising: a porous element comprising at least one fibrous web having a pore size suitable for leukocyte removal (possibly the range for the pore size should be defined), said web comprising fibres of a hydrophobic polymer coated with a hydrophilic polymer suitable to enhance the CWST of said hydrophobic polymer, characterised in that said web further includes adsorbent particles having a mean diameter lower than 30 m, said particles being bonded to said fibres by means of said hydrophilic polymer coating said fibres.
Description
The present invention relates to a kind of leukocytic filter of from blood or blood constituent, removing, relate more specifically to a kind of leucocyte filter that is applicable to the blood purification devices, as be generally used for making the blood bag system of the blood component that the separation of whole blood leukoblast removes.
The blood filter that this invention relates to typically comprises having the input and the body of output port, and multihole device at least, and it inserts between input and the output port at internal body.
This multihole device is made of the net that can be formed by the filtering material of single or multiple lift usually, typically is adhesive-bonded fabric.
According to prior art, multihole device can be made with material blood compatibility by any, and this material is wanted to form fiber, comprises natural and synthetic fibers.
Preferable material is a synthetic polymer, as particularly polyolefin, polyester and polyamide.
The fiber leucocyte filter is well-known in the prior art, for example is described in EP-A-0313 348 and EP-A-0 397 403.
The preferable material that is used for leucocyte filter is a synthetic resin, and it is suitable for being processed to very thin fiber (diameter preferably is lower than 3 microns) by melting the body injection.
The preferable material of using at present is polybutylene terephthalate (PBT).Thereby surface characteristic that can this employed fibrous material of modification increases its wettability, or its critical wetted surface tension force (CWST), and this is to weigh the hydrophilic yardstick of material.
For this reason, the hydrophobic resin fiber, as PBT, coated a kind of more hydrophilic polymer, as especially, hydrophilic acrylate copolymer or copolymer or hydrophilic polyurethane.
The polymeric material that is used for fiber also can become more hydrophilic, this is by making polymeric material, PBT particularly, with contain alkene class unsaturated group as with the bonded acrylate moiety of hydroxyl or methacrylate or methylmethacrylate and its bonded chemical compound surface grafting, as be described in EP-A-0 313 348.
In general, the filter with high-hydrophilic improves hematoblastic recovery, described in US 5 580465 and US4 618 533.
The also known compound leucocyte filter of prior art comprises polymer fiber and solid particle, increases the total surface area of filtering material.
US 5 454 946 has described the leukocytic filtering material of a kind of filtration, comprise the net of being made by two screw thread matrix fibers (interlocked matrix fibres), this matrix fiber is mainly by glass fibre and place the fibrillation granule of the textile fiber material in substrate gap to constitute.A kind of thermoplastic binder is positioned over the cross section of matrix fiber.This fibrillation granule does not have characterization of adsorption, and is not porous in nature.
US 6 337 026 has described a kind of filter medium that is used for the US 5 454 946 described types of leukocyte depletion equally, and wherein granule has the 100m of being at least
2The very high specific surface area of/g, and the weight ratio of granule and matrix fiber is less than 100.
US 2,001,/00 09756 A1 have described a kind of device that is used for reducing biological composition low molecular weight compound concentration, and it comprises a kind of inert base that comprises absorbability particle.This can removed chemical compound, its molecular weight to about 30000g/mol, has comprised pathogen inactivated reagent such as photoactivation product, aminacrine, organic dyestuff and phenothiazine from 100g/mol.This device is described to be used for leukocyte depletion.
The invention provides a kind of filtering material and defecator, it has also obtained high efficiency except removing low molecular weight compound from blood products and whole blood or blood constituent in leukocytic removal.
Theme of the present invention limits in appended claims.
Constitute this defecator of subject matter, have multihole device, this element has comprised that at least one its pore size is fit to the fleece of leucocyte removal.Described net contains hydrophobic polymer fibers, and it is by being suitable for increasing critical wetting surface tension (CWST) or the hydrophilic hydrophilic polymer of described hydrophobic polymer to small part is coated with.The hydrophobic polymer that is suitable for comprises polyolefin, as polyethylene and polypropylene, and polyamide, Nomex, polyacrylic, polyacrylonitrile (polyacrilonitriles), cellulose acetate, poly-inclined to one side vinylidene fluoride and polyesters.Preferred polymer is polybutylene terephthalate (PBT).
The scope of network fiber diameter is spun generally at 0.01 micron to 5 microns by unit.
Produce the preferred technology of this non woven random net for melting the body spraying technique.Utilize this technology, the inner porous and the distribution of fiber diameters of fabric all can be by technological parameters, as spinning head character and setting, D.C.D. (Distance Conveyor to Die), hot-air and polymer output, technological temperature, the suction of catcher and location (as gradient) determined.
Adsorption particle is combined on the fibre substrate, makes them when contacting with biofluid, can not be released in static or flow condition.The absorption microparticle that is used for filter of the present invention comprises the microparticle of being made by biocompatible materials or be coated with biocompatible materials to small part.Be applicable to that absorbability particle or the globule of removing toxin from blood or blood plasma are known in the prior art.They comprise polymeric material, as polyacrylic, and polyester, polyamide, polyacrylamide and polystyrene copolymer; Preferable material is polystyrene divinylbenzene (DVB) or polyamide.Also can adopt active carbon.The diameter of these granules or globule can change on a large scale, is generally 0.1 to 200 micron.Yet, especially preferably use average diameter less than 30 microns granule.Also expection uses specific surface area to be higher than 200m within the scope of the invention
2/ g is to about 800m
2/ g or more have intrinsic (internal) micro porous microparticle.
The hydrophilic hydrophilic polymer that is used to improve hydrophobic fiber is preferably selected from by vinyl acetate (VA) and vinylpyrrolidone (VP) with different mol ratio, as VA/VP=50/4, and the copolymer that polymerization obtains.
Adsorption particle can as by heat treatment, include the surface that method (inclusion method) and coating are incorporated into fiber by several methods known in the art.Yet according to this invention, preferable methods is to utilize identical being used to improve the hydrophilic hydrophilic polymer of fibrous material to be coated with.According to this preferable methods, flood or soak into the porous net of hydrophobic fiber (preferred PBT) with the solution of selected hydrophilic polymer, described solution comprise described polymer solvent (as alcoholic solvent) and fast adsorption particle suspend wherein.Particulate amount in concentration by hydrophilic polymer in the suitable selection solution and the solution, when drying like this may obtain a kind of filtering material during the net of dipping, wherein, absorbability particle is attached to fiber surface, and fiber surface and particle surface to small part is coated with hydrophilic polymer.Found that this coating can not damage the characterization of adsorption of absorbability particle.In this method, preferably, hydrophilic polymer, mentioning as the front and to be preferably polyvinylpyrrolidone, is that 0.1-5wt% is used for dipping solution with concentration, and adsorption particle, preferably make with polystyrene-DVB or polyamide, with 0.5-10wt%, the amount of preferred 0.1-10wt% adds solution.
Usually the amount that is attached to the adsorption particle on the fleece is 0.01 to the 0.5g/g net, is preferably 0.1 to 0.5g/g.
The overall porosity of filtering material of the present invention is the diameter by fiber, and the size of microparticle and the distribution of microparticle and concentration decide.So, by utilizing microparticle, can reduce the porosity of material, with the efficient (not needing obviously to change the initial properties (as thickness) of fibrous material) that increases the filter leukocyte depletion thus optimized its final distribute (final profile).
By utilizing adsorption particle, especially have the polystyrene-DVB or the polyamide granules of high surface.Filtering material of the present invention also can be removed low molecular weight substance such as dyestuff and photolytic activity molecule such as antiviral reinforcing agent from blood or blood products, methylene blue (metyleneblue), acridine (acrydinyl) derivant, psoralen and psoralen derivant.
Embodiment 1: filter of being made by new material and the filter of being made by traditional material are compared.
To compare with new filtering material whole blood (WB) filter of making and the filter of making by conventional filter material.
Filtering material according to the present invention is made by the nonwoven web of PBT fiber, and it is coated with polyvinylpyrrolidone, and contains the bonded polyamide granules that average diameter is about 12 microns, and granule content is about 0.4g/g net.
Each filter all is to be made by 30 layers of this novel filter material.
The traditional filtering modulator material is that net spins in the unit of PBT, and it is used and the identical polyvinylpyrrolidonesolution solution coating that is used for novel filter material.
WB filter with conventional filter material, a kind of situation are to make by 40 layers, and another kind of situation is to make by 30 layers.
Deriving from random, blood donor's whole blood (from 450-550ml) is collected in the PVC bag with 70mlCPD.All golden blood is contributed product and be cooled to 20-24 ℃ under 1,4 butanediol plate.Filter by gravity.
Complete blood cell in the blood that is filtered (WBC) is counted by the Nageotte hemocytometer.
The result who is obtained is summarized as follows table:
These experimental results illustrate that new filtering material is more efficient to leukocytic removing, and material still less obtains the result identical with conventional filter thereby it allows utilization.
Embodiment 2: remove acridine derivatives from RCC
Make filter by new filtering material as described in example 1 above, utilize the PS-DVB microsphere, its consumption is the 0.4g/g net.
The average diameter of microsphere is 35 microns, and its surface area is 900m
2/ g.30 layers of this material are used to make filter.
Acridine derivatives is added in the sack of the RCC (Vol.=270ml) that contains SAG-M to obtain the acridine derivatives of 200 micro-molar concentrations (micromol).
Filtration is realized that by gravity the content that filters the back acridine derivatives is less than 1 micro-molar concentration (micromolar).
Do not remove acridine derivatives with conventional filter (40 layers).
Claims (26)
1. from blood products, remove the defecator of leukocyte content, comprising:
-multihole device comprises that at least one has the fleece of the pore size of suitable leucocyte removal,
-described net contains hydrophobic polymer fibers, and it is by the tensile hydrophilic polymer coating of the critical wetted surface that is suitable for increasing described hydrophobic polymer,
It is characterized in that described net also comprises average diameter less than 30 microns adsorption particle, described granule is attached to described fiber by the mode that described hydrophilic polymer is coated with described fiber.
2. according to the defecator of claim 1, wherein said Netcom crosses with described hydrophilic polymer solution and soaks into described hydrophobic polymer fibers net and obtain, and contains the described adsorption particle of suspension in the described solution.
3. according to the defecator of claim 2, wherein said solution comprises the described granule of 0.1-10wt%.
4. according to the defecator of claim 1, wherein said hydrophilic polymer is selected from by vinyl acetate and vinylpyrrolidone polymerization and the copolymer that obtains.
5. according to each defecator in the claim 1 to 4, wherein said adsorption particle is by being selected from acrylate copolymer, polyester, and polyamide, polyacrylamide, the material of active carbon and polystyrene divinylbenzene is made.
6. according to each defecator in the claim 1 to 4, wherein said hydrophobic polymer is selected from polyethylene, polypropylene, cellulose acetate, polyamide, acrylate copolymer, polyacrylonitrile, poly-inclined to one side vinylidene fluoride, Nomex and polyester.
7. according to each defecator in the claim 1 to 4, wherein said hydrophobic polymer is a polybutylene terephthalate.
8. according to the defecator of claim 5, wherein said hydrophobic polymer is selected from polyethylene, polypropylene, cellulose acetate, polyamide, acrylate copolymer, polyacrylonitrile, poly-inclined to one side vinylidene fluoride, Nomex and polyester.
9. according to the defecator of claim 5, wherein said hydrophobic polymer is a polybutylene terephthalate.
10. according to each defecator in the claim 1 to 4, wherein said net comprises that particulate amount is the 0.01-0.5g/g web material.
11. according to the defecator of claim 5, wherein said net comprises that particulate amount is the 0.01-0.5g/g web material.
12. according to the defecator of claim 6, wherein said net comprises that particulate amount is the 0.01-0.5g/g web material.
13. according to the defecator of claim 7, wherein said net comprises that particulate amount is the 0.01-0.5g/g web material.
14. defecator according to Claim 8, wherein said net comprise that particulate amount is the 0.01-0.5g/g web material.
15. according to the defecator of claim 9, wherein said net comprises that particulate amount is the 0.01-0.5g/g web material.
16. according to each defecator in the claim 1 to 4, wherein hydrophobic polymer is a polybutylene terephthalate, adsorption particle is made by polyamide or polystyrene divinylbenzene polymer, and is attached on the hydrophobic fiber by the mode that polyvinylpyrrolidone to small part is coated with described fiber.
17. defecator according to claim 5, wherein hydrophobic polymer is a polybutylene terephthalate, adsorption particle is made by polyamide or polystyrene divinylbenzene polymer, and is attached on the hydrophobic fiber by the mode that polyvinylpyrrolidone to small part is coated with described fiber.
18. defecator according to claim 6, wherein hydrophobic polymer is a polybutylene terephthalate, adsorption particle is made by polyamide or polystyrene divinylbenzene polymer, and is attached on the hydrophobic fiber by the mode that polyvinylpyrrolidone to small part is coated with described fiber.
19. defecator according to Claim 8, wherein hydrophobic polymer is a polybutylene terephthalate, adsorption particle is made by polyamide or polystyrene divinylbenzene polymer, and is attached on the hydrophobic fiber by the mode that polyvinylpyrrolidone to small part is coated with described fiber.
20. defecator according to claim 10, wherein hydrophobic polymer is a polybutylene terephthalate, adsorption particle is made by polyamide or polystyrene divinylbenzene polymer, and is attached on the hydrophobic fiber by the mode that polyvinylpyrrolidone to small part is coated with described fiber.
21. defecator according to claim 11, wherein hydrophobic polymer is a polybutylene terephthalate, adsorption particle is made by polyamide or polystyrene divinylbenzene polymer, and is attached on the hydrophobic fiber by the mode that polyvinylpyrrolidone to small part is coated with described fiber.
22. defecator according to claim 12, wherein hydrophobic polymer is a polybutylene terephthalate, adsorption particle is made by polyamide or polystyrene divinylbenzene polymer, and is attached on the hydrophobic fiber by the mode that polyvinylpyrrolidone to small part is coated with described fiber.
23. defecator according to claim 14, wherein hydrophobic polymer is a polybutylene terephthalate, adsorption particle is made by polyamide or polystyrene divinylbenzene polymer, and is attached on the hydrophobic fiber by the mode that polyvinylpyrrolidone to small part is coated with described fiber.
24. remove the method for material from blood products for one kind, it comprises makes described blood products by according to each defecator charging among the claim 1-23.
25. a blood purification devices, it comprises according to each defecator among the claim 1-23.
26. blood purification devices according to claim 25, its blood bagging apparatus by the blood component that is used for the blood separation leukoblast is removed constitutes, comprise by according among the claim 1-23 each defecator with second bag with fluid flow communication mode was connected first bag.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03021435.7 | 2003-09-23 | ||
| EP03021435A EP1518573B1 (en) | 2003-09-23 | 2003-09-23 | Filter, purification device and method for the removal of substances from blood products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1856332A CN1856332A (en) | 2006-11-01 |
| CN100500232C true CN100500232C (en) | 2009-06-17 |
Family
ID=34178476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004800275672A Expired - Fee Related CN100500232C (en) | 2003-09-23 | 2004-09-22 | A filter for the removal of substances from blood products |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7524425B2 (en) |
| EP (1) | EP1518573B1 (en) |
| JP (1) | JP4491460B2 (en) |
| CN (1) | CN100500232C (en) |
| AT (1) | ATE337036T1 (en) |
| DE (1) | DE60307849T2 (en) |
| ES (1) | ES2268245T3 (en) |
| WO (1) | WO2005028003A1 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5769418B2 (en) | 2007-08-31 | 2015-08-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Selective cell adsorption removal apparatus and related method |
| DE102009006583A1 (en) * | 2009-01-29 | 2010-06-17 | Neenah Gessner Gmbh | Multi-layer filter material for liquid filtration, for manufacturing filter element, has three layers, where former layer is of wet fleece made of cellulose or synthetic fibers or mixture |
| KR20120006036A (en) * | 2009-04-07 | 2012-01-17 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Improved sorbent loaded webs for gravity filtration |
| AU2011315839B2 (en) | 2010-10-15 | 2016-02-18 | Seastar Medical Inc. | Cytopheresic cartridge and use thereof |
| WO2013106109A1 (en) | 2012-01-09 | 2013-07-18 | Humes, H., David | Cartridge and method for increasing myocardial function |
| CN105555382A (en) * | 2013-04-25 | 2016-05-04 | 离体动力学公司 | Non-hemolyzing blood filter and methods for filtering blood without hemolysis |
| US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
| US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
| US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
| US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
| US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
| WO2015160392A1 (en) | 2014-04-16 | 2015-10-22 | Cummins Filtration Ip, Inc. | Tuning surface properties of melt blown polyester fibers by hydrolysis and solution grafting |
| US10690653B2 (en) * | 2014-12-12 | 2020-06-23 | The Trustees Of The University Of Pennsylvania | Fluid separator for point of care molecular diagnostics |
| US10850239B2 (en) | 2016-06-02 | 2020-12-01 | Amogreentech Co., Ltd. | Filter medium, method for manufacturing same, and filter module comprising same |
| CN106117580A (en) * | 2016-06-23 | 2016-11-16 | 广州新克力生物科技有限公司 | A kind of filter membrane modifying agent for filtrating leukocytes and method of modifying thereof |
| CN106319966B (en) * | 2016-08-18 | 2019-08-16 | 南京双威生物医学科技有限公司 | A kind of processing method of leukocyte filter membranes |
| US20200030503A1 (en) * | 2017-04-20 | 2020-01-30 | Fenwal, Inc. | Systems And Methods For Platelet Filtration Using An Additive |
| TWI715998B (en) | 2019-01-28 | 2021-01-11 | 笙特科技股份有限公司 | Filter material and manufacturing method thereof |
| CN110787647B (en) * | 2019-11-11 | 2024-01-19 | 上海输血技术有限公司 | Platelet leukocyte-removing filter membrane and preparation method thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9756A (en) | 1853-05-31 | Eibeplace and stove | ||
| US4618533A (en) | 1984-11-30 | 1986-10-21 | Millipore Corporation | Porous membrane having hydrophilic surface and process |
| IL88081A0 (en) | 1987-10-20 | 1989-06-30 | Pall Corp | Device and method for depletion of the leucocyte content of blood and blood components |
| DE69005354T4 (en) | 1989-05-09 | 1994-12-01 | Pall Corp | Device and method for reducing the leukocyte content of blood and blood components. |
| US5152905A (en) | 1989-09-12 | 1992-10-06 | Pall Corporation | Method for processing blood for human transfusion |
| US5454946A (en) | 1991-07-22 | 1995-10-03 | Lydall, Inc. | Filter material for filtering leucocytes from blood |
| JPH09508823A (en) * | 1994-01-10 | 1997-09-09 | ヒマシュア，インコーポレイテッド | Devices and processes for the removal of leukocytes and virus inactivating agents from blood. |
| US5660731A (en) * | 1994-11-08 | 1997-08-26 | Pall Corporation | Filter for separating photoactive agent |
| US20010009756A1 (en) * | 1998-01-06 | 2001-07-26 | Derek Hei | Flow devices for the reduction of compounds from biological compositions and methods of use |
| US6337026B1 (en) | 1999-03-08 | 2002-01-08 | Whatman Hemasure, Inc. | Leukocyte reduction filtration media |
-
2003
- 2003-09-23 AT AT03021435T patent/ATE337036T1/en active
- 2003-09-23 ES ES03021435T patent/ES2268245T3/en not_active Expired - Lifetime
- 2003-09-23 EP EP03021435A patent/EP1518573B1/en not_active Expired - Lifetime
- 2003-09-23 DE DE60307849T patent/DE60307849T2/en not_active Expired - Lifetime
-
2004
- 2004-09-22 US US10/573,175 patent/US7524425B2/en not_active Expired - Fee Related
- 2004-09-22 WO PCT/EP2004/010618 patent/WO2005028003A1/en active Application Filing
- 2004-09-22 JP JP2006526611A patent/JP4491460B2/en not_active Expired - Fee Related
- 2004-09-22 CN CNB2004800275672A patent/CN100500232C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4491460B2 (en) | 2010-06-30 |
| ES2268245T3 (en) | 2007-03-16 |
| JP2007505662A (en) | 2007-03-15 |
| CN1856332A (en) | 2006-11-01 |
| ATE337036T1 (en) | 2006-09-15 |
| DE60307849D1 (en) | 2006-10-05 |
| WO2005028003A1 (en) | 2005-03-31 |
| EP1518573A1 (en) | 2005-03-30 |
| US7524425B2 (en) | 2009-04-28 |
| DE60307849T2 (en) | 2007-01-04 |
| EP1518573B1 (en) | 2006-08-23 |
| US20080230475A1 (en) | 2008-09-25 |
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Granted publication date: 20090617 Termination date: 20170922 |