CN100473338C - Combined MR-optical coil for prostate-, cervix- and rectum cancer imaging diagnostics - Google Patents

Combined MR-optical coil for prostate-, cervix- and rectum cancer imaging diagnostics Download PDF

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CN100473338C
CN100473338C CNB2005800038629A CN200580003862A CN100473338C CN 100473338 C CN100473338 C CN 100473338C CN B2005800038629 A CNB2005800038629 A CN B2005800038629A CN 200580003862 A CN200580003862 A CN 200580003862A CN 100473338 C CN100473338 C CN 100473338C
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equipment
magnetic resonance
resonance coil
optics
optical
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CN1913826A (en
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W·杜尔
R·加雷斯
A·亨戈尔
R·韦斯莱德
B·冯鲁克曼
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Siemens AG
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Siemens AG
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Abstract

In exemplay embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical imaging technologies is presented. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging ; (2) image guidance ; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

Description

The combined MR-optical coil that is used for carcinoma of prostate, cervical cancer and rectal cancer image-forming diagnose
The cross reference of related application
The application requires U.S. Provisional Application No.60/541,102 priority, and this provisional application was submitted on February 2nd, 2004, and its full content is hereby incorporated by.
The application is relevant with following U.S. Patent application: submit on January 27th, 2005, name is called the U.S. Patent application No. of " Combined MR-Ultrasound (US) Coil for Prostate-; Ccvix-, and Rectum Cancer Imaging Diagnostics (combination MR-ultrasonic (US) coil that is used for carcinoma of prostate, cervical cancer and rectal cancer image-forming diagnose) " Do not give(interim serial number No.60/541,022), and submit on January 27th, 2005, name is called the U.S. Patent application No. of " Combined Intra-Rectal Optical-MR andIntra-Rectal Optical-US Device for Prostate-; Cevix-, RectumImaging Diagnostics (the combination internal rectum Optical-MR and the internal rectum optics-US device that are used for prostate, cervix uteri, rectum image-forming diagnose) " Do not give Give(interim serial number No.60/541,020), the full content of these two U.S. Patent applications is hereby incorporated by.
Background of invention
1. invention field
The present invention relates generally to the medical imaging field, and relate more particularly to be used for the combining magnetic resonance-optical coil of prostate, cervix uteri and rectum imaging.
2. the explanation of association area
Various diagnosing image methods are used to the diagnosis of carcinoma of prostate, cervical cancer and rectal cancer widely. and the modern diagnosis imaging technique comprises magnetic resonance (" MR "), computer tomography (" CT "), ultrasonic (" US ") and nuclear medicine is (for example, PET (positron emission tomography) (" PET "), single photon emission computed tomography (" SPECT ")).Can provide diagnosis more accurately by making up different imaging techniques.Particularly, can be used to enrich anatomic information (for example, bone and organ) from the anatomy imaging technique from the optical information of optical image technology.
Usually during post processing, make up different imaging techniques.Post processing expends time in usually.In addition, anatomy and optical signature (modality) have only usually and just may accurately make up rigid structure (such as brain).Yet even brain also has little moving, this may cause combination inaccurate potentially.
Summary of the invention
In one aspect of the invention, provide a kind of equipment that is used to provide anatomy and optical diagnostics imaging.This equipment comprises the anatomy image-generating unit that is used for being inserted into body cavity, and wherein this anatomy image-generating unit obtains the anatomical images of this body cavity; And this equipment comprises the optical imagery unit that operationally is connected to this anatomy image-generating unit, and wherein this optical imagery unit obtains the optical information of this body cavity.
In another aspect of this invention, provide a kind of equipment that is used to provide anatomy and optical diagnostics imaging.This equipment comprises the sheath that surrounds magnetic resonance coil.Optical compounds (opticalcompound) is integrated in this coil, so that the detection of near-infrared fluorescent preferably is convenient in the detection of fluorescence.
In another aspect of the present invention, providing a kind of method. this method comprises that the anatomical-optical device with combination is inserted in the body cavity; And from the anatomical-optical device of this combination, receive combination image, wherein this combination image shows based on the information of anatomy imaging with based on the information of optical imagery.
The accompanying drawing summary
Can be by understanding the present invention with reference to the following description of being done in conjunction with the accompanying drawings, wherein identical Ref. No. is represented components identical, and wherein:
Fig. 1 has described the combined MR-optical device according to an exemplary embodiment of the present invention.
Detailed description of the preferred embodiment
Illustrated embodiment of the present invention is described below. for the sake of clarity, whole features of actual implementation are not described in this manual.Certainly should be appreciated that, in the development of any this actual embodiment, must make the specific decision of a lot of implementations in order to realize the specific target of developer, will be such as observing because of the different relevant constraints relevant of system of implementation with affairs. in addition, should be appreciated that, the effort of this development may be complicated and be time-consuming, but it remains normal work to do for those those of ordinary skills that have benefited from present disclosure.
Although the present invention allows various modifications and replacement form, yet but its specific embodiment illustrates and is described in detail at this by the example in the accompanying drawing., should be appreciated that, do not plan the present invention is limited to particular forms disclosed in this description to the specific embodiment, but opposite, intention covers and falls into as by all modifications in the spirit and scope of the present invention that accompanying Claim limited, equivalence and alternative.Should be appreciated that system and method described herein can hardware, the various forms of software, firmware, application specific processor or its combination is realized.
In an exemplary embodiment of the present invention embodiment, propose a kind of with the anatomy imaging technique (for example, MR) with the combined system of optical image technology.This system can be used to various application, and these application include, but are not limited to: diagnosis of (1) cancer and stadium are determined (staging); (2) image guiding; And (3) radiotherapy planning.Image guiding can comprise guided biopsy. for example, prostatectomy has serious adverse potentially, such as sexual impotence and incontinence.Therefore, the last confirmed diagnosis of histology (such as the diagnosis by biopsy provided) can prevent unnecessary prostatectomy. the image guiding can also comprise the guiding minimally-invasive treatment.The present invention can be used to plan radiation therapy, for example, and by detecting, and therefore making health tissues exempt from radiating irradiation to come plan radiation therapy.
A kind of combining magnetic resonance-optics (" MR-Optical ") imaging device is proposed, this imaging device is inserted into the body cavity that easily enters, such as in rectum or the vagina. optic probe is integrated in magnetic resonance (" the MR ") coil, is used to utilize based on optical information and enriches image based on magnetic resonance.
This combined MR-optical device can be inserted in the body cavity and receive combination image, this combination image shows based on the information of anatomy imaging with based on the information of optical imagery. as those of ordinary skills can predict, this combination image can be used to any application in the various practical applications, such as being used for diagnosis (for example, cancer diagnosis), using guiding and treatment planning.
With reference now to Fig. 1,,, the exploded view of the MR-Optical devices 100 of MR imaging with combination and optical imagery function is shown according to an exemplary embodiment of the present invention.Optical-MR device 100 comprises that optic probe 105, MR coil 110, sheath 115 and handheld component 120. optic probes 105 can be the optical pickocffs of per rectum (trans-rectal).Optic probe 105 can be pushed and/or spur with respect to the MR coil.Optic probe 105 also can be independent of 110 rotations of MR coil. and handheld component 120 permission user are easily held and are operated MR-Optical devices 100. optical compounds and can be integrated in this coil.This optics is convenient to the detection of fluorescence, preferably is convenient to the detection of near-infrared fluorescent.Measured fluorescence can be because autofluorescence or the fluorescent probe (fluorescence probe) (contracting agent (contract agent)) that applied cause, this fluorescent probe can be the cancer types special use in the research. this device can be used to detect activable probe (intelligent probe).
Sheath 115 comprises inflexible shell, preferably (transluminescent) of printing opacity also fills with the coupling liquid (not shown). and this coupling liquid preferably has identical optical index with material around, to prevent the bending of (in greater detail following) illuminating bundle.
MR-Optical devices 100 comprise the optical wire 125 that operationally is connected to Optical devices 130.MR-Optical devices 100 further comprise the MR lead 135 that operationally is connected to amplifier 140.The center that this optical wire can be passed MR coil 110 is directed into terminal detector/illuminator lead (optic probe 105).Optical wire 125 can be parallel with MR lead 135.This optical wire is connected with external light source this head with detector 130.Should be appreciated that although do not illustrate for simplicity, as one of ordinary skill in the known, amplifier 140 can be the unitary parts of magnetic resonance tomography (" MRT ").Although be also to be understood that only to show a lead, as those of ordinary skills can predict, optical wire and MR lead can comprise the lead of one or more.MR coil 110 preferably is configured to translucent (for example, the interval between the lead can be made by transparent plastic, and winding wire do not need to be configured to substrate (matrix)/support but to be stable).
In interchangeable embodiment, sheath 115 can utilize the air bag (not shown) of printing opacity to replace.This air bag can comprise the folding investigation head of the liquor pump with the rotation of promoting.Sheath 115 and air bag surround the assembly of MR coil 110.Sheath 115 and air bag can be fixed to body cavity with MR-Optical devices 100. for example, when MR-Optical devices 100 are inserted in the body cavity, make airbag aeration.This air bag preferably utilizes coupling liquid to inflate, and still, in interchangeable embodiment, can utilize air to inflate.If used transparent air bag, then MR coil 110 (for example, RF coil, bird cage) can be a flexible coil, such as by
Figure C200580003862D00071
Company issues on market
Figure C200580003862D00072
In addition, sheath 115 and air bag can be the Any shape (for example, anchor ring) in the different shape that can predict as those of ordinary skills.Sheath 115 and air bag preferably formalize like this, so that MR-Optical devices 110 can pass just checked particular body cavity easily.Although only an air bag is described here, should be appreciated that, as those of ordinary skills can predict, can use more than one (for example, two) air bag.
This optics can cover visual angle or any confined angle of 360 degree.Under the situation of back, may (be independent of MR coil ground) and rotate this lead-in wire from the outside. these two kinds of designs, can both be with respect to this optical lead of MR coil promotion/pulling.This air bag can not cover this optical lead.Illumination and light detect the restriction that can not be subjected to this air bag or this coil.This air bag can be anchor ring or can use two air bags.
Illumination and fluorescent light can be by two isolating lead guiding.Interchangeable modulation technique can be used to distinguish illumination and fluorescent light. and particular design can be worked in CW (continuous wave) pattern.Other design can be used TD (time domain) measurement, OCT (optical tomography) or two photon surveys.Tomography method can be used to increase signal to noise ratio or increase tissue penetration.
For the design of optics, may use three kinds of general embodiments of this optics.
1. light wire (ultimate fibre or fibre bundle) is supplied with circular scattering object (diffuser) or assembled conglobate discrete micro lens. and optical head moves along the MR axle, in the end of light wire revolving mirror is arranged to cover this cavity .2. well, this revolving mirror projects this chamber wall (for example, rectum epithelial cell) circularly with illuminating ray and goes up and catch fluorescent light.This mirror is connected to universal drive shaft and is positioned at the motor of outside, magnetic field. and optical head moves along the MR axle, has DMA (digital-mirror arrays) to cover this cavity .3. well, and this digital-mirror arrays becomes bidimensional or three-dimensional with ray cast.
Can use following light source: wideband light source (for example, xenon lamp or mercury lamp), LED or led array, perhaps laser instrument. detector can be CCD photographing unit or CMOS.If all material of this optics all is insulating. this can not realize that conductive material must be as much as possible little and thin so, to keep the HP coupling minimum.
The internal rectum measurement result that is obtained from MR-Optical devices 100 preferably combines with the external phased array coils (not shown), the zone that is used to increase signal to noise ratio and increases just checked body cavity.External phased array coils is the typical component of standard MRT unit.In one embodiment, external phased array coils can be body arrays (body array), veutro and receiver channel dorsal part are provided. this body arrays has been expanded observable zone in the body cavity, and this zone provides the information of the lymph node that for example is used for determining stadium.
MR-Optical devices 100 can also with combine for the monocrystalline ferrum oxide lactic acid (" MION ") of mr angiography agent.This MION can use the dual sign of fluorescent dye, this fluorescent dye is an optical contrast agents. in addition, MR data set (image that uses the present invention to be obtained from the MRT unit just) can be used to cut apart modeling subsequently that absorbs with NIRF and the autofluorescence that is used to increase NIRF picture quality.
Above disclosed specific implementations only be illustrative, because the present invention can be different but the mode of equivalence revise and implement, these modes are conspicuous for the those of ordinary skills of instruction that have benefited from this. in addition, except described in claim below, the details of the construction or design that goes out shown here is not intended as any restriction.Therefore, obviously can change or revise, and all such variations all be considered to fall in the scope and spirit of the present invention top disclosed specific implementations.Thereby, in this protection of looking for claim below, set forth.

Claims (20)

1. equipment that is used to provide anatomy and optical diagnostics imaging, it comprises:
Be used for being inserted into the magnetic resonance coil of body cavity; And
Operationally be integrated into the optics in the magnetic resonance coil, this optics is used for the donor chamber to be provided illumination light and is used for detecting and catch fluorescence from body cavity in response to the illumination light that is provided.
2. equipment as claimed in claim 1, wherein, described optics detects near-infrared fluorescent.
3. equipment as claimed in claim 1, wherein, described optics moves with respect to described magnetic resonance coil.
4. equipment as claimed in claim 1, wherein, described optics is independent of described magnetic resonance coil rotation.
5. equipment as claimed in claim 1, wherein, the mobile of described optics is reproducible.
6. equipment as claimed in claim 1 further comprises the handheld component that operationally is connected to described magnetic resonance coil.
7. equipment as claimed in claim 1, wherein, described magnetic resonance coil comprises flexible coil.
8. equipment as claimed in claim 1 further comprises the sheath that surrounds described magnetic resonance coil.
9. equipment as claimed in claim 8, wherein, described sheath comprises at least one printing opacity air bag, is used for expanding after being inserted into body cavity, so that described magnetic resonance coil is fixed in the body cavity.
10. equipment as claimed in claim 9, wherein, described printing opacity air bag comprises anchor ring.
11. equipment as claimed in claim 1, wherein, described magnetic resonance coil operationally is connected to the magnetic resonance amplifier.
12. equipment as claimed in claim 1 further comprises first lead and second lead that is used to receive from the data of described optics that are used to receive from the data of described magnetic resonance coil.
13. equipment as claimed in claim 1, wherein, modulation technique is used to distinguish illumination light and fluorescence.
14. equipment as claimed in claim 1, wherein, described optics comprises the light wire that is used for projection illumination light and is used to detect the optical head of fluorescence.
15. equipment as claimed in claim 14, wherein, described light wire comprises at least one fiber, and wherein said at least one fiber is supplied with one of following: circular scattering object and assembled conglobate discrete micro lens.
16. equipment as claimed in claim 14 further comprises the revolving mirror of an end that operationally is connected to described light wire, this revolving mirror is used for illumination light is projected body cavity circularly.
17. equipment as claimed in claim 1, wherein, described optics comprises digital-mirror arrays.
18. equipment as claimed in claim 1 further comprises the light source that illumination light is provided.
19. equipment as claimed in claim 18, wherein, described light source comprises in wideband light source, light emitting diode and the laser instrument.
20. equipment as claimed in claim 1 further comprises the phased array of magnetic resonance coil, the zone that is used to increase signal to noise ratio and increases research.
CNB2005800038629A 2004-02-02 2005-02-02 Combined MR-optical coil for prostate-, cervix- and rectum cancer imaging diagnostics Expired - Fee Related CN100473338C (en)

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BR112015002558A2 (en) * 2012-08-08 2018-05-22 Koninklijke Philips Nv endorectal coil, endorectal surgical apparatus, endorectal coil imaging method and prostate endorectal coil.
EP2911587B1 (en) * 2012-10-26 2018-10-17 Varian Medical Systems, Inc. Nir image guided targeting
US9271673B2 (en) 2012-10-26 2016-03-01 Varian Medical Systems, Inc. NIR image-guided targeting
WO2023082038A1 (en) * 2021-11-09 2023-05-19 深圳先进技术研究院 Magnetic resonance coil

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US4633882A (en) * 1982-03-15 1987-01-06 Olympus Optical Co., Ltd. Device for diagnosing body cavity interiors with ultrasonic waves

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4633882A (en) * 1982-03-15 1987-01-06 Olympus Optical Co., Ltd. Device for diagnosing body cavity interiors with ultrasonic waves

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