CN100439911C - Blood quantity measuring method and apparatus with multi-channel and multi-gain circuit - Google Patents
Blood quantity measuring method and apparatus with multi-channel and multi-gain circuit Download PDFInfo
- Publication number
- CN100439911C CN100439911C CNB031238653A CN03123865A CN100439911C CN 100439911 C CN100439911 C CN 100439911C CN B031238653 A CNB031238653 A CN B031238653A CN 03123865 A CN03123865 A CN 03123865A CN 100439911 C CN100439911 C CN 100439911C
- Authority
- CN
- China
- Prior art keywords
- blood
- value
- electrode
- voltage
- passage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The present invention relates to a method for measuring the blood by multiple channels and multiple gain circuits, which comprises: firstly, a blood sample is collected; secondly, the blood sample is dropped on the electrode part of a biological sensor which provides a voltage value to measure the blood; thirdly, voltage discharge curves measured by different channel circuits are converted to digital signals; fourthly, a voltage value is selected as a measuring value and is output to a microcontrol unit; finally, a digital measuring value of a presetting gain channel is compared with a critical value, a specific gain channel is decided by the microcontrol unit, and the measuring value of the channel is received by the microcontrol unit so as to improve the problem that output voltage curves are distorted and can not be identified because the blood measuring result is controlled by blood glucose concentration.
Description
Technical field
The present invention relates to a kind of blood method for measurement and device with hyperchannel and many gain circuitries, a plurality of channel circuits that particularly a kind of use has different gains carry out the blood measurement, make the blood flow volume measured value select a suitable gain passage, and export the measuring value of this passage via judging.
Background technology
Because the progress of modern medicine science and technology makes human mean lifetime constantly prolong.Yet, because the improvement of living condition makes chronic disease replace various acute infectious diseases, become one of cause of the death main in the civilized society also.In these chronic diseases, especially with diabetes (diabetes) and complication (complication) thereof for.
Diabetes are because the secreted insulin (Insulin) of pancreas in the human body is not enough or act on bad, make sugar part can't be utilized (be about to sugar part and change into heat energy) by human body, and cause sugar part (being blood sugar) concentration in the blood formed a kind of metabolism (metabolism) disease that raises, when blood sugar (blood glucose) concentration of human body surpasses normal value 60～115mg/dl and reaches 180mg/dl, therefore sugar part just can be called diabetes via bladder along with urine is discharged human body.
The cause of disease of diabetes is diversities, may be the infection that is subjected to filterable virus (filtrable virus) by autoimmunity system (auto-immunization), makes that the pancreas beta cell is destroyed, causes the secretion of insulin amount to die-off and falls ill.In addition, also may be because muscle or adipocyte to resistance (insulin resistance) increase of insulin, cause insulin function bad, make that beta cell is withered and pathogenic.Or, and cause blood sugar increasing because in the human body he plants the hormone with anti-insulin and increases.Even be that pancreas is downright bad and cause can't excreting insulin and cause a disease etc.The complication of diabetes then comprises hypoglycemia (hypoglycemia disease), ketoacidosis (Diabetic ketoacidosis; DKA), the non-ketone acid stupor of hypertension hyperosmosis (Nonketotic hyperosmolar syndrome; NKHS) and lacticemia (lacticemia) or the like.
Though much also be difficult to avoid by diabetes or the caused disease of its complication, can reduce or delay the generation of complication via Blood glucose control.Therefore, when more aforesaid symptoms occur, promptly must carry out blood sugar test at once and treat, otherwise, if do not handle in real time, then may be because hypoglycemia, and cause stupor (coma) dead even.In recent years, utilized the various biology sensors (biosensor) of specific ferment catalytic reaction (enzyme catalytic reaction) to be developed, and be used on the medical application.The purposes of this kind biology sensor is to be exclusively used on the treatment of diabetes, with the blood-sugar content that helps diabetic's control itself in scope normally.For the diabetic that is in hospital, the blood-sugar content that it can control itself under doctor's supervision is in normal range.But for the non-diabetic that is in hospital, under the situation that the shortage doctor directly supervises, sufferer itself can then become extremely important by self-control of blood sugar content.Therefore, quick, a simple and easy and blood sugar measuring equipment accurately for the diabetic, just seems suitable important.
The existing blood-glucose meter that can detect blood-sugar content on the market voluntarily for the patient, generally comprise a main test cell and a biochip for measuring blood content, wherein biochip uses a corresponding electrode and cover a responding layer above electrode part, and contain the potassium ferricyanide (potassium ferricyanide) and oxidation ferment (oxidase), for example glucose oxidase ferment (glucose oxidase) on the responding layer.When using blood-glucose meter to measure, earlier biochip is inserted main test cell.Then, the skin that the patient can lancet thorn oneself is to ooze out drop of blood, and the drop of blood that will ooze out directly drops in the biochip that has injected main test cell again.After being inhaled into the responding layer that is positioned at electrode part top when drop of blood, responding layer can be dissolved.After one period schedule time, add that a reference voltage is to biochip, come iron protoxide potassium cyanide (potassium ferrocyanide) with electrochemical reaction (electrochemistry reaction), disengaging electronics, and produce a corresponding kinetic current and pass through electrode.This kinetic current is proportional to the ferrocyanide potassium concn that the ferment catalytic reaction produces or is proportional to concentration of glucose in the blood sample.Because the kinetic current that on biochip, produces, can change and decay gradually in time, so utilize this characteristic, convert the kinetic current of each time point to an output voltage via a current/voltage converter (Current/VoltageConverter), to obtain a voltage-time discharge curve.Then again with a voltage of each time point correspondence through an analog-digital converter (Analog/DigitalConverter; ADC) convert digital signal and deliver in the microprocessor (microprocessor) and handle to, try to achieve the blood glucose concentration value in the blood sample, at last blood glucose concentration value is come out via a liquid crystal display displays, for patient's reference.
In addition, more some biology sensor is in order to obtain the measuring value of blood sugar concentration fast and accurately, and the standard output voltage-time discharge curve mapping table (mapping table) that is built in the output voltage and with corresponding generation in the microprocessor comes mapping.The standard discharge curve that arrives according to institute's mapping decides its corresponding discharge terminal time again.At last, again by microprocessor according to the blood-sugar content in the discharge curve of selected standard and the discharge terminal time decision corpse or other object for laboratory examination and chemical testing thereof.
Because the blood sugar concentration that is contained in each blood corpse or other object for laboratory examination and chemical testing is inequality, when the blood-glucose meter that uses traditional fixed gain (Gain) carried out the blood measurement, its voltage discharge curve that is obtained in the measurement process can change along with the difference of blood sugar concentration.For example, when containing hyperglycaemia concentration in the blood corpse or other object for laboratory examination and chemical testing, the peak value of the sparking voltage that it is measured (peak value) can raise and the whole piece discharge curve also can be along with to rising, therefore after through an amplifying circuit discharge curve being amplified again again, may make the peak value of voltage surpass the frequency range of circuit and produce saturated (saturation) or suffer and cause discharge curve distortion (distortion) by (cut off).Because the voltage of acquisition peak value that can't be definite, so its corresponding discharge terminal time just has error, and the measurement of last gained also must be wrong.In addition, when containing hypoglycemia concentration in the blood corpse or other object for laboratory examination and chemical testing, the peak value of the sparking voltage that it is measured (peak value) can descend and the whole piece discharge curve also can be along with downwards, therefore when the gain of an amplifying circuit is big inadequately, can make discharge curve too concentrated, therefore in the sampling process of carrying out digital conversion, can cause bigger sampling error, also the measurement of therefore last gained also must be wrong.
The measured inaccurate problem of blood sugar concentration of blood-glucose meter that causes fixed gain for the difference that solves blood sugar concentration, some blood-glucose meter uses variable resistor to be used as a switch, after carrying out the blood measurement, judge by the specific people whether measured discharge curve is suitable, and then adjust switch, to obtain a preferable curve, the accuracy that makes blood measure is improved.Because this method needs medical personnel to judge and adjusts, so and be not suitable for general house use person, also need spend the result that could obtain measurement than the time of length simultaneously.Therefore, the blood measuring equipment or the blood-glucose meter that can satisfy real-time (real time), accurate (precise) and convenient (convenient) has urgency.
Summary of the invention
For solving foregoing problems, the present invention proposes a kind of blood measuring equipments that use the formed many gains of multi-channel circuit, and its fundamental purpose causes the output voltage curve to produce distortion or problem that can't identification improving the blood measurement to be subjected to the height of blood sugar concentration.
Another object of the present invention is to utilize a setting value to judge and select a suitable gain circuitry, with the suitable voltage discharge curve of automatic generation one.
A further object of the present invention is to utilize a setting value to judge and select a suitable gain circuitry, and obtains a measurement accurately according to the voltage discharge curve that is obtained.
The present invention also has a purpose, is to utilize a setting value to judge and select a suitable gain circuitry, can be in real time and promptly select a suitable voltage discharge curve and measurement accurately automatically.
According to the above object, the invention provides a kind of blood method for measurement that uses hyperchannel and many gain circuitries, comprising: at first, sample of blood, drawn.Then carry out blood and measure, this blood sample is dripped electrode part in biology sensor, and provide a magnitude of voltage to measure by this biology sensor.Then, the voltage discharge curve that different channel circuits are measured converts digital signal to, selects a digital voltage value as measuring value then, and exports this digital quantity measured value to a micro-control unit.Follow again, relatively the digital quantity measured value and a critical value of a default gain passage, and determine the passage of a certain gain and receive the measuring value of this passage by this micro-control unit.At last, handle the digitizing measuring value of this passage, and carry out the processing of this blood measurement by this micro-control unit.
The invention provides the blood measuring equipment that another kind has hyperchannel and many gain circuitries, comprise: an electrode part, be made up of two electrodes, wherein one first electrode of this electrode part is connected with a biological chip electrically with an end of one second electrode, wherein the other end ground connection of this second electrode; Several channel circuits are made up of several circuit components, and an end of these several channel circuits is connected electrically with the other end of this first electrode; One little processing and control element (PCE), the one end is connected electrically with the other end of these several channel circuits, and the other end then is connected to an output unit.And these several channel circuits more comprise: an amplifying circuit, and the one end is connected electrically with the other end of this first electrode; One A/D conversion circuit, the one end is connected electrically with the other end of this amplifying circuit, and the other end then is connected electrically with this little processing and control element (PCE).
Description of drawings
Fig. 1 is a process flow diagram of the present invention;
Fig. 2 is according to function block schematic diagram of the present invention;
Fig. 3 is schematic layout pattern in a circuit according to the invention.
Symbol description among the figure
10 electrode part
11 first electrodes
12 second electrodes
20 channel circuits
21 amplifying circuits
22 A/D conversion circuits
The road circuit that 201 low gains are logical
The channel circuit of 202 normal gains
The road circuit that 203 high-gains are logical
30 micro-control units
V
OutThe passage output voltage
OP channel operation amplifier circuit
Embodiment
Because the element of some biology sensors (Bio-sensor) that used among the present invention utilizes the principle of specific ferment reaction and the processing of measurement with it, in background technology, describe in detail, so in following explanation, the complete measurement process that does not comprise biology sensor, and only do quoting of emphasis formula, its purpose is in the elaboration of assisting feature of the present invention.And the functional block diagram in the literary composition in following, also not draw according to actual relevant position and complete connection layout, its effect is only being expressed the synoptic diagram relevant with feature of the present invention.In addition, some embodiments of the present invention are all counted example with blood sugar and are illustrated and be described in detail as follows, yet, except describing in detail, the present invention can also be widely implements at other embodiment, and scope of the present invention do not limited, and its scope with claims is as the criterion.
The present invention at first provides a kind of blood method for measurement that uses hyperchannel and many gain circuitries, comprising: at first, and sample of blood, drawn.Then carry out blood and measure, this blood sample is dripped electrode part in biology sensor, and provide a magnitude of voltage to measure by this biology sensor.Then, the voltage discharge curve that different channel circuits are measured converts digital signal to, selects a digital voltage value as measuring value then, and exports this digital quantity measured value to a micro-control unit.Follow again, relatively the digital quantity measured value and a critical value of a default gain passage, and determine the passage of a certain gain and receive the measuring value of this passage by this micro-control unit.At last, handle the digitizing measuring value of this passage, and carry out the processing of this blood measurement by this micro-control unit.
The present invention then provides a kind of blood measuring equipment with hyperchannel and many gain circuitries, comprise: an electrode part, formed by two electrodes, wherein one first electrode of this electrode part is connected with a biological chip electrically with an end of one second electrode, wherein the other end ground connection of this second electrode; Several channel circuits are made up of several circuit components, and an end of these several channel circuits is connected electrically with the other end of this first electrode; One little processing and control element (PCE), the one end is connected electrically with the other end of these several channel circuits, and the other end then is connected to an output unit.And these several channel circuits more comprise: an amplifying circuit, and the one end is connected electrically with the other end of this first electrode; One A/D conversion circuit, the one end is connected electrically with the other end of this amplifying circuit, and the other end then is connected electrically with this little processing and control element (PCE).
Next, will describe concrete method and the device of implementing thereof of the present invention in detail by Fig. 1 to Fig. 3.
Fig. 1 is used for illustrating that the present invention uses the process flow diagram of the blood method for measurement of hyperchannel and many gain circuitries.At first, from step 110, it can ooze out the blood sample of drop of blood as a corpse or other object for laboratory examination and chemical testing so that gather by the skin of patient with pinprick thorn oneself.Then, the drop of blood that will ooze out (also can be described as a corpse or other object for laboratory examination and chemical testing) directly drops in the biochip that injects test cell again, be inhaled into the responding layer that is positioned at electrode part top when drop of blood after, responding layer can be dissolved.After one period schedule time, apply a reference voltage to biochip by biology sensor, measure so that carry out blood, shown in step 120.After reference voltage is added on the biochip, can cause that promptly an electrochemical reaction comes the oxidation reaction layer, for example come iron protoxide potassium cyanide with electrochemical reaction, disengage electronics then, to produce a corresponding kinetic current and by electrode, by different channel circuits kinetic current is amplified and converts to the discharge curve of a voltage then, read the magnitude of voltage of a set point then, for example, read the maximal value of voltage discharge curve.Again with this magnitude of voltage digitizing, to obtain the digitizing measuring value of different channel circuits, shown in step 130.Then, the digitizing measuring value of different channel circuits inputed in the micro-control unit store, this moment, micro-control unit can read the measuring value on one of them passage that preestablishes (default), and this measuring value that reads is compared with a predefined critical value (threshold) again.When preset critical during less than the measuring value on the predefined passage, be expressed as the corpse or other object for laboratory examination and chemical testing of hyperglycaemia concentration, therefore the maximal value of the voltage discharge curve that it measured can be higher, produce the situation of distortion for avoiding this maximum measured value to amplify through voltage amplifier, so the time micro-control unit can be via step 150, read the measuring value of a low-gain channel circuit, then, by step 170 according to this measuring value handle and show blood sugar concentration.For example, the standard output voltage-time discharge curve mapping table that is built in maximum measured value and in the microprocessor is come mapping, with the blood-sugar content in the decision corpse or other object for laboratory examination and chemical testing.When preset critical during greater than the measuring value on the predefined passage, be expressed as the corpse or other object for laboratory examination and chemical testing of hypoglycemia concentration, therefore the maximal value of the voltage discharge curve that it measured can be big inadequately because of the gain of voltage amplifier, and make the voltage discharge curve too concentrated, so when maximal value is taken a sample, can produce the situation of error, so the time micro-control unit can read the measuring value of a high-gain channel circuit via step 160, then, by step 170 according to this measuring value handle and show blood sugar concentration.During measuring value on preset critical levels off to predefined passage, be expressed as the corpse or other object for laboratory examination and chemical testing of euglycemia concentration, therefore the voltage discharge curve that it the measured suitable maximal value of to take a sample, therefore micro-control unit can be via step 140 time, directly this maximal value is transferred to step 170 and is handled and show blood sugar concentration.
Above-mentioned predefined critical value, be the corpse or other object for laboratory examination and chemical testing of different blood sugar concentrations to be carried out a series of measurement with the blood-glucose meter of a fixed gain, and after these measurements are added up and analyze, stipulate out hyperglycaemia concentration range, hypoglycemia concentration range and euglycemia concentration value scope, then with the euglycemia concentration value as this critical value.Therefore, this critical value can be adjusted along with the accumulation of statistical magnitude, and more and more convergence is accurate can to make measurement.Certainly, the yield value that also can design different channel circuits via the statistics and the analysis of measurement.
Fig. 2 is the blood measuring equipment with hyperchannel and many gain circuitries of the present invention, comprise electrode part 10, be made up of two electrodes, wherein first electrode 11 of this electrode part 10 is connected with a biological chip with an end of second electrode 12, wherein the other end ground connection of second electrode 102.Several channel circuits 20, it is made up of several amplifying circuits 21 and several A/D conversion circuits 22, an end of amplifying circuit 21 is connected with the other end of first electrode 11 simultaneously, and an end of A/D conversion circuit 22 is connected with the other end of amplifying circuit 21.The other end of the A/D conversion circuit 22 in the little processing and control element (PCE) 30, one end and several channel circuits is connected, and the other end then is connected to an output unit.
When drop of blood be inhaled into be positioned at electrode part 10 after, blood can be distributed on the responding layer on first electrode 11 and second electrode 12.After biology sensor is added to a reference voltage on the biochip, can cause that promptly electrochemical reaction comes iron protoxide potassium cyanide, disengage electronics then, to produce a corresponding kinetic current (reaction current) and to pass through first electrode 11 and second electrode 12.Then, by the current/voltage-converted circuit in the different channel circuit 20 (Current toVoltage Converter) 21 kinetic current is amplified, and after converting kinetic current to a magnitude of voltage, output to A/D conversion circuit (Analog to Digital Converter; ADC) 22, obtaining a digitized magnitude of voltage, and with the measuring value of this digitized magnitude of voltage as different channel circuits 20.Then, the digitized measurement magnitude of voltage of process that is obtained on the different channel circuits 20 is delivered to a micro-control unit (Micro-processing Control Unit; MCU) in 30, after handling via micro-control unit 30, obtain the voltage measured value of a predefined channel circuit, for example, the passage of selecting euglycemia concentration is as predefined channel circuit.Voltage measured value and a critical value of presetting with this predefined channel circuit compares again.When preset critical during less than the measuring value on the predefined passage, be expressed as the corpse or other object for laboratory examination and chemical testing of hyperglycaemia concentration, therefore the maximal value of the voltage discharge curve that it measured can be higher, therefore select a low-gain channel circuit, and read the measuring value of this passage, and measuring value is handled and is shown blood sugar concentration according to this.When preset critical during greater than the measuring value on the predefined passage, be expressed as the corpse or other object for laboratory examination and chemical testing of hypoglycemia concentration, therefore the maximal value of the voltage discharge curve that it measured can be big inadequately because of the gain of voltage amplifier, and make the voltage discharge curve too concentrated, so select a high-gain channel circuit, so that can be sampled to suitable measuring value, and measuring value is handled and is shown blood sugar concentration according to this.During measuring value on preset critical levels off to predefined passage, be expressed as the corpse or other object for laboratory examination and chemical testing of euglycemia concentration, therefore the voltage discharge curve that it the measured suitable maximal value of to take a sample, therefore directly the standard output voltage-time discharge curve mapping table that is built in this maximal value and in the microprocessor is come mapping, with the blood-sugar content in the decision corpse or other object for laboratory examination and chemical testing.
For specifying the operating process of multi-channel circuit of the present invention, illustrate with side circuit schematic layout pattern shown in Figure 3, for ease of explanation, the channel circuit that only shows three different gains among the figure, wherein passage 201 is the channel circuit of a low gain, passage 203 is the channel circuit of a high-gain, and passage 202 is the channel circuit of a normal gain and is default passage.When drop of blood be inhaled into be positioned at electrode part 10 after, blood can be distributed on the responding layer on first electrode 11 and second electrode 12.Then, biology sensor can provide a reference voltage V
Ref(not being shown among the figure), and after being added to reference voltage on the biochip, make responding layer produce a corresponding kinetic current (reaction current) also by on the responding layer on first electrode 11 and second electrode 12.Then, kinetic current flows through one respectively by operation amplifier circuit 1 (OperationAmplifier; OP1), the formed channel circuit 201,202 and 203 of operation amplifier circuit 2 (OP2) and operation amplifier circuit 3 (OP3), so that convert kinetic current to a magnitude of voltage, obtaining the voltage discharge curve of each channel circuit, and the yield value of each channel circuit (Gain) is defined as
Gain
OP1＝(1+R
2/R
1)
Gain
OP2＝(1+R
4/R
3)
Gain
OP3＝(1+R
6/R
5)
For instance, suppose R
2/ R
1=5, R
4/ R
3=10 and R
6/ R
5=15 o'clock, then channel circuit 201,202 and 203 actual gain were respectively 6,11 and 16.When maximum voltage value that OP1 read is 200mv, be V then at the resulting output voltage values of OP1
Out1=1200mv=1.2V (being 200mv * 6); In like manner, then the another one channel circuit on the formed current/voltage-converted circuit of operation amplifier circuit OP2, the output voltage difference that it read is V
Out2=2200mv, i.e. V
Out2=2.2.Following, is V at the resulting output voltage values of OP3 again
Out3=3200mv, i.e. V
Out3=3.2V.Then channel circuit 201,202 and 203 magnitudes of voltage that obtained are delivered to A/D conversion circuit (ADC) 22 respectively, to obtain a digitized magnitude of voltage.Then, the digitized measurement magnitude of voltage that channel circuit 201,202 and 203 is obtained is delivered in the micro-control unit (MCU) 30 and is handled.At this moment, the first reading pre-set of micro-control unit (MCU) 30 meetings is the magnitude of voltage that the channel circuit of normal gain is imported, and for example, micro-control unit (MCU) 30 sets 202 and be the channel circuit of normal gain, promptly reads the magnitude of voltage of this channel circuit, i.e. V
Out2=2.2V.Then, micro-control unit (MCU) 30 is again with V
Out2Compare with a predefined critical value, wherein this critical value is the voltage measured value of an euglycemia concentration.For example, when critical value was 1.8V, at this moment, preset critical was less than the measuring value V of the channel circuit of normal gain
Out2=2.2V is expressed as the corpse or other object for laboratory examination and chemical testing of hyperglycaemia concentration, so selects the output voltage values of low-gain channel circuit, the i.e. output voltage V of selector channel circuit 201
Out1=1.2V, and measuring value is handled and is shown blood sugar concentration according to this.In like manner,, for example, when critical value is 2.5V, be expressed as the corpse or other object for laboratory examination and chemical testing of hypoglycemia concentration, therefore select the output voltage values of high-gain channel circuit, i.e. the output voltage V of selector channel circuit 203 when preset critical during greater than the measuring value on the predefined passage
Out3=3.2V, and measuring value is handled and is shown blood sugar concentration according to this.During measuring value on critical value levels off to predefined passage, for example, when critical value is 2.1V, be expressed as the corpse or other object for laboratory examination and chemical testing of euglycemia concentration, therefore be about to the output voltage values of the channel circuit 202 of normal gain, promptly read the magnitude of voltage V of this channel circuit
Out2=2.2V directly comes mapping with the standard output voltage-time discharge curve mapping table that is built in this magnitude of voltage and in the microprocessor, with the blood-sugar content in the decision corpse or other object for laboratory examination and chemical testing.
In the explanation of earlier figures 3, and unrestricted the present invention only uses three channel circuits.In the application of reality as shown in Figure 2, optional then several high-gain channel circuits and several low-gain channel circuit make up, wherein several yield values between high and low can design or adjust according to the statistics of experiment, so that can obtain measurement more accurately.In addition, in be built in standard output voltage-time discharge curve mapping table in the microprocessor, can be made into the mapping table of a continuous voltage, also can be divided into several mapping tables that correspond to combination of circuits obtains correct blood glucose concentration value certainly.
Comprehensive above described content, it only is preferred embodiment of the present invention, its all contents that disclosed are not in order to limit protection scope of the present invention; All other do not break away from the equivalence of being finished under the disclosed spirit and changes or modification, all should be included in the scope of claims.
Claims (10)
1. a blood method for measurement that uses hyperchannel and many gain circuitries is characterized in that, comprising:
Sample of blood, drawn;
Execution blood measures, and this blood sample is dripped electrode part in biology sensor, and provides a magnitude of voltage to measure by this biology sensor;
The digitizing measuring value, the voltage discharge curve that different channel circuits are measured converts digital signal to, and selects a digitized voltage value as this digitizing measuring value and export a micro-control unit to;
Relatively the digitizing measuring value and a critical value of a default gain passage, and determine the passage of a certain gain and receive the digitizing measuring value of this passage by this micro-control unit;
Handle the digitizing measuring value of this passage, carry out the processing of this blood measurement by this micro-control unit.
2. the blood method for measurement of use hyperchannel as claimed in claim 1 and many gain circuitries is characterized in that, this digitizing measuring value is the maximum voltage value of this voltage discharge curve.
3. the blood method for measurement of use hyperchannel as claimed in claim 1 and many gain circuitries is characterized in that, this critical value is an adjustable statistical value.
4. the blood method for measurement of use hyperchannel as claimed in claim 1 and many gain circuitries is characterized in that, the digital quantity measured value of this default gain passage and this critical value are to select the passage of a certain gain value in relatively big or small mode.
5. the blood measuring equipment with hyperchannel and many gain circuitries is characterized in that, comprising:
One electrode part is made up of two electrodes, and wherein one first electrode of this electrode part is connected with a biological chip electrically with an end of one second electrode, wherein the other end ground connection of this second electrode;
Several channel circuits are made up of several circuit components, and an end of these several channel circuits is connected electrically with the other end of this first electrode;
One little processing and control element (PCE), the one end is connected electrically with the other end of these several channel circuits, and the other end then is connected to an output unit.
6. a kind of blood measuring equipment with hyperchannel and many gain circuitries as claimed in claim 5 is characterized in that, is coated with a responding layer on this first electrode and this second electrode, and this responding layer is formed by having the material that reacts with blood.
7. a kind of blood measuring equipment with hyperchannel and many gain circuitries as claimed in claim 6 is characterized in that the reaction material that is plated on this first electrode and this second electrode is the potassium ferricyanide or oxidation ferment.
8. a kind of blood measuring equipment as claimed in claim 5 with hyperchannel and many gain circuitries, it is characterized in that, these several channel circuits are made up of the formed passage of several different electronic circuit components, and wherein the electronic circuit component of this each passage more comprises:
One amplifying circuit, the one end is connected electrically with the other end of this first electrode;
One A/D conversion circuit, the one end is connected electrically with the other end of this amplifying circuit, and the other end then is connected electrically with this little processing and control element (PCE).
9. a kind of blood measuring equipment as claimed in claim 8 with hyperchannel and many gain circuitries, it is characterized in that, this little processing and control element (PCE) receives the digital voltage value of this difference channel circuit simultaneously, and wherein a path setting is that a pre-routing and the digital quantity measured value that will preset passage compare processing with a critical value that is pre-set in this little processing and control element (PCE), and export a control signal corresponding.
10. a kind of blood measuring equipment with hyperchannel and many gain circuitries as claimed in claim 9 is characterized in that this critical value is an adjustable statistical value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031238653A CN100439911C (en) | 2003-05-21 | 2003-05-21 | Blood quantity measuring method and apparatus with multi-channel and multi-gain circuit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031238653A CN100439911C (en) | 2003-05-21 | 2003-05-21 | Blood quantity measuring method and apparatus with multi-channel and multi-gain circuit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1548950A CN1548950A (en) | 2004-11-24 |
| CN100439911C true CN100439911C (en) | 2008-12-03 |
Family
ID=34321490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031238653A Expired - Fee Related CN100439911C (en) | 2003-05-21 | 2003-05-21 | Blood quantity measuring method and apparatus with multi-channel and multi-gain circuit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100439911C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105891572A (en) * | 2016-03-31 | 2016-08-24 | 国网山东省电力公司鄄城县供电公司 | Intelligent ammeter used for electric power marketing |
| TWI652480B (en) * | 2017-12-28 | 2019-03-01 | 合世生醫科技股份有限公司 | Method and device for measuring blood analytes |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2228659Y (en) * | 1994-04-05 | 1996-06-05 | 北京怡成生物电子技术有限公司 | Two-pole blood-sugar quick testing stripe |
| US5770028A (en) * | 1994-06-27 | 1998-06-23 | Chiron Diagnostics Corporation | Glucose and lactate sensors |
| US6369618B1 (en) * | 1999-02-12 | 2002-04-09 | Texas Instruments Incorporated | Temperature and process independent exponential voltage-to-current converter circuit |
| CN1350365A (en) * | 2000-12-11 | 2002-05-22 | 武汉大学 | Multichannel digital automatic gain control method and controller |
| JP2002189014A (en) * | 2000-12-20 | 2002-07-05 | Sankyo Co Ltd | Enzyme electrode |
-
2003
- 2003-05-21 CN CNB031238653A patent/CN100439911C/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2228659Y (en) * | 1994-04-05 | 1996-06-05 | 北京怡成生物电子技术有限公司 | Two-pole blood-sugar quick testing stripe |
| US5770028A (en) * | 1994-06-27 | 1998-06-23 | Chiron Diagnostics Corporation | Glucose and lactate sensors |
| US6369618B1 (en) * | 1999-02-12 | 2002-04-09 | Texas Instruments Incorporated | Temperature and process independent exponential voltage-to-current converter circuit |
| CN1350365A (en) * | 2000-12-11 | 2002-05-22 | 武汉大学 | Multichannel digital automatic gain control method and controller |
| JP2002189014A (en) * | 2000-12-20 | 2002-07-05 | Sankyo Co Ltd | Enzyme electrode |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1548950A (en) | 2004-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7347925B2 (en) | Biosensor for monitoring an analyte content with a partial voltage generated therefrom | |
| US7454296B2 (en) | Biosensor with multi-channel A/D conversion and a method thereof | |
| CN102961146B (en) | The method and system of noninvasive Optical blood glucose detection is carried out with spectral data analysis | |
| CN109730695A (en) | Tissue fluid detection device | |
| Ny Hanitra et al. | A flexible front-end for wearable electrochemical sensing | |
| CN113433193A (en) | Noninvasive blood glucose detector and blood glucose detection method thereof | |
| CN100356168C (en) | Method and apparatus for improving blood measurement reliability using multi-channel circuit | |
| CN100439911C (en) | Blood quantity measuring method and apparatus with multi-channel and multi-gain circuit | |
| CN110487872A (en) | A kind of electrochemica biological sensor and its method for sensing based on spatula | |
| CN201859137U (en) | Portable intelligent blood glucose meter | |
| CN204405589U (en) | Physiochemical indice multi-tester | |
| WO2019246043A1 (en) | Methods and systems for low power/low cost hematocrit measurement for blood glucose meter | |
| CN201788165U (en) | Portable intelligent blood glucose meter | |
| CN1296705C (en) | Control circuit for adjustable biological sensor and measuring method thereof | |
| CN104983430B (en) | The blood-sugar detecting instrument of non-intrusion type | |
| TW579429B (en) | Method and apparatus with multi-channel and multi-gain circuits for blood testing | |
| CN218496817U (en) | Noninvasive blood glucose detector | |
| CN104458843A (en) | Intelligent blood glucose tester for medical treatment | |
| TW591231B (en) | Method and apparatus with multi-channel circuits to improve the reliability of blood testing | |
| Fajrin et al. | Development of Diabetes Detection Equipment Using TCS3200 and PH SKU: SEN0161 Sensors | |
| US7510642B2 (en) | Biosensor with improved reading resolution | |
| Thomson et al. | Miniaturized wireless potentiostat for intraoral sensing of glucose and lactate | |
| CN110638467A (en) | Method and system for detecting blood sugar of experimental animal | |
| CN2412248Y (en) | Computerized ketonuria detector | |
| CN109758163B (en) | Noninvasive blood glucose detection system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: YUDONG TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: LIJIE COMPUTER CO., LTD. Effective date: 20060407 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20060407 Address after: Taipei City, Taiwan, China Applicant after: Transpacific IP Pte Ltd. Address before: No. two, No. 1-1, R & D Park, Hsinchu Science Park, Taiwan Applicant before: Lijie Computer Co., Ltd. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: YUXI SCIENCE CO., LTD. Free format text: FORMER OWNER: YUDONG TECHNOLOGY CO., LTD. Effective date: 20090828 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20090828 Address after: Delaware Patentee after: Transpacific IP Pte Ltd. Address before: Taipei City, Taiwan, China Patentee before: Transpacific IP Pte Ltd. |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081203 Termination date: 20110521 |