CN100435881C

CN100435881C - Transdermal element with airbag type switch

Info

Publication number: CN100435881C
Application number: CNB2007100517997A
Authority: CN
Inventors: 王欣宇; 安江峰; 闫玉华; 杨艾玲; 韦明; 焦国豪
Original assignee: Wuhan University of Technology WUT
Current assignee: Wuhan University of Technology WUT
Priority date: 2007-04-05
Filing date: 2007-04-05
Publication date: 2008-11-26
Anticipated expiration: 2027-04-05
Also published as: CN101058000A

Abstract

The invention relates to percutaneous device equipped with air-pocket switch, comprising percutaneous device body (1), capsule air-pocket (2), one-way charge valve (3), discharge valve (4) and helmet (5). The capsule air-pocket is located in the internal cavity of percutaneous device, the upper middle part of percutaneous device is equipped with three holes I, II, and III, pore I and II are connected with capsule air-pocket, pore I is equipped with one-way charge valve (3), pore II is equipped with discharge valve (4), pore III is conduit or wire passage. The helmet matches with pore III. The method for preparing percutaneous device comprises: mixing polymethyl vinylsiloxane, hydrogen-containing silicone oil and hydroxyapatite according to a certain proportion, degassing, injection molding and stewing for 16-24 hours at 80 Deg . C and 1 Mpa. The bioavailability and mechanics performance of percutaneous device are good. When there is no air in the air-pocket, the device is unblocked, and when it is aerated, the air in filled in the percutaneous device, and prevents matter circulation, and acts as a switch.

Description

The preparation method that the transdermal element of airbag type switch is arranged

Technical field:

The present invention relates to a kind of transdermal element, be specially a kind of preparation method that the transdermal element of airbag type switch is arranged.

Background technology:

Transdermal element is the subcutaneous novel intervention medical treatment of inside and outside material, the information transmission and the medical treatment device of diagnosis of carrying out of a kind of long-term implantation, can be used for aspects such as dialysis, body fluid discharge, medicine injection and the observation of body internal information clinically.

Transdermal element adopted tantalum, glass charcoal, polytetrafluoroethylene (PTFE), titanium, hydroxyapatite materials such as (HA), but except that HA, all the other material biocompatibility are all undesirable, cause skin to be grown downwards, and the good HA poor processability of biocompatibility is not easy to shape for complex-shaped transdermal element.

At present, in material or the transmission of Information process, adopt following method mostly in vivo and in vitro:

1, direct puncture method not only brings misery to the patient, and long-term puncture (as hemodialysis etc.) can cause diseases such as the hardening of tissue.

2, simple tremie method, inside and outside material or transmission of Information process rely on conduit with inside and outside connection, in the position of passing skin, conduit directly contacts with skin histology, cause skin histology around the conduit formation groove of growing downwards, diseaseful gathering and breeding, cause inflammation.Simultaneously, adopt this method, the patient must carry some attached apparatuses (such as urinating bag etc.) at any time, gives in patient's daily life and makes troubles, and have potential safety hazard.

3, the tremie method of band transdermal element, this method only limits to experimental stage at present, does not see relevant report clinically.Inside and outside material or transmission of Information process rely on conduit with inside and outside connection, are implanted with a percutaneous element in the position of passing skin, but this element just intercepts contacting of conduit and skin histology, itself does not have the function of switch.

Summary of the invention:

The invention provides a kind of transdermal element of safe, easy belt switch.

Select medical use liquid silicone rubber casting forming for use, and strengthen with HA particle doped and compounded.Can obtain the transdermal element of biocompatibility and good mechanical properties.

The air bag switching device is directly designed on transdermal element, make it when the percutaneous path is provided, also have a switching function.

A kind of transdermal element that is provided with airbag type switch of the present invention, it is characterized in that it comprises the transdermal element body, latex balloon, unidirectional charge valve, air bleeding valve, safety helmet, latex balloon is placed in the transdermal element inner chamber, middle part, transdermal element body outer end is provided with I, II, I hole, III three hole, the II hole links to each other with the latex balloon that is placed in the transdermal element inner chamber, unidirectional charge valve is installed in the I hole, air bleeding valve is installed in the II hole, the III hole is other conduit or lead passage lanes, safety helmet is the stopper in III hole, match with the III hole, the transdermal element tail end combines with the associated conduit sealing of in-vivo embed.

Described I hole, II bore dia are 3 millimeters of Φ, and the III bore dia is 3.3 millimeters of Φ.

Described transdermal element body adopts following method preparation: with A component, B component and hydroxyapatite, by 100: 5: 40 mixings of quality, with homomixture under the vacuum environment degassing 30 minutes after, be poured in the mould, constant temperature left standstill 16-24 hour under 80 ℃, 1 MPa pressure environment, the demoulding, promptly, wherein said A component is poly-ethylene methacrylic radical siloxane, the B component is containing hydrogen silicone oil and platinum catalyst, platinum catalyst is the complex of chloroplatinic acid and isopropyl alcohol, and consumption is 5-10 * 10 of A component and B constituent mass summation ^-6Doubly, described hydroxyapatite particle diameter carried out surface treatment less than 40 microns with the siloxanes coupling agent.

The transdermal element inner chamber settles the good latex balloon of elasticity as gauge tap, and when the air bag unaerated, there is not other barrier that stops the material internal and external exchange in the transdermal element inner chamber, and this moment, element was unimpeded; Behind airbag aeration, air bag is full of the transdermal element inner chamber, and the effect of gauge tap is played in the circulation of blocking-up inside and outside material.

The invention has the beneficial effects as follows, select for use the medical use liquid silastic material not cause scytitis; The element mechanics parameter can recently change by adjusting set of dispense; Element can free switch, time beyond material, the information transmission in vivo and in vitro, and switch closure, pipeline or other apparatus that the transdermal element outer end connects all can be removed.

Description of drawings:

Fig. 1, be provided with the transdermal element structural representation of airbag type switch

Fig. 2, latex balloon sketch map

Fig. 3, transdermal element schematic perspective view

Fig. 4, operation site sketch map

Among the figure: 1 is the transdermal element body, and 2 is latex balloon, and 3 is unidirectional charge valve, and 4 is air bleeding valve, and 5 is safety helmet, and I, II, III are the hole, and I is unidirectional charge valve installing hole, and II is the air bleeding valve installing hole, and III is that conduit or lead insert passage.

The specific embodiment:

The transdermal element structure that is provided with airbag type switch of the present invention as shown in Figure 1.The element monnolithic case is the button shape, it comprises transdermal element body 1, latex balloon 2, unidirectional charge valve 3, air bleeding valve 4, safety helmet 5, latex balloon 2 is placed in transdermal element body 1 inner chamber, middle part, transdermal element body outer end is provided with I, II, III three holes, the latex balloon 2 that settle with the transdermal element inner chamber in I, II hole links to each other, 3 millimeters of bore dia Φ, unidirectional charge valve is installed in the I of hole, air bleeding valve is installed in the II hole, the III hole is that other conduit or lead insert passage, 3.3 millimeters of diameter of phi, whole element tail end combines with the associated conduit sealing of in-vivo embed.

Transdermal element body preparation: select poly-ethylene methacrylic radical siloxane for use, containing hydrogen silicone oil and platinum catalyst, hydroxyapatite are by 100: 5: 40 mixings of quality, with homomixture under the vacuum environment degassing 30 minutes after, be poured in the mould, constant temperature left standstill 16-24 hour under 80 ℃, 1 MPa pressure environment, obtain the transdermal element of biocompatibility and good mechanical properties, wherein the hydroxyapatite particle diameter uses the siloxanes coupling agent to carry out surface treatment less than 40 microns.

The design directly is installed on switch on the transdermal element, make transdermal element as a kind of long-term implant when the percutaneous path is provided, itself also has the function of switch, the patient is not when carrying out the inside and outside material or the information transmission, can remove all devices beyond the skin, alleviate patient's inconvenience of living.

The concrete operation method that the transdermal element that is provided with airbag type switch of the present invention uses:

1, takes off safety helmet, external catheter is inserted transdermal element to the c point;

2, the hole II that outwards winding, air bags, external catheter further is inserted into the d point;

3, inside and outside connection this moment, mass transfer begins;

4, mass transfer finishes, and external catheter is extracted the point to c, traling hole II;

5, usefulness is not passed through hole I Non-return air valve to airbag aeration with the syringe of syringe needle;

6, inflation finishes, and extracts external catheter fully, puts on a safety helmet.

Claims

1, a kind of preparation method that the transdermal element of airbag type switch is arranged, this transdermal element comprises transdermal element body (1), latex balloon (2), unidirectional charge valve (3), air bleeding valve (4), safety helmet (5), latex balloon (2) is placed in the transdermal element inner chamber, there is I at transdermal element body (1) middle part, II, III three holes, the I hole, the latex balloon (2) that settle with the transdermal element inner chamber in the II hole links to each other, unidirectional charge valve (3) is installed in the I hole, air bleeding valve (4) is installed in the II hole, the III hole is the insertion passage of other conduit or lead, safety helmet (5) is the stopper in III hole, matches with the III hole; It is characterized in that, the preparation process of described transdermal element body (1) is: with A component, B component and hydroxyapatite, by 100: 5: 40 mixings of quality, with homomixture under the vacuum environment degassing 30 minutes after, be poured in the mould, constant temperature left standstill 16-24 hour under 80 ℃, 1 MPa pressure environment, the demoulding, promptly, wherein said A component is poly-ethylene methacrylic radical siloxane, the B component is containing hydrogen silicone oil and platinum catalyst, and platinum catalyst is the complex of chloroplatinic acid and isopropyl alcohol, and consumption is 5-10 * 10 of A component and B constituent mass summation ^-6Doubly, described hydroxyapatite particle diameter is less than 40 microns, and the siloxanes coupling agent carries out surface treatment.

2, the preparation method that the transdermal element of airbag type switch is arranged as claimed in claim 1 is characterized in that, described I hole, II bore dia are 3 millimeters of Φ, and the III bore dia is 3.3 millimeters of Φ.