CN100435763C - The whole body heat treatment for tumour of implementing heating inside blood vessel by combining heat seed and blood vessel bracket - Google Patents
The whole body heat treatment for tumour of implementing heating inside blood vessel by combining heat seed and blood vessel bracket Download PDFInfo
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- CN100435763C CN100435763C CNB2005101155443A CN200510115544A CN100435763C CN 100435763 C CN100435763 C CN 100435763C CN B2005101155443 A CNB2005101155443 A CN B2005101155443A CN 200510115544 A CN200510115544 A CN 200510115544A CN 100435763 C CN100435763 C CN 100435763C
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Abstract
A general thermotherapeutic device for treating tumor by heating in blood vessels is composed of the heat generating seed in the form of strip and transplanted in blood vessel for heating blood, a fixer for said heat generating seed, and an external electromagnetic device opposite to said heat seed for generating an alternative electromagnetic field.
Description
Technical field
The present invention relates to the used device of a kind of interventional therapy, particularly a kind of thermotherapeutic apparatus for whole body that in interventional therapy, blood is heated.
Background technology
Tumor high temperature thermotherapy is a kind of by means of heating the naturopathy method that reaches the killing tumor cells tissue.In influencing the factors that tumor thermotherapy obtains high curative effect, the most key heating and the thermometry of surely belonging to.For desirable and satisfied heating, on the physics definition like this: can be exactly 100% cancerous tissue be heated to effective treatment temperature range (41-45 ℃), and keeps certain hour, kill and wound so that cancerous cell is subjected to destructiveness.Meanwhile, must avoid normal structure to be subjected to the hot injury again.So far, research worker has been developed many at the various tumor thermotherapy instruments between the shallow table of human body, tract and tissue, and thermal source mainly adopts microwave, radio frequency, ultrasonic, laser etc.Meanwhile, research worker has been carried out extensive and deep research by means of various means to the basis and the application problem of tumor thermotherapy, and is all obtaining remarkable effect from aspects such as molecular biology, cytobiology, instrument and equipment development and clinical treatments.
Tumor thermotherapy generally can be divided into local heat and whole body heating two big classes.Comparatively popular at present focus ultrasonic thermotherapy, radio-heating treatment etc. are exactly to utilize high temperature that local tumor cell is killed and wounded.Yet, for many malignant tumor, developed into a kind of systemic disease mostly, have very strong transitivity, thereby local thermotherapy is difficult to this class metastatic carcinoma cell is proved effective.Moreover, because the characteristics of biochemical environment in the tissue, the shape of malignant tumor is irregular often, implement localized local thermotherapy device by means of medical image system, general unlikely all cancerous cell are killed totally, do not reach the problem of ideal therapeutic effect, and the cancerous cell remnants of minute quantity all may cause comprehensive recurrence of tumor.This has reduced research worker and the patient confidence to local thermotherapy to a certain extent.At present, this therapy can only be used for routine operation and the invalid patients with terminal of other method, and what play mainly is a kind of effect of appeasing, and to prolong patient's life as far as possible, still can not fundamentally solve the healing problem of tumor.
Yet we can see that really in some cases and actual life of in the past being reported, the case of spontaneous regression of tumor occurs after much having passed through a hyperpyrexia, and this has just caused concern and the research of people to whole-body hyperthermia.Whole-body hyperthermia since at be the heating of whole human body, can overcome the shortcoming of local thermotherapy in theory.
The whole-body hyperthermia method that is developed so far comprises method biology, through body surface heating method, extracorporeal circulation heating means etc.Biology method by in patient's body, inject toxin, antibacterial is brought out the body heat production.Inconsistent because of body to this type of substance reaction, can not assess in advance the caloric value that produces, safety is not high, thereby this type of whole-body hyperthermia method the earliest is not used in modern thermotherapy at present.The body surface rule of heating mainly contains warm blanket pack, hot wax bath method, hot water instructions about how to take medicine, radiation hot type heating method.Wherein warm blanket pack, hot wax bath, hot water instructions about how to take medicine medical expense height, side effect big (mortality rate is up to 5%-12%) has limited their application in whole-body hyperthermia.Radiation hot type heating method adopts heat ray (as infrared ray), irradiation subcutaneous tissue and blood capillary, the temperature of raising tissue and blood.This kind method belongs to the non-intruding treatment, and medical expense is lower.Shortcoming is that the heating-up time is long, can cause part patient local skin scald.
The method of extracorporeal circulation heating is a kind of heating method from inside to outside, attempts to overcome the body surface heating method and can not realize the deep tissue heating, and the unequal problem of heating-up temperature.Specific practice is with outside the blood circulation lead body, by heat exchanger blood is heated up, and carries in the ex vivo again.Before heating, the surgeon need use artificial blood vessel to do a blood shunt loop between femoral artery and femoral vein.Its advantage is that temperature-rise period is shorter relatively, about 60min.Shortcoming is to belong to a kind of invasive treatment, needs the whole body anticoagulant.Wound to patient is big, infects the treatment procedure complexity easily.Medical expense is than the infrared ray height of heating, and therapeutic process is had relatively high expectations to the functional level of patient's heart and kidney and other organs.During the Joint Implementation chemotherapy, unsettled patient has more danger to renal function.
Summary of the invention
For solving the problem that prior art exists, the invention provides tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating, it has solved local thermotherapy's device of prior art, does not reach the problem of ideal therapeutic effect.The objective of the invention is:, be implanted into single pair or overpay intravascular stent at the shallow thick blood vessel of people's body surface, and ferromagnetic hot seed is fixed between the support by means of the blood vessel interventional technique.So when applying high frequency electric field, ferromagnetic hot seed can produce eddy current and then heating under electromagnetic field effect, heat the blood of human body of flowing through herein thus, the circulation by means of blood reaches the purpose that improves body local and even whole body temperature quickly and effectively then.Ferromagnetic hot seed has automatic attemperation function, need not complicated temperature control and temperature measuring equipment.Hot seed can heat after implanting as required at any time, and operational approach is succinctly convenient.
Tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating of the present invention, comprise: be implanted in intravascular in hot seed 3 of the pyrotoxin that blood is heated up and the fixture 5 that is used for fixing the hot seed 3 of pyrotoxin, be positioned at the electromagnetic field equipment 2 that adds external and the generation alternating electromagnetic field, the hot seed of pyrotoxin 3 with add electromagnetic field equipment 2 and be oppositely arranged, the hot seed 3 of pyrotoxin is a strip.
Further, tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating of the present invention, can also have following characteristics: described fixture 5 is made up of intravascular stent 1 and fixed traction silk 4, the hot seed 3 of pyrotoxin is between two intravascular stents 1, and two ends of the hot seed 3 of pyrotoxin are connected with intravascular stent 1 by fixed traction silk 4 respectively.
Described intravascular stent 1 is netted nick-eltitanium alloy stent or sacculus cribbing (the sacculus cribbing is a blood vessel minimally invasive surgery structure commonly used, directly adopting by reference).
The material of the hot seed 3 of described pyrotoxin is that monel maybe can produce big heat and have the material of fine biocompatibility.
The material of the hot seed 3 of described pyrotoxin is: γ-Fe
2O
3, Fe
3O
4, Ni, Co, Fe, FeCo, NiFe alloy or MeFe
2O
3, Me=Co, Mn or Ni.
The cross sectional shape of the hot seed 3 of described pyrotoxin is circle, rectangle or triangle etc.
The hot seed of described pyrotoxin 3 is twisted into for one or two strands at least.
The diameter of the hot seed 3 of per share pyrotoxin at 10nm between the 1mm.
The coating with biocompatibility can be adopted in the hot seed of fixed traction silk 4 and pyrotoxin 3 surfaces, as: golden film.
Hot seed 3 of described pyrotoxin and fixture 5 outsides are set with conduit 6.
The present invention is with the hot seed 3 of pyrotoxin, fixture 5 and conduit 6 implant as treatment usefulness.Behind the percutaneous puncture, the clinician can send the conduit that intravascular stent, fixed traction silk, the hot seed of pyrotoxin are housed into the thick blood vessel of human body, as femoral artery under CT or ultransonic guiding.At this moment, conduit is retreated, first self-expanding formula intravascular stent (this expansion type intravascular stent mainly adopts marmem to make, and is prior art products, can directly purchase from market) that then is positioned at catheter proximal end begins to expand voluntarily under the blood heat effect.Conduit continues to withdraw from, traction fiber and hot seed intravasation chamber.Second intravascular stent expands voluntarily then, and the intravasation intracavity is fixed.Treat conduit withdraw from fully external after, wound is sewed up.
In the actual implementation process, can in place's blood vessel, implant a plurality of intravascular stents simultaneously, fixing many hot seeds according to adding the heat needs; Also can be implanted into many supports and hot seed, add heat with further increase at the many places blood vessel.
The invention has the advantages that and traumatic very little to patient have invasive.Can adjust as required and add heat.In case after hot seed implantation, patients'blood is heated and can be carried out at general out patient service, it is quite convenient based on carrying out of general tumour thermotherapy of the present invention that this makes.In addition, the price of this device is low, and operation process is simple, compares with traditional like product, has very strong striving property unexpectedly.
Crucial part of the present invention has been to introduce first the blood heating method of endovascular stent in conjunction with hot seed; Though proposed to adopt the method for the existing tumor thermotherapy of hot seed in the past, but because of hot seed places tissue, around its caloric value can only reach by heat conduction, owing to organize thermal conductivity lower, the effect of this heat transfer is not good, induce living heat and directly blood is carried out the outside in the present technique, make the general tumour thermotherapy become possibility.
Obviously, blood heating method provided by the invention is not limited to the above scheme that provides, also can derive more blood vessel heating techniques thus, can adopt other heater elements to replace such as hot seed aspect, we can be fixed on elongated laser fiber, radio-frequency antenna etc. in the blood vessel by net dress support, and its lead then is drawn out to the outside, in case need heat blood the time, energized can realize being similar to the blood heating function of hot seed.
Description of drawings
Fig. 1 is a structural representation of the present invention.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment.
Fig. 1 is the tumor thermotherapeutic apparatus for whole body that hot seed of employing provided by the invention and intravascular stent are realized the blood vessel internal heating, also is one embodiment of the present of invention.Comprise: in order to two intravascular stents 1 of fixing ferromagnetic hot seed; Produce the electromagnetic field equipment 2 that adds of alternating electromagnetic field; Be used to make the ferromagnetic hot seed 3 of pyrotoxin of blood intensification; Fixed traction silk 4.
Wherein, intravascular stent can have 2 to 100.Support can adopt in the blood vessel endogenous cause of ill and be heated and the self-inflated nick-eltitanium alloy stent of automatic expansion, also can adopt the sacculus cribbing by means of the external force expansion, and the diameter of single carrier unit band can be at 10nm between the 1mm.The material of hot seed 3 can adopt monel or other can produce big heat and have the material such as the γ-Fe of fine biocompatibility
2O
3, MeFe
2O
3(Me=Co, Mn, Ni etc.), Fe
3O
4, Ni, Co, Fe, FeCo or NiFe alloy etc.Hot seed 3 cross sectional shapes can be circle, triangle or rectangle, can be twisted into by one or more strands of, the diameter of per share hot seed at 10nm between the 1mm.Fixed traction silk 4 can have the 1-100 root, and material can adopt NiTi or monel silk, the diameter of every rhizoid at 10nm between the 1mm.In addition, but independent stationary between the intravascular stent of a place or many places trunk and the hot seed in the implant into body also can interconnect.Add electromagnetic field equipment 5 and adopt conventional calutron to get final product, can directly purchase from market or customized, its electromagnetic field frequency can be at 85Hz-95Hz, also can be at frequency range such as 5Hz-2000MHz widely.The coating with biocompatibility can be adopted in hot seed 3 and anchoring filament 4 surfaces, as golden film.
For quickening the rapid rising of human body whole body body temperature, apparatus of the present invention also comprise the parcel woollen blanket that is used to strengthen the whole-body hyperthermia effect, and the infrared radiometer of ligand external exposure intensification etc., therefore, thermotherapeutic apparatus for whole body provided by the invention can be implemented inside and outside heating simultaneously, thereby the programming rate of human body is better than single in the past mode of heating, can shorten treatment time greatly thus and alleviate patient's misery.In heating process, too high temperature is easy to cranial nerve is caused damage, thereby this device also comprises and is used to protect human body significant points such as brain etc. to avoid adding hot injury's head cooling water bag, frozen water bag or semiconductor cooler etc.
Thermotherapy process of the present invention is as follows:
1. blood vessel is got involved and is prepared before the doctor does conventional art, does sterilization of instruments, and seal wire, conduit, intravascular stent, guide wire are prepared.The operation region of interest is done local anesthesia.
2. behind the percutaneous puncture, under the supervision of image documentation equipment, insert guide wire.After guide wire is in place, insert conduit and interior single or multiple supports thereof.According to the operation plan that designs in advance, at the slow rollback conduit of assigned address.Under warm blood heat effect, first self-expandable stent opens automatically, thereby is fixed in the blood vessel.Make anchoring filament, hot seed intravasation chamber successively, second support intravasation chamber, and expand voluntarily.As in place all right, then can withdraw from seal wire, conduit, do wound and sew up.Finish intervene operation.
3. after treating patient's wound healing, can carry out thermotherapy.The position of implanting hot seed is placed in the alternating electromagnetic field, and under the action of a magnetic field, hot seed begins heating, and blood heats up.In the process of heating, patient's body temperature is monitored, nursing is carried out in inquiry patient impression.
4. for accelerating programming rate, this blood vessel internal heating process is the outer heating process of ligand simultaneously also, realizes as adopting the body surface microwave irradiation.And carry out patient's heat insulation work, adopt measures such as woollen blanket parcel.
5. for preventing that some key positions of human body are subjected to the hot injury,, when heating, also take local cooling's measure, brain is cooled off as adopting ice cap or cooling water as brain.
In a word, thermotherapeutic apparatus for whole body provided by the invention is a kind of tumor naturopathy method that can directly heat blood vessel of invasive, and it can spread all over whole body rapidly with heat by flowing of warm blood, and pivotal role is brought into play in the expectation meeting in clinical practice.
The present invention is based on the basis that various whole-body hyperthermia system pluses and minuses are compared, a kind of new systemic blood cyclic heating method based on the blood vessel interventional technique that provides.In the present invention, we adopt prepositioned fine ferromagnet instant heating seed in blood vessel, induce heat production by the applying high frequency electricity field action, thereby this place's blood is carried out direct heating, and flowing by means of it reaches whole body with heat again.As everyone knows, the blood vessel interventional technique is a kind of under X line, ultrasonic, MRI guiding, based on the endovascular method of conduit.The present invention utilizes the blood vessel interventional technique, can be easily in Wicresoft's mode with single or many trunks in the many hot seed implant into body.In case when the outside applies electromagnetic field, can induce small hot seed in this place's blood, to produce heat, and then improve the purpose that blood heat reaches whole-body hyperthermia.This kind blood temperature-rising method has overcome the shortcoming that conventional bulk outer circulation method exists to a certain extent.So far, similar general tumour thermotherapy method of the present invention does not all have report in patent documentation and the scientific paper at home and abroad, and more valuable is that this equipment has easy and simple to handle, once implants, and can repeatedly repeat heating, the characteristics little to patient's invasive.
Claims (10)
1. realize the tumor thermotherapeutic apparatus for whole body of blood vessel internal heating in conjunction with hot seed and intravascular stent, it is characterized in that, comprise: be implanted in intravascular in the hot seed of pyrotoxin (3) that blood is heated up be used for fixing the fixture (5) of the hot seed of pyrotoxin (3), be positioned at the electromagnetic field equipment that adds (2) external and the generation alternating electromagnetic field, the hot seed of pyrotoxin (3) with add electromagnetic field equipment (2) and be oppositely arranged, the hot seed of pyrotoxin (3) is a strip.
2. the tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating as claimed in claim 1, it is characterized in that, described fixture (5) is made up of intravascular stent (1) and fixed traction silk (4), the hot seed of pyrotoxin (3) is positioned between two intravascular stents (1), and two ends of the hot seed of pyrotoxin (3) are connected with intravascular stent (1) by fixed traction silk (4) respectively.
3. the tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating as claimed in claim 2 is characterized in that described intravascular stent (1) is netted nick-eltitanium alloy stent or sacculus cribbing.
4. the tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating as claimed in claim 1, it is characterized in that the material of the hot seed of described pyrotoxin (3) is monel or other material that can produce big heat and have fine biocompatibility.
5. as claim 1 or 4 described tumor thermotherapeutic apparatus for whole body, it is characterized in that the material of the hot seed of described pyrotoxin (3) is: γ-Fe in conjunction with hot seed and intravascular stent realization blood vessel internal heating
2O
3, Fe
3O
4, Ni, Co, Fe, FeCo, NiFe alloy or MeFe
2O
3, Me is Co, Mn or Ni.
6. the tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating as claimed in claim 1 is characterized in that the cross sectional shape of the hot seed of described pyrotoxin (3) is circle, rectangle or triangle.
7. describedly realize it is characterized in that the tumor thermotherapeutic apparatus for whole body of blood vessel internal heating that the hot seed of described pyrotoxin (3) is twisted into for one or two strands at least in conjunction with hot seed and intravascular stent as claim 1 or 6.
8. as claimed in claim 7ly realize it is characterized in that the tumor thermotherapeutic apparatus for whole body of blood vessel internal heating in conjunction with hot seed and intravascular stent, the diameter of the hot seed of per share pyrotoxin (3) at 10nm between the 1mm.
9. the tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating as claimed in claim 1 is characterized in that adopt on fixed traction silk (4) and the hot seed of pyrotoxin (3) surface has the coating of biocompatibility.
10. the tumor thermotherapeutic apparatus for whole body in conjunction with hot seed and intravascular stent realization blood vessel internal heating as claimed in claim 9 is characterized in that described coating is golden film.
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| CNB2005101155443A CN100435763C (en) | 2005-11-04 | 2005-11-04 | The whole body heat treatment for tumour of implementing heating inside blood vessel by combining heat seed and blood vessel bracket |
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| CNB2005101155443A CN100435763C (en) | 2005-11-04 | 2005-11-04 | The whole body heat treatment for tumour of implementing heating inside blood vessel by combining heat seed and blood vessel bracket |
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| CN100435763C true CN100435763C (en) | 2008-11-26 |
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| CN102781378B (en) * | 2009-03-30 | 2015-08-19 | 史蒂夫·安德烈·博丹 | In hyperthermia process or optionally cool the extracorporeal blood treat-ment apparatus of brain, system and method in the process of induction brain low temperature relative to health |
| WO2012130337A1 (en) * | 2011-04-01 | 2012-10-04 | Flux Medical N.V. | System, device and method for ablation of a vessel's wall from the inside |
| AU2012375973B2 (en) * | 2012-04-02 | 2017-11-23 | Medical Development Technologies S.A. | Implant device and system for ablation of a renal arterial wall from the inside |
| CN105030393B (en) * | 2015-07-24 | 2017-06-06 | 汇澜生物工程（浙江）有限公司 | Nano-gold film memorial alloy Esophageal Stent and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4303636A (en) * | 1974-08-20 | 1981-12-01 | Gordon Robert T | Cancer treatment |
| CN1371753A (en) * | 2001-02-24 | 2002-10-02 | Mfh控制体温系统有限公司 | Magnetic coil of magnetic field generator for heating magnetic material in biological organism |
| US6497647B1 (en) * | 2001-07-18 | 2002-12-24 | Ati Medical, Inc. | Radiation and thermal energy source |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4303636A (en) * | 1974-08-20 | 1981-12-01 | Gordon Robert T | Cancer treatment |
| CN1371753A (en) * | 2001-02-24 | 2002-10-02 | Mfh控制体温系统有限公司 | Magnetic coil of magnetic field generator for heating magnetic material in biological organism |
| US6497647B1 (en) * | 2001-07-18 | 2002-12-24 | Ati Medical, Inc. | Radiation and thermal energy source |
Non-Patent Citations (1)
| Title |
|---|
| 基于肿瘤靶向热疗的磁性微/纳米颗粒研究进展. 吕永钢，刘静.微纳电子技术，第9期. 2004 * |
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