CN100427025C - Method for judging concentration of lood sugar - Google Patents
Method for judging concentration of lood sugar Download PDFInfo
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- CN100427025C CN100427025C CNB031102980A CN03110298A CN100427025C CN 100427025 C CN100427025 C CN 100427025C CN B031102980 A CNB031102980 A CN B031102980A CN 03110298 A CN03110298 A CN 03110298A CN 100427025 C CN100427025 C CN 100427025C
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Abstract
The present invention relates to a method for obtaining the corresponding blood-sugar concentration by using a crest value of an ascent curve. All obtained peak-dot values which are measured after predetermined sampling time are averaged so that an average peak-dot value can be obtained, and subsequently, an actual blood-sugar concentration value can be obtained and calculated by the average peak-dot value, a resistance valve of a measured circuit, a reference resistance value and the reference voltage; in addition, the maximum crest value with different kinds of height through different kinds of predetermined sampling time, a mapping table can be manufactured through the maximum crest value and the output voltage value, and blood-sugar concentration values with different output voltage values can be obtained by the mapping table.
Description
Technical field
The present invention relates to a kind of method of judging blood sugar concentration, more particularly a kind of crest value of ascending curve that utilizes is judged blood sugar concentration.
Background technology
In the past, there has been the system of many monitoring blood glucose characteristics to be established.As have the device that to judge the blood glucose characteristic, these blood glucose characteristics such as blood Oxidation (bloodoxygenation), blood sugar concentration (blood glucose concentration) or the like.Yet, when attempt will utilize non-intrusion type (noninvasive) blood glucose monitoring system correctly to measure blood sugar concentration, the concentration of this blood glucose is difficult to concrete mode and represents, wherein non-intrusion type blood glucose monitoring system such as spectrophotometric spectra gauge (spectroscopic).
In addition, the degree of difficulty of the blood sugar concentration of accuracy of judgement has several situations.The first, in mobile blood, find the blood glucose (its lower concentration values is less than about 100 to 1000 grades of haemachrome) of low concentration, make under the situation of low concentration, to be difficult to detect Noninvasive and signal to noise ratio (signal to noise ratio) that simultaneously need be high.In addition, in the spectrophotometric spectra measuring method, the characteristic of glucose (glucose) is similar in appearance to the characteristic of the moisture content with high concentration in blood.Therefore, when using optical monitoring system, because glucose is in blood, so the optical characteristics of moisture content can make the characteristic of optical signalling by fuzzy.
In addition, the anhydrous phase reagent test piece (dry phase reagent test strip) with composition of enzyme has been applied in the clinical experiment in (clinical laboratory), hospital and the family widely to measure reliable blood sugar concentration.These test pieces can be measured glucose, cholesterol (cholesterol), protein (proteins), ketone (ketones), phenyl propyl acid (phenylalaine) or the glucose in blood, urine (urine) or saliva.Being used for measure glucose concentration in the sample of blood often is used.In fact, for many sufferers, must use every day the reagent test piece to come measuring blood concentration with diabetes.
Test piece is well known and comprises test agent make that under different haemoconcentrations, its test piece has different change color in test piece.By test piece being inserted measuring blood concentration in a meter such as the reflective photometer (reflectance photometer), utilize this reflective photometer can judge the change color that blood glucose is produced after reacting with test agent in test piece and judge its blood glucose concentration value.Wherein, test agent generally comprises for example glucoseoxidase (glucose oxdiase) of enzyme (enzyme), becomes gluconolactone (gluconic acidlactones) and hydrogen peroxide (hydrogen peroxide) in order to oxidizing glucose; Oxidable dyestuff (oxidizable dye) and material with peroxidating active matter (peroxidative activity), wherein the peroxidating active substance is in the presence of hydrogen peroxide, can be optionally under the Oxidation of oxidable dyestuff and by catalysis.
Summary of the invention
Main purpose of the present invention is according to ascending curve and blood sugar concentration dependency to be arranged, slope by known peak dot, resistance, with reference to resistance and reference voltage, can and calculate its meansigma methods by each measured after default sample time peak dot, obtain blood glucose concentration value by this mean value calculation.
A further object of the present invention is to utilize a subdifferential of peak value greater than zero characteristic, at the default maximum that obtains peak value sample time.
A more purpose of the present invention be by different sample times to obtain the maximum crest value of differing heights, utilize these crest values to be made into comparison list (mapping table).
A time purpose of the present invention is to utilize the synopsis can be in the hope of the blood glucose concentration value of different output voltage values.
For reaching above-mentioned purpose, the invention provides a kind of method of measuring blood concentration, it is characterized in that the method for this measuring blood concentration comprises:
Import the simulation source relevant with blood sugar concentration to having in the amplifier circuit, wherein this amplifier circuit comprises a resistance, a reference resistance and a reference voltage;
Change this simulation source and become a digital signal by an analog signal conversion;
Handle this digital signal;
Export this digital signal with an ascending curve form, obtain maximum crest value according to the ascending curve of this digital signal; And
Try to achieve a blood glucose concentration value of this blood glucose solution in conjunction with a reference voltage level of a resistance value of a resistance value of this resistance, this reference resistance, this reference voltage and an output voltage values and this maximum crest value.
According to the above object, the invention provides a kind of crest value of ascending curve that utilizes and try to achieve corresponding blood sugar concentration.The present invention according to the peak dot of ascending curve as the foundation of judging.The peak dot of resistance, reference resistance and reference voltage by known slopes, measuring circuit is also measured resulting each peak dot value and is averaged after default sample time, to obtain a meansigma methods, calculate actual blood glucose concentration value by the meansigma methods of this peak dot and resistance, reference resistance and the reference voltage of measuring circuit.In addition, can by different default sample times to obtain the maximum crest value of differing heights, be made into comparison list (mapping table) by these maximum crest values, utilize the blood glucose concentration value of synopsis can be in the hope of different output voltage values the time.
Description of drawings
Fig. 1 is disclosed technology according to the present invention, and expression utilizes crest value to judge the block chart of blood sugar concentration;
Fig. 2 is disclosed technology according to the present invention, the ascending curve of expression blood sugar concentration and the graph of a relation of operation amplifier circuit;
Fig. 3 is disclosed technology according to the present invention, utilizes crest value to try to achieve the flow chart of blood sugar concentration;
Fig. 4 is disclosed technology according to the present invention, has the ascending curve figure of a blood sugar concentration;
Fig. 5 is disclosed technology according to the present invention, the ascending curve figure that the blood glucose solution of variable concentrations is produced.
Main symbol description among the figure
10 simulation sources
12 blood processor
The 12A operation amplifier circuit
The 12B AFE (analog front end)
The 12C MCU Microprocessor Control Unit
14 display devices
20 blood glucose solution are via the simulation source that is produced after the catalyst reaction in the test piece
22 treatment of simulated source is to produce a crest figure
24 obtain the maximum of peak dot under different default sample times
26A calculates its meansigma methods for resulting each peak dot value after Preset Time, and obtains a mean wave peak value
26B can obtain the concentration value of a blood glucose solution according to this mean wave peak value
The a plurality of maximum crest value that 28A obtains is made comparison list
28B utilizes the output voltage values of the unknown blood sugar concentration that synopsis can obtain importing, then can be in the hope of the blood glucose concentration value of reality by this output voltage
The specific embodiment
Some embodiments of the present invention can be described in detail as follows.Yet except describing in detail, the present invention can also be widely implements at other embodiment, and scope of the present invention do not limited, and its scope with claims is as the criterion.
By blood glucose (blood glucose) solution being placed on test piece (test strip) top, owing to have test agent (test reagent) or catalyst (catalyst) in the test piece, as enzyme (enzyme), this test agent can with blood glucose solution generation redox reaction (oxidation reductionreaction), and produce a simulation source (analog source).Then this simulation source is inputed in the circuit of a meter, analogue signal is delivered to a blood processor, in order to analog signal conversion is become digital signal, and export display device to through circuit thus.
Judge the block chart of blood sugar concentration with reference to figure 1 for utilize crest value according to the present invention.Among the figure, reference number 10 expression blood glucose solution carry out chemical reaction with the test piece with catalyst such as enzyme and the simulation source that produces; Then this simulation source is inputed to a blood processor 12, handle device 12 by this and will simulate the source conversion and export display device to.Wherein, blood processor comprises an operation amplifier circuit (OP; Operational amplifier) 12A has one group of resistance at least in this operation amplifier circuit 12A, wherein blood sugar concentration heals when high, and its resistance is higher.Then, this simulation source is sent to AFE (analog front end) (AFE; Analog front end) 12B when the simulation source is sent to AFE (analog front end), then becomes analog signal conversion digital signal (digitalsignal), and wherein, analog front-end device 12B can be analog digital conversion system (ADC; Analogto digital converting system).Then, digital signal is sent to MCU Microprocessor Control Unit (MCU; Microprocessor control unit), after handling, export digital signal to display device 14.Then treated digital signal is come out as screen display via display device 14, wherein shown figure is a curvilinear figure.
With reference to figure 2, the ascending curve of expression blood sugar concentration and the graph of a relation between the operation amplifier circuit.After the reaction of blood glucose solution and test agent became the analogue signal of input operational amplifier circuit, the height of its curve decided with resistance according to blood glucose is dense, and blood sugar concentration heals, and then resistance is higher for height.When blood glucose solution inputs to operation amplifier circuit, by the resistance R in the known slope of curve, the operation amplifier circuit
G, reference resistance R
fAnd reference voltage V
RefThe simulation source can be converted to form output, i.e. output voltage (V with voltage
Out).
With reference to figure 3, try to achieve the flow chart of blood sugar concentration for utilize crest value according to the present invention.In the drawings, step 20 expression blood glucose solution is via the simulation source (analog source) that is produced after the catalyst generation chemical reaction in the test piece, and wherein this chemical reaction can be redox reaction (oxidation reduction reaction).Then, in step 22 a crest figure is handled and is produced in this simulation source.In step 24, under different default sample times, obtain the maximum (maximum value) of peak dot then.In one of first preferred embodiment of the present invention, be after Preset Time, to calculate its meansigma methods, and obtain a mean wave peak value for resulting each peak dot value at step 26A.Then, utilize this mean wave peak value can obtain the concentration value of a blood glucose solution at step 26B.In addition, in another preferred embodiment of the present invention, step 28A makes comparison list (mapping table) with a plurality of maximum crest value that obtains, and wherein synopsis is the graph of a relation of expression blood sugar concentration and output voltage (voltage).Then, step 28B is the output voltage values that utilizes the unknown blood sugar concentration that this synopsis can obtain importing, then can be in the hope of the blood glucose concentration value of reality by this output voltage.
With reference to figure 4, the ascending curve figure that expression has a blood sugar concentration.Utilize curve one subdifferential greater than zero characteristic, y (t
1)-y (t
0)＞0, promptly the difference of the very first time and zero-time promptly can obtain the maximum at the peak dot of Preset Time greater than zero.In addition with reference to figure 4, in preferred embodiment of the present invention, maximum according to this peak dot, and therefore a plurality of peak dot value addition after getting default sample time and average and obtain an average peak point value can try to achieve this average peak point value and known peak dot slope (slope), resistance, reference resistance value and reference voltage the blood glucose concentration value of reality.
With reference to figure 5, the ascending curve figure that the blood glucose solution of expression variable concentrations is produced.In Fig. 5, C1, C2 and C3 represent the resulting result of different test piece measuring blood concentration respectively.Similarly, also be according to curve one subdifferential greater than zero characteristic, try to achieve the maximum of each curve, making the contrast figure (mapping table) of an output voltage and blood sugar concentration according to the maximum of these plural groups then.Therefore, know when wishing to get-during unknown blood sugar concentration, can be by its output voltage values and according to the blood glucose concentration value of synopsis in the hope of reality.
The above is preferred embodiment of the present invention only, is not in order to limit protection scope of the present invention; All other do not break away from the equivalence of being finished under the disclosed spirit and changes or modification, all should be included in the scope of claims.
Claims (7)
1. the method for a measuring blood concentration is characterized in that, the method for this measuring blood concentration comprises:
Import the simulation source relevant with blood sugar concentration to having in the amplifier circuit, wherein this amplifier circuit comprises a resistance, a reference resistance and a reference voltage;
Change this simulation source and become a digital signal by an analog signal conversion;
Handle this digital signal;
Export this digital signal with an ascending curve form, obtain maximum crest value according to the ascending curve of this digital signal; And
Try to achieve a blood glucose concentration value of this blood glucose solution in conjunction with a reference voltage level of a resistance value of a resistance value of this resistance, this reference resistance, this reference voltage and an output voltage values and this maximum crest value.
2. the method for measuring blood concentration as claimed in claim 1 is characterized in that, above-mentioned simulation source obtains after a chemical reaction via this blood glucose solution and the test piece with a catalyst.
3. the method for measuring blood concentration as claimed in claim 2 is characterized in that, above-mentioned chemical reaction comprises a redox reaction.
4. the method for measuring blood concentration as claimed in claim 1 is characterized in that, utilizes an analog front-end device to come the converting analogue source.
5. the method for measuring blood concentration as claimed in claim 1 is characterized in that, above-mentioned peak-peak was tried to achieve by a very first time of this ascending curve and the difference of an initial time, and wherein this difference is greater than zero.
6. the method for measuring blood concentration as claimed in claim 1 is characterized in that, after exporting this digital signal with the rising curve form, also is included in a meansigma methods of calculated complex group crest value after a default sample time.
7. the method for measuring blood concentration as claimed in claim 1 is characterized in that, export this digital signal with the rising curve form after, also comprise by the plural groups ascending curve and obtain the maximum crest value of plural groups and be made into comparison list with this output voltage values.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101463522A CN101368922B (en) | 2003-04-10 | 2003-04-10 | Method for judging blood sugar concentration |
| CNB031102980A CN100427025C (en) | 2003-04-10 | 2003-04-10 | Method for judging concentration of lood sugar |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031102980A CN100427025C (en) | 2003-04-10 | 2003-04-10 | Method for judging concentration of lood sugar |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101463522A Division CN101368922B (en) | 2003-04-10 | 2003-04-10 | Method for judging blood sugar concentration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1536353A CN1536353A (en) | 2004-10-13 |
| CN100427025C true CN100427025C (en) | 2008-10-22 |
Family
ID=34319662
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101463522A Expired - Fee Related CN101368922B (en) | 2003-04-10 | 2003-04-10 | Method for judging blood sugar concentration |
| CNB031102980A Expired - Fee Related CN100427025C (en) | 2003-04-10 | 2003-04-10 | Method for judging concentration of lood sugar |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008101463522A Expired - Fee Related CN101368922B (en) | 2003-04-10 | 2003-04-10 | Method for judging blood sugar concentration |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101900704A (en) * | 2010-07-26 | 2010-12-01 | 北京软测科技有限公司 | Method for improving blood measuring accuracy by insertion algorithm |
| CN102841117A (en) * | 2012-04-18 | 2012-12-26 | 江苏学府医疗科技有限公司 | Portable blood glucometer subsection statistical averaging and measuring method capable of improving detection accuracy |
| CN107255657B (en) * | 2017-06-07 | 2020-01-10 | 苏州大学 | Chaos coding and decoding method for blood sugar nondestructive test |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1025410C (en) * | 1989-10-28 | 1994-07-13 | 梁元锡 | Non-invasive method and apparatus for measuring blood glucose concent ration |
| WO1999044495A1 (en) * | 1998-03-02 | 1999-09-10 | Conarma Ab | A device for the determination of blood sugar |
| WO1999058050A1 (en) * | 1998-05-13 | 1999-11-18 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
| JP2002257782A (en) * | 2001-03-05 | 2002-09-11 | Nec Corp | Electrochemical sensor measuring device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4415896A1 (en) * | 1994-05-05 | 1995-11-09 | Boehringer Mannheim Gmbh | Analysis system for monitoring the concentration of an analyte in the blood of a patient |
-
2003
- 2003-04-10 CN CN2008101463522A patent/CN101368922B/en not_active Expired - Fee Related
- 2003-04-10 CN CNB031102980A patent/CN100427025C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1025410C (en) * | 1989-10-28 | 1994-07-13 | 梁元锡 | Non-invasive method and apparatus for measuring blood glucose concent ration |
| WO1999044495A1 (en) * | 1998-03-02 | 1999-09-10 | Conarma Ab | A device for the determination of blood sugar |
| WO1999058050A1 (en) * | 1998-05-13 | 1999-11-18 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
| JP2002257782A (en) * | 2001-03-05 | 2002-09-11 | Nec Corp | Electrochemical sensor measuring device |
Non-Patent Citations (8)
| Title |
|---|
| "便携式医学检测仪器的设计". 管文军.中国医疗器械杂志，第26卷第5期. 2002 |
| "医学临床诊断与生物传感器". 胡军.工业微生物，第26卷第2期. 1996 |
| "双酶电极测定血清中的葡萄糖的研究". 金利通等.华东师范大学学报（自然科学版），第2期. 1994 |
| "微电极葡萄糖传感器的研究". 虞淳.传感器技术，第6期. 1988 |
| "便携式医学检测仪器的设计". 管文军.中国医疗器械杂志，第26卷第5期. 2002 * |
| "医学临床诊断与生物传感器". 胡军.工业微生物，第26卷第2期. 1996 * |
| "双酶电极测定血清中的葡萄糖的研究". 金利通等.华东师范大学学报（自然科学版），第2期. 1994 * |
| "微电极葡萄糖传感器的研究". 虞淳.传感器技术，第6期. 1988 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101368922A (en) | 2009-02-18 |
| CN1536353A (en) | 2004-10-13 |
| CN101368922B (en) | 2010-12-15 |
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