CA2822025C - Metal salt compositions - Google Patents
Metal salt compositions Download PDFInfo
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- CA2822025C CA2822025C CA2822025A CA2822025A CA2822025C CA 2822025 C CA2822025 C CA 2822025C CA 2822025 A CA2822025 A CA 2822025A CA 2822025 A CA2822025 A CA 2822025A CA 2822025 C CA2822025 C CA 2822025C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
Described herein are compositions comprising combinations of metal salts, and methods of preparing and using the same.
Description
, , METAL SALT COMPOSITIONS
BACKGROUND
[0001] The amount of a given metal salt which can be incorporated into an oral care product is often limited as a result of unfavorable effects on the sensory experience of the user, for example, astringency, taste and mouth feel.
BACKGROUND
[0001] The amount of a given metal salt which can be incorporated into an oral care product is often limited as a result of unfavorable effects on the sensory experience of the user, for example, astringency, taste and mouth feel.
[0002] These limits on metal salt concentration have made it difficult to deliver an effective amount of a metal ion to the soft and/or hard tissue of the oral cavity using an oral care composition. Embodiments of the present invention provide compositions which address, inter alia, this problem.
SUMMARY
SUMMARY
[0003] In some embodiments, the present invention provides an oral care composition comprising: a first metal salt, having a solubility of greater than 0.001 g/100 mL in water at C; a second metal salt having a solubility of 0.001 g/100 mL, or less, in water at 20 C; and a free water content of greater than about 10%, by weight. In some embodiments, the first 15 metal salt and second metal salt are independently selected from a zinc salt, a stannous salt and a copper salt. In some embodiments, the second metal salt is present in an amount effective to provide a synergistic increase in delivery of the metal ion of the first or second metal salt.
[0003a] According to another aspect of the present invention, there is provided an oral care 20 composition comprising: a first metal salt, having a solubility of greater than 0.001 g/100 mL
in water at 20 C; a second metal salt, having a solubility of 0.001 g/100 mL, or less, in water at 20 C; and a free water content of greater than about 10%, by weight;
wherein the first metal salt and the second metal salt are in a single phase; and wherein the first metal salt is zinc citrate and the second metal salt is selected from zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide, and zinc sulfide; and wherein the composition comprises from 0.1% to 5% by weight, of the first metal salt; and from 0.05% to 2% by weight, of the second metal salt; and wherein the second metal salt is =
present in an amount effective to provide a synergistic increase in delivery of the metal ion of the first or second metal salt.
[0003a] According to another aspect of the present invention, there is provided an oral care 20 composition comprising: a first metal salt, having a solubility of greater than 0.001 g/100 mL
in water at 20 C; a second metal salt, having a solubility of 0.001 g/100 mL, or less, in water at 20 C; and a free water content of greater than about 10%, by weight;
wherein the first metal salt and the second metal salt are in a single phase; and wherein the first metal salt is zinc citrate and the second metal salt is selected from zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide, and zinc sulfide; and wherein the composition comprises from 0.1% to 5% by weight, of the first metal salt; and from 0.05% to 2% by weight, of the second metal salt; and wherein the second metal salt is =
present in an amount effective to provide a synergistic increase in delivery of the metal ion of the first or second metal salt.
[0004] Some embodiments provide a method of treating or preventing a disease or condition of the oral cavity comprising contacting an oral cavity surface of a patient in need thereof with any one of the compositions described herein.
DETAILED DESCRIPTION
DETAILED DESCRIPTION
[0005] As used throughout, ranges are used as a short hand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range.
la
la
[0006]
[0007] In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.
[0008] As used herein, the term "soluble metal salt" refers to a metal salt having a solubility of greater than 0.001 g/ 100 mL in water at 20 C.
[0009] As used herein, the term "insoluble metal salt" refers to a metal salt having a solubility of 0.001 g/100 mL, or less, in water at 20 C.
[0010] In some embodiments, the present invention provides an oral care composition comprising: a first metal salt, having a solubility of greater than 0.001 g/100 mL in water at 20 C; a second metal salt having a solubility of 0.001 g/100 mL, or less, in water at 20 C; and a free water content of greater than about 10%, by weight In some embodiments, the first metal salt and the second metal salt are independently selected from a zinc salt, a stannous salt and a copper salt.
[0011] In some embodiments, the second metal salt is present in an amount effective to provide a synergistic increase in delivery of the metal ion of the first or second metal salt In some embodiments, the second metal salt is present in an amount effective to provide a synergistic increase in the uptake of the metal ion of the first or second metal salt. In some embodiments, the delivery or uptake is synergistically increased in oral cavity soft tissue. In some embodiments, the delivery or uptake is synergistically increased in an oral cavity hard surface, e.g. a tooth. Some embodiments provide compositions wherein the second metal is present in an amount effective to provide a synergistic increase in delivery or uptake of the metal ion of the first metal salt.
[0012] In some embodiments, the first metal salt and the second metal salt are salts of the same metal.
[0013] In some embodiments, the first metal salt is selected from: zinc citrate, zinc chloride, zinc lactate, zinc nitrate, zinc acetate, zinc gluconate, zinc glycinate and zinc sulfate. In some embodiments, the zinc citrate is in the form of zinc citrate trihydrate. In some embodiments, the first metal salt is zinc citrate trihydrate.
[0014] In some embodiments, the second metal salt is selected from: zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide and zinc sulfide.
[0015] In some embodiments, the composition comprises from about 0.1 to about 5%, by weight, of the first metal salt; and from about 0.05 to about 2%, by weight, of the second metal salt. In some embodiments, the composition comprises from about 0.5 to about 4%, by weight, of the first metal salt; and from about 0.1 to about 1.5%, by weight, of the second metal salt. In other embodiments, the composition comprises from about 1 to about 3%, by weight, of the first metal salt; and from about 0.2 to about 0.75%, by weight, of the second metal salt.
[0016] Yet further embodiments provide compositions comprising: about 2%, by weight, of the first metal salt; and about 0.25%, by weight, of the second metal salt.
While other embodiments provide compositions comprising: about 2%, by weight, of the first metal salt; and about 0.5%, by weight, of the second metal salt.
While other embodiments provide compositions comprising: about 2%, by weight, of the first metal salt; and about 0.5%, by weight, of the second metal salt.
[0017] In some embodiments, the compositions further comprise one or more components selected from a fluoride ion source; a tartar control agent; a buffering agent; an antibacterial agent; an abrasive; and a combination of two or more thereof.
[0018] Some embodiments provide compositions wherein at least one of the one or more components is a fluoride ion source selected from: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and a combination of two or more thereof.
[0019] Other optional additives may be included. Among such optional additives, included are those provided in order to change appearance or aesthetic appeal, and/or to preserve the final product, and/or for taste/cosmetic appeal and/or as therapeutic and prophylactic ingredients for oral health, prevention or treatment of a condition or disorder of hard or soft tissue of the oral cavity, or the prevention or treatment of a physiological disorder or condition.
[0020] Some embodiments provide a composition wherein a preservative is present.
In some embodiments, the preservative is selected from parabens, potassium sorbate, benzyl alcohol, phenoxyethanol, polyaminopropryl biguanide, caprylic acid, sodium benzoate and cetylpyridinium chloride. In some embodiments, the preservative is present at a concentration of about 0.0001 to about 1%, by weight.
In some embodiments, the preservative is selected from parabens, potassium sorbate, benzyl alcohol, phenoxyethanol, polyaminopropryl biguanide, caprylic acid, sodium benzoate and cetylpyridinium chloride. In some embodiments, the preservative is present at a concentration of about 0.0001 to about 1%, by weight.
[0021] Colorants such as dyes may be food color additives presently certified under the Food Drug & Cosmetic Act for use in food and ingested drugs, including dyes such as FD&C Red No. 3 (sodium salt of tetraiodofluorescein), Food Red 17, disodium salt of 6-hydroxy-5-{(2-methoxy-5-methy1-4-sulphophenyl)azo}-2-n-aphthalenesulfonic acid, Food Yellow 13, sodium salt of a mixture of the mono and disulphonic acids of quinophtalone or 2-(2-quinoly1) indanedione, FD&C Yellow No.
(sodium salt of 4-p-sullophenylazo-1-p-sulfopheny1-5-hydroxypyrazole-3 carboxylic acid), FD&C Yellow No. 6 (sodium salt of p-sullophenylazo-B-naphto1-monosulfonate), FD&C Green No. 3 (disodium salt of 4-1[4-(N-ethyl-p-sulfobenzylamino)-phenyl]-(4-hydroxy-2-sulfoniumphenyl)-methylene)-[1-(N-ethyl-N-p-sulfobenzy1)-DELTA-3,5-cycl-ohexadienimine], FD&C Blue No. 1 (disodium salt of dibenzyldiethyl-diamino- triphenykarbinol trisullonic acid anhydrite), FD&C
Blue No. 2 (sodium salt of disulfonic acid of indigotin) and mixtures thereof in various proportions. Typically, colorants if included are present in very small quantities.
(sodium salt of 4-p-sullophenylazo-1-p-sulfopheny1-5-hydroxypyrazole-3 carboxylic acid), FD&C Yellow No. 6 (sodium salt of p-sullophenylazo-B-naphto1-monosulfonate), FD&C Green No. 3 (disodium salt of 4-1[4-(N-ethyl-p-sulfobenzylamino)-phenyl]-(4-hydroxy-2-sulfoniumphenyl)-methylene)-[1-(N-ethyl-N-p-sulfobenzy1)-DELTA-3,5-cycl-ohexadienimine], FD&C Blue No. 1 (disodium salt of dibenzyldiethyl-diamino- triphenykarbinol trisullonic acid anhydrite), FD&C
Blue No. 2 (sodium salt of disulfonic acid of indigotin) and mixtures thereof in various proportions. Typically, colorants if included are present in very small quantities.
[0022] Flavoring agents include, but are not limited to, natural and artificial flavors.
These flavorings may be chosen from synthetic flavor oils and flavoring aromatics, and/or oils, oleo resins and extracts derived from plants, leaves, flowers, fruits and so forth, and combinations thereof. Representative flavor oils include:
spearmint oil, cinnamon oil, peppermint oil, clove oil, bay oil, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, and oil of bitter almonds. These flavoring agents can be used individually or in admixture. Commonly used flavors include mints such as peppermint, artificial vanilla, cinnamon derivatives, and various fruit flavors, whether employed individually or in admixture. Generally, any flavoring agent or food additive, such as those described in Chemicals Used in Food Processing, publication 1274 by the National Academy of Sciences, pages 63-258, may be used.
Typically, flavoring agents, if included, are present at a concentration of from about 0.01 to about 1%, by weight. In some embodiments, the flavoring agent may be present at a concentration of about 0.2%, by weight.
These flavorings may be chosen from synthetic flavor oils and flavoring aromatics, and/or oils, oleo resins and extracts derived from plants, leaves, flowers, fruits and so forth, and combinations thereof. Representative flavor oils include:
spearmint oil, cinnamon oil, peppermint oil, clove oil, bay oil, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, and oil of bitter almonds. These flavoring agents can be used individually or in admixture. Commonly used flavors include mints such as peppermint, artificial vanilla, cinnamon derivatives, and various fruit flavors, whether employed individually or in admixture. Generally, any flavoring agent or food additive, such as those described in Chemicals Used in Food Processing, publication 1274 by the National Academy of Sciences, pages 63-258, may be used.
Typically, flavoring agents, if included, are present at a concentration of from about 0.01 to about 1%, by weight. In some embodiments, the flavoring agent may be present at a concentration of about 0.2%, by weight.
[0023] Sweeteners include both natural and artificial sweeteners. Suitable sweeteners include water soluble sweetening agents such as monosaccharides, disaccharides and polysaccharides such as xylose, ribose, glucose (dextrose), mannose, galactose, fructose (levulose), sucrose (sugar), maltose, water soluble artificial sweeteners such as the soluble saccharin salts, i.e., sodium or calcium saccharin salts, cyclamate salts, dipeptide based sweeteners, such a L-aspartic acid derived sweeteners, such as L-aspartyl-L-phenylalanine methyl ester (aspartame). In general, the effective amount of sweetener is utilized to provide the level of sweetness desired for a particular composition, will vary with the sweetener selected. This amount will normally be from about 0.001 to about 5%, by weight In some embodiments, the sweetener is sodium saccharin and is present at a concentration of about 0.01%, by weight.
[0024] Whitening agents, material which is effective to effect whitening of a tooth surface to which it is applied, such as hydrogen peroxide and urea peroxide, high cleaning silica, preservatives, silicones, and chlorophyll compounds may be incorporated into the compositions of the present invention. In various embodiments, the compositions of this invention comprise a peroxide whitening agent, comprising a peroxide compound. A peroxide compound is an oxidizing compound comprising a bivalent oxygen-oxygen group. Peroxide compounds include peroxides and hydropermddes, such as hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy adds, pharmaceutically-acceptable salts thereof, and mixtures thereof. Peroxides of alkali and alkaline earth metals include lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof. Organic peroxy compounds include carbamide peroxide (also known as urea hydrogen peroxide), glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, and monoperoxyphthalate, and mixtures thereof. Peroxy acids and their salts include organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as persulfate, dipersulfate, percarbonate, perphosphate, perborate and persilicate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof. In various embodiments, the peroxide compound comprises hydrogen peroxide, urea peroxide, sodium percarbonate and mixtures thereof. In some embodiments, the peroxide compound comprises hydrogen peroxide. In some embodiments, the peroxide compound consists essentially of hydrogen peroxide. In some embodiments a non-peroxide whitening agent may be provided. Whitening agents among those useful herein include non-peroxy compounds, such as chlorine dioxide, chlorites and hypochlorites. Chlorites and hypochlorites include those of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium. Non-peroxide whitening agents also include colorants, such as titanium dioxide and hydroxyapatite. One or more whitening agents are optionally present in a tooth-whitening effective total amount. In some embodiments the whitening agent is separated from the aqueous carrier. In some embodiments the whitening agent is separated from the aqueous carrier by encapsulation of the whitening agent.
[0025] Optionally, breath freshening agents may be provided. Any orally acceptable breath freshening agent can be used, including without limitation. One or more breath freshening agents are optionally present in a breath freshening effective total amount.
[0026] Other embodiments provide compositions wherein at least one of the one or more components is a tartar control agent. Tartar control agents among those useful herein include phosphates and polyphosphates (for example pyrophosphates), polyaminopropanesulfonic acid (AMPS), polyolefin sulfonates, polyolefin phosphates, diphosphonates such as azacycloalkane-2,2-diphosphonates (e.g., azacycloheptane-2,2-diphosphonic acid), N-methyl azacyclopentane-2,3-diphosphonic acid, ethane-1-hydroxy-1,1-diphosphonic acid (EHDP) and ethane-1-amino-1,1-diphosphonate, phosphonoalkane carboxylic acids and salts of any of these agents, for example their alkali metal and ammonium salts. Useful inorganic phosphate and polyphosphate salts include monobasic, dibasic and tribasic sodium phosphates, sodium tripolyphosphate, tetrapolyphosphate, mono-, di-, tri- and tetrasodium pyrophosphates, sodium trimetaphosphate, sodium hexametaphosphate and mixtures thereof, wherein sodium can optionally be replaced by potassium or ammonium. Other useful anticalculus agents include polycarboxylate polymers and polyvinyl methyl ether/ maleic anhydride (PVME/ MA) copolymers, such as those available under the GantrezTM brand from ISP, Wayne, N.J. In some embodiments, a phosphate is present at a concentration of from about 0.01 to about 10%, by weight. In some embodiments, a phosphate is present at a concentration of from about 1%, by weight.
[0027] Some embodiments provide compositions wherein a buffering agent is present. In some embodiments, sodium phosphate monobasic is present at a concentration of from about 0.01 to about 5%, by weight. In some embodiments, sodium phosphate monobasic phosphate is present at a concentration of about 1%, by weight. In some embodiments, sodium phosphate dibasic is present at a concentration of from about 0.01 to about 5%, by weight. In some embodiments, sodium phosphate dibasic phosphate is present at a concentration of about 0.15%, by weight.
[0028] Other optional additives include antimicrobial (e.g., antibacterial) agents. Any orally acceptable antimicrobial agent can be used, including Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol); 8-hydroxyquinoline and salts thereof, zinc and stannous ion sources such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate; copper (II) compounds such as copper (II) chloride, fluoride, sulfate and hydroxide; phthalic acid and salts thereof such as magnesium monopotassium phthalate; sanguinarine; quaternary ammonium compounds, such as alkylpyridinium chlorides (e.g., cetylpyridinium chloride (CPC), combinations of CPC with zinc and/or enzymes, tetradecylpyridinium chloride, and N-tetradecy1-4-ethylpyridinium chloride); bisguanides, such as chlorhexidine digluconate, hexetidine, octenidine, ale;ddine; halogenated bisphenolic compounds, such as 22' methylenebis-(4-chloro-6-bromophenol);
benzalkonium chloride; salicylanliide, domiphen bromide; iodine; sulfonamides;
bisbiguanides; phenolics; piperidino derivatives such as delmopinol and octapinol;
magnolia extract; grapeseed extract; thymol; eugenol; menthol; geraniol;
carvacrol;
citral; eucalyptol; catethol; 4-allykatethol; hexyl resorcinol; methyl salicylate;
antibiotics such as augmentin, ammticillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanarnycin and clindamycin; and mixtures thereof. A
further illustrative list of useful antibacterial agents is provided in U.S.
Pat. No.
5,776,435, Gaffar, et al., issued Jul. 7, 1998. In some embodiments, the antimicrobial agent is present at a concentration of from about 0.001 to about 1%, by weight. In some embodiments, the antimicrobial agent is cetylpyridinium chloride. In some embodiments, cetylpyridinium chloride is present at a concentration of from about 0.001 to about 1%, by weight. In other embodiments, cetylpyridinium chloride is present at a concentration of about 0.05%, by weight.
benzalkonium chloride; salicylanliide, domiphen bromide; iodine; sulfonamides;
bisbiguanides; phenolics; piperidino derivatives such as delmopinol and octapinol;
magnolia extract; grapeseed extract; thymol; eugenol; menthol; geraniol;
carvacrol;
citral; eucalyptol; catethol; 4-allykatethol; hexyl resorcinol; methyl salicylate;
antibiotics such as augmentin, ammticillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanarnycin and clindamycin; and mixtures thereof. A
further illustrative list of useful antibacterial agents is provided in U.S.
Pat. No.
5,776,435, Gaffar, et al., issued Jul. 7, 1998. In some embodiments, the antimicrobial agent is present at a concentration of from about 0.001 to about 1%, by weight. In some embodiments, the antimicrobial agent is cetylpyridinium chloride. In some embodiments, cetylpyridinium chloride is present at a concentration of from about 0.001 to about 1%, by weight. In other embodiments, cetylpyridinium chloride is present at a concentration of about 0.05%, by weight.
[0029] Antioxidants are another class of optional additives. Any orally acceptable antioxidant can be used, including butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and mixtures thereof.
[0030] Also optional, a saliva stimulating agent, useful for example in amelioration of dry mouth, may be included. Any orally acceptable saliva stimulating agent can be used, including without limitation food adds such as citric, lactic, malic, succinic, ascorbic, adipic, fumaric, and tartaric acids, and mixtures thereof. One or more saliva stimulating agents are optionally present in a saliva stimulating effective total amount.
[0031] Optionally, an antiplaque (e.g., plaque disrupting) agent may be included.
Any orally acceptable antiplaque agent can be used, including without limitation stannous, copper, magnesium and strontium salts, dimethicone copolyols such as cetyl dimethicone copolyol, papain, glucoamylase, glucose oxidase, urea, calcium lactate, calcium glycerophosphate, strontium polyaaylates and mixtures thereof.
Any orally acceptable antiplaque agent can be used, including without limitation stannous, copper, magnesium and strontium salts, dimethicone copolyols such as cetyl dimethicone copolyol, papain, glucoamylase, glucose oxidase, urea, calcium lactate, calcium glycerophosphate, strontium polyaaylates and mixtures thereof.
[0032] Optional desensitizing agents include potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate, strontium salts, and mixtures thereof.
[0033] Optional additives also include vitamins, herbs and proteins. Vitamins include Vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, pantheon, retinyl palmitate, tocopherol acetate, and mixtures thereof.
Herbs such as Chamornilla recutita, Men tha piperita, Salvia officinalis, and Cornmiphora myrrha may optionally be included. Suitable proteins include milk proteins and enzymes such as peroxide-producing enzymes, amylase, plaque-disrupting agents such as papain glucoamylase, glucose coddase, and "next generation" enzymes.
Herbs such as Chamornilla recutita, Men tha piperita, Salvia officinalis, and Cornmiphora myrrha may optionally be included. Suitable proteins include milk proteins and enzymes such as peroxide-producing enzymes, amylase, plaque-disrupting agents such as papain glucoamylase, glucose coddase, and "next generation" enzymes.
[0034] In some embodiments, the composition has a free water content of greater than about 10%, by weight. In some embodiments, the composition has a free water content of greater than about 11%, by weight In other embodiments, the composition has a free water content of greater than about 12%, by weight Yet other embodiments provide compositions wherein the free water content is greater than about 13%, by weight. Still other embodiments provide compositions having a free water content of greater than about 14%, by weight. In some embodiments, the composition has a free water content of greater than about 15%, by weight.
While other embodiments provide compositions have a free water content of greater than about 16%, by weight. In some embodiments, the composition has a free water content of about 17%, by weight. In some embodiments, the composition has a free water content of greater than about 17%, by weight. In some embodiments, the composition has a free water content of from about 10% to about 20%, by weight.
While other embodiments provide compositions have a free water content of greater than about 16%, by weight. In some embodiments, the composition has a free water content of about 17%, by weight. In some embodiments, the composition has a free water content of greater than about 17%, by weight. In some embodiments, the composition has a free water content of from about 10% to about 20%, by weight.
[0035] In some embodiments, the soluble metal salt and insoluble metal salt are not contained in a film. In some embodiments, the soluble metal salt and insoluble metal salt are in a single phase.
[0036] Some embodiments provide a method of treating or preventing a disease or condition of the oral cavity comprising contacting an oral cavity surface of a patient in need thereof with any one of the compositions described herein. In other embodiments, the disease or condition of the oral cavity is halitosis. In some embodiments, the present invention provides a method of reducing volatile sulfur compounds in the oral cavity of a subject in need thereof. In further embodiments, the present invention provides a method for increasing the delivery of a metal ion to an oral cavity surface.
[0031 In certain embodiments, the compositions described herein can be used, for example, for cavity prevention, whitening, plaque prevention or reduction, gingivitis prevention or reduction, tartar control, breath malodor prevention or reduction, and stain prevention.
[0038] The specific composition of the carrier preferably depends on the intended use of the composition. In various embodiments, the carrier is aqueous, comprising from about 5 to about 95%, by weight, water or from about 10 to about 70%, by weight, water. In other embodiments, the carrier is substantially non-aqueous.
In a dentifrice carrier, water content can be from about 5 to about 70%, from about 10 to about 50%, or from about 20 to about 40%, by weight.
[0039] The carrier may comprise any of a variety of materials, including emulsifiers, thickeners, fillers, and preservatives. In some embodiments, the carrier may include a functional or active material, such as those described above.
[0040] In some embodiments, the carrier comprises a humectant, such as glycerin, sorbitol or an alkylene glycol such as polyethylene glycol or propylene glycol. In some embodiments, the carrier comprises a humectant at a level of from about 10 to about 80% by weight, or about 20 to about 60% by weight of the composition.
Carrier compositions among those useful herein are disclosed in U.S. Patents 5,695,746 to Garlick, Jr., et al. and 4,839,157 to Mei-King Ng et al.
[0041] Thickeners or gelling agents useful herein include inorganic, natural or synthetic thickeners or gelling agents. In some configurations, the carrier comprises the thickener and gelling agent at total levels of from about 0.1 to about 15%
by weight, or from about 0.4 to about 10% by weight of the composition. Examples of thickeners and gelling agents useful herein include inorganic thickening silicas such as: an amorphous silica, for example Zeodent 165 (Huber Corporation); Irish moss;
iota-carrageenan; gum tragacanth; or polyvinylpyrrolidone.
[0042] In certain embodiments, the carrier comprises an abrasive or polishing agent, such as a silica, a calcined alumina, sodium bicarbonate, calcium carbonate, dicalcium phosphate or calcium pyrophosphate. In various embodiments, the carrier is clear. In various embodiments, the carrier comprises an abrasive at a level of from about 5 to about 70% by weight of the composition.
[0043] In some embodiments, the compositions comprise a surfactant or mixture of surfactants. Surfactants among those useful herein include water-soluble salts of at least one higher fatty acid monoglyceride monosullate, such as the sodium salt of the monsulfated monoglyceride of hydrogenated coconut oil fatty acids;
cocamidopropyl betaine; a higher alkyl sulfate such as sodium lauryl sulfate;
an alkyl aryl sulfonate such as sodium dodecyl benzene sulfonate; a higher alkyl sulloacetate; sodium lauryl sulfoacetate; a higher fatty acid ester of 1,2-dihydroxy propane sulfonate; and a substantially saturated higher aliphatic acyl amides of a lower aliphatic amino carboxylic acid, such as those having 12 to 16 carbons in the fatty acid, alkyl or acyl radicals; and mixtures thereof. Amides can be, for example, N-lauroyl sarcosine, and the sodium, potassium, and ethanolamine salts of N-= 62301-3316 lauroyl, N-myristoyl, or N-palmitoyl sarcosine. In various embodiments, the surfactant is present at a concentration of from about 0.3 to about 5% by weight of composition, or about 0.5 to about 3% by weight of composition.
[0044] Compositions as described herein can be prepared according to methods readily known to those skilled in the art.
[0045] Embodiments of the present invention are further described in the following examples. The examples are merely illustrative and do not in any way limit the scope of the invention as described and daimed.
EXAMPLES
Example 1 [00461 Table 1 (below) provides the formulation for exemplary compositions of the present invention.
Table 1 Ingredient % w/w GantreZ(13% solution) 11.5 Glycerin 11.5 Zeodent 105 10 Zeodent 114 10 Polyethylene glycol 3 Tetrapotassium pyrophosphate 2.4 Zinc citrate trihythate 0.1 - 5 Zeodent 165 1.8 Sodium lauryl sulfate 1.5 Sodium hydroxide 1.3 Flavor 1.2 Titanium dioxide 1 Sodium monofluorophosphate 0.8 Sodium CMC 0.6 Carrageenan 0.4 Sodium saccharin 0.3 Zinc oxide 0.05 - 2 Water 17.6 Sorbitol q.s.
Example 2 [0047] The delivery of zinc from exemplary compositions of the present invention to hydroxyapatite was compared to zinc delivery from compositions containing either a soluble or insoluble metal salt alone. The evaluation was performed using the following experimental procedure.
[0048] Compositions were diluted with water (1:2) to form a slurry. A saliva coated hydroxyapatite disk was added to the slurry. The disk remained in the slurry for about 10 minutes and was then rinsed three times with 5 mL of water. The disk was then digested with nitric acid and total zinc was measured by atomic absorption spectroscopy.
[0049] The data described in Table 2 (below) demonstrates that the addition of an insoluble metal salt (e.g. zinc oxide) to a composition comprising a soluble metal salt (e.g. zinc citrate) synergistically increases the delivery of the metal (zinc) to hydroxyapatite.
Table 2 Formula Zinc uptake Total Zinc (%) Soluble Zinc (%) (ug/disk) 2% Zn Citrate 33.7 + 5.0 0.71 0.29 2% Zn Citrate + 69.0 + 8.5 0.88 0.23 0.25% ZnO
2% Zn Citrate + 135.9 + 11.8 1.13 0.36 0.5% ZnO
1.0% ZnO in silica base 5.9 + 0.4 0.60 0.07 Example 3 [0050] The uptake of zinc in the pig tongue and vitro skin was evaluated using the test procedures below.
Pig Tongue [0051] Remove muscle portion of the tongue. Cut into 12 mm circles with cork borer. Glue circles to glass plates. Transfer into 24-well plate. Incubate with 1 mL of PBS buffer for 30 minutes at room temperature. Aspirate buffer, incubate for 2 minutes with 1 mL of 1:2 slurry of studied paste at 37 C. Aspirate slurry and rinse tissue 3x with 2 mL of deionized water. Transfer into a tube and digest with 1 mL of conc nitric acid (HNO3) overnight. Fill up to 15 mL with deionized water.
Centrifuge for 30 minutes at 2500 RPM to obtain clear supernatant for submission for zinc analysis.
Vitro-SkinTM
[00521 Cut Vitro-skin (IMS Inc., Portland, ME) into uniform circles of diameter between 10 to 14 mm. Cork borer could be used. The exact diameter will be necessary to calculate uptake per square centimeter. To remove the silicone coating, rinse the Vitro-skin circles (in bulk) 3 times with hexanes for 5 minutes. Air dry to evaporate hexanes. Soak Vitro-skin in sterilized and cleared saliva overnight in disposable polystyrene Falcon tube (mfc. code 352057). Use 1 mL of saliva per tissue.
Perform in triplicate. Aspirate saliva, add 1 mL of 1:2 paste slurry and incubate for 2 minutes in 37 C water bath. Operate quickly as uptake depends on exposure time at all temperatures. Aspirate the slurry and rinse 3-times with 5 mL of DI water for 10 seconds each. Use vortex for rinsing (max speed). Transfer the tissue into new polystyrene Falcon tube (mfc. code 352095). Process all samples at same speed.
Add 1 mL of concentrated nitric acid to the tissue and incubate overnight The tissue should dissolve completely. Add enough deionized water to fill it to 10 mL
line.
Shake well. Do not filter. Submit for zinc analysis. The obtained level of zinc (typically in ppm) must be multiplied by the total volume (10x in this case) to get irg of zinc per tissue (UT). Table 3 (below) describes the data generated in the pig tongue and vitro-skin experiments described herein.
[0053] To calculate uptake of zinc per square centimeter, the following formula can be used: UR = 2*UT / (red2) [lig/ cm2]
wherein: UR = (relative) zinc uptake per square centimeter of Vitro-skin (both sides) UT = zinc uptake per tissue =
d = diameter of the tissue in centimeters Table 3 Formula Zn uptake to pig Zn uptake to Vitro- Soluble tongue (pg/cm.2) skin (pg/c.m2) zinc (/o) 2% Zn Citrate 13.5 1.1 1.8 0.5 0.24 2% Zn C.itrate+0.5% ZnO 25.4 7.4 12.0 0.3 0.33 1% ZnO not available 2.2 0.2 0.07 3% Zn Lactate 21.2 5.8 6.9 1.0 0.52 [0054] Pig tongue is a suitable tissue representing a human tongue. Vitro-skin is a commercial product used as a standard for in-vitro skin related experiments.
[0055] The data described in Table 3 (above) demonstrates that metal salt uptake is synergistically increased by exemplary compositions of the present invention, which contain a combination of a soluble metal salt (e.g. zinc citrate) and an insoluble metal salt (e.g. zinc oxide).
[0056] As those skilled in the art will appreciate, numerous changes and modifications may be made to the embodiments described herein without departing from the invention. The scope of the claims should not be limited by the preferred embodiments set forth in the examples, but should be given the broadest interpretation consistent with the description as a whole.
[0031 In certain embodiments, the compositions described herein can be used, for example, for cavity prevention, whitening, plaque prevention or reduction, gingivitis prevention or reduction, tartar control, breath malodor prevention or reduction, and stain prevention.
[0038] The specific composition of the carrier preferably depends on the intended use of the composition. In various embodiments, the carrier is aqueous, comprising from about 5 to about 95%, by weight, water or from about 10 to about 70%, by weight, water. In other embodiments, the carrier is substantially non-aqueous.
In a dentifrice carrier, water content can be from about 5 to about 70%, from about 10 to about 50%, or from about 20 to about 40%, by weight.
[0039] The carrier may comprise any of a variety of materials, including emulsifiers, thickeners, fillers, and preservatives. In some embodiments, the carrier may include a functional or active material, such as those described above.
[0040] In some embodiments, the carrier comprises a humectant, such as glycerin, sorbitol or an alkylene glycol such as polyethylene glycol or propylene glycol. In some embodiments, the carrier comprises a humectant at a level of from about 10 to about 80% by weight, or about 20 to about 60% by weight of the composition.
Carrier compositions among those useful herein are disclosed in U.S. Patents 5,695,746 to Garlick, Jr., et al. and 4,839,157 to Mei-King Ng et al.
[0041] Thickeners or gelling agents useful herein include inorganic, natural or synthetic thickeners or gelling agents. In some configurations, the carrier comprises the thickener and gelling agent at total levels of from about 0.1 to about 15%
by weight, or from about 0.4 to about 10% by weight of the composition. Examples of thickeners and gelling agents useful herein include inorganic thickening silicas such as: an amorphous silica, for example Zeodent 165 (Huber Corporation); Irish moss;
iota-carrageenan; gum tragacanth; or polyvinylpyrrolidone.
[0042] In certain embodiments, the carrier comprises an abrasive or polishing agent, such as a silica, a calcined alumina, sodium bicarbonate, calcium carbonate, dicalcium phosphate or calcium pyrophosphate. In various embodiments, the carrier is clear. In various embodiments, the carrier comprises an abrasive at a level of from about 5 to about 70% by weight of the composition.
[0043] In some embodiments, the compositions comprise a surfactant or mixture of surfactants. Surfactants among those useful herein include water-soluble salts of at least one higher fatty acid monoglyceride monosullate, such as the sodium salt of the monsulfated monoglyceride of hydrogenated coconut oil fatty acids;
cocamidopropyl betaine; a higher alkyl sulfate such as sodium lauryl sulfate;
an alkyl aryl sulfonate such as sodium dodecyl benzene sulfonate; a higher alkyl sulloacetate; sodium lauryl sulfoacetate; a higher fatty acid ester of 1,2-dihydroxy propane sulfonate; and a substantially saturated higher aliphatic acyl amides of a lower aliphatic amino carboxylic acid, such as those having 12 to 16 carbons in the fatty acid, alkyl or acyl radicals; and mixtures thereof. Amides can be, for example, N-lauroyl sarcosine, and the sodium, potassium, and ethanolamine salts of N-= 62301-3316 lauroyl, N-myristoyl, or N-palmitoyl sarcosine. In various embodiments, the surfactant is present at a concentration of from about 0.3 to about 5% by weight of composition, or about 0.5 to about 3% by weight of composition.
[0044] Compositions as described herein can be prepared according to methods readily known to those skilled in the art.
[0045] Embodiments of the present invention are further described in the following examples. The examples are merely illustrative and do not in any way limit the scope of the invention as described and daimed.
EXAMPLES
Example 1 [00461 Table 1 (below) provides the formulation for exemplary compositions of the present invention.
Table 1 Ingredient % w/w GantreZ(13% solution) 11.5 Glycerin 11.5 Zeodent 105 10 Zeodent 114 10 Polyethylene glycol 3 Tetrapotassium pyrophosphate 2.4 Zinc citrate trihythate 0.1 - 5 Zeodent 165 1.8 Sodium lauryl sulfate 1.5 Sodium hydroxide 1.3 Flavor 1.2 Titanium dioxide 1 Sodium monofluorophosphate 0.8 Sodium CMC 0.6 Carrageenan 0.4 Sodium saccharin 0.3 Zinc oxide 0.05 - 2 Water 17.6 Sorbitol q.s.
Example 2 [0047] The delivery of zinc from exemplary compositions of the present invention to hydroxyapatite was compared to zinc delivery from compositions containing either a soluble or insoluble metal salt alone. The evaluation was performed using the following experimental procedure.
[0048] Compositions were diluted with water (1:2) to form a slurry. A saliva coated hydroxyapatite disk was added to the slurry. The disk remained in the slurry for about 10 minutes and was then rinsed three times with 5 mL of water. The disk was then digested with nitric acid and total zinc was measured by atomic absorption spectroscopy.
[0049] The data described in Table 2 (below) demonstrates that the addition of an insoluble metal salt (e.g. zinc oxide) to a composition comprising a soluble metal salt (e.g. zinc citrate) synergistically increases the delivery of the metal (zinc) to hydroxyapatite.
Table 2 Formula Zinc uptake Total Zinc (%) Soluble Zinc (%) (ug/disk) 2% Zn Citrate 33.7 + 5.0 0.71 0.29 2% Zn Citrate + 69.0 + 8.5 0.88 0.23 0.25% ZnO
2% Zn Citrate + 135.9 + 11.8 1.13 0.36 0.5% ZnO
1.0% ZnO in silica base 5.9 + 0.4 0.60 0.07 Example 3 [0050] The uptake of zinc in the pig tongue and vitro skin was evaluated using the test procedures below.
Pig Tongue [0051] Remove muscle portion of the tongue. Cut into 12 mm circles with cork borer. Glue circles to glass plates. Transfer into 24-well plate. Incubate with 1 mL of PBS buffer for 30 minutes at room temperature. Aspirate buffer, incubate for 2 minutes with 1 mL of 1:2 slurry of studied paste at 37 C. Aspirate slurry and rinse tissue 3x with 2 mL of deionized water. Transfer into a tube and digest with 1 mL of conc nitric acid (HNO3) overnight. Fill up to 15 mL with deionized water.
Centrifuge for 30 minutes at 2500 RPM to obtain clear supernatant for submission for zinc analysis.
Vitro-SkinTM
[00521 Cut Vitro-skin (IMS Inc., Portland, ME) into uniform circles of diameter between 10 to 14 mm. Cork borer could be used. The exact diameter will be necessary to calculate uptake per square centimeter. To remove the silicone coating, rinse the Vitro-skin circles (in bulk) 3 times with hexanes for 5 minutes. Air dry to evaporate hexanes. Soak Vitro-skin in sterilized and cleared saliva overnight in disposable polystyrene Falcon tube (mfc. code 352057). Use 1 mL of saliva per tissue.
Perform in triplicate. Aspirate saliva, add 1 mL of 1:2 paste slurry and incubate for 2 minutes in 37 C water bath. Operate quickly as uptake depends on exposure time at all temperatures. Aspirate the slurry and rinse 3-times with 5 mL of DI water for 10 seconds each. Use vortex for rinsing (max speed). Transfer the tissue into new polystyrene Falcon tube (mfc. code 352095). Process all samples at same speed.
Add 1 mL of concentrated nitric acid to the tissue and incubate overnight The tissue should dissolve completely. Add enough deionized water to fill it to 10 mL
line.
Shake well. Do not filter. Submit for zinc analysis. The obtained level of zinc (typically in ppm) must be multiplied by the total volume (10x in this case) to get irg of zinc per tissue (UT). Table 3 (below) describes the data generated in the pig tongue and vitro-skin experiments described herein.
[0053] To calculate uptake of zinc per square centimeter, the following formula can be used: UR = 2*UT / (red2) [lig/ cm2]
wherein: UR = (relative) zinc uptake per square centimeter of Vitro-skin (both sides) UT = zinc uptake per tissue =
d = diameter of the tissue in centimeters Table 3 Formula Zn uptake to pig Zn uptake to Vitro- Soluble tongue (pg/cm.2) skin (pg/c.m2) zinc (/o) 2% Zn Citrate 13.5 1.1 1.8 0.5 0.24 2% Zn C.itrate+0.5% ZnO 25.4 7.4 12.0 0.3 0.33 1% ZnO not available 2.2 0.2 0.07 3% Zn Lactate 21.2 5.8 6.9 1.0 0.52 [0054] Pig tongue is a suitable tissue representing a human tongue. Vitro-skin is a commercial product used as a standard for in-vitro skin related experiments.
[0055] The data described in Table 3 (above) demonstrates that metal salt uptake is synergistically increased by exemplary compositions of the present invention, which contain a combination of a soluble metal salt (e.g. zinc citrate) and an insoluble metal salt (e.g. zinc oxide).
[0056] As those skilled in the art will appreciate, numerous changes and modifications may be made to the embodiments described herein without departing from the invention. The scope of the claims should not be limited by the preferred embodiments set forth in the examples, but should be given the broadest interpretation consistent with the description as a whole.
Claims (18)
1. An oral care composition comprising:
a first metal salt, having a solubility of greater than 0.001 g/100 mL in water at 20°C;
a second metal salt, having a solubility of 0.001 g/100 mL, or less, in water at 20°C; and a free water content of greater than about 10%, by weight;
wherein the first metal salt and the second metal salt are in a single phase;
and wherein the first metal salt is zinc citrate and the second metal salt is selected from zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide, and zinc sulfide; and wherein the composition comprises from 0.1% to 5% by weight, of the first metal salt; and from 0.05% to 2% by weight, of the second metal salt; and wherein the second metal salt is present in an amount effective to provide a synergistic increase in delivery of the metal ion of the first or second metal salt.
a first metal salt, having a solubility of greater than 0.001 g/100 mL in water at 20°C;
a second metal salt, having a solubility of 0.001 g/100 mL, or less, in water at 20°C; and a free water content of greater than about 10%, by weight;
wherein the first metal salt and the second metal salt are in a single phase;
and wherein the first metal salt is zinc citrate and the second metal salt is selected from zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide, and zinc sulfide; and wherein the composition comprises from 0.1% to 5% by weight, of the first metal salt; and from 0.05% to 2% by weight, of the second metal salt; and wherein the second metal salt is present in an amount effective to provide a synergistic increase in delivery of the metal ion of the first or second metal salt.
2. The composition of claim 1 wherein the second metal salt is zinc oxide.
3. The composition of claim 1, comprising:
from 0.5 to 4%, by weight, of said first metal salt; and from 0.1 to 1.5%, by weight, of said second metal salt.
from 0.5 to 4%, by weight, of said first metal salt; and from 0.1 to 1.5%, by weight, of said second metal salt.
4. The composition of claim 3, comprising:
from 1 to 3%, by weight, of said first metal salt; and from 0.2 to 0.75%, by weight, of said second metal salt.
from 1 to 3%, by weight, of said first metal salt; and from 0.2 to 0.75%, by weight, of said second metal salt.
5. The composition of claim 4, comprising:
2%, by weight, of said first metal salt; and 0.25%, by weight, of said second metal salt.
2%, by weight, of said first metal salt; and 0.25%, by weight, of said second metal salt.
6. The composition of claim 4, comprising:
2%, by weight, of said first metal salt; and 0.5%, by weight, of said second metal salt.
2%, by weight, of said first metal salt; and 0.5%, by weight, of said second metal salt.
7. The composition of claim 1, wherein the second metal salt is selected from: zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide, and zinc sulfide; and the composition comprises from about .1 to about 5%, by weight, of said first metal salt; and from about 0.5 to about 2%, by weight, of said second metal salt.
8. The composition of claim 7, comprising: from 1 to 3%, by weight, of said first metal salt; and from 0.2 to 0.75%, by weight, of said second metal salt.
9. The composition of any one of claims 1 to 8, further comprising one of more components selected from a fluoride ion source; a tartar control agent; a buffering agent; an antibacterial agent; an abrasive; and a combination of two or more thereof.
10. The composition of claim 9, wherein at least one of the one or more components is a fluoride ion source selected from: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and a combination of two or more thereof.
11. The composition of claim 9 or claim 10, wherein at least one of the one or more components is a tartar control agent selected from: sodium tripolyphosphate, sodium tetrapolyphosphate, mono-, di-, tri- and tetrasodium pyrophosphates, sodium trimetaphosphate, sodium hexametaphosphate; potassium tripolyphosphate, potassium tetrapolyphosphate, mono-, di-, tri- and tetrapotassium pyrophosphates, potassium trimetaphosphate, potassium hexametaphosphate; and a combination of two or more thereof.
12. The composition of any one of claims 1 to 11, wherein the composition comprises greater than 15%, by weight, free water.
13. The composition of any one of claims 1 to 12, for use in treating or preventing a disease or condition of the oral cavity, and formulated for contacting an oral cavity surface of a patient in need thereof.
14. The composition of claim 13, wherein the disease or condition of the oral cavity is halitosis.
15. Use of the composition of any one of claims 1 to 12 in the manufacture of a medicament for the treatment or prevention of a disease or condition of the oral cavity.
16. Use according to claim 15, wherein the disease or condition of the oral cavity is halitosis.
17. Use of the composition of any one of claims 1 to 12 for the treatment or prevention of a disease or condition of the oral cavity.
18. Use according to claim 17, wherein the disease or condition of the oral cavity is halitosis.
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Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012396295B2 (en) * | 2012-12-05 | 2015-08-20 | Colgate-Palmolive Company | Zinc phosphate containing compositions |
US10494589B2 (en) | 2012-12-19 | 2019-12-03 | Colgate-Palmolive Company | Method for indicating time for washing or indicating delivery of antibacterial agent |
WO2014098821A1 (en) * | 2012-12-19 | 2014-06-26 | Colgate-Palmolive Company | Method for indicating time for washing or indicating delivery of antibacterial agent |
EP2934693B2 (en) | 2012-12-24 | 2021-10-27 | Colgate-Palmolive Company | Oral care composition |
CN104721063B (en) * | 2013-12-19 | 2018-05-08 | 高露洁-棕榄公司 | Dentrifice composition comprising zinc oxide and zinc citrate |
CN109908017A (en) * | 2013-12-19 | 2019-06-21 | 高露洁-棕榄公司 | Oral care composition |
CN104721226B (en) | 2013-12-19 | 2019-12-24 | 高露洁-棕榄公司 | Oral care compositions |
WO2015171837A1 (en) | 2014-05-09 | 2015-11-12 | The Procter & Gamble Company | Oral compositions containing zinc |
WO2016100381A1 (en) | 2014-12-16 | 2016-06-23 | Colgate-Palmolive Company | Metal salt compositions |
RU2699370C2 (en) | 2014-12-26 | 2019-09-05 | Колгейт-Палмолив Компани | Compositions in form of dentifrice with low water content |
CN107427423A (en) * | 2015-03-30 | 2017-12-01 | 荷兰联合利华有限公司 | Solid oral care composition |
EP3244872B1 (en) | 2015-07-01 | 2021-05-12 | Colgate-Palmolive Company | Oral care compositions and methods of use |
US10226407B2 (en) | 2015-12-30 | 2019-03-12 | Colgate-Palmolive Company | Oral care compositions |
MX2018007866A (en) | 2015-12-30 | 2018-08-27 | Colgate Palmolive Co | Personal care compositions. |
BR112018012947B1 (en) | 2015-12-30 | 2021-08-31 | Colgate-Palmolive Company | COMPOSITIONS FOR PERSONAL HYGIENE |
AU2016380275C1 (en) | 2015-12-30 | 2019-11-28 | Colgate-Palmolive Company | Oral care compositions |
CN106994103B (en) * | 2016-01-26 | 2021-08-10 | 白育纶 | Mouthwash composition |
MX2020004498A (en) | 2016-06-24 | 2022-06-09 | Colgate Palmolive Co | Oral care compositions and methods of use. |
BR112018005753B1 (en) * | 2016-06-24 | 2022-06-21 | Colgate-Palmolive Company | Composition for oral hygiene |
CN108024916B (en) * | 2016-06-24 | 2021-10-01 | 高露洁-棕榄公司 | Oral care compositions and methods of use |
CA3045782A1 (en) * | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
US10058493B2 (en) | 2016-12-21 | 2018-08-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
WO2019183876A1 (en) * | 2018-03-29 | 2019-10-03 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
MX2021007100A (en) | 2018-12-20 | 2021-08-11 | Colgate Palmolive Co | Oral care composition comprising zinc and an amino acid for treating symptoms of a gastric disorder in the oral cavity. |
EP3883529A1 (en) * | 2018-12-26 | 2021-09-29 | Colgate-Palmolive Company | Oral care compositions |
EP4034072A4 (en) | 2019-09-25 | 2023-11-08 | Church & Dwight Co., Inc. | Oral care composition |
WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
WO2021067994A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Fluoride-free anticavity oral care compositions |
BR112022018690A2 (en) | 2020-03-27 | 2022-11-01 | Colgate Palmolive Co | ORAL HYGIENE COMPOSITIONS AND USE METHODS |
CN116234530A (en) | 2020-07-31 | 2023-06-06 | 高露洁-棕榄公司 | Method for producing an oral care composition |
AU2022283265A1 (en) | 2021-05-25 | 2023-11-23 | Colgate-Palmolive Company | Oral care compositions |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1806733A (en) * | 1931-05-26 | Signors to acme pishing tool co | ||
US3622622A (en) | 1967-11-03 | 1971-11-23 | Parke Davis & Co | {60 -{8 p-(dimethylaminoalkoxy) phenyl{9 -{60 {40 -nitro-4-methoxystilbene compounds and methods for their production |
US3624199A (en) * | 1969-04-21 | 1971-11-30 | James Norfleet | Dental cream |
SE359027B (en) * | 1969-04-21 | 1973-08-20 | Colgate Palmolive Co | |
US3622662A (en) * | 1969-04-21 | 1971-11-23 | Colgate Palmolive Co | Stable dental cream |
US4154815A (en) | 1970-04-01 | 1979-05-15 | Lever Brothers Company | Zinc and enzyme toothpowder dentifrice |
JPS5019515B2 (en) | 1971-09-21 | 1975-07-08 | ||
JPS5146375B2 (en) | 1971-10-06 | 1976-12-08 | ||
US4100269A (en) | 1973-06-28 | 1978-07-11 | Lever Brothers Company | Anticalculus dentifrice |
US4022880A (en) | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
US4082841A (en) | 1975-10-10 | 1978-04-04 | Lever Brothers Company | Dentifrice |
US4144323A (en) | 1978-06-15 | 1979-03-13 | Lever Brothers Company | Novel anticalculus compositions |
JPS5846483B2 (en) | 1979-09-20 | 1983-10-17 | ライオン株式会社 | Oral composition |
DE3069906D1 (en) | 1979-10-02 | 1985-02-14 | Gaba International Ag | Oral compositions with stabilised zinc salts |
EP0152836B1 (en) * | 1984-02-20 | 1990-06-20 | Blendax GmbH | Oral hygiene composition |
NZ214031A (en) | 1984-12-11 | 1989-05-29 | Colgate Palmolive Co | Astringent dentifrice containing synthetic, precipitated, amorphous silica gel as polishing agent |
US5288480A (en) | 1987-01-30 | 1994-02-22 | Colgate-Palmolive Co. | Antiplaque antibacterial oral composition |
US4839157A (en) | 1987-04-17 | 1989-06-13 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel containing fumed silicas |
US5188820A (en) * | 1989-10-05 | 1993-02-23 | Chesebrough-Pond's Usa Co., Dividion Of Conopco, Inc. | Method of inhibiting plaque on teeth by applying an oral composition |
GB8922434D0 (en) | 1989-10-05 | 1989-11-22 | Unilever Plc | Oral compositions |
GB8922594D0 (en) * | 1989-10-06 | 1989-11-22 | Unilever Plc | Oral compositions |
US5256396A (en) * | 1990-01-24 | 1993-10-26 | Colgate-Palmolive Company | Topical composition |
JPH05930A (en) * | 1991-06-25 | 1993-01-08 | Lion Corp | Composition for oral cavity |
US5240697A (en) * | 1991-10-17 | 1993-08-31 | Colgate-Palmolive Company | Desensitizing anti-tartar dentifrice |
US5695746A (en) | 1995-07-28 | 1997-12-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Liquid dentifrice with mouthwash fresh taste |
US5603922A (en) | 1995-08-08 | 1997-02-18 | Enamelon Inc. | Processes and compositions for the remineralization of teeth |
US6036944A (en) | 1995-08-08 | 2000-03-14 | Enamelon, Inc. | Processes for the remineralization and mineralization of teeth |
NZ335780A (en) | 1996-10-23 | 2001-01-26 | Univ New York State Res Found | Compositions to control oral microbial oxidation-reduction (Eh) levels and treat gingivitis-periodontitis |
JPH11228368A (en) | 1998-02-18 | 1999-08-24 | Sunstar Inc | Composition for oral cavity |
JPH11246375A (en) | 1998-02-27 | 1999-09-14 | Sunstar Inc | Composition for oral cavity |
US5858333A (en) | 1998-08-07 | 1999-01-12 | Enamelon, Inc. | Two-part oral products and methods of using same to remineralize teeth |
US6169118B1 (en) * | 1998-11-12 | 2001-01-02 | Block Drug Company, Inc. | Flavor blend for masking unpleasant taste of zinc compounds |
CN101330900A (en) * | 2005-12-20 | 2008-12-24 | 宝洁公司 | Oral care compositions comprising zinc and phytate |
US20110229534A1 (en) * | 2006-10-05 | 2011-09-22 | The Trustees Of Columbia University In The City Of New York | Non-Irritating Oral Care Formulations |
US20080138298A1 (en) * | 2006-12-12 | 2008-06-12 | The Procter & Gamble Company | Oral care compositions comprising zinc and phytate |
US8865137B2 (en) * | 2009-05-26 | 2014-10-21 | Colgate-Palmolive Company | Dentifrice composition |
JP2012532141A (en) * | 2009-06-30 | 2012-12-13 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | Antimicrobial / preservative composition containing plant components |
-
2010
- 2010-12-21 CN CN201080070856.6A patent/CN103260591B/en active Active
- 2010-12-21 JP JP2013546086A patent/JP5947810B2/en not_active Expired - Fee Related
- 2010-12-21 CA CA2822025A patent/CA2822025C/en active Active
- 2010-12-21 MX MX2013007226A patent/MX343586B/en active IP Right Grant
- 2010-12-21 RU RU2013133680/15A patent/RU2560687C2/en active
- 2010-12-21 AU AU2010365811A patent/AU2010365811B2/en active Active
- 2010-12-21 BR BR112013015972-3A patent/BR112013015972B1/en active IP Right Grant
- 2010-12-21 SG SG2013040936A patent/SG190904A1/en unknown
- 2010-12-21 WO PCT/US2010/061414 patent/WO2012087288A2/en active Application Filing
- 2010-12-21 MY MYPI2013002380A patent/MY162655A/en unknown
- 2010-12-21 EP EP10816360.1A patent/EP2654684B1/en active Active
- 2010-12-21 US US13/996,036 patent/US9486396B2/en active Active
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- 2011-12-20 TW TW100147339A patent/TWI461202B/en not_active IP Right Cessation
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TW201231056A (en) | 2012-08-01 |
WO2012087288A3 (en) | 2012-12-27 |
SG190904A1 (en) | 2013-07-31 |
RU2013133680A (en) | 2015-01-27 |
RU2560687C2 (en) | 2015-08-20 |
US20170020795A1 (en) | 2017-01-26 |
JP5947810B2 (en) | 2016-07-06 |
WO2012087288A2 (en) | 2012-06-28 |
MX343586B (en) | 2016-11-10 |
MX2013007226A (en) | 2013-08-15 |
AU2010365811B2 (en) | 2016-02-11 |
CN103260591B (en) | 2016-10-26 |
CN103260591A (en) | 2013-08-21 |
BR112013015972B1 (en) | 2018-12-04 |
US20130287709A1 (en) | 2013-10-31 |
BR112013015972A2 (en) | 2018-07-10 |
MY162655A (en) | 2017-06-30 |
AU2010365811A1 (en) | 2013-05-09 |
EP2654684B1 (en) | 2017-06-07 |
CA2822025A1 (en) | 2012-06-28 |
TWI461202B (en) | 2014-11-21 |
US9486396B2 (en) | 2016-11-08 |
EP2654684A2 (en) | 2013-10-30 |
JP2014507399A (en) | 2014-03-27 |
AR084445A1 (en) | 2013-05-15 |
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