CA2759015A1 - Stents having controlled elution - Google Patents
Stents having controlled elution Download PDFInfo
- Publication number
- CA2759015A1 CA2759015A1 CA2759015A CA2759015A CA2759015A1 CA 2759015 A1 CA2759015 A1 CA 2759015A1 CA 2759015 A CA2759015 A CA 2759015A CA 2759015 A CA2759015 A CA 2759015A CA 2759015 A1 CA2759015 A1 CA 2759015A1
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- Prior art keywords
- rapamycin
- active agent
- ethyl
- coating
- stent
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- 0 CC(*)C(*)C(C(I)ICO)N Chemical compound CC(*)C(*)C(C(I)ICO)N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/63—Crystals
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Abstract
Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device;
wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
Claims (54)
1. A device comprising a. a stent; and b. a coating on the stent; wherein the coating comprises at least one bioabsorbable polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the coating opposite the stent and wherein 50% or less of the total amount of active agent in the coating is released after 24 hours in vitro elution.
2. The device of Claim 1, wherein in vitro elution is carried out in a 1:1 spectroscopic grade ethanol/phosphate buffer saline at pH 7.4 and 37°C; wherein the amount of active agent released is determined by measuring UV absorption.
3. The device of Claim 2 wherein UV absorption is detected at 278 nm by a diode array spectrometer.
4. The device of Claim 1, wherein presence of active agent on at least a region of the surface of the coating is determined by cluster secondary ion mass spectrometry (cluster SIMS).
5. The device of Claim 1, wherein presence of active agent on at least a region of the surface of the coating is determined by generating cluster secondary ion mass spectrometry (cluster SIMS) depth profiles.
6. The device of Claim 1, wherein presence of active agent on at least a region of the surface of the coating is determined by time of flight secondary ion mass spectrometry (TOF-SIMS).
7. The device of Claim 1, wherein presence of active agent on at least a region of the surface of the coating is determined by atomic force microscopy (AFM).
8. The device of Claim 1, wherein presence of active agent on at least a region of the surface of the coating is determined by X-ray spectroscopy.
9. The device of Claim 1, wherein presence of active agent on at least a region of the surface of the coating is determined by electronic microscopy.
10. The device of Claim 1, wherein presence of active agent on at least a region of the surface of the coating is determined by Raman spectroscopy.
11. The device of Claim 1, wherein between 25% and 45% of the total amount of active agent in the coating is released after 24 hours in vitro elution in a 1:1 spectroscopic grade ethanol/phosphate buffer saline at pH 7.4 and 37°C; wherein the amount of the active agent released is determined by measuring UV absorption at 278 nm by a diode array spectrometer.
12. The device of Claim 1, wherein the active agent is at least 50%
crystalline.
crystalline.
13. The device of Claim 1, wherein the active agent is at least 75%
crystalline.
crystalline.
14. The device of Claim 1, wherein the active agent is at least 90%
crystalline.
crystalline.
15. The device of Claim 1, wherein the polymer comprises a PLGA copolymer.
16. The device of Claim 1, wherein the coating comprises a first PLGA
copolymer with a ratio of about 40:60 to about 60:40 and a second PLGA copolymer with a ratio of about 60:40 to about 90:10.
copolymer with a ratio of about 40:60 to about 60:40 and a second PLGA copolymer with a ratio of about 60:40 to about 90:10.
17. The device of Claim 1, wherein the coating comprises a first PLGA
copolymer having a molecular weight of about 10kD and a second polymer is a PLGA copolymer having a molecular weight of about 19kD.
copolymer having a molecular weight of about 10kD and a second polymer is a PLGA copolymer having a molecular weight of about 19kD.
18. The device of Claim 1, wherein the bioabsorbable polymer is selected from the group PLGA, PGA poly(glycolide), LPLA poly(1-lactide), DLPLA poly(dl-lactide), PCL poly(e-caprolactone) PDO, poly(dioxolane) PGA-TMC, 85/15 DLPLG p(dl-lactide-co-glycolide), 75/25 DLPL, 65/35 DLPLG, 50/50 DLPLG, TMC poly(trimethylcarbonate), p(CPP:SA) poly(1,3-bis-p-(carboxyphenoxy)propane-co-sebacic acid).
19. The device of Claim 1, wherein the stent is formed of stainless steel material.
20. The device of Claim 1, wherein the stent is formed of a material comprising a cobalt chromium alloy.
21. The device of Claim 1, wherein the stent is formed from a material comprising the following percentages by weight: about 0.05 to about0.15 C, about 1.00 to about2.00 Mn, about 0.04 Si, about 0.03 P, about 0.3 S, about 19.0 to about 21.0 Cr, about 9.0 to about 11.0 Ni, about 14.0 to about 16.00 W, about 3.0 Fe, and Bal. Co.
22. The device of Claim 1, wherein the stent is formed from a material comprising at most the following percentages by weight: about 0.025 C, about 0.15 Mn, aboout 0.15 Si, about 0.015 P, about 0.01 S, about 19.0 to about 21.0 Cr, about 33 to about 37 Ni, about 9.0 to about 10.5 Mo, about 1.0 Fe, about 1.0 Ti, and Bal. Co.
23. The device of Claim 1, wherein the stent is formed from a material comprising L605 alloy.
24. The device of Claim 1, wherein the stent has a thickness of from about 50%
to about 90% of a total thickness of the device.
to about 90% of a total thickness of the device.
25. The device of Claim 1, wherein the device has a thickness of from about 20 µm to about 500 µm.
26. The device of Claim 1, wherein the stent has a thickness of from about 50 µm to about 80 µm.
27. The device of Claim 1, wherein the coating has a total thickness of from about 5 µm to about 50 µm.
28. The device of Claim 1, wherein the device has an active agent content of from about 5 µg to about 500 µg.
29. The device of Claim 1, wherein the device has an active agent content of from about 100 µg to about 160 µg.
30. The device of Claim 1, wherein the active agent is selected from rapamycin, a prodrug, a derivative, an analog, a hydrate, an ester, and a salt thereof.
31. The device of Claim 1, wherein the active agent is selected from one or more of sirolimus, everolimus, zotarolimus and biolimus.
32. The device of Claim 1, wherein the active agent comprises a macrolide immunosuppressive (limus) drug.
33. The device of Claim 32, wherein the macrolide immunosuppressive drug comprises one or more of rapamycin, biolimus (biolimus A9), 40-O-(2-Hydroxyethyl)rapamycin (everolimus), 40-O-Benzyl-rapamycin, 40-O-(4'-Hydroxymethyl)benzyl-rapamycin, 40-O-[4'-(1,2-Dihydroxyethyl)]benzyl-rapamycin, 40-O-Allyl-rapamycin, 40-O-[3'-(2,2-Dimethyl-1,3-dioxolan-4(S)-yl)-prop-2'-en-1'-yl]-rapamycin, (2':E,4'S)-40-O-(4',5'-Dihydroxypent-2'-en-1'-yl)-rapamycin 40-O-(2-Hydroxy)ethoxycar-bonylmethyl-rapamycin, 40-O-(3-Hydroxy)propyl-rapamycin 40-O-(6-Hydroxy)hexyl-rapamycin 40-O-[2-(2-Hydroxy)ethoxy]ethyl-rapamycin 40-O-[(3S)-2,2-Dimethyldioxolan- 3 -yl] methyl-rapamycin, 40-O-[(2S)-2,3-Dihydroxyprop-1-yl]-rapamycin, 40-O-(2-Acetoxy)ethyl-rapamycin 40-O-(2-Nicotinoyloxy)ethyl-rapamycin, 40-O-[2-(N-Morpholino)acetoxy]ethyl-rapamycin 40-O-(2-N-Imidazolylacetoxy)ethyl-rapamycin, 40-O-[2-(N-Methyl-N'-piperazinyl)acetoxy]ethyl-rapamycin, 39-O-Desmethyl-39,40-O,O-ethylene-rapamycin, (26R)-26-Dihydro-40-O-(2-hydroxy)ethyl-rapamycin, 28-O-Methyl-rapamycin, 40-O-(2-Aminoethyl)-rapamycin, 40-O-(2-Acetaminoethyl)-rapamycin 40-O-(2-Nicotinamidoethyl)-rapamycin, 40-O-(2-(N-Methyl-imidazo-2'-ylcarbethoxamido)ethyl)-rapamycin, 40-O-(2-Ethoxycarbonylaminoethyl)-rapamycin, 40-O-(2-Tolylsulfonamidoethyl)-rapamycin, 40-O-[2-(4',5'-Dicarboethoxy-1',2',3'-triazol-1'-yl)-ethyl]-rapamycin, 42-Epi-(tetrazolyl)rapamycin (tacrolimus), 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin (temsirolimus), (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)-rapamycin (zotarolimus), and salts, derivatives, isomers, racemates, diastereoisomers, prodrugs, hydrate, ester, or analogs thereof.
34. A device comprising a. a stent; and b. a coating on the stent; wherein the coating comprises at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the coating opposite the stent and wherein between about 5% to about 25% of the total amount of active agent is eluted one day after the device is contacted within in vitro elution media.
35. The device of Claim 34, wherein the polymer comprises is at least one of.
a fluoropolymer, PVDF-HFP comprising vinylidene fluoride and hexafluoropropylene monomers, PC
(phosphorylcholine), Polysulfone, polystyrene-b-isobutylene-b-styrene, PVP
(polyvinylpyrrolidone), alkyl methacrylate, vinyl acetate, hydroxyalkyl methacrylate, and alkyl acrylate.
a fluoropolymer, PVDF-HFP comprising vinylidene fluoride and hexafluoropropylene monomers, PC
(phosphorylcholine), Polysulfone, polystyrene-b-isobutylene-b-styrene, PVP
(polyvinylpyrrolidone), alkyl methacrylate, vinyl acetate, hydroxyalkyl methacrylate, and alkyl acrylate.
36. The device of Claim 35, wherein the alkyl methacrylate comprises at least one of methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, hexyl methacrylate, octyl methacrylate, dodecyl methacrylate, and lauryl methacrylate; and wherein the alkyl acrylate comprises at least one of methyl acrylate, ethyl acrylate, propyl acrylate, butyl acrylate, hexyl acrylate, octyl acrylate, dodecyl acrylates, and lauryl acrylate.
37. The device of Claim 34, wherein the polymer is not a polymer selected from: PBMA (poly n-butyl methacrylate), Parylene C, and polyethylene-co-vinyl acetate.
38. The device of Claim 34, wherein the polymer comprises a durable polymer.
39. The device of Claim 34, wherein the polymer comprises a bioabsorbable polymer.
40. The device of Claim 39, wherein the bioabsorbable polymer is selected from the group PLGA, PGA poly(glycolide), LPLA poly(1-lactide), DLPLA poly(dl-lactide), PCL poly(e-caprolactone) PDO, poly(dioxolane) PGA-TMC, 85/15 DLPLG p(dl-lactide-co-glycolide), 75/25 DLPL, 65/35 DLPLG, 50/50 DLPLG, TMC poly(trimethylcarbonate), p(CPP:SA) poly(1,3-bis-p-(carboxyphenoxy)propane-co-sebacic acid).
41. The device of Claim 34, wherein in vitro elution is carried out in a 1:1 spectroscopic grade ethanol/phosphate buffer saline at pH 7.4 and 37°C; wherein the amount of active agent released is determined by measuring UV absorption.
42. The device of Claim 34, wherein the active agent is at least 50%
crystalline.
crystalline.
43. The device of Claim 34, wherein the active agent is at least 75%
crystalline.
crystalline.
44. The device of Claim 34, wherein the active agent is at least 90%
crystalline.
crystalline.
45. The device of Claim 34, wherein the stent is formed of at least one of stainless steel material and a cobalt chromium alloy.
46. The device of Claim 34, wherein the stent has a thickness of from about 50% to about 90% of a total thickness of the device.
47. The device of Claim 34, wherein the device has a thickness of from about 20 µm to about 500 µm.
48. The device of Claim 34, wherein the stent has a thickness of from about 50 µm to about 80 µm.
49. The device of Claim 34, wherein the coating has a total thickness of from about 5 µm to about 50 µm.
50. The device of Claim 34, wherein the device has an active agent content of from about 5 gg to about 500 µg.
51. The device of Claim 34, wherein the device has an active agent content of from about 100 µg to about 160 µg.
52. The device of Claim 34, wherein the active agent is selected from rapamycin, a prodrug, a derivative, an analog, a hydrate, an ester, and a salt thereof.
53. The device of Claim 34, wherein the active agent comprises a macrolide immunosuppressive (limus) drug.
54. The device of Claim 53, wherein the macrolide immunosuppressive drug comprises one or more of rapamycin, biolimus (biolimus A9), 40-O-(2-Hydroxyethyl)rapamycin (everolimus), 40-O-Benzyl-rapamycin, 40-O-(4'-Hydroxymethyl)benzyl-rapamycin, 40-O-[4'-(1,2-Dihydroxyethyl)]benzyl-rapamycin, 40-O-Allyl-rapamycin, 40-O-[3'-(2,2-Dimethyl-1,3-dioxolan-4(S)-yl)-prop-2'-en-1'-yl]-rapamycin, (2':E,4'S)-40-O-(4',5'-Dihydroxypent-2'-en-1'-yl)-rapamycin 40-O-(2-Hydroxy)ethoxycar-bonylmethyl-rapamycin, 40-O-(3-Hydroxy)propyl-rapamycin 40-O-(6-Hydroxy)hexyl-rapamycin 40-O-[2-(2-Hydroxy)ethoxy]ethyl-rapamycin 40-O-[(3S)-2,2-Dimethyldioxolan-3-yl]methyl-rapamycin, 40-O-[(2S)-2,3-Dihydroxyprop-1-yl]-rapamycin, 40-O-(2-Acetoxy)ethyl-rapamycin 40-O-(2-Nicotinoyloxy)ethyl-rapamycin, 40-O-[2-(N-Morpholino)acetoxy]ethyl-rapamycin 40-O-(2-N-Imidazolylacetoxy)ethyl-rapamycin, 40-O-[2-(N-Methyl-N'-piperazinyl)acetoxy]ethyl-rapamycin, 39-O-Desmethyl-39,40-O,O-ethylene-rapamycin, (26R)-26-Dihydro-40-O-(2-hydroxy)ethyl-rapamycin, 28-O-Methyl-rapamycin, 40-O-(2-Aminoethyl)-rapamycin, 40-O-(2-Acetaminoethyl)-rapamycin 40-O-(2-Nicotinamidoethyl)-rapamycin, 40-O-(2-(N-Methyl-imidazo-2'-ylcarbethoxamido)ethyl)-rapamycin, 40-O-(2-Ethoxycarbonylaminoethyl)-rapamycin, 40-O-(2-Tolylsulfonamidoethyl)-rapamycin, 40-O-[2-(4',5'-Dicarboethoxy-1',2',3'-triazol-1'-yl)-ethyl]-rapamycin, 42-Epi-(tetrazolyl)rapamycin (tacrolimus), 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin (temsirolimus), (42S)-42-Deoxy-42-(1H-tetrazol- 1-yl)-rapamycin (zotarolimus), and salts, derivatives, isomers, racemates, diastereoisomers, prodrugs, hydrate, ester, or analogs thereof.
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Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090062909A1 (en) | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
CA2615452C (en) | 2005-07-15 | 2015-03-31 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
CA2996768C (en) | 2006-04-26 | 2020-12-08 | Micell Technologies, Inc. | Coatings containing multiple drugs |
WO2008042909A2 (en) | 2006-10-02 | 2008-04-10 | Micell Technologies Inc. | Surgical sutures having increased strength |
CA2667228C (en) | 2006-10-23 | 2015-07-14 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
CA2679712C (en) | 2007-01-08 | 2016-11-15 | Micell Technologies, Inc. | Stents having biodegradable layers |
RU2447901C2 (en) | 2007-01-21 | 2012-04-20 | Хемотек Аг | Medical device for treating lumen obturations and preventing threatening recurrent obturations |
AU2008256684B2 (en) | 2007-05-25 | 2012-06-14 | Micell Technologies, Inc. | Polymer films for medical device coating |
US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
US20170360609A9 (en) | 2007-09-24 | 2017-12-21 | Ivantis, Inc. | Methods and devices for increasing aqueous humor outflow |
US8425449B2 (en) | 2009-07-09 | 2013-04-23 | Ivantis, Inc. | Ocular implants and methods for delivering ocular implants into the eye |
CA2717441A1 (en) | 2008-03-05 | 2009-09-11 | Ivantis, Inc. | Methods and apparatus for treating glaucoma |
EP2271294B1 (en) | 2008-04-17 | 2018-03-28 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
JP2011528275A (en) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | Drug delivery medical device |
US9119906B2 (en) * | 2008-09-24 | 2015-09-01 | Integran Technologies, Inc. | In-vivo biodegradable medical implant |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
CN102481195B (en) | 2009-04-01 | 2015-03-25 | 米歇尔技术公司 | Drug delivery medical device |
WO2010121187A2 (en) * | 2009-04-17 | 2010-10-21 | Micell Techologies, Inc. | Stents having controlled elution |
AU2010271274B2 (en) | 2009-07-09 | 2015-05-21 | Alcon Inc. | Single operator device for delivering an ocular implant |
EP3064230B1 (en) | 2009-07-10 | 2019-04-10 | Boston Scientific Scimed, Inc. | Use of nanocrystals for a drug delivery balloon |
EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | Drug delivery medical device |
EP2453938B1 (en) | 2009-07-17 | 2015-08-19 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
US11369498B2 (en) | 2010-02-02 | 2022-06-28 | MT Acquisition Holdings LLC | Stent and stent delivery system with improved deliverability |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
WO2011130448A1 (en) * | 2010-04-16 | 2011-10-20 | Micell Technologies, Inc. | Stents having controlled elution |
WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
EP2611476B1 (en) | 2010-09-02 | 2016-08-10 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
WO2012034079A2 (en) | 2010-09-09 | 2012-03-15 | Micell Technologies, Inc. | Macrolide dosage forms |
EP2696815B1 (en) * | 2011-04-13 | 2019-03-20 | Micell Technologies, Inc. | Stents having controlled elution |
WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US8657776B2 (en) | 2011-06-14 | 2014-02-25 | Ivantis, Inc. | Ocular implants for delivery into the eye |
CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
CN102552992B (en) * | 2011-09-22 | 2014-06-11 | 上海微特生物技术有限公司 | Multilayered composite tube, manufacturing method thereof, and application thereof |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
US8663150B2 (en) | 2011-12-19 | 2014-03-04 | Ivantis, Inc. | Delivering ocular implants into the eye |
US9358156B2 (en) | 2012-04-18 | 2016-06-07 | Invantis, Inc. | Ocular implants for delivery into an anterior chamber of the eye |
US10617558B2 (en) | 2012-11-28 | 2020-04-14 | Ivantis, Inc. | Apparatus for delivering ocular implants into an anterior chamber of the eye |
KR20150143476A (en) | 2013-03-12 | 2015-12-23 | 미셀 테크놀로지즈, 인코포레이티드 | Bioabsorbable biomedical implants |
KR102079613B1 (en) | 2013-05-15 | 2020-02-20 | 미셀 테크놀로지즈, 인코포레이티드 | Bioabsorbable biomedical implants |
US11839698B2 (en) | 2014-03-13 | 2023-12-12 | W. L. Gore & Associates, Inc. | Drug composition and coating |
WO2016011056A1 (en) | 2014-07-14 | 2016-01-21 | Ivantis, Inc. | Ocular implant delivery system and method |
US11406742B2 (en) | 2014-07-18 | 2022-08-09 | M.A. Med Alliance SA | Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs |
US9730819B2 (en) * | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
CN108135470B (en) | 2015-08-14 | 2021-03-09 | 伊万提斯公司 | Ocular implant with pressure sensor and delivery system |
JP6823875B2 (en) | 2015-09-15 | 2021-02-03 | サベージ メディカル, インコーポレイテッド | Devices and methods for mooring sheaths in tissue cavities |
WO2017106517A1 (en) | 2015-12-15 | 2017-06-22 | Ivantis, Inc. | Ocular implant and delivery system |
CN108883211B (en) * | 2016-05-04 | 2021-09-24 | 北京阿迈特医疗器械有限公司 | Modified biodegradable medical polymer devices and methods of making the same |
KR101653535B1 (en) | 2016-05-31 | 2016-09-05 | 전남대학교병원 | Polymer-Free Everolimus-Eluting Coronary Stent Fabricated by Electrospinning Technique |
IL265511B (en) * | 2016-12-22 | 2022-07-01 | Sino Medical Sciences Tech Inc | Drug eluting stent and method of use of the same for enabling restoration of functional endothelial cell layers |
US10201639B2 (en) * | 2017-05-01 | 2019-02-12 | 480 Biomedical, Inc. | Drug-eluting medical implants |
EP3635384A4 (en) * | 2017-09-14 | 2021-01-20 | Hewlett-Packard Development Company, L.P. | Chromatography surface enhanced luminescence (sel) sensing |
JP2024503989A (en) | 2021-01-11 | 2024-01-30 | アルコン インコーポレイティド | Systems and methods for viscoelastic delivery |
WO2023160630A1 (en) * | 2022-02-23 | 2023-08-31 | Sino Medical Sciences Technology Inc. | Method for preparing drug eluting balloons without coating |
CN115232265B (en) * | 2022-07-28 | 2023-09-05 | 哈尔滨工业大学 | Triple shape memory hydrogel and preparation method thereof |
Family Cites Families (556)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3123077A (en) | 1964-03-03 | Surgical suture | ||
US3087860A (en) | 1958-12-19 | 1963-04-30 | Abbott Lab | Method of prolonging release of drug from a precompressed solid carrier |
US3087660A (en) | 1962-07-24 | 1963-04-30 | Yankee Plasties Inc | Two-step garment hanger |
US3457280A (en) | 1967-06-12 | 1969-07-22 | American Cyanamid Co | Alpha-glycolide and methods for the isolation thereof |
US3597449A (en) | 1967-11-16 | 1971-08-03 | American Cyanamid Co | Stable glycolide and lactide composition |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE2010115A1 (en) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Process for the production of micro-granules |
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US4000137A (en) | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
US4188373A (en) | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
US4285987A (en) | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
JPS5668674A (en) | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
US4326532A (en) | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
US4474572A (en) | 1981-09-29 | 1984-10-02 | Syntex (U.S.A.) Inc. | Implanting device and implant magazine |
SE445884B (en) | 1982-04-30 | 1986-07-28 | Medinvent Sa | DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
SE435444B (en) | 1983-02-25 | 1984-10-01 | Hakan Johansson | Fishing gear with a fishing line made by a light guide |
US4606347A (en) | 1983-03-25 | 1986-08-19 | Thomas J. Fogarty | Inverted balloon catheter having sealed through lumen |
US4478822A (en) | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
US4474751A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
US4582731A (en) | 1983-09-01 | 1986-04-15 | Battelle Memorial Institute | Supercritical fluid molecular spray film deposition and powder formation |
US4734227A (en) | 1983-09-01 | 1988-03-29 | Battelle Memorial Institute | Method of making supercritical fluid molecular spray films, powder and fibers |
US4734451A (en) | 1983-09-01 | 1988-03-29 | Battelle Memorial Institute | Supercritical fluid molecular spray thin films and fine powders |
US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
JPH0698902B2 (en) | 1986-01-30 | 1994-12-07 | マツダ株式会社 | Vehicle transmission torque control device |
US4985625A (en) | 1986-03-06 | 1991-01-15 | Finnigan Corporation | Transfer line for mass spectrometer apparatus |
US4762593A (en) | 1986-06-13 | 1988-08-09 | Youngner Philip G | Distilling apparatus |
US4758435A (en) | 1986-08-11 | 1988-07-19 | American Cyanamid Company | Estradiol implant composition and method for preparation |
US5106650A (en) | 1988-07-14 | 1992-04-21 | Union Carbide Chemicals & Plastics Technology Corporation | Electrostatic liquid spray application of coating with supercritical fluids as diluents and spraying from an orifice |
US4950239A (en) | 1988-08-09 | 1990-08-21 | Worldwide Medical Plastics Inc. | Angioplasty balloons and balloon catheters |
DE68922497T2 (en) | 1988-08-24 | 1995-09-14 | Marvin J Slepian | ENDOLUMINAL SEAL WITH BISDEGRADABLE POLYMERS. |
US4931037A (en) | 1988-10-13 | 1990-06-05 | International Medical, Inc. | In-dwelling ureteral stent and injection stent assembly, and method of using same |
US4958625A (en) | 1989-07-18 | 1990-09-25 | Boston Scientific Corporation | Biopsy needle instrument |
DE69002295T2 (en) | 1989-09-25 | 1993-11-04 | Schneider Usa Inc | MULTILAYER EXTRUSION AS A METHOD FOR PRODUCING BALLOONS FOR VESSEL PLASTICS. |
CA2026604A1 (en) | 1989-10-02 | 1991-04-03 | Rodney G. Wolff | Articulated stent |
US5000519A (en) | 1989-11-24 | 1991-03-19 | John Moore | Towed vehicle emergency brake control system |
US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
JP2641781B2 (en) | 1990-02-23 | 1997-08-20 | シャープ株式会社 | Method of forming semiconductor element isolation region |
US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5360403A (en) | 1990-05-16 | 1994-11-01 | Lake Region Manufacturing Co., Inc. | Balloon catheter with lumen occluder |
AU7998091A (en) | 1990-05-17 | 1991-12-10 | Harbor Medical Devices, Inc. | Medical device polymer |
US5320634A (en) | 1990-07-03 | 1994-06-14 | Interventional Technologies, Inc. | Balloon catheter with seated cutting edges |
US5090419A (en) | 1990-08-23 | 1992-02-25 | Aubrey Palestrant | Apparatus for acquiring soft tissue biopsy specimens |
US6248129B1 (en) | 1990-09-14 | 2001-06-19 | Quanam Medical Corporation | Expandable polymeric stent with memory and delivery apparatus and method |
US6524698B1 (en) | 1990-09-27 | 2003-02-25 | Helmuth Schmoock | Fluid impermeable foil |
GB2253164B (en) | 1991-02-22 | 1994-10-05 | Hoechst Uk Ltd | Improvements in or relating to electrostatic coating of substrates of medicinal products |
US5158986A (en) | 1991-04-05 | 1992-10-27 | Massachusetts Institute Of Technology | Microcellular thermoplastic foamed with supercritical fluid |
US5195969A (en) | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5372676A (en) | 1991-05-15 | 1994-12-13 | Lowe; Michael | Method for producing replicated paving stone |
US5185776A (en) | 1991-08-05 | 1993-02-09 | Townsend Boyd E | Cover for an x-ray cassette |
US5356433A (en) | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
US5243023A (en) | 1991-08-28 | 1993-09-07 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Polyimides containing amide and perfluoroisopropylidene connecting groups |
US5366504A (en) | 1992-05-20 | 1994-11-22 | Boston Scientific Corporation | Tubular medical prosthesis |
JPH0698902A (en) | 1991-11-22 | 1994-04-12 | Janome Sewing Mach Co Ltd | Production of bone implant |
US5125570A (en) | 1991-12-30 | 1992-06-30 | Robert Jones | Delivery box signal device |
US5697882A (en) | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | System and method for electrosurgical cutting and ablation |
JPH07505316A (en) | 1992-03-31 | 1995-06-15 | ボストン サイエンティフィック コーポレーション | medical wire |
US5288711A (en) | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
US5342621A (en) | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
US5500180A (en) | 1992-09-30 | 1996-03-19 | C. R. Bard, Inc. | Method of making a distensible dilatation balloon using a block copolymer |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5387313A (en) | 1992-11-09 | 1995-02-07 | Bmc Industries, Inc. | Etchant control system |
US5385776A (en) | 1992-11-16 | 1995-01-31 | Alliedsignal Inc. | Nanocomposites of gamma phase polymers containing inorganic particulate material |
EP0604022A1 (en) | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method for its manufacture |
US5324049A (en) | 1992-12-23 | 1994-06-28 | Xerox Corporation | Mandrel with flared, dish shaped disk and process for using mandrel |
ES2166370T3 (en) | 1993-01-19 | 2002-04-16 | Schneider Usa Inc | IMPLANTABLE FILAMENT IN COMPOSITE MATERIAL. |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5340614A (en) | 1993-02-11 | 1994-08-23 | Minnesota Mining And Manufacturing Company | Methods of polymer impregnation |
US6228879B1 (en) | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5578709A (en) | 1993-03-09 | 1996-11-26 | Middlesex Sciences, Inc. | Macromolecular microparticles and methods of production |
WO1994021308A1 (en) | 1993-03-18 | 1994-09-29 | Cedars-Sinai Medical Center | Drug incorporating and releasing polymeric coating for bioprosthesis |
US20020055710A1 (en) | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
US5403347A (en) | 1993-05-27 | 1995-04-04 | United States Surgical Corporation | Absorbable block copolymers and surgical articles fabricated therefrom |
US5350627A (en) | 1993-06-11 | 1994-09-27 | Camelot Technologies, Inc. | Coated webs |
US5380299A (en) | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
DE4336209C2 (en) | 1993-09-10 | 1995-09-21 | Michael Dr Simon | Method for producing a vascular prosthesis coated with antithrombotic agents |
US5632772A (en) | 1993-10-21 | 1997-05-27 | Corvita Corporation | Expandable supportive branched endoluminal grafts |
US5350361A (en) | 1993-11-10 | 1994-09-27 | Medtronic, Inc. | Tri-fold balloon for dilatation catheter and related method |
US5494620A (en) | 1993-11-24 | 1996-02-27 | United States Surgical Corporation | Method of manufacturing a monofilament suture |
US5626611A (en) | 1994-02-10 | 1997-05-06 | United States Surgical Corporation | Composite bioabsorbable materials and surgical articles made therefrom |
US6146356A (en) | 1994-03-02 | 2000-11-14 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
ES2141928T5 (en) | 1994-03-02 | 2009-04-16 | Boston Scientific Limited | BALLS OF ELASTOMERO COPOLIMERO IN BLOCKS FOR CATHETER. |
US5843120A (en) | 1994-03-17 | 1998-12-01 | Medinol Ltd. | Flexible-expandable stent |
US5733303A (en) | 1994-03-17 | 1998-03-31 | Medinol Ltd. | Flexible expandable stent |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
WO1996000081A1 (en) | 1994-06-24 | 1996-01-04 | Immunex Corporation | Controlled release polypeptide compositions and methods of treating inflammatory bowel disease |
EP0771339B1 (en) | 1994-07-12 | 2003-10-15 | BPSI Holdings, Inc. | Dry moisture barrier film coating composition, method of coating substrates using the same and pharmaceutical tablets coated therewith |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
NL9401690A (en) | 1994-10-13 | 1996-05-01 | Industrial Res Bv | Body-implantable stent. |
AU704888B2 (en) | 1994-12-02 | 1999-05-06 | Science Incorporated | Medicament dispenser |
JPH10511957A (en) | 1995-01-05 | 1998-11-17 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ ミシガン | Surface-modified nanoparticles and methods for their production and use |
US5599576A (en) | 1995-02-06 | 1997-02-04 | Surface Solutions Laboratories, Inc. | Medical apparatus with scratch-resistant coating and method of making same |
US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US20020091433A1 (en) | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
DE29624503U1 (en) | 1995-04-19 | 2004-09-16 | Boston Scientific Scimed, Inc. | Drug-releasing coated stent |
US5570537A (en) | 1995-04-27 | 1996-11-05 | Black; Douglas A. | Electronic insecticidal cable |
DE69625822T2 (en) | 1995-05-01 | 2003-06-05 | Samyang Corp | IMPLANTABLE, BIORESORBABLE MEMBRANE AND METHOD FOR THE PRODUCTION THEREOF |
US6602281B1 (en) | 1995-06-05 | 2003-08-05 | Avantec Vascular Corporation | Radially expansible vessel scaffold having beams and expansion joints |
US5674242A (en) | 1995-06-06 | 1997-10-07 | Quanam Medical Corporation | Endoprosthetic device with therapeutic compound |
US5714007A (en) | 1995-06-06 | 1998-02-03 | David Sarnoff Research Center, Inc. | Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
DE69624921T2 (en) | 1995-06-09 | 2003-09-11 | Novartis Ag | rapamycin derivatives |
US6256529B1 (en) | 1995-07-26 | 2001-07-03 | Burdette Medical Systems, Inc. | Virtual reality 3D visualization for surgical procedures |
JP3476604B2 (en) | 1995-08-22 | 2003-12-10 | 鐘淵化学工業株式会社 | Method for manufacturing stent with drug attached / coated |
DE69600289T2 (en) | 1995-09-19 | 1998-09-03 | Mitsubishi Gas Chemical Co | Biodegradable water-soluble polymer |
US5607442A (en) | 1995-11-13 | 1997-03-04 | Isostent, Inc. | Stent with improved radiopacity and appearance characteristics |
CA2192520A1 (en) | 1996-03-05 | 1997-09-05 | Ian M. Penn | Expandable stent and method for delivery of same |
US6461644B1 (en) | 1996-03-25 | 2002-10-08 | Richard R. Jackson | Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods |
NZ331269A (en) | 1996-04-10 | 2000-01-28 | Advanced Cardiovascular System | Expandable stent, its structural strength varying along its length |
US5669932A (en) | 1996-05-29 | 1997-09-23 | Isostent, Inc. | Means for accurately positioning an expandable stent |
ATE443117T1 (en) | 1996-05-31 | 2009-10-15 | Toto Ltd | ANTIFOULING ELEMENTS AND ANTIFOULING COATING COMPOSITION |
US6143037A (en) | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
US5876426A (en) | 1996-06-13 | 1999-03-02 | Scimed Life Systems, Inc. | System and method of providing a blood-free interface for intravascular light delivery |
FR2750897B1 (en) | 1996-07-10 | 1998-09-18 | Sames Sa | TRIBOELECTRIC PROJECTOR, COATING PRODUCT PROJECTION INSTALLATION AND METHOD FOR CONTROLLING SUCH A PROJECTOR |
EP0937082A2 (en) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
JPH1029524A (en) | 1996-07-15 | 1998-02-03 | Toyota Motor Corp | Wheel slip controller |
US5871436A (en) | 1996-07-19 | 1999-02-16 | Advanced Cardiovascular Systems, Inc. | Radiation therapy method and device |
CA2211249C (en) | 1996-07-24 | 2007-07-17 | Cordis Corporation | Balloon catheter and methods of use |
US6013855A (en) | 1996-08-06 | 2000-01-11 | United States Surgical | Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces |
DE19633901A1 (en) | 1996-08-22 | 1998-02-26 | Thomas Prof Dr Med Ischinger | Vascular support in the form of a tube section-like support structure |
US6884377B1 (en) | 1996-08-27 | 2005-04-26 | Trexel, Inc. | Method and apparatus for microcellular polymer extrusion |
US5807404A (en) | 1996-09-19 | 1998-09-15 | Medinol Ltd. | Stent with variable features to optimize support and method of making such stent |
US6193963B1 (en) | 1996-10-17 | 2001-02-27 | The Regents Of The University Of California | Method of treating tumor-bearing patients with human plasma hyaluronidase |
US6387121B1 (en) | 1996-10-21 | 2002-05-14 | Inflow Dynamics Inc. | Vascular and endoluminal stents with improved coatings |
US6530951B1 (en) | 1996-10-24 | 2003-03-11 | Cook Incorporated | Silver implantable medical device |
GB9623634D0 (en) | 1996-11-13 | 1997-01-08 | Bpsi Holdings Inc | Method and apparatus for the coating of substrates for pharmaceutical use |
US6251980B1 (en) | 1996-12-06 | 2001-06-26 | Amcol International Corporation | Nanocomposites formed by onium ion-intercalated clay and rigid anhydride-cured epoxy resins |
US5871437A (en) | 1996-12-10 | 1999-02-16 | Inflow Dynamics, Inc. | Radioactive stent for treating blood vessels to prevent restenosis |
US6517860B1 (en) | 1996-12-31 | 2003-02-11 | Quadrant Holdings Cambridge, Ltd. | Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery |
FR2758253B1 (en) | 1997-01-10 | 1999-04-02 | Nycomed Lab Sa | IMPLANTABLE DEVICE FOR THE TREATMENT OF A BODY DUCT |
US6884823B1 (en) | 1997-01-16 | 2005-04-26 | Trexel, Inc. | Injection molding of polymeric material |
DE29702671U1 (en) | 1997-02-17 | 1997-04-10 | Jomed Implantate Gmbh | Stent |
ES2388248T3 (en) | 1997-03-31 | 2012-10-11 | Boston Scientific Scimed Limited | Dosage form comprising taxol in crystalline form |
US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
IT1292295B1 (en) | 1997-04-29 | 1999-01-29 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT |
FR2762777B1 (en) | 1997-05-05 | 1999-10-22 | Patrick Sabaria | VASCULAR AND CORONARY EXTENDERS, USUALLY DESIGNATED UNDER THE NAME OF "STENT" |
GB9800936D0 (en) | 1997-05-10 | 1998-03-11 | Univ Nottingham | Biofunctional polymers |
CA2308396A1 (en) | 1997-05-14 | 1998-11-19 | Novo Rps Ulc | Expandable stent and method for production of same |
DE19720115C2 (en) | 1997-05-14 | 1999-05-20 | Jomed Implantate Gmbh | Stent graft |
DE29708689U1 (en) | 1997-05-15 | 1997-07-17 | Jomed Implantate Gmbh | Coronary stent |
US5913895A (en) | 1997-06-02 | 1999-06-22 | Isostent, Inc. | Intravascular stent with enhanced rigidity strut members |
US6416779B1 (en) | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
US6433154B1 (en) | 1997-06-12 | 2002-08-13 | Bristol-Myers Squibb Company | Functional receptor/kinase chimera in yeast cells |
US6245103B1 (en) | 1997-08-01 | 2001-06-12 | Schneider (Usa) Inc | Bioabsorbable self-expanding stent |
US6077880A (en) | 1997-08-08 | 2000-06-20 | Cordis Corporation | Highly radiopaque polyolefins and method for making the same |
AU8782098A (en) | 1997-08-13 | 1999-03-08 | Boston Scientific Limited | Loading and release of water-insoluble drugs |
DE69832089T2 (en) | 1997-08-28 | 2006-07-20 | Nissan Chemical Industries, Ltd. | MEANS FOR PROMOTING AND REINFORCING NEOVASCULARIZATION |
DE29716476U1 (en) | 1997-09-13 | 1997-12-18 | Convent Gerd | Stenosis treatment stent |
DE29716467U1 (en) | 1997-09-15 | 1998-02-26 | Loh Kg Rittal Werk | Housing structure for electrical or electronic installations |
US7378105B2 (en) | 1997-09-26 | 2008-05-27 | Abbott Laboratories | Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens |
TW557297B (en) | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
US8257725B2 (en) | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
US6042606A (en) | 1997-09-29 | 2000-03-28 | Cook Incorporated | Radially expandable non-axially contracting surgical stent |
US6071308A (en) | 1997-10-01 | 2000-06-06 | Boston Scientific Corporation | Flexible metal wire stent |
US6127000A (en) | 1997-10-10 | 2000-10-03 | North Carolina State University | Method and compositions for protecting civil infrastructure |
DE69838952T2 (en) | 1997-11-07 | 2009-01-02 | Salviac Ltd. | EMBOLISM PROTECTION DEVICE |
ES2201571T3 (en) | 1997-11-24 | 2004-03-16 | Morphoplant Gmbh | PROCEDURE FOR THE IMMOBILIZATION OF MEDIATING MOLECULES ON MATERIALS OF INORGANIC AND METALLIC IMPLANTS. |
US5957975A (en) | 1997-12-15 | 1999-09-28 | The Cleveland Clinic Foundation | Stent having a programmed pattern of in vivo degradation |
US6129755A (en) | 1998-01-09 | 2000-10-10 | Nitinol Development Corporation | Intravascular stent having an improved strut configuration |
DE69931472T2 (en) | 1998-03-04 | 2006-09-28 | Boston Scientific Ltd., St. Michael | STENT WITH IMPROVED CELL CONFIGURATION |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
SE9801288D0 (en) | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and method of production |
US8029561B1 (en) | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
GB9808052D0 (en) | 1998-04-17 | 1998-06-17 | Secr Defence | Implants for administering substances and methods of producing implants |
US6206914B1 (en) | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
US6190699B1 (en) | 1998-05-08 | 2001-02-20 | Nzl Corporation | Method of incorporating proteins or peptides into a matrix and administration thereof through mucosa |
DE19822157B4 (en) | 1998-05-16 | 2013-01-10 | Abbott Laboratories Vascular Enterprises Ltd. | Radially expandable stent for implantation in a body vessel |
FR2780057B1 (en) | 1998-06-18 | 2002-09-13 | Sanofi Sa | PHENOXYPROPANOLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
AU4699799A (en) | 1998-06-19 | 2000-01-05 | Oxibio, Inc. | Medical device having anti-infective and contraceptive properties |
US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
US7004962B2 (en) | 1998-07-27 | 2006-02-28 | Schneider (Usa), Inc. | Neuroaneurysm occlusion and delivery device and method of using same |
US7967855B2 (en) | 1998-07-27 | 2011-06-28 | Icon Interventional Systems, Inc. | Coated medical device |
US8070796B2 (en) | 1998-07-27 | 2011-12-06 | Icon Interventional Systems, Inc. | Thrombosis inhibiting graft |
US6461380B1 (en) | 1998-07-28 | 2002-10-08 | Advanced Cardiovascular Systems, Inc. | Stent configuration |
US6248127B1 (en) | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
US6193744B1 (en) | 1998-09-10 | 2001-02-27 | Scimed Life Systems, Inc. | Stent configurations |
US6342062B1 (en) | 1998-09-24 | 2002-01-29 | Scimed Life Systems, Inc. | Retrieval devices for vena cava filter |
US6363104B1 (en) | 1998-10-02 | 2002-03-26 | Ericsson Inc. | Method and apparatus for interference cancellation in a rake receiver |
US6245104B1 (en) | 1999-02-28 | 2001-06-12 | Inflow Dynamics Inc. | Method of fabricating a biocompatible stent |
US6042597A (en) | 1998-10-23 | 2000-03-28 | Scimed Life Systems, Inc. | Helical stent design |
US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
FR2785174A1 (en) | 1998-11-03 | 2000-05-05 | Jacques Seguin | BODY CONDUIT EXTENSIONER, ESPECIALLY VASCULAR |
US6355691B1 (en) | 1998-11-12 | 2002-03-12 | Tobias M. Goodman | Urushiol therapy of transitional cell carcinoma of the bladder |
US6497729B1 (en) | 1998-11-20 | 2002-12-24 | The University Of Connecticut | Implant coating for control of tissue/implant interactions |
RO121408B1 (en) * | 1998-11-30 | 2007-05-30 | Teva Pharmaceutical Industries Ltd. | Azithromycin ethanolate, process of preparation and pharmaceutical compositions thereof |
WO2000032238A1 (en) | 1998-12-03 | 2000-06-08 | Scimed Life Systems, Inc. | Stent having drug crystals thereon |
US6372246B1 (en) | 1998-12-16 | 2002-04-16 | Ortho-Mcneil Pharmaceutical, Inc. | Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6638727B1 (en) | 1999-01-26 | 2003-10-28 | Cytyc Health Corporation | Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer |
US6706283B1 (en) | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
SE9900519D0 (en) | 1999-02-17 | 1999-02-17 | Lars Lidgren | A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof |
US6171327B1 (en) | 1999-02-24 | 2001-01-09 | Scimed Life Systems, Inc. | Intravascular filter and method |
US6620192B1 (en) | 1999-03-16 | 2003-09-16 | Advanced Cardiovascular Systems, Inc. | Multilayer stent |
SE9901002D0 (en) | 1999-03-19 | 1999-03-19 | Electrolux Ab | Apparatus for cleaning textile articles with a densified liquid processing gas |
US6364903B2 (en) | 1999-03-19 | 2002-04-02 | Meadox Medicals, Inc. | Polymer coated stent |
US6368658B1 (en) | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
US6923979B2 (en) | 1999-04-27 | 2005-08-02 | Microdose Technologies, Inc. | Method for depositing particles onto a substrate using an alternating electric field |
US8016873B1 (en) | 1999-05-03 | 2011-09-13 | Drasler William J | Intravascular hinge stent |
US6726712B1 (en) | 1999-05-14 | 2004-04-27 | Boston Scientific Scimed | Prosthesis deployment device with translucent distal end |
JP2000316981A (en) | 1999-05-14 | 2000-11-21 | Kawasumi Lab Inc | Stent |
US6815218B1 (en) | 1999-06-09 | 2004-11-09 | Massachusetts Institute Of Technology | Methods for manufacturing bioelectronic devices |
CA2376158C (en) | 1999-07-06 | 2011-03-15 | Endorecherche, Inc. | Use of selective estrogen receptor modulators in the manufacture of medicaments for treating and/or suppressing weight gain |
AU783158B2 (en) | 1999-08-24 | 2005-09-29 | Ariad Pharmaceuticals, Inc. | 28-epirapalogs |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6146404A (en) | 1999-09-03 | 2000-11-14 | Scimed Life Systems, Inc. | Removable thrombus filter |
US6358557B1 (en) | 1999-09-10 | 2002-03-19 | Sts Biopolymers, Inc. | Graft polymerization of substrate surfaces |
US6610013B1 (en) | 1999-10-01 | 2003-08-26 | Life Imaging Systems, Inc. | 3D ultrasound-guided intraoperative prostate brachytherapy |
US6755871B2 (en) | 1999-10-15 | 2004-06-29 | R.R. Street & Co. Inc. | Cleaning system utilizing an organic cleaning solvent and a pressurized fluid solvent |
US6458387B1 (en) | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
US7537785B2 (en) | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
US6537310B1 (en) | 1999-11-19 | 2003-03-25 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal implantable devices and method of making same |
US6908624B2 (en) | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6572813B1 (en) | 2000-01-13 | 2003-06-03 | Advanced Cardiovascular Systems, Inc. | Balloon forming process |
TW200800298A (en) | 2000-01-27 | 2008-01-01 | Zentaris Ag | Compressed microparticles for dry injection |
EP1132058A1 (en) | 2000-03-06 | 2001-09-12 | Advanced Laser Applications Holding S.A. | Intravascular prothesis |
EP1145719A3 (en) | 2000-03-10 | 2001-11-14 | Pfizer Products Inc. | Use a ferrous salt for inhibiting oxidative degradation of pharmaceutical formulations |
US8088060B2 (en) * | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
CN2423899Y (en) | 2000-05-08 | 2001-03-21 | 微创医疗器械(上海)有限公司 | Coronary artery stand |
EP1280565A2 (en) | 2000-05-12 | 2003-02-05 | Advanced Bio Prothestic Surfaces, Ltd. | Self-supporting laminated films, structural materials and medical devices |
AU5543801A (en) | 2000-05-16 | 2001-11-26 | Ortho Mcneil Pharm Inc | Process for coating medical devices using super-critical carbon dioxide |
US7217770B2 (en) | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
US20020144757A1 (en) | 2000-07-07 | 2002-10-10 | Craig Charles Horace | Stainless steel alloy with improved radiopaque characteristics |
US20030077200A1 (en) | 2000-07-07 | 2003-04-24 | Craig Charles H. | Enhanced radiopaque alloy stent |
US7332242B2 (en) | 2000-09-01 | 2008-02-19 | Itochu Corporation | Lithium-based battery having extensible, ion-impermeable polymer covering on the battery container |
AU2001287349B2 (en) | 2000-09-01 | 2006-03-02 | Palmaya Pty Ltd | Slow release pharmaceutical preparation and method of administering same |
US6362718B1 (en) | 2000-09-06 | 2002-03-26 | Stephen L. Patrick | Motionless electromagnetic generator |
US6506213B1 (en) | 2000-09-08 | 2003-01-14 | Ferro Corporation | Manufacturing orthopedic parts using supercritical fluid processing techniques |
US6521258B1 (en) | 2000-09-08 | 2003-02-18 | Ferro Corporation | Polymer matrices prepared by supercritical fluid processing techniques |
US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US20020111590A1 (en) | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
US20060222756A1 (en) | 2000-09-29 | 2006-10-05 | Cordis Corporation | Medical devices, drug coatings and methods of maintaining the drug coatings thereon |
EP1330270A2 (en) | 2000-11-03 | 2003-07-30 | Control Delivery Systems, Inc. | Sustained release device for treating conditions of the joint |
US20050084514A1 (en) | 2000-11-06 | 2005-04-21 | Afmedica, Inc. | Combination drug therapy for reducing scar tissue formation |
US20040018228A1 (en) | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
AU2002239491A1 (en) | 2000-11-09 | 2002-05-27 | Vanderbilt University | Methods for the treatment of cancer and other diseases and methods of developing the same |
US6682757B1 (en) | 2000-11-16 | 2004-01-27 | Euro-Celtique, S.A. | Titratable dosage transdermal delivery system |
CN1404405A (en) | 2000-11-30 | 2003-03-19 | 株式会社伊垣医疗设计 | Stent for blood vessel and material for stent for blood vessel |
US6913617B1 (en) | 2000-12-27 | 2005-07-05 | Advanced Cardiovascular Systems, Inc. | Method for creating a textured surface on an implantable medical device |
GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
GB0100760D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
TWI246524B (en) | 2001-01-19 | 2006-01-01 | Shearwater Corp | Multi-arm block copolymers as drug delivery vehicles |
WO2002059184A2 (en) | 2001-01-24 | 2002-08-01 | Virginia Commonwealth University | Molecular imprinting of small particles, and production of small particles from solid state reactants |
PL201766B1 (en) | 2001-01-31 | 2009-05-29 | Roehm Gmbh | Multi-particulate form of medicament, comprising at least two differently coated forms of pellet |
US20040220660A1 (en) | 2001-02-05 | 2004-11-04 | Shanley John F. | Bioresorbable stent with beneficial agent reservoirs |
DE10106810A1 (en) | 2001-02-14 | 2002-09-05 | Siemens Ag | Off-grid power supply unit |
US6905555B2 (en) | 2001-02-15 | 2005-06-14 | Micell Technologies, Inc. | Methods for transferring supercritical fluids in microelectronic and other industrial processes |
US6811549B2 (en) | 2001-02-16 | 2004-11-02 | William H. Fleming | Administration of therapeutic or diagnostic agents using interlabial pad |
US6720003B2 (en) | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
US7771468B2 (en) | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
WO2002074194A2 (en) | 2001-03-16 | 2002-09-26 | Sts Biopolymers, Inc. | Stent with medicated multi-layer hydrid polymer coating |
US7282020B2 (en) | 2001-04-24 | 2007-10-16 | Microspherix Llc | Deflectable implantation device and method of use |
US20040022853A1 (en) | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
US7247338B2 (en) | 2001-05-16 | 2007-07-24 | Regents Of The University Of Minnesota | Coating medical devices |
US6973718B2 (en) | 2001-05-30 | 2005-12-13 | Microchips, Inc. | Methods for conformal coating and sealing microchip reservoir devices |
US7201940B1 (en) | 2001-06-12 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for thermal spray processing of medical devices |
US20030044514A1 (en) | 2001-06-13 | 2003-03-06 | Richard Robert E. | Using supercritical fluids to infuse therapeutic on a medical device |
US7485113B2 (en) | 2001-06-22 | 2009-02-03 | Johns Hopkins University | Method for drug delivery through the vitreous humor |
US7501157B2 (en) | 2001-06-26 | 2009-03-10 | Accelr8 Technology Corporation | Hydroxyl functional surface coating |
US7015875B2 (en) | 2001-06-29 | 2006-03-21 | Novus Partners Llc | Dynamic device for billboard advertising |
US6967234B2 (en) | 2002-12-18 | 2005-11-22 | Ethicon, Inc. | Alkyd-lactone copolymers for medical applications |
US6585755B2 (en) | 2001-06-29 | 2003-07-01 | Advanced Cardiovascular | Polymeric stent suitable for imaging by MRI and fluoroscopy |
US6743505B2 (en) | 2001-07-27 | 2004-06-01 | Ethicon, Inc. | Bioabsorbable multifilament yarn and methods of manufacture |
US6723913B1 (en) | 2001-08-23 | 2004-04-20 | Anthony T. Barbetta | Fan cooling of active speakers |
US6669980B2 (en) | 2001-09-18 | 2003-12-30 | Scimed Life Systems, Inc. | Method for spray-coating medical devices |
IL161335A0 (en) | 2001-10-15 | 2004-09-27 | Hemoteq Gmbh | Coating of stents for preventing restenosis |
US20030088307A1 (en) * | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
CA2466336A1 (en) | 2001-11-09 | 2003-05-15 | Ebrahim Versi | Anti-muscarinic agent and estrogen-agonist for treating unstable or overactive bladder |
US6517889B1 (en) | 2001-11-26 | 2003-02-11 | Swaminathan Jayaraman | Process for coating a surface of a stent |
US7488313B2 (en) | 2001-11-29 | 2009-02-10 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
US6868123B2 (en) | 2001-12-07 | 2005-03-15 | Motorola, Inc. | Programmable motion estimation module with vector array unit |
TW497494U (en) | 2001-12-28 | 2002-08-01 | Metal Ind Redearch & Amp Dev C | Fluid driven stirring device for compressing gas cleaning system |
DE10200388A1 (en) | 2002-01-08 | 2003-07-24 | Translumina Gmbh | coating system |
TW200730152A (en) | 2002-01-10 | 2007-08-16 | Novartis Ag | Drug delivery systems for the prevention and treatment of vascular diseases |
US20030135256A1 (en) | 2002-01-14 | 2003-07-17 | Gallagher Brendan P. | Stent delivery system |
US20060093771A1 (en) | 2002-02-15 | 2006-05-04 | Frantisek Rypacek | Polymer coating for medical devices |
KR20040097126A (en) | 2002-02-15 | 2004-11-17 | 씨브이 쎄러퓨틱스, 인코포레이티드 | Polymer coating for medical devices |
KR20040093058A (en) | 2002-02-28 | 2004-11-04 | 노파르티스 아게 | N-(5-(4-(4-methyl-piperazino-methyl)-benzoylamido)-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine coated stents |
US20030232014A1 (en) | 2002-03-01 | 2003-12-18 | Mds Proteomics Inc. | Phosphorylated proteins and uses related thereto |
GB0205868D0 (en) | 2002-03-13 | 2002-04-24 | Univ Nottingham | Polymer composite with internally distributed deposition matter |
US7919075B1 (en) | 2002-03-20 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
US6743463B2 (en) | 2002-03-28 | 2004-06-01 | Scimed Life Systems, Inc. | Method for spray-coating a medical device having a tubular wall such as a stent |
US7470281B2 (en) | 2002-04-26 | 2008-12-30 | Medtronic Vascular, Inc. | Coated stent with crimpable coating |
US6669785B2 (en) | 2002-05-15 | 2003-12-30 | Micell Technologies, Inc. | Methods and compositions for etch cleaning microelectronic substrates in carbon dioxide |
US6749902B2 (en) | 2002-05-28 | 2004-06-15 | Battelle Memorial Institute | Methods for producing films using supercritical fluid |
US6780475B2 (en) | 2002-05-28 | 2004-08-24 | Battelle Memorial Institute | Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions |
PT1507600E (en) | 2002-05-28 | 2010-06-04 | Battelle Memorial Institute | Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions |
US6756084B2 (en) | 2002-05-28 | 2004-06-29 | Battelle Memorial Institute | Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions |
US7229837B2 (en) | 2002-05-30 | 2007-06-12 | Uchicago Argonne, Llc | Enhanced photophysics of conjugated polymers |
TW200403065A (en) | 2002-05-30 | 2004-03-01 | Akzo Nobel Nv | New etonogestrel esters |
CA2489362A1 (en) | 2002-06-13 | 2003-12-24 | Kappler, Inc. | Microporous membrane with adsorbent multi-functional filler |
US6794902B2 (en) | 2002-06-14 | 2004-09-21 | Sun Microsystems, Inc. | Virtual ground circuit |
US7217426B1 (en) | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
US7033602B1 (en) | 2002-06-21 | 2006-04-25 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of coating implantable medical devices |
US6839913B2 (en) | 2002-06-25 | 2005-01-11 | Noble Ideas, Inc. | Adjustable garment waistband and method of manufacture |
CN100471469C (en) | 2002-06-27 | 2009-03-25 | 微创医疗器械(上海)有限公司 | Drug-eluting stent (DES) with multicoating |
EP1516597A4 (en) | 2002-06-27 | 2010-11-10 | Microport Medical Shanghai Co | Drug eluting stent |
US20040013792A1 (en) | 2002-07-19 | 2004-01-22 | Samuel Epstein | Stent coating holders |
US7491233B1 (en) | 2002-07-19 | 2009-02-17 | Advanced Cardiovascular Systems Inc. | Purified polymers for coatings of implantable medical devices |
JP2004058431A (en) | 2002-07-29 | 2004-02-26 | Nitto Denko Corp | Pressure-sensitive adhesive tape or sheet |
GB2391439B (en) | 2002-07-30 | 2006-06-21 | Wolfson Ltd | Bass compressor |
US20050019747A1 (en) | 2002-08-07 | 2005-01-27 | Anderson Daniel G. | Nanoliter-scale synthesis of arrayed biomaterials and screening thereof |
US7029495B2 (en) | 2002-08-28 | 2006-04-18 | Scimed Life Systems, Inc. | Medical devices and methods of making the same |
US7060051B2 (en) | 2002-09-24 | 2006-06-13 | Scimed Life Systems, Inc. | Multi-balloon catheter with hydrogel coating |
JP2006500996A (en) | 2002-09-26 | 2006-01-12 | エンドバスキュラー デバイセス インコーポレイテッド | Apparatus and method for delivering mitomycin via an eluting biocompatible implantable medical device |
US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
US6702850B1 (en) | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
DE60336158D1 (en) | 2002-10-11 | 2011-04-07 | Univ Connecticut | ON SEMICRISTALLINE THERMOPLASTIC POLYURETHANES BASED FOR NANOSTRUCTURED HARD SEGMENTS BASED FORM MEMORY PILARMERS |
US6800663B2 (en) | 2002-10-18 | 2004-10-05 | Alkermes Controlled Therapeutics Inc. Ii, | Crosslinked hydrogel copolymers |
KR100511030B1 (en) | 2002-10-21 | 2005-08-31 | 한국과학기술연구원 | Blood compatible metallic materials and preparation thereof |
AU2003295422B2 (en) | 2002-11-07 | 2009-01-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A new target for angiogenesis and anti-angiogenesis therapy |
US20060121080A1 (en) | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
US20050070989A1 (en) | 2002-11-13 | 2005-03-31 | Whye-Kei Lye | Medical devices having porous layers and methods for making the same |
US20040098106A1 (en) | 2002-11-14 | 2004-05-20 | Williams Michael S. | Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents |
WO2004045450A2 (en) | 2002-11-15 | 2004-06-03 | Synecor, Llc | Improved endoprostheses and methods of manufacture |
JP4987232B2 (en) | 2002-11-18 | 2012-07-25 | ラットガーズ,ザ・ステート・ユニバーシティ・オブ・ニュージャージー | Medical devices using new polymers |
JP4371653B2 (en) | 2002-11-25 | 2009-11-25 | テルモ株式会社 | Implantable medical device |
US6790483B2 (en) | 2002-12-06 | 2004-09-14 | Eastman Kodak Company | Method for producing patterned deposition from compressed fluid |
US7094256B1 (en) | 2002-12-16 | 2006-08-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical device containing polycationic peptides |
JP4917263B2 (en) | 2002-12-23 | 2012-04-18 | バイカル インコーポレイテッド | Method for lyophilizing nucleic acid / block copolymer / cationic surfactant complex |
US7152452B2 (en) | 2002-12-26 | 2006-12-26 | Advanced Cardiovascular Systems, Inc. | Assembly for crimping an intraluminal device and method of use |
US20040143317A1 (en) | 2003-01-17 | 2004-07-22 | Stinson Jonathan S. | Medical devices |
JP2004225126A (en) | 2003-01-24 | 2004-08-12 | Pioneer Electronic Corp | Film deposition mask, and method for manufacturing the same |
US20050079199A1 (en) | 2003-02-18 | 2005-04-14 | Medtronic, Inc. | Porous coatings for drug release from medical devices |
EP1603485A4 (en) | 2003-02-26 | 2011-03-30 | Medivas Llc | Bioactive stents and methods for use thereof |
US20080051866A1 (en) | 2003-02-26 | 2008-02-28 | Chao Chin Chen | Drug delivery devices and methods |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
US20040193262A1 (en) | 2003-03-29 | 2004-09-30 | Shadduck John H. | Implants for treating ocular hypertension, methods of use and methods of fabrication |
US7527632B2 (en) | 2003-03-31 | 2009-05-05 | Cordis Corporation | Modified delivery device for coated medical devices |
US7326734B2 (en) | 2003-04-01 | 2008-02-05 | The Regents Of The University Of California | Treatment of bladder and urinary tract cancers |
US20050216075A1 (en) | 2003-04-08 | 2005-09-29 | Xingwu Wang | Materials and devices of enhanced electromagnetic transparency |
US20060102871A1 (en) | 2003-04-08 | 2006-05-18 | Xingwu Wang | Novel composition |
US7537803B2 (en) | 2003-04-08 | 2009-05-26 | New Jersey Institute Of Technology | Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process |
US20050208102A1 (en) | 2003-04-09 | 2005-09-22 | Schultz Clyde L | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
US20050038498A1 (en) | 2003-04-17 | 2005-02-17 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
US8246974B2 (en) | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
GB0310300D0 (en) | 2003-05-06 | 2003-06-11 | Univ Belfast | Nanocomposite drug delivery composition |
US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
US20040236416A1 (en) | 2003-05-20 | 2004-11-25 | Robert Falotico | Increased biocompatibility of implantable medical devices |
US7662864B2 (en) | 2003-06-04 | 2010-02-16 | Rutgers, The State University Of New Jersey | Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent |
EP1649928A4 (en) | 2003-06-06 | 2008-07-09 | Mitsubishi Chem Corp | Water-absorbent articles and process for the production thereof |
WO2004113429A2 (en) | 2003-06-23 | 2004-12-29 | The University Of Chicago | Polyolefin nanocomposites |
US7318945B2 (en) | 2003-07-09 | 2008-01-15 | Medtronic Vascular, Inc. | Laminated drug-polymer coated stent having dipped layers |
US8025637B2 (en) | 2003-07-18 | 2011-09-27 | Boston Scientific Scimed, Inc. | Medical balloons and processes for preparing same |
US7128277B2 (en) | 2003-07-29 | 2006-10-31 | Illinois Tool Works Inc. | Powder bell with secondary charging electrode |
US7056591B1 (en) | 2003-07-30 | 2006-06-06 | Advanced Cardiovascular Systems, Inc. | Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same |
US7169404B2 (en) | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
US20050033417A1 (en) | 2003-07-31 | 2005-02-10 | John Borges | Coating for controlled release of a therapeutic agent |
US20070038289A1 (en) | 2003-08-05 | 2007-02-15 | Kaneka Corporation | Stent to be placed in vivo |
US7318944B2 (en) | 2003-08-07 | 2008-01-15 | Medtronic Vascular, Inc. | Extrusion process for coating stents |
ATE454138T1 (en) | 2003-08-08 | 2010-01-15 | Biovail Lab Int Srl | MODIFIED RELEASE TABLET OF BUPROPION HYDROCHLORIDE |
JP2007502281A (en) | 2003-08-13 | 2007-02-08 | メドトロニック・インコーポレーテッド | Active agent release system, medical device and method comprising a miscible polymer formulation |
US7204560B2 (en) | 2003-08-15 | 2007-04-17 | Sandvik Intellectual Property Ab | Rotary cutting bit with material-deflecting ledge |
CN101094622A (en) | 2003-09-18 | 2007-12-26 | 先进生物假体表面有限公司 | Medical devices having mems functionality and methods of making same |
US8801692B2 (en) | 2003-09-24 | 2014-08-12 | Medtronic Vascular, Inc. | Gradient coated stent and method of fabrication |
US20050070990A1 (en) | 2003-09-26 | 2005-03-31 | Stinson Jonathan S. | Medical devices and methods of making same |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
US7618647B2 (en) | 2003-10-03 | 2009-11-17 | Boston Scientific Scimed, Inc. | Using bucky paper as a therapeutic aid in medical applications |
US6984411B2 (en) | 2003-10-14 | 2006-01-10 | Boston Scientific Scimed, Inc. | Method for roll coating multiple stents |
US7329383B2 (en) | 2003-10-22 | 2008-02-12 | Boston Scientific Scimed, Inc. | Alloy compositions and devices including the compositions |
US20070254035A1 (en) | 2003-10-23 | 2007-11-01 | Jianyuan Hao | Preparing Active Polymer Extrudates |
JP4806355B2 (en) | 2003-12-16 | 2011-11-02 | サイテック サーフェース スペシャリティーズ、エス.エイ. | Method for applying a coating to a coiled metal sheet |
US20050131513A1 (en) | 2003-12-16 | 2005-06-16 | Cook Incorporated | Stent catheter with a permanently affixed conductor |
WO2005063319A1 (en) | 2003-12-24 | 2005-07-14 | Novartis Ag | Parmaceutical compositions |
US20050147734A1 (en) | 2004-01-07 | 2005-07-07 | Jan Seppala | Method and system for coating tubular medical devices |
US20050268573A1 (en) | 2004-01-20 | 2005-12-08 | Avantec Vascular Corporation | Package of sensitive articles |
US7306677B2 (en) | 2004-01-30 | 2007-12-11 | Boston Scientific Corporation | Clamping fixture for coating stents, system using the fixture, and method of using the fixture |
GB2411078B (en) | 2004-02-10 | 2009-02-04 | Samsung Electronics Co Ltd | Mobile communications |
US7241344B2 (en) | 2004-02-10 | 2007-07-10 | Boston Scientific Scimed, Inc. | Apparatus and method for electrostatic spray coating of medical devices |
US8551512B2 (en) | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
EP1732619A1 (en) | 2004-03-26 | 2006-12-20 | SurModics, Inc. | Composition and method for preparing biocompatible surfaces |
US7335264B2 (en) | 2004-04-22 | 2008-02-26 | Boston Scientific Scimed, Inc. | Differentially coated medical devices, system for differentially coating medical devices, and coating method |
US7820732B2 (en) | 2004-04-30 | 2010-10-26 | Advanced Cardiovascular Systems, Inc. | Methods for modulating thermal and mechanical properties of coatings on implantable devices |
US20050288481A1 (en) | 2004-04-30 | 2005-12-29 | Desnoyer Jessica R | Design of poly(ester amides) for the control of agent-release from polymeric compositions |
WO2005117942A2 (en) | 2004-05-14 | 2005-12-15 | The Regents Of The University Of Michigan | Methods for encapsulation of biomacromolecules in polymers |
US7815922B2 (en) | 2004-05-14 | 2010-10-19 | Becton, Dickinson And Company | Articles having bioactive surfaces and solvent-free methods of preparation thereof |
US7682656B2 (en) | 2004-06-14 | 2010-03-23 | Agruim Inc. | Process and apparatus for producing a coated product |
US7976557B2 (en) | 2004-06-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Cutting balloon and process |
CA2511212A1 (en) | 2004-07-02 | 2006-01-02 | Henkel Kommanditgesellschaft Auf Aktien | Surface conditioner for powder coating systems |
EP2359842A1 (en) | 2004-07-14 | 2011-08-24 | University of Utah Research Foundation | Netrin-related compositions and uses |
US20060020325A1 (en) | 2004-07-26 | 2006-01-26 | Robert Burgermeister | Material for high strength, controlled recoil stent |
US8541078B2 (en) | 2004-08-06 | 2013-09-24 | Societe Bic | Fuel supplies for fuel cells |
US7425368B2 (en) | 2004-08-20 | 2008-09-16 | Massachusetts Institute Of Technology | Filler-enhanced polymeric fibers with improved mechanical properties and method for making |
US8119153B2 (en) | 2004-08-26 | 2012-02-21 | Boston Scientific Scimed, Inc. | Stents with drug eluting coatings |
US20080077232A1 (en) | 2004-09-08 | 2008-03-27 | Kaneka Corporation | Stent for Placement in Body |
CN101076319A (en) | 2004-09-29 | 2007-11-21 | 科迪斯公司 | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
US8313763B2 (en) | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
US20060093643A1 (en) | 2004-11-04 | 2006-05-04 | Stenzel Eric B | Medical device for delivering therapeutic agents over different time periods |
US7455658B2 (en) | 2004-11-10 | 2008-11-25 | Samw Hong Jen Wang | Fluid dispensing or feeding device |
US7455688B2 (en) | 2004-11-12 | 2008-11-25 | Con Interventional Systems, Inc. | Ostial stent |
US20060134168A1 (en) | 2004-12-07 | 2006-06-22 | Chappa Ralph A | Coatings with crystallized active agent(s) and methods |
US20070059350A1 (en) | 2004-12-13 | 2007-03-15 | Kennedy John P | Agents for controlling biological fluids and methods of use thereof |
US7632307B2 (en) | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
WO2006063430A1 (en) | 2004-12-16 | 2006-06-22 | Miv Therapeutics Inc. | Multi-layer drug delivery device and method of manufacturing same |
US8292944B2 (en) | 2004-12-17 | 2012-10-23 | Reva Medical, Inc. | Slide-and-lock stent |
US20060198868A1 (en) | 2005-01-05 | 2006-09-07 | Dewitt David M | Biodegradable coating compositions comprising blends |
US7727273B2 (en) | 2005-01-13 | 2010-06-01 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
US7772352B2 (en) | 2005-01-28 | 2010-08-10 | Bezwada Biomedical Llc | Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices |
WO2006110197A2 (en) | 2005-03-03 | 2006-10-19 | Icon Medical Corp. | Polymer biodegradable medical device |
US7837726B2 (en) | 2005-03-14 | 2010-11-23 | Abbott Laboratories | Visible endoprosthesis |
KR20070116821A (en) | 2005-03-14 | 2007-12-11 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Biocompatible polymer compounds for medicinal formulations |
EA200701998A1 (en) | 2005-03-17 | 2008-02-28 | Элан Фарма Интернэшнл Лтд. | COMPOSITIONS FOR INJECTION OF NANOPARTICLES IMMUNE DEPRESSIVE COMPOUNDS |
EP2327429B1 (en) | 2005-03-23 | 2014-09-17 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
US8628565B2 (en) | 2005-04-13 | 2014-01-14 | Abbott Cardiovascular Systems Inc. | Intravascular stent |
US20070009564A1 (en) | 2005-06-22 | 2007-01-11 | Mcclain James B | Drug/polymer composite materials and methods of making the same |
CA2615452C (en) | 2005-07-15 | 2015-03-31 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US20090062909A1 (en) | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
US20070026042A1 (en) | 2005-07-29 | 2007-02-01 | Narayanan Pallasssana V | System for treating aneurysmal disease |
WO2007014464A1 (en) | 2005-08-03 | 2007-02-08 | The University Of Western Ontario | Direct coating solid dosage forms using powdered materials |
USRE46273E1 (en) | 2005-08-05 | 2017-01-10 | Telecom Italia S.P.A. | Method of establishing a connection on a communication network |
WO2007017707A1 (en) | 2005-08-11 | 2007-02-15 | Hilary Nwokeabia | The slanting toothbrush |
US8343170B2 (en) | 2005-08-12 | 2013-01-01 | Massicotte J Mathieu | Method and device for extracting objects from the body |
US20070043434A1 (en) | 2005-08-18 | 2007-02-22 | David Meerkin | Biodegradable endovascular stent using stereocomplexation of polymers |
EP1764116A1 (en) | 2005-09-16 | 2007-03-21 | Debiotech S.A. | Porous coating process using colloidal particles |
US7935379B2 (en) | 2005-11-14 | 2011-05-03 | Boston Scientific Scimed, Inc. | Coated and imprinted medical devices and methods of making the same |
US20070196423A1 (en) | 2005-11-21 | 2007-08-23 | Med Institute, Inc. | Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent |
JP2009518479A (en) | 2005-12-09 | 2009-05-07 | ディーエスエム アイピー アセッツ ビー.ブイ. | Hydrophilic coating containing polyelectrolyte |
US20070148251A1 (en) | 2005-12-22 | 2007-06-28 | Hossainy Syed F A | Nanoparticle releasing medical devices |
US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
US8834912B2 (en) | 2005-12-30 | 2014-09-16 | Boston Scientific Scimed, Inc. | Medical devices having multiple charged layers |
US7919108B2 (en) | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
US20080286325A1 (en) | 2006-01-05 | 2008-11-20 | Med Institute, Inc. | Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent |
US8142509B2 (en) | 2006-01-23 | 2012-03-27 | Smith & Nephew, Inc. | Patellar components |
JP2009525768A (en) | 2006-01-27 | 2009-07-16 | エム イー ディ インスチィチュート インク | Device with nanocomposite coating for controlled release of drugs |
EP1986923A4 (en) | 2006-02-23 | 2012-12-19 | Agamatrix Inc | Used test strip storage container |
US20070200268A1 (en) | 2006-02-24 | 2007-08-30 | Vipul Dave | Implantable device prepared from solution processing |
US20070203569A1 (en) | 2006-02-24 | 2007-08-30 | Robert Burgermeister | Implantable device formed from polymer blends having modified molecular structures |
US8500772B2 (en) | 2006-03-20 | 2013-08-06 | Cook Medical Technologies Llc | Distal protection device |
US20070225795A1 (en) | 2006-03-24 | 2007-09-27 | Juan Granada | Composite vascular prosthesis |
US7955383B2 (en) | 2006-04-25 | 2011-06-07 | Medtronics Vascular, Inc. | Laminated implantable medical device having a metallic coating |
CA2996768C (en) * | 2006-04-26 | 2020-12-08 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US7691400B2 (en) | 2006-05-05 | 2010-04-06 | Medtronic Vascular, Inc. | Medical device having coating with zeolite drug reservoirs |
US20080279909A1 (en) | 2006-05-12 | 2008-11-13 | Cleek Robert L | Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization |
US7959940B2 (en) | 2006-05-30 | 2011-06-14 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical devices |
US20070281117A1 (en) | 2006-06-02 | 2007-12-06 | Xtent, Inc. | Use of plasma in formation of biodegradable stent coating |
US20080124372A1 (en) | 2006-06-06 | 2008-05-29 | Hossainy Syed F A | Morphology profiles for control of agent release rates from polymer matrices |
BRPI0603437A2 (en) | 2006-06-06 | 2010-07-06 | Luiz Gonzaga Granja Jr | extraluminal stent anastomosis prosthesis |
US8535372B1 (en) | 2006-06-16 | 2013-09-17 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent with prohealing layer |
WO2008008291A2 (en) | 2006-07-13 | 2008-01-17 | Icon Medical Corp. | Stent |
US7812032B2 (en) | 2006-07-25 | 2010-10-12 | Abbott Laboratories | Crystalline forms of rapamycin analogs |
US20080065192A1 (en) | 2006-09-13 | 2008-03-13 | Medtronic Vascular, Inc. | Compliance Graded Stent |
EP2702993B1 (en) | 2006-09-13 | 2017-12-06 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
WO2008033603A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices having alloy compositions |
WO2008036554A2 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
WO2008039749A2 (en) | 2006-09-25 | 2008-04-03 | Surmodics, Inc. | Multi-layered coatings and methods for controlling elution of active agents |
WO2008042909A2 (en) | 2006-10-02 | 2008-04-10 | Micell Technologies Inc. | Surgical sutures having increased strength |
EP1916006A1 (en) | 2006-10-19 | 2008-04-30 | Albert Schömig | Implant coated with a wax or a resin |
EP1913960A1 (en) | 2006-10-19 | 2008-04-23 | Albert Schömig | Coated implant |
US20080097591A1 (en) | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
CA2667228C (en) | 2006-10-23 | 2015-07-14 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US20080098178A1 (en) | 2006-10-23 | 2008-04-24 | Veazey Judson E | Data storage on a switching system coupling multiple processors of a computer system |
US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
EP2101779A1 (en) | 2006-12-13 | 2009-09-23 | Angiotech Pharmaceuticals, Inc. | Medical implants with a combination of compounds |
US8114466B2 (en) | 2007-01-03 | 2012-02-14 | Boston Scientific Scimed, Inc. | Methods of applying coating to the inside surface of a stent |
CA2679712C (en) | 2007-01-08 | 2016-11-15 | Micell Technologies, Inc. | Stents having biodegradable layers |
US20130150943A1 (en) | 2007-01-19 | 2013-06-13 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
US7745566B2 (en) | 2007-01-23 | 2010-06-29 | Ferro Corporation | Methods for the purification of polymers |
US7887830B2 (en) | 2007-02-27 | 2011-02-15 | Boston Scientific Scimed, Inc. | Medical devices having polymeric regions based on styrene-isobutylene copolymers |
EP2137696A2 (en) | 2007-03-16 | 2009-12-30 | STI Medical Systems, LLC | A method to provide automated quality feedback to imaging devices to achieve standardized imaging data |
US7815962B2 (en) | 2007-03-22 | 2010-10-19 | Medtronic Vascular, Inc. | Coated stent with evenly distributed therapeutic agent |
WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
CA2684482C (en) | 2007-04-17 | 2014-08-12 | Micell Technologies, Inc. | Stents having biodegradable layers |
US20100166869A1 (en) | 2007-05-03 | 2010-07-01 | Desai Neil P | Methods and compositions for treating pulmonary hypertension |
WO2008144600A1 (en) | 2007-05-17 | 2008-11-27 | Prescient Medical, Inc. | Multi-channel fiber optic spectroscopy systems employing integrated optics modules |
GB0709517D0 (en) | 2007-05-17 | 2007-06-27 | Queen Mary & Westfield College | An electrostatic spraying device and a method of electrostatic spraying |
AU2008256684B2 (en) | 2007-05-25 | 2012-06-14 | Micell Technologies, Inc. | Polymer films for medical device coating |
US7922760B2 (en) | 2007-05-29 | 2011-04-12 | Abbott Cardiovascular Systems Inc. | In situ trapping and delivery of agent by a stent having trans-strut depots |
US20090068266A1 (en) | 2007-09-11 | 2009-03-12 | Raheja Praveen | Sirolimus having specific particle size and pharmaceutical compositions thereof |
US20090076446A1 (en) | 2007-09-14 | 2009-03-19 | Quest Medical, Inc. | Adjustable catheter for dilation in the ear, nose or throat |
US20100197711A1 (en) | 2007-09-27 | 2010-08-05 | Keith Geoffrey Watson | Benzothiazole compounds |
US8709071B1 (en) | 2007-09-28 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Stent with preferential coating |
JP5114788B2 (en) | 2007-09-28 | 2013-01-09 | 三菱重工業株式会社 | Lithium secondary battery |
US20090105687A1 (en) | 2007-10-05 | 2009-04-23 | Angioscore, Inc. | Scoring catheter with drug delivery membrane |
DK2214646T3 (en) | 2007-10-05 | 2021-10-04 | Univ Wayne State | DENDRIMERS FOR SUSTAINED RELEASE OF COMPOUNDS |
WO2009051780A1 (en) | 2007-10-19 | 2009-04-23 | Micell Technologies, Inc. | Drug coated stents |
EP3505142B1 (en) | 2007-10-19 | 2020-10-28 | CeloNova Biosciences, Inc. | Implantable and lumen-supporting stents |
EP2997985A1 (en) | 2007-10-30 | 2016-03-23 | Nanyang Technological University | A non-biodegradable stent comprising a biodegradable coating and method of coating the same |
US20090111787A1 (en) * | 2007-10-31 | 2009-04-30 | Florencia Lim | Polymer blends for drug delivery stent matrix with improved thermal stability |
US8642062B2 (en) * | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
CN101161300B (en) | 2007-11-27 | 2011-03-16 | 北京美中双和医疗器械有限公司 | Arsenic trioxide medicament elution bracket and its preparation method |
US20090202609A1 (en) | 2008-01-06 | 2009-08-13 | Keough Steven J | Medical device with coating composition |
US20100042206A1 (en) | 2008-03-04 | 2010-02-18 | Icon Medical Corp. | Bioabsorbable coatings for medical devices |
WO2009111716A1 (en) | 2008-03-06 | 2009-09-11 | Boston Scientific Scimed, Inc. | Balloon catheter devices with sheath covering |
EP2271294B1 (en) | 2008-04-17 | 2018-03-28 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
US8557273B2 (en) | 2008-04-18 | 2013-10-15 | Medtronic, Inc. | Medical devices and methods including polymers having biologically active agents therein |
US20110143429A1 (en) | 2008-04-30 | 2011-06-16 | Iksoo Chun | Tissue engineered blood vessels |
CN102017221B (en) | 2008-05-08 | 2013-01-02 | 新日铁化学株式会社 | Compound for organic electroluminescent elements and organic electroluminescent element |
US8298607B2 (en) | 2008-05-15 | 2012-10-30 | Abbott Cardiovascular Systems Inc. | Method for electrostatic coating of a medical device |
US7865562B2 (en) | 2008-05-20 | 2011-01-04 | International Business Machines Corporation | Selecting email signatures |
EP2131614B1 (en) | 2008-05-30 | 2014-01-01 | Alcatel Lucent | Method for transmitting broadcast services in a radiocommunication cellular network through a femto base station, as well as corresponding femto base station |
US20090297578A1 (en) | 2008-06-03 | 2009-12-03 | Trollsas Mikael O | Biosoluble coating comprising anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
US7770466B2 (en) | 2008-07-02 | 2010-08-10 | Abbott Cardiovascular Systems Inc. | Method for measuring stent dislodgement force |
JP4557061B2 (en) | 2008-07-11 | 2010-10-06 | トヨタ自動車株式会社 | Hybrid vehicle and control method thereof |
JP2011528275A (en) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | Drug delivery medical device |
JP2010052503A (en) | 2008-08-27 | 2010-03-11 | Kawano Terukazu | Engine for vessel |
US20100055145A1 (en) | 2008-08-29 | 2010-03-04 | Biosensors International Group | Stent coatings for reducing late stent thrombosis |
US8367090B2 (en) | 2008-09-05 | 2013-02-05 | Abbott Cardiovascular Systems Inc. | Coating on a balloon comprising a polymer and a drug |
WO2010033482A1 (en) | 2008-09-19 | 2010-03-25 | Innovative Surface Technologies, Inc. | Drug eluting superhydrophobic coatings |
JP2012504032A (en) | 2008-09-29 | 2012-02-16 | スターリング ヴァスキュラー システムズ インコーポレイテッド | Drug eluting stent and manufacturing method thereof |
CN104042612A (en) | 2008-11-11 | 2014-09-17 | 得克萨斯大学体系董事会 | Inhibition Of Mammalian Target Of Rapamycin |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
CA2748273C (en) | 2008-12-26 | 2018-01-09 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
US20100198330A1 (en) | 2009-02-02 | 2010-08-05 | Hossainy Syed F A | Bioabsorbable Stent And Treatment That Elicits Time-Varying Host-Material Response |
US9572692B2 (en) | 2009-02-02 | 2017-02-21 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent that modulates plaque geometric morphology and chemical composition |
WO2010086863A2 (en) | 2009-02-02 | 2010-08-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Crystalline drug-containing coatings |
CA2756307C (en) | 2009-03-23 | 2017-08-08 | Micell Technologies, Inc. | Peripheral stents having layers and reinforcement fibers |
US20100239635A1 (en) | 2009-03-23 | 2010-09-23 | Micell Technologies, Inc. | Drug delivery medical device |
WO2010111238A2 (en) | 2009-03-23 | 2010-09-30 | Micell Technologies, Inc. | Improved biodegradable polymers |
CN102481195B (en) | 2009-04-01 | 2015-03-25 | 米歇尔技术公司 | Drug delivery medical device |
US20110301697A1 (en) | 2009-04-10 | 2011-12-08 | Hemoteq Ag | Manufacture, method and use of drug-eluting medical devices for permanently keeping blood vessels open |
US9492587B2 (en) | 2009-04-13 | 2016-11-15 | Abbott Cardiovascular Systems Inc. | Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance |
WO2010121187A2 (en) * | 2009-04-17 | 2010-10-21 | Micell Techologies, Inc. | Stents having controlled elution |
US20100285085A1 (en) | 2009-05-07 | 2010-11-11 | Abbott Cardiovascular Systems Inc. | Balloon coating with drug transfer control via coating thickness |
WO2010136604A1 (en) | 2009-05-29 | 2010-12-02 | Dsm Ip Assets B.V. | Transfer matrix for transferring a bioactive agent to body tissue |
EP2266507B1 (en) | 2009-06-22 | 2015-07-29 | Biotronik VI Patent AG | Stent having improved stent design |
US9327060B2 (en) | 2009-07-09 | 2016-05-03 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Rapamycin reservoir eluting stent |
EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | Drug delivery medical device |
US8039147B2 (en) | 2009-08-27 | 2011-10-18 | Sb Limotive Co., Ltd. | Rechargeable secondary battery having improved safety against puncture and collapse |
US11369498B2 (en) | 2010-02-02 | 2022-06-28 | MT Acquisition Holdings LLC | Stent and stent delivery system with improved deliverability |
EP2550030B1 (en) | 2010-03-25 | 2018-04-25 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
WO2011130448A1 (en) | 2010-04-16 | 2011-10-20 | Micell Technologies, Inc. | Stents having controlled elution |
WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
WO2012034079A2 (en) | 2010-09-09 | 2012-03-15 | Micell Technologies, Inc. | Macrolide dosage forms |
WO2012078955A1 (en) | 2010-12-10 | 2012-06-14 | Micropen Technologies Corporation | Stents and methods of making stents |
US8974622B2 (en) | 2010-12-28 | 2015-03-10 | Boston Scientific Scimed, Inc. | Composite ePTFE-silicone covering for stent |
WO2012092504A2 (en) | 2010-12-30 | 2012-07-05 | Micell Technologies, Inc. | Nanoparticle and surface-modified particulate coatings, coated balloons, and methods therefore |
EP2696815B1 (en) | 2011-04-13 | 2019-03-20 | Micell Technologies, Inc. | Stents having controlled elution |
TW201311226A (en) | 2011-05-06 | 2013-03-16 | Ind Tech Res Inst | Method for manufacturing bioabsorbable stents |
US9446172B2 (en) | 2011-05-10 | 2016-09-20 | Abbott Cardiovascular Systems Inc. | Modification of bioabsorbable stent to reduce thrombogenecity |
WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
WO2013025535A1 (en) | 2011-08-12 | 2013-02-21 | Micell Technologies, Inc. | Stents having controlled elution |
CN106421933A (en) | 2011-10-18 | 2017-02-22 | 米歇尔技术公司 | Drug delivery medical device |
WO2014063111A1 (en) | 2012-10-18 | 2014-04-24 | Micell Technologyies, Inc. | Drug delivery medical device |
WO2013177211A1 (en) | 2012-05-21 | 2013-11-28 | Micell Technologies, Inc. | Safe drug eluting stent with absorbable coating |
WO2013173657A1 (en) | 2012-05-16 | 2013-11-21 | Micell Technologies, Inc. | Low burst sustained release lipophilic and biologic agent compositions |
KR20150143476A (en) | 2013-03-12 | 2015-12-23 | 미셀 테크놀로지즈, 인코포레이티드 | Bioabsorbable biomedical implants |
KR102079613B1 (en) | 2013-05-15 | 2020-02-20 | 미셀 테크놀로지즈, 인코포레이티드 | Bioabsorbable biomedical implants |
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WO2010121187A3 (en) | 2011-03-31 |
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EP2419058B1 (en) | 2018-02-28 |
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