CA2710583C - Compositions and devices - Google Patents
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- CA2710583C CA2710583C CA2710583A CA2710583A CA2710583C CA 2710583 C CA2710583 C CA 2710583C CA 2710583 A CA2710583 A CA 2710583A CA 2710583 A CA2710583 A CA 2710583A CA 2710583 C CA2710583 C CA 2710583C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention provides tooth-whitening compositions comprising a bleaching agent and a baste amino acid, together with devices for application thereof, and methods of use therefor.
Description
COMPOSITIONS AND DEVICES
BACKGROUND OF THE INVENTION
100011 Teeth whitening products are known in art, and include products and methods which are sold over the counter, or performed professionally. One bleaching device uses a tray which holds a bleaching composition and is then applied to the teeth. See e.g., US Patents 5,746,598 and 5,376,006. Another bleaching device is in the form of a strip which is applied to a tooth surface. See e.g., US Patent 5,891,453, 6,436,297, 5,879,691, 6,277,458, 5,894,071. Other bleaching devices are liquid tooth whitening gels as described in US Patent 6,669,930, US Publication 2005/0038181 and WO 2002/032961. While use of such devices may cause tooth whitening, they do not generally address treating the oral cavity for other indications. Indeed, such devices may also worsen some oral conditions. For example, people wearing such devices may tend to keep their mouths open, thereby causing increased evaporation of saliva resulting in dry mouth.
BACKGROUND OF THE INVENTION
100011 Teeth whitening products are known in art, and include products and methods which are sold over the counter, or performed professionally. One bleaching device uses a tray which holds a bleaching composition and is then applied to the teeth. See e.g., US Patents 5,746,598 and 5,376,006. Another bleaching device is in the form of a strip which is applied to a tooth surface. See e.g., US Patent 5,891,453, 6,436,297, 5,879,691, 6,277,458, 5,894,071. Other bleaching devices are liquid tooth whitening gels as described in US Patent 6,669,930, US Publication 2005/0038181 and WO 2002/032961. While use of such devices may cause tooth whitening, they do not generally address treating the oral cavity for other indications. Indeed, such devices may also worsen some oral conditions. For example, people wearing such devices may tend to keep their mouths open, thereby causing increased evaporation of saliva resulting in dry mouth.
[0002] While the use of such products may whiten teeth, there is a need to develop compositions which may simultaneously whiten teeth and treat the oral cavity, e.g., simultaneously reduce or inhibit formation of dental caries, reduce or inhibit demineralization and promote remineralization of the teeth, and/or treat dry mouth.
SUMMARY OF THE INVENTION
SUMMARY OF THE INVENTION
[0003] In one aspect, the invention relates to a composition comprising a dental whitening agent and arginine in salt form, wherein the dental whitening agent and the arginine in salt form are dispersed within a matrix material. In another aspect, the invention relates to a device for bleaching a patient's tooth comprising a delivery scaffold which is sized to cover a tooth surface to be bleached, said scaffold coated with a composition of the invention. In another aspect, the invention relates to use of arginine in salt form as an agent for combating cavity formation and tooth sensitivity in a dental whitening composition.
100041 The compositions of the present invention can promote or improve oral health and/or systemic health, including cardiovascular health, e.g., by reducing potential for systemic infection via the oral tissues.
100051 The present invention is directed to compositions and devices which deliver basic amino acids, e.g., arginine, to the oral cavity together with a whitening agent to whiten teeth, and, e.g., (i) reduce or inhibit formation of dental caries, (ii) reduce, repair or inhibit pre-carious lesions of the enamel, e.g., as detected by quantitative light-induced fluorescence (QLF) or electrical caries measurement (ECM), (iii) reduce or inhibit demineralization and promote remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or inhibit gingivitis, (vi) promote healing of sores or cuts in the mouth, (vii) reduce levels of acid producing bacteria, (viii) to increase relative levels of la arginolytic bacteria, (ix) inhibit microbial biofilm formation in the oral cavity, (x) raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge, (xi) reduce plaque accumulation, (xii) clean the teeth and oral cavity, (xiii) immunize the teeth against cariogenic bacteria, (xiv) promote systemic health, including cardiovascular health, e.g., by reducing potential for systemic infection via the oral tissues, (xv) reduce erosion and/or (xv) treat, relieve or reduce dry mouth. Such compositions and devices may be used alone, or in conjunction with other basic amino acid containing compositions, e.g., dentifrice compositions to deliver a basic amino acid to the oral cavity.
100061 Areinine and other basic amino acids have been proposed for use in.
oral care and are believed to have significant benefits in combating cavity formation and tooth sensitivity. it is believed that basic amino acids in the oral cavity are metabolized by certain types of bacteria, e.g., S. sanguis which are not cariogenic and which compete with cariogenic bacteria such as S. mutans, for position on the teeth and in the oral cavity. The arginolytic bacteria can use arginine and other basic amino acids to produce ammonia, thereby raising the pH of their environment, while cariogenic bacteria metabolize sugar to produce lactic acid, which tends to lower the plaque pH and demineralize the teeth, ultimately leading to cavities. Basic amino acids, e.g., arginine, moreover promote remineralization of the teeth, helping to repair erosion, and plugging rnicrotuhulcs implicated in dentinal sensitivity. Many patients complain of hypersensitive teeth followi.n.g bleaching treatments, possibly because the whitening chemicals irritate the nerve endings in the inicrotuhules.
100071 The present invention thus includes Composition 1.0, a dental bleaching composition comprising a. an effective amount of a dental whitening agent capable of bleaching tooth surfaces in contact with the dental whitening agent, and b. a basic amino acid in free or salt form.
1000811 The present invention also includes the following compositions:
1.1 Composition 1.0 wherein the basic amino acid is arginine, lysine, citrullene, ornithine, creatine, histidine, diammobutanoic acid, diarninoproprionic acid, salts thereof and/or combinations thereof.
1.2 Composition 1.0 or 1. 1 wherein the basic amino acid has the I,-configuration.
1.3 Any of the preceding compositions wherein the basic amino acid is arginine.
1.4 Any of the preceding compositions wherein the basic amino acid is 1, artnnine.
1.5 Any of the preceding compositions comprising a basic amino acid is in salt form.
1.6 Any of the preceding compositions comprising arginine phosphate.
1.7 Any of the preceding compositions comprising arginine hydrochloride.
1.8 Any of the preceding compositions comprising arginine percarbonate.
1.9 Any of the preceding compositions comprising arginine bicarbonate.
1.10 Any of the preceding compositions comprising from about 0.1% to about 50% by weight of the basic amino acid.
1.11 Any of the preceding compositions further comprising a matrix material.
1.12 Any of the preceding compositions wherein the dental whitening agent and basic amino acid is dispersed within the matrix material.
1.13 Any of the preceding compositions further comprising carboxypolymethyl.ene.
1.14 Any of the preceding compositions further comprising a matrix material comprising reaction products of carboxypolymethylene, 1.15 Any of the preceding compositions comprising polyvinylpyrrolidone.
1.16 Any of the preceding compositions further comprising a matrix material.
having a stickiness and/or resistance to dilution by saliva such that when the dental composition is placed within a dental tray and the dental tray is positioned over the teeth the dental composition will retain the dental tray in position over the teeth, e.g., for at least about 1, 2, 3, 4, or 5 hours without significant pressure exerted by the dental tray.
1.17 Any of the preceding compositions further comprising water.
118 Any of the preceding compositions further comprising glycerine.
1.19 Any of the preceding compositions further comprising polyethylene glycol.
1.20 Any of the preceding compositions having a pH of about 5 to about 12.
1.21 Any of the preceding compositions having a pH of about 6.1.
1.22 Any of the preceding compositions wherein the dental whitening agent is selected from. the group consisting of peroxides, metal chlorites, perborates, percarbona.tes, peroxyacids, hypochlorites, and combinations thereof 1.23 Any of the preceding compositions wherein the whitening agent is hydrogen peroxide or a hydrogen peroxide source, e.g., urea peroxide or a peroxide salt or complex (e.g., such as peroxyphosphate, peroxycarbonate, perhorate, peroxysilicate, or persulphate salts; for example calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, and potassium persulfate), or hydrogen peroxide polymer complexes such as hydrogen peroxide polyvinyl pyrrolidone polymer complexes.
1.24 Any of the preceding compositions comprising carbamide peroxide, sodium perborate, sodium percarbonate, and/or hydrogen peroxide.
1.25 Any of the preceding compositions wherein the pH is adjusted with a base selected from triethanolamine, sodium hydroxide, or a basic amino acid.
1.26 Composition 1.25 wherein the basic amino acid is arginine, lysine, citruIlene, ornithin.e, creatine, histidine, diaminobutanoic acid, diaminoproprion.ic acid, salts thereof andlor combinations thereof.
1.27 Composition 1.25 or 1.26 wherein the basic amino acid is in free or salt form selected from the hydroxide, hydrochloride, bicarbonate, phosphate, and/or combinations thereof.
1.28 Composition L27 wherein the basic amino acid is selected from arginine bicarbonate and arginine hydroxide.
1.29 Any of the preceding compositions further comprising a fluoride salt selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations
100041 The compositions of the present invention can promote or improve oral health and/or systemic health, including cardiovascular health, e.g., by reducing potential for systemic infection via the oral tissues.
100051 The present invention is directed to compositions and devices which deliver basic amino acids, e.g., arginine, to the oral cavity together with a whitening agent to whiten teeth, and, e.g., (i) reduce or inhibit formation of dental caries, (ii) reduce, repair or inhibit pre-carious lesions of the enamel, e.g., as detected by quantitative light-induced fluorescence (QLF) or electrical caries measurement (ECM), (iii) reduce or inhibit demineralization and promote remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or inhibit gingivitis, (vi) promote healing of sores or cuts in the mouth, (vii) reduce levels of acid producing bacteria, (viii) to increase relative levels of la arginolytic bacteria, (ix) inhibit microbial biofilm formation in the oral cavity, (x) raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge, (xi) reduce plaque accumulation, (xii) clean the teeth and oral cavity, (xiii) immunize the teeth against cariogenic bacteria, (xiv) promote systemic health, including cardiovascular health, e.g., by reducing potential for systemic infection via the oral tissues, (xv) reduce erosion and/or (xv) treat, relieve or reduce dry mouth. Such compositions and devices may be used alone, or in conjunction with other basic amino acid containing compositions, e.g., dentifrice compositions to deliver a basic amino acid to the oral cavity.
100061 Areinine and other basic amino acids have been proposed for use in.
oral care and are believed to have significant benefits in combating cavity formation and tooth sensitivity. it is believed that basic amino acids in the oral cavity are metabolized by certain types of bacteria, e.g., S. sanguis which are not cariogenic and which compete with cariogenic bacteria such as S. mutans, for position on the teeth and in the oral cavity. The arginolytic bacteria can use arginine and other basic amino acids to produce ammonia, thereby raising the pH of their environment, while cariogenic bacteria metabolize sugar to produce lactic acid, which tends to lower the plaque pH and demineralize the teeth, ultimately leading to cavities. Basic amino acids, e.g., arginine, moreover promote remineralization of the teeth, helping to repair erosion, and plugging rnicrotuhulcs implicated in dentinal sensitivity. Many patients complain of hypersensitive teeth followi.n.g bleaching treatments, possibly because the whitening chemicals irritate the nerve endings in the inicrotuhules.
100071 The present invention thus includes Composition 1.0, a dental bleaching composition comprising a. an effective amount of a dental whitening agent capable of bleaching tooth surfaces in contact with the dental whitening agent, and b. a basic amino acid in free or salt form.
1000811 The present invention also includes the following compositions:
1.1 Composition 1.0 wherein the basic amino acid is arginine, lysine, citrullene, ornithine, creatine, histidine, diammobutanoic acid, diarninoproprionic acid, salts thereof and/or combinations thereof.
1.2 Composition 1.0 or 1. 1 wherein the basic amino acid has the I,-configuration.
1.3 Any of the preceding compositions wherein the basic amino acid is arginine.
1.4 Any of the preceding compositions wherein the basic amino acid is 1, artnnine.
1.5 Any of the preceding compositions comprising a basic amino acid is in salt form.
1.6 Any of the preceding compositions comprising arginine phosphate.
1.7 Any of the preceding compositions comprising arginine hydrochloride.
1.8 Any of the preceding compositions comprising arginine percarbonate.
1.9 Any of the preceding compositions comprising arginine bicarbonate.
1.10 Any of the preceding compositions comprising from about 0.1% to about 50% by weight of the basic amino acid.
1.11 Any of the preceding compositions further comprising a matrix material.
1.12 Any of the preceding compositions wherein the dental whitening agent and basic amino acid is dispersed within the matrix material.
1.13 Any of the preceding compositions further comprising carboxypolymethyl.ene.
1.14 Any of the preceding compositions further comprising a matrix material comprising reaction products of carboxypolymethylene, 1.15 Any of the preceding compositions comprising polyvinylpyrrolidone.
1.16 Any of the preceding compositions further comprising a matrix material.
having a stickiness and/or resistance to dilution by saliva such that when the dental composition is placed within a dental tray and the dental tray is positioned over the teeth the dental composition will retain the dental tray in position over the teeth, e.g., for at least about 1, 2, 3, 4, or 5 hours without significant pressure exerted by the dental tray.
1.17 Any of the preceding compositions further comprising water.
118 Any of the preceding compositions further comprising glycerine.
1.19 Any of the preceding compositions further comprising polyethylene glycol.
1.20 Any of the preceding compositions having a pH of about 5 to about 12.
1.21 Any of the preceding compositions having a pH of about 6.1.
1.22 Any of the preceding compositions wherein the dental whitening agent is selected from. the group consisting of peroxides, metal chlorites, perborates, percarbona.tes, peroxyacids, hypochlorites, and combinations thereof 1.23 Any of the preceding compositions wherein the whitening agent is hydrogen peroxide or a hydrogen peroxide source, e.g., urea peroxide or a peroxide salt or complex (e.g., such as peroxyphosphate, peroxycarbonate, perhorate, peroxysilicate, or persulphate salts; for example calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, and potassium persulfate), or hydrogen peroxide polymer complexes such as hydrogen peroxide polyvinyl pyrrolidone polymer complexes.
1.24 Any of the preceding compositions comprising carbamide peroxide, sodium perborate, sodium percarbonate, and/or hydrogen peroxide.
1.25 Any of the preceding compositions wherein the pH is adjusted with a base selected from triethanolamine, sodium hydroxide, or a basic amino acid.
1.26 Composition 1.25 wherein the basic amino acid is arginine, lysine, citruIlene, ornithin.e, creatine, histidine, diaminobutanoic acid, diaminoproprion.ic acid, salts thereof andlor combinations thereof.
1.27 Composition 1.25 or 1.26 wherein the basic amino acid is in free or salt form selected from the hydroxide, hydrochloride, bicarbonate, phosphate, and/or combinations thereof.
1.28 Composition L27 wherein the basic amino acid is selected from arginine bicarbonate and arginine hydroxide.
1.29 Any of the preceding compositions further comprising a fluoride salt selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations
4 thereof.
1.30 Any of the preceding compositions comprising an antibacterial agent selected from halogenated diphenyl ether (e.g. triclosan), herbal extracts and essential oils (e.g., rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinokitol, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin, gall.ic acid, niswak extract, sea-buckthorn extract), bisguanide antiseptics (e.g., chlorhexidine, alexidine or octenidi.ne), quaternary ammonium compounds (e.g., cetylpyridinium chloride (CPC), benzalkonium chloride, tetradecylpyridinium chloride (TPC), N-tetradecy1-4-ethylpyTidinium chloride (IDEPC)), phenolic antiseptics, hexetidine, octenidine, sanguinarine, povidone iodine, delmopinol, salifluor, metal ions (e.g., zinc salts, for example, zinc citrate, stannous salts, copper salts, iron salts), sanguinarine, propolis and oxygenating agents (e.g., hydrogen peroxide, buffered sodium peroxyborate or peroxycarbonate), phthalic acid and its salts, monoperthalic acid and its salts and esters, ascorbyl stearate, oleoyl sarcosine, alkyl sulfate, dioetyl sulfosuccinate, salicylanilide, dorniphen bromide, delmopinol, octapinol and other piperidino derivatives, niein preparations, chlorite salts; and mixtures of any of the foregoing.
1.31 Any of the preceding compositions which is a gel.
100091 Another embodiment of the present invention is a method for bleaching a patient's tooth comprising applying any one of compositions 1.0 - 1.31 to a tooth, e.g., as a film.
The composition may be allowed to dry, and the dried composition is allowed to adhere to the tooth, e.g., for 1 to 30 minutes before falling or eroding off the tooth surface.
100101 Another embodiment of the present invention includes a method for bleaching a patient's tooth comprising a delivery scaffold which is sized to cover a tooth. surface to be bleached coated with any one of compositions 1.0 1.31, positioning the scaffold over the tooth such that at least a portion of composition 1.0 1.31 is in contact with the tooth surface to be bleached, allowing the tray to remain in position over the tooth for at least one hour, and removing the tray from the tooth. The delivery scaffold may be in the form of a tray, wherein the tray is configured to hold a quantity of any one of compositions 1.0 1.31. The delivery scaffold may also be in the form of a strip, e.g., flexible strip wherein compositions 1.0 ---- 131 form a film on one side of the strip to be applied to the tooth. In another embodiment, the delivery scaffold may be sized to cover more than one tooth.
10011] Other embodiments of the present invention will be apparent to one of skill in the art.
DETAILED DESCRIPTION OF THE INVENTION
100121 An "effective amount" is an amount that is sufficient to have a desired therapeutic or prophylactic effect in the oral cavity without undue adverse side effects such as irritation or allergic response.
100131 Unless otherwise indicated, as used herein, a basic amino acid includes a basic amino acid in free base or salt form.
100141 Dental whitening agents are known in the art, and include any material safe for use in the oral cavity which provides bleaching or stain removal. Suitable agents are peroxides, metal chlorites, perborates, percarbonates, peroxyaeids, and combinations thereof. Suitable peroxide compounds include hydrogen peroxide, calcium peroxide, carbamide peroxide, and mixtures thereof. Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, sodium chlorite, and potassium chlorite. Suitable hydrogen peroxide sources include, e.g., urea peroxide or a peroxide salt or complex (e.g., such as peroxyphosphate, peroxycarbonate, perborate, peroxysilicate, or persulphate salts; for example calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, and potassium persulfate), or hydrogen peroxide polymer complexes such as hydrogen peroxide-polyvinyl pyrrolidone polymer complexes. Effective concentrations of dental whitening agents are also known in th.e art, as are effective treatment times.
100151 The basic amino acids which can be used in the compositions of the present the invention include not only naturally occurring basic amino acids, such as arginine, lysine, and histidine, but also any basic amino acids having a carboxyl group and an amino group in the molecule. Accordingly, basic amino acids include, but are not limited to, arginine, lysine, citrullene, omithine, creatine, histidine, diarninabutanoic acid, diamirtoproprionic acid, salts thereof or combinations thereof. In a particular embodiment, the basic amino acids are selected from arginine, citnillene, and omithin.e, preferably, arginine, for example, 1-arginine.
100161 As used herein, reference to a basic amino acid also includes salts thereof As the compositions and devices of the invention are intended thr use in the mouth, salts for use in the present invention should be safe for such use, in the amounts and concentrations provided. Suitable salts include salts known in the art to be pharmaceutically acceptable salts are generally considered to be physiologically acceptable in the amounts and concentrations provided. Physiologically acceptable salts include those derived from pharmaceutically acceptable inorganic or organic acids or bases, for example acid addition salts formed by acids which form a physiological acceptable anion, e.g., hydrochloride or bromide salt, and base addition salts formed by bases which form a physiologically acceptable cation, for example those derived from alkali metals such as potassium and sodium or alkaline earth metals such as calcium and magnesium. Physiologically acceptable salts may be obtained using standard procedures known in the art, for example, by reacting a sufficiently basic compound such as an amine with a suitable acid affording a physiologically acceptable anion, 100171 The compositions of the present invention comprise an effective amount of a basic amino acid. Thus, the composition may comprise from about 1 t4 to about 50% by weight of a basic amino acid, e.g., about 1, 2, 3,4, 5, 10, 15, 20, 25, 30, 35, 40 or 45%.
[00181 The compositions of the present invention may optionally be suspended in a matrix.
Suitable matrix materials are safe for use in the oral cavity, and do not readily dissolve in the oral cavity, and do not react with the dental whitening agent or basic amino acid.
100191 Matrix materials are known in the art, and are generally water swellable polymers, such as carboxypolymethylene, carboxymethyl cellulose, carboxypropyi cellulose, poloxamer, carrageenan, Veegum, carboxyvinyl polymers, polyvinylpyrrolidone, and natural gums such as gum karaya, xanthan gum, Guar gum, gum arabic, gum tragacanth., and mixtures thereof.
[00201 One preferred matrix material is carboxypolymethylene. It has been previously deter mined that supersaturated carboxypolymethylene water compositions having a carboxypolyethylen.e concentration of from about 3.5% to about 12% have a high viscosity, and sustained release dental compositions may be prepared from it. As the compositions of the present invention may have non-aqueous or water insoluble components, the concentration of carboxypolymethylene may be higher, e.g., from about 15% to about 35%.
[00211 Carboxypolymethylene may be available from various sources, including from B.F.
Goodrich Company under the trade name CARBOPOL, such as CA.RBOPOL 934P and CA.RBOPOL, 940.
[00221 It has been found that carboxypolymethylene may be mixed with glycerine to enable large quantities of carboxypolymethylene to be dispersed in water. The amounts of glycerine in such compositions is known in the art, e.g., from about 20% to about 70% by weight. Glycerine may optionally be substituted with polypropylene, sorbitol, polyethylene glycols, or other polyols.
100231 The presence of carboxypolytnethylene may lower the pH of the compositions of the present invention. To prevent low pH's which may erode dental enamel and to take advantage of the benefits of the basic amino acid, compositions of the present invention may have a pH in the range of from about 5 to 12, e.g., about 5.5 to about 6.5, e.g., about 6.1.
The pH of the compositions may be adjusted with any base known in the art to be physiologically acceptable at the intended final Concentrations, e.g., sodium hydroxide or triethanolamine, or with a basic amino acid or salt thereof.
100241 Another preferred matrix is polyvinylpyrrolidone, see US Pat No.
6,730,316.
100251 Preferably, the basic amino acid and any other ingredients are evenly distributed in the =matrix, even if such materials are insoluble in the matrix.
100261 The compositions of the present invention are suitable for directly applying to one or more teeth, e.g.. as a thin film. The film is allowed to adhere to the tooth, and is maintained on the tooth surface for 1 to 30 minutes before falling or eroding off.
[0027] The compositions of the present invention may be applied to one of more teeth by a delivery scaffold, such as a tray or a strip, both of which are known in the art.
10028j Where the delivery scaffold is a dental tray, the tray is configured to hold a quantity of any one of compositions of the present invention, e.g., from about .5 to about 5 ml.
Dental trays are known in the art, as are their methods of manufacture.
Generally, the dental tray is shaped to be able to fit in a wearer's mouth, and a channel adapted to fit over one or more teeth. Compositions of the present invention are generally dispensed into the channel, and then the dental tray is adhered to the teeth.
100291 Where the delivery scaffold is a strip, the tooth whitening compositions of the present invention may be applied or coated onto the strip. Such dental strips are known in the art, as are method.s for their manufacture. Strips generally have a flexibility and stiffness which enables them to bend and conform to form a curved shape around one tooth or a plurality of adjacent teeth. The strip may also have shallow pockets to provide a reservoir of the bleaching composition. Generally, the viscous and adhesive nature of the beaching composition allows for the strip to be reversibly attached to one or adjacent teeth. However, the adhesiveness is low enough to allow the strip to be easily removed by the wearer by pulling off the strip of material.
[00301 In one embodiment of the present invention, the compositions may optionally include an effective amount of fluoride, or a fluoride ion source, e.g., soluble fluoride salts.
A wide variety of fluoride ion-yielding materials can be employed as sources of soluble fluoride in the present compositions. Examples of suitable fluoride ion-yielding materials are found in U.S. Pat. No. 3,535,421, to Briner et al.; U.S. Pat. No.
4,885,155, to Panan, Jr.
et al. and U.S. Pat. No. 3,678,154.
100311 Representative fluoride ion sources include, but are not limited to, stannous .fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.
In certain embodiments the fluoride ion source includes stannous fluoride, sodium fluoride, sodium monofluorophosphate as well as mixtures thereof.
100321 In certain embodiments, the oral care composition of the invention may also contain a source of fluoride ions or fluorine-providing ingredient in amounts sufficient to supply about 25 ppm to 25,000 ppm of fluoride ions, generally at least about 500 ppm, e.g., about 500 to about 2000 ppm, e.g., about 1000 to about 1600 ppm, e.g., about 1450 ppm. The appropriate level of fluoride will depend on the particular application. A
mouthwash, for example, would typically have about 100 to about 250 ppm fluoride. A
toothpaste for general consumer use would typically have about 1000 to about 1500 ppm. with pediatric toothpaste having somewhat less. A dentifrice or coating for professional application could have as much as 5,000 or even 25,000 ppm fluoride.
100331 Fluoride ion sources may be added to the compositions of the invention at a level of about 0.01 wt. % to about 10 wt. % in one embodiment or about 0.03 wt. % to about 5 wt.
Jo'. and in another embodiment about 0.1 wt. % to about 1 wt. by weight of the composition in another embodiment. Weights of fluoride salts to provide the appropriate level of fluoride ion will obviously vary based on the weight of the counter ion in the salt 100341 In another embodiment of the present invention, the compositions may optionally comprise an antiseptic, antimicrobial or antibacterial agent, the agent being selected from halogenated diphenyi ether (e.g. trklosan). herbal extracts and essential oils (e.g., rosematy extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, gcraniol, carvacrol, dim!, hinokitol, catechol, methyl salicylate. epigallocatechin .gallate.
epigallocatechin, gailic acid.
miswak extract, sea-buckthorn extract), bisguanide antiseptics (e.g., chlorhexidine, alexidine or octenidine), quaternary ammonium compounds (e.g., cetylpyridin.ium chloride (CPC), benzalkonium chloride, tetradecylp,yridinium chloride (TPC), N-tetradecy1-4-ethylpyridinium chloride (TDEPC)), phenolic antiseptics, hexetidine, octenidine, sanguinarine, povidone iodine, delmopinol, salifluor, metal ions (e.a., zinc salts, for example, zinc citrate, stannous salts, copper salts, iron salts), sang,uinarine, propolis and oxygenating agents (e.g., hydrogen peroxide, buffered sodium peroxyborate or peroxycarbonate), phthalic acid and its salts, monoperthalic acid and its salts and esters, ascorbyl stearate, oleoyi sarcosine, alkyl sulfate, dioctyl sulfosuccinate, salicylanilicle, d.omiphen bromide, clehnopinol, oetapinol and other piperidino derivatives, nicin preparations, chlorite salts; and mixtures of any of the foregoing, to further aid in the beneficial effects of the basic amino acid.
100351 The compositions may further comprise an agent that interferes with or prevents bacterial attachment, e.g., solbrol or chitosan [0036] In another embodiment of the present invention, the compositions may optimally comprise anti-inflammatory agents, such as non-steroid anti-inflammatory drugs.
100371 The compositions of the present invention may also include flavors.
Flavoring agents which are used in the practice of the present invention include, but are not limited to, essential oils as well as various flavoring aldehydes, esters, alcohols, and similar materials.
Examples of the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit. and orange. Also useful arc such chemicals as menthol, carvone, and anethole. Useful flavorings may also include sweeteners, such as sucralose, aspartaine, saccharine. The compositions of the present invention may also include colors.
100381 Enhancing oral health also provides benefits in systemic health, as the oral tissues can be gateways for systemic infections. Good oral health is associated with systemic health, including cardiovascular health. The compositions and methods of the invention provide particular benefits because basic amino acids, especially arginine, are sources of nitrogen which supply NO synthesis pathways and thus enhance microcirculation in the oral tissues. Providing a less acidic oral environment is also helpful in reducing gastric distress and creates an environment less favorable to Heliobacter, which is associated with gastric ulcers. Argini.ne in particular is required for high expression of specific immune cell receptors, for example T-cell receptors, so that arginine can enhance an effective immune response. The compositions and methods of the invention are thus useful to enhance systemic health, including cardiovascular health.
100391 As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the ramie can be selected as the terminus of the range.
In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls. it is understood that when formulations are described, they may be described in terms of their ingredients, as is common in the art, notwithstanding that these ingredients may react with one another in the actual formulation as it is made, stored and used, and such products are intended to be covered by the formulations described.
100401 The following examples further describe and demonstrate illustrative embodiments within the scope of the present invention. The examples are given solely for illustration and are not to be construed as limitations of this invention as many variations are possible without departing from the scope thereof. Various modifications of the invention in addition to those shown and described herein should be apparent to those skilled in the art.
and are intended to fall within the appended claims.
100411 A dental bleaching composition is prepared by combining the following ingredients:
Dental whitening agent 10%
Basic amino acid 50%
Water 40%
100421 25 grams of L-arginine is added to 50 grams of water to form a slurry.
1.30 Any of the preceding compositions comprising an antibacterial agent selected from halogenated diphenyl ether (e.g. triclosan), herbal extracts and essential oils (e.g., rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinokitol, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin, gall.ic acid, niswak extract, sea-buckthorn extract), bisguanide antiseptics (e.g., chlorhexidine, alexidine or octenidi.ne), quaternary ammonium compounds (e.g., cetylpyridinium chloride (CPC), benzalkonium chloride, tetradecylpyridinium chloride (TPC), N-tetradecy1-4-ethylpyTidinium chloride (IDEPC)), phenolic antiseptics, hexetidine, octenidine, sanguinarine, povidone iodine, delmopinol, salifluor, metal ions (e.g., zinc salts, for example, zinc citrate, stannous salts, copper salts, iron salts), sanguinarine, propolis and oxygenating agents (e.g., hydrogen peroxide, buffered sodium peroxyborate or peroxycarbonate), phthalic acid and its salts, monoperthalic acid and its salts and esters, ascorbyl stearate, oleoyl sarcosine, alkyl sulfate, dioetyl sulfosuccinate, salicylanilide, dorniphen bromide, delmopinol, octapinol and other piperidino derivatives, niein preparations, chlorite salts; and mixtures of any of the foregoing.
1.31 Any of the preceding compositions which is a gel.
100091 Another embodiment of the present invention is a method for bleaching a patient's tooth comprising applying any one of compositions 1.0 - 1.31 to a tooth, e.g., as a film.
The composition may be allowed to dry, and the dried composition is allowed to adhere to the tooth, e.g., for 1 to 30 minutes before falling or eroding off the tooth surface.
100101 Another embodiment of the present invention includes a method for bleaching a patient's tooth comprising a delivery scaffold which is sized to cover a tooth. surface to be bleached coated with any one of compositions 1.0 1.31, positioning the scaffold over the tooth such that at least a portion of composition 1.0 1.31 is in contact with the tooth surface to be bleached, allowing the tray to remain in position over the tooth for at least one hour, and removing the tray from the tooth. The delivery scaffold may be in the form of a tray, wherein the tray is configured to hold a quantity of any one of compositions 1.0 1.31. The delivery scaffold may also be in the form of a strip, e.g., flexible strip wherein compositions 1.0 ---- 131 form a film on one side of the strip to be applied to the tooth. In another embodiment, the delivery scaffold may be sized to cover more than one tooth.
10011] Other embodiments of the present invention will be apparent to one of skill in the art.
DETAILED DESCRIPTION OF THE INVENTION
100121 An "effective amount" is an amount that is sufficient to have a desired therapeutic or prophylactic effect in the oral cavity without undue adverse side effects such as irritation or allergic response.
100131 Unless otherwise indicated, as used herein, a basic amino acid includes a basic amino acid in free base or salt form.
100141 Dental whitening agents are known in the art, and include any material safe for use in the oral cavity which provides bleaching or stain removal. Suitable agents are peroxides, metal chlorites, perborates, percarbonates, peroxyaeids, and combinations thereof. Suitable peroxide compounds include hydrogen peroxide, calcium peroxide, carbamide peroxide, and mixtures thereof. Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, sodium chlorite, and potassium chlorite. Suitable hydrogen peroxide sources include, e.g., urea peroxide or a peroxide salt or complex (e.g., such as peroxyphosphate, peroxycarbonate, perborate, peroxysilicate, or persulphate salts; for example calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, and potassium persulfate), or hydrogen peroxide polymer complexes such as hydrogen peroxide-polyvinyl pyrrolidone polymer complexes. Effective concentrations of dental whitening agents are also known in th.e art, as are effective treatment times.
100151 The basic amino acids which can be used in the compositions of the present the invention include not only naturally occurring basic amino acids, such as arginine, lysine, and histidine, but also any basic amino acids having a carboxyl group and an amino group in the molecule. Accordingly, basic amino acids include, but are not limited to, arginine, lysine, citrullene, omithine, creatine, histidine, diarninabutanoic acid, diamirtoproprionic acid, salts thereof or combinations thereof. In a particular embodiment, the basic amino acids are selected from arginine, citnillene, and omithin.e, preferably, arginine, for example, 1-arginine.
100161 As used herein, reference to a basic amino acid also includes salts thereof As the compositions and devices of the invention are intended thr use in the mouth, salts for use in the present invention should be safe for such use, in the amounts and concentrations provided. Suitable salts include salts known in the art to be pharmaceutically acceptable salts are generally considered to be physiologically acceptable in the amounts and concentrations provided. Physiologically acceptable salts include those derived from pharmaceutically acceptable inorganic or organic acids or bases, for example acid addition salts formed by acids which form a physiological acceptable anion, e.g., hydrochloride or bromide salt, and base addition salts formed by bases which form a physiologically acceptable cation, for example those derived from alkali metals such as potassium and sodium or alkaline earth metals such as calcium and magnesium. Physiologically acceptable salts may be obtained using standard procedures known in the art, for example, by reacting a sufficiently basic compound such as an amine with a suitable acid affording a physiologically acceptable anion, 100171 The compositions of the present invention comprise an effective amount of a basic amino acid. Thus, the composition may comprise from about 1 t4 to about 50% by weight of a basic amino acid, e.g., about 1, 2, 3,4, 5, 10, 15, 20, 25, 30, 35, 40 or 45%.
[00181 The compositions of the present invention may optionally be suspended in a matrix.
Suitable matrix materials are safe for use in the oral cavity, and do not readily dissolve in the oral cavity, and do not react with the dental whitening agent or basic amino acid.
100191 Matrix materials are known in the art, and are generally water swellable polymers, such as carboxypolymethylene, carboxymethyl cellulose, carboxypropyi cellulose, poloxamer, carrageenan, Veegum, carboxyvinyl polymers, polyvinylpyrrolidone, and natural gums such as gum karaya, xanthan gum, Guar gum, gum arabic, gum tragacanth., and mixtures thereof.
[00201 One preferred matrix material is carboxypolymethylene. It has been previously deter mined that supersaturated carboxypolymethylene water compositions having a carboxypolyethylen.e concentration of from about 3.5% to about 12% have a high viscosity, and sustained release dental compositions may be prepared from it. As the compositions of the present invention may have non-aqueous or water insoluble components, the concentration of carboxypolymethylene may be higher, e.g., from about 15% to about 35%.
[00211 Carboxypolymethylene may be available from various sources, including from B.F.
Goodrich Company under the trade name CARBOPOL, such as CA.RBOPOL 934P and CA.RBOPOL, 940.
[00221 It has been found that carboxypolymethylene may be mixed with glycerine to enable large quantities of carboxypolymethylene to be dispersed in water. The amounts of glycerine in such compositions is known in the art, e.g., from about 20% to about 70% by weight. Glycerine may optionally be substituted with polypropylene, sorbitol, polyethylene glycols, or other polyols.
100231 The presence of carboxypolytnethylene may lower the pH of the compositions of the present invention. To prevent low pH's which may erode dental enamel and to take advantage of the benefits of the basic amino acid, compositions of the present invention may have a pH in the range of from about 5 to 12, e.g., about 5.5 to about 6.5, e.g., about 6.1.
The pH of the compositions may be adjusted with any base known in the art to be physiologically acceptable at the intended final Concentrations, e.g., sodium hydroxide or triethanolamine, or with a basic amino acid or salt thereof.
100241 Another preferred matrix is polyvinylpyrrolidone, see US Pat No.
6,730,316.
100251 Preferably, the basic amino acid and any other ingredients are evenly distributed in the =matrix, even if such materials are insoluble in the matrix.
100261 The compositions of the present invention are suitable for directly applying to one or more teeth, e.g.. as a thin film. The film is allowed to adhere to the tooth, and is maintained on the tooth surface for 1 to 30 minutes before falling or eroding off.
[0027] The compositions of the present invention may be applied to one of more teeth by a delivery scaffold, such as a tray or a strip, both of which are known in the art.
10028j Where the delivery scaffold is a dental tray, the tray is configured to hold a quantity of any one of compositions of the present invention, e.g., from about .5 to about 5 ml.
Dental trays are known in the art, as are their methods of manufacture.
Generally, the dental tray is shaped to be able to fit in a wearer's mouth, and a channel adapted to fit over one or more teeth. Compositions of the present invention are generally dispensed into the channel, and then the dental tray is adhered to the teeth.
100291 Where the delivery scaffold is a strip, the tooth whitening compositions of the present invention may be applied or coated onto the strip. Such dental strips are known in the art, as are method.s for their manufacture. Strips generally have a flexibility and stiffness which enables them to bend and conform to form a curved shape around one tooth or a plurality of adjacent teeth. The strip may also have shallow pockets to provide a reservoir of the bleaching composition. Generally, the viscous and adhesive nature of the beaching composition allows for the strip to be reversibly attached to one or adjacent teeth. However, the adhesiveness is low enough to allow the strip to be easily removed by the wearer by pulling off the strip of material.
[00301 In one embodiment of the present invention, the compositions may optionally include an effective amount of fluoride, or a fluoride ion source, e.g., soluble fluoride salts.
A wide variety of fluoride ion-yielding materials can be employed as sources of soluble fluoride in the present compositions. Examples of suitable fluoride ion-yielding materials are found in U.S. Pat. No. 3,535,421, to Briner et al.; U.S. Pat. No.
4,885,155, to Panan, Jr.
et al. and U.S. Pat. No. 3,678,154.
100311 Representative fluoride ion sources include, but are not limited to, stannous .fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.
In certain embodiments the fluoride ion source includes stannous fluoride, sodium fluoride, sodium monofluorophosphate as well as mixtures thereof.
100321 In certain embodiments, the oral care composition of the invention may also contain a source of fluoride ions or fluorine-providing ingredient in amounts sufficient to supply about 25 ppm to 25,000 ppm of fluoride ions, generally at least about 500 ppm, e.g., about 500 to about 2000 ppm, e.g., about 1000 to about 1600 ppm, e.g., about 1450 ppm. The appropriate level of fluoride will depend on the particular application. A
mouthwash, for example, would typically have about 100 to about 250 ppm fluoride. A
toothpaste for general consumer use would typically have about 1000 to about 1500 ppm. with pediatric toothpaste having somewhat less. A dentifrice or coating for professional application could have as much as 5,000 or even 25,000 ppm fluoride.
100331 Fluoride ion sources may be added to the compositions of the invention at a level of about 0.01 wt. % to about 10 wt. % in one embodiment or about 0.03 wt. % to about 5 wt.
Jo'. and in another embodiment about 0.1 wt. % to about 1 wt. by weight of the composition in another embodiment. Weights of fluoride salts to provide the appropriate level of fluoride ion will obviously vary based on the weight of the counter ion in the salt 100341 In another embodiment of the present invention, the compositions may optionally comprise an antiseptic, antimicrobial or antibacterial agent, the agent being selected from halogenated diphenyi ether (e.g. trklosan). herbal extracts and essential oils (e.g., rosematy extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, gcraniol, carvacrol, dim!, hinokitol, catechol, methyl salicylate. epigallocatechin .gallate.
epigallocatechin, gailic acid.
miswak extract, sea-buckthorn extract), bisguanide antiseptics (e.g., chlorhexidine, alexidine or octenidine), quaternary ammonium compounds (e.g., cetylpyridin.ium chloride (CPC), benzalkonium chloride, tetradecylp,yridinium chloride (TPC), N-tetradecy1-4-ethylpyridinium chloride (TDEPC)), phenolic antiseptics, hexetidine, octenidine, sanguinarine, povidone iodine, delmopinol, salifluor, metal ions (e.a., zinc salts, for example, zinc citrate, stannous salts, copper salts, iron salts), sang,uinarine, propolis and oxygenating agents (e.g., hydrogen peroxide, buffered sodium peroxyborate or peroxycarbonate), phthalic acid and its salts, monoperthalic acid and its salts and esters, ascorbyl stearate, oleoyi sarcosine, alkyl sulfate, dioctyl sulfosuccinate, salicylanilicle, d.omiphen bromide, clehnopinol, oetapinol and other piperidino derivatives, nicin preparations, chlorite salts; and mixtures of any of the foregoing, to further aid in the beneficial effects of the basic amino acid.
100351 The compositions may further comprise an agent that interferes with or prevents bacterial attachment, e.g., solbrol or chitosan [0036] In another embodiment of the present invention, the compositions may optimally comprise anti-inflammatory agents, such as non-steroid anti-inflammatory drugs.
100371 The compositions of the present invention may also include flavors.
Flavoring agents which are used in the practice of the present invention include, but are not limited to, essential oils as well as various flavoring aldehydes, esters, alcohols, and similar materials.
Examples of the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit. and orange. Also useful arc such chemicals as menthol, carvone, and anethole. Useful flavorings may also include sweeteners, such as sucralose, aspartaine, saccharine. The compositions of the present invention may also include colors.
100381 Enhancing oral health also provides benefits in systemic health, as the oral tissues can be gateways for systemic infections. Good oral health is associated with systemic health, including cardiovascular health. The compositions and methods of the invention provide particular benefits because basic amino acids, especially arginine, are sources of nitrogen which supply NO synthesis pathways and thus enhance microcirculation in the oral tissues. Providing a less acidic oral environment is also helpful in reducing gastric distress and creates an environment less favorable to Heliobacter, which is associated with gastric ulcers. Argini.ne in particular is required for high expression of specific immune cell receptors, for example T-cell receptors, so that arginine can enhance an effective immune response. The compositions and methods of the invention are thus useful to enhance systemic health, including cardiovascular health.
100391 As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the ramie can be selected as the terminus of the range.
In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls. it is understood that when formulations are described, they may be described in terms of their ingredients, as is common in the art, notwithstanding that these ingredients may react with one another in the actual formulation as it is made, stored and used, and such products are intended to be covered by the formulations described.
100401 The following examples further describe and demonstrate illustrative embodiments within the scope of the present invention. The examples are given solely for illustration and are not to be construed as limitations of this invention as many variations are possible without departing from the scope thereof. Various modifications of the invention in addition to those shown and described herein should be apparent to those skilled in the art.
and are intended to fall within the appended claims.
100411 A dental bleaching composition is prepared by combining the following ingredients:
Dental whitening agent 10%
Basic amino acid 50%
Water 40%
100421 25 grams of L-arginine is added to 50 grams of water to form a slurry.
5 tifams of a 10-6 carbamide peroxide solution is added to the slurry, and the slurry is applied to an extracted tooth in vitro. The composition is rinsed away following 2 hours of treatment, and the tooth appears to be whiter in color when compared to a shade guide.
EXAMPI.F. 3 100431 25 grams of L-arginine bicarbonate is added to 50 grams of water to form a solution.
II
gams of a 10% carbamide peroxide solution is added to the solution, and a stained extracted tooth from a smoker (approximately 25 cigarettes per day, without visiting a dental hygienist for 5 months) is immersed therein in vitro. The composition is rinsed away following 2 hours of treatment, and the tooth appears to be whiter in color when compared to a shade guide.
100441 A dental bleaching composition is prepared by combining the following ingredients Carbamide peroxide 10%
Water 21%
Glycerine 57%
CARBOPOL 934P 7%
L-arginine 5%
100451 The composition of EXAMPLE 4 is adjusted to a pH of 10 with a concentrated sodium hydroxide solution.
100461 The composition of EXAMPLE 4 is adjusted to a pH of 9 with a 40%
solution of arginine hydroxide.
100471 The composition of EXAMPLE 4 is adjusted to a pH of 8 with a 60%
solution of arginine bicarbonate.
100481 1 gram of triclosan is added to 99g of the composition of EXAMPLE 4 or 7.
100491 The composition of EXAMPLE 4, 5, 6, 7 and 8 is added to a dental tray in a sufficient amount to cover teeth. The tray is affixed to the upper teeth of a patient for 3 hours and then removed. Teeth treated with the composition are judged to be whiter following treatment when comparing to a shade guide.
[00501 A liquid whitening gel composition is prepared by combining the following ingredients:
Liquid Whitening Gel Base Forint'la Ingredient % by weight Water q.s.
Carbopol 1.00 95% Ethyl Alcohol 34.80 Glycerin 5.00 PEG 600 = 10.00 PEG 2M 14.00 [Hydrogen Peroxide 25.00 85% Phosphoric acid 0.05 Mon obasic sodium phosphate 0.05 Arginine phosphate 5 Total 100 [00511 A pressure sensitive whitening adhesive gel composition is prepared by combining the following ingredients:
Composition Ingredients A . B
BM Pressure Sensitive Silicone Adhesive Anediumihkgh tack)* 30.0 30.0 .=
Plastigel 34 34 Sodium percarbonate 25 1: 'VPH202 cx** -0 ' - =
Saccharin 0.8 . 0.50 Flavor 14.00 PI .0 400 _ .
12kt:zit:hie bicarbonate 0.011. 10.0 . *Dissolved M 60% by weight dimethicone . **ex = crossed-linked
EXAMPI.F. 3 100431 25 grams of L-arginine bicarbonate is added to 50 grams of water to form a solution.
II
gams of a 10% carbamide peroxide solution is added to the solution, and a stained extracted tooth from a smoker (approximately 25 cigarettes per day, without visiting a dental hygienist for 5 months) is immersed therein in vitro. The composition is rinsed away following 2 hours of treatment, and the tooth appears to be whiter in color when compared to a shade guide.
100441 A dental bleaching composition is prepared by combining the following ingredients Carbamide peroxide 10%
Water 21%
Glycerine 57%
CARBOPOL 934P 7%
L-arginine 5%
100451 The composition of EXAMPLE 4 is adjusted to a pH of 10 with a concentrated sodium hydroxide solution.
100461 The composition of EXAMPLE 4 is adjusted to a pH of 9 with a 40%
solution of arginine hydroxide.
100471 The composition of EXAMPLE 4 is adjusted to a pH of 8 with a 60%
solution of arginine bicarbonate.
100481 1 gram of triclosan is added to 99g of the composition of EXAMPLE 4 or 7.
100491 The composition of EXAMPLE 4, 5, 6, 7 and 8 is added to a dental tray in a sufficient amount to cover teeth. The tray is affixed to the upper teeth of a patient for 3 hours and then removed. Teeth treated with the composition are judged to be whiter following treatment when comparing to a shade guide.
[00501 A liquid whitening gel composition is prepared by combining the following ingredients:
Liquid Whitening Gel Base Forint'la Ingredient % by weight Water q.s.
Carbopol 1.00 95% Ethyl Alcohol 34.80 Glycerin 5.00 PEG 600 = 10.00 PEG 2M 14.00 [Hydrogen Peroxide 25.00 85% Phosphoric acid 0.05 Mon obasic sodium phosphate 0.05 Arginine phosphate 5 Total 100 [00511 A pressure sensitive whitening adhesive gel composition is prepared by combining the following ingredients:
Composition Ingredients A . B
BM Pressure Sensitive Silicone Adhesive Anediumihkgh tack)* 30.0 30.0 .=
Plastigel 34 34 Sodium percarbonate 25 1: 'VPH202 cx** -0 ' - =
Saccharin 0.8 . 0.50 Flavor 14.00 PI .0 400 _ .
12kt:zit:hie bicarbonate 0.011. 10.0 . *Dissolved M 60% by weight dimethicone . **ex = crossed-linked
Claims (39)
1. A composition comprising a dental whitening agent and arginine in salt form, wherein the dental whitening agent and the arginine in salt form are dispersed within a matrix material.
2. The composition of claim 1, wherein arginine has the L-configuration.
3. The composition of claim 1 or 2, wherein the arginine in salt form is arginine phosphate.
4. The composition of claim 1 or 2, wherein the arginine in salt form is arginine hydrochloride.
5. The composition of claim 1 or 2, wherein the arginine in salt form is arginine percarbonate.
6. The composition of claim 1 or 2, wherein the arginine in salt form is arginine bicarbonate.
7. The composition of any one of claims 1 to 6, wherein the composition comprises from about 0.1% to about 50% by weight of the arginine in salt form.
8. The composition of any one of claims 1 to 7, wherein the matrix material comprises carboxypolymethylene.
9. The composition of claim 8, wherein the matrix material comprises reaction products of carboxypolymethylene.
10. The composition of any one of claims 1 to 7, wherein the matrix material comprises polyvinylpyrrolidone.
11. The composition of any one of claims 1 to 10, wherein the matrix material has a stickiness or resistance to dilution by saliva such that when the composition is placed within a dental tray and the dental tray is positioned over teeth the composition will retain the dental tray in position over the teeth without significant pressure exerted by the dental tray.
12. The composition of any one of claims 1 to 11, further comprising water.
13. The composition of any one of claims 1 to 12, further comprising glycerine.
14. The composition of any one of claims 1 to 13, further comprising polyethylene glycol.
15. The composition of any one of claims 1 to 14, having a pH of about 5 to about 12.
16. The composition of any one of claims 1 to 15, having a pH of about 6.1.
17. The composition of any one of claims 1 to 14, further comprising triethanolamine, sodium hydroxide, or a basic amino acid.
18. The composition of claim 17, having a pH of about 7 to about 9.
19. The composition of claim 17 or 18, wherein the basic amino acid is lysine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, a salt thereof or a combination thereof.
20. The composition of any one of claims 17 to 19, wherein the basic amino acid is in salt form selected from the group consisting of a hydroxide, a hydrochloride, a bicarbonate, and a combination thereof.
21. The composition of any one of claims 1 to 20, wherein the dental whitening agent is selected from the group consisting of a peroxide, a metal chlorite, a perborate, a percarbonate, a peroxyacid, and a combination thereof.
22. The composition of any one of claims 1 to 21, further comprising a carbamide peroxide, sodium perborate, sodium percarbonate, hydrogen peroxide, or a combination thereof.
23. The composition of any one of claims 1 to 22, further comprising a fluoride salt selected from the group consisting of stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium flurosilicate, amine fluoride, ammonium fluoride, and a combination thereof.
24. The composition of any one of claims 1 to 23, further comprising an antibacterial agent selected from the group consisting of a halogenated diphenyl ether, a herbal extract, an essential oil, a bisguanide antiseptic, a quaternary ammonium compound, a benzalkonium chloride, tetradecylpyridinium chloride (TPC), N-tetradecyl-4-ethylpyridinium chloride (TDEPC), a phenolic antiseptic, hexetidine, octenidine, sanguinarine, povidone iodine, delmopinol, salifluor, a metal ion, sanguinarine, propolis, an oxygenating agent, phthalic acid and a salt thereof, monoperthalic acid, a salt and ester thereof, ascorbyl stearate, oleoyl sarcosine, alkyl sulfate, dioctyl sulfosuccinate, salicylanilide, domiphen bromide, delmopinol, octapinol, a piperidino derivative, a nicin preparation, a chlorite salt, and a mixture of any of the foregoing.
25. The composition of claim 24, wherein the halogenated diphenyl ether is triclosan.
26. The composition of claim 24, wherein the herbal extract or essential oil is rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinokitol, catechol, methyl salicylate, epigallocatechin gallate, epigallocatechin, gallic acid, miswak extract, or sea-buckthorn extract.
27. The composition of claim 24, wherein the bisguanide antiseptic is chlorhexidine, alexidine or octenidine.
28. The composition of claim 24, wherein the quaternary ammonium compound is cetylpyridinium chloride (CPC).
29. The composition of claim 24, wherein the metal ion is a zinc salt.
30. The composition of claim 24, wherein the metal ion is a stannous salt, a copper salt, or an iron salt.
31. The composition of claim 24, wherein the oxygenating agent is hydrogen peroxide, or a buffered sodium peroxyborate or peroxycarbonate.
32. The composition of any one claims 1 to 31, which is a gel.
33. A device for bleaching a patient's tooth comprising a delivery scaffold which is sized to cover a tooth surface to be bleached, said scaffold coated with the composition of any one of claims 1 to 32.
34. The device of claim 33, wherein the scaffold is a dental tray.
35. The device of claim 33, wherein the scaffold is a strip.
36. Use of the device of any one of claims 33 to 35, for bleaching a tooth.
37. Use of the composition of any one of claims 1 to 32, to whiten teeth and optionally, (i) reduce or inhibit formation of dental caries, (ii) reduce, repair or inhibit pre-carious lesions of the enamel, (iii) reduce or inhibit demineralization and promote remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or inhibit gingivitis, (vi) promote healing of sores or cuts in the mouth, (vii) reduce levels of acid producing bacteria, (viii) increase relative levels of arginolytic bacteria, (ix) inhibit microbial biofilm formation in the oral cavity, (x) raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge, (xi) reduce plaque accumulation, (xii) clean the teeth and oral cavity, (xiii) immunize the teeth against cariogenic bacteria, (xiv) promote systemic health, (xv) reduce erosion, and/or (xvi) treat, relieve or reduce dry mouth.
38. The use of claim 37, wherein (xiv) is the promotion of cardiovascular health.
39. Use of arginine in salt form as an agent for combating cavity formation and tooth sensitivity in a dental whitening composition.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2742908P | 2008-02-08 | 2008-02-08 | |
| US61/027,429 | 2008-02-08 | ||
| PCT/US2009/033306 WO2009100277A2 (en) | 2008-02-08 | 2009-02-06 | Compositions and devices |
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| Publication Number | Publication Date |
|---|---|
| CA2710583A1 CA2710583A1 (en) | 2009-08-13 |
| CA2710583C true CA2710583C (en) | 2015-10-06 |
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| CA2710583A Active CA2710583C (en) | 2008-02-08 | 2009-02-06 | Compositions and devices |
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| EP (1) | EP2249791A4 (en) |
| JP (2) | JP2011510094A (en) |
| CN (2) | CN101938981A (en) |
| AR (1) | AR070592A1 (en) |
| AU (1) | AU2009212333C1 (en) |
| BR (1) | BRPI0907105B1 (en) |
| CA (1) | CA2710583C (en) |
| CO (1) | CO6290631A2 (en) |
| MX (1) | MX2010007739A (en) |
| MY (1) | MY156511A (en) |
| RU (1) | RU2505282C2 (en) |
| TW (1) | TWI399218B (en) |
| WO (1) | WO2009100277A2 (en) |
| ZA (1) | ZA201003696B (en) |
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2009
- 2009-02-06 BR BRPI0907105A patent/BRPI0907105B1/en not_active IP Right Cessation
- 2009-02-06 AU AU2009212333A patent/AU2009212333C1/en active Active
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- 2009-02-06 US US12/866,780 patent/US9918918B2/en active Active
- 2009-02-06 RU RU2010137347/15A patent/RU2505282C2/en active
- 2009-02-06 JP JP2010544487A patent/JP2011510094A/en active Pending
- 2009-02-06 TW TW098103766A patent/TWI399218B/en not_active IP Right Cessation
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| CA2710583A1 (en) | 2009-08-13 |
| AU2009212333B2 (en) | 2011-12-08 |
| CN101938981A (en) | 2011-01-05 |
| AR070592A1 (en) | 2010-04-21 |
| AU2009212333C1 (en) | 2012-07-19 |
| TW200948387A (en) | 2009-12-01 |
| MX2010007739A (en) | 2010-08-10 |
| EP2249791A4 (en) | 2014-01-08 |
| JP2014148536A (en) | 2014-08-21 |
| CN105362087A (en) | 2016-03-02 |
| ZA201003696B (en) | 2015-07-29 |
| WO2009100277A2 (en) | 2009-08-13 |
| BRPI0907105A2 (en) | 2016-05-03 |
| AU2009212333A1 (en) | 2009-08-13 |
| US20100322988A1 (en) | 2010-12-23 |
| TWI399218B (en) | 2013-06-21 |
| BRPI0907105B1 (en) | 2016-11-22 |
| US9918918B2 (en) | 2018-03-20 |
| JP2011510094A (en) | 2011-03-31 |
| MY156511A (en) | 2016-02-26 |
| CO6290631A2 (en) | 2011-06-20 |
| RU2010137347A (en) | 2012-03-20 |
| WO2009100277A3 (en) | 2009-11-12 |
| EP2249791A2 (en) | 2010-11-17 |
| RU2505282C2 (en) | 2014-01-27 |
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