CA2708347A1 - Transdermal patch incorporating active agent migration barrier layer - Google Patents
Transdermal patch incorporating active agent migration barrier layer Download PDFInfo
- Publication number
- CA2708347A1 CA2708347A1 CA2708347A CA2708347A CA2708347A1 CA 2708347 A1 CA2708347 A1 CA 2708347A1 CA 2708347 A CA2708347 A CA 2708347A CA 2708347 A CA2708347 A CA 2708347A CA 2708347 A1 CA2708347 A1 CA 2708347A1
- Authority
- CA
- Canada
- Prior art keywords
- active agent
- outer layer
- layer
- release liner
- host
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
Abstract
Devices (100) for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch (100).
One outer layer (110) functions as the primary adhesive layer for adhering the patch (100) to the host. The other inner layer (122) contains at least one active agent to be administered to the host. The inner layer (122) is bonded to the outer layer (110) through an opening (114) provided in an interposed active agent impermeable release layer (104). The release layer (104) separates a circumferential portion of the active agent containing inner layer (122) from the outer adhesive layer (220) to inhibit migration of the active agent therebetween.
One outer layer (110) functions as the primary adhesive layer for adhering the patch (100) to the host. The other inner layer (122) contains at least one active agent to be administered to the host. The inner layer (122) is bonded to the outer layer (110) through an opening (114) provided in an interposed active agent impermeable release layer (104). The release layer (104) separates a circumferential portion of the active agent containing inner layer (122) from the outer adhesive layer (220) to inhibit migration of the active agent therebetween.
Claims
THE EMBODIMENTS OF THE INVENTION IN WICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
35. A device for the release of an active agent to the skin or mucosa of a host, said device comprising:
an outer layer having adhesive properties;
an inner body containing an active agent and having an active agent impermeable layer, said inner body arranged having said impermeable layer opposing said outer layer, said outer layer having an annular portion unopposed by said impermeable layer and surrounding the perimeter of said inner body;
a release liner covering said annular portion of said outer layer and interposed between a first portion of the outer layer and a first opposing portion of the impermeable layer, said release liner having an opening exposing a second portion of said outer layer to a second opposing portion of said impermeable layer, said second portion of said outer layer adhered to said second opposing portion of said impermeable layer;
whereupon removal of said release liner exposes the annular portion of the outer layer for adhering the device to the skin or mucosa of a host.
36. The device of claim 35, wherein said release liner comprises an active agent impermeable material.
37. The device of claim 36, wherein said release liner is releasably adhered to said outer layer.
38. The device of claim 35, wherein said second opposing portion of said impermeable layer includes a circumferential portion surrounding said opening within said release liner, said circumferential portion separated from said second portion of said outer layer by said release liner interposed therebetween.
39. The device of any one of claims 35-38, wherein said inner body comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
40. The device of any one of claims 35-38, further including a layer of active agent permeable adhesive applied overlying said inner body for adhering said device to the skin or mucosa of a host.
41. The device of any one of claims 35-38, wherein at least one portion of said outer layer includes an active agent to be administered to the skin or mucosa of a host.
42. The device of claim 35, further including a second release liner releasably adhered to said inner body.
43. The device of any one of claims 35-42, wherein said active agent is a psychoactive active agent.
44. The device of any one of claims 35-42, wherein said active agent is a sedative.
45. The device of any one of claims 35-42, wherein said active agent is an antidepressant.
46. The device of any one of claims 35-42, wherein said active agent is an anticonvulsant.
47. The device of any one of claims 35-42, wherein said active agent is a steroid.
48. The device of any one of claims 35-42, wherein said active agent is an analgesic.
49. The device of any one of claims 35-42, wherein said active agent is a narcotic analgesic.
50. The device of any one of claims 35-42, wherein said active agent is an antimicrobial agent.
51. The device of any one of claims 35-42, wherein said active agent is a tranquilizer.
52. The device of any one of claims 35-42, wherein said active agent is an antineoplastic agent.
53. The device of any one of claims 35-42, wherein said active agent is an antibiotic agent.
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
35. A device for the release of an active agent to the skin or mucosa of a host, said device comprising:
an outer layer having adhesive properties;
an inner body containing an active agent and having an active agent impermeable layer, said inner body arranged having said impermeable layer opposing said outer layer, said outer layer having an annular portion unopposed by said impermeable layer and surrounding the perimeter of said inner body;
a release liner covering said annular portion of said outer layer and interposed between a first portion of the outer layer and a first opposing portion of the impermeable layer, said release liner having an opening exposing a second portion of said outer layer to a second opposing portion of said impermeable layer, said second portion of said outer layer adhered to said second opposing portion of said impermeable layer;
whereupon removal of said release liner exposes the annular portion of the outer layer for adhering the device to the skin or mucosa of a host.
36. The device of claim 35, wherein said release liner comprises an active agent impermeable material.
37. The device of claim 36, wherein said release liner is releasably adhered to said outer layer.
38. The device of claim 35, wherein said second opposing portion of said impermeable layer includes a circumferential portion surrounding said opening within said release liner, said circumferential portion separated from said second portion of said outer layer by said release liner interposed therebetween.
39. The device of any one of claims 35-38, wherein said inner body comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
40. The device of any one of claims 35-38, further including a layer of active agent permeable adhesive applied overlying said inner body for adhering said device to the skin or mucosa of a host.
41. The device of any one of claims 35-38, wherein at least one portion of said outer layer includes an active agent to be administered to the skin or mucosa of a host.
42. The device of claim 35, further including a second release liner releasably adhered to said inner body.
43. The device of any one of claims 35-42, wherein said active agent is a psychoactive active agent.
44. The device of any one of claims 35-42, wherein said active agent is a sedative.
45. The device of any one of claims 35-42, wherein said active agent is an antidepressant.
46. The device of any one of claims 35-42, wherein said active agent is an anticonvulsant.
47. The device of any one of claims 35-42, wherein said active agent is a steroid.
48. The device of any one of claims 35-42, wherein said active agent is an analgesic.
49. The device of any one of claims 35-42, wherein said active agent is a narcotic analgesic.
50. The device of any one of claims 35-42, wherein said active agent is an antimicrobial agent.
51. The device of any one of claims 35-42, wherein said active agent is a tranquilizer.
52. The device of any one of claims 35-42, wherein said active agent is an antineoplastic agent.
53. The device of any one of claims 35-42, wherein said active agent is an antibiotic agent.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/641,654 US8524272B2 (en) | 2003-08-15 | 2003-08-15 | Transdermal patch incorporating active agent migration barrier layer |
| US10/641,654 | 2003-08-15 | ||
| CA2531504A CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2531504A Division CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2708347A1 true CA2708347A1 (en) | 2005-03-03 |
| CA2708347C CA2708347C (en) | 2012-12-18 |
Family
ID=34136410
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2637849A Expired - Fee Related CA2637849C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA2531504A Expired - Fee Related CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA2638743A Expired - Fee Related CA2638743C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA002637297A Expired - Fee Related CA2637297C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA2637321A Expired - Fee Related CA2637321C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA2708347A Expired - Fee Related CA2708347C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2637849A Expired - Fee Related CA2637849C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA2531504A Expired - Fee Related CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA2638743A Expired - Fee Related CA2638743C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA002637297A Expired - Fee Related CA2637297C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
| CA2637321A Expired - Fee Related CA2637321C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8524272B2 (en) |
| EP (1) | EP1653897A4 (en) |
| JP (1) | JP4388068B2 (en) |
| AU (1) | AU2004266563B2 (en) |
| CA (6) | CA2637849C (en) |
| MX (1) | MXPA06001783A (en) |
| WO (1) | WO2005018517A1 (en) |
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| US20060257460A1 (en) * | 2005-05-13 | 2006-11-16 | Jansen Rolf R | Multilayer drug delivery system with barrier against antagonist exposure |
| EP1928881A2 (en) | 2005-08-19 | 2008-06-11 | Pharmacofore, Inc. | Prodrugs of active agents |
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| EP2402037B8 (en) | 2006-05-26 | 2019-12-04 | Signature Therapeutics, Inc. | Controlled release of phenolic opioids |
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| DE102006054733A1 (en) | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with high drug utilization rate and dosing accuracy |
| DE102007025973A1 (en) * | 2007-06-04 | 2008-12-11 | Lts Lohmann Therapie-Systeme Ag | Storage stable laminate sections |
| JP5394083B2 (en) * | 2008-02-06 | 2014-01-22 | 日東電工株式会社 | Patch packaging structure |
| DE102011080390B3 (en) * | 2011-08-03 | 2012-07-12 | Acino Ag | application aid |
| MX352051B (en) | 2011-09-30 | 2017-11-06 | Verde Environmental Tech Inc | Transdermal patch disposal system. |
| WO2013049387A1 (en) | 2011-09-30 | 2013-04-04 | Teikoku Pharma Usa, Inc. | General medication disposal system |
| CN105287440A (en) * | 2014-06-18 | 2016-02-03 | 杨宁正 | Permeation type pharmaceutic thin film patch |
| GB2556817B (en) | 2015-10-01 | 2019-11-06 | Elysium Therapeutics Inc | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
| US10076473B2 (en) * | 2016-02-15 | 2018-09-18 | C&Tech Corporation | Apparatus and method for manufacturing dried gel sheet and gel sheet or beauty pack manufactured by the same |
| EP3595663A4 (en) | 2017-03-17 | 2021-01-13 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US20190015352A1 (en) * | 2017-07-14 | 2019-01-17 | Pendleton Brewster Wickersham | Applicators & Patches for Dermal & Transdermal Treatment Material & Drug Delivery, Methods of Making Them, & Methods of Use |
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-
2003
- 2003-08-15 US US10/641,654 patent/US8524272B2/en active Active
-
2004
- 2004-01-26 CA CA2637849A patent/CA2637849C/en not_active Expired - Fee Related
- 2004-01-26 CA CA2531504A patent/CA2531504C/en not_active Expired - Fee Related
- 2004-01-26 CA CA2638743A patent/CA2638743C/en not_active Expired - Fee Related
- 2004-01-26 AU AU2004266563A patent/AU2004266563B2/en not_active Ceased
- 2004-01-26 WO PCT/US2004/002105 patent/WO2005018517A1/en active Application Filing
- 2004-01-26 CA CA002637297A patent/CA2637297C/en not_active Expired - Fee Related
- 2004-01-26 MX MXPA06001783A patent/MXPA06001783A/en active IP Right Grant
- 2004-01-26 JP JP2006523817A patent/JP4388068B2/en not_active Expired - Fee Related
- 2004-01-26 EP EP04705280A patent/EP1653897A4/en not_active Withdrawn
- 2004-01-26 CA CA2637321A patent/CA2637321C/en not_active Expired - Fee Related
- 2004-01-26 CA CA2708347A patent/CA2708347C/en not_active Expired - Fee Related
-
2013
- 2013-06-13 US US13/916,712 patent/US8802136B2/en not_active Expired - Lifetime
-
2014
- 2014-05-15 US US14/278,486 patent/US9358373B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06001783A (en) | 2006-05-04 |
| CA2638743A1 (en) | 2005-03-03 |
| EP1653897A1 (en) | 2006-05-10 |
| JP2007502649A (en) | 2007-02-15 |
| US8524272B2 (en) | 2013-09-03 |
| US20050037059A1 (en) | 2005-02-17 |
| CA2638743C (en) | 2012-05-22 |
| AU2004266563B2 (en) | 2011-03-10 |
| CA2531504A1 (en) | 2005-03-03 |
| CA2637297A1 (en) | 2005-03-03 |
| CA2708347C (en) | 2012-12-18 |
| CA2637849A1 (en) | 2005-03-03 |
| US20140249492A1 (en) | 2014-09-04 |
| CA2637321C (en) | 2010-04-13 |
| JP4388068B2 (en) | 2009-12-24 |
| AU2004266563A1 (en) | 2005-03-03 |
| US8802136B2 (en) | 2014-08-12 |
| CA2637849C (en) | 2010-04-13 |
| CA2531504C (en) | 2011-04-12 |
| US20130274694A1 (en) | 2013-10-17 |
| WO2005018517A1 (en) | 2005-03-03 |
| US9358373B2 (en) | 2016-06-07 |
| EP1653897A4 (en) | 2012-03-21 |
| CA2637297C (en) | 2009-07-21 |
| CA2637321A1 (en) | 2005-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20220126 |