CA2675170A1 - Two piece cancellous construct for cartilage repair - Google Patents
Two piece cancellous construct for cartilage repair Download PDFInfo
- Publication number
- CA2675170A1 CA2675170A1 CA002675170A CA2675170A CA2675170A1 CA 2675170 A1 CA2675170 A1 CA 2675170A1 CA 002675170 A CA002675170 A CA 002675170A CA 2675170 A CA2675170 A CA 2675170A CA 2675170 A1 CA2675170 A1 CA 2675170A1
- Authority
- CA
- Canada
- Prior art keywords
- bore
- base member
- cartilage
- repair assembly
- cartilage repair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct (20) with a demineralized cancellous cap (30) and a mineralized cylindrical base member (22) defining a blind bore (23) wrth a through going transverse bore (28) intersecting the blind bore (23). The demineralized cancellous cap (30) has a cylindrical top portion (32) and a smaller diameter cylindrical stem (36) extending away from the top portion (32) which fits into the blind bore (23) of the mineralized base member (22). The cap stem (36) defines a transverse through going bore (37) which is aligned with the through going bore (28) of the base member (22) to receive a cylindrical cortical pin (40) holding the cap (30) within the base member (22). The shaped structure (20) is dimensioned to fit in a drilled bore in a cartilage delect area so that the assembly engages the side wall of the drilled bore in an interference fit.
Description
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Claims (24)
1. A cartilage repair assembly for repair of a defect in articular cartilage comprising an allograft bone base member and a cancellous allograft bone cap member mounted to said base member, said cap member possessing at least one substantially demineralized region.
2. A cartilage repair assembly for repair of a defect in articular cartilage comprising a sterile mineralized allograft bone base member defining an axial bore and a through going bore intersecting said axial bore, a demineralized cancellous allograft bone cap member mounted to said base member in said axial bore, said cap member being treated to be non-osteoinductive, said cap member defining a through going bore which is adapted to be aligned with said base member through going bore, said allograft bone base member being sized to have an interference fit in a cut away opening in a cartilage defect area and fastening means inserted through said base member and cap member hold the same in a fixed relationship.
3. A cartilage repair assembly as claimed in claim 2 wherein said mineralized allograft bone base member is cylindrically shaped.
4. A cartilage repair assembly as claimed in claim 2 wherein said allograft bone base member axial bore is a blind bore with at least one through going bore running from the base of said blind bore to the distal end of the base member.
5. A cartilage repair assembly as claimed in claim 2 wherein said allograft bone base member has a plurality of through going bores running the length of the base member.
6. A cartilage repair assembly as claimed in claim 2 wherein said cap member comprises a top disc shaped section and a stem extending from said top disc shaped section.
7. A cartilage repair assembly as claimed in claim 6 wherein said stem defines a through going bore running transverse the axis of the stem.
8. A cartilage repair assembly as claimed in claim 6 wherein said cap member top section is cylindrical and is about 3mm in thickness.
9. A cartilage repair assembly as claimed in claim 5 wherein said plurality of through going bores run parallel to the center axis of the base member.
10. A cartilage repair assembly as claimed in claim 2 wherein said cap member is demineralized to a calcium content of less than 0.2 percent and treated to remove osteoinductivity.
11. A cartilage repair assembly as claimed in claim 9 wherein said bores have a diameter ranging from about 0.5mm to about 2.0mm.
12. A cartilage repair assembly as claimed in claim 2 wherein said fastening means is a cylindrical pin member mounted in said base member bore and said cap member through going bore.
13. A cartilage repair assembly as claimed in claim 2 wherein said fastening means is constructed of allograft cortical bone.
14. A cartilage repair assembly as claimed in claim 6 wherein said cap member top section has a top surface is milled to a degree of curvature that matches the physiological curvature of the cartilage area being repaired.
15. A cartilage repair assembly as claimed in claim 2 wherein said cap member contains milled cartilage pieces and a carrier.
16. A cartilage repair assembly as claimed in claim 2 wherein said cap member contains one or more additives taken from a group consisting of growth factors(FGF-2, FGF-5, FGF-7, IGF-1, TGF-.beta., BMP-2, BMP-4, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide or bioactive glue.
17. A cartilage repair assembly as claimed in claim 2 wherein on the top section of said cap member is demineralized to a residual calcium content less than 0.2%.
18. A cartilage repair assembly as claimed in claim 2 wherein said cap member is constructed with a disc shaped section having at least a top portion non-osteoinductive and a cylindrical shaped stem section extending from said disc shaped section.
19. A cartilage repair assembly for repair of a defect in articular cartilage comprising a cylindrical sterile mineralized allograft bone base member defining a blind bore and a through going bore communicating with said blind bore and positioned transverse to a central axis of said cylindrical base member, an allograft cancellous bone cap member demineralized to have a calcium content of less than 0.2 percent and treated to remove osteoinductivity mounted in said base member blind bore, said cap member including an extended stem which defines a through going bore which can be aligned with said base member through going bore, said allograft bone base member being sized to have an interference fit in a drilled bore in a cartilage defect area and cylindrical pin member mounted in said base member through going bore and said cap member stem through going bore.
20. A cartilage repair assembly for repair of a defect in articular cartilage comprising a sterile mineralized allograft bone base member defining a blind bore, a transverse through going bore intersecting said blind bore, a plurality of through going bores running through said base member parallel to a central axis of the base member and a demineralized cancellous allograft bone cap member mounted to said base member, said cap member being treated to remove osteoinductivity, said cap member defining a through going bore which can be aligned with said bore member bone cartilage cap, said allograft bone base member being sized to have an interference fit in a drilled bore in a cartilage defect area.
21. A cartilage repair assembly as claimed in claim 20 wherein said cap member is demineralized so that it has a calcium content less than 0.2 percent.
22. A cartilage repair assembly as claimed in claim 20 wherein said cartilage repair assembly is cylindrically shaped.
23. A cartilage repair assembly as claimed in claim 20 wherein said cap member contains one or more additives taken from a group consisting of growth factors(FGF-2, FGF-5, FGF-7, IGF-1, TGF-.beta., BMP-2, BMP-4, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide or bioactive glue.
24. A cartilage repair assembly as claimed in claim 20 wherein said cap member has a top surface that is curved to match the physiological curvature of the cartilage area being replaced.
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PCT/US2008/051796 WO2008106254A2 (en) | 2007-01-24 | 2008-01-23 | Two piece cancellous construct for cartilage repair |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112704588A (en) * | 2020-12-21 | 2021-04-27 | 济宁医学院附属医院 | Personalized customized articular cartilage injury repair device based on 3D printing |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8563232B2 (en) | 2000-09-12 | 2013-10-22 | Lifenet Health | Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
ES2403357T3 (en) | 2003-12-11 | 2013-05-17 | Isto Technologies Inc. | Particle Cartilage System |
US7837740B2 (en) * | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
EP1916964A4 (en) | 2005-08-26 | 2015-11-04 | Zimmer Inc | Implants and methods for repair, replacement and treatment of joint disease |
AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US20090012629A1 (en) | 2007-04-12 | 2009-01-08 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
US9744043B2 (en) * | 2007-07-16 | 2017-08-29 | Lifenet Health | Crafting of cartilage |
WO2009036279A1 (en) | 2007-09-14 | 2009-03-19 | Purdue Research Foundation | Demineralized cancellous bone scaffolds |
CA2717725A1 (en) * | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US8685432B2 (en) * | 2008-03-25 | 2014-04-01 | University Of Utah Research Foundation | Controlled release tissue graft combination biomaterials |
JP2011525229A (en) * | 2008-06-19 | 2011-09-15 | ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Bone Screw Footrest Implants, Systems, and Technologies |
US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
US10610364B2 (en) * | 2008-12-04 | 2020-04-07 | Subchondral Solutions, Inc. | Method for ameliorating joint conditions and diseases and preventing bone hypertrophy |
WO2010083051A2 (en) | 2009-01-15 | 2010-07-22 | ProChon Biotech, Ltd. | Cartilage particle tissue mixtures optionally combined with a cancellous construct |
NL2002742C2 (en) * | 2009-04-09 | 2010-10-12 | Univ Delft Tech | Mechanical device for tissue regeneration. |
WO2011031642A2 (en) * | 2009-09-08 | 2011-03-17 | Musculoskeletal Transplant Foundation Inc. | Tissue engineered meniscus repair composition |
WO2011031637A2 (en) * | 2009-09-08 | 2011-03-17 | Musculoskeletal Transplant Foundation Inc. | Tissue engineered meniscus repair composition |
WO2011063279A1 (en) | 2009-11-19 | 2011-05-26 | Knee Creations, Llc | Coordinate mapping system for joint treatment |
EP2501314B1 (en) | 2009-11-20 | 2019-04-10 | Zimmer Knee Creations, Inc. | Instruments for targeting a joint defect |
AU2010321822A1 (en) | 2009-11-20 | 2012-07-12 | Knee Creations, Llc | Instruments for a variable angle approach to a joint |
US8821504B2 (en) | 2009-11-20 | 2014-09-02 | Zimmer Knee Creations, Inc. | Method for treating joint pain and associated instruments |
US8617166B2 (en) | 2009-11-20 | 2013-12-31 | Zimmer Knee Creations, Inc. | Navigation and positioning instruments for joint repair and methods of use |
US8951261B2 (en) | 2009-11-20 | 2015-02-10 | Zimmer Knee Creations, Inc. | Subchondral treatment of joint pain |
US8608802B2 (en) | 2009-11-20 | 2013-12-17 | Zimmer Knee Creations, Inc. | Implantable devices for subchondral treatment of joint pain |
WO2011063260A1 (en) | 2009-11-20 | 2011-05-26 | Knee Creations, Llc | Bone-derived implantable devices for subchondral treatment of joint pain |
US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
WO2012097506A1 (en) * | 2011-01-19 | 2012-07-26 | 北京大学第三医院 | Matrix for repairing and regenerating articular cartilage and method for preparing the matrix |
US20140236312A1 (en) * | 2011-05-10 | 2014-08-21 | Mark R. Appleford | Cortical bone scaffold for guided osteon regeneration in load-bearing orthopaedic applications |
US8920511B2 (en) | 2011-11-17 | 2014-12-30 | Allosource | Multi-piece machine graft systems and methods |
US10172651B2 (en) | 2012-10-25 | 2019-01-08 | Warsaw Orthopedic, Inc. | Cortical bone implant |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US9265609B2 (en) | 2013-01-08 | 2016-02-23 | Warsaw Orthopedic, Inc. | Osteograft implant |
WO2014123978A2 (en) | 2013-02-05 | 2014-08-14 | University Of Utah Research Foundation | Implantable devices for bone or joint defects |
WO2014130883A2 (en) | 2013-02-22 | 2014-08-28 | Allosource | Cartilage mosaic compositions and methods |
US9289452B2 (en) | 2013-03-07 | 2016-03-22 | Allosource | Consistent calcium content bone allograft systems and methods |
KR102138399B1 (en) | 2013-03-15 | 2020-07-27 | 알로소스 | Perforated osteochondral allograft compositions |
WO2014150784A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
US9730796B2 (en) | 2014-05-16 | 2017-08-15 | Allosource | Composite bone constructs and methods |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US11666447B1 (en) * | 2015-03-05 | 2023-06-06 | Taq Ortho, LLC | Bone implant augment and offset device |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
US20170056190A1 (en) * | 2015-08-27 | 2017-03-02 | Wright Medical Technology, Inc. | Subtalar biofoam wedge |
CN108289733A (en) * | 2015-10-05 | 2018-07-17 | 孚美公司 | Medical implant and fixed system for medical implant |
EP3838195A1 (en) | 2015-11-25 | 2021-06-23 | Subchondral Solutions, Inc. | Methods, systems and devices for repairing anatomical joint conditions |
US11452796B2 (en) | 2017-06-30 | 2022-09-27 | Allosource | Cellular bone grafts, and methods of manufacture and use |
US10786370B2 (en) | 2017-12-28 | 2020-09-29 | Industrial Technology Research Institute | Cartilage repair implant, auxiliary surgical tool kit and cartilage repair system |
US11883302B2 (en) | 2021-11-22 | 2024-01-30 | Warsaw Orthopedic, Inc. | Spinal implant having a compressible insert |
CN117398220B (en) * | 2023-12-13 | 2024-04-02 | 北京爱康宜诚医疗器材有限公司 | Cartilage repair prosthesis |
Family Cites Families (539)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3400199A (en) | 1965-02-26 | 1968-09-03 | Leslie L. Balassa | Wound-healing cartilage powder |
US3478145A (en) | 1964-09-15 | 1969-11-11 | American Home Prod | Chromatographic purification of virus with brushite modified by autoclaving |
US3476855A (en) | 1965-02-26 | 1969-11-04 | Leslie L Balassa | Sterilizing and enhancing activity of a finely divided cartilage powder |
US3551560A (en) | 1967-10-02 | 1970-12-29 | Heinrich F Thiele | Process of reconstructing tendons,cartilage,nerve sheaths,and products |
US3772432A (en) | 1971-01-11 | 1973-11-13 | Lescarden Ltd | Cartilage compositions for dental use |
CA992255A (en) | 1971-01-25 | 1976-07-06 | Cutter Laboratories | Prosthesis for spinal repair |
US3966908A (en) | 1973-11-29 | 1976-06-29 | Lescarden Ltd. | Method of treating degenerative joint afflictions |
US4172128A (en) | 1975-03-26 | 1979-10-23 | Erhard Thiele | Process of degrading and regenerating bone and tooth material and products |
US4060081A (en) | 1975-07-15 | 1977-11-29 | Massachusetts Institute Of Technology | Multilayer membrane useful as synthetic skin |
US4201845A (en) | 1976-04-12 | 1980-05-06 | Monsanto Company | Cell culture reactor |
US4378347A (en) | 1980-06-30 | 1983-03-29 | Franco Wayne P | Composition for treating the heart for myocardial infarction |
US4296100A (en) | 1980-06-30 | 1981-10-20 | Franco Wayne P | Method of treating the heart for myocardial infarction |
US4400833A (en) | 1981-06-10 | 1983-08-30 | Kurland Kenneth Z | Means and method of implanting bioprosthetics |
US4442655A (en) | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
AT369990B (en) | 1981-07-28 | 1983-02-25 | Immuno Ag | METHOD FOR PRODUCING A TISSUE ADHESIVE |
US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
US4505266A (en) | 1981-10-26 | 1985-03-19 | Massachusetts Institute Of Technology | Method of using a fibrous lattice |
US4479271A (en) | 1981-10-26 | 1984-10-30 | Zimmer, Inc. | Prosthetic device adapted to promote bone/tissue ingrowth |
US4458678A (en) | 1981-10-26 | 1984-07-10 | Massachusetts Institute Of Technology | Cell-seeding procedures involving fibrous lattices |
JPS5891755A (en) * | 1981-11-26 | 1983-05-31 | Sunstar Giken Kk | Epoxy resin composition and its preparation |
US4501269A (en) | 1981-12-11 | 1985-02-26 | Washington State University Research Foundation, Inc. | Process for fusing bone joints |
IL68218A (en) | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4801299A (en) | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
US4932973A (en) | 1983-09-30 | 1990-06-12 | El Gendler | Cartilage and bone induction by artificially perforated organic bone matrix |
US5155214A (en) | 1984-03-05 | 1992-10-13 | The Salk Institute For Biological Studies | Basic fibroblast growth factor |
US4609551A (en) | 1984-03-20 | 1986-09-02 | Arnold Caplan | Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites |
US4600574A (en) | 1984-03-21 | 1986-07-15 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of producing a tissue adhesive |
US4757017A (en) | 1984-09-14 | 1988-07-12 | Mcw Research Foundation, Inc. | In vitro cell culture system |
CH665348A5 (en) | 1985-01-09 | 1988-05-13 | Sulzer Ag | IMPLANTS. |
CH665770A5 (en) | 1985-01-25 | 1988-06-15 | Sulzer Ag | PLASTIC BONE IMPLANT. |
CA1260391A (en) | 1985-03-28 | 1989-09-26 | Karl A. Piez | Xenogeneic collagen/mineral preparations in bone repair |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4627853A (en) * | 1985-05-29 | 1986-12-09 | American Hospital Supply Corporation | Method of producing prostheses for replacement of articular cartilage and prostheses so produced |
US5053049A (en) | 1985-05-29 | 1991-10-01 | Baxter International | Flexible prostheses of predetermined shapes and process for making same |
US4681763A (en) | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
US5266476A (en) | 1985-06-18 | 1993-11-30 | Yeda Research & Development Co., Ltd. | Fibrous matrix for in vitro cell cultivation |
IL76079A (en) | 1985-08-13 | 1991-03-10 | Univ Ramot | Collagen implants |
US5604293A (en) | 1985-09-12 | 1997-02-18 | Scios Inc. | Recombinant human basic fibroblast growth factor |
US5439818A (en) | 1985-09-12 | 1995-08-08 | Scios Nova Inc. | DNA encoding human recombinant basic fibroblast growth factor |
US4656137A (en) | 1985-09-12 | 1987-04-07 | Lescarden Inc | Method of processing animal cartilage |
US5859208A (en) | 1988-07-06 | 1999-01-12 | Fiddes; John C. | Human basic fibroblast growth factor analog |
US4994559A (en) | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
US4776173A (en) | 1985-12-20 | 1988-10-11 | Angio-Medical Corporation | Method for extracting a substance from animal derived material |
US6005161A (en) | 1986-01-28 | 1999-12-21 | Thm Biomedical, Inc. | Method and device for reconstruction of articular cartilage |
US5032508A (en) | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
SU1454423A1 (en) | 1986-06-27 | 1989-01-30 | Киевский Медицинский Институт Им.Акад.А.А.Богомольца | Method of recovery of articular surface of cystic condyles of the femur in case of rheumatoid arthritis |
GB8618374D0 (en) | 1986-07-28 | 1986-09-03 | Hsc Res Dev Corp | Biological vascular prostheses |
FI80605C (en) | 1986-11-03 | 1990-07-10 | Biocon Oy | Bone surgical biocomposite material |
CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
US5041138A (en) | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
US5736372A (en) | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
GB8708009D0 (en) | 1987-04-03 | 1987-05-07 | Clayton Found Res | Injectable soft tissue augmentation materials |
US4846835A (en) | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
US4880429A (en) | 1987-07-20 | 1989-11-14 | Stone Kevin R | Prosthetic meniscus |
US5007934A (en) | 1987-07-20 | 1991-04-16 | Regen Corporation | Prosthetic meniscus |
US5681353A (en) | 1987-07-20 | 1997-10-28 | Regen Biologics, Inc. | Meniscal augmentation device |
US5306311A (en) | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
US5260420A (en) | 1987-07-30 | 1993-11-09 | Centre Regional De Transfusion Sanguine De Lille | Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof |
US4950296A (en) | 1988-04-07 | 1990-08-21 | Mcintyre Jonathan L | Bone grafting units |
US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
CH674139A5 (en) | 1988-04-21 | 1990-05-15 | Sulzer Ag | |
US4904259A (en) | 1988-04-29 | 1990-02-27 | Samuel Itay | Compositions and methods for repair of cartilage and bone |
US5053050A (en) | 1988-04-29 | 1991-10-01 | Samuel Itay | Compositions for repair of cartilage and bone |
US4837379A (en) | 1988-06-02 | 1989-06-06 | Organogenesis Inc. | Fibrin-collagen tissue equivalents and methods for preparation thereof |
US4950483A (en) | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5496722A (en) | 1988-06-30 | 1996-03-05 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom |
US4902508A (en) | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
DE3826915A1 (en) | 1988-08-09 | 1990-02-15 | Henkel Kgaa | NEW MATERIALS FOR BONE REPLACEMENT AND BONE OR PROSTHESIS COMPOSITION |
US5649904A (en) * | 1988-10-07 | 1997-07-22 | Sandoz Ltd. | Method of treating cancer with a fully myeloablative regimen of chemotherapy, radiation or both |
US4971954A (en) | 1988-11-23 | 1990-11-20 | University Of Medicine And Dentistry Of New Jersey | Collagen-based matrices ribose cross-linked |
US4963146A (en) | 1989-04-20 | 1990-10-16 | Colla-Tec Incorporated | Multi-layered, semi-permeable conduit for nerve regeneration |
US5576288A (en) | 1989-04-27 | 1996-11-19 | The Salk Institute For Biological Studies | Fibroblast growth factor conjugates |
US5191067A (en) | 1989-04-27 | 1993-03-02 | The Salk Institute For Biological Studies | Fibroblast growth factor conjugates |
US4994084A (en) | 1989-06-23 | 1991-02-19 | Brennan H George | Reconstructive surgery method and implant |
US5290558A (en) | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
US5073373A (en) | 1989-09-21 | 1991-12-17 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
US5236456A (en) | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
US5152791A (en) | 1989-12-07 | 1992-10-06 | Olympus Optical Co., Ltd. | Prosthetic artificial bone having ceramic layers of different porosity |
US5067964A (en) | 1989-12-13 | 1991-11-26 | Stryker Corporation | Articular surface repair |
US5118512A (en) | 1990-01-23 | 1992-06-02 | Osteotech, Inc. (A Delaware Corp.) | Process for cryopreserving biological materials and materials prepared thereby |
US5425769A (en) | 1990-04-23 | 1995-06-20 | Snyders, Jr.; Robert V. | Composition of material for osseous repair |
FR2664808A1 (en) | 1990-07-23 | 1992-01-24 | Gersberg Eduardo | System of dental implants |
US5067963A (en) | 1990-08-21 | 1991-11-26 | Washington University | Method of making live autogenous skeletal replacement parts |
US5336616A (en) | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
DE69111021T2 (en) | 1990-10-31 | 1996-01-04 | Gendler El | Flexible membrane made from organic bone matrix for repairing and restoring bones. |
US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
DE69119869T2 (en) | 1990-11-23 | 1996-12-12 | American Cyanamid Co | Chimeric fibroblast growth factor |
US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US5312456A (en) | 1991-01-31 | 1994-05-17 | Carnegie Mellon University | Micromechanical barb and method for making the same |
US5206023A (en) | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US5853746A (en) | 1991-01-31 | 1998-12-29 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier |
JP3385040B2 (en) | 1991-02-14 | 2003-03-10 | 武田薬品工業株式会社 | Glial activator and method for producing the same |
US5192312A (en) | 1991-03-05 | 1993-03-09 | Colorado State University Research Foundation | Treated tissue for implantation and methods of treatment and use |
DE4215137A1 (en) | 1991-06-04 | 1992-12-10 | Man Ceramics Gmbh | IMPLANT FOR SPINE PILLARS |
US6440427B1 (en) | 1991-06-17 | 2002-08-27 | Biovitrum Ab | Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer |
SE9101853D0 (en) | 1991-06-17 | 1991-06-17 | Jonas Wadstroem | IMPROVED TISSUE ASHESIVE |
DE4120325A1 (en) | 1991-06-20 | 1992-12-24 | Merck Patent Gmbh | IMPLANT MATERIAL |
US5356629A (en) | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
US5329846A (en) | 1991-08-12 | 1994-07-19 | Bonutti Peter M | Tissue press and system |
US6503277B2 (en) | 1991-08-12 | 2003-01-07 | Peter M. Bonutti | Method of transplanting human body tissue |
US5092887A (en) | 1991-08-12 | 1992-03-03 | El Gendler | Artificial ligament produced from demineralized bone for the replacement and augmentation of ligaments, tendons and other fibrous connective tissue |
US5270300A (en) | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
US5281422A (en) | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
US5261422A (en) * | 1991-10-29 | 1993-11-16 | Kelly Michael P | Acoustic administration of remedies process and device |
US5284155A (en) | 1991-12-06 | 1994-02-08 | The General Hospital Corporation | Cartilage degradation assay system |
US5513662A (en) | 1991-12-31 | 1996-05-07 | Osteotech, Inc. | Preparation of bone for transplantation |
US5314476A (en) * | 1992-02-04 | 1994-05-24 | Osteotech, Inc. | Demineralized bone particles and flowable osteogenic composition containing same |
CA2117379C (en) | 1992-02-14 | 1999-11-16 | Kypriacos A. Athanasiou | Multi-phase bioerodible implant/carrier and method of manufacturing and using same |
US5876452A (en) | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
US6013853A (en) | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
WO1993016739A1 (en) | 1992-02-19 | 1993-09-02 | Eberlin Jean Luc | Collagen- and fibrin adhesive-based graft for osteocartilaginous reconstruction, and preparation method therefor |
US5326357A (en) | 1992-03-18 | 1994-07-05 | Mount Sinai Hospital Corporation | Reconstituted cartridge tissue |
GB9206509D0 (en) | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges containing active agents |
US5256140A (en) | 1992-03-27 | 1993-10-26 | Fallien Cosmeceuticals, Ltd. | Composition for levelling skin |
CA2135180A1 (en) * | 1992-05-08 | 1993-11-25 | Gavin S. P. Miller | Textured sphere and sperical environment map rendering using texture map double indirection |
US5800537A (en) | 1992-08-07 | 1998-09-01 | Tissue Engineering, Inc. | Method and construct for producing graft tissue from an extracellular matrix |
DE69333466T2 (en) | 1992-08-07 | 2004-08-19 | TEI Biosciences, Inc., Boston | PRODUCTION OF TRANSPLANT TISSUE FROM EXTRACELLULAR MATRIX |
US5195791A (en) * | 1992-08-13 | 1993-03-23 | Hu Chiu S | Portable security buckle for doors |
US5275826A (en) | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
US5352463A (en) | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
EP0608546A3 (en) | 1992-12-22 | 1995-09-27 | Takeda Chemical Industries Ltd | Glia activating factor (gaf), antibodies against it and their uses. |
US5549904A (en) | 1993-06-03 | 1996-08-27 | Orthogene, Inc. | Biological adhesive composition and method of promoting adhesion between tissue surfaces |
US5380328A (en) | 1993-08-09 | 1995-01-10 | Timesh, Inc. | Composite perforated implant structures |
US5491220A (en) | 1993-09-24 | 1996-02-13 | Yeda Research And Development Co., Ltd. | Surface loop structural analogues of fibroblast growth factors |
US5507813A (en) | 1993-12-09 | 1996-04-16 | Osteotech, Inc. | Shaped materials derived from elongate bone particles |
US5411885A (en) | 1993-12-17 | 1995-05-02 | New York Blood Center, Inc. | Methods for tissue embedding and tissue culturing |
US5656598A (en) | 1994-03-08 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Use of fibroblast growth factors to stimulate bone growth |
AU685619B2 (en) | 1994-03-08 | 1998-01-22 | Osteosa Inc. | Use of fibroblast growth factors to stimulate bone growth |
ATE265191T1 (en) | 1994-03-14 | 2004-05-15 | Cryolife Inc | PRODUCTION PROCESS OF TISSUE FOR IMPLANTATION |
CA2162997A1 (en) | 1994-03-18 | 1995-09-28 | Daphne C. Tse | Topical fibrinogen complex |
US5916265A (en) | 1994-03-30 | 1999-06-29 | Hu; Jie | Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant |
US5618925A (en) | 1994-04-28 | 1997-04-08 | Les Laboratories Aeterna Inc. | Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof |
US6025334A (en) | 1994-04-28 | 2000-02-15 | Les Laboratoires Aeterna Inc. | Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof |
US5723331A (en) | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
WO1998020939A2 (en) | 1996-11-15 | 1998-05-22 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
US7963997B2 (en) | 2002-07-19 | 2011-06-21 | Kensey Nash Corporation | Device for regeneration of articular cartilage and other tissue |
US5906827A (en) | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
IL110367A (en) | 1994-07-19 | 2007-05-15 | Colbar Lifescience Ltd | Collagen-based matrix |
US5516532A (en) | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
US5632745A (en) | 1995-02-07 | 1997-05-27 | R&D Biologicals, Inc. | Surgical implantation of cartilage repair unit |
US5769899A (en) | 1994-08-12 | 1998-06-23 | Matrix Biotechnologies, Inc. | Cartilage repair unit |
US5707962A (en) | 1994-09-28 | 1998-01-13 | Gensci Regeneration Sciences Inc. | Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof |
TW369414B (en) | 1994-09-30 | 1999-09-11 | Yamanouchi Pharma Co Ltd | Bone formation transplant |
US5919892A (en) * | 1994-10-31 | 1999-07-06 | The Dow Chemical Company | Polyamic acids and methods to convert polyamic acids into polyimidebenzoxazole films |
US20010011131A1 (en) | 1997-07-28 | 2001-08-02 | Luyten Frank P. | DNA molecules encoding cartilage-derived morphogenetic proteins |
US5891558A (en) | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
US5709934A (en) | 1994-11-22 | 1998-01-20 | Tissue Engineering, Inc. | Bipolymer foams having extracellular matrix particulates |
US6599515B1 (en) | 1995-01-16 | 2003-07-29 | Baxter International Inc. | Fibrin porous structure |
WO1996022115A1 (en) | 1995-01-16 | 1996-07-25 | Baxter International Inc. | Self-supporting sheet-like material of cross-linked fibrin for preventing post operative adhesions |
US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
US5749874A (en) | 1995-02-07 | 1998-05-12 | Matrix Biotechnologies, Inc. | Cartilage repair unit and method of assembling same |
US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
US5713374A (en) | 1995-02-10 | 1998-02-03 | The Hospital For Joint Diseases Orthopaedic Institute | Fixation method for the attachment of wound repair materials to cartilage defects |
US6080194A (en) | 1995-02-10 | 2000-06-27 | The Hospital For Joint Disease Orthopaedic Institute | Multi-stage collagen-based template or implant for use in the repair of cartilage lesions |
US7141072B2 (en) | 1998-10-05 | 2006-11-28 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering |
US20030039695A1 (en) | 2001-08-10 | 2003-02-27 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Collagen carrier of therapeutic genetic material, and method |
GB9721585D0 (en) | 1997-10-10 | 1997-12-10 | Geistlich Soehne Ag | Chemical product |
US5782835A (en) | 1995-03-07 | 1998-07-21 | Innovasive Devices, Inc. | Apparatus and methods for articular cartilage defect repair |
US5733337A (en) | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
US5554389A (en) | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
EP0821573A4 (en) | 1995-04-19 | 2000-08-09 | St Jude Medical | Matrix substrate for a viable body tissue-derived prosthesis and method for making the same |
US5904716A (en) | 1995-04-26 | 1999-05-18 | Gendler; El | Method for reconstituting cartilage tissue using demineralized bone and product thereof |
US6060640A (en) | 1995-05-19 | 2000-05-09 | Baxter International Inc. | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue |
US6039762A (en) | 1995-06-07 | 2000-03-21 | Sdgi Holdings, Inc. | Reinforced bone graft substitutes |
US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
US5782915A (en) | 1995-09-15 | 1998-07-21 | Stone; Kevin R. | Articular cartilage heterografts |
CA2234054C (en) | 1995-10-06 | 2010-09-14 | Microcloning Cccd Ab | Compact cell culture disk |
US5716413A (en) | 1995-10-11 | 1998-02-10 | Osteobiologics, Inc. | Moldable, hand-shapable biodegradable implant material |
US5989289A (en) | 1995-10-16 | 1999-11-23 | Sdgi Holdings, Inc. | Bone grafts |
US20020111695A1 (en) | 1995-11-06 | 2002-08-15 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
US5788626A (en) * | 1995-11-21 | 1998-08-04 | Schneider (Usa) Inc | Method of making a stent-graft covered with expanded polytetrafluoroethylene |
IL116477A (en) | 1995-12-21 | 2000-02-29 | Hadasit Med Res Service | Bone graft substitute and process for producing same |
US5814084A (en) | 1996-01-16 | 1998-09-29 | University Of Florida Tissue Bank, Inc. | Diaphysial cortical dowel |
US5964724A (en) | 1996-01-31 | 1999-10-12 | Medtronic Electromedics, Inc. | Apparatus and method for blood separation |
US5842477A (en) | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
US6352558B1 (en) | 1996-02-22 | 2002-03-05 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method for promoting regeneration of surface cartilage in a damage joint |
US6221854B1 (en) | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
US5700774A (en) | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
US5788625A (en) | 1996-04-05 | 1998-08-04 | Depuy Orthopaedics, Inc. | Method of making reconstructive SIS structure for cartilaginous elements in situ |
US5755791A (en) | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
AU731468B2 (en) | 1996-04-19 | 2001-03-29 | Mesoblast International Sarl | Regeneration and augmentation of bone using mesenchymal stem cells |
WO1999023167A1 (en) | 1996-04-26 | 1999-05-14 | Showa Denko K.K. | Composite resin composition |
US6242247B1 (en) | 1996-06-04 | 2001-06-05 | Sulzer Orthopedics Ltd. | Method for making cartilage and implants |
US6280473B1 (en) | 1996-08-19 | 2001-08-28 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
US6666892B2 (en) | 1996-08-23 | 2003-12-23 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
US5759190A (en) | 1996-08-30 | 1998-06-02 | Vts Holdings Limited | Method and kit for autologous transplantation |
US6569172B2 (en) | 1996-08-30 | 2003-05-27 | Verigen Transplantation Service International (Vtsi) | Method, instruments, and kit for autologous transplantation |
US5989269A (en) | 1996-08-30 | 1999-11-23 | Vts Holdings L.L.C. | Method, instruments and kit for autologous transplantation |
US6189537B1 (en) | 1996-09-06 | 2001-02-20 | Lifenet | Process for producing osteoinductive bone, and osteoinductive bone produced thereby |
US5964805A (en) | 1997-02-12 | 1999-10-12 | Stone; Kevin R. | Method and paste for articular cartilage transplantation |
US5881733A (en) | 1996-09-13 | 1999-03-16 | Depuy Orthopaedic Technology, Inc. | Technique for osteocartilaginous transplantation in a mammalian joint |
US6165487A (en) | 1996-09-30 | 2000-12-26 | Children's Medical Center Corporation | Methods and compositions for programming an organic matrix for remodeling into a target tissue |
EP0929322A1 (en) | 1996-09-30 | 1999-07-21 | Children's Medical Center Corporation | Methods and compositions for programming an organic matrix for remodeling into a target tissue |
US6884871B2 (en) | 1996-10-11 | 2005-04-26 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation and use of tissue growth-inducing Frzb protein |
ATE318906T1 (en) | 1996-10-16 | 2006-03-15 | Zymogenetics Inc | FIBROBLAST GROWTH FACTORS HOMOLOGOFIBROBLAST GROWTH FACTORS HOMOLOGOUS |
KR20000052740A (en) | 1996-10-23 | 2000-08-25 | 에스디지아이 홀딩스 인코포레이티드 | Spinal spacer |
US5974663A (en) | 1996-10-25 | 1999-11-02 | Honda Giken Kogya Kabushiki Kaisha | Method of manufacturing connecting rod |
DE69730039T2 (en) | 1996-11-05 | 2005-07-14 | Purdue Research Foundation, West Lafayette | HEART transplants |
DE19647853A1 (en) | 1996-11-19 | 1998-05-20 | Bioph Biotech Entw Pharm Gmbh | Compounds with improved cartilage and / or bone inducing activity |
US5728159A (en) | 1997-01-02 | 1998-03-17 | Musculoskeletal Transplant Foundation | Serrated bone graft |
US7468075B2 (en) | 2001-05-25 | 2008-12-23 | Conformis, Inc. | Methods and compositions for articular repair |
US8545569B2 (en) | 2001-05-25 | 2013-10-01 | Conformis, Inc. | Patient selectable knee arthroplasty devices |
US5866165A (en) | 1997-01-15 | 1999-02-02 | Orquest, Inc. | Collagen-polysaccharide matrix for bone and cartilage repair |
EP2332564A1 (en) | 1997-02-07 | 2011-06-15 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods thereof |
US6146385A (en) | 1997-02-11 | 2000-11-14 | Smith & Nephew, Inc. | Repairing cartilage |
US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
US5866415A (en) | 1997-03-25 | 1999-02-02 | Villeneuve; Peter E. | Materials for healing cartilage and bone defects |
US6001352A (en) | 1997-03-31 | 1999-12-14 | Osteobiologics, Inc. | Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor |
CA2307954C (en) | 1997-04-03 | 2010-07-13 | California Institute Of Technology | Enzyme-medicated modification of fibrin for tissue engineering |
JP4394169B2 (en) | 1997-04-04 | 2010-01-06 | バーンズ − ジューウィッシュ・ホスピタル | New cartilage and methods of use |
AU738334B2 (en) | 1997-05-30 | 2001-09-13 | Osteobiologics, Inc. | Fiber-reinforced, porous, biodegradable implant device |
US7524335B2 (en) | 1997-05-30 | 2009-04-28 | Smith & Nephew, Inc. | Fiber-reinforced, porous, biodegradable implant device |
US5972368A (en) | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
CN1161127C (en) | 1997-07-03 | 2004-08-11 | 奥奎斯特公司 | Cross-linked polysaccharide drug carrier |
US5910315A (en) | 1997-07-18 | 1999-06-08 | Stevenson; Sharon | Allograft tissue material for filling spinal fusion cages or related surgical spaces |
US6471993B1 (en) | 1997-08-01 | 2002-10-29 | Massachusetts Institute Of Technology | Three-dimensional polymer matrices |
US6090996A (en) | 1997-08-04 | 2000-07-18 | Collagen Matrix, Inc. | Implant matrix |
US6110209A (en) | 1997-08-07 | 2000-08-29 | Stone; Kevin R. | Method and paste for articular cartilage transplantation |
EP0896825B1 (en) | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
US6511958B1 (en) | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
US20010031254A1 (en) | 1998-11-13 | 2001-10-18 | Bianchi John R. | Assembled implant |
US20020138143A1 (en) | 1997-08-27 | 2002-09-26 | Grooms Jamie M. | Cortical bone cervical Smith-Robinson fusion implant |
US7048762B1 (en) | 1997-08-27 | 2006-05-23 | Regeneration Technologies, Inc. | Elongated cortical bone implant |
WO1999009914A1 (en) | 1997-08-27 | 1999-03-04 | University Of Florida Tissue Bank, Inc. | Cortical bone cervical smith-robinson fusion implant |
US6309659B1 (en) | 1997-09-02 | 2001-10-30 | Gensci Orthobiologics, Inc. | Reverse phase connective tissue repair composition |
US6077987A (en) | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
AT407117B (en) | 1997-09-19 | 2000-12-27 | Immuno Ag | FIBRINE SPONGE |
US5998170A (en) | 1997-10-03 | 1999-12-07 | Amgen Inc. | Polynucleotides encoding hepatocyte-specific members of the FGF family |
US6090998A (en) | 1997-10-27 | 2000-07-18 | University Of Florida | Segmentally demineralized bone implant |
EP1027001A1 (en) | 1997-10-27 | 2000-08-16 | Sulzer Orthopädie AG | Method and instruments for repairing endochondral and osteochondral defects |
US6652592B1 (en) | 1997-10-27 | 2003-11-25 | Regeneration Technologies, Inc. | Segmentally demineralized bone implant |
US6183737B1 (en) | 1997-10-30 | 2001-02-06 | The General Hospital Corporation | Bonding of cartilage pieces using isolated chondrocytes and a biological gel |
US20030099620A1 (en) | 1997-10-30 | 2003-05-29 | The General Hospital Corporation | Bonding of cartilaginous matrices using isolated chondrocytes |
US6197586B1 (en) | 1997-12-12 | 2001-03-06 | The Regents Of The University Of California | Chondrocyte-like cells useful for tissue engineering and methods |
US6274712B1 (en) | 1997-12-23 | 2001-08-14 | 3-Dimensional Pharmaceuticals, Inc. | Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137 |
US5899939A (en) | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
US6712851B1 (en) | 1998-01-23 | 2004-03-30 | Macropore Biosurgery, Inc. | Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
DE19803673A1 (en) | 1998-01-30 | 1999-08-05 | Norbert M Dr Meenen | Biohybrid joint replacement |
US7087082B2 (en) | 1998-08-03 | 2006-08-08 | Synthes (Usa) | Bone implants with central chambers |
US6123731A (en) | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
US6458375B1 (en) | 1998-02-27 | 2002-10-01 | Musculoskeletal Transplant Foundation | Malleable paste with allograft bone reinforcement for filling bone defects |
US6911212B2 (en) | 1998-02-27 | 2005-06-28 | Musculoskeletal Transplant Foundation | Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects |
US7045141B2 (en) | 1998-02-27 | 2006-05-16 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
USRE38522E1 (en) | 1998-02-27 | 2004-05-25 | Musculoskeletal Transplant Foundation | Malleable paste for filling bone defects |
US6326018B1 (en) | 1998-02-27 | 2001-12-04 | Musculoskeletal Transplant Foundation | Flexible sheet of demineralized bone |
US7019192B2 (en) | 1998-02-27 | 2006-03-28 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
US6437018B1 (en) | 1998-02-27 | 2002-08-20 | Musculoskeletal Transplant Foundation | Malleable paste with high molecular weight buffered carrier for filling bone defects |
US6030635A (en) | 1998-02-27 | 2000-02-29 | Musculoskeletal Transplant Foundation | Malleable paste for filling bone defects |
US6056777A (en) | 1998-02-27 | 2000-05-02 | Mcdowell; Charles L. | Method and device for regenerating cartilage in articulating |
US6143293A (en) | 1998-03-26 | 2000-11-07 | Carnegie Mellon | Assembled scaffolds for three dimensional cell culturing and tissue generation |
US20040044408A1 (en) | 1998-04-08 | 2004-03-04 | Hungerford David S. | Cell-culture and polymer constructs |
CA2330972C (en) | 1998-05-01 | 2008-08-19 | Zymogenetics, Inc. | Fully recombinant tissue sealant compositions |
US6933326B1 (en) | 1998-06-19 | 2005-08-23 | Lifecell Coporation | Particulate acellular tissue matrix |
US6734018B2 (en) | 1999-06-07 | 2004-05-11 | Lifenet | Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced |
US6293970B1 (en) | 1998-06-30 | 2001-09-25 | Lifenet | Plasticized bone and soft tissue grafts and methods of making and using same |
US20080077251A1 (en) | 1999-06-07 | 2008-03-27 | Chen Silvia S | Cleaning and devitalization of cartilage |
ES2207258T3 (en) | 1998-07-13 | 2004-05-16 | University Of Southern California | PROCEDURE TO ACCELERATE THE BEAR AND CARTILAGO GROWTH AND ITS RECOVERY. |
US6274090B1 (en) | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
WO2000007528A1 (en) * | 1998-08-06 | 2000-02-17 | Sdgi Holdings, Inc. | Composited intervertebral bone spacers |
EP1104313A2 (en) | 1998-08-14 | 2001-06-06 | Verigen Transplantation Service International (VTSI) AG | Methods, instruments and materials for chondrocyte cell transplantation |
US6849255B2 (en) | 1998-08-18 | 2005-02-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for enhancing cartilage repair |
US6530956B1 (en) | 1998-09-10 | 2003-03-11 | Kevin A. Mansmann | Resorbable scaffolds to promote cartilage regeneration |
WO2000017321A2 (en) | 1998-09-18 | 2000-03-30 | Massachusetts Institute Of Technology | Use of growth factors and hormones for expansion of mammalian cells and tissue engineering |
US6454811B1 (en) | 1998-10-12 | 2002-09-24 | Massachusetts Institute Of Technology | Composites for tissue regeneration and methods of manufacture thereof |
US6586406B2 (en) | 1998-10-14 | 2003-07-01 | Depuy Acromed, Inc. | Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5 |
US6174311B1 (en) | 1998-10-28 | 2001-01-16 | Sdgi Holdings, Inc. | Interbody fusion grafts and instrumentation |
DE19851334C2 (en) | 1998-11-06 | 2000-09-28 | Aventis Behring Gmbh | Flexible fibrin-based wound dressing and process for its manufacture |
US6497726B1 (en) | 2000-01-11 | 2002-12-24 | Regeneration Technologies, Inc. | Materials and methods for improved bone tendon bone transplantation |
US6761887B1 (en) | 1998-11-16 | 2004-07-13 | Osiris Therapeutics, Inc. | Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells |
US6165486A (en) | 1998-11-19 | 2000-12-26 | Carnegie Mellon University | Biocompatible compositions and methods of using same |
US6025538A (en) | 1998-11-20 | 2000-02-15 | Musculoskeletal Transplant Foundation | Compound bone structure fabricated from allograft tissue |
US6306174B1 (en) | 1998-12-18 | 2001-10-23 | Benoist Girard Sas | Femoral component |
US20020165611A1 (en) | 1998-12-22 | 2002-11-07 | Robert-Jan Enzerink | Graft material convenience package |
US6200347B1 (en) | 1999-01-05 | 2001-03-13 | Lifenet | Composite bone graft, method of making and using same |
US6547823B2 (en) | 1999-01-22 | 2003-04-15 | Osteotech, Inc. | Intervertebral implant |
US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
AU772682B2 (en) | 1999-02-04 | 2004-05-06 | Warsaw Orthopedic, Inc. | Highly-mineralized osteogenic sponge compositions, and uses thereof |
US6267786B1 (en) | 1999-02-11 | 2001-07-31 | Crosscart, Inc. | Proteoglycan-reduced soft tissue xenografts |
WO2000047114A1 (en) | 1999-02-12 | 2000-08-17 | Collagenesis, Inc. | Injectable collagen-based delivery system for bone morphogenic proteins |
US6294187B1 (en) | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
US6696073B2 (en) | 1999-02-23 | 2004-02-24 | Osteotech, Inc. | Shaped load-bearing osteoimplant and methods of making same |
US6197061B1 (en) | 1999-03-01 | 2001-03-06 | Koichi Masuda | In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage |
US6662805B2 (en) | 1999-03-24 | 2003-12-16 | The Johns Hopkins University | Method for composite cell-based implants |
CA2334887C (en) | 1999-04-12 | 2012-01-24 | Harvest Technologies Corporation | Method and apparatus for producing platelet rich plasma and/or platelet concentrate |
US7371400B2 (en) | 2001-01-02 | 2008-05-13 | The General Hospital Corporation | Multilayer device for tissue engineering |
US7297161B2 (en) | 1999-05-10 | 2007-11-20 | Fell Barry M | Surgically implantable knee prosthesis |
US7338524B2 (en) | 1999-05-10 | 2008-03-04 | Fell Barry M | Surgically implantable knee prosthesis |
GB9912240D0 (en) | 1999-05-27 | 1999-07-28 | Smith & Nephew | Implantable medical devices |
US6251143B1 (en) | 1999-06-04 | 2001-06-26 | Depuy Orthopaedics, Inc. | Cartilage repair unit |
US6288043B1 (en) | 1999-06-18 | 2001-09-11 | Orquest, Inc. | Injectable hyaluronate-sulfated polysaccharide conjugates |
US6306424B1 (en) | 1999-06-30 | 2001-10-23 | Ethicon, Inc. | Foam composite for the repair or regeneration of tissue |
US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
US6652872B2 (en) | 1999-07-06 | 2003-11-25 | Ramat At Tel Aviv University Ltd. | Scaffold formed of tissue treated to eliminate cellular and cytosolic elements |
US7056885B1 (en) | 1999-07-27 | 2006-06-06 | Curagen Corporation | Fibroblast growth factor and nucleic acids encoding same |
US7078232B2 (en) | 1999-08-19 | 2006-07-18 | Artecel, Inc. | Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof |
US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
FR2798671A1 (en) | 1999-09-16 | 2001-03-23 | Univ Paris Curie | CHONDROCYTE COMPOSITIONS, PREPARATION AND USES |
US7687462B2 (en) | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
EP1099443A1 (en) | 1999-11-11 | 2001-05-16 | Sulzer Orthopedics Ltd. | Transplant/implant device and method for its production |
AU1628101A (en) | 1999-11-22 | 2001-06-04 | Millennium Pharmaceuticals, Inc. | Jaffa, a novel fibroblast growth factor family member and uses therefor |
DE19957388A1 (en) | 1999-11-24 | 2001-06-13 | Michael Sittinger | Chondroinductive and implantable substrates for cartilage healing and protection |
WO2001039788A2 (en) | 1999-12-02 | 2001-06-07 | Zymogenetics, Inc. | Methods for targeting cells that express fibroblast growth receptor-3 or-2 |
DE19958007A1 (en) * | 1999-12-02 | 2001-06-07 | Roehm Gmbh | Injection molding process for (meth) acrylate copolymers with tertiary ammonium groups |
DE60041670D1 (en) | 1999-12-03 | 2009-04-09 | Univ Leeds | Restoration of damaged tissue |
EP1237511B1 (en) | 1999-12-15 | 2004-09-01 | Sulzer Orthopedics Ltd. | Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints |
US6623963B1 (en) | 1999-12-20 | 2003-09-23 | Verigen Ag | Cellular matrix |
US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
ES2275361T3 (en) | 1999-12-22 | 2007-06-01 | Ortho-Mcneil Pharmaceutical, Inc. | ANALOGS OF THE BASIC HUMAN FIBROBLASTIC GROWTH FACTOR. |
US6376244B1 (en) | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
US6458144B1 (en) | 1999-12-30 | 2002-10-01 | Osteotech, Inc. | Methods for manufacturing skeletal implants |
US6379385B1 (en) | 2000-01-06 | 2002-04-30 | Tutogen Medical Gmbh | Implant of bone matter |
US6893462B2 (en) | 2000-01-11 | 2005-05-17 | Regeneration Technologies, Inc. | Soft and calcified tissue implants |
WO2001078798A1 (en) | 2000-02-10 | 2001-10-25 | Regeneration Technologies, Inc. | Assembled implant |
US6371958B1 (en) | 2000-03-02 | 2002-04-16 | Ethicon, Inc. | Scaffold fixation device for use in articular cartilage repair |
US7182781B1 (en) | 2000-03-02 | 2007-02-27 | Regeneration Technologies, Inc. | Cervical tapered dowel |
US6591581B2 (en) | 2000-03-08 | 2003-07-15 | Arthrex, Inc. | Method for preparing and inserting round, size specific osteochondral cores in the knee |
US6626945B2 (en) | 2000-03-14 | 2003-09-30 | Chondrosite, Llc | Cartilage repair plug |
AR027685A1 (en) | 2000-03-22 | 2003-04-09 | Synthes Ag | METHOD AND METHOD FOR CARRYING OUT |
ATE328605T1 (en) | 2000-03-24 | 2006-06-15 | Genentech Inc | USE OF INSULIN TO TREAT CARTILAGE DISEASES |
EP1142596A1 (en) | 2000-04-03 | 2001-10-10 | Universiteit Gent | Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants |
US6932977B2 (en) | 2000-04-14 | 2005-08-23 | Depuy Spine, Inc. | Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4 |
EP2314257B9 (en) * | 2000-05-01 | 2013-02-27 | ArthroSurface, Inc. | System for joint resurface repair |
US6993328B1 (en) | 2000-05-08 | 2006-01-31 | Nokia Corporation | Method for over the air mobile station management |
US7108721B2 (en) | 2000-05-11 | 2006-09-19 | Massachusetts Institute Of Technology | Tissue regrafting |
EP1280564B1 (en) | 2000-05-12 | 2005-08-31 | Osteotech, Inc. | Surface demineralized osteoimplant and method for making same |
US6488033B1 (en) | 2000-05-15 | 2002-12-03 | Cryolife, Inc. | Osteochondral transplant techniques |
US6686184B1 (en) | 2000-05-25 | 2004-02-03 | President And Fellows Of Harvard College | Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks |
SG149679A1 (en) | 2000-06-29 | 2009-02-27 | Biosyntech Canada Inc | Composition and method for the repair and regeneration of cartilage and other tissues |
KR20030027934A (en) | 2000-07-03 | 2003-04-07 | 오스테오테크 주식회사 | Osteogenic Implants derived from Bone |
US7018416B2 (en) | 2000-07-06 | 2006-03-28 | Zimmer Spine, Inc. | Bone implants and methods |
US9387094B2 (en) | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
DK177997B1 (en) | 2000-07-19 | 2015-02-23 | Ed Geistlich Söhne Ag Für Chemische Ind | Bone material and collagen combination for healing of damaged joints |
US6815416B2 (en) | 2000-07-20 | 2004-11-09 | The Board Of Regents, The University Of Texas System | Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor |
US6440141B1 (en) | 2000-07-24 | 2002-08-27 | Oratec Interventions, Inc. | Method and apparatus for treating osteochondral pathologies |
US9452238B2 (en) | 2000-07-29 | 2016-09-27 | Smith & Nephew LLP | Tissue implant |
US8366787B2 (en) | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
DE10042484A1 (en) | 2000-08-29 | 2002-03-28 | Merck Patent Gmbh | Preparing human cartilage implants, useful for repairing damaged joints, comprises culturing autologous chondrocytes in alginate gel at reduced oxygen partial pressure |
WO2002018546A2 (en) | 2000-09-01 | 2002-03-07 | Virginia Commonwealth University Intellectual Property Foundation | Plasma-derived-fibrin-based matrices and tissue |
IL138529A0 (en) | 2000-09-18 | 2003-09-17 | Yeda Res & Dev | High level expression of heterologous proteins |
US6432436B1 (en) | 2000-10-03 | 2002-08-13 | Musculoskeletal Transplant Foundation | Partially demineralized cortical bone constructs |
US7548865B2 (en) | 2000-10-20 | 2009-06-16 | Arthrex, Inc. | Method of selling procedure specific allografts and associated instrumentation |
IL139380A0 (en) | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
DE60138643D1 (en) | 2000-12-08 | 2009-06-18 | Osteotech Inc | IMPLANT FOR ORTHOPEDIC APPLICATIONS |
CA2365376C (en) | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US6838440B2 (en) | 2001-01-24 | 2005-01-04 | Collagen Nutraceuticals, Inc. | Kolla2-desiccated avian sternal cartilage powder |
JP4246994B2 (en) | 2001-01-30 | 2009-04-02 | オーソジーン, インコーポレイテッド | Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial tissue or cells |
US7931692B2 (en) | 2001-02-14 | 2011-04-26 | Osteotech, Inc. | Implant derived from bone |
AU2002244116A1 (en) | 2001-02-16 | 2002-09-04 | Sulzer Spine-Tech Inc. | Bone implants and methods |
US20030050709A1 (en) | 2001-02-23 | 2003-03-13 | Ulrich Noth | Trabecular bone-derived human mesenchymal stem cells |
US6575986B2 (en) | 2001-02-26 | 2003-06-10 | Ethicon, Inc. | Scaffold fixation device for use in articular cartilage repair |
US6743232B2 (en) | 2001-02-26 | 2004-06-01 | David W. Overaker | Tissue scaffold anchor for cartilage repair |
US6776800B2 (en) | 2001-02-28 | 2004-08-17 | Synthes (U.S.A.) | Implants formed with demineralized bone |
IL141813A (en) | 2001-03-05 | 2010-04-15 | Hadasit Med Res Service | Mixture comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the preparation of compositions for the treatment of hematopoietic dusirders |
US6995013B2 (en) | 2002-07-08 | 2006-02-07 | Biomed Solutions, Llc | Cell-scaffold composition containing five layers |
US7252982B2 (en) | 2001-03-15 | 2007-08-07 | Massachusetts Institute Of Technology | Tissue engineering enhanced by the transfer of a growth factor gene |
JP4500898B2 (en) | 2001-03-23 | 2010-07-14 | 高木産業株式会社 | Compositions and methods for producing biological tissues and tissue constructs |
US20040151705A1 (en) | 2002-03-22 | 2004-08-05 | Shuichi Mizuno | Neo-cartilage constructs and a method for preparation thereof |
CA2441986A1 (en) | 2001-03-27 | 2002-10-03 | Massachusetts Institute Of Technology | Methods and products related to fgf dimerization |
RU2458067C2 (en) | 2001-05-21 | 2012-08-10 | Омрикс Биофармасьютикалс С.А. | Method of extracting plasminogen or plasmin from mixture in presence of fibrinogen |
CA2447694A1 (en) | 2001-05-25 | 2002-12-05 | Imaging Therapeutics, Inc. | Methods and compositions for articular resurfacing |
GB0115320D0 (en) | 2001-06-22 | 2001-08-15 | Univ Nottingham | Matrix |
US6626950B2 (en) * | 2001-06-28 | 2003-09-30 | Ethicon, Inc. | Composite scaffold with post anchor for the repair and regeneration of tissue |
US6824547B2 (en) | 2001-07-13 | 2004-11-30 | Pilling Weck Incorporated | Endoscopic clip applier and method |
US7201917B2 (en) | 2001-07-16 | 2007-04-10 | Depuy Products, Inc. | Porous delivery scaffold and method |
JP4197158B2 (en) | 2001-07-16 | 2008-12-17 | デピュイ・プロダクツ・インコーポレイテッド | Devices with naturally occurring biologically derived materials |
US20050027307A1 (en) | 2001-07-16 | 2005-02-03 | Schwartz Herbert Eugene | Unitary surgical device and method |
EP1416888A4 (en) | 2001-07-16 | 2007-04-25 | Depuy Products Inc | Meniscus regeneration device and method |
US7819918B2 (en) | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
US7361195B2 (en) | 2001-07-16 | 2008-04-22 | Depuy Products, Inc. | Cartilage repair apparatus and method |
JP2005515802A (en) | 2001-07-16 | 2005-06-02 | デピュイ・プロダクツ・インコーポレイテッド | Hybrid / Synthetic Porous Extracellular Matrix Support Skeleton |
US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US20030033021A1 (en) | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration scaffold and method |
IL144446A0 (en) | 2001-07-19 | 2002-05-23 | Prochon Biotech Ltd | Plasma protein matrices and methods for their preparation |
AU2002355844A1 (en) | 2001-08-01 | 2003-02-17 | New York University | Identification of receptor and heparin binding sites in fgf4 by structure-based mutagenesis |
US8178123B2 (en) | 2001-08-29 | 2012-05-15 | Femina Pharma Incorporated | Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration |
US7132110B2 (en) | 2001-08-30 | 2006-11-07 | Isotis Orthobiologics, Inc. | Tissue repair compositions and methods for their manufacture and use |
JP2005506860A (en) | 2001-09-15 | 2005-03-10 | ラツシユ−プレスビテリアン−セント・リユークズ・メデイカル・センター | Layered cartilage tissue and engineering method thereof |
US6855167B2 (en) | 2001-12-05 | 2005-02-15 | Osteotech, Inc. | Spinal intervertebral implant, interconnections for such implant and processes for making |
US7252987B2 (en) | 2001-12-06 | 2007-08-07 | Islet Technology, Inc. | System for analysis and selection of encapsulated cellular materials |
CA2474269A1 (en) | 2002-01-23 | 2003-07-31 | Institute Of Nutraceutical Research Pty Ltd | Nutraceuticals for the treatment, protection and restoration of connective tissues |
US6852331B2 (en) | 2002-02-11 | 2005-02-08 | Taipei Biotechnology Ltd., Inc. | Fabrication of a cartilage implant |
US6890354B2 (en) | 2002-03-08 | 2005-05-10 | Musculoskeletal Transplant Foundation | Bone-tendon-bone assembly with allograft bone block and method for inserting same |
US20030175410A1 (en) | 2002-03-18 | 2003-09-18 | Campbell Phil G. | Method and apparatus for preparing biomimetic scaffold |
US7468192B2 (en) | 2002-03-22 | 2008-12-23 | Histogenics Corporation | Method for repair of cartilage lesions |
US7537780B2 (en) | 2002-03-22 | 2009-05-26 | Histogenics Corporation | Method for preparing and implanting a cartilage construct to treat cartilage lesions |
NL1020426C2 (en) | 2002-04-18 | 2003-10-21 | Tno | Modification of the properties of a fibrin matrix with respect to cell growth and ingrowth. |
WO2003092542A2 (en) | 2002-05-01 | 2003-11-13 | Verigen Ag | Injectable chondrocyte implant |
IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
WO2003094987A1 (en) | 2002-05-13 | 2003-11-20 | Toshiba Ceramics Co.,Ltd | Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and aritficial cartilage for transplantation |
US7931687B2 (en) | 2002-05-13 | 2011-04-26 | Articular Engineering, Llc | Tissue engineered osteochondral implant |
US7338492B2 (en) | 2002-05-15 | 2008-03-04 | Linvatec Corporation | Cross-pin graft fixation, instruments, and methods |
US6989034B2 (en) | 2002-05-31 | 2006-01-24 | Ethicon, Inc. | Attachment of absorbable tissue scaffolds to fixation devices |
US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
US7291179B2 (en) | 2002-06-24 | 2007-11-06 | Wright Medical Technology, Inc. | Bone graft substitute composition |
US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
US20040166169A1 (en) | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US7264634B2 (en) | 2002-09-20 | 2007-09-04 | Arthrex, Inc. | Method and instrumentation for osteochondral repair using preformed implants |
US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
US7323011B2 (en) | 2002-10-18 | 2008-01-29 | Musculoskeletal Transplant Foundation | Cortical and cancellous allograft cervical fusion block |
US20040078090A1 (en) | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
US7824701B2 (en) | 2002-10-18 | 2010-11-02 | Ethicon, Inc. | Biocompatible scaffold for ligament or tendon repair |
US6761739B2 (en) | 2002-11-25 | 2004-07-13 | Musculoskeletal Transplant Foundation | Cortical and cancellous allograft spacer |
AT500418B1 (en) | 2002-12-05 | 2009-12-15 | Winkler Heinz Dr | CULTIVATED CELLULAR CELLS CONTAINING THE IMPLANT AND METHOD FOR THE PRODUCTION THEREOF |
EP1592373B1 (en) | 2003-01-30 | 2013-04-24 | ProChon Biotech Ltd. | Freeze-dried fibrin matrices and methods for preparation thereof |
US7985414B2 (en) | 2003-02-04 | 2011-07-26 | Warsaw Orthopedic, Inc. | Polyurethanes for osteoimplants |
EP1444995A1 (en) | 2003-02-06 | 2004-08-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | FGF-2 derived proteins for the preparation of biomaterials or medical devices such as stents |
WO2004075940A1 (en) | 2003-02-26 | 2004-09-10 | Zimmer Orthobiologics, Inc. | Preparation for repairing cartilage tissue, especially articular cartilage defects |
US7642092B2 (en) | 2003-03-03 | 2010-01-05 | Technion Research & Development Foundation Ltd. | Cultured cartilage/bone cells/tissue, method of generating same and uses thereof |
US7125423B2 (en) | 2003-03-31 | 2006-10-24 | Depuy Products, Inc. | Intercalary prosthesis, kit and method |
US20050222687A1 (en) | 2004-04-02 | 2005-10-06 | Gordana Vunjak-Novakovic | Cartilage implant assembly and method for implantation |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US20050064042A1 (en) | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7488348B2 (en) | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US20090291112A1 (en) | 2003-05-16 | 2009-11-26 | Truncale Katherine G | Allograft osteochondral plug combined with cartilage particle mixture |
US7537617B2 (en) | 2003-06-05 | 2009-05-26 | Warsaw Orthopedic, Inc. | Bone strip implants and method of making same |
US20070067032A1 (en) | 2003-06-27 | 2007-03-22 | Felt Jeffrey C | Meniscus preserving implant method and apparatus |
AU2004259019B2 (en) | 2003-07-21 | 2010-09-23 | Lifecell Corporation | Acellular tissue matrices made from galactose alpha-1,3-galactose-deficient tissue |
KR101183066B1 (en) | 2003-07-31 | 2012-09-20 | 고이치 나카야마 | Method of constructing artificial joint |
AU2004262451B2 (en) | 2003-08-12 | 2009-11-26 | Tigenix N.V. | Use of CXCL6 chemokine in the prevention or repair of cartilage defects |
US7217294B2 (en) | 2003-08-20 | 2007-05-15 | Histogenics Corp. | Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof |
JP2007503222A (en) | 2003-08-20 | 2007-02-22 | ヒストジェニックス コーポレイション | Non-cellular cartilage or non-cellular matrix embedded in a lesion site of osteochondral, protected by a biodegradable polymer modified to have an extended polymerization time, its preparation and use |
US7226482B2 (en) | 2003-09-02 | 2007-06-05 | Synthes (U.S.A.) | Multipiece allograft implant |
EP1663333B1 (en) | 2003-09-05 | 2018-11-07 | Synthes GmbH | Bone cement compositions having fiber-reinforcement and/or increased flowability |
US20050065613A1 (en) * | 2003-09-24 | 2005-03-24 | Gross Jeffrey M. | Reinforced fusion implant |
EP1677703A4 (en) | 2003-10-02 | 2009-09-02 | Depuy Spine Inc | Chemical treatment for removing cellular and nuclear material from naturally occurring extracellular matrix-based biomaterials |
US20050074476A1 (en) | 2003-10-03 | 2005-04-07 | El Gendler | Cartilidge and bone induction by artificially perforated organic bone matrix augmented by undifferentiated cells suspended in bone gel |
EP1526760A1 (en) | 2003-10-21 | 2005-04-27 | IEE INTERNATIONAL ELECTRONICS & ENGINEERING S.A. | Multiple electroluminescent lamp driver |
GB0325141D0 (en) | 2003-10-28 | 2003-12-03 | Xiros Plc | Repair of damaged tissue on a bone site |
WO2005048897A1 (en) * | 2003-11-18 | 2005-06-02 | Quantum Orthopedics | Osteoconductive integrated spinal cage and method of making same |
US7157428B2 (en) | 2003-11-26 | 2007-01-02 | Histogenics, Corp. | Method for treatment and repair of meniscal injuries |
US7316822B2 (en) | 2003-11-26 | 2008-01-08 | Ethicon, Inc. | Conformable tissue repair implant capable of injection delivery |
US7901461B2 (en) | 2003-12-05 | 2011-03-08 | Ethicon, Inc. | Viable tissue repair implants and methods of use |
US7666230B2 (en) | 2003-12-08 | 2010-02-23 | Depuy Products, Inc. | Implant device for cartilage regeneration in load bearing articulation regions |
ES2403357T3 (en) | 2003-12-11 | 2013-05-17 | Isto Technologies Inc. | Particle Cartilage System |
US11395865B2 (en) | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
US20050196460A1 (en) | 2004-03-08 | 2005-09-08 | Malinin Theodore I. | Particulate cartilage compositions, processes for their preparation and methods for regenerating cartilage |
US20070185585A1 (en) | 2004-03-09 | 2007-08-09 | Brat Bracy | Implant Scaffold Combined With Autologous Tissue, Allogenic Tissue, Cultured Tissue, or combinations Thereof |
JP2007537778A (en) | 2004-03-09 | 2007-12-27 | オステオバイオロジックス, インコーポレイテッド | Graft scaffold in combination with self or allogeneic tissue |
US7648965B2 (en) | 2004-05-14 | 2010-01-19 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
US7531518B2 (en) | 2004-05-14 | 2009-05-12 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
ES2245879B1 (en) | 2004-05-21 | 2006-12-16 | Universidad De Malaga | COMPOSITION FOR OSEA OR CARTILAGINOUS REPAIR. |
US20050288796A1 (en) | 2004-06-23 | 2005-12-29 | Hani Awad | Native soft tissue matrix for therapeutic applications |
US7406210B2 (en) | 2004-06-28 | 2008-07-29 | Xerox Corporation | Darkness control using pattern matching |
US7335508B2 (en) | 2004-07-22 | 2008-02-26 | Prochon Biotech Ltd. | Porous plasma protein matrices and methods for preparation thereof |
MXPA06014403A (en) | 2004-08-20 | 2007-05-08 | Artes Medical Usa Inc | Methods of administering microparticles combined with autologous body components. |
EP1796690A4 (en) | 2004-09-22 | 2011-08-03 | Cartilix Inc | Cartilage filling device |
US8043315B2 (en) | 2004-09-23 | 2011-10-25 | Arthrex, Inc. | Osteochondral repair using plug fashioned from partial distal allograft femur or condyle |
US7273756B2 (en) | 2004-10-01 | 2007-09-25 | Isto Technologies, Inc. | Method for chondrocyte expansion with phenotype retention |
US20080220044A1 (en) | 2007-03-06 | 2008-09-11 | Semler Eric J | Cancellous construct with support ring for repair of osteochondral defects |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20060111778A1 (en) | 2004-10-29 | 2006-05-25 | Michalow Alexander E | Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway |
JP2008521560A (en) | 2004-11-30 | 2008-06-26 | オステオバイオロジクス・インコーポレーテッド | Implant and its delivery system for treating joint surface defects |
SE0403020D0 (en) | 2004-12-13 | 2004-12-13 | Rickard Braanemark | Implant |
US20070041950A1 (en) | 2005-02-01 | 2007-02-22 | Osteobiologics, Inc. | Method and device for selective addition of a bioactive agent to a multi-phase implant |
US7621963B2 (en) | 2005-04-13 | 2009-11-24 | Ebi, Llc | Composite bone graft material |
WO2006113586A2 (en) | 2005-04-15 | 2006-10-26 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
US7291169B2 (en) | 2005-04-15 | 2007-11-06 | Zimmer Technology, Inc. | Cartilage implant |
US8506646B2 (en) | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
US20060247790A1 (en) | 2005-04-30 | 2006-11-02 | Mckay William F | Shaped osteochondral grafts and methods of using same |
WO2006121612A1 (en) | 2005-05-05 | 2006-11-16 | Isto Technologies, Inc. | Treatment of joint disease, methods and apparatuses therefor |
US8092548B2 (en) * | 2005-06-22 | 2012-01-10 | Warsaw Orthopedic, Inc. | Osteograft treatment to promote osteoinduction and osteograft incorporation |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
US20070010824A1 (en) | 2005-07-11 | 2007-01-11 | Hugues Malandain | Products, systems and methods for delivering material to bone and other internal body parts |
US7638486B2 (en) | 2005-07-18 | 2009-12-29 | Acologix, Inc. | Method for promoting hard tissue formation |
US20070026030A1 (en) | 2005-07-27 | 2007-02-01 | Berkeley Advanced Biomaterials, Inc. | Method of preparing rheological materials for bone and cartilage repair |
EP1916964A4 (en) | 2005-08-26 | 2015-11-04 | Zimmer Inc | Implants and methods for repair, replacement and treatment of joint disease |
US7927630B2 (en) | 2005-09-12 | 2011-04-19 | Johnson Lanny L | Use of autologous sediment from fluid aspirates as vehicles for drug delivery |
AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
US9132208B2 (en) | 2008-08-07 | 2015-09-15 | Lifenet Health | Composition for a tissue repair implant and methods of making the same |
US8029575B2 (en) | 2005-10-25 | 2011-10-04 | Globus Medical, Inc. | Porous and nonporous materials for tissue grafting and repair |
US7371260B2 (en) | 2005-10-26 | 2008-05-13 | Biomet Sports Medicine, Inc. | Method and instrumentation for the preparation and transplantation of osteochondral allografts |
US8403985B2 (en) | 2005-11-02 | 2013-03-26 | Zimmer, Inc. | Joint spacer implant |
TWI274591B (en) | 2005-11-07 | 2007-03-01 | Univ Tsinghua | Composite scaffold for remedying articular cartilage tissue and preparation thereof |
EP1951158A4 (en) | 2005-11-21 | 2010-03-31 | Vertegen Inc | Devices and methods for treating facet joints, uncovertebral joints, costovertebral joints and other joints |
US20070129630A1 (en) | 2005-12-07 | 2007-06-07 | Shimko Daniel A | Imaging method, device and system |
EP1973554B1 (en) | 2005-12-07 | 2015-01-14 | Isto Technologies Inc. | Cartilage repair methods |
TWI316860B (en) | 2005-12-29 | 2009-11-11 | Ind Tech Res Inst | Multi-layered matrix, method of tissue repair using the same and multi-layered implant prepared thereof |
US8070810B2 (en) | 2006-01-12 | 2011-12-06 | Histogenics Corporation | Method for repair and reconstruction of ruptured ligaments or tendons and for treatment of ligament and tendon injuries |
US7833269B2 (en) | 2006-01-25 | 2010-11-16 | Warsaw Orthopedic, Inc | Osteochondral implant procedure |
US20070179607A1 (en) | 2006-01-31 | 2007-08-02 | Zimmer Technology, Inc. | Cartilage resurfacing implant |
DE102006006904A1 (en) | 2006-02-09 | 2007-08-23 | Universität Rostock | New haemostatic agents and adhesives for medical applications |
US7416889B2 (en) | 2006-04-27 | 2008-08-26 | Rhode Island Hospital | Methods and compositions for repairing cartilage |
US7838022B2 (en) | 2006-05-01 | 2010-11-23 | Warsaw Orthopedic, Inc | Malleable implants containing demineralized bone matrix |
US20070276506A1 (en) | 2006-05-25 | 2007-11-29 | Biomet Manufacturing Corp. | Demineralized osteochondral plug |
US20070299517A1 (en) | 2006-06-21 | 2007-12-27 | Howmedica Osteonics Corp. | Articular cartilage implant |
WO2008013763A2 (en) | 2006-07-25 | 2008-01-31 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
CN101332314B (en) | 2008-07-22 | 2012-11-14 | 广东冠昊生物科技股份有限公司 | Biotype articular cartilage repair piece |
WO2008021127A2 (en) | 2006-08-08 | 2008-02-21 | Howmedica Osteonics Corp. | Expandable cartilage implant |
US9066994B2 (en) * | 2006-08-31 | 2015-06-30 | Warsaw Orthopedic, Inc. | Demineralized cancellous strip DBM graft |
US8449622B2 (en) | 2006-09-11 | 2013-05-28 | Warsaw Orthopedic, Inc. | Multi-phase osteochondral implantable device |
WO2008038287A2 (en) | 2006-09-28 | 2008-04-03 | Hepacore Ltd. | N-terminal fgf variants having increased receptor selectivity and uses thereof |
WO2008045212A2 (en) | 2006-10-06 | 2008-04-17 | Kyphon Sarl | Products and methods for percutaneous material delivery |
GB0623065D0 (en) | 2006-11-18 | 2006-12-27 | Smith & Nephew | Annular ring |
US20080125863A1 (en) | 2006-11-28 | 2008-05-29 | Mckay William F | Implant designs and methods of improving cartilage repair |
US20080138414A1 (en) | 2006-12-08 | 2008-06-12 | Smith & Nephew, Inc. | Methods of Regenerating Cartilage |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
US20080154372A1 (en) | 2006-12-21 | 2008-06-26 | Peckham Steven M | Osteochondral implant using a growth factor concentration gradient for repair of bone and cartilage tissue |
WO2008081463A2 (en) | 2007-01-04 | 2008-07-10 | Hepacore Ltd. | Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof |
US7758643B2 (en) * | 2007-02-26 | 2010-07-20 | Biomet Sports Medicine, Llc | Stable cartilage defect repair plug |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US20090012629A1 (en) | 2007-04-12 | 2009-01-08 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
US20080279825A1 (en) | 2007-05-10 | 2008-11-13 | Malinin Theodore I | Cartilage material |
US20080294270A1 (en) * | 2007-05-24 | 2008-11-27 | Zimmer Orthobiologics, Inc. | Differentially processed tissue and processing methods thereof |
US8574825B2 (en) | 2007-06-01 | 2013-11-05 | Bacterin International, Inc. | Process for demineralization of bone matrix with preservation of natural growth factors |
US9744043B2 (en) | 2007-07-16 | 2017-08-29 | Lifenet Health | Crafting of cartilage |
US20090081276A1 (en) | 2007-08-13 | 2009-03-26 | Eben Alsberg | Bioresorbable implant composition |
US8685099B2 (en) | 2007-08-14 | 2014-04-01 | Warsaw Orthopedic, Inc. | Multiple component osteoimplant |
US9486317B2 (en) | 2007-08-27 | 2016-11-08 | Arthrex Inc. | Method of arthroscopic osteochondral resurfacing using PRP strengthened with fibrin glue |
US20090069904A1 (en) | 2007-09-12 | 2009-03-12 | Applied Medical Research | Biomaterial including micropores |
US8641774B2 (en) | 2007-09-14 | 2014-02-04 | The Curators Of The University Of Missouri | Synthetic osteochondral composite and method of fabrication thereof |
US8202539B2 (en) | 2007-10-19 | 2012-06-19 | Warsaw Orthopedic, Inc. | Demineralized bone matrix compositions and methods |
WO2009067486A2 (en) | 2007-11-19 | 2009-05-28 | David Lee | Method and apparatus for spinal facet joint fusion using irregularly shaped cortical bone implants |
EP2224884A2 (en) | 2007-12-05 | 2010-09-08 | Musculoskeletal Transplant Foundation | Cancellous bone implant for cartilage repair |
US9700584B2 (en) | 2007-12-21 | 2017-07-11 | Rti Surgical, Inc. | Osteoinductive putties and methods of making and using such putties |
CA2717725A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US8043375B2 (en) | 2008-03-06 | 2011-10-25 | MoiRai Orthopaedic, LLC | Cartilage implants |
EP2257176B1 (en) | 2008-03-14 | 2013-09-18 | Regenerative Sciences, LLC | Compositions and methods for cartilage repair |
JP2009291304A (en) | 2008-06-03 | 2009-12-17 | Gc Corp | Bone graft substitute |
US20090312842A1 (en) | 2008-06-16 | 2009-12-17 | Predrag Bursac | Assembled Cartilage Repair Graft |
WO2010005917A2 (en) | 2008-07-06 | 2010-01-14 | The Curators Of The University Of Missouri | Osteochondral implants, arthroplasty methods, devices, and systems |
WO2010083051A2 (en) | 2009-01-15 | 2010-07-22 | ProChon Biotech, Ltd. | Cartilage particle tissue mixtures optionally combined with a cancellous construct |
US8556972B2 (en) | 2009-04-02 | 2013-10-15 | Sevika Holding AG | Monolithic orthopedic implant with an articular finished surface |
US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US20120283833A1 (en) | 2009-12-04 | 2012-11-08 | Brannon James K | Articular cartilage treatment method |
US8597317B2 (en) | 2009-12-11 | 2013-12-03 | Taipei Medical University | Method for repair of articular cartilage defect and a device used therein |
US9155607B2 (en) | 2011-11-16 | 2015-10-13 | Purdue Research Foundation | Compositions and methods for repair or regeneration of soft tissue |
US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
BR112014014975B1 (en) | 2011-12-20 | 2019-06-25 | Lifecell Corporation | A method of producing a fabric composition |
ES2729712T3 (en) | 2011-12-20 | 2019-11-05 | Lifecell Corp | Sheet fabric products |
US9198758B2 (en) | 2012-01-26 | 2015-12-01 | Warsaw Orthopedic, Inc. | Delivery systems |
US10207027B2 (en) | 2012-06-11 | 2019-02-19 | Globus Medical, Inc. | Bioactive bone graft substitutes |
US9655994B2 (en) | 2012-07-25 | 2017-05-23 | William F. McKay | Delivery systems |
-
2007
- 2007-01-24 US US11/657,042 patent/US7837740B2/en active Active
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2008
- 2008-01-23 WO PCT/US2008/051796 patent/WO2008106254A2/en active Application Filing
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- 2010-09-14 US US12/881,988 patent/US8906110B2/en active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112704588A (en) * | 2020-12-21 | 2021-04-27 | 济宁医学院附属医院 | Personalized customized articular cartilage injury repair device based on 3D printing |
CN112704588B (en) * | 2020-12-21 | 2022-07-29 | 济宁医学院附属医院 | Individualized customization articular cartilage damage prosthetic devices based on 3D prints |
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WO2008106254A3 (en) | 2009-07-30 |
US20110224797A1 (en) | 2011-09-15 |
EP2162094A2 (en) | 2010-03-17 |
US7837740B2 (en) | 2010-11-23 |
CA2675170C (en) | 2014-09-30 |
US8906110B2 (en) | 2014-12-09 |
WO2008106254A2 (en) | 2008-09-04 |
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