CA2651855A1 - Two-piece, internal-channel osmotic delivery system flow modulator - Google Patents
Two-piece, internal-channel osmotic delivery system flow modulator Download PDFInfo
- Publication number
- CA2651855A1 CA2651855A1 CA002651855A CA2651855A CA2651855A1 CA 2651855 A1 CA2651855 A1 CA 2651855A1 CA 002651855 A CA002651855 A CA 002651855A CA 2651855 A CA2651855 A CA 2651855A CA 2651855 A1 CA2651855 A1 CA 2651855A1
- Authority
- CA
- Canada
- Prior art keywords
- flow modulator
- reservoir
- outer shell
- delivery system
- inner core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
- Y10T137/0402—Cleaning, repairing, or assembling
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49229—Prime mover or fluid pump making
- Y10T29/49236—Fluid pump or compressor making
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/494—Fluidic or fluid actuated device making
Abstract
An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening of a reservoir of an osmotic delivery system, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
Claims (20)
1. An osmotic delivery system flow modulator, comprising:
an outer shell constructed and arranged for positioning in an opening of a reservoir of an osmotic delivery system;
an inner core inserted in the outer shell; and a fluid channel having a spiral shape defined between the outer shell and the inner core, the fluid channel being adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
an outer shell constructed and arranged for positioning in an opening of a reservoir of an osmotic delivery system;
an inner core inserted in the outer shell; and a fluid channel having a spiral shape defined between the outer shell and the inner core, the fluid channel being adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
2. The flow modulator of claim 1, wherein the fluid channel is formed on an outer surface of the inner core which mates with an inner surface of the outer shell.
3. The flow modulator of claim 1, wherein the fluid channel is formed on an inner surface of the outer shell which mates with an outer surface of the inner core.
4. The flow modulator of claim 1, further comprising a flow insert disposed between the outer shell and inner core, wherein the fluid channel is formed in the flow insert.
5. The flow modulator of claim 4, wherein the outer shell, inner core, and flow insert are made of an inert material.
6. The flow modulator of claim 5, wherein the inert material is a non-metallic material.
7. The flow modulator of claim 1, wherein the outer shell and inner core are made of an inert material.
8. The flow modulator of claim 7, wherein the inert material is a non-metallic material.
9. The flow modulator of claim 1, wherein the outer shell sealingly engages the inner core.
10. The flow modulator of claim 1, wherein the inner core includes an outer shoulder and the outer shell includes an inner shoulder, wherein the outer shoulder and inner shoulder engage to prevent expulsion of the inner core from the outer shell in use.
11. The flow modulator of claim 1, wherein a length of the fluid channel ranges from 10 to 50 mm.
12. The flow modulator of claim 1, wherein an effective cross-sectional diameter of the fluid channel ranges from 0.1 to 0.5 mm.
13. An osmotic delivery system, comprising:
a reservoir;
a semipermeable plug disposed at a first end of the reservoir to selectively permit fluid flow into the reservoir; and a flow modulator disposed at a second end of the reservoir, the flow modulator comprising an internal spiral channel adapted for delivery of an active agent formulation contained in the reservoir to a fluid environment in which the osmotic delivery system operates.
a reservoir;
a semipermeable plug disposed at a first end of the reservoir to selectively permit fluid flow into the reservoir; and a flow modulator disposed at a second end of the reservoir, the flow modulator comprising an internal spiral channel adapted for delivery of an active agent formulation contained in the reservoir to a fluid environment in which the osmotic delivery system operates.
14. The osmotic delivery system of claim 13, wherein the flow modulator comprises an outer shell and an inner core inserted in the outer shell, wherein the spiral channel is defined between the outer shell and the inner core.
15. The osmotic delivery system of claim 14, wherein the flow modulator is press-fitted into the second end of the reservoir.
16. The osmotic delivery system of claim 14, further comprising a partition disposed and movable within the reservoir, the partition defining a first chamber containing an osmotic engine and a second chamber containing the active agent formulation, wherein the first chamber is adjacent the semipermeable plug and the second chamber is adjacent the flow modulator.
17. The osmotic delivery system of claim 13, wherein the active agent formulation comprises interferon-omega.
18. An implantable delivery system for an active agent formulation, comprising:
a reservoir made of an impermeable material;
a first chamber in the reservoir containing an osmotic engine;
a second chamber in the reservoir containing an active agent formulation;
a semipermeable plug disposed at a first end of the reservoir adjacent the first chamber; and a flow modulator according to any of claims 1-12 disposed at a second end of the reservoir adjacent the second chamber.
a reservoir made of an impermeable material;
a first chamber in the reservoir containing an osmotic engine;
a second chamber in the reservoir containing an active agent formulation;
a semipermeable plug disposed at a first end of the reservoir adjacent the first chamber; and a flow modulator according to any of claims 1-12 disposed at a second end of the reservoir adjacent the second chamber.
19. The implantable delivery system of claim 18, wherein the active agent formulation comprises interferon-omega.
20. The implantable delivery system of claim 18, further comprising a partition between the osmotic engine and the active agent formulation.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80945106P | 2006-05-30 | 2006-05-30 | |
US60/809,451 | 2006-05-30 | ||
PCT/US2007/069990 WO2007140416A2 (en) | 2006-05-30 | 2007-05-30 | Two-piece, internal-channel osmotic delivery system flow modulator |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2651855A1 true CA2651855A1 (en) | 2007-12-06 |
CA2651855C CA2651855C (en) | 2011-08-02 |
Family
ID=38617914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2651855A Active CA2651855C (en) | 2006-05-30 | 2007-05-30 | Two-piece, internal-channel osmotic delivery system flow modulator |
Country Status (16)
Country | Link |
---|---|
US (8) | US8052996B2 (en) |
EP (1) | EP2020990B1 (en) |
JP (1) | JP5143131B2 (en) |
KR (1) | KR101106510B1 (en) |
CN (1) | CN101453982B (en) |
AT (1) | ATE481963T1 (en) |
AU (1) | AU2007266475B2 (en) |
CA (1) | CA2651855C (en) |
DE (1) | DE602007009377D1 (en) |
DK (1) | DK2020990T3 (en) |
ES (1) | ES2351527T3 (en) |
HK (1) | HK1129203A1 (en) |
IL (1) | IL194746A (en) |
MX (1) | MX2008014870A (en) |
NZ (1) | NZ572003A (en) |
WO (1) | WO2007140416A2 (en) |
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