CA2638743A1 - Transdermal patch incorporating active agent migration barrier layer - Google Patents
Transdermal patch incorporating active agent migration barrier layer Download PDFInfo
- Publication number
- CA2638743A1 CA2638743A1 CA002638743A CA2638743A CA2638743A1 CA 2638743 A1 CA2638743 A1 CA 2638743A1 CA 002638743 A CA002638743 A CA 002638743A CA 2638743 A CA2638743 A CA 2638743A CA 2638743 A1 CA2638743 A1 CA 2638743A1
- Authority
- CA
- Canada
- Prior art keywords
- layer
- active agent
- release liner
- outer layer
- impermeable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
Abstract
Devices (100) for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch (100).
One outer layer (110) functions as the primary adhesive layer for adhering the patch (100) to the host. The other inner layer (122) contains at least one active agent to be administered to the host. The inner layer (122) is bonded to the outer layer (110) through an opening (114) provided in an interposed active agent impermeable release layer (104). The release layer (104) separates a circumferential portion of the active agent containing inner layer (122) from the outer adhesive layer (220) to inhibit migration of the active agent therebetween.
One outer layer (110) functions as the primary adhesive layer for adhering the patch (100) to the host. The other inner layer (122) contains at least one active agent to be administered to the host. The inner layer (122) is bonded to the outer layer (110) through an opening (114) provided in an interposed active agent impermeable release layer (104). The release layer (104) separates a circumferential portion of the active agent containing inner layer (122) from the outer adhesive layer (220) to inhibit migration of the active agent therebetween.
Claims (8)
1. A method for inhibiting migration of an active agent from an active agent inner layer into an adhesive outer layer within an active agent release device prior to adhering the device to the skin or mucosa of a host, said inner layer having an active agent impermeable layer, said method comprising adhering a release liner to a first portion of the outer layer; and adhering a portion of the impermeable layer of the inner layer to a second portion of the outer layer, whereby a remaining portion of the impermeable layer is arranged overlying the release liner, said release liner separating a peripheral portion of the inner layer from the outer layer until removal of the release liner.
2. The method of claim 1, wherein said release liner comprises an active agent impermeable material.
3. The method of claim 1, further including releasably adhering said release liner to said outer layer.
4. The method of claim 1, further including providing an opening within said release liner, and exposing a portion of said outer layer within said opening.
5. The method of claim 4, wherein said portion of said impermeable layer is adhered to said second portion of said outer layer within said opening of said release liner.
6. The method of claim 4, wherein said remaining portion of said impermeable layer circumscribes said opening of said release liner.
7. The method of claim 1, wherein said active agent impermeable layer is at least co-extensive with said inner layer.
8. The method of claim 1, wherein said release liner has a bottom surface releasably adhered to said outer layer and a top surface unadhered underlying said active agent impermeable layer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/641,654 US8524272B2 (en) | 2003-08-15 | 2003-08-15 | Transdermal patch incorporating active agent migration barrier layer |
US10/641,654 | 2003-08-15 | ||
CA2531504A CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2531504A Division CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2638743A1 true CA2638743A1 (en) | 2005-03-03 |
CA2638743C CA2638743C (en) | 2012-05-22 |
Family
ID=34136410
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002637297A Expired - Fee Related CA2637297C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2637321A Expired - Fee Related CA2637321C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2637849A Expired - Fee Related CA2637849C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2708347A Expired - Fee Related CA2708347C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2638743A Expired - Fee Related CA2638743C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2531504A Expired - Fee Related CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002637297A Expired - Fee Related CA2637297C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2637321A Expired - Fee Related CA2637321C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2637849A Expired - Fee Related CA2637849C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2708347A Expired - Fee Related CA2708347C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2531504A Expired - Fee Related CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Country Status (7)
Country | Link |
---|---|
US (3) | US8524272B2 (en) |
EP (1) | EP1653897A4 (en) |
JP (1) | JP4388068B2 (en) |
AU (1) | AU2004266563B2 (en) |
CA (6) | CA2637297C (en) |
MX (1) | MXPA06001783A (en) |
WO (1) | WO2005018517A1 (en) |
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BRPI0407615B8 (en) * | 2003-02-21 | 2021-05-25 | Bayer Ip Gmbh | UV stable transdermal therapeutic system |
US8535711B2 (en) * | 2004-01-23 | 2013-09-17 | Teikoku Pharma Usa, Inc. | Medication disposal system |
US7867511B2 (en) | 2004-01-23 | 2011-01-11 | Travanti Pharma Inc. | Abuse potential reduction in abusable substance dosage form |
US20060188558A1 (en) * | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
PL1895994T3 (en) | 2005-05-13 | 2011-02-28 | Alza Corp | Multilayer drug delivery system with barrier against reservoir material flow |
EP1898891A2 (en) * | 2005-05-13 | 2008-03-19 | Alza Corporation | Multilayer drug delivery system with barrier against antagonist exposure |
EP1928881A2 (en) | 2005-08-19 | 2008-06-11 | Pharmacofore, Inc. | Prodrugs of active agents |
US7955677B2 (en) * | 2005-12-07 | 2011-06-07 | Mylan Technologies, Inc. | Two-sided non-stick release film |
MX2008014794A (en) | 2006-05-26 | 2009-04-08 | Pharmacofore Inc | Controlled release of phenolic opioids. |
EP2047335B1 (en) * | 2006-07-25 | 2011-05-11 | Hewlett-Packard Development Company, L.P. | Methods of producing ink toners |
DE102006054733A1 (en) | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with high drug utilization rate and dosing accuracy |
DE102007025973A1 (en) * | 2007-06-04 | 2008-12-11 | Lts Lohmann Therapie-Systeme Ag | Storage stable laminate sections |
JP5394083B2 (en) | 2008-02-06 | 2014-01-22 | 日東電工株式会社 | Patch packaging structure |
DE102011080390B3 (en) * | 2011-08-03 | 2012-07-12 | Acino Ag | application aid |
WO2013049380A1 (en) | 2011-09-30 | 2013-04-04 | Teikoku Pharma Usa, Inc. | Transdermal patch disposal system |
KR20140067042A (en) | 2011-09-30 | 2014-06-03 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | General medication disposal system |
CN105287440A (en) * | 2014-06-18 | 2016-02-03 | 杨宁正 | Permeation type pharmaceutic thin film patch |
US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
GB2556817B (en) | 2015-10-01 | 2019-11-06 | Elysium Therapeutics Inc | Polysubunit opioid prodrugs resistant to overdose and abuse |
US10076473B2 (en) * | 2016-02-15 | 2018-09-18 | C&Tech Corporation | Apparatus and method for manufacturing dried gel sheet and gel sheet or beauty pack manufactured by the same |
JP7234130B2 (en) | 2017-03-17 | 2023-03-07 | エリージウム セラピューティクス, インコーポレイテッド | Polysubunit opioid prodrugs resistant to overdose and abuse |
US20190015352A1 (en) * | 2017-07-14 | 2019-01-17 | Pendleton Brewster Wickersham | Applicators & Patches for Dermal & Transdermal Treatment Material & Drug Delivery, Methods of Making Them, & Methods of Use |
US11389844B2 (en) | 2018-03-20 | 2022-07-19 | Verde Environmental Technologies, Inc. | Blister pack disposal system |
USD999385S1 (en) | 2021-10-18 | 2023-09-19 | Dbv Technologies | Patch assembly |
USD999384S1 (en) | 2021-10-18 | 2023-09-19 | Dbv Technologies | Patch assembly |
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-
2003
- 2003-08-15 US US10/641,654 patent/US8524272B2/en active Active
-
2004
- 2004-01-26 CA CA002637297A patent/CA2637297C/en not_active Expired - Fee Related
- 2004-01-26 CA CA2637321A patent/CA2637321C/en not_active Expired - Fee Related
- 2004-01-26 CA CA2637849A patent/CA2637849C/en not_active Expired - Fee Related
- 2004-01-26 CA CA2708347A patent/CA2708347C/en not_active Expired - Fee Related
- 2004-01-26 EP EP04705280A patent/EP1653897A4/en not_active Withdrawn
- 2004-01-26 MX MXPA06001783A patent/MXPA06001783A/en active IP Right Grant
- 2004-01-26 WO PCT/US2004/002105 patent/WO2005018517A1/en active Application Filing
- 2004-01-26 JP JP2006523817A patent/JP4388068B2/en not_active Expired - Fee Related
- 2004-01-26 CA CA2638743A patent/CA2638743C/en not_active Expired - Fee Related
- 2004-01-26 AU AU2004266563A patent/AU2004266563B2/en not_active Ceased
- 2004-01-26 CA CA2531504A patent/CA2531504C/en not_active Expired - Fee Related
-
2013
- 2013-06-13 US US13/916,712 patent/US8802136B2/en not_active Expired - Lifetime
-
2014
- 2014-05-15 US US14/278,486 patent/US9358373B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20050037059A1 (en) | 2005-02-17 |
AU2004266563A1 (en) | 2005-03-03 |
EP1653897A4 (en) | 2012-03-21 |
EP1653897A1 (en) | 2006-05-10 |
CA2638743C (en) | 2012-05-22 |
WO2005018517A1 (en) | 2005-03-03 |
AU2004266563B2 (en) | 2011-03-10 |
CA2531504A1 (en) | 2005-03-03 |
CA2637849A1 (en) | 2005-03-03 |
JP4388068B2 (en) | 2009-12-24 |
US8802136B2 (en) | 2014-08-12 |
CA2637321C (en) | 2010-04-13 |
MXPA06001783A (en) | 2006-05-04 |
US9358373B2 (en) | 2016-06-07 |
CA2637321A1 (en) | 2005-03-03 |
CA2708347A1 (en) | 2005-03-03 |
US20140249492A1 (en) | 2014-09-04 |
CA2637297C (en) | 2009-07-21 |
JP2007502649A (en) | 2007-02-15 |
US20130274694A1 (en) | 2013-10-17 |
CA2637849C (en) | 2010-04-13 |
US8524272B2 (en) | 2013-09-03 |
CA2637297A1 (en) | 2005-03-03 |
CA2531504C (en) | 2011-04-12 |
CA2708347C (en) | 2012-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20220126 |