CA2637849A1 - Transdermal patch incorporating active agent migration barrier layer - Google Patents

Transdermal patch incorporating active agent migration barrier layer Download PDF

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Publication number
CA2637849A1
CA2637849A1 CA002637849A CA2637849A CA2637849A1 CA 2637849 A1 CA2637849 A1 CA 2637849A1 CA 002637849 A CA002637849 A CA 002637849A CA 2637849 A CA2637849 A CA 2637849A CA 2637849 A1 CA2637849 A1 CA 2637849A1
Authority
CA
Canada
Prior art keywords
active agent
liner
outer layer
layer
host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002637849A
Other languages
French (fr)
Other versions
CA2637849C (en
Inventor
Kenneth J. Ii Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Technologies Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2637849A1 publication Critical patent/CA2637849A1/en
Application granted granted Critical
Publication of CA2637849C publication Critical patent/CA2637849C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)

Abstract

Devices (100) for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch (100).
One outer layer (110) functions as the primary adhesive layer for adhering the patch (100) to the host. The other inner layer (122) contains at least one active agent to be administered to the host. The inner layer (122) is bonded to the outer layer (110) through an opening (114) provided in an interposed active agent impermeable release layer (104). The release layer (104) separates a circumferential portion of the active agent containing inner layer (122) from the outer adhesive layer (220) to inhibit migration of the active agent therebetween.

Claims (18)

  1. THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
    PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
    l. A device for the release of an active agent to the skin or mucosa of a host, said device comprising an outer layer having top and bottom surfaces, said top surface of said outer layer having adhesive properties adapted for adhering said outer layer to the skin or mucosa of a host; a liner releasably adhered to said top surface of said outer layer, said liner having an opening exposing a portion of said top surface of said outer layer; an active agent inner layer having an active agent overlying said liner, said inner layer having a surface area smaller than a surface area of said outer layer and greater than a surface area of said opening in said liner; and an active agent impermeable layer adhered to said bottom surface of said inner layer, said impermeable layer having a portion thereof adhered to said top surface of said outer layer within said opening in said liner, whereby a portion of said liner is interposed between a portion of said inner layer and a portion of said outer layer to inhibit migration of said active agent from said inner layer to said outer layer prior to adhering said device to the skin or mucosa of a host upon removal of said liner.
  2. 2. The device of claim 1, wherein said outer layer comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
  3. 3. The device of claim 1, wherein said outer layer includes an active agent to be administered to the skin or mucosa of a host.
  4. 4. The device of claim 1, wherein said liner comprises an active agent impermeable material.
  5. 5. The device of claim 1, wherein said active agent inner layer includes a circumferential portion surrounding said opening within said liner, said circumferential portion separated from said top surface of said outer layer by said liner interposed therebetween.
  6. 6. The device of claim 1, wherein said active agent inner layer comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
  7. 7. The device of claim 1, further including a layer of active agent permeable adhesive applied overlying said active agent inner layer for adhering said device to the skin or mucosa of a host.
  8. 8. The device of claim 1, further including a release liner releasably adhered to said active agent inner layer.
  9. 9. The device of claim 1, wherein said active agent impermeable layer is at least co-extensive with the bottom surface of said inner layer.
  10. 10. A method of making a device for the release of an active agent to the skin or mucosa of a host, said method comprising providing an outer layer having top and bottom surfaces, said top surface of said outer layer having adhesive properties adapted for adhering said outer layer to the skin or mucosa of a host;
    releasably adhering a liner to said top surface of said outer layer, said liner having an opening exposing a portion of said top surface of said outer layer; positioning an active agent inner layer having an active agent impermeable layer overlying said liner, said inner layer having a surface area smaller than a surface area of said outer layer and greater than a surface area of said opening in said liner; and adhering a portion of said impermeable layer to said top surface of said outer layer within said opening in said liner, whereby a portion of said liner is interposed between a portion of said inner layer and a portion of said outer layer to inhibit migration of said active agent from said inner layer to said outer layer prior to adhering said device to the skin or mucosa of a host upon removal of said liner.
  11. 11. The method of claim 10, wherein said outer layer comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
  12. 12. The method of claim 10, wherein said outer layer includes an active agent to be administered to the skin or mucosa of a host.
  13. 13. The method of claim 10, wherein said liner comprises an active agent impermeable material.
  14. 14. The method of claim 10, wherein said active agent inner layer includes a circumferential portion surrounding said opening within said liner, said circumferential portion separated from said top surface of said outer layer by said liner interposed therebetween.
  15. 15. The method of claim 10, wherein said active agent inner layer comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
  16. 16. The method of claim 10, further including a layer of active agent permeable adhesive applied overlying said active agent inner layer for adhering said device to the skin or mucosa of a host.
  17. 17. The method of claim 10, further including a release liner releasably adhered to said active agent inner layer.
  18. 18. The method of claim 10, wherein said active agent impermeable layer is at least co-extensive with the bottom surface of said inner layer.
CA2637849A 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer Expired - Fee Related CA2637849C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/641,654 US8524272B2 (en) 2003-08-15 2003-08-15 Transdermal patch incorporating active agent migration barrier layer
US10/641,654 2003-08-15
CA2531504A CA2531504C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2531504A Division CA2531504C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer

Publications (2)

Publication Number Publication Date
CA2637849A1 true CA2637849A1 (en) 2005-03-03
CA2637849C CA2637849C (en) 2010-04-13

Family

ID=34136410

Family Applications (6)

Application Number Title Priority Date Filing Date
CA2708347A Expired - Fee Related CA2708347C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer
CA2637321A Expired - Fee Related CA2637321C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer
CA2638743A Expired - Fee Related CA2638743C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer
CA002637297A Expired - Fee Related CA2637297C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer
CA2637849A Expired - Fee Related CA2637849C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer
CA2531504A Expired - Fee Related CA2531504C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer

Family Applications Before (4)

Application Number Title Priority Date Filing Date
CA2708347A Expired - Fee Related CA2708347C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer
CA2637321A Expired - Fee Related CA2637321C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer
CA2638743A Expired - Fee Related CA2638743C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer
CA002637297A Expired - Fee Related CA2637297C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2531504A Expired - Fee Related CA2531504C (en) 2003-08-15 2004-01-26 Transdermal patch incorporating active agent migration barrier layer

Country Status (7)

Country Link
US (3) US8524272B2 (en)
EP (1) EP1653897A4 (en)
JP (1) JP4388068B2 (en)
AU (1) AU2004266563B2 (en)
CA (6) CA2708347C (en)
MX (1) MXPA06001783A (en)
WO (1) WO2005018517A1 (en)

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Also Published As

Publication number Publication date
CA2637321A1 (en) 2005-03-03
CA2531504C (en) 2011-04-12
CA2638743C (en) 2012-05-22
CA2637297C (en) 2009-07-21
JP4388068B2 (en) 2009-12-24
AU2004266563A1 (en) 2005-03-03
EP1653897A1 (en) 2006-05-10
US9358373B2 (en) 2016-06-07
CA2637297A1 (en) 2005-03-03
CA2637321C (en) 2010-04-13
CA2708347C (en) 2012-12-18
CA2708347A1 (en) 2005-03-03
US20050037059A1 (en) 2005-02-17
WO2005018517A1 (en) 2005-03-03
EP1653897A4 (en) 2012-03-21
MXPA06001783A (en) 2006-05-04
US20130274694A1 (en) 2013-10-17
AU2004266563B2 (en) 2011-03-10
CA2531504A1 (en) 2005-03-03
US20140249492A1 (en) 2014-09-04
CA2637849C (en) 2010-04-13
CA2638743A1 (en) 2005-03-03
US8524272B2 (en) 2013-09-03
JP2007502649A (en) 2007-02-15
US8802136B2 (en) 2014-08-12

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Effective date: 20220126