CA2637321A1 - Transdermal patch incorporating active agent migration barrier layer - Google Patents
Transdermal patch incorporating active agent migration barrier layer Download PDFInfo
- Publication number
- CA2637321A1 CA2637321A1 CA002637321A CA2637321A CA2637321A1 CA 2637321 A1 CA2637321 A1 CA 2637321A1 CA 002637321 A CA002637321 A CA 002637321A CA 2637321 A CA2637321 A CA 2637321A CA 2637321 A1 CA2637321 A1 CA 2637321A1
- Authority
- CA
- Canada
- Prior art keywords
- layer
- active agent
- host
- mucosa
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Materials For Medical Uses (AREA)
Abstract
Devices (100) for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch (100).
One outer layer (110) functions as the primary adhesive layer for adhering the patch (100) to the host. The other inner layer (122) contains at least one active agent to be administered to the host. The inner layer (122) is bonded to the outer layer (110) through an opening (114) provided in an interposed active agent impermeable release layer (104). The release layer (104) separates a circumferential portion of the active agent containing inner layer (122) from the outer adhesive layer (220) to inhibit migration of the active agent therebetween.
One outer layer (110) functions as the primary adhesive layer for adhering the patch (100) to the host. The other inner layer (122) contains at least one active agent to be administered to the host. The inner layer (122) is bonded to the outer layer (110) through an opening (114) provided in an interposed active agent impermeable release layer (104). The release layer (104) separates a circumferential portion of the active agent containing inner layer (122) from the outer adhesive layer (220) to inhibit migration of the active agent therebetween.
Claims (23)
1. A device for the release of an active agent to the skin or mucosa or a host, said device comprising a first layer having adhesive properties adapted for adhering said first layer to the skin or mucosa of a host; a second layer releasably adhered to said first layer, said second layer having an opening exposing a portion of said first layer; and a third layer overlying said second layer, said third layer including an active agent impermeable layer having a portion thereof adhered to said first layer within said opening in said second layer, said second layer separating a portion of said third layer from said first layer prior to removal of said second layer when adhering said device to the skin or mucosa of a host by said first layer.
2. The device of claim 1, wherein at least one of said first layer and said third layer includes an active agent to be administered to the skin or mucosa of a host.
3. The device of claim 1, wherein said second layer comprises an active agent impermeable material.
4. The device of claim 1, wherein said third layer includes a circumferential portion surrounding said opening within said second layer, said circumferential portion separated from said first layer by said second layer interposed therebetween.
5. The device of claim 1, wherein said second layer includes at least one slot extending from an edge of said second layer to said opening.
6. The device of claim 1, wherein said first layer comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
7. The device of claim 1, further including a layer of active agent impermeable material releasably applied overlying said third layer.
8. The device of claim 1, wherein said third layer comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
9. The device of claim 1, further including a layer of active agent permeable adhesive applied overlying said third layer for adhering said device to the skin or mucosa of a host.
10. The device of claim 1, wherein said first, second and third layers are planar layers overlying one another forming a laminate.
11. The device of claim 1, wherein said active agent impermeable layer is at least co-extensive with said third layer.
12. A method of making a device for the release of an active agent to the skin or mucosa or a host, said method comprising providing a first layer having adhesive properties adapted for adhering said first layer to the skin or mucosa of a host;
releaseably adhering a second layer to said first layer, said second layer having an opening exposing a portion of said first layer; overlying a third layer with said second layer, said third layer including an active agent impermeable layer;
and adhering a portion of said impermeable layer to said first layer within said opening in said second layer, said second layer separating a portion of said third layer from said first layer prior to removal of said second layer when adhering said device to the skin or mucosa of a host by said first layer.
releaseably adhering a second layer to said first layer, said second layer having an opening exposing a portion of said first layer; overlying a third layer with said second layer, said third layer including an active agent impermeable layer;
and adhering a portion of said impermeable layer to said first layer within said opening in said second layer, said second layer separating a portion of said third layer from said first layer prior to removal of said second layer when adhering said device to the skin or mucosa of a host by said first layer.
13. The method of claim 12, wherein at least one of said first layer and said third layer includes an active agent to be administered to the skin or mucosa of a host.
14. The method of claim 12, wherein said second layer comprises an active agent impermeable material.
15. The method of claim 12, wherein said third layer includes a circumferential portion surrounding said opening within said second layer, said circumferential portion separated from said first layer by said second layer interposed therebetween.
16. The method of claim 12, wherein said second layer includes at least one slot extending from an edge of said second layer to said opening.
17. The method of claim 12, wherein said first layer comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
18. The method of claim 12, further including a layer of active agent impermeable material releasably applied overlying said third layer.
19. The method of claim 12, wherein said third layer comprises pressure-sensitive adhesive material for adhering said device to the skin or mucosa of a host.
20. The method of claim 12, further including a layer of active agent permeable adhesive applied overlying said third layer for adhering said device to the skin or mucosa of a host.
21. The method of claim 12, wherein said first, second and third layers are planar layers overlying one another forming a laminate.
22. The method of claim 12, wherein said active agent impermeable layer is at least co-extensive with said third layer.
23. The method of claim 12, wherein said third layer is larger than said opening within said second layer and smaller than said first layer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/641,654 US8524272B2 (en) | 2003-08-15 | 2003-08-15 | Transdermal patch incorporating active agent migration barrier layer |
US10/641,654 | 2003-08-15 | ||
CA2531504A CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2531504A Division CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2637321A1 true CA2637321A1 (en) | 2005-03-03 |
CA2637321C CA2637321C (en) | 2010-04-13 |
Family
ID=34136410
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2637849A Expired - Fee Related CA2637849C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA002637297A Expired - Fee Related CA2637297C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2637321A Expired - Fee Related CA2637321C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2638743A Expired - Fee Related CA2638743C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2708347A Expired - Fee Related CA2708347C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2531504A Expired - Fee Related CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2637849A Expired - Fee Related CA2637849C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA002637297A Expired - Fee Related CA2637297C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2638743A Expired - Fee Related CA2638743C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2708347A Expired - Fee Related CA2708347C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
CA2531504A Expired - Fee Related CA2531504C (en) | 2003-08-15 | 2004-01-26 | Transdermal patch incorporating active agent migration barrier layer |
Country Status (7)
Country | Link |
---|---|
US (3) | US8524272B2 (en) |
EP (1) | EP1653897A4 (en) |
JP (1) | JP4388068B2 (en) |
AU (1) | AU2004266563B2 (en) |
CA (6) | CA2637849C (en) |
MX (1) | MXPA06001783A (en) |
WO (1) | WO2005018517A1 (en) |
Families Citing this family (25)
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ME00147B (en) * | 2003-02-21 | 2010-10-10 | Schering Ag | Uv stable transdermal therapeutic plaster |
US7867511B2 (en) | 2004-01-23 | 2011-01-11 | Travanti Pharma Inc. | Abuse potential reduction in abusable substance dosage form |
US8535711B2 (en) * | 2004-01-23 | 2013-09-17 | Teikoku Pharma Usa, Inc. | Medication disposal system |
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WO2006124584A2 (en) * | 2005-05-13 | 2006-11-23 | Alza Corporation | Multilayer drug delivery system with barrier against reservoir material flow |
WO2006124749A2 (en) * | 2005-05-13 | 2006-11-23 | Alza Corporation | Multilayer drug delivery system with barrier against antagonist exposure |
WO2007022535A2 (en) | 2005-08-19 | 2007-02-22 | Pharmacofore, Inc. | Prodrugs of active agents |
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JP5394083B2 (en) * | 2008-02-06 | 2014-01-22 | 日東電工株式会社 | Patch packaging structure |
DE102011080390B3 (en) * | 2011-08-03 | 2012-07-12 | Acino Ag | application aid |
CA2846956C (en) | 2011-09-30 | 2017-12-12 | Teikoku Pharma Usa, Inc. | Transdermal patch disposal system |
EP2760412B1 (en) | 2011-09-30 | 2017-07-19 | Verde Environmental Technologies, Inc. | General medication disposal system |
CN105287440A (en) * | 2014-06-18 | 2016-02-03 | 杨宁正 | Permeation type pharmaceutic thin film patch |
US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
GB2556817B (en) | 2015-10-01 | 2019-11-06 | Elysium Therapeutics Inc | Polysubunit opioid prodrugs resistant to overdose and abuse |
US10076473B2 (en) * | 2016-02-15 | 2018-09-18 | C&Tech Corporation | Apparatus and method for manufacturing dried gel sheet and gel sheet or beauty pack manufactured by the same |
AU2018234911B2 (en) | 2017-03-17 | 2024-04-18 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
US20190015352A1 (en) * | 2017-07-14 | 2019-01-17 | Pendleton Brewster Wickersham | Applicators & Patches for Dermal & Transdermal Treatment Material & Drug Delivery, Methods of Making Them, & Methods of Use |
US11389844B2 (en) | 2018-03-20 | 2022-07-19 | Verde Environmental Technologies, Inc. | Blister pack disposal system |
USD999385S1 (en) | 2021-10-18 | 2023-09-19 | Dbv Technologies | Patch assembly |
USD999384S1 (en) | 2021-10-18 | 2023-09-19 | Dbv Technologies | Patch assembly |
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-
2003
- 2003-08-15 US US10/641,654 patent/US8524272B2/en active Active
-
2004
- 2004-01-26 JP JP2006523817A patent/JP4388068B2/en not_active Expired - Fee Related
- 2004-01-26 CA CA2637849A patent/CA2637849C/en not_active Expired - Fee Related
- 2004-01-26 CA CA002637297A patent/CA2637297C/en not_active Expired - Fee Related
- 2004-01-26 EP EP04705280A patent/EP1653897A4/en not_active Withdrawn
- 2004-01-26 WO PCT/US2004/002105 patent/WO2005018517A1/en active Application Filing
- 2004-01-26 MX MXPA06001783A patent/MXPA06001783A/en active IP Right Grant
- 2004-01-26 CA CA2637321A patent/CA2637321C/en not_active Expired - Fee Related
- 2004-01-26 CA CA2638743A patent/CA2638743C/en not_active Expired - Fee Related
- 2004-01-26 CA CA2708347A patent/CA2708347C/en not_active Expired - Fee Related
- 2004-01-26 AU AU2004266563A patent/AU2004266563B2/en not_active Ceased
- 2004-01-26 CA CA2531504A patent/CA2531504C/en not_active Expired - Fee Related
-
2013
- 2013-06-13 US US13/916,712 patent/US8802136B2/en not_active Expired - Lifetime
-
2014
- 2014-05-15 US US14/278,486 patent/US9358373B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US8802136B2 (en) | 2014-08-12 |
US8524272B2 (en) | 2013-09-03 |
CA2708347C (en) | 2012-12-18 |
AU2004266563A1 (en) | 2005-03-03 |
CA2637321C (en) | 2010-04-13 |
CA2637849C (en) | 2010-04-13 |
MXPA06001783A (en) | 2006-05-04 |
AU2004266563B2 (en) | 2011-03-10 |
CA2531504A1 (en) | 2005-03-03 |
JP2007502649A (en) | 2007-02-15 |
US9358373B2 (en) | 2016-06-07 |
CA2637297A1 (en) | 2005-03-03 |
CA2638743C (en) | 2012-05-22 |
EP1653897A4 (en) | 2012-03-21 |
JP4388068B2 (en) | 2009-12-24 |
EP1653897A1 (en) | 2006-05-10 |
CA2708347A1 (en) | 2005-03-03 |
CA2638743A1 (en) | 2005-03-03 |
CA2531504C (en) | 2011-04-12 |
CA2637297C (en) | 2009-07-21 |
WO2005018517A1 (en) | 2005-03-03 |
US20130274694A1 (en) | 2013-10-17 |
US20140249492A1 (en) | 2014-09-04 |
US20050037059A1 (en) | 2005-02-17 |
CA2637849A1 (en) | 2005-03-03 |
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