CA2634301A1 - Biological surgical patch prepared from animal tissue - Google Patents

Biological surgical patch prepared from animal tissue Download PDF

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Publication number
CA2634301A1
CA2634301A1 CA002634301A CA2634301A CA2634301A1 CA 2634301 A1 CA2634301 A1 CA 2634301A1 CA 002634301 A CA002634301 A CA 002634301A CA 2634301 A CA2634301 A CA 2634301A CA 2634301 A1 CA2634301 A1 CA 2634301A1
Authority
CA
Canada
Prior art keywords
substrate
patch
animal tissue
antigens
epoxy compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002634301A
Other languages
French (fr)
Other versions
CA2634301C (en
Inventor
Guofeng Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUMMIT(GD) BIOTECH CO Ltd
Original Assignee
Summit(Gd) Biotech Co., Ltd
Guofeng Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Summit(Gd) Biotech Co., Ltd, Guofeng Xu filed Critical Summit(Gd) Biotech Co., Ltd
Publication of CA2634301A1 publication Critical patent/CA2634301A1/en
Application granted granted Critical
Publication of CA2634301C publication Critical patent/CA2634301C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment

Abstract

A biological surgical patch is made by a method that includes the steps of providing a natural animal tissue that has a substrate (1), crosslinking and fixing the substrate (1), minimizing the antigens from the substrate (1), tanning the substrate (1), an incorporating an active layer (2) in the substrate (1).

Claims (19)

1. A method for preparing a biological surgical patch, comprising:
providing a natural animal tissue that has a substrate;
crosslinking and fixing the substrate;
minimizing the antigens from the substrate;
tanning the substrate; and incorporating an active layer in the substrate.
2. The method of claim 1, wherein the active layer includes polypeptide or glycosaminoglycan.
3. The method of claim 1, wherein the cross-linking and fixing step is accomplished using an epoxy compound that has a hydrocarbon backbone, that is water-soluble, and which does not contain an ether or ester linkage in its backbone.
4. The method of claim 3, wherein the epoxy compound is selected from the group consisting of an epoxide, a diamide, a diisocyanate, or a carbodiimide.
5. The method of claim 1, wherein minimizing the antigens from the substrate include:
utilizing an active reagent to block specific active groups in the proteins of the substrate; and utilizing a reagent with strong hydrogen bonding power to replace the specific hydrogen bonding in the spiral chains of the protein molecules in the substrate and alter its specific conformation.
6. The method of claim 1, wherein the natural animal tissue is pericardium.
7. The method of claim 1, wherein tanning the substrate includes:
producing polymers from monomers; and grafting the polymers into collagen molecules.
8. A biological surgical patch, comprising:
a natural animal tissue that has a substrate that has been crosslinked, from which antigens have been minimized, and whose collagen molecules have been grafted, the substrate having an active layer incorporated therein.
9. The patch of claim 8, wherein the active layer includes a polypeptide or glycosaminoglycan.
10. The patch of claim 8, wherein the substrate is fixed by an epoxy compound that has a hydrocarbon backbone, that is water-soluble, and which does not contain an ether or ester linkage in its backbone.
11. The patch of claim 10, wherein the epoxy compound is selected from the group consisting of an epoxide, a diamide, a diisocyanate, or a carbodiimide.
12. The patch of claim 8, wherein the antigens are minimized from the substrate by an active reagent to block specific active groups in the proteins of the substrate, and a reagent with strong hydrogen bonding power to replace the specific hydrogen bonding in the spiral chains of the protein molecules in the substrate and alter its specific conformation.
13. The patch of claim 8, wherein the natural animal tissue is pericardium.
14 A biological surgical patch made by a method comprising:
providing a natural animal tissue that has a substrate;
crosslinking and fixing the substrate;
minimizing the antigens from the substrate;
tanning the substrate; and incorporating an active layer in the substrate.
15. The patch of claim 14, wherein the active layer includes a polypeptide or glycosaminoglycan.
16. The patch of claim 14, wherein the substrate is fixed by an epoxy compound that has a hydrocarbon backbone, that is water-soluble, and which does not contain an ether or ester linkage in its backbone.
17. The patch of claim 16, wherein the epoxy compound is selected from the group consisting of an epoxide, a diamide, a diisocyanate, or a carbodiimide.
18. The patch of claim 14, wherein the antigens are minimized from the substrate by an active reagent to block specific active groups in the proteins of the substrate, and a reagent with strong hydrogen bonding power to replace the specific hydrogen bonding in the spiral chains of the protein molecules in the substrate and alter its specific conformation.
19. The patch of claim 14, wherein the natural animal tissue is pericardium.
CA2634301A 2005-12-20 2006-12-15 Biological surgical patch prepared from animal tissue Active CA2634301C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200510120796.5 2005-12-20
CN2005101207965A CN1986007B (en) 2005-12-20 2005-12-20 Biological surgical patch
PCT/CN2006/003419 WO2007071164A1 (en) 2005-12-20 2006-12-15 Biological surgical patch and method of making

Publications (2)

Publication Number Publication Date
CA2634301A1 true CA2634301A1 (en) 2007-06-28
CA2634301C CA2634301C (en) 2012-02-14

Family

ID=38174705

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2634301A Active CA2634301C (en) 2005-12-20 2006-12-15 Biological surgical patch prepared from animal tissue

Country Status (8)

Country Link
US (1) US8100970B2 (en)
EP (1) EP1968659B1 (en)
JP (1) JP5415078B2 (en)
CN (1) CN1986007B (en)
AU (1) AU2006329149B2 (en)
CA (1) CA2634301C (en)
RU (1) RU2438714C2 (en)
WO (1) WO2007071164A1 (en)

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CN101332316B (en) * 2008-07-22 2012-12-26 广东冠昊生物科技股份有限公司 Biotype nose bridge implantation body
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CN101773419B (en) * 2009-01-13 2013-08-21 樊昊 Pelvic floor repairing patch
CN101480360B (en) * 2009-01-22 2012-08-29 广东冠昊生物科技股份有限公司 Mammary prostheses supporting device
CN102753105B (en) * 2010-02-19 2015-09-30 生命细胞公司 Stomach wall therapy equipment
CN104436305B (en) * 2014-11-05 2017-01-11 暨南大学 Cardiac muscle tonifying tablet taking acellular biological membrane as carrier as well as preparation method and application of cardiac muscle tonifying tablet
CN105935454A (en) * 2015-09-18 2016-09-14 广州市美昊生物科技有限公司 Decellularized matrix-source tissue engineering scaffold and preparation method and application thereof
CN105903080B (en) * 2016-05-23 2019-04-02 苏州恒瑞迪生医疗科技有限公司 A kind of breast sticking patch and preparation method thereof
RU183498U1 (en) * 2018-03-01 2018-09-24 федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения РФ Artery wall defect closure
CN116440328A (en) * 2022-01-14 2023-07-18 爱美客技术发展股份有限公司 Regulation method of degradation period of acellular biological tissue material and application thereof
CN116440312A (en) * 2022-01-14 2023-07-18 爱美客技术发展股份有限公司 Medical material containing decellularized biological tissue material

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Also Published As

Publication number Publication date
EP1968659B1 (en) 2016-11-16
JP2009519789A (en) 2009-05-21
JP5415078B2 (en) 2014-02-12
CN1986007A (en) 2007-06-27
CA2634301C (en) 2012-02-14
US8100970B2 (en) 2012-01-24
AU2006329149A1 (en) 2007-06-28
US20070142847A1 (en) 2007-06-21
RU2438714C2 (en) 2012-01-10
EP1968659A4 (en) 2012-07-04
RU2008127983A (en) 2010-01-27
AU2006329149B2 (en) 2013-03-14
EP1968659A1 (en) 2008-09-17
WO2007071164A1 (en) 2007-06-28
CN1986007B (en) 2011-09-14

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