CA2617668A1 - A hemangioma clip having a biological membrame - Google Patents

A hemangioma clip having a biological membrame Download PDF

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Publication number
CA2617668A1
CA2617668A1 CA002617668A CA2617668A CA2617668A1 CA 2617668 A1 CA2617668 A1 CA 2617668A1 CA 002617668 A CA002617668 A CA 002617668A CA 2617668 A CA2617668 A CA 2617668A CA 2617668 A1 CA2617668 A1 CA 2617668A1
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CA
Canada
Prior art keywords
biological membrane
clip
preparation
hemangioma
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002617668A
Other languages
French (fr)
Other versions
CA2617668C (en
Inventor
Songtao Qi
Guofeng Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUMMIT (GD) BIOTECH CO Ltd
Original Assignee
Summit (Gd) Biotech Co., Ltd
Songtao Qi
Guofeng Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Summit (Gd) Biotech Co., Ltd, Songtao Qi, Guofeng Xu filed Critical Summit (Gd) Biotech Co., Ltd
Publication of CA2617668A1 publication Critical patent/CA2617668A1/en
Application granted granted Critical
Publication of CA2617668C publication Critical patent/CA2617668C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/122—Clamps or clips, e.g. for the umbilical cord
    • A61B17/1227—Spring clips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00884—Material properties enhancing wound closure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00893—Material properties pharmaceutically effective

Abstract

A hemangioma clip with a biological membrane is composed of a metal clip and a biological membrane (3), wherein the metal clip is made of medical stainless steel or titanium alloy, and its structure includes a first clamping rod (5) and a second clamping rod (6) overlapping one another. The rear parts of the rods are connected via a resilient member (7). There are provided a first clamping arm (1) and a second clamping arm (2) at the respective ends of the half collars (8) (9) of the first clamping rod (5) and the second clamping rod (6). Two ends of the biological membrane (3) are fastened on the first clamping arm (1) and the second clamping arm (2) respectively, forming a membrane cover.

Claims (11)

1. A hemangioma clip having a biological membrane, comprising a metal clip and a biological membrane (3), wherein the metal clip is made of medical stainless steel or titantium alloy, the metal clip comprises a first clamping rod (5) and a second clamping rod (6), whose rear parts are connected through a resilient member (7) and cross and overlap; the half collar (8) comprises the first clamping rod (5), and the half collar (9) comprises the second clamping rod (6), at whose two ends disposed are a first clamping arm (1) and a second clamping arm (2), respectively; and the two ends of the biological membrane (3) are stabilized on said first clamping arm (1) and said second clamping arm (2), respectively, to form a membrane cover.
2. A method of preparation of the hemangioma clip having a biological membrane of claim 1, wherein said biological membrane is formed from a diaphragm, fatty omentum, pericardium and intestinal membranes of pigs, cows or sheep, by crosslinking and fixing with an epoxide, and treating to remove antigens.
3. The method of preparation of the hemangioma clip having a biological membrane of claim1, wherein said biological membrane (3) couples with the active coating (4) containing active components such as certain specific polypeptides or glucosaminoglycans so as to bind growth factors.
4. The method of preparation of the hemangioma clip having a biological membrane of claim1, wherein one of said polypeptides is made of 16 lysines (K16), glycine (G), arginine (R), aspartic acid (D), serine (S), proline (P), and cysteine (C), through condensation, and said glucosaminoglycan may be hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparin, heparitin sulfate, or keratan sulfate.
5. The method of preparation of the hemangioma clip having a biological membrane of any of claims 1, 2, 3 or 4, wherein, the length of said biological membrane (3) is the same as the circumference of the collar (10) formed by a fist half collar (8) and a second half collar (9).
6. The method of preparation of the hemangioma clip having a biological membrane of claim 2, wherein said biological membrane (3) is prepared from hard-membrane natural animal tissues taken as the raw material, according to the following steps:

1) Pretreatment: Initial sterilization is performed using a broad spectrum, highly-effective, low-toxicity bactericide, followed by trimming irregular portions;
2) Fixation: The protein molecules in the biological membrane (3) are crosslinked and fixed with a fixative;

3) Antigen elimination: The specific active groups of proteins in the biological membrane (3), such as -OH, -NH2, -SH, and so on, are blocked with active reagents, and the specific conformation of them is changed, by substituting reagents forming strong hydrogen bonds for the special hydrogen bonds in helix chains of protein molecules in the substrate; finally, the two ends of the obtained biological membrane (3) are stabilized on the clamping arms of the metal clip with a medical adhesive, respectively.
7. The method of preparation of the hemangioma clip having a biological membrane of claim 5 comprising further an additional step, wherein by means of a coupling agent, the surface of the biological membrane (3) couples with the active coating (4) which contains active components of certain specific polypeptides or glucosaminoglycans so as to bind growth actors.
8. The method of preparation of the hemangioma clip having a biological membrane of claim 6, wherein, one of said polypeptides is made of 16 lysines (K16), a glycine (G), an arginine (R), an aspartic acid (D), a serine (S), a proline (P), and a cysteine (C) through condensation, and the glucosaminoglycan may be hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparin, heparitin sulfate, or keratan sulfate.
9. The method of preparation of the hemangioma clip having a biological membrane of claims 5 or 6, wherein said fixative may be one or two of the reagents readily undergoing a crosslinking reaction with a protein molecule, such as an epoxide, a diamide, a diisocyanate, or a carbodiimide; and said epoxide may be a monoepoxide of the following formula or a diepoxide of the following formula R=C n H2n+1, and n=0-10.
10. The method of preparation of the hemangioma clip having a biological membrane of claims 5 or 6, wherein said active reagent is an organic acid, an anhydride with a low molecular weight, an acetyl chloride, an acrylamide, or a monocyclic oxide, and said reagent forming strong hydrogen bonds is a guanidine compound.
11. The method of preparation of the hemangioma clip having a biological membrane of claim 6, wherein the coupling agent is an acetyl diamide, a dianhydride, a diepoxide, or any other compound with double functional groups, which participates in a condensation reaction with groups, such as -NH2, -OH, or -COOH.
CA2617668A 2005-08-04 2006-07-27 A hemangioma clip having a biological membrame Active CA2617668C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNB2005100363152A CN100482178C (en) 2005-08-04 2005-08-04 Blood vessel tumor clip with biological film
CN200510036315.2 2005-08-04
PCT/CN2006/001878 WO2007014518A1 (en) 2005-08-04 2006-07-27 A hemangioma clip with a biological membrane

Publications (2)

Publication Number Publication Date
CA2617668A1 true CA2617668A1 (en) 2007-02-08
CA2617668C CA2617668C (en) 2011-11-08

Family

ID=37698581

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2617668A Active CA2617668C (en) 2005-08-04 2006-07-27 A hemangioma clip having a biological membrame

Country Status (10)

Country Link
US (1) US8197500B2 (en)
EP (1) EP1911406B1 (en)
JP (1) JP4891996B2 (en)
CN (1) CN100482178C (en)
AT (1) ATE466529T1 (en)
AU (1) AU2006275235C1 (en)
CA (1) CA2617668C (en)
DE (1) DE602006014161D1 (en)
RU (1) RU2423938C2 (en)
WO (1) WO2007014518A1 (en)

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DE102020100718A1 (en) * 2020-01-14 2021-07-15 Aesculap Ag Surgical clip, in particular aneurysm clip, with a passive coating

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Also Published As

Publication number Publication date
CN100482178C (en) 2009-04-29
EP1911406A4 (en) 2008-12-03
AU2006275235A1 (en) 2007-02-08
RU2008107011A (en) 2009-09-10
ATE466529T1 (en) 2010-05-15
WO2007014518A1 (en) 2007-02-08
EP1911406A1 (en) 2008-04-16
US20070032806A1 (en) 2007-02-08
RU2423938C2 (en) 2011-07-20
US8197500B2 (en) 2012-06-12
CA2617668C (en) 2011-11-08
JP2009502371A (en) 2009-01-29
EP1911406B1 (en) 2010-05-05
CN1907234A (en) 2007-02-07
AU2006275235B2 (en) 2012-07-12
AU2006275235C1 (en) 2013-01-24
DE602006014161D1 (en) 2010-06-17
JP4891996B2 (en) 2012-03-07

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