CA2610945C - Foamable alcohol compositions, systems and methods of use - Google Patents
Foamable alcohol compositions, systems and methods of use Download PDFInfo
- Publication number
- CA2610945C CA2610945C CA2610945A CA2610945A CA2610945C CA 2610945 C CA2610945 C CA 2610945C CA 2610945 A CA2610945 A CA 2610945A CA 2610945 A CA2610945 A CA 2610945A CA 2610945 C CA2610945 C CA 2610945C
- Authority
- CA
- Canada
- Prior art keywords
- composition
- dimethicone
- foam
- copolyol
- polyquaternium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 225
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 80
- 238000000034 method Methods 0.000 title abstract description 10
- 239000006260 foam Substances 0.000 claims abstract description 167
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract description 147
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 147
- 229940008099 dimethicone Drugs 0.000 claims abstract description 146
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 146
- 239000004094 surface-active agent Substances 0.000 claims abstract description 59
- -1 hydroxypropyl Chemical group 0.000 claims description 88
- 239000003974 emollient agent Substances 0.000 claims description 38
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 30
- 229920001223 polyethylene glycol Polymers 0.000 claims description 29
- 229920001296 polysiloxane Polymers 0.000 claims description 26
- 239000002202 Polyethylene glycol Substances 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 239000000443 aerosol Substances 0.000 claims description 20
- 239000004599 antimicrobial Substances 0.000 claims description 20
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 16
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 16
- 239000011734 sodium Substances 0.000 claims description 16
- 229910052708 sodium Inorganic materials 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 14
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 14
- 239000003380 propellant Substances 0.000 claims description 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 12
- 229920002554 vinyl polymer Polymers 0.000 claims description 12
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 11
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 8
- 238000005187 foaming Methods 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 229960005150 glycerol Drugs 0.000 claims description 8
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 8
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 7
- 150000002170 ethers Chemical class 0.000 claims description 7
- 229920001519 homopolymer Polymers 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 6
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 6
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 6
- 239000004166 Lanolin Substances 0.000 claims description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 6
- 235000019388 lanolin Nutrition 0.000 claims description 6
- 229940039717 lanolin Drugs 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 claims description 5
- 229920000896 Ethulose Polymers 0.000 claims description 5
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 5
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 5
- 230000004888 barrier function Effects 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 5
- 229960003237 betaine Drugs 0.000 claims description 5
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims description 5
- 150000002334 glycols Chemical class 0.000 claims description 5
- 229940070765 laurate Drugs 0.000 claims description 5
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- 229920002401 polyacrylamide Polymers 0.000 claims description 5
- 239000004584 polyacrylic acid Substances 0.000 claims description 5
- 229920000223 polyglycerol Polymers 0.000 claims description 5
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- 229960003500 triclosan Drugs 0.000 claims description 5
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 claims description 4
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims description 4
- 235000007173 Abies balsamea Nutrition 0.000 claims description 4
- 239000004857 Balsam Substances 0.000 claims description 4
- 244000018716 Impatiens biflora Species 0.000 claims description 4
- 229920000688 Poly[(2-ethyldimethylammonioethyl methacrylate ethyl sulfate)-co-(1-vinylpyrrolidone)] Polymers 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 4
- FBUKVWPVBMHYJY-UHFFFAOYSA-M nonanoate Chemical compound CCCCCCCCC([O-])=O FBUKVWPVBMHYJY-UHFFFAOYSA-M 0.000 claims description 4
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims description 4
- 239000011787 zinc oxide Substances 0.000 claims description 4
- 235000014692 zinc oxide Nutrition 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 3
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 3
- 108010009736 Protein Hydrolysates Proteins 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- AMZWNNKNOQSBOP-UHFFFAOYSA-M [n'-(2,5-dioxoimidazolidin-4-yl)carbamimidoyl]oxyaluminum;dihydrate Chemical compound O.O.NC(=O)NC1N=C(O[Al])NC1=O AMZWNNKNOQSBOP-UHFFFAOYSA-M 0.000 claims description 3
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 3
- HDYRYUINDGQKMC-UHFFFAOYSA-M acetyloxyaluminum;dihydrate Chemical compound O.O.CC(=O)O[Al] HDYRYUINDGQKMC-UHFFFAOYSA-M 0.000 claims description 3
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims description 3
- 229940015825 aldioxa Drugs 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- 229940009827 aluminum acetate Drugs 0.000 claims description 3
- 229940024545 aluminum hydroxide Drugs 0.000 claims description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 3
- 239000004327 boric acid Substances 0.000 claims description 3
- 229960002645 boric acid Drugs 0.000 claims description 3
- 235000010338 boric acid Nutrition 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 235000010980 cellulose Nutrition 0.000 claims description 3
- 229960003260 chlorhexidine Drugs 0.000 claims description 3
- 229940080421 coco glucoside Drugs 0.000 claims description 3
- 229920006037 cross link polymer Polymers 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 229940097413 isopropyl maleate Drugs 0.000 claims description 3
- 239000002480 mineral oil Substances 0.000 claims description 3
- 235000010446 mineral oil Nutrition 0.000 claims description 3
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 claims description 3
- 229920001798 poly[2-(acrylamido)-2-methyl-1-propanesulfonic acid] polymer Polymers 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 229940075466 undecylenate Drugs 0.000 claims description 3
- 239000004246 zinc acetate Substances 0.000 claims description 3
- 235000013904 zinc acetate Nutrition 0.000 claims description 3
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 claims description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 2
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 claims description 2
- GAVHQOUUSHBDAA-UHFFFAOYSA-N 3-butyl-1-ethenylaziridin-2-one Chemical compound CCCCC1N(C=C)C1=O GAVHQOUUSHBDAA-UHFFFAOYSA-N 0.000 claims description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical group C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 2
- HWSISDHAHRVNMT-UHFFFAOYSA-N Bismuth subnitrate Chemical compound O[NH+]([O-])O[Bi](O[N+]([O-])=O)O[N+]([O-])=O HWSISDHAHRVNMT-UHFFFAOYSA-N 0.000 claims description 2
- 235000004866 D-panthenol Nutrition 0.000 claims description 2
- 239000011703 D-panthenol Substances 0.000 claims description 2
- 239000001263 FEMA 3042 Substances 0.000 claims description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims description 2
- 229920000691 Poly[bis(2-chloroethyl) ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] Polymers 0.000 claims description 2
- 229920002413 Polyhexanide Polymers 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 229940121375 antifungal agent Drugs 0.000 claims description 2
- 239000003429 antifungal agent Substances 0.000 claims description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 2
- 229960001482 bismuth subnitrate Drugs 0.000 claims description 2
- 229940105847 calamine Drugs 0.000 claims description 2
- 235000019868 cocoa butter Nutrition 0.000 claims description 2
- 229940110456 cocoa butter Drugs 0.000 claims description 2
- 239000003026 cod liver oil Substances 0.000 claims description 2
- 235000012716 cod liver oil Nutrition 0.000 claims description 2
- 229940052366 colloidal oatmeal Drugs 0.000 claims description 2
- 229960001305 cysteine hydrochloride Drugs 0.000 claims description 2
- 229960003949 dexpanthenol Drugs 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 229910052864 hemimorphite Inorganic materials 0.000 claims description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- 229940035535 iodophors Drugs 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 108010083821 live yeast cell derivative Proteins 0.000 claims description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims description 2
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims description 2
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims description 2
- 150000002978 peroxides Chemical class 0.000 claims description 2
- 235000019271 petrolatum Nutrition 0.000 claims description 2
- 239000003531 protein hydrolysate Substances 0.000 claims description 2
- 229940080308 racemethionine Drugs 0.000 claims description 2
- 229940069764 shark liver oil Drugs 0.000 claims description 2
- 239000010686 shark liver oil Substances 0.000 claims description 2
- 229910052709 silver Inorganic materials 0.000 claims description 2
- 239000004332 silver Substances 0.000 claims description 2
- 229910001923 silver oxide Inorganic materials 0.000 claims description 2
- 230000008591 skin barrier function Effects 0.000 claims description 2
- 235000001508 sulfur Nutrition 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 229960005349 sulfur Drugs 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 229940033134 talc Drugs 0.000 claims description 2
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims description 2
- 229940033123 tannic acid Drugs 0.000 claims description 2
- 235000015523 tannic acid Nutrition 0.000 claims description 2
- 229920002258 tannic acid Polymers 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 235000019155 vitamin A Nutrition 0.000 claims description 2
- 239000011719 vitamin A Substances 0.000 claims description 2
- 235000005282 vitamin D3 Nutrition 0.000 claims description 2
- 239000011647 vitamin D3 Substances 0.000 claims description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 2
- 229940045997 vitamin a Drugs 0.000 claims description 2
- 229940021056 vitamin d3 Drugs 0.000 claims description 2
- 239000003871 white petrolatum Substances 0.000 claims description 2
- 239000011667 zinc carbonate Substances 0.000 claims description 2
- 235000004416 zinc carbonate Nutrition 0.000 claims description 2
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 2
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 claims description 2
- NKYXPUKJMFIOLB-UHFFFAOYSA-N 1-ethenyl-3-propylaziridin-2-one Chemical compound CCCC1N(C=C)C1=O NKYXPUKJMFIOLB-UHFFFAOYSA-N 0.000 claims 1
- 229920005606 polypropylene copolymer Polymers 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 32
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 20
- 210000003491 skin Anatomy 0.000 description 20
- 229920001451 polypropylene glycol Polymers 0.000 description 18
- 239000000126 substance Substances 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 13
- 238000009472 formulation Methods 0.000 description 13
- 229920000642 polymer Polymers 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 8
- 229940022663 acetate Drugs 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 150000001298 alcohols Chemical class 0.000 description 6
- 229920001983 poloxamer Polymers 0.000 description 6
- 102220045258 rs587781957 Human genes 0.000 description 6
- ATIAIEWDRRJGSL-UHFFFAOYSA-N 1,3-bis(2-hydroxyethyl)-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(CCO)C(=O)N(CCO)C1=O ATIAIEWDRRJGSL-UHFFFAOYSA-N 0.000 description 5
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000003906 humectant Substances 0.000 description 5
- 229940001447 lactate Drugs 0.000 description 5
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 description 4
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical compound C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000004479 aerosol dispenser Substances 0.000 description 4
- 150000001335 aliphatic alkanes Chemical class 0.000 description 4
- 150000007860 aryl ester derivatives Chemical class 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 238000001704 evaporation Methods 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229940043348 myristyl alcohol Drugs 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 3
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 description 3
- KUXUALPOSMRJSW-IFWQJVLJSA-N 2-[6-[[amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 KUXUALPOSMRJSW-IFWQJVLJSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 229940050390 benzoate Drugs 0.000 description 3
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 3
- 229920001400 block copolymer Polymers 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000002009 diols Chemical class 0.000 description 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229960001915 hexamidine Drugs 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 239000011630 iodine Substances 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000003607 modifier Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 238000011012 sanitization Methods 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 2
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 2
- FZIPCQLKPTZZIM-UHFFFAOYSA-N 2-oxidanylpropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O FZIPCQLKPTZZIM-UHFFFAOYSA-N 0.000 description 2
- WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- 229920003091 Methocel™ Polymers 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- YSJGOMATDFSEED-UHFFFAOYSA-M behentrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C YSJGOMATDFSEED-UHFFFAOYSA-M 0.000 description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 2
- BHKPHCKISVSDGV-UHFFFAOYSA-N benzoic acid 8-quinolinyl ester Chemical compound C=1C=CC2=CC=CN=C2C=1OC(=O)C1=CC=CC=C1 BHKPHCKISVSDGV-UHFFFAOYSA-N 0.000 description 2
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 2
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 2
- XSIFPSYPOVKYCO-UHFFFAOYSA-N butyl benzoate Chemical compound CCCCOC(=O)C1=CC=CC=C1 XSIFPSYPOVKYCO-UHFFFAOYSA-N 0.000 description 2
- 229940081733 cetearyl alcohol Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- AIPVRBGBHQDAPX-UHFFFAOYSA-N hydroxy(methyl)silane Chemical compound C[SiH2]O AIPVRBGBHQDAPX-UHFFFAOYSA-N 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
- 229960000367 inositol Drugs 0.000 description 2
- 239000001282 iso-butane Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 150000004704 methoxides Chemical class 0.000 description 2
- PTOJVMZPWPAXER-VFJVYMGBSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(e,3r)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate Chemical compound O[C@@H]1CC(=O)[C@H](CC=C=CCCC(=O)OC)[C@H]1\C=C\[C@@H](O)COC1=CC=CC=C1 PTOJVMZPWPAXER-VFJVYMGBSA-N 0.000 description 2
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 2
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- XTUSEBKMEQERQV-UHFFFAOYSA-N propan-2-ol;hydrate Chemical compound O.CC(C)O XTUSEBKMEQERQV-UHFFFAOYSA-N 0.000 description 2
- 239000001294 propane Substances 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- WEYVVCKOOFYHRW-UHFFFAOYSA-N usnic acid Chemical compound CC12C(=O)C(C(=O)C)=C(O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O WEYVVCKOOFYHRW-UHFFFAOYSA-N 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- OQWIKYXFAZAALW-FMDYKLJDSA-N (2S)-2-amino-5-oxo-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoic acid Chemical compound N[C@@H](CCC(=O)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(O)=O OQWIKYXFAZAALW-FMDYKLJDSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- WQKLGQXWHKQTPO-UXRZSMILSA-N (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol;2-(2-hydroxypropoxy)propan-1-ol Chemical compound CC(O)COC(C)CO.CC(O)COC(C)CO.CC(O)COC(C)CO.CC(O)COC(C)CO.CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O WQKLGQXWHKQTPO-UXRZSMILSA-N 0.000 description 1
- OBENDWOJIFFDLZ-UHFFFAOYSA-N (3,5-dimethylpyrazol-1-yl)methanol Chemical compound CC=1C=C(C)N(CO)N=1 OBENDWOJIFFDLZ-UHFFFAOYSA-N 0.000 description 1
- YGKOYVNJPRSSRX-UHFFFAOYSA-M (4-dodecylphenyl)methyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC1=CC=C(C[N+](C)(C)C)C=C1 YGKOYVNJPRSSRX-UHFFFAOYSA-M 0.000 description 1
- MGAXYKDBRBNWKT-UHFFFAOYSA-N (5-oxooxolan-2-yl)methyl 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OCC1OC(=O)CC1 MGAXYKDBRBNWKT-UHFFFAOYSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 1
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 description 1
- AVZICXRYXLCFCK-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate;2-dodecylisoquinolin-2-ium Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1.C1=CC=CC2=C[N+](CCCCCCCCCCCC)=CC=C21 AVZICXRYXLCFCK-UHFFFAOYSA-M 0.000 description 1
- JCIIKRHCWVHVFF-UHFFFAOYSA-N 1,2,4-thiadiazol-5-amine;hydrochloride Chemical compound Cl.NC1=NC=NS1 JCIIKRHCWVHVFF-UHFFFAOYSA-N 0.000 description 1
- ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 description 1
- IFWQSSUUCVSCSK-UHFFFAOYSA-N 1,2-hexacosanediol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCC(O)CO IFWQSSUUCVSCSK-UHFFFAOYSA-N 0.000 description 1
- ZPFAVCIQZKRBGF-UHFFFAOYSA-N 1,3,2-dioxathiolane 2,2-dioxide Chemical compound O=S1(=O)OCCO1 ZPFAVCIQZKRBGF-UHFFFAOYSA-N 0.000 description 1
- BFHKYHMIVDBCPC-UHFFFAOYSA-N 1,3,5,7-tetrahydro-[1,3]oxazolo[3,4-c][1,3]oxazol-7a-ylmethanol Chemical compound C1OCN2COCC21CO BFHKYHMIVDBCPC-UHFFFAOYSA-N 0.000 description 1
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 description 1
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 description 1
- XOILGBPDXMVFIP-UHFFFAOYSA-N 1-(diiodomethylsulfonyl)-4-methylbenzene Chemical compound CC1=CC=C(S(=O)(=O)C(I)I)C=C1 XOILGBPDXMVFIP-UHFFFAOYSA-N 0.000 description 1
- SIQZJFKTROUNPI-UHFFFAOYSA-N 1-(hydroxymethyl)-5,5-dimethylhydantoin Chemical compound CC1(C)N(CO)C(=O)NC1=O SIQZJFKTROUNPI-UHFFFAOYSA-N 0.000 description 1
- IWYNVAJACBPVLT-UHFFFAOYSA-N 1-[10-(4-amino-2-methylquinolin-1-ium-1-yl)decyl]-2-methylquinolin-1-ium-4-amine;diacetate Chemical compound CC([O-])=O.CC([O-])=O.C1=CC=C2[N+](CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C)=C(C)C=C(N)C2=C1 IWYNVAJACBPVLT-UHFFFAOYSA-N 0.000 description 1
- AOSFMYBATFLTAQ-UHFFFAOYSA-N 1-amino-3-(benzimidazol-1-yl)propan-2-ol Chemical compound C1=CC=C2N(CC(O)CN)C=NC2=C1 AOSFMYBATFLTAQ-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- IDQBJILTOGBZCR-UHFFFAOYSA-N 1-butoxypropan-1-ol Chemical compound CCCCOC(O)CC IDQBJILTOGBZCR-UHFFFAOYSA-N 0.000 description 1
- GKQHIYSTBXDYNQ-UHFFFAOYSA-M 1-dodecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+]1=CC=CC=C1 GKQHIYSTBXDYNQ-UHFFFAOYSA-M 0.000 description 1
- IBLKWZIFZMJLFL-UHFFFAOYSA-N 1-phenoxypropan-2-ol Chemical compound CC(O)COC1=CC=CC=C1 IBLKWZIFZMJLFL-UHFFFAOYSA-N 0.000 description 1
- VRACDWUCKIDHCO-UHFFFAOYSA-N 16-methylheptadecyl 10-[5,6-dihexyl-2-[8-(16-methylheptadecoxy)-8-oxooctyl]cyclohex-3-en-1-yl]dec-9-enoate Chemical class CCCCCCC1C=CC(CCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C)C(C=CCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C)C1CCCCCC VRACDWUCKIDHCO-UHFFFAOYSA-N 0.000 description 1
- VSHIRTNKIXRXMI-UHFFFAOYSA-N 2,2-dimethyl-1,3-oxazolidine Chemical compound CC1(C)NCCO1 VSHIRTNKIXRXMI-UHFFFAOYSA-N 0.000 description 1
- HSQFVBWFPBKHEB-UHFFFAOYSA-N 2,3,4-trichlorophenol Chemical compound OC1=CC=C(Cl)C(Cl)=C1Cl HSQFVBWFPBKHEB-UHFFFAOYSA-N 0.000 description 1
- QFZKSWMAYXNSEJ-UHFFFAOYSA-N 2,3-bis(2-hydroxypropanoyloxy)propyl 2-hydroxypropanoate Chemical compound CC(O)C(=O)OCC(OC(=O)C(C)O)COC(=O)C(C)O QFZKSWMAYXNSEJ-UHFFFAOYSA-N 0.000 description 1
- PVFDHBVUOPZPAK-UHFFFAOYSA-N 2,3-dihydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO.CCCCCCCCCCCC(=O)OCC(O)CO PVFDHBVUOPZPAK-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- IYOLBFFHPZOQGW-UHFFFAOYSA-N 2,4-dichloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=C(Cl)C(C)=C1Cl IYOLBFFHPZOQGW-UHFFFAOYSA-N 0.000 description 1
- ZILVNHNSYBNLSZ-UHFFFAOYSA-N 2-(diaminomethylideneamino)guanidine Chemical compound NC(N)=NNC(N)=N ZILVNHNSYBNLSZ-UHFFFAOYSA-N 0.000 description 1
- XZXYQEHISUMZAT-UHFFFAOYSA-N 2-[(2-hydroxy-5-methylphenyl)methyl]-4-methylphenol Chemical compound CC1=CC=C(O)C(CC=2C(=CC=C(C)C=2)O)=C1 XZXYQEHISUMZAT-UHFFFAOYSA-N 0.000 description 1
- HPKFFZSXDWPVLX-UHFFFAOYSA-N 2-[(2-pyridin-1-ium-1-ylacetyl)amino]ethyl dodecanoate;chloride Chemical compound [Cl-].CCCCCCCCCCCC(=O)OCCNC(=O)C[N+]1=CC=CC=C1 HPKFFZSXDWPVLX-UHFFFAOYSA-N 0.000 description 1
- LNEXUGPWTFNCSO-UHFFFAOYSA-N 2-[(2-pyridin-1-ium-1-ylacetyl)amino]ethyl octadecanoate;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC(=O)OCCNC(=O)C[N+]1=CC=CC=C1 LNEXUGPWTFNCSO-UHFFFAOYSA-N 0.000 description 1
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 1
- GIOMCCKTXLHGSZ-UHFFFAOYSA-N 2-[3-(2-dodecanoyloxyethyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCN1C(=O)N(CCOC(=O)CCCCCCCCCCC)C(C)(C)C1=O GIOMCCKTXLHGSZ-UHFFFAOYSA-N 0.000 description 1
- UITSPQLTFPTHJZ-UHFFFAOYSA-N 2-[[3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical compound COC1OC(COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-UHFFFAOYSA-N 0.000 description 1
- GPOFRJKTYRFQLJ-UHFFFAOYSA-N 2-aminoethanol;undec-10-enoic acid Chemical compound NCCO.OC(=O)CCCCCCCCC=C GPOFRJKTYRFQLJ-UHFFFAOYSA-N 0.000 description 1
- KWIPUXXIFQQMKN-UHFFFAOYSA-N 2-azaniumyl-3-(4-cyanophenyl)propanoate Chemical compound OC(=O)C(N)CC1=CC=C(C#N)C=C1 KWIPUXXIFQQMKN-UHFFFAOYSA-N 0.000 description 1
- NCKMMSIFQUPKCK-UHFFFAOYSA-N 2-benzyl-4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1CC1=CC=CC=C1 NCKMMSIFQUPKCK-UHFFFAOYSA-N 0.000 description 1
- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 description 1
- BSSVGSNJRDOYQS-UHFFFAOYSA-N 2-bromo-2-nitropropanedial Chemical compound [O-][N+](=O)C(Br)(C=O)C=O BSSVGSNJRDOYQS-UHFFFAOYSA-N 0.000 description 1
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
- WGPVWXXJNUNBNB-UHFFFAOYSA-N 2-carboxyphenolate;2-hydroxyethylazanium Chemical compound NCCO.OC(=O)C1=CC=CC=C1O WGPVWXXJNUNBNB-UHFFFAOYSA-N 0.000 description 1
- MSJLMQTXVKCUCD-UHFFFAOYSA-M 2-dodecylisoquinolin-2-ium;bromide Chemical compound [Br-].C1=CC=CC2=C[N+](CCCCCCCCCCCC)=CC=C21 MSJLMQTXVKCUCD-UHFFFAOYSA-M 0.000 description 1
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 1
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical class CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
- DUAYDERMVQWIJD-UHFFFAOYSA-N 2-n,2-n,6-trimethyl-1,3,5-triazine-2,4-diamine Chemical compound CN(C)C1=NC(C)=NC(N)=N1 DUAYDERMVQWIJD-UHFFFAOYSA-N 0.000 description 1
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- GGPOVLCFVFOVDF-UHFFFAOYSA-N 2-phenoxyethyl 4-hydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OCCOC1=CC=CC=C1 GGPOVLCFVFOVDF-UHFFFAOYSA-N 0.000 description 1
- AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 description 1
- OJOKXBOONCXWCY-XCECJLTFSA-N 3-[[(z,12r)-12-hydroxyoctadec-9-enoyl]amino]propyl-trimethylazanium;methyl sulfate Chemical compound COS([O-])(=O)=O.CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)NCCC[N+](C)(C)C OJOKXBOONCXWCY-XCECJLTFSA-N 0.000 description 1
- XYRDGCCCBJITBH-UHFFFAOYSA-N 3-amino-2-chloro-6-methylphenol Chemical compound CC1=CC=C(N)C(Cl)=C1O XYRDGCCCBJITBH-UHFFFAOYSA-N 0.000 description 1
- VFDASNWZZRLEAU-UHFFFAOYSA-N 3-bromo-4-[3-(2-bromo-4-carbamimidoylphenoxy)propoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid Chemical compound OCCS(O)(=O)=O.OCCS(O)(=O)=O.BrC1=CC(C(=N)N)=CC=C1OCCCOC1=CC=C(C(N)=N)C=C1Br VFDASNWZZRLEAU-UHFFFAOYSA-N 0.000 description 1
- WVUOPBSOWQHUDD-UHFFFAOYSA-M 3-heptyl-n,n,2-trimethyl-4-(2-phenylethenyl)-1,3-thiazol-3-ium-5-amine;iodide Chemical compound [I-].CCCCCCC[N+]1=C(C)SC(N(C)C)=C1C=CC1=CC=CC=C1 WVUOPBSOWQHUDD-UHFFFAOYSA-M 0.000 description 1
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- TZZGHGKTHXIOMN-UHFFFAOYSA-N 3-trimethoxysilyl-n-(3-trimethoxysilylpropyl)propan-1-amine Chemical compound CO[Si](OC)(OC)CCCNCCC[Si](OC)(OC)OC TZZGHGKTHXIOMN-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- KFZXVMNBUMVKLN-UHFFFAOYSA-N 4-chloro-5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC(Cl)=C(C)C=C1O KFZXVMNBUMVKLN-UHFFFAOYSA-N 0.000 description 1
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- 229940046305 5-bromo-5-nitro-1,3-dioxane Drugs 0.000 description 1
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- ZRCMGIXRGFOXNT-UHFFFAOYSA-N 7a-ethyl-1,3,5,7-tetrahydro-[1,3]oxazolo[3,4-c][1,3]oxazole Chemical compound C1OCN2COCC21CC ZRCMGIXRGFOXNT-UHFFFAOYSA-N 0.000 description 1
- ZYQIUVQBZWVFRE-UHFFFAOYSA-N 8-methylnonyl 4-hydroxybenzoate Chemical compound CC(C)CCCCCCCOC(=O)C1=CC=C(O)C=C1 ZYQIUVQBZWVFRE-UHFFFAOYSA-N 0.000 description 1
- XAIVUDQXALPCBH-UHFFFAOYSA-N 90cqx661te Chemical compound [Na+].CC12C(=O)[C-](C(=O)C)C(=O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O XAIVUDQXALPCBH-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 108010001478 Bacitracin Proteins 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- MOZDKDIOPSPTBH-UHFFFAOYSA-N Benzyl parahydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OCC1=CC=CC=C1 MOZDKDIOPSPTBH-UHFFFAOYSA-N 0.000 description 1
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- LDJORZUEXOLAFM-UHFFFAOYSA-M C1(=CC=CC=C1)S(=O)(=O)[O-].C1(=CC=CC=C1)S(=O)(=O)OCCCCCCCCCCCC.C(CCCCCCCCCCC)[Na].[Na+] Chemical compound C1(=CC=CC=C1)S(=O)(=O)[O-].C1(=CC=CC=C1)S(=O)(=O)OCCCCCCCCCCCC.C(CCCCCCCCCCC)[Na].[Na+] LDJORZUEXOLAFM-UHFFFAOYSA-M 0.000 description 1
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- CXRFDZFCGOPDTD-UHFFFAOYSA-M Cetrimide Chemical compound [Br-].CCCCCCCCCCCCCC[N+](C)(C)C CXRFDZFCGOPDTD-UHFFFAOYSA-M 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 239000004287 Dehydroacetic acid Substances 0.000 description 1
- 206010012444 Dermatitis diaper Diseases 0.000 description 1
- PQUCIEFHOVEZAU-UHFFFAOYSA-N Diammonium sulfite Chemical compound [NH4+].[NH4+].[O-]S([O-])=O PQUCIEFHOVEZAU-UHFFFAOYSA-N 0.000 description 1
- 208000003105 Diaper Rash Diseases 0.000 description 1
- MDNWOSOZYLHTCG-UHFFFAOYSA-N Dichlorophen Chemical compound OC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1O MDNWOSOZYLHTCG-UHFFFAOYSA-N 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 description 1
- XPJVKCRENWUEJH-UHFFFAOYSA-N Isobutylparaben Chemical compound CC(C)COC(=O)C1=CC=C(O)C=C1 XPJVKCRENWUEJH-UHFFFAOYSA-N 0.000 description 1
- FEXQDZTYJVXMOS-UHFFFAOYSA-N Isopropyl benzoate Chemical compound CC(C)OC(=O)C1=CC=CC=C1 FEXQDZTYJVXMOS-UHFFFAOYSA-N 0.000 description 1
- CMHMMKSPYOOVGI-UHFFFAOYSA-N Isopropylparaben Chemical compound CC(C)OC(=O)C1=CC=C(O)C=C1 CMHMMKSPYOOVGI-UHFFFAOYSA-N 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- MQHWFIOJQSCFNM-UHFFFAOYSA-L Magnesium salicylate Chemical compound [Mg+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O MQHWFIOJQSCFNM-UHFFFAOYSA-L 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000366182 Melaleuca alternifolia Species 0.000 description 1
- QWZLBLDNRUUYQI-UHFFFAOYSA-M Methylbenzethonium chloride Chemical compound [Cl-].CC1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 QWZLBLDNRUUYQI-UHFFFAOYSA-M 0.000 description 1
- RZCHTMXTKQHYDT-UHFFFAOYSA-N N-Lactoyl ethanolamine Chemical compound CC(O)C(=O)NCCO RZCHTMXTKQHYDT-UHFFFAOYSA-N 0.000 description 1
- PVCJKHHOXFKFRP-UHFFFAOYSA-N N-acetylethanolamine Chemical compound CC(=O)NCCO PVCJKHHOXFKFRP-UHFFFAOYSA-N 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 description 1
- YYVFXSYQSOZCOQ-UHFFFAOYSA-N Oxyquinoline sulfate Chemical compound [O-]S([O-])(=O)=O.C1=C[NH+]=C2C(O)=CC=CC2=C1.C1=C[NH+]=C2C(O)=CC=CC2=C1 YYVFXSYQSOZCOQ-UHFFFAOYSA-N 0.000 description 1
- 229920003072 Plasdone™ povidone Polymers 0.000 description 1
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- 108010020346 Polyglutamic Acid Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 101150075681 SCL1 gene Proteins 0.000 description 1
- 241001398042 Serica Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 239000004288 Sodium dehydroacetate Substances 0.000 description 1
- 239000004280 Sodium formate Substances 0.000 description 1
- KSQXVLVXUFHGJQ-UHFFFAOYSA-M Sodium ortho-phenylphenate Chemical compound [Na+].[O-]C1=CC=CC=C1C1=CC=CC=C1 KSQXVLVXUFHGJQ-UHFFFAOYSA-M 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- 239000004283 Sodium sorbate Substances 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000007244 Zea mays Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- UOZDOLIXBYLRAC-UHFFFAOYSA-L [2-hydroxy-3-(trimethylazaniumyl)propyl]-trimethylazanium;diiodide Chemical compound [I-].[I-].C[N+](C)(C)CC(O)C[N+](C)(C)C UOZDOLIXBYLRAC-UHFFFAOYSA-L 0.000 description 1
- NBVZMBLJRHUOJR-UHFFFAOYSA-N [amino-[4-[6-[4-[amino(azaniumylidene)methyl]phenoxy]hexoxy]phenyl]methylidene]azanium;2-hydroxyethanesulfonate Chemical compound OCCS(O)(=O)=O.OCCS(O)(=O)=O.C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 NBVZMBLJRHUOJR-UHFFFAOYSA-N 0.000 description 1
- TWIIVLKQFJBFPW-UHFFFAOYSA-N acetaminosalol Chemical compound C1=CC(NC(=O)C)=CC=C1OC(=O)C1=CC=CC=C1O TWIIVLKQFJBFPW-UHFFFAOYSA-N 0.000 description 1
- 229950007008 acetaminosalol Drugs 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229960004220 alcloxa Drugs 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- MJWPFSQVORELDX-UHFFFAOYSA-K aluminium formate Chemical compound [Al+3].[O-]C=O.[O-]C=O.[O-]C=O MJWPFSQVORELDX-UHFFFAOYSA-K 0.000 description 1
- GCVCIVDNHNBFMS-UHFFFAOYSA-K aluminum;benzenesulfonic acid;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3].OS(=O)(=O)C1=CC=CC=C1.OS(=O)(=O)C1=CC=CC=C1.OS(=O)(=O)C1=CC=CC=C1 GCVCIVDNHNBFMS-UHFFFAOYSA-K 0.000 description 1
- HQQUTGFAWJNQIP-UHFFFAOYSA-K aluminum;diacetate;hydroxide Chemical compound CC(=O)O[Al](O)OC(C)=O HQQUTGFAWJNQIP-UHFFFAOYSA-K 0.000 description 1
- CSJKPFQJIDMSGF-UHFFFAOYSA-K aluminum;tribenzoate Chemical compound [Al+3].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 CSJKPFQJIDMSGF-UHFFFAOYSA-K 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940090948 ammonium benzoate Drugs 0.000 description 1
- 229940107816 ammonium iodide Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- XJMWHXZUIGHOBA-UHFFFAOYSA-N azane;propanoic acid Chemical compound N.CCC(O)=O XJMWHXZUIGHOBA-UHFFFAOYSA-N 0.000 description 1
- UAHUSJDFWAEKNV-UHFFFAOYSA-N azanium;2-hydroxybenzenesulfonate Chemical compound [NH4+].OC1=CC=CC=C1S([O-])(=O)=O UAHUSJDFWAEKNV-UHFFFAOYSA-N 0.000 description 1
- 229960003071 bacitracin Drugs 0.000 description 1
- 229930184125 bacitracin Natural products 0.000 description 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229940116224 behenate Drugs 0.000 description 1
- UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 description 1
- 229940070718 behentrimonium Drugs 0.000 description 1
- 229940075506 behentrimonium chloride Drugs 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- 229960002233 benzalkonium bromide Drugs 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- WYLQRHZSKIDFEP-UHFFFAOYSA-N benzene-1,4-dithiol Chemical compound SC1=CC=C(S)C=C1 WYLQRHZSKIDFEP-UHFFFAOYSA-N 0.000 description 1
- VEFXTGTZJOWDOF-UHFFFAOYSA-N benzene;hydrate Chemical compound O.C1=CC=CC=C1 VEFXTGTZJOWDOF-UHFFFAOYSA-N 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 1
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- KYZHGEFMXZOSJN-UHFFFAOYSA-N benzoic acid isobutyl ester Natural products CC(C)COC(=O)C1=CC=CC=C1 KYZHGEFMXZOSJN-UHFFFAOYSA-N 0.000 description 1
- UDEWPOVQBGFNGE-UHFFFAOYSA-N benzoic acid n-propyl ester Natural products CCCOC(=O)C1=CC=CC=C1 UDEWPOVQBGFNGE-UHFFFAOYSA-N 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- 229960001279 benzoxiquine Drugs 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- IBNQLYMPUGQNLN-UHFFFAOYSA-M benzyl-[2-(4-dodecanoylphenoxy)ethyl]-dimethylazanium;chloride Chemical compound [Cl-].C1=CC(C(=O)CCCCCCCCCCC)=CC=C1OCC[N+](C)(C)CC1=CC=CC=C1 IBNQLYMPUGQNLN-UHFFFAOYSA-M 0.000 description 1
- RWUKNUAHIRIZJG-AFEZEDKISA-M benzyl-dimethyl-[(z)-octadec-9-enyl]azanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC[N+](C)(C)CC1=CC=CC=C1 RWUKNUAHIRIZJG-AFEZEDKISA-M 0.000 description 1
- VGTOUOZCVUBDBV-UHFFFAOYSA-M benzyl-dimethyl-tetradecylazanium;1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1.CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 VGTOUOZCVUBDBV-UHFFFAOYSA-M 0.000 description 1
- OCBHHZMJRVXXQK-UHFFFAOYSA-M benzyl-dimethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 OCBHHZMJRVXXQK-UHFFFAOYSA-M 0.000 description 1
- 229940034794 benzylparaben Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
- XVBRCOKDZVQYAY-UHFFFAOYSA-N bronidox Chemical compound [O-][N+](=O)C1(Br)COCOC1 XVBRCOKDZVQYAY-UHFFFAOYSA-N 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 235000010237 calcium benzoate Nutrition 0.000 description 1
- 239000004301 calcium benzoate Substances 0.000 description 1
- 235000010331 calcium propionate Nutrition 0.000 description 1
- 239000004330 calcium propionate Substances 0.000 description 1
- MCFVRESNTICQSJ-RJNTXXOISA-L calcium sorbate Chemical compound [Ca+2].C\C=C\C=C\C([O-])=O.C\C=C\C=C\C([O-])=O MCFVRESNTICQSJ-RJNTXXOISA-L 0.000 description 1
- 235000010244 calcium sorbate Nutrition 0.000 description 1
- 239000004303 calcium sorbate Substances 0.000 description 1
- 229940118258 calcium undecylenate Drugs 0.000 description 1
- AVVIDTZRJBSXML-UHFFFAOYSA-L calcium;2-carboxyphenolate;dihydrate Chemical compound O.O.[Ca+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O AVVIDTZRJBSXML-UHFFFAOYSA-L 0.000 description 1
- DTFQOFKRUDOJCR-UHFFFAOYSA-L calcium;4-carboxyphenolate Chemical compound [Ca+2].OC1=CC=C(C([O-])=O)C=C1.OC1=CC=C(C([O-])=O)C=C1 DTFQOFKRUDOJCR-UHFFFAOYSA-L 0.000 description 1
- HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- SXPWTBGAZSPLHA-UHFFFAOYSA-M cetalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SXPWTBGAZSPLHA-UHFFFAOYSA-M 0.000 description 1
- 229960000228 cetalkonium chloride Drugs 0.000 description 1
- 229940073669 ceteareth 20 Drugs 0.000 description 1
- 229960000800 cetrimonium bromide Drugs 0.000 description 1
- 229960002788 cetrimonium chloride Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- AWGTVRDHKJQFAX-UHFFFAOYSA-M chloro(phenyl)mercury Chemical compound Cl[Hg]C1=CC=CC=C1 AWGTVRDHKJQFAX-UHFFFAOYSA-M 0.000 description 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 1
- 229940031956 chlorothymol Drugs 0.000 description 1
- 229960005443 chloroxylenol Drugs 0.000 description 1
- 229960003993 chlorphenesin Drugs 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229960003344 climbazole Drugs 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229940012970 copper usnate Drugs 0.000 description 1
- BJKWDVRCNOATJS-UHFFFAOYSA-L copper;4,8-diacetyl-2,9a-dimethyl-7,9-dioxodibenzofuran-1,3-diolate Chemical compound [Cu+2].CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C([O-])=C(C)C([O-])=C1C(C)=O BJKWDVRCNOATJS-UHFFFAOYSA-L 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- SCXCDVTWABNWLW-UHFFFAOYSA-M decyl-dimethyl-octylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCC SCXCDVTWABNWLW-UHFFFAOYSA-M 0.000 description 1
- 235000019258 dehydroacetic acid Nutrition 0.000 description 1
- 229940061632 dehydroacetic acid Drugs 0.000 description 1
- JEQRBTDTEKWZBW-UHFFFAOYSA-N dehydroacetic acid Chemical compound CC(=O)C1=C(O)OC(C)=CC1=O JEQRBTDTEKWZBW-UHFFFAOYSA-N 0.000 description 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000011928 denatured alcohol Substances 0.000 description 1
- 229960001378 dequalinium chloride Drugs 0.000 description 1
- LTNZEXKYNRNOGT-UHFFFAOYSA-N dequalinium chloride Chemical compound [Cl-].[Cl-].C1=CC=C2[N+](CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C)=C(C)C=C(N)C2=C1 LTNZEXKYNRNOGT-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 description 1
- 229960003887 dichlorophen Drugs 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 229940062933 dimethylsilanol hyaluronate Drugs 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 1
- GWDILONWJXSNDD-UHFFFAOYSA-N docosanoic acid;n'-propylethane-1,2-diamine Chemical compound CCCNCCN.CCCCCCCCCCCCCCCCCCCCCC(O)=O GWDILONWJXSNDD-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- XJWSAJYUBXQQDR-UHFFFAOYSA-M dodecyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)C XJWSAJYUBXQQDR-UHFFFAOYSA-M 0.000 description 1
- VICYBMUVWHJEFT-UHFFFAOYSA-N dodecyltrimethylammonium ion Chemical compound CCCCCCCCCCCC[N+](C)(C)C VICYBMUVWHJEFT-UHFFFAOYSA-N 0.000 description 1
- 229960001859 domiphen bromide Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- NSTORIOUDCABGP-UHFFFAOYSA-N ethanol;prop-1-ene Chemical compound CCO.CC=C NSTORIOUDCABGP-UHFFFAOYSA-N 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- VEVFSWCSRVJBSM-HOFKKMOUSA-N ethyl 4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 VEVFSWCSRVJBSM-HOFKKMOUSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- VUFOSBDICLTFMS-UHFFFAOYSA-M ethyl-hexadecyl-dimethylazanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)CC VUFOSBDICLTFMS-UHFFFAOYSA-M 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- VYKKDKFTDMVOBU-UHFFFAOYSA-N flusalan Chemical compound OC1=C(Br)C=C(Br)C=C1C(=O)NC1=CC=CC(C(F)(F)F)=C1 VYKKDKFTDMVOBU-UHFFFAOYSA-N 0.000 description 1
- 229950004696 flusalan Drugs 0.000 description 1
- ZGFPIGGZMWGPPW-UHFFFAOYSA-N formaldehyde;formic acid Chemical compound O=C.OC=O ZGFPIGGZMWGPPW-UHFFFAOYSA-N 0.000 description 1
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 229960000587 glutaral Drugs 0.000 description 1
- 229940096960 glycereth-18 ethylhexanoate Drugs 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 229940015043 glyoxal Drugs 0.000 description 1
- ZFSXZJXLKAJIGS-UHFFFAOYSA-N halocarban Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(NC(=O)NC=2C=CC(Cl)=CC=2)=C1 ZFSXZJXLKAJIGS-UHFFFAOYSA-N 0.000 description 1
- 229950006625 halocarban Drugs 0.000 description 1
- MZMRZONIDDFOGF-UHFFFAOYSA-M hexadecyl(trimethyl)azanium;4-methylbenzenesulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.CCCCCCCCCCCCCCCC[N+](C)(C)C MZMRZONIDDFOGF-UHFFFAOYSA-M 0.000 description 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
- 229960004867 hexetidine Drugs 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229940072106 hydroxystearate Drugs 0.000 description 1
- 229940027897 ichthammol Drugs 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 229940113094 isopropylparaben Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000002655 kraft paper Substances 0.000 description 1
- SXQFCVDSOLSHOQ-UHFFFAOYSA-N lactamide Chemical compound CC(O)C(N)=O SXQFCVDSOLSHOQ-UHFFFAOYSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229950000722 lapyrium chloride Drugs 0.000 description 1
- 229950007325 lauralkonium chloride Drugs 0.000 description 1
- 229940116261 laurtrimonium Drugs 0.000 description 1
- 229940116263 laurtrimonium chloride Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- PJJZFXPJNUVBMR-UHFFFAOYSA-L magnesium benzoate Chemical compound [Mg+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 PJJZFXPJNUVBMR-UHFFFAOYSA-L 0.000 description 1
- CQQJGTPWCKCEOQ-UHFFFAOYSA-L magnesium dipropionate Chemical compound [Mg+2].CCC([O-])=O.CCC([O-])=O CQQJGTPWCKCEOQ-UHFFFAOYSA-L 0.000 description 1
- 229940072082 magnesium salicylate Drugs 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 231100000647 material safety data sheet Toxicity 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229960004011 methenamine Drugs 0.000 description 1
- 229940095102 methyl benzoate Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 229940100485 methyl gluceth-10 Drugs 0.000 description 1
- 229940031722 methyl gluceth-20 Drugs 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- OLXYLDUSSBULGU-UHFFFAOYSA-N methyl pyridine-4-carboxylate Chemical compound COC(=O)C1=CC=NC=C1 OLXYLDUSSBULGU-UHFFFAOYSA-N 0.000 description 1
- 229960002285 methylbenzethonium chloride Drugs 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229940042472 mineral oil Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 108700019599 monomethylolglycine Proteins 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 229940094510 myristalkonium chloride Drugs 0.000 description 1
- NALMPLUMOWIVJC-UHFFFAOYSA-N n,n,4-trimethylbenzeneamine oxide Chemical compound CC1=CC=C([N+](C)(C)[O-])C=C1 NALMPLUMOWIVJC-UHFFFAOYSA-N 0.000 description 1
- NGENVFQAIKEQNS-UHFFFAOYSA-N n,n-bis(2-hydroxyethyl)undec-10-enamide Chemical compound OCCN(CCO)C(=O)CCCCCCCCC=C NGENVFQAIKEQNS-UHFFFAOYSA-N 0.000 description 1
- ISTASGAHDLTQRU-UHFFFAOYSA-N n-(2-hydroxyethyl)undec-10-enamide Chemical compound OCCNC(=O)CCCCCCCCC=C ISTASGAHDLTQRU-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 229940094512 nonoxynol-12 Drugs 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical class C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 229940053549 olealkonium chloride Drugs 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- 229960001257 oxyquinoline sulfate Drugs 0.000 description 1
- 229940070805 p-chloro-m-cresol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229940106026 phenoxyisopropanol Drugs 0.000 description 1
- GJLNWLVPAHNBQN-UHFFFAOYSA-N phenyl 4-hydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OC1=CC=CC=C1 GJLNWLVPAHNBQN-UHFFFAOYSA-N 0.000 description 1
- FCJSHPDYVMKCHI-UHFFFAOYSA-N phenyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OC1=CC=CC=C1 FCJSHPDYVMKCHI-UHFFFAOYSA-N 0.000 description 1
- 229960000969 phenyl salicylate Drugs 0.000 description 1
- 229940096826 phenylmercuric acetate Drugs 0.000 description 1
- 229960000247 phenylmercuric borate Drugs 0.000 description 1
- VUXSPDNLYQTOSY-UHFFFAOYSA-N phenylmercuric borate Chemical compound OB(O)O[Hg]C1=CC=CC=C1 VUXSPDNLYQTOSY-UHFFFAOYSA-N 0.000 description 1
- ZXFQZMVPEYERPI-UHFFFAOYSA-M phenylmercury(1+);benzoate Chemical compound C=1C=CC=CC=1C(=O)O[Hg]C1=CC=CC=C1 ZXFQZMVPEYERPI-UHFFFAOYSA-M 0.000 description 1
- PUPHNPSAIJQNEE-UHFFFAOYSA-M phenylmercury(1+);bromide Chemical compound Br[Hg]C1=CC=CC=C1 PUPHNPSAIJQNEE-UHFFFAOYSA-M 0.000 description 1
- PETXWIMJICIQTQ-UHFFFAOYSA-N phenylmethoxymethanol Chemical compound OCOCC1=CC=CC=C1 PETXWIMJICIQTQ-UHFFFAOYSA-N 0.000 description 1
- 229950005358 pidolic acid Drugs 0.000 description 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
- 229940081510 piroctone olamine Drugs 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 229920006294 polydialkylsiloxane Polymers 0.000 description 1
- 229940099549 polyglycerin-3 Drugs 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 235000010235 potassium benzoate Nutrition 0.000 description 1
- 239000004300 potassium benzoate Substances 0.000 description 1
- 229940103091 potassium benzoate Drugs 0.000 description 1
- PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 description 1
- 239000001521 potassium lactate Substances 0.000 description 1
- 235000011085 potassium lactate Nutrition 0.000 description 1
- 229960001304 potassium lactate Drugs 0.000 description 1
- RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 description 1
- 229940043349 potassium metabisulfite Drugs 0.000 description 1
- 235000010263 potassium metabisulphite Nutrition 0.000 description 1
- 229960003191 potassium methylparaben Drugs 0.000 description 1
- BWILYWWHXDGKQA-UHFFFAOYSA-M potassium propanoate Chemical compound [K+].CCC([O-])=O BWILYWWHXDGKQA-UHFFFAOYSA-M 0.000 description 1
- 235000010332 potassium propionate Nutrition 0.000 description 1
- 239000004331 potassium propionate Substances 0.000 description 1
- FRMWBRPWYBNAFB-UHFFFAOYSA-M potassium salicylate Chemical compound [K+].OC1=CC=CC=C1C([O-])=O FRMWBRPWYBNAFB-UHFFFAOYSA-M 0.000 description 1
- 229960003629 potassium salicylate Drugs 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- BHZRJJOHZFYXTO-UHFFFAOYSA-L potassium sulfite Chemical compound [K+].[K+].[O-]S([O-])=O BHZRJJOHZFYXTO-UHFFFAOYSA-L 0.000 description 1
- 235000019252 potassium sulphite Nutrition 0.000 description 1
- IFIDXBCRSWOUSB-UHFFFAOYSA-N potassium;1,3-dichloro-1,3,5-triazinane-2,4,6-trione Chemical compound [K+].ClN1C(=O)NC(=O)N(Cl)C1=O IFIDXBCRSWOUSB-UHFFFAOYSA-N 0.000 description 1
- HSDKCIYHTPCVAU-UHFFFAOYSA-M potassium;2-phenylphenolate Chemical compound [K+].[O-]C1=CC=CC=C1C1=CC=CC=C1 HSDKCIYHTPCVAU-UHFFFAOYSA-M 0.000 description 1
- DPMDQHINTKFMKS-UHFFFAOYSA-M potassium;4-butoxycarbonylphenolate Chemical compound [K+].CCCCOC(=O)C1=CC=C([O-])C=C1 DPMDQHINTKFMKS-UHFFFAOYSA-M 0.000 description 1
- HFTYFFXNUVBSII-UHFFFAOYSA-M potassium;4-ethoxycarbonylphenolate Chemical compound [K+].CCOC(=O)C1=CC=C([O-])C=C1 HFTYFFXNUVBSII-UHFFFAOYSA-M 0.000 description 1
- DKGFIVSGQRBSOG-UHFFFAOYSA-M potassium;4-hydroxybenzoate Chemical compound [K+].OC1=CC=C(C([O-])=O)C=C1 DKGFIVSGQRBSOG-UHFFFAOYSA-M 0.000 description 1
- MOCBTMXJPWSHOD-UHFFFAOYSA-M potassium;4-methoxycarbonylphenolate Chemical compound [K+].COC(=O)C1=CC=C([O-])C=C1 MOCBTMXJPWSHOD-UHFFFAOYSA-M 0.000 description 1
- TUMYXYVXTFDMTJ-UHFFFAOYSA-M potassium;4-propoxycarbonylphenolate Chemical compound [K+].CCCOC(=O)C1=CC=C([O-])C=C1 TUMYXYVXTFDMTJ-UHFFFAOYSA-M 0.000 description 1
- ZGJADVGJIVEEGF-UHFFFAOYSA-M potassium;phenoxide Chemical compound [K+].[O-]C1=CC=CC=C1 ZGJADVGJIVEEGF-UHFFFAOYSA-M 0.000 description 1
- 229940078492 ppg-17 Drugs 0.000 description 1
- 229940116393 ppg-20 methyl glucose ether Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- PERLTXCUPZSJTA-YTXTXJHMSA-N propan-2-yl (2e,4e)-hexa-2,4-dienoate Chemical compound C\C=C\C=C\C(=O)OC(C)C PERLTXCUPZSJTA-YTXTXJHMSA-N 0.000 description 1
- BFZNCPXNOGIELB-UHFFFAOYSA-N propan-2-yl 10-[5,6-dihexyl-2-(8-oxo-8-propan-2-yloxyoctyl)cyclohex-3-en-1-yl]dec-9-enoate Chemical compound CCCCCCC1C=CC(CCCCCCCC(=O)OC(C)C)C(C=CCCCCCCCC(=O)OC(C)C)C1CCCCCC BFZNCPXNOGIELB-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 229940096792 quaternium-15 Drugs 0.000 description 1
- UKHVLWKBNNSRRR-TYYBGVCCSA-M quaternium-15 Chemical compound [Cl-].C1N(C2)CN3CN2C[N+]1(C/C=C/Cl)C3 UKHVLWKBNNSRRR-TYYBGVCCSA-M 0.000 description 1
- 229940117359 quaternium-24 Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940094944 saccharide isomerate Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- ZLVSYODPTJZFMK-UHFFFAOYSA-M sodium 4-hydroxybenzoate Chemical compound [Na+].OC1=CC=C(C([O-])=O)C=C1 ZLVSYODPTJZFMK-UHFFFAOYSA-M 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 description 1
- 239000011697 sodium iodate Substances 0.000 description 1
- 235000015281 sodium iodate Nutrition 0.000 description 1
- 229940032753 sodium iodate Drugs 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 235000010294 sodium orthophenyl phenol Nutrition 0.000 description 1
- 229940078442 sodium p-chloro-m-cresol Drugs 0.000 description 1
- 229940087596 sodium phenolsulfonate Drugs 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- WNFHGZLVUQBPMA-MHFWOIHZSA-M sodium;(2s,3s,4s,5s)-2,3,4,5-tetrahydroxy-6-oxohexanoate Chemical compound [Na+].O=C[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O WNFHGZLVUQBPMA-MHFWOIHZSA-M 0.000 description 1
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 description 1
- BLXAGSNYHSQSRC-UHFFFAOYSA-M sodium;2-hydroxybenzenesulfonate Chemical compound [Na+].OC1=CC=CC=C1S([O-])(=O)=O BLXAGSNYHSQSRC-UHFFFAOYSA-M 0.000 description 1
- OGBHACNFHJJTQT-UHFFFAOYSA-M sodium;4-butoxycarbonylphenolate Chemical compound [Na+].CCCCOC(=O)C1=CC=C([O-])C=C1 OGBHACNFHJJTQT-UHFFFAOYSA-M 0.000 description 1
- DPHAGKRZIJHMNL-UHFFFAOYSA-M sodium;4-chloro-3-methylphenolate Chemical compound [Na+].CC1=CC([O-])=CC=C1Cl DPHAGKRZIJHMNL-UHFFFAOYSA-M 0.000 description 1
- QYNMSPKSYXPZHG-UHFFFAOYSA-M sodium;4-ethoxycarbonylphenolate Chemical compound [Na+].CCOC(=O)C1=CC=C([O-])C=C1 QYNMSPKSYXPZHG-UHFFFAOYSA-M 0.000 description 1
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
- DKYPZNSPQXLRRQ-UHFFFAOYSA-M sodium;undec-10-enoate Chemical compound [Na+].[O-]C(=O)CCCCCCCCC=C DKYPZNSPQXLRRQ-UHFFFAOYSA-M 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940057981 stearalkonium chloride Drugs 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 229940098760 steareth-2 Drugs 0.000 description 1
- 229940100458 steareth-21 Drugs 0.000 description 1
- UHCGLDSRFKGERO-UHFFFAOYSA-N strontium peroxide Chemical compound [Sr+2].[O-][O-] UHCGLDSRFKGERO-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- ILLKMACMBHTSHP-UHFFFAOYSA-N tetradecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ILLKMACMBHTSHP-UHFFFAOYSA-N 0.000 description 1
- JYKSTGLAIMQDRA-UHFFFAOYSA-N tetraglycerol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO JYKSTGLAIMQDRA-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 235000010296 thiabendazole Nutrition 0.000 description 1
- 239000004308 thiabendazole Substances 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 229960004546 thiabendazole Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 description 1
- GAAKLDANOSASAM-UHFFFAOYSA-N undec-10-enoic acid;zinc Chemical compound [Zn].OC(=O)CCCCCCCCC=C GAAKLDANOSASAM-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940004858 usnic acid Drugs 0.000 description 1
- ICTZCAHDGHPRQR-UHFFFAOYSA-N usnic acid Natural products OC1=C(C)C(O)=C(C(C)=O)C2=C1C1(C)C(O)=C(C(=O)C)C(=O)C=C1O2 ICTZCAHDGHPRQR-UHFFFAOYSA-N 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 150000003739 xylenols Chemical class 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229940118257 zinc undecylenate Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/896—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate
- A61K8/898—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/82—Compounds containing silicon
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0094—High foaming compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/201—Monohydric alcohols linear
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
- C11D3/225—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin etherified, e.g. CMC
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
Abstract
A composition, systems for dispensing the composition and methods for the use of the composition are described. The composition comprises: (A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity; (B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.
Description
FOAMABLE ALCOHOL COMPOSITIONS, SYSTEMS AND METHODS OF USE
The present invention relates to foamable alcohol compositions, systems for dispensing the compositions and methods for the use of the compositions.
Background Foamable soap products contain a significant quantity of air. While these compositions can be economically manufactured as compared with non-foamable compositions, the formulation of foamable compositions comprising a high alcohol content has generally required the compositions to be provided as aerosol products which include a propellant (e.g., hydrocarbon, fluorocarbon, compressed gas) to facilitate foaming when the composition is dispensed from an aerosol container. These aerosol compositions can also include polymeric gelling agents, moderately high molecular weight (e.g., C16 to C22) alcohols and nonionic surfactants, for example. Aerosol products are costly to manufacture because of the need for a pressurized container and the inclusion of a foaming propellant.
In the formulation of non-aerosol soap products having a high alcohol content, surfactants have been included in such compositions to facilitate some level of foaming when the compositions are dispensed through a mechanical pump or the like. Surfactants can facilitate at least some degree of initial foaming, but such non-aerosol foams are often unstable and tend to collapse as soon as they are dispensed. While some fluorochemical surfactants have been known to facilitate more stable foams in non-aerosol compositions, fluorochemical surfactants may raise environmental concerns.
There is a need to provide foamable alcohol-containing compositions that are formulated to be anti-microbial and which can be applied to the skin (e.g., the hands).
There is a need for alcohol-containing compositions that will form a stable foam in the absence of an aerosol propellant and which will deliver alcohol to the skin for rapid skin disinfection.
Within the foregoing need, it is desirable to provide foamable, low viscosity, alcohol-, containing compositions that are safe and efficacious while providing properties that may be desired by the consumer.
Summary In one aspect, the present invention provides a composition, comprising:
(A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity;
(B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.
In another aspect, the invention provides a non-aerosol foamable composition, comprising:
(A) monohydric alcohol present in the composition at a concentration from about 35% to about 99.5% by weight; (B) a dimethicone surfactant; wherein the dimethicone surfactant is selected from the group consisting of hydroxy-terminated dimethicone copolyol, hydroxyl-capped dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, silicone copolyol pelargonate, Silicone Quaternary 1, Silicone Quaternary 2 (Myristyl), sodium dimethicone copolyol acetyl methyltaurate, dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyol laurate, dimethicone copolyolamine, dimethicone copolyol benzoate, dimethicone copolyol phthalate, dimethicone copolyol undecylenate, dimethicone copolyol crosspolymer, dimethicone copolyol lactate, dimethicone propyl pg-betaine, polysilicone-10, bis-hydroxyethoxypropyl dimethicone, disodium copolyol dimethicone sulfosuccinate, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, sodium carboxydecyl copolyol dimethicone; and combinations of two or more of the foregoing; and (C) a polymeric foam builder present in an amount sufficient to provide a stable foam formed from the composition, wherein a stable foam maintains a measurable height for at least 5 seconds following creation of the foam; wherein the polymeric foam builder is selected from
The present invention relates to foamable alcohol compositions, systems for dispensing the compositions and methods for the use of the compositions.
Background Foamable soap products contain a significant quantity of air. While these compositions can be economically manufactured as compared with non-foamable compositions, the formulation of foamable compositions comprising a high alcohol content has generally required the compositions to be provided as aerosol products which include a propellant (e.g., hydrocarbon, fluorocarbon, compressed gas) to facilitate foaming when the composition is dispensed from an aerosol container. These aerosol compositions can also include polymeric gelling agents, moderately high molecular weight (e.g., C16 to C22) alcohols and nonionic surfactants, for example. Aerosol products are costly to manufacture because of the need for a pressurized container and the inclusion of a foaming propellant.
In the formulation of non-aerosol soap products having a high alcohol content, surfactants have been included in such compositions to facilitate some level of foaming when the compositions are dispensed through a mechanical pump or the like. Surfactants can facilitate at least some degree of initial foaming, but such non-aerosol foams are often unstable and tend to collapse as soon as they are dispensed. While some fluorochemical surfactants have been known to facilitate more stable foams in non-aerosol compositions, fluorochemical surfactants may raise environmental concerns.
There is a need to provide foamable alcohol-containing compositions that are formulated to be anti-microbial and which can be applied to the skin (e.g., the hands).
There is a need for alcohol-containing compositions that will form a stable foam in the absence of an aerosol propellant and which will deliver alcohol to the skin for rapid skin disinfection.
Within the foregoing need, it is desirable to provide foamable, low viscosity, alcohol-, containing compositions that are safe and efficacious while providing properties that may be desired by the consumer.
Summary In one aspect, the present invention provides a composition, comprising:
(A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity;
(B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.
In another aspect, the invention provides a non-aerosol foamable composition, comprising:
(A) monohydric alcohol present in the composition at a concentration from about 35% to about 99.5% by weight; (B) a dimethicone surfactant; wherein the dimethicone surfactant is selected from the group consisting of hydroxy-terminated dimethicone copolyol, hydroxyl-capped dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, silicone copolyol pelargonate, Silicone Quaternary 1, Silicone Quaternary 2 (Myristyl), sodium dimethicone copolyol acetyl methyltaurate, dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyol laurate, dimethicone copolyolamine, dimethicone copolyol benzoate, dimethicone copolyol phthalate, dimethicone copolyol undecylenate, dimethicone copolyol crosspolymer, dimethicone copolyol lactate, dimethicone propyl pg-betaine, polysilicone-10, bis-hydroxyethoxypropyl dimethicone, disodium copolyol dimethicone sulfosuccinate, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, sodium carboxydecyl copolyol dimethicone; and combinations of two or more of the foregoing; and (C) a polymeric foam builder present in an amount sufficient to provide a stable foam formed from the composition, wherein a stable foam maintains a measurable height for at least 5 seconds following creation of the foam; wherein the polymeric foam builder is selected from
2 the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cetyl hydroxyethyl cellulose, ethylhydroxy ethyl cellulose, hydroxypropyl guar, polyglycerol, polyoxamer having a molecular weight of at least 100,000, polyoxamine, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-9, polyquaternium-11 to polyquaternium-47, polyvinyl methyl ether, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing; wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 50 cps at 23 C.
In still another aspect, the invention provides a system comprising a container and the composition as described above, the composition contained within the container under pressure and a propellant present within the composition.
In still another aspect, the invention provides a system comprising a dispenser comprising a reservoir and a hand pump; and the composition as described above contained within the reservoir.
In still another aspect, the invention provides a skin sanitizer comprising the composition as described above.
In still another aspect, the invention provides a pre-surgical hand scrub comprising the composition as described above.
In still another aspect, the invention provides a method for sanitizing a surface, comprising applying a volume of the composition as described above to the surface, the composition being in the form of a stable foam.
It will be appreciated that the terms used herein will be understood as being defined according to the understanding of those skilled in the art at the time of the present 2a invention. However, certain terms used herein shall be understood as having the meaning that is expressly set forth herein:
"Builder" refers to a material that can be incorporated as a component in the compositions of the invention to aid in the creation of a stable foam when the composition is dispensed from an aerosol or a non-aerosol dispenser. Compositions comprising a builder can produce lower foam densities (greater volume) as compared to the same volume of the composition in the absence of the builder.
"Emollient" as used herein refers broadly to materials which are capable of maintaining or improving the moisture level, compliance, or appearance of the skin.
"Foam" refers to a frothy mass of bubbles formed on or from a liquid (e.g., the compositions of the invention).
"HLB" means the "hydrophile-liphophile balance," or the balance between the oil soluble and water soluble moieties in a surface active molecule or surfactant.
"Polymer" as used herein refers to a natural or synthetic molecule having repetitive units and a number average molecular weight of at least 20,000.
As used herein, "poly(propylene oxide)" and "poly(ethylene oxide)" are intended to be synonymous with "polypropylene glycol" or "PPG" and "polyethylene glycol" or "PEG,"
respectively. Poly(propylene oxide) and poly(ethylene oxide) are also abbreviated herein as "PPO" and "PEO," respectively.
"Solvent", "solvent system" or "hydroalcoholic solvent" as used herein refer to the alcohol and water combination in the present invention.
"Stable," as used when referring to a foamed composition, refers to foam that maintains a measurable height for a period of time of at least about 5 seconds following creation of the foam (e.g., by shaking the composition or by dispensing the composition from an aerosol
In still another aspect, the invention provides a system comprising a container and the composition as described above, the composition contained within the container under pressure and a propellant present within the composition.
In still another aspect, the invention provides a system comprising a dispenser comprising a reservoir and a hand pump; and the composition as described above contained within the reservoir.
In still another aspect, the invention provides a skin sanitizer comprising the composition as described above.
In still another aspect, the invention provides a pre-surgical hand scrub comprising the composition as described above.
In still another aspect, the invention provides a method for sanitizing a surface, comprising applying a volume of the composition as described above to the surface, the composition being in the form of a stable foam.
It will be appreciated that the terms used herein will be understood as being defined according to the understanding of those skilled in the art at the time of the present 2a invention. However, certain terms used herein shall be understood as having the meaning that is expressly set forth herein:
"Builder" refers to a material that can be incorporated as a component in the compositions of the invention to aid in the creation of a stable foam when the composition is dispensed from an aerosol or a non-aerosol dispenser. Compositions comprising a builder can produce lower foam densities (greater volume) as compared to the same volume of the composition in the absence of the builder.
"Emollient" as used herein refers broadly to materials which are capable of maintaining or improving the moisture level, compliance, or appearance of the skin.
"Foam" refers to a frothy mass of bubbles formed on or from a liquid (e.g., the compositions of the invention).
"HLB" means the "hydrophile-liphophile balance," or the balance between the oil soluble and water soluble moieties in a surface active molecule or surfactant.
"Polymer" as used herein refers to a natural or synthetic molecule having repetitive units and a number average molecular weight of at least 20,000.
As used herein, "poly(propylene oxide)" and "poly(ethylene oxide)" are intended to be synonymous with "polypropylene glycol" or "PPG" and "polyethylene glycol" or "PEG,"
respectively. Poly(propylene oxide) and poly(ethylene oxide) are also abbreviated herein as "PPO" and "PEO," respectively.
"Solvent", "solvent system" or "hydroalcoholic solvent" as used herein refer to the alcohol and water combination in the present invention.
"Stable," as used when referring to a foamed composition, refers to foam that maintains a measurable height for a period of time of at least about 5 seconds following creation of the foam (e.g., by shaking the composition or by dispensing the composition from an aerosol
3 or non-aerosol dispenser at ambient temperature). The stability of a particular foam may further be expressed in terms of the height of the foam after a measured period of time (e.g., 6 mm after 1 minute). Foam height measurements are further discussed in the Examples.
Those skilled in the art will more fully understand the various features and aspect of the invention upon consideration of the remainder of the disclosure, including the Detailed Description, the Examples and the appended claims.
Detailed Description The invention provides a foamable composition comprised of alcohol, surfactant and builder. The compositions of the invention may be aqueous compositions.
Optional ingredients such as antimicrobials and/or emollients, for example, may be included to provide or enhance the properties of the compositions. The compositions of the invention provide the benefits of a foam for the disinfection of skin by providing a composition with a sheer thinning viscosity that is better than that for gelled compositions and which can be more easily rubbed onto sensitive tissue. Additionally, the compositions of the invention generally will dry quicker than a gel following application to a surface such as the hands, for example.
Alcohol The compositions of the invention will include at least one alcohol that provides the ability to rapidly kill a broad spectrum of microbes. The compositions of the invention are suitable for use on the skin or other surfaces and may be used as a disinfectant for the hands, for example. In embodiments of the invention, the alcohol or alcohols are monohydric alcohols. Typically, the compositions of the invention comprise alcohols having lower hydrocarbon chain lengths such as C2 to C4 alcohols. In some embodiments, the compositions of the invention comprise a single alcohol. In other embodiments, a blend of two or more alcohols may be present. In some embodiments, the alcohol will consist of ethanol. In still other embodiments, the alcohol will consist of propanol (e.g., n-
Those skilled in the art will more fully understand the various features and aspect of the invention upon consideration of the remainder of the disclosure, including the Detailed Description, the Examples and the appended claims.
Detailed Description The invention provides a foamable composition comprised of alcohol, surfactant and builder. The compositions of the invention may be aqueous compositions.
Optional ingredients such as antimicrobials and/or emollients, for example, may be included to provide or enhance the properties of the compositions. The compositions of the invention provide the benefits of a foam for the disinfection of skin by providing a composition with a sheer thinning viscosity that is better than that for gelled compositions and which can be more easily rubbed onto sensitive tissue. Additionally, the compositions of the invention generally will dry quicker than a gel following application to a surface such as the hands, for example.
Alcohol The compositions of the invention will include at least one alcohol that provides the ability to rapidly kill a broad spectrum of microbes. The compositions of the invention are suitable for use on the skin or other surfaces and may be used as a disinfectant for the hands, for example. In embodiments of the invention, the alcohol or alcohols are monohydric alcohols. Typically, the compositions of the invention comprise alcohols having lower hydrocarbon chain lengths such as C2 to C4 alcohols. In some embodiments, the compositions of the invention comprise a single alcohol. In other embodiments, a blend of two or more alcohols may be present. In some embodiments, the alcohol will consist of ethanol. In still other embodiments, the alcohol will consist of propanol (e.g., n-
4 propanol and/or isopropanol). In still other embodiments, the alcohol will consist of butanol (e.g., n-butanol, sec-butanol and tert-butanol). In some embodiments the alcohol is dissolved in water to provide an alcohol-water solvent.
Embodiments of the invention may comprise compositions having an alcohol content between about 35% and about 99.5% by weight. In some embodiments, the compositions of the invention will have an alcohol content within the range from about 60%
to about 80%. Compositions having an alcohol content within the foregoing ranges typically provide an efficacious bacterial kill.
Surfactants At least one surfactant is present in the compositions of the invention. In some embodiments, surfactant may be present in the compositions of the invention at concentration ranges from about 0.1% to about 10% by weight, based on the total weight of the composition, In some embodiments, the surfactant may be present in a composition at a concentration ranging from about 0.5% to about 5% by weight, based on the total weight of the composition. Those skilled in the art will appreciate that certain surfactants may impart a tacky or even a greasy feel to a composition when the surfactant concentration is greater than 5% by weight. While such surfactant concentrations are contemplated as within the scope of the invention, the skilled artisan may wish to consider the cosmetic effects of surfactant concentrations when formulating a composition for use by the consumer. In some embodiments, the compositions of the invention are formulated with non-fluorinated surfactants and without the need for fluorochemical propellants.
Specific surfactants useful in the invention include dimethicone surfactants.
Examples of dimethicone surfactants include dimethicone copolyols - a polymer of dimethylsiloxane with polyoxyethylene (PEO) and/or polyoxypropylene (PPO) side chains. In some embodiments, these surfactants can be hydroxyl, methoxy or butoxy terminated, and the molar ratio of PEO to PPO (PEO/PPO) can range from 0/50 to 50/0 and the molecular weight of the dimethicone portion can range from 200 to 20,000. The surfactants used in the invention can comprise specific dimethicone surfactants. Specific surfactants suitable
Embodiments of the invention may comprise compositions having an alcohol content between about 35% and about 99.5% by weight. In some embodiments, the compositions of the invention will have an alcohol content within the range from about 60%
to about 80%. Compositions having an alcohol content within the foregoing ranges typically provide an efficacious bacterial kill.
Surfactants At least one surfactant is present in the compositions of the invention. In some embodiments, surfactant may be present in the compositions of the invention at concentration ranges from about 0.1% to about 10% by weight, based on the total weight of the composition, In some embodiments, the surfactant may be present in a composition at a concentration ranging from about 0.5% to about 5% by weight, based on the total weight of the composition. Those skilled in the art will appreciate that certain surfactants may impart a tacky or even a greasy feel to a composition when the surfactant concentration is greater than 5% by weight. While such surfactant concentrations are contemplated as within the scope of the invention, the skilled artisan may wish to consider the cosmetic effects of surfactant concentrations when formulating a composition for use by the consumer. In some embodiments, the compositions of the invention are formulated with non-fluorinated surfactants and without the need for fluorochemical propellants.
Specific surfactants useful in the invention include dimethicone surfactants.
Examples of dimethicone surfactants include dimethicone copolyols - a polymer of dimethylsiloxane with polyoxyethylene (PEO) and/or polyoxypropylene (PPO) side chains. In some embodiments, these surfactants can be hydroxyl, methoxy or butoxy terminated, and the molar ratio of PEO to PPO (PEO/PPO) can range from 0/50 to 50/0 and the molecular weight of the dimethicone portion can range from 200 to 20,000. The surfactants used in the invention can comprise specific dimethicone surfactants. Specific surfactants suitable
5 -for use in embodiments of the invention include, without limitation, methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 3000;
dimethicone with a pendant ether of 35/65 (w/w) polyethylene glycol /
polypropylene glycol copolymer having a combined average molecular weight of about 7,000;
dimethicone copolyol with 18/18 (molar ratio) polyethylene glycol /
polypropylene glycol;
a dimethicone copolyol with 17/18 (molar ratio) polyethylene glycol /
polypropylene glycol; a dimethicone copolyol with polyethylene glycol / polypropylene glycol - methoxy terminated having an average molecular weight of about 20,000 and a HLB of 9-12;
dimethicone copolyol with a methoxy- terminated polyethylene glycol having a combined average molecular weight of about 3000; dimethicone copolyol with a methoxy-terminated polyethylene glycol having a combined average molecular weight of about 6000; dimethicone copolyol with a hydroxy terminated polyethylene glycol having a combined average molecular weight of about 5000 with an HLB of 13-17;
dimethicone copolyol lactate; silicone copolyol pelargonate; hydroxyl-capped dimethicone copolyol;
hydroxyl-terminated polyethylene glycol-12 dimethicone; dimethicone copolyol laurate;
Silicone Quaternary 1; hydroxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 4000; methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 600; Silicone Quaternary 2 (Myristyl); sodium dimethicone copolyol acetyl methyltaurate; butoxy-terminated poly(propylene oxide) dimethicone having an average molecular weight of about 3,000;
and silicone copolyol isostearate.
Additionally, the following surfactants may be useful in the invention:
dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethocone copolyol almondate, dimethicone copolyolamine, dimethicone copolyol avocadoate, dimethicone copolyol beeswax, dimethicone copolyol behenate, dimethicone copolyol benzoate, dimethicone copolyol bishydroxy ethylamine, dimethicone copolyol borageate, dimethicone copolyol butyl ether, dimethicone copolyol cocoa butterate, dimethicone copolyol crosspolymer, dimethicone copolyol dhupa butterate, dimethicone copolyol ethyl ether, dimethicone copolyol hydroxy stearate, dimethicone copolyol isostearate, dimethicone copolyol kokum butterate, dimethicone copolyol lactate, dimethicone copolyol laurate, dimethicone copolyol mango butterate,
dimethicone with a pendant ether of 35/65 (w/w) polyethylene glycol /
polypropylene glycol copolymer having a combined average molecular weight of about 7,000;
dimethicone copolyol with 18/18 (molar ratio) polyethylene glycol /
polypropylene glycol;
a dimethicone copolyol with 17/18 (molar ratio) polyethylene glycol /
polypropylene glycol; a dimethicone copolyol with polyethylene glycol / polypropylene glycol - methoxy terminated having an average molecular weight of about 20,000 and a HLB of 9-12;
dimethicone copolyol with a methoxy- terminated polyethylene glycol having a combined average molecular weight of about 3000; dimethicone copolyol with a methoxy-terminated polyethylene glycol having a combined average molecular weight of about 6000; dimethicone copolyol with a hydroxy terminated polyethylene glycol having a combined average molecular weight of about 5000 with an HLB of 13-17;
dimethicone copolyol lactate; silicone copolyol pelargonate; hydroxyl-capped dimethicone copolyol;
hydroxyl-terminated polyethylene glycol-12 dimethicone; dimethicone copolyol laurate;
Silicone Quaternary 1; hydroxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 4000; methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 600; Silicone Quaternary 2 (Myristyl); sodium dimethicone copolyol acetyl methyltaurate; butoxy-terminated poly(propylene oxide) dimethicone having an average molecular weight of about 3,000;
and silicone copolyol isostearate.
Additionally, the following surfactants may be useful in the invention:
dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethocone copolyol almondate, dimethicone copolyolamine, dimethicone copolyol avocadoate, dimethicone copolyol beeswax, dimethicone copolyol behenate, dimethicone copolyol benzoate, dimethicone copolyol bishydroxy ethylamine, dimethicone copolyol borageate, dimethicone copolyol butyl ether, dimethicone copolyol cocoa butterate, dimethicone copolyol crosspolymer, dimethicone copolyol dhupa butterate, dimethicone copolyol ethyl ether, dimethicone copolyol hydroxy stearate, dimethicone copolyol isostearate, dimethicone copolyol kokum butterate, dimethicone copolyol lactate, dimethicone copolyol laurate, dimethicone copolyol mango butterate,
6 dimethicone copolyol meadowfoamate, dimethicone copolyol methyl ether, dimethicone copolyol mohwa butterate, dimethicone copolyol octyldodecyl citrate, dimethicone copolyol olivate, dimethicone copolyol phosphate, dimethicone copolyol phthalate, dimethicone copolyol sal butterate, dimethicone copolyol shea butterate, dimethicone copolyol stearate, dimethicone copolyol undecylenate, dimethicone hydroxypropyl trimonium chloride, dimethicone propyl pg-betaine, polysilicone-10, polysilicone-8, dimethcone propylethylenediamine behenate, amino bispropyl dimethicone aminoethylaminopropyl dimethicone, behentrimonium dimethicone copolyol phthalate, bis-aminopropyl copolyol aminopropyl dimethicone, bis-hydroxyethoxypropyl dimethicone, cetyl triethylmonium dimethicone copolyol succinate, dimethicone copolyol sulfate, dimethicone copolyol phosphate, dimethicone polyglycerol, disodium copolyol dimethicone sulfosuccinate, copolyol polydimethylsiloxyethyl dimethicone, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, copolyol oleyl ether dimethicone, sodium carboxydecyl copolyol dimethicone.
Combinations of two or more of the foregoing dimethicone surfactants in a single composition are also contemplated within the scope of the invention Builder At least one builder may be included in the compositions of the invention in order to stabilize the foams produced from the compositions when the compositions are shaken, or when they are dispensed from either an aerosol or a non-aerosol dispenser. In some embodiments, the inclusion of certain builders can provide cosmetic attributes to the compositions of the invention. Suitable builders can include one or more of the following:
poly(ethylene oxide), hydroxyethyl cellulose, hydroxypropyl cellulose. In some embodiments, the builder will comprise only one of the foregoing. In other embodiments, the builder will comprise a combination of two or more of the foregoing builder. In some embodiments, the builder will comprise a poly(ethylene oxide) having an average molecular weight in the range from about 200,000 to about 4,000,000. One poly(ethylene oxide) suitable for use in the compositions of the invention is that know under the
Combinations of two or more of the foregoing dimethicone surfactants in a single composition are also contemplated within the scope of the invention Builder At least one builder may be included in the compositions of the invention in order to stabilize the foams produced from the compositions when the compositions are shaken, or when they are dispensed from either an aerosol or a non-aerosol dispenser. In some embodiments, the inclusion of certain builders can provide cosmetic attributes to the compositions of the invention. Suitable builders can include one or more of the following:
poly(ethylene oxide), hydroxyethyl cellulose, hydroxypropyl cellulose. In some embodiments, the builder will comprise only one of the foregoing. In other embodiments, the builder will comprise a combination of two or more of the foregoing builder. In some embodiments, the builder will comprise a poly(ethylene oxide) having an average molecular weight in the range from about 200,000 to about 4,000,000. One poly(ethylene oxide) suitable for use in the compositions of the invention is that know under the
7 designation POLYOXTM and commercially available from Dow Chemical Canada Inc., Sarnia, Ontario. Suitable POLYOX compositions include those designated as "WSR
N12K" having an average molecular weight of 1,000,000; "WSR-301" having an average molecular weight of 4,000,000; "WSR N6OK" having an average molecular weight of 2,000,000; and "WSR N-80" having an average molecular weight of 200,000.
The builder, when included in the compositions of the invention, may be present at concentrations less than or equal to about 0.1%. In some embodiments, the builder is present in the composition at concentrations of about 0.06%.
In general, the builder enhances the stability of the foam produced when the composition , of the invention is shaken or when the composition is dispensed. Builders suitable for use in the invention will include those that provide or enhance the stability of the foam ¨ i.e., those that provide a measurable foam height over at least about 5 seconds following the creation of the foam. In some embodiments, the builder is soluble in the alcohol that is used in the compositions of the invention. In some embodiments, the builder will be swellable within the alcohol. In still other embodiments, the builder can be characterized as dispersible in the alcohol.
In some embodiments, suitable foam builders include compounds comprising high molecular weight polymers. In some embodiments, these polymers are alcohol or hydroalcoholic soluble. Specific polymers useful in the invention include, without limitation: Poly(ethylene oxide) (molecular wt of 100,000 to 10,000,000), high molecular weight poly(ethylene oxide - poly(propylene oxide) copolymers, hydroxyethyl cellulose, hydroxypropyl cellulose. When present, the polymer will be at a concentration of between about 0.001 and about 5%. In some embodiments, the polymer concentration will be between about 0.01% and about 0.5%.
Polymers within the following classes can be useful as builders in the compositions of the invention: hydroxypropyl guar, polyquaternium-4, polyquaternium-10, cetyl hydroxyethylcellulose, ethylhydroxy ethyl cellulose, polyglycerol, high molecular wt.
polyoxamer, high molecular wt. polyoxamine, polyacrylamide, high molecular wt
N12K" having an average molecular weight of 1,000,000; "WSR-301" having an average molecular weight of 4,000,000; "WSR N6OK" having an average molecular weight of 2,000,000; and "WSR N-80" having an average molecular weight of 200,000.
The builder, when included in the compositions of the invention, may be present at concentrations less than or equal to about 0.1%. In some embodiments, the builder is present in the composition at concentrations of about 0.06%.
In general, the builder enhances the stability of the foam produced when the composition , of the invention is shaken or when the composition is dispensed. Builders suitable for use in the invention will include those that provide or enhance the stability of the foam ¨ i.e., those that provide a measurable foam height over at least about 5 seconds following the creation of the foam. In some embodiments, the builder is soluble in the alcohol that is used in the compositions of the invention. In some embodiments, the builder will be swellable within the alcohol. In still other embodiments, the builder can be characterized as dispersible in the alcohol.
In some embodiments, suitable foam builders include compounds comprising high molecular weight polymers. In some embodiments, these polymers are alcohol or hydroalcoholic soluble. Specific polymers useful in the invention include, without limitation: Poly(ethylene oxide) (molecular wt of 100,000 to 10,000,000), high molecular weight poly(ethylene oxide - poly(propylene oxide) copolymers, hydroxyethyl cellulose, hydroxypropyl cellulose. When present, the polymer will be at a concentration of between about 0.001 and about 5%. In some embodiments, the polymer concentration will be between about 0.01% and about 0.5%.
Polymers within the following classes can be useful as builders in the compositions of the invention: hydroxypropyl guar, polyquaternium-4, polyquaternium-10, cetyl hydroxyethylcellulose, ethylhydroxy ethyl cellulose, polyglycerol, high molecular wt.
polyoxamer, high molecular wt. polyoxamine, polyacrylamide, high molecular wt
8 =
polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-47, polyvinyl methyl ether, butylated poly vinyl pyrrolidone, hydroxypropyl methylcellulose; hydroxypropyl cellulose; crosslinked and noncrosslinked homopolymer or crosslinked and noncrosslinked copolymer containing n-vinyl lactam monomeric units.
In some embodiments, the foam builder is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl guar, ethylhydroxy ethyl cellulose, polyoxamer, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylic acid, polyquaternium-2, polyquaternium-4, polyquaternium-11, polyquaternium-15, polyquaternium-16, polyquaternium-22, polyquaternium-24, polyquaternium-28, polyquaternium-44, polyquaternium-46, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing.
Non-limiting examples of N-vinyl lactam monomers are N-vinyl-2-pyrrolidone; N-viny1-2-valerolactam; N-vinyl-2-caprolactam; and mixtures of any of the foregoing.
Typically, the poly(N-vinyl lactam) is a homopolymer of N-vinyl-2-pyrrolidone. Nonlimiting examples of comonomers useful with the aforementioned N-vinyl lactam monomers include N,N-dimethylacrylamide, acrylic acid, methacrylic acid, hydroxyethylmethacrylate, acrylamide, 2-acrylamido-2-methyl-1-propane sulfonic acid or its salt, and vinyl acetate.
While the foregoing builders can be added to the compositions of the invention individually, combinations of two or more such builders are also contemplated within the scope of the invention as well as derivatives thereof.
polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-47, polyvinyl methyl ether, butylated poly vinyl pyrrolidone, hydroxypropyl methylcellulose; hydroxypropyl cellulose; crosslinked and noncrosslinked homopolymer or crosslinked and noncrosslinked copolymer containing n-vinyl lactam monomeric units.
In some embodiments, the foam builder is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl guar, ethylhydroxy ethyl cellulose, polyoxamer, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylic acid, polyquaternium-2, polyquaternium-4, polyquaternium-11, polyquaternium-15, polyquaternium-16, polyquaternium-22, polyquaternium-24, polyquaternium-28, polyquaternium-44, polyquaternium-46, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing.
Non-limiting examples of N-vinyl lactam monomers are N-vinyl-2-pyrrolidone; N-viny1-2-valerolactam; N-vinyl-2-caprolactam; and mixtures of any of the foregoing.
Typically, the poly(N-vinyl lactam) is a homopolymer of N-vinyl-2-pyrrolidone. Nonlimiting examples of comonomers useful with the aforementioned N-vinyl lactam monomers include N,N-dimethylacrylamide, acrylic acid, methacrylic acid, hydroxyethylmethacrylate, acrylamide, 2-acrylamido-2-methyl-1-propane sulfonic acid or its salt, and vinyl acetate.
While the foregoing builders can be added to the compositions of the invention individually, combinations of two or more such builders are also contemplated within the scope of the invention as well as derivatives thereof.
9 Viscosity of Compositions The compositions of the invention will typically be of very low viscosities at 23 C. In some embodiments, the compositions of the invention can have different viscosities depending on the state of the composition. For example, a composition in a pre-dispensed condition, i.e., it is in a "pre-foamed" state in a dispenser prior to being dispensed, can have a viscosity within the range from about 0.5 to about 100 cps at 23 C. In some embodiments, the prefoam viscosities of compositions of the invention will range from about 0.5 cps to about 50 cps.
In still other embodiments, the prefoam viscosities of compositions of the invention will range from about 0.5 cps to about 20 cps. When a composition of the invention is dispensed from a non-1 0 aerosol pump-type dispenser, the 9a composition will foam, and the foam will typically be of a higher viscosity than the viscosity of the liquid "non-foamed"composition prior to dispensing. It will also be appreciated that the addition of an emollient and/or other optional ingredients (discussed herein) can also have an affect on viscosity (either positively or negatively).
Foam Density The compositions of the invention will foam when shaken of dispensed from a dispenser.
It will be appreciated that the foam densities of the compositions can vary depending on any of a variety of factors. For example, the viscosity of the unfoamed composition, discussed above, can have an effect on foam density. Moreover, the design of the dispenser or the non-aerosol pump used to deliver the foamed composition can have an effect on the foam density of the composition to the extent that the dispenser and/or the pump effect the foaming of the composition. Additionally, the amount of force applied to the pump and the relative speed at which the pump is operated when dispensing the composition can also have an effect on the foaming of the composition and its resulting viscosity.
Optional Ingredients In addition to alcohol-water, surfactant and builder, the compositions of the present invention may optionally include other ingredients such as salts, emollients, stabilizers, antimicrobials, fragrances, therapeutic agents, propellants and additional emulsifiers.
Each of these optional ingredients along with the effect each has upon the properties of the final composition is discussed below.
Emollients can optionally be added to the compositions of the invention so that the compositions can be provided in a form that is capable of increasing the moisture content of the stratum corneum when the composition is applied to a user's hands, for example.
Emollients are generally separated into two broad classes based on their function. The first class of emollients function by forming an occlusive barrier to prevent water evaporation from the stratum corneum. The second class of emollients penetrate into the stratum comeum and physically bind water to prevent evaporation. The first class of emollients is subdivided into compounds which are waxes at room temperature and compounds which are liquid oils. The second class of emollients includes those which are water soluble and are often referred to as humectants.
As referred to herein, the alcohol-water, surfactant and builder components used in the compositions of the invention are separate and distinct from components identified as emollients and optionally added to the composition. Emollients may be added to the compositions in addition to the aforementioned silicone block surfactants and builder compounds which may also aid in maintaining or improving the skin condition of the user.
In some embodiments, added emollients may be included the compositions of the invention at a concentration between about 0 and about 30% by weight. In some embodiments, the added emollient can be present in the composition at a concentration between about 0.5% and about 20%. In still other embodiments, the emollient concentration can be between about 1% and about 12% by weight. Suitable emollients may be selected from any of the classes known in the art. A general list of useful emollients appears, for example, in U.S. Patent No. 4,478,853 and in EPO
patent application 0 522 624A1 as well as in the CTFA Cosmetic Ingredient Handbook published by The Cosmetic, Toiletry, and Fragrance Association, Wash. D.C. (1992) under the listings "Skin Conditioning agents," "emollients," "humectants,"
"miscellaneous" and "occlusive."
In some embodiments, suitable emollients may be chosen from the following nonlimiting list of general emollients, occlusive emollients and humectants. Examples of general emollients include short chain alkyl or aryl esters (C1-C6) of long chain straight or branched chain alkyl or alkenyl alcohols or acids (C8-C32) and their polyethoxylated derivatives; short chain alkyl or aryl ester (CI-C6) of C4-C12 diacids or diols optionally substituted in available positions by ¨OH; alkyl or aryl C1-C10 esters of glycerol, pentaerytluitol, ethylene glycol, propylene glycol, as well as polyethoxylated derivatives of these and polyethylene glycol; C12-C22 alkyl esters or ethers of polypropylene; C12-C22 alkyl esters or ethers of polypropylene/polyethylene glycol copolymer.
Examples of occlusive emollients include cyclic and linear dimethicones;
polydialkylsiloxanes; polyaryialkylsiloxanes; long chain (Cs-C36) alkyl and alkenyl esters of long straight or branched chain alkyl or alkenyl alcohols or acids; long chain (Cs-C36) alkyl and alkenyl amides of long straight or branched chain (C8-C36) alkyl or alkenyl amines or acids; hydrocarbons including straight and branched chain alkanes and alkenes such as squalene, squalane and mineral oil; jojoba oil; polysiloxane polyalkylene copolymers; short chain alkyl or aryl esters (C1-C36) of C12-C22 diacids or diols optionally substituted in available positions by OH such as diisopropyl dimer dilinoleate; and C12-C22 alkyl and alkenyl alcohols; long chain alkyl or aryl esters (C8-C36) of C12-C22 diacides or diols optionally substituted in available positions by -OH, such as diisostearyl dimer dilinoleate; lanolin and lanolin derivatives; and beeswax and its derivatives.
Non-limiting examples of preferred humectant type emollients include glycerol, polyglycerols (including:diglycerol, triglycerol, polyglycerin-3, tetraglycerol, hexaglycerol, decaglycerols) propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol (PEG-2 to PEG-45M, preferably a molecular weight between about 300 and 1,000), sorbitol, polyhydric alcohol ethoxylates (e.g. sorbeth-6, sorbeth-30, glycereth-1 to glycereth-31) methoxides of polyethylene glycol (Methoxy PEG-2 to Methoxy PEG-100) methoxides of polyhydric alcohol ethoxylates (e.g. glycereth-methoxide), pantothenol, gluconic acid salts and the like. Other humectant-type agents like that could also be employed include: 1,2,6-hexanetriol, acetamide mea, aluminum hydroxide, arginine pea, butoxypropanol, butylene glycol, dimethyl imidazolidinone, dimethylsilanol hyaluronate, dipotassium glycyrrhizate, erythritol, ethoxy-diglycol, fructose, glucamine, gluconic acid, glucose, glucose glutamate, glucuronic acid, glutamic acid, glycogen, glycyrrhizic acid, heilmoor clay, hexacosyl glycol, histidine, hyaluronic acid, hydrogenated honey, hydrogenated starch, hydrolysate, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydrolyzed keratin, hydrolyzed silk, hydrolyzed soy protein, hydrolyzed wheat protein, hydroxyethyl sorbitol, inositol, inositol hexa-pea, lactamide mea, lactic acid, lactitol, lactose, lysine pea, magnesium pea, maltitol, manganese pea, mannitol, mel (honey extract), menthyl pea, methyl gluceth-10, methyl gluceth-20, pea (pidolic acid), lactamide, polydextrose, polyglucuronic acid, polyglyceryl sorbitol, potassium pea, ppg-20 methyl glucose ether, ppg-38-buteth-37, saccharide isomerate, serica, silk amino acids, sodium carboxymethyl chitin, sodium lactate, sodium mannuronate methylsilanol, sodium pea, sodium pea methylsilanol, sodium polyglutamate, soluble collagen, sorbitol, sucrose, tea-lactate, tea-pea, trehalose, trilactin, urea, xylitol, zea mays, zinc pea, and combinations thereof.
The addition of one or more emollients may affect the viscosity and stability of the compositions of the present invention. In some embodiments, a single emollient may be added to the composition. In some embodiments, two or more emollients may be added to the composition. While any of a variety of emollients may be added to the formulations of the present invention, some embodiments will include wax and oil type emollients either alone or combined with water soluble emollients. In some embodiments of the invention, emollient systems can be comprised of humectants in addition to occlusive wax and oil emollients in concentrations that achieve a moisturizing effect and which maintains and improves the condition of the skin upon repeated use. Emollients may be non-comedogenic and chosen to avoid skin irritation or sensitization reactions.
In addition to the antimicrobial effects attributable to the presence of alcohol in the compositions of the present invention, one or more other antimicrobial agents ("secondary antimicrobial agents") may be added to enhance the antimicrobial properties of the compositions when they are used as pre-surgical hand scrubs or pre-surgical patient skin scrub replacements, for example. In other words, the foamed composition of the present invention can deliver a secondary antimicrobial agent to the skin. In some embodiments, the secondary antimicrobial agent is added in levels up to 10% by weight of the total composition. In some embodiments, it may be desirable to incorporate a secondary antimicrobial agent in the compositions of the invention to provide continued antimicrobial resistance to the growth or regrowth of the microorganisms following evaporation of the alcohol.
Non-limiting examples of suitable secondary antimicrobial agents include parachlorometaxylenol; triclosan; chlorhexidine and its salts such as chlorhexidine gluconate, poly hexamethylene biguanide and its salts such as poly hexamethylene biguanidine chloride, iodine, idodophors; fatty acid monoesters; poly-n-vinyl pyrrolidone-iodophors; silver oxide, silver and its salts, peroxides (e.g. hydrogen peroxide), antibiotics (e.g. neomycin, bacitracin, and polymixin B).
Additionally, other suitable ingredients can be used in the compositions of the invention to suppress the regrowth or possibly treat an infection of microorganisms, such as: 2,2-thiobis(4-chlorophenol); 4,4-isopropylidenediphenol; 5-amino-6-chloro-o-cresol;
acetaminosalol; alcloxa; aldioxa; aluminum acetate; aluminum benzoate;
aluminum diacetate; aluminum formate; aluminum phenolsulfonate; ammonium iodide;
ammonium phenolsulfonate; benzisothiazolinone; benzotriazole; benzoxiquine;
benzylparaben;
berberine chloride; boric acid; cetethyl morpholiniurn ethosulfate;
cetethyldimonium bromide; cetrimonium tosylate; cetylpyridinium chloride; chloramine-t;
chlorothymol;
cloflucarban; cocotrimonium chloride; colloidal sulfur; copper usnate;
dedmhydantoin;
dedm hydantoin dilaurate; dequalinium acetate; dequalinium chloride;
dibromopropamidine diisethionate; dichloro-m-xylenol; dichlorophene;
dichlorophenyl imidazoldioxOlan; diiodomethyltolylsulfone; dimethyl hydroxymethyl pyrazole;
dimethylaminostyryl heptyl methyl thiazolium iodide; dodecylbenzyltrimonium chloride;
domiphen bromide; ferulic acid; fluorosalan; glyoxal; hydroxymethyl dioxoazabicyclooctane; hydroxypropyl bistrimonium diiodide; ichthammol;
isodecylparaben; isopropyl sorbate; lapyrium chloride; laurtrimonium trichlorophenoxide;
lauryl iso-quinolinium bromide; lauryl isoquinolinium saccharinate;
laurylpyridinium chloride; m-cresol; mandelic acid; MDM hydantoin; MEAa-iodine; melaleuca alternifolia;
methyl-benzethonium chloride; mixed cresols; nonoxynol-12 iodine; nonoxyno1-9 iodine;
o-cresol; oxyquinoline benzoate; oxyquinoline sulfate; p-chlorophenol; p-cresol; PEG15 dedm hydantoin; PEG-15 dedm hydantoin stearate; PEG-5 dedm hydantoin; PEG-5 dedm hydantoin oleate; phenol; phenoxyethylparaben; phenyl salicylate; polymethoxy bicyclic oxazolidine; potassium iodide; potassium lactate; potassium phenoxide;
potassium troclosene; quartronium-14; quaternium-24; quaternium-8;
ricinoleamidopropyltrimonium methosulfate; sodium iodide; sodium p-chloro-m-cresol; sodium phenolsulfonate;
sodium phenoxide; sodium usnate; steapyrium chloride; strontium peroxide; tea-sorbate; tetrabutyl ammonium bromide; thiabendazole; triacetin; undecylenamide dea; undecylenamide mea;
undecylenamidopropyltrimonium methosulfate; tmdecyleneth-6; undecylenoyl peg-5 paraben; usnic acid; zinc acetate; zinc borate; zinc phenolsulfonate; zinc sulfate; zinc undecylenate; and combinations of the foregoing.
The following actives could also be of use to also reduce regrowth of microorganisms on skin: 2-bromo-2-nitropropane-1,3-dial; 4-hydroxybenzoic acid; 5-bromo-5-nitro-1,3-dioxane; 7-ethylbicyclooxazolidine; ammonium benzoate; ammonium bisulfite;
ammonium propionate; ammonium sulfite; behentrimonium chloride; benzalkonium bromide; benzalkonium chloride; benzalkonium saccharinate; benzethonium chloride;
benzoic acid; benzyl alcohol; benzylhemiformal; bromochlorophene; butyl benzoate;
butylparaben; calcium benzoate; calcium paraben; calcium propionate; calcium salicylate;
calcium sorbate; calcium undecylenate; cetalkonium chloride; cetearalkonium bromide;
cetrimonium bromide; cetrimonium chloride; chloroacetamide; chlorobutanol;
chlorophene; chloroxylenol; chlorphenesin; climbazole; dehydroacetic acid;
diazolidinyl urea; dibromohexamidine isethionate; dichlorobenzyl alcohol; dimethyl oxazolidine;
DMDM hydantoin; ethyl benzoate; ethylparaben; formaldehyde; formic acid;
glutaral;
hexamidine; hexamidine diisethionate; hexamidine paraben; hexetidine;
hydrogenated tallovvtrimonium chloride; imidazolidinyl urea; iodopropynyl butylcarbamate;
isobutyl benzoate; isobutylparaben; isopropyl benzoate; isopropyl cresols;
isopropylparaben;
lauralkonium bromide; lauralkonium chloride; laurtrimonium bromide;
laurtrimonium chloride; magnesium benzoate; magnesium propionate; magnesium salicylate; MEA
o-phenylphenate; MEA-benzoate; MEA-salicylate; MEA-undecylenate; methenamine;
methyl benzoate; methylchloroisothiazolinone; methyldibromo glutaronitrile;
methylisothiazolinone; methylparaben; myristalkonium chloride; myristalkonium saccharinate; myrtrimonium bromide; o-cymen-5-01; o-phenylphenol; olealkonium chloride; p-chloro-m-cresol; phenoxyethanol; phenoxyisopropanol; phenyl benzoate;
phenyl mercuric acetate; phenyl mercuric benzoate; phenyl mercuric borate;
phenyl mercuric bromide; phenyl mercuric chloride; phenylparaben; piroctone olamine;
polyaminopropyl biguanide; potassium benzoate; potassium butylparaben;
potassium ethylparaben; potassium metabisulfite; potassium methylparaben; potassium o-phenylphenate; potassium paraben; potassium propionate; potassium propylparaben;
potassium salicylate; potassium sorbate; potassium sulfite; propionic acid;
propyl benzoate; propylparaben; quaternium-15; salicylic acid; sodium benzoate;
sodium bisulfite; sodium butylparaben; sodium dehydroacetate; sodium ethylparaben;
sodium formate; sodium hydroxymethylglycinate; sodium iodate; sodium metabisulfite;
sodium methylparaben; sodium o-phenylphenate; sodium paraben; sodium propionate;
sodium propylparaben; sodium salicylate; sodium sorbate; sodium sulfite; sodium undecylenate;
sorbic acid; soytrimonium chloride; stearalkonium chloride; steartrimonium chloride;
tallowalkonium chloride; tallowtrimonium chloride; thimerosal; triclocarban;
triclosan;
undecylenic acid; zinc pyrithione.
The present invention further encompasses embodiments incorporating antimicrobials such as benzoyl peroxide so that the composition may be useful as an acne medication, for example. In some embodiments, the compositions of the present invention may also be formulated with barrier compounds to form barrier creams and lotions.
Materials which may be added to provide barrier protection for use as skin barriers to protect against diaper rash include but are not limited to 0.1 to 60% aldioxa, allantoin, aluminum acetate, aluminum hydroxide, bismuth subnitrate, boric acid, calamine, cellulose (microporous), cholecalciferol, cocoa butter, cod liver oil (in combination), colloidal oatmeal, cysteine hydrochloride, dexpanthenol, dimethicone, glycerin kaolin, lanolin (in combination), live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsam oil, pertrolatum, protein hydrolysate (1-leucine, 1-isoleucine, 1-methionine, 1-phenylalanine, and 1-tyrosine), racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate and zinc oxide.
In some embodiments, the compositions of the invention may comprise one or more formulations containing antifungal agents for the treatment of fimgal infections of the skin such as athlete's foot and the like.
While some embodiments will include one additional secondary antimicrobial agent, other embodiments of the invention can include two or more additional secondary antimicrobials. While the foregoing secondary antimicrobials can be added to the compositions individually or singly, combinations of two or more of the foregoing secondary antimicrobials are also contemplated within the scope of the invention.
In some embodiments, the compositions of the present invention may be formulated into non-aerosol products that can be dispensed from a reservoir using a hand-pump, for example, to dispense an amount of the composition whenever the hand pump is actuated.
The amount of the composition dispensed by the pump may or may not be metered so that the amount of composition dispensed may or may not be consistent. Moreover, the compositions of the invention are not limited to being dispensed from only one type of dispenser or through only one type of hand pump.
In some embodiments, the compositions are capable of being formulated into an aerosol foam or a mousse by addition of propellant to the composition. Suitable propellants can be chosen from chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorinated alkanes, and lower alkanes (Cl- C5) as well as nitrous oxide dimethyl ether and other solvent-soluble propellants. Suitable lower alkanes include propane, butane, and isobutane, for example. In some embodiments, the propellant can comprise a 70/30 mixture of propane/isobutane. In order to produce an aerosol composition the composition is first formulated and charged into an appropriate pressure rated container. A suitable propellant may then be added to the composition under pressure at approximately 2-30% preferably 3-20% by volume. The propellant may form a separate layer on the composition or the propellant may be emulsified or miscible in the composition.
The compositions of the invention can be used in any of a variety of applications including use as a sanitizer for application to a surface. The compositions of the invention are suitable for use on mammalian skin including the human hands. In some embodiments, the compositions may be used as a pre-surgical hand scrub. In non-aerosol formulations of the invention, the compositions may be contained in a non-aerosol dispenser equipped with a conventional hand pump, and the composition may be pumped onto the hands or other areas of the body. The pumping action required to dispense the compositions will create a discrete volume of a dispensed composition in the form of a stable foam.
Likewise, in embodiments comprising an aerosol, the aerosol formulation may be dispensed from a pressurized container in a discrete volume of foamed composition. After dispensing, the foam may be spread upon the surface of the skin to sanitize the skin, the hands or the like. While some residue may remain on the skin following evaporation of the alcohol component, the residue can comprise emollients Or the like to provide a desired cosmetic effect. Consequently, the compositions of the invention provide a means for sanitizing skin in the form of a foamable composition which does not need to be rinsed from the skin following application of the foam to the area in need of sanitization.
Alternatively, undesired residue remaining on the surface can be rinsed off with water, for example.
From the foregoing, it will be appreciated that the present invention also encompasses systems for dispensing the compositions comprising a reservoir and an amount of composition retained therein, and means for dispensing the composition from the reservoir.
The compositions of the present invention may be prepared by a variety of techniques and the ingredients may be added to one another in any order of addition. To ensure a composition of maximum stability, the components may be subjected to high shear (e.g.
homogenized) for a limited time period.
EXAMPLES
The following non-limiting Examples are provided to illustrate features of the invention.
are not intended to limit the scope of the invention. All percent amounts are weight/weight percent (wt/wt%) unless otherwise noted.
Preparation of Compositions The compositions in the Examples were prepared in 60 gram samples by combining all components in a glass jar and rolling the jar overnight, on a mechanical roller. The foam builder was introduced to the mixture by first preparing a premix of the foam builder at ranges from 0.5% to 8.0% wt/wt, prepared in water/alcohol. The appropriate weight of premix was then added to the mixture containing the other components prior to the step of mixing by rolling overnight.
According to the Material Safety Data Sheets of certain dimethicone copolyol surfactants, the surfactants are known to contain significant quantities of PEO/PPO block copolymers of the type described herein as builders. These copolymers may be byproducts of the manufacturing process for the copolyol surfactants. The surfactants and builders used in the compositions of the Examples are listed in Tables 1 and 2.
Table 1 ¨ Surfactants Trade Name INCI Name Surfactant Mfr. Mfr.
Location PEG/PPG-4/12 Goldschmidt Abil B 8852 Hopewell,VA
Dimethicone Chemical Corp.
PEG/PPG-35/65 Goldschmidt Abil B 8873 Hopewell,VA
Dimethicone 7,000MW Chemical Corp.
Dow 190 Fluidl PEG/PPG-18/18 Dow Corning Midland, MI
Dimethicone PEG-12 Dimethicone, Dow 193 Fluid2 Dow Corning Midland, MI
Hydroxyl terminated Hydroxyl capped Lambent Lambent MFF-164 Gurnee, IL
dimethicone copolyol Technologies Inc.
Lambent Lambent Quat AD Silicone Quaternary 1 Gurnee, IL
Technologies Inc.
Silicone Quaternary 2 Lambent Lambent Quat AM Gurnee, IL
(Myristyl) Technologies Inc.
Acrylic backbone polymer with Lambent Lambent Syngard 300 Gurnee, IL
dimethylsiloxane Technologies Inc.
sidechains Dimethicone copolyol Lambent Lambent Wax WS-L Gurnee, IL
Laurate Technologies Inc.
Silicone Copolyol Lambent Lambent Wax WS-p Gurnee, IL
Pelargonate Technologies Inc.
Dimethicone Copolyol PCI Pheonix Pecosil DCL Somerville, NJ
Lactate Chemical, Inc.
Sodium Dimethicone PCI Pheonix Pecosil DCT Copolyol Acetyl Somerville, NJ
Chemical, Inc.
Metlaytaurate Q2-5220 Resin Modifier3 PEG/PPG-17/18 Dow Corning Midland, MI
Dimethicone Silicone Copolyol Lambent Silwax WD-IS Gurnee, IL
Isostearate Technologies Inc.
PEG Dimethicone, Silwet 77 Methoxy Terminated, GE Silicones Midland, MI
Table 1 ¨ Surfactants Trade Name INCI Name Surfactant Mfr. Mfr. Location EO/PO, Methoxy Silwet L-7001 GE Silicones Wilton, CT
terminated 20,000MW
Silwet L-7200 Dimethicone Copolyol GE Silicones Midland, MI
PPO Dimethicone, Silwet L-7500 Butoxy Terminated, GE Silicones Midland, MI
3,000MW
PEG Dimethicone, Silwet L-7602 Methoxy Terminated, GE Silicones Wilton, CT
PEG Dimethicone, Silwet L-7604 Hydroxy Terminated, GE Silicones Midland, MI
PEG Dimethicone, Silwet L-7605 Methoxy Terminated, GE Silicones Wilton, CT
PEG Dimethicone, Silwet L-7614 Hydroxy Terminated, GE Silicones Wilton, CT
3MTm Silicones "Plus"
Polymer VS80 Polysilicone-8 3M Company St. Paul, MN
1. Dow 190 surfactant includes poly(ethylene oxide, propylene oxide) monoallyl ether acetate and polyether polyol acetate.
2. Dow 193 surfactant includes polyethylene oxide monoallyl ether.
3. Q2-5220 Resin Modifier includes poly(ethylene oxide, propylene oxide) monoallyl ether acetate; polyethylene glycol monoallyl ether acetate; and polyether polyol acetate.
Table 2 ¨ Foam Builders Trade Name Description Supplier / Mfr. Mfr.
Location Aqualon EC K100 Ethylcellulose Hercules Wilmington, DE
PEG-150 Pentaerythrityl Crothix Liquid tetrastearate (and) PEG-6 Croda Parsippany, NJ
Capric/Caprylic glycerides Economy Ecopol 120-S Hydroxypropyl Guar Polymers and Houston, TX
Chemicals Ganex Butylated Polyvinyl ISP
Wayne, NJ
P-904LC Pyrrolidone Technologies Cetyl Wilmington, Natrosol Plus Hercules hydroxyethylcellulose DE
Table 2¨ Foam Builders Trade Name Description Supplier / Mfr. Mfr.
Location International Plasdone PVP K-120 Polyvinyl Pyrrolidone Specialty Wayne, NJ
Products Pluronic Ethylene Oxide/Propylene Florham Park, BASF
F-108 Oxide Block Copolymer NJ
Pluronic Ethylene Oxide/Propylene Florham Park, BASF
F-127 Oxide Block Copolymer NJ
poly(ethylene oxide) Dow Chemical Polyox WSR N12K Midland, MI
Ave MW 1,000,000 Co.
poly(ethylene oxide) Dow Chemical Polyox WSR N6OK Midland, MI
Ave MW 2,000,000 Co.
poly(ethylene oxide) Dow Chemical Polyox WSR N-80 Midland, MI
Ave MW 200,000 Co.
poly(ethylene oxide) Dow Chemical Polyox WSR-301 Midland, MI
Ave MW 4,000,000 Co.
Polyvinyl Pyrrolidone (K Florham Park, value 90) NJ
Equipment Foam Pump ¨ A foam pump nozzle was used to generate foam from each composition.
The pump used was a pump dispenser, product Code F2, type F2-L11 255/150, available from Airspray International Inc. of North Pompano Beach, FL.
Foam Collection vial - Vials were used to collect foam from the pump dispenser while the foam height was being measured. The vials were made of glass and were of either 40 or 80 rnm height having a 25mm internal diameter and a 27mm outer diameter.
Test Methods Foam Height Test Procedure The Foam Pump was used to assess the foam forming property of the compositions. The pump was rinsed between samples with deionized water by pumping water through the pump until it came out clear. The pump dip tube was removed from the water and then pumped dry of residual water and then placed in the composition to be tested.
The pump was then pumped 3 times to prime the pump and then 3 more times to purge solution through the nozzle to ensure the system was ready. Finally, three pumps worth of foam were collected in a collection vial by pumping slowly at a speed of about 1 second for each pump. The vial containing the foam was placed on a flat surface, a timer was started and a small ruler with millimeter increments was used to measure the approximate height of the foam, ignoring the height of any remaining unfoamed composition. The time to measure the foam height usually took about 5 seconds. Any composition producing a foam which was not stable at least 5 seconds was considered unstable and rated 0 mm. The foam height was estimated to be the average height of the foam. A rating of 0 mm was given if the top of the solution was void of foam in any spot, usually the center. The foam height was recorded after 1, 3 and 5 minutes to determine the long term stability of the foam.
Foam Volume % Increase The percentage of foam volume increase over the solution volume was calculated by measuring the foam height in millimeters, subtracting 5mm from the foam height and dividing the result by 5 (the volume of the un-foamed pumped solution) and multiplying by 100%. Foam volume % increase measurements were made immediately following creation of the foam (e.g., after dispensing). Due to the difficulty in determining the exact foam surface, foam heights between 0-5 mm were reported as having a zero percent increase in foam volume.
Viscosity Viscosity in centipoise (cP) was measured at 23 C at ambient pressure using a Brookfield viscometer Model LVT equipped with a Brookfield LV spindle # 1 @ 60 rpm. All samples were allowed to equilibrate at 23 C for 24 hours prior to measurement.
The viscosity was taken at the lowest speed possible while staying within 10-100%
of the viscometer range and more preferably between 20-80% of the range. The viscosity was read after one minute of testing. In all cases the sample size and container geometry was chosen to ensure that there were no wall effects. By "wall effects" it is meant the viscosity value is not affected by the container and is essentially equivalent to the viscosity taken in an infinitely large container. For this reason lower viscosity samples required a larger sample size to accommodate the larger spindles.
Examples 1-13 Examples 1-13 were prepared using various amounts of the surfactant Dow 190;
plus a poly(ethylene oxide) (PEO) foam builder, available from Dow Chemical Company of Midland, MI, under the trade name POLY0X(TM) WSRN12K; distilled water, and an alcohol solvent. Foam height measurements according to the above test method were taken for each sample. The foam height measurements and formulations for each of the Examples are set forth in Table 3.
FoamInitial Foam Foam Foam Dow 190 Water SPA
Example Surf. 1 Amt. (Et0H/ rPA2 BuilderN Foam Height Height Height 12K Height 1 min. 3 min. 5 min.
Amt. % % IPA) Amt. % mm mm mm mm 1 1.00 0.060 43.94 55.00 - 32 2 1.00 0.060 38.94 60.00 - 32 3 1.00 0.060 35.17 63.77 - 35 4 1.00 0.060 28.94 70.00 - 34 5 1.00 0.060 23.94 75.00 - 28 26 21 17 6 1.00 0.060 18.94 80.00 - 30 29 23 14 7 1.00 0.060 43.94 - 55.00 36 35 32 28 8 1.00 0.060 34.94 - 64.00 35 _ 33 9 0.50 0.060 35.44 64.00 25 23 20 14
In still other embodiments, the prefoam viscosities of compositions of the invention will range from about 0.5 cps to about 20 cps. When a composition of the invention is dispensed from a non-1 0 aerosol pump-type dispenser, the 9a composition will foam, and the foam will typically be of a higher viscosity than the viscosity of the liquid "non-foamed"composition prior to dispensing. It will also be appreciated that the addition of an emollient and/or other optional ingredients (discussed herein) can also have an affect on viscosity (either positively or negatively).
Foam Density The compositions of the invention will foam when shaken of dispensed from a dispenser.
It will be appreciated that the foam densities of the compositions can vary depending on any of a variety of factors. For example, the viscosity of the unfoamed composition, discussed above, can have an effect on foam density. Moreover, the design of the dispenser or the non-aerosol pump used to deliver the foamed composition can have an effect on the foam density of the composition to the extent that the dispenser and/or the pump effect the foaming of the composition. Additionally, the amount of force applied to the pump and the relative speed at which the pump is operated when dispensing the composition can also have an effect on the foaming of the composition and its resulting viscosity.
Optional Ingredients In addition to alcohol-water, surfactant and builder, the compositions of the present invention may optionally include other ingredients such as salts, emollients, stabilizers, antimicrobials, fragrances, therapeutic agents, propellants and additional emulsifiers.
Each of these optional ingredients along with the effect each has upon the properties of the final composition is discussed below.
Emollients can optionally be added to the compositions of the invention so that the compositions can be provided in a form that is capable of increasing the moisture content of the stratum corneum when the composition is applied to a user's hands, for example.
Emollients are generally separated into two broad classes based on their function. The first class of emollients function by forming an occlusive barrier to prevent water evaporation from the stratum corneum. The second class of emollients penetrate into the stratum comeum and physically bind water to prevent evaporation. The first class of emollients is subdivided into compounds which are waxes at room temperature and compounds which are liquid oils. The second class of emollients includes those which are water soluble and are often referred to as humectants.
As referred to herein, the alcohol-water, surfactant and builder components used in the compositions of the invention are separate and distinct from components identified as emollients and optionally added to the composition. Emollients may be added to the compositions in addition to the aforementioned silicone block surfactants and builder compounds which may also aid in maintaining or improving the skin condition of the user.
In some embodiments, added emollients may be included the compositions of the invention at a concentration between about 0 and about 30% by weight. In some embodiments, the added emollient can be present in the composition at a concentration between about 0.5% and about 20%. In still other embodiments, the emollient concentration can be between about 1% and about 12% by weight. Suitable emollients may be selected from any of the classes known in the art. A general list of useful emollients appears, for example, in U.S. Patent No. 4,478,853 and in EPO
patent application 0 522 624A1 as well as in the CTFA Cosmetic Ingredient Handbook published by The Cosmetic, Toiletry, and Fragrance Association, Wash. D.C. (1992) under the listings "Skin Conditioning agents," "emollients," "humectants,"
"miscellaneous" and "occlusive."
In some embodiments, suitable emollients may be chosen from the following nonlimiting list of general emollients, occlusive emollients and humectants. Examples of general emollients include short chain alkyl or aryl esters (C1-C6) of long chain straight or branched chain alkyl or alkenyl alcohols or acids (C8-C32) and their polyethoxylated derivatives; short chain alkyl or aryl ester (CI-C6) of C4-C12 diacids or diols optionally substituted in available positions by ¨OH; alkyl or aryl C1-C10 esters of glycerol, pentaerytluitol, ethylene glycol, propylene glycol, as well as polyethoxylated derivatives of these and polyethylene glycol; C12-C22 alkyl esters or ethers of polypropylene; C12-C22 alkyl esters or ethers of polypropylene/polyethylene glycol copolymer.
Examples of occlusive emollients include cyclic and linear dimethicones;
polydialkylsiloxanes; polyaryialkylsiloxanes; long chain (Cs-C36) alkyl and alkenyl esters of long straight or branched chain alkyl or alkenyl alcohols or acids; long chain (Cs-C36) alkyl and alkenyl amides of long straight or branched chain (C8-C36) alkyl or alkenyl amines or acids; hydrocarbons including straight and branched chain alkanes and alkenes such as squalene, squalane and mineral oil; jojoba oil; polysiloxane polyalkylene copolymers; short chain alkyl or aryl esters (C1-C36) of C12-C22 diacids or diols optionally substituted in available positions by OH such as diisopropyl dimer dilinoleate; and C12-C22 alkyl and alkenyl alcohols; long chain alkyl or aryl esters (C8-C36) of C12-C22 diacides or diols optionally substituted in available positions by -OH, such as diisostearyl dimer dilinoleate; lanolin and lanolin derivatives; and beeswax and its derivatives.
Non-limiting examples of preferred humectant type emollients include glycerol, polyglycerols (including:diglycerol, triglycerol, polyglycerin-3, tetraglycerol, hexaglycerol, decaglycerols) propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol (PEG-2 to PEG-45M, preferably a molecular weight between about 300 and 1,000), sorbitol, polyhydric alcohol ethoxylates (e.g. sorbeth-6, sorbeth-30, glycereth-1 to glycereth-31) methoxides of polyethylene glycol (Methoxy PEG-2 to Methoxy PEG-100) methoxides of polyhydric alcohol ethoxylates (e.g. glycereth-methoxide), pantothenol, gluconic acid salts and the like. Other humectant-type agents like that could also be employed include: 1,2,6-hexanetriol, acetamide mea, aluminum hydroxide, arginine pea, butoxypropanol, butylene glycol, dimethyl imidazolidinone, dimethylsilanol hyaluronate, dipotassium glycyrrhizate, erythritol, ethoxy-diglycol, fructose, glucamine, gluconic acid, glucose, glucose glutamate, glucuronic acid, glutamic acid, glycogen, glycyrrhizic acid, heilmoor clay, hexacosyl glycol, histidine, hyaluronic acid, hydrogenated honey, hydrogenated starch, hydrolysate, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydrolyzed keratin, hydrolyzed silk, hydrolyzed soy protein, hydrolyzed wheat protein, hydroxyethyl sorbitol, inositol, inositol hexa-pea, lactamide mea, lactic acid, lactitol, lactose, lysine pea, magnesium pea, maltitol, manganese pea, mannitol, mel (honey extract), menthyl pea, methyl gluceth-10, methyl gluceth-20, pea (pidolic acid), lactamide, polydextrose, polyglucuronic acid, polyglyceryl sorbitol, potassium pea, ppg-20 methyl glucose ether, ppg-38-buteth-37, saccharide isomerate, serica, silk amino acids, sodium carboxymethyl chitin, sodium lactate, sodium mannuronate methylsilanol, sodium pea, sodium pea methylsilanol, sodium polyglutamate, soluble collagen, sorbitol, sucrose, tea-lactate, tea-pea, trehalose, trilactin, urea, xylitol, zea mays, zinc pea, and combinations thereof.
The addition of one or more emollients may affect the viscosity and stability of the compositions of the present invention. In some embodiments, a single emollient may be added to the composition. In some embodiments, two or more emollients may be added to the composition. While any of a variety of emollients may be added to the formulations of the present invention, some embodiments will include wax and oil type emollients either alone or combined with water soluble emollients. In some embodiments of the invention, emollient systems can be comprised of humectants in addition to occlusive wax and oil emollients in concentrations that achieve a moisturizing effect and which maintains and improves the condition of the skin upon repeated use. Emollients may be non-comedogenic and chosen to avoid skin irritation or sensitization reactions.
In addition to the antimicrobial effects attributable to the presence of alcohol in the compositions of the present invention, one or more other antimicrobial agents ("secondary antimicrobial agents") may be added to enhance the antimicrobial properties of the compositions when they are used as pre-surgical hand scrubs or pre-surgical patient skin scrub replacements, for example. In other words, the foamed composition of the present invention can deliver a secondary antimicrobial agent to the skin. In some embodiments, the secondary antimicrobial agent is added in levels up to 10% by weight of the total composition. In some embodiments, it may be desirable to incorporate a secondary antimicrobial agent in the compositions of the invention to provide continued antimicrobial resistance to the growth or regrowth of the microorganisms following evaporation of the alcohol.
Non-limiting examples of suitable secondary antimicrobial agents include parachlorometaxylenol; triclosan; chlorhexidine and its salts such as chlorhexidine gluconate, poly hexamethylene biguanide and its salts such as poly hexamethylene biguanidine chloride, iodine, idodophors; fatty acid monoesters; poly-n-vinyl pyrrolidone-iodophors; silver oxide, silver and its salts, peroxides (e.g. hydrogen peroxide), antibiotics (e.g. neomycin, bacitracin, and polymixin B).
Additionally, other suitable ingredients can be used in the compositions of the invention to suppress the regrowth or possibly treat an infection of microorganisms, such as: 2,2-thiobis(4-chlorophenol); 4,4-isopropylidenediphenol; 5-amino-6-chloro-o-cresol;
acetaminosalol; alcloxa; aldioxa; aluminum acetate; aluminum benzoate;
aluminum diacetate; aluminum formate; aluminum phenolsulfonate; ammonium iodide;
ammonium phenolsulfonate; benzisothiazolinone; benzotriazole; benzoxiquine;
benzylparaben;
berberine chloride; boric acid; cetethyl morpholiniurn ethosulfate;
cetethyldimonium bromide; cetrimonium tosylate; cetylpyridinium chloride; chloramine-t;
chlorothymol;
cloflucarban; cocotrimonium chloride; colloidal sulfur; copper usnate;
dedmhydantoin;
dedm hydantoin dilaurate; dequalinium acetate; dequalinium chloride;
dibromopropamidine diisethionate; dichloro-m-xylenol; dichlorophene;
dichlorophenyl imidazoldioxOlan; diiodomethyltolylsulfone; dimethyl hydroxymethyl pyrazole;
dimethylaminostyryl heptyl methyl thiazolium iodide; dodecylbenzyltrimonium chloride;
domiphen bromide; ferulic acid; fluorosalan; glyoxal; hydroxymethyl dioxoazabicyclooctane; hydroxypropyl bistrimonium diiodide; ichthammol;
isodecylparaben; isopropyl sorbate; lapyrium chloride; laurtrimonium trichlorophenoxide;
lauryl iso-quinolinium bromide; lauryl isoquinolinium saccharinate;
laurylpyridinium chloride; m-cresol; mandelic acid; MDM hydantoin; MEAa-iodine; melaleuca alternifolia;
methyl-benzethonium chloride; mixed cresols; nonoxynol-12 iodine; nonoxyno1-9 iodine;
o-cresol; oxyquinoline benzoate; oxyquinoline sulfate; p-chlorophenol; p-cresol; PEG15 dedm hydantoin; PEG-15 dedm hydantoin stearate; PEG-5 dedm hydantoin; PEG-5 dedm hydantoin oleate; phenol; phenoxyethylparaben; phenyl salicylate; polymethoxy bicyclic oxazolidine; potassium iodide; potassium lactate; potassium phenoxide;
potassium troclosene; quartronium-14; quaternium-24; quaternium-8;
ricinoleamidopropyltrimonium methosulfate; sodium iodide; sodium p-chloro-m-cresol; sodium phenolsulfonate;
sodium phenoxide; sodium usnate; steapyrium chloride; strontium peroxide; tea-sorbate; tetrabutyl ammonium bromide; thiabendazole; triacetin; undecylenamide dea; undecylenamide mea;
undecylenamidopropyltrimonium methosulfate; tmdecyleneth-6; undecylenoyl peg-5 paraben; usnic acid; zinc acetate; zinc borate; zinc phenolsulfonate; zinc sulfate; zinc undecylenate; and combinations of the foregoing.
The following actives could also be of use to also reduce regrowth of microorganisms on skin: 2-bromo-2-nitropropane-1,3-dial; 4-hydroxybenzoic acid; 5-bromo-5-nitro-1,3-dioxane; 7-ethylbicyclooxazolidine; ammonium benzoate; ammonium bisulfite;
ammonium propionate; ammonium sulfite; behentrimonium chloride; benzalkonium bromide; benzalkonium chloride; benzalkonium saccharinate; benzethonium chloride;
benzoic acid; benzyl alcohol; benzylhemiformal; bromochlorophene; butyl benzoate;
butylparaben; calcium benzoate; calcium paraben; calcium propionate; calcium salicylate;
calcium sorbate; calcium undecylenate; cetalkonium chloride; cetearalkonium bromide;
cetrimonium bromide; cetrimonium chloride; chloroacetamide; chlorobutanol;
chlorophene; chloroxylenol; chlorphenesin; climbazole; dehydroacetic acid;
diazolidinyl urea; dibromohexamidine isethionate; dichlorobenzyl alcohol; dimethyl oxazolidine;
DMDM hydantoin; ethyl benzoate; ethylparaben; formaldehyde; formic acid;
glutaral;
hexamidine; hexamidine diisethionate; hexamidine paraben; hexetidine;
hydrogenated tallovvtrimonium chloride; imidazolidinyl urea; iodopropynyl butylcarbamate;
isobutyl benzoate; isobutylparaben; isopropyl benzoate; isopropyl cresols;
isopropylparaben;
lauralkonium bromide; lauralkonium chloride; laurtrimonium bromide;
laurtrimonium chloride; magnesium benzoate; magnesium propionate; magnesium salicylate; MEA
o-phenylphenate; MEA-benzoate; MEA-salicylate; MEA-undecylenate; methenamine;
methyl benzoate; methylchloroisothiazolinone; methyldibromo glutaronitrile;
methylisothiazolinone; methylparaben; myristalkonium chloride; myristalkonium saccharinate; myrtrimonium bromide; o-cymen-5-01; o-phenylphenol; olealkonium chloride; p-chloro-m-cresol; phenoxyethanol; phenoxyisopropanol; phenyl benzoate;
phenyl mercuric acetate; phenyl mercuric benzoate; phenyl mercuric borate;
phenyl mercuric bromide; phenyl mercuric chloride; phenylparaben; piroctone olamine;
polyaminopropyl biguanide; potassium benzoate; potassium butylparaben;
potassium ethylparaben; potassium metabisulfite; potassium methylparaben; potassium o-phenylphenate; potassium paraben; potassium propionate; potassium propylparaben;
potassium salicylate; potassium sorbate; potassium sulfite; propionic acid;
propyl benzoate; propylparaben; quaternium-15; salicylic acid; sodium benzoate;
sodium bisulfite; sodium butylparaben; sodium dehydroacetate; sodium ethylparaben;
sodium formate; sodium hydroxymethylglycinate; sodium iodate; sodium metabisulfite;
sodium methylparaben; sodium o-phenylphenate; sodium paraben; sodium propionate;
sodium propylparaben; sodium salicylate; sodium sorbate; sodium sulfite; sodium undecylenate;
sorbic acid; soytrimonium chloride; stearalkonium chloride; steartrimonium chloride;
tallowalkonium chloride; tallowtrimonium chloride; thimerosal; triclocarban;
triclosan;
undecylenic acid; zinc pyrithione.
The present invention further encompasses embodiments incorporating antimicrobials such as benzoyl peroxide so that the composition may be useful as an acne medication, for example. In some embodiments, the compositions of the present invention may also be formulated with barrier compounds to form barrier creams and lotions.
Materials which may be added to provide barrier protection for use as skin barriers to protect against diaper rash include but are not limited to 0.1 to 60% aldioxa, allantoin, aluminum acetate, aluminum hydroxide, bismuth subnitrate, boric acid, calamine, cellulose (microporous), cholecalciferol, cocoa butter, cod liver oil (in combination), colloidal oatmeal, cysteine hydrochloride, dexpanthenol, dimethicone, glycerin kaolin, lanolin (in combination), live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsam oil, pertrolatum, protein hydrolysate (1-leucine, 1-isoleucine, 1-methionine, 1-phenylalanine, and 1-tyrosine), racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate and zinc oxide.
In some embodiments, the compositions of the invention may comprise one or more formulations containing antifungal agents for the treatment of fimgal infections of the skin such as athlete's foot and the like.
While some embodiments will include one additional secondary antimicrobial agent, other embodiments of the invention can include two or more additional secondary antimicrobials. While the foregoing secondary antimicrobials can be added to the compositions individually or singly, combinations of two or more of the foregoing secondary antimicrobials are also contemplated within the scope of the invention.
In some embodiments, the compositions of the present invention may be formulated into non-aerosol products that can be dispensed from a reservoir using a hand-pump, for example, to dispense an amount of the composition whenever the hand pump is actuated.
The amount of the composition dispensed by the pump may or may not be metered so that the amount of composition dispensed may or may not be consistent. Moreover, the compositions of the invention are not limited to being dispensed from only one type of dispenser or through only one type of hand pump.
In some embodiments, the compositions are capable of being formulated into an aerosol foam or a mousse by addition of propellant to the composition. Suitable propellants can be chosen from chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorinated alkanes, and lower alkanes (Cl- C5) as well as nitrous oxide dimethyl ether and other solvent-soluble propellants. Suitable lower alkanes include propane, butane, and isobutane, for example. In some embodiments, the propellant can comprise a 70/30 mixture of propane/isobutane. In order to produce an aerosol composition the composition is first formulated and charged into an appropriate pressure rated container. A suitable propellant may then be added to the composition under pressure at approximately 2-30% preferably 3-20% by volume. The propellant may form a separate layer on the composition or the propellant may be emulsified or miscible in the composition.
The compositions of the invention can be used in any of a variety of applications including use as a sanitizer for application to a surface. The compositions of the invention are suitable for use on mammalian skin including the human hands. In some embodiments, the compositions may be used as a pre-surgical hand scrub. In non-aerosol formulations of the invention, the compositions may be contained in a non-aerosol dispenser equipped with a conventional hand pump, and the composition may be pumped onto the hands or other areas of the body. The pumping action required to dispense the compositions will create a discrete volume of a dispensed composition in the form of a stable foam.
Likewise, in embodiments comprising an aerosol, the aerosol formulation may be dispensed from a pressurized container in a discrete volume of foamed composition. After dispensing, the foam may be spread upon the surface of the skin to sanitize the skin, the hands or the like. While some residue may remain on the skin following evaporation of the alcohol component, the residue can comprise emollients Or the like to provide a desired cosmetic effect. Consequently, the compositions of the invention provide a means for sanitizing skin in the form of a foamable composition which does not need to be rinsed from the skin following application of the foam to the area in need of sanitization.
Alternatively, undesired residue remaining on the surface can be rinsed off with water, for example.
From the foregoing, it will be appreciated that the present invention also encompasses systems for dispensing the compositions comprising a reservoir and an amount of composition retained therein, and means for dispensing the composition from the reservoir.
The compositions of the present invention may be prepared by a variety of techniques and the ingredients may be added to one another in any order of addition. To ensure a composition of maximum stability, the components may be subjected to high shear (e.g.
homogenized) for a limited time period.
EXAMPLES
The following non-limiting Examples are provided to illustrate features of the invention.
are not intended to limit the scope of the invention. All percent amounts are weight/weight percent (wt/wt%) unless otherwise noted.
Preparation of Compositions The compositions in the Examples were prepared in 60 gram samples by combining all components in a glass jar and rolling the jar overnight, on a mechanical roller. The foam builder was introduced to the mixture by first preparing a premix of the foam builder at ranges from 0.5% to 8.0% wt/wt, prepared in water/alcohol. The appropriate weight of premix was then added to the mixture containing the other components prior to the step of mixing by rolling overnight.
According to the Material Safety Data Sheets of certain dimethicone copolyol surfactants, the surfactants are known to contain significant quantities of PEO/PPO block copolymers of the type described herein as builders. These copolymers may be byproducts of the manufacturing process for the copolyol surfactants. The surfactants and builders used in the compositions of the Examples are listed in Tables 1 and 2.
Table 1 ¨ Surfactants Trade Name INCI Name Surfactant Mfr. Mfr.
Location PEG/PPG-4/12 Goldschmidt Abil B 8852 Hopewell,VA
Dimethicone Chemical Corp.
PEG/PPG-35/65 Goldschmidt Abil B 8873 Hopewell,VA
Dimethicone 7,000MW Chemical Corp.
Dow 190 Fluidl PEG/PPG-18/18 Dow Corning Midland, MI
Dimethicone PEG-12 Dimethicone, Dow 193 Fluid2 Dow Corning Midland, MI
Hydroxyl terminated Hydroxyl capped Lambent Lambent MFF-164 Gurnee, IL
dimethicone copolyol Technologies Inc.
Lambent Lambent Quat AD Silicone Quaternary 1 Gurnee, IL
Technologies Inc.
Silicone Quaternary 2 Lambent Lambent Quat AM Gurnee, IL
(Myristyl) Technologies Inc.
Acrylic backbone polymer with Lambent Lambent Syngard 300 Gurnee, IL
dimethylsiloxane Technologies Inc.
sidechains Dimethicone copolyol Lambent Lambent Wax WS-L Gurnee, IL
Laurate Technologies Inc.
Silicone Copolyol Lambent Lambent Wax WS-p Gurnee, IL
Pelargonate Technologies Inc.
Dimethicone Copolyol PCI Pheonix Pecosil DCL Somerville, NJ
Lactate Chemical, Inc.
Sodium Dimethicone PCI Pheonix Pecosil DCT Copolyol Acetyl Somerville, NJ
Chemical, Inc.
Metlaytaurate Q2-5220 Resin Modifier3 PEG/PPG-17/18 Dow Corning Midland, MI
Dimethicone Silicone Copolyol Lambent Silwax WD-IS Gurnee, IL
Isostearate Technologies Inc.
PEG Dimethicone, Silwet 77 Methoxy Terminated, GE Silicones Midland, MI
Table 1 ¨ Surfactants Trade Name INCI Name Surfactant Mfr. Mfr. Location EO/PO, Methoxy Silwet L-7001 GE Silicones Wilton, CT
terminated 20,000MW
Silwet L-7200 Dimethicone Copolyol GE Silicones Midland, MI
PPO Dimethicone, Silwet L-7500 Butoxy Terminated, GE Silicones Midland, MI
3,000MW
PEG Dimethicone, Silwet L-7602 Methoxy Terminated, GE Silicones Wilton, CT
PEG Dimethicone, Silwet L-7604 Hydroxy Terminated, GE Silicones Midland, MI
PEG Dimethicone, Silwet L-7605 Methoxy Terminated, GE Silicones Wilton, CT
PEG Dimethicone, Silwet L-7614 Hydroxy Terminated, GE Silicones Wilton, CT
3MTm Silicones "Plus"
Polymer VS80 Polysilicone-8 3M Company St. Paul, MN
1. Dow 190 surfactant includes poly(ethylene oxide, propylene oxide) monoallyl ether acetate and polyether polyol acetate.
2. Dow 193 surfactant includes polyethylene oxide monoallyl ether.
3. Q2-5220 Resin Modifier includes poly(ethylene oxide, propylene oxide) monoallyl ether acetate; polyethylene glycol monoallyl ether acetate; and polyether polyol acetate.
Table 2 ¨ Foam Builders Trade Name Description Supplier / Mfr. Mfr.
Location Aqualon EC K100 Ethylcellulose Hercules Wilmington, DE
PEG-150 Pentaerythrityl Crothix Liquid tetrastearate (and) PEG-6 Croda Parsippany, NJ
Capric/Caprylic glycerides Economy Ecopol 120-S Hydroxypropyl Guar Polymers and Houston, TX
Chemicals Ganex Butylated Polyvinyl ISP
Wayne, NJ
P-904LC Pyrrolidone Technologies Cetyl Wilmington, Natrosol Plus Hercules hydroxyethylcellulose DE
Table 2¨ Foam Builders Trade Name Description Supplier / Mfr. Mfr.
Location International Plasdone PVP K-120 Polyvinyl Pyrrolidone Specialty Wayne, NJ
Products Pluronic Ethylene Oxide/Propylene Florham Park, BASF
F-108 Oxide Block Copolymer NJ
Pluronic Ethylene Oxide/Propylene Florham Park, BASF
F-127 Oxide Block Copolymer NJ
poly(ethylene oxide) Dow Chemical Polyox WSR N12K Midland, MI
Ave MW 1,000,000 Co.
poly(ethylene oxide) Dow Chemical Polyox WSR N6OK Midland, MI
Ave MW 2,000,000 Co.
poly(ethylene oxide) Dow Chemical Polyox WSR N-80 Midland, MI
Ave MW 200,000 Co.
poly(ethylene oxide) Dow Chemical Polyox WSR-301 Midland, MI
Ave MW 4,000,000 Co.
Polyvinyl Pyrrolidone (K Florham Park, value 90) NJ
Equipment Foam Pump ¨ A foam pump nozzle was used to generate foam from each composition.
The pump used was a pump dispenser, product Code F2, type F2-L11 255/150, available from Airspray International Inc. of North Pompano Beach, FL.
Foam Collection vial - Vials were used to collect foam from the pump dispenser while the foam height was being measured. The vials were made of glass and were of either 40 or 80 rnm height having a 25mm internal diameter and a 27mm outer diameter.
Test Methods Foam Height Test Procedure The Foam Pump was used to assess the foam forming property of the compositions. The pump was rinsed between samples with deionized water by pumping water through the pump until it came out clear. The pump dip tube was removed from the water and then pumped dry of residual water and then placed in the composition to be tested.
The pump was then pumped 3 times to prime the pump and then 3 more times to purge solution through the nozzle to ensure the system was ready. Finally, three pumps worth of foam were collected in a collection vial by pumping slowly at a speed of about 1 second for each pump. The vial containing the foam was placed on a flat surface, a timer was started and a small ruler with millimeter increments was used to measure the approximate height of the foam, ignoring the height of any remaining unfoamed composition. The time to measure the foam height usually took about 5 seconds. Any composition producing a foam which was not stable at least 5 seconds was considered unstable and rated 0 mm. The foam height was estimated to be the average height of the foam. A rating of 0 mm was given if the top of the solution was void of foam in any spot, usually the center. The foam height was recorded after 1, 3 and 5 minutes to determine the long term stability of the foam.
Foam Volume % Increase The percentage of foam volume increase over the solution volume was calculated by measuring the foam height in millimeters, subtracting 5mm from the foam height and dividing the result by 5 (the volume of the un-foamed pumped solution) and multiplying by 100%. Foam volume % increase measurements were made immediately following creation of the foam (e.g., after dispensing). Due to the difficulty in determining the exact foam surface, foam heights between 0-5 mm were reported as having a zero percent increase in foam volume.
Viscosity Viscosity in centipoise (cP) was measured at 23 C at ambient pressure using a Brookfield viscometer Model LVT equipped with a Brookfield LV spindle # 1 @ 60 rpm. All samples were allowed to equilibrate at 23 C for 24 hours prior to measurement.
The viscosity was taken at the lowest speed possible while staying within 10-100%
of the viscometer range and more preferably between 20-80% of the range. The viscosity was read after one minute of testing. In all cases the sample size and container geometry was chosen to ensure that there were no wall effects. By "wall effects" it is meant the viscosity value is not affected by the container and is essentially equivalent to the viscosity taken in an infinitely large container. For this reason lower viscosity samples required a larger sample size to accommodate the larger spindles.
Examples 1-13 Examples 1-13 were prepared using various amounts of the surfactant Dow 190;
plus a poly(ethylene oxide) (PEO) foam builder, available from Dow Chemical Company of Midland, MI, under the trade name POLY0X(TM) WSRN12K; distilled water, and an alcohol solvent. Foam height measurements according to the above test method were taken for each sample. The foam height measurements and formulations for each of the Examples are set forth in Table 3.
FoamInitial Foam Foam Foam Dow 190 Water SPA
Example Surf. 1 Amt. (Et0H/ rPA2 BuilderN Foam Height Height Height 12K Height 1 min. 3 min. 5 min.
Amt. % % IPA) Amt. % mm mm mm mm 1 1.00 0.060 43.94 55.00 - 32 2 1.00 0.060 38.94 60.00 - 32 3 1.00 0.060 35.17 63.77 - 35 4 1.00 0.060 28.94 70.00 - 34 5 1.00 0.060 23.94 75.00 - 28 26 21 17 6 1.00 0.060 18.94 80.00 - 30 29 23 14 7 1.00 0.060 43.94 - 55.00 36 35 32 28 8 1.00 0.060 34.94 - 64.00 35 _ 33 9 0.50 0.060 35.44 64.00 25 23 20 14
10 1.00 0.060 23.94 - 75.00 17 5 1 0
11 1.00 0.060 18.94 80.00 - 35 32 25 16
12 1.00 0.060 8.94 90.00 - 27 23 14 8
13 1.00 0.060 34.94 0.00 64.003 26 25 21 14 1. SDA is Specially Denatured Alcohol (SDA-3-C): a mixture of 100 parts CJSP
200 proof Ethanol plus 5 parts isopropyl alcohol (IPA).
2. IPA is isopropyl alcohol, reagent grade.
3. n-propanol (reagent grade) was used instead of isopropyl alcohol.
Examples 14-32 Examples 14-32 were all prepared with the same alcohol solvent, foam builder, surfactant and water content. The only variation in Examples 14-32 was the type of surfactant used.
The alcohol solvent was SDA-3-C and was present at 64.00%; the foam builder was PEO
N12K (listed above) and was present at 0.06 %; the water content was 25.50%
and the amount of surfactant was 2.50%. Foam height data and foam volume % increased data are reported in Table 4 for each of the compositions.
Table 4 Initial Foam Foam Foam Foam Foam Height Height Height Volume Height 1 min. 3 min. 5 min. %
Example Surfact.Trade Name mm mm mm Mm Increase
200 proof Ethanol plus 5 parts isopropyl alcohol (IPA).
2. IPA is isopropyl alcohol, reagent grade.
3. n-propanol (reagent grade) was used instead of isopropyl alcohol.
Examples 14-32 Examples 14-32 were all prepared with the same alcohol solvent, foam builder, surfactant and water content. The only variation in Examples 14-32 was the type of surfactant used.
The alcohol solvent was SDA-3-C and was present at 64.00%; the foam builder was PEO
N12K (listed above) and was present at 0.06 %; the water content was 25.50%
and the amount of surfactant was 2.50%. Foam height data and foam volume % increased data are reported in Table 4 for each of the compositions.
Table 4 Initial Foam Foam Foam Foam Foam Height Height Height Volume Height 1 min. 3 min. 5 min. %
Example Surfact.Trade Name mm mm mm Mm Increase
14 Dow 190 Fluid 45 42 28 12 800%
15 Dow 193 Fluid 30 0 0 0 500%
16 Abil B 8873 35 31 25 7 600%
17 Lambent MFF-164 34 32 28 22 580%
18 Lambent Quat AD 25 7 5 3 400%
19 Lambent Quat AM 30 0 0 0 500%
20 Lambent Wax WS-L 30 6 0 0 500%
21 Lambent Wax WS-p 35 26 0 0 600%
22 Pecosil DCL 34 20 0 0 580%
23 Pecosil DCT 15 0 0 0 200%
Q2-5220 Resin
Q2-5220 Resin
24 Modifier 30 27 23 14 500%
25 Silwax WD-IS 10 0 0 0 100%
26 Silwet 77 20 0 0 0 300%
27 Silwet L-7001 35 34 29 16 600%
28 Silwet L-7500 10 0 0 0 100%
29 Silwet L-7602 38 5 0 0 660%
30 Silwet L-7604 34 0 0 0 580%
31 Silwet L-7605 30 , 0 0 0 500%
32 Silwet L-7614 30 0 0 0 500%
Examples 33 ¨53 and Comparative Examples Cl ¨ C6 The Examples 33 ¨ 53 were all prepared with the same alcohol content of 65.00%
USP
200 proof ethanol. The amounts and type of surfactant, the amount of foam builder and the water content were varied. Comparative Examples Cl - C4 had no surfactant.
Examples C5 and C6 had no builder. Formulations, initial foam height measurements and foam volume % increases are reported in Table 5.
Table 5 Foam Initial Foam Foam Surf.Water Foam Builder Vise. Foam Height Height Example Surf. Type Amt. Amt. Vol. %
N12IC Cp Height 1 min. 3 min.
0/0 Increase Amt.% mm mm mm Silwet Cl 0.00 0.000 35.00 3.4 0 0 0 0%
Silwet
Examples 33 ¨53 and Comparative Examples Cl ¨ C6 The Examples 33 ¨ 53 were all prepared with the same alcohol content of 65.00%
USP
200 proof ethanol. The amounts and type of surfactant, the amount of foam builder and the water content were varied. Comparative Examples Cl - C4 had no surfactant.
Examples C5 and C6 had no builder. Formulations, initial foam height measurements and foam volume % increases are reported in Table 5.
Table 5 Foam Initial Foam Foam Surf.Water Foam Builder Vise. Foam Height Height Example Surf. Type Amt. Amt. Vol. %
N12IC Cp Height 1 min. 3 min.
0/0 Increase Amt.% mm mm mm Silwet Cl 0.00 0.000 35.00 3.4 0 0 0 0%
Silwet
33 0.10 0.000 34.90 3.1 5 0 0 0%
Silwet
Silwet
34 1.00 0.000 34.00 3.5 10 5 1 100%
Silwet C2 0.00 0.060 34.94 3.8 0 0 0 0%
Silwet
Silwet C2 0.00 0.060 34.94 3.8 0 0 0 0%
Silwet
35 0.10 0.060 34.84 4.1 18 0 0 260%
Silwet
Silwet
36 1.00 0.060 33.94 4.0 21 3 0 320%
Silwet
Silwet
37 5.00 0.060 29.94 3.9 17 0 0 240%
Silwet C3 0.00 0.200 34.80 5.6 0 0 0 0%
Silwet
Silwet C3 0.00 0.200 34.80 5.6 0 0 0 0%
Silwet
38 0.10 0.200 34.70 5.5 18 0 0 260%
Silwet
Silwet
39 1.00 0.200 33.80 4.9 23 18 0 360%
Silwet C4 0.00 0.500 34.50 15.4 0 0 0 0%
Silwet
Silwet C4 0.00 0.500 34.50 15.4 0 0 0 0%
Silwet
40 0.10 0.500 34.40 16.5 16 0 0 220%
41 Dow 190 1.00 0.060 33.94 3.9 40 38 35 700%
42 Dow 190 1.00 0.000 34.00 1.5 15 9 6 200%
Lambent
Lambent
43 1.00 0.060 33.94 4.0 20 0 0 300%
AD
Lambent C5 1.00 0.000 34.00 3.1 0 0 0 0%
AD
Lambent
AD
Lambent C5 1.00 0.000 34.00 3.1 0 0 0 0%
AD
Lambent
44 1.00 0.060 33.94 4.1 34 30 8 580%
WS-P
Lambent
WS-P
Lambent
45 1.00 0.000 34.00 3.0 11 8 3 120%
WS-P
WS-P
46 MFF-164 1.00 0.060 33.94 3,0 35 34 32 600%
47 MFF-164 1.00 0.000 34.00 2.5 14 10 7 180%
Pecosil
Pecosil
48 1.00 0.060 33.94 3.5 10 0 0 100%
DCT
Pecosil C6 1.00 0.000 34.00 3.0 0 0 0 0%
DCT
Silwet
DCT
Pecosil C6 1.00 0.000 34.00 3.0 0 0 0 0%
DCT
Silwet
49 1.00 0.500 33.50 16.0 17 13 0 240%
Lambent
Lambent
50 Syngard 1.00 0.060 34.94 ntl 33 32 30 560%
Abil B
Abil B
51 1.00 0.060 34.94 nt 34 34 20 580%
Silwet L-
Silwet L-
52 1,00 0.060 34.94 nt 37 39 32 640%
53 3M VS80 1.00 0.060 34.94 nt 26 18 14 420%
1. "nt" - not tested.
Examples 54 - 64 Examples 54 - 64 were all prepared with the same alcohol content of 65.00% USP
proof ethanol and the same surfactant content of 1.00% Q2-5220 Resin Modifier.
The amounts and the type of foam builder were varied as was the water content.
Composition, foam height and foam volume % increase are reported in Table 6.
Table 6 Initial Foam Foam Foam 1, Foam Foam Water Visc. Foam Height Height Height v"laill4 Example Builder Builder Amt.
Type Amt.% % m Cu Height 1 i 3 min. 5 min.
""
Increase mm mm mm Mm
1. "nt" - not tested.
Examples 54 - 64 Examples 54 - 64 were all prepared with the same alcohol content of 65.00% USP
proof ethanol and the same surfactant content of 1.00% Q2-5220 Resin Modifier.
The amounts and the type of foam builder were varied as was the water content.
Composition, foam height and foam volume % increase are reported in Table 6.
Table 6 Initial Foam Foam Foam 1, Foam Foam Water Visc. Foam Height Height Height v"laill4 Example Builder Builder Amt.
Type Amt.% % m Cu Height 1 i 3 min. 5 min.
""
Increase mm mm mm Mm
54 None 0.000 34.00 ntl 10 9 7 6 100%
55 Crothix 0.080 33.92 nt 12 10 7 7 140%
56 Crothix 0.300 33.70 4.9 12 9 8 6 140%
Ganex
Ganex
57 0.080 33.92 nt 11 9 8 8 120%
Ganex
Ganex
58 0.300 33.70 7.4 10 8 8 7 100%
Pluronic
Pluronic
59 0.080 33.92 nt 10 7 6 6 100%
Pluronic
Pluronic
60 0.300 33.70 3.1 10 9 7 7 100%
Pluronic
Pluronic
61 0.080 33.92 nt 11 9 7 6 120%
Pluronic
Pluronic
62 0.300 33.70 8.6 13 10 9 9 160%
63 PVP K-90 0.080 33.92 nt 13 10 9 7 160%
64 PVP K-90 0.300 33.70 4.3 9 9 6 6 80%
1. "nt" - not tested.
Examples 65 - 73 Examples 65 - 73 were all prepared with the same surfactant content of 1.00%, Dow 190.
The amounts of foam builder, water content and LISP 200 proof ethanol were all varied.
Additionally the type of foam builder was also varied. Composition, foam height and foam volume % increase are reported in Table 7.
Table 7 Initial Foam Foam Foam Foam Foam Water Et0H Foam Foam Height Height Height v Example Builder Builder Amt. Amt.
Height 1 min. 3 min. 5 min. "
Type Amt.% % %
Increase mm mm mm Mm
1. "nt" - not tested.
Examples 65 - 73 Examples 65 - 73 were all prepared with the same surfactant content of 1.00%, Dow 190.
The amounts of foam builder, water content and LISP 200 proof ethanol were all varied.
Additionally the type of foam builder was also varied. Composition, foam height and foam volume % increase are reported in Table 7.
Table 7 Initial Foam Foam Foam Foam Foam Water Et0H Foam Foam Height Height Height v Example Builder Builder Amt. Amt.
Height 1 min. 3 min. 5 min. "
Type Amt.% % %
Increase mm mm mm Mm
65 None 0 34.00 65.00 15 13 11 9 200%
Natrosol
Natrosol
66 Plus 0.06 33.98 64.96 13 10 8 6 160%
Natrosol
Natrosol
67 Plus 0.35 33.88 64.77 6 6 4 4 20%
Avalon
Avalon
68 EC K100 0.06 33.98 64.96 15 11 10 8 200%
Aqualon
Aqualon
69 EC K100 0.35 33.88 64.77 13 10 8 8 160%
Ecopol
Ecopol
70 120-S 0.06 33.98 64.96 12 9 8 7 140%
Ecopol
Ecopol
71 120-5 0.35 33.88 64.77 17 15 14 11 240%
72 PVP K-120 0.06 33.98 64.96 14 11 9 8 180%
73 PVP K-120 0.35 33.88 64.77 9 7 6 6 80%
Examples 74 - 78 Examples 74¨ 78 were formulated using PEO builders of different molecular weights.
Dow 190 in an amount of 1,00% was used as the surfactant for all of the Examples 68-72.
Formulation information and foam height data are given in Table 7. Fluid at an amount of 1.00%.
Table 8 Initial Foam Foam Foam PEO Foam PEO Foam Foam Water Alcohol Foam Height Height Height Example Builder Builder Builder Amt. Solvent Type MW Amt.% % Amt. %1 Height 1 min. 3 min. 5 min.
mm mm mm mm
Examples 74 - 78 Examples 74¨ 78 were formulated using PEO builders of different molecular weights.
Dow 190 in an amount of 1,00% was used as the surfactant for all of the Examples 68-72.
Formulation information and foam height data are given in Table 7. Fluid at an amount of 1.00%.
Table 8 Initial Foam Foam Foam PEO Foam PEO Foam Foam Water Alcohol Foam Height Height Height Example Builder Builder Builder Amt. Solvent Type MW Amt.% % Amt. %1 Height 1 min. 3 min. 5 min.
mm mm mm mm
74 WSR-301 4,000,000 0.060 29.94 69.00 22 15 10 8
75 N6OK 2,000,000 0,060 29.94 69.00 28 24 20 14
76 N12K 1,000,000 0.060 29,94 69.00 26 24 20 16 WSR N-
77 200,000 0.060 34.94 64.00 14 13 11 9
78 none 0 0.0 35.00 64.00 9 9 8 1. The alcohol in Examples 68 - 70 was 190 proof USP ethanol. The alcohol in Examples 71 ¨ 72 was 10 SDA-3-C alcohol solvent.
Secondary Antimicrobials Table 9 list various additional (secondary to alcohol) antimicrobials that were added to the 15 formulations described in Examples 73-76.
Table 9 Abbreviated Name Description Supplier / Mfr. Mfr. Location Medichem, S. A, 20 % Chlorhexidine distributed by CHG Paramus, NJ
Gluconate solution George Uhe Company, Inc.
para-chloro-meta- Ferro PCMX Cleveland, OH
xylenol Corporation Triclosan IRGASAN DP 300 Ciba Greensboro, NC
Citric Acid Citric Acid MCB Reagents Rahway, NJ
GML Glycerol monolaurate Med-Chem Labs Galena, IL
Abbreviated Name Description Supplier / Mfr. Mfr. Location Sodium Capril SCL
Lactylate Rita Corp.
Woodstock, IL
Examples 79 - 82 Examples 79 - 82 were formulated with the same components except that different secondary antimicrobials were used, as shown in Table 10. Foam height and foam volume % increase data are also set forth in Table 10.
Table 10 Surf. Foam Anti-Initial Foam Water Alcohol Secondary Foam Dow Builder Micro.
Foam Height Example Amt. SDA-3-C Anti-Vol. %
190 WSR- Amt.
Height 5 min.
% Amt. % Micro.
Increase Amt.% N12K % mm mm
Secondary Antimicrobials Table 9 list various additional (secondary to alcohol) antimicrobials that were added to the 15 formulations described in Examples 73-76.
Table 9 Abbreviated Name Description Supplier / Mfr. Mfr. Location Medichem, S. A, 20 % Chlorhexidine distributed by CHG Paramus, NJ
Gluconate solution George Uhe Company, Inc.
para-chloro-meta- Ferro PCMX Cleveland, OH
xylenol Corporation Triclosan IRGASAN DP 300 Ciba Greensboro, NC
Citric Acid Citric Acid MCB Reagents Rahway, NJ
GML Glycerol monolaurate Med-Chem Labs Galena, IL
Abbreviated Name Description Supplier / Mfr. Mfr. Location Sodium Capril SCL
Lactylate Rita Corp.
Woodstock, IL
Examples 79 - 82 Examples 79 - 82 were formulated with the same components except that different secondary antimicrobials were used, as shown in Table 10. Foam height and foam volume % increase data are also set forth in Table 10.
Table 10 Surf. Foam Anti-Initial Foam Water Alcohol Secondary Foam Dow Builder Micro.
Foam Height Example Amt. SDA-3-C Anti-Vol. %
190 WSR- Amt.
Height 5 min.
% Amt. % Micro.
Increase Amt.% N12K % mm mm
79 1.00 0.060 34.17 63.77 CHG 1.00 35 15 600%
80 1.00 0.060 34.17 63.77 PCMX 1.00 40 15 700%
81 1.00 0.060 34.17 63.77 Triclosan 1.00 36 12 620%
GML+CA
GML+CA
82 1.00 0.060 31.97 63.77 +SCL1 1.00 26 2 420%
1. Glycerol monolaurate at 1.00% 2.00% citric acid + 0.1% sodium caprillactylate Examples 83 - 107 Examples 83 - 107 were prepared to have the same alcohol content of 69.00%of proof ethanol. The Dow 190 surfactant and WSR-301 foam builder were used in various amounts as described in Table 11. Additionally, one or more emollient was added to each of the formulations. Formulations, initial foam height measurements and foam volume %
increase are reported in Table 11.
Table 11 Surf. Foam Initial Foam Foam Water Foam Dow Builderm33 Foam Height Height Vol.
Example Amt. Ml' M22 A) 190 WSR301 Height 1 min. 3 min.
Increase Amt.% Amt.% mm mm mm
1. Glycerol monolaurate at 1.00% 2.00% citric acid + 0.1% sodium caprillactylate Examples 83 - 107 Examples 83 - 107 were prepared to have the same alcohol content of 69.00%of proof ethanol. The Dow 190 surfactant and WSR-301 foam builder were used in various amounts as described in Table 11. Additionally, one or more emollient was added to each of the formulations. Formulations, initial foam height measurements and foam volume %
increase are reported in Table 11.
Table 11 Surf. Foam Initial Foam Foam Water Foam Dow Builderm33 Foam Height Height Vol.
Example Amt. Ml' M22 A) 190 WSR301 Height 1 min. 3 min.
Increase Amt.% Amt.% mm mm mm
83 1.00 0.06 28.94 1.00 0.00 0.00 24 18 14 380%
84 3.00 0.01 26.50 0.50 0.00 1.00 15 12 10 200%
85 2.00 0.01 26.00 1.00 1.00 1.00 17 14 10 240%
86 1.00 0.06 27.94 1.00 1.00 0.00 20 15 10 300%
87 3.00 0.06 26.00 0.00 1.44 0.50 29 25 22 480%
88 1.49 0.04 26.49 0.50 2.00 0.50 30 28 26 500%
89 3.00 0.04 26.00 0,00 0.97 1.00 34 31 24 580%
90 1.00 0.01 27.99 0.00 1.00 1.00 12 9 8 140%
91 1.00 0.01 27.99 1.00 0.00 1.00 14 9 8 180%
92 1.00 0.01 29.00 0.50 0.50 0.00 15 10 8 200%
93 3.00 0.06 26.00 1.00 0.94 0.00 25 20 18 400%
94 1.94 0.06 26.00 1.00 2.00 0.00 30 28 23 500%
95 1.00 0.06 28.94 0.00 0.00 1.00 27 22 16 440%
96 1.00 0.01 26.99 1.00 2.00 0.00 15 11 9 200%
97 1.50 0.01 29.00 0.00 0.00 0.50 15 10 10 200%
98 3.00 0.01 26.00 0.00 1.99 0.00 15 13 9 200%
99 2.97 0.06 26.00 1.00 0.00 0.97 25 23 18 400%
100 3.00 0.01 26.00 0.00 1.99 0.00 16 14 12 220%
101 2,00 0,06 27.94 0.00 0.00 1.00 30 22 17 500%
102 1.91 0.06 27.10 0.51 0.91 0.51 36 31 25 620%
103 1.00 0.01 26.99 0,00 2.00 1.00 14 10 7 180%
104 1.00 0.06 27.94 0.00 2.00 0.00 30 25 21 500%
105 3.00 0.01 26.99 1.00 0.00 0.00 15 12 8 200%
106 1.00 0.06 26.00 0.97 1.97 1.00 31 30 25 520%
107 2,00 0.06 27.94 1.00 0.00 0.00 31 28 20 520%
1. M1 was Myristyl Alcohol, available from Sasol North America, Westlake, LA.
2. M2 was G-18-0, glycereth 18 ethylhexanoate, available from Global 7, Franklin, NJ.
3. M3 was Glycerol, available from from Dow Chemical, Midland MI.
Examples 108 ¨ 113 Example 108 - 113 were prepared with the same alcohol content of 63.77 % SDA-3-C; the same amount of surfactant, Dow 190 at 1.00% and the same foam builder PEO, N12K , at an amount of 0.060%, The type and amount emollient was varied, as was the amount of water. Initial foam height measurements and foam volume % increase were taken and are reported in Table 12.
Table 12 Initial Foam Foam Foam Water.Foam Example Amt. Ml' m42, m53 Foam Heght Height Height Vol. %
Height 1 mm. 3 mm. 5 min.
Increase mm Mm mm mm
1. M1 was Myristyl Alcohol, available from Sasol North America, Westlake, LA.
2. M2 was G-18-0, glycereth 18 ethylhexanoate, available from Global 7, Franklin, NJ.
3. M3 was Glycerol, available from from Dow Chemical, Midland MI.
Examples 108 ¨ 113 Example 108 - 113 were prepared with the same alcohol content of 63.77 % SDA-3-C; the same amount of surfactant, Dow 190 at 1.00% and the same foam builder PEO, N12K , at an amount of 0.060%, The type and amount emollient was varied, as was the amount of water. Initial foam height measurements and foam volume % increase were taken and are reported in Table 12.
Table 12 Initial Foam Foam Foam Water.Foam Example Amt. Ml' m42, m53 Foam Heght Height Height Vol. %
Height 1 mm. 3 mm. 5 min.
Increase mm Mm mm mm
108 34.67 0.50 0.00 0.00 38 33 28 18 660%
109 34.17 1.00 0.00 0.00 37 34 23 13 640%
110 33.17 2.00 0.00 0.00 30 28 24 15 500%
111 32.17 3.00 0.00 0.00 30 24 24 15 500%
112 32.17 0.00 3.00 0.00 36 35 30 21 620%
113 32.17 0.00 0.00 3.00 35 34 26 15 600%
1. MI: Myristyl Alcohol, available from Sasol North America, Westlake, LA.
2. M4: Triethyl Citrate, NF available from Morflex Inc. of Greensboro, NC.
3. M5: Acetyl Triethyl Citrate, NF available from Morflex Inc. of Greensboro NC.
Table 13 Components for Comparative Examples C7 - C16 Trade/Abbrev. Name Description Supplier / Mfr. Mfr. Location Cocamido Propyl Monateric CAB-NPB Betaine Uniqema Wilmington, DE
BRIJ 52 PEO 2 cetyl alcohol Uniqema Wilmington, DE
Dimethicone Copolyol 19,000 MW 75/25 Silwet L-7200 EO/PO Ratio GE Silicones Midland, MI
Standamid KD Cocamide DEA Kraft Chemical Co. Melrose Park, IL
Super Solen PEG-75 PEG-75 Lanolin Croda Parsippany, NJ
Myristyl Alcohol Myristyl Alcohol Sasol Westlake, LA
PEO 4 Sorbitan mono Tween 61 stearate Uniqema Wilmington, DE
Table 13 Components for Comparative Examples C7 - C16 Trade/Abbrev. Name Description Supplier / Mfr. Mfr. Location Dermal DIA Diisopropyl Adipate Alzo International Sayreville, NJ
50:50 wt blend of Cetyl Cetearyl alcohol and Stearyl alcohol Croda Parsippany, NJ
PG Propylene Glycol Dow Chemical Midland, MI
FIydroxypropyl Methocel 40-100 methylcellulose Dow Chemical Midland, MI
Hydroxy Propyl Klucel Cellulose Hercules Wilmington, DE
cetearyl alcohol and Ritapro 300 ceteareth-20 Rita Corp. Woodstock, IL
Brij 72 Steareth-2 Uniqema Wilmington, DE
Brij 721 Steareth-21 Uniqema Wilmington, DE
Sigma Chemical Polysorbate 80 Polysorbate 80 Co. St. Louis, MO
Poly ethylene glycol PEG 400 400 MW Dow Chemical Midland, MI
Sodium Dodecyl Sodium Dodecyl benzene sulfonate benzene sulfonate Pfaltz and Bauer Waterbury, CT
Citric Acid Citric Acid MCB Reagents Rahway, NJ
Glycerol monolaurate Glycerol monolaurate Med-Chem Labs Galena, IL
Sodium Capril Sodium Capril Lactylate Lactylate Rita Corp. Woodstock, IL
Comparative Examples C7 ¨ C8 Comparative Examples C7 and C8 were tested for initial foam height after being prepared using the materials of Table 13 in the amounts listed in Tables 14A and 14B.
Table 14A
ClIG IJSP
Cetearyl Tween Initial Foam Example Soln. PG Ethanol Water 20%
alcohol 61 190 Proof Height mm C7 5.00 2.50 0.50 3.00 57.00 22.80 0 Table 14B
Myristyl Brij Initial Foam Example j 52 Glycerol IPA Water alcohol Height mm C8 3.00 0.80 2.50 60.00 25.40 0 Comparative Examples C9 - C11 Comparative Examples C9, C10 and C11 were prepared using the materials listed in Table 13 in the amounts listed in Table 15 and were tested using the standard Foam Height procedure described above. The Initial Foam Height for each Comparative Example C9 -C11, was 0 mm.
Table 15 USP
Cocamido Kraft Silwet L- Methocel PEG-75 Ethanol Ex. # Propyl Standamid Glycerin IPA
Water 7200 40-100 Lanolin 200 Betaine KD
Proof C9 0.20 10.00 7.00 1.00 3.00 0.20 - 60.00 17.97 C10 0.25 10.00 7.00 1.00 3.00 0.05 - 60.00 18.07 C11 0.25 10.00 7.00 1.00 3.00 0.05 70.0 - 8.07 Comparative Examples C12 - C14 Comparative Examples C12, C13 and C14 were prepared using various materials of Table 13 in the amounts listed in Table 16 and were tested using the standard Foam Height procedure described above.
Table 16 USP CHG Initial Ritapro Ethanol Foam Ex. # 300 Brij 72 Brij 721 Klucel 200 Water 20%
Height SoIn. I-Proof mm C12 2.50 1.88 0.625 0.20 60.00 14.62 0.060 C13 2.50 1.88 0.625 0.20 60.00 24.71 0.200 0 C14 2.50 1.88 0.625 0.20 60.00 32.23 0.200 Comparative Examples C15 ¨ C16 Comparative Examples C15 and C16 were prepared using various materials of Table 13 in the amounts listed in Table 17 and were tested using the standard Foam Height procedure described above.
Table 17 Sodium USP
Initial Dodecyl Polysorbate Propylene Ethanol Foam Ex. # Glycerol PEG 400 Water benzene 80 glycol 200 Height sulfonate Proof mm C15 3.00 1.00 1.50 0.50 0.00 55.00 37.25 0 C16 3.00 3.00 0.00 0.00 2.00 60.00 31.00 0 Various modifications and alterations of the present invention will be apparent to those skilled in the art. The Examples described in this application are illustrative of the possibilities of varying the type, quantity and ratio of composition as well as the methods for making formulations of the present invention.
1. MI: Myristyl Alcohol, available from Sasol North America, Westlake, LA.
2. M4: Triethyl Citrate, NF available from Morflex Inc. of Greensboro, NC.
3. M5: Acetyl Triethyl Citrate, NF available from Morflex Inc. of Greensboro NC.
Table 13 Components for Comparative Examples C7 - C16 Trade/Abbrev. Name Description Supplier / Mfr. Mfr. Location Cocamido Propyl Monateric CAB-NPB Betaine Uniqema Wilmington, DE
BRIJ 52 PEO 2 cetyl alcohol Uniqema Wilmington, DE
Dimethicone Copolyol 19,000 MW 75/25 Silwet L-7200 EO/PO Ratio GE Silicones Midland, MI
Standamid KD Cocamide DEA Kraft Chemical Co. Melrose Park, IL
Super Solen PEG-75 PEG-75 Lanolin Croda Parsippany, NJ
Myristyl Alcohol Myristyl Alcohol Sasol Westlake, LA
PEO 4 Sorbitan mono Tween 61 stearate Uniqema Wilmington, DE
Table 13 Components for Comparative Examples C7 - C16 Trade/Abbrev. Name Description Supplier / Mfr. Mfr. Location Dermal DIA Diisopropyl Adipate Alzo International Sayreville, NJ
50:50 wt blend of Cetyl Cetearyl alcohol and Stearyl alcohol Croda Parsippany, NJ
PG Propylene Glycol Dow Chemical Midland, MI
FIydroxypropyl Methocel 40-100 methylcellulose Dow Chemical Midland, MI
Hydroxy Propyl Klucel Cellulose Hercules Wilmington, DE
cetearyl alcohol and Ritapro 300 ceteareth-20 Rita Corp. Woodstock, IL
Brij 72 Steareth-2 Uniqema Wilmington, DE
Brij 721 Steareth-21 Uniqema Wilmington, DE
Sigma Chemical Polysorbate 80 Polysorbate 80 Co. St. Louis, MO
Poly ethylene glycol PEG 400 400 MW Dow Chemical Midland, MI
Sodium Dodecyl Sodium Dodecyl benzene sulfonate benzene sulfonate Pfaltz and Bauer Waterbury, CT
Citric Acid Citric Acid MCB Reagents Rahway, NJ
Glycerol monolaurate Glycerol monolaurate Med-Chem Labs Galena, IL
Sodium Capril Sodium Capril Lactylate Lactylate Rita Corp. Woodstock, IL
Comparative Examples C7 ¨ C8 Comparative Examples C7 and C8 were tested for initial foam height after being prepared using the materials of Table 13 in the amounts listed in Tables 14A and 14B.
Table 14A
ClIG IJSP
Cetearyl Tween Initial Foam Example Soln. PG Ethanol Water 20%
alcohol 61 190 Proof Height mm C7 5.00 2.50 0.50 3.00 57.00 22.80 0 Table 14B
Myristyl Brij Initial Foam Example j 52 Glycerol IPA Water alcohol Height mm C8 3.00 0.80 2.50 60.00 25.40 0 Comparative Examples C9 - C11 Comparative Examples C9, C10 and C11 were prepared using the materials listed in Table 13 in the amounts listed in Table 15 and were tested using the standard Foam Height procedure described above. The Initial Foam Height for each Comparative Example C9 -C11, was 0 mm.
Table 15 USP
Cocamido Kraft Silwet L- Methocel PEG-75 Ethanol Ex. # Propyl Standamid Glycerin IPA
Water 7200 40-100 Lanolin 200 Betaine KD
Proof C9 0.20 10.00 7.00 1.00 3.00 0.20 - 60.00 17.97 C10 0.25 10.00 7.00 1.00 3.00 0.05 - 60.00 18.07 C11 0.25 10.00 7.00 1.00 3.00 0.05 70.0 - 8.07 Comparative Examples C12 - C14 Comparative Examples C12, C13 and C14 were prepared using various materials of Table 13 in the amounts listed in Table 16 and were tested using the standard Foam Height procedure described above.
Table 16 USP CHG Initial Ritapro Ethanol Foam Ex. # 300 Brij 72 Brij 721 Klucel 200 Water 20%
Height SoIn. I-Proof mm C12 2.50 1.88 0.625 0.20 60.00 14.62 0.060 C13 2.50 1.88 0.625 0.20 60.00 24.71 0.200 0 C14 2.50 1.88 0.625 0.20 60.00 32.23 0.200 Comparative Examples C15 ¨ C16 Comparative Examples C15 and C16 were prepared using various materials of Table 13 in the amounts listed in Table 17 and were tested using the standard Foam Height procedure described above.
Table 17 Sodium USP
Initial Dodecyl Polysorbate Propylene Ethanol Foam Ex. # Glycerol PEG 400 Water benzene 80 glycol 200 Height sulfonate Proof mm C15 3.00 1.00 1.50 0.50 0.00 55.00 37.25 0 C16 3.00 3.00 0.00 0.00 2.00 60.00 31.00 0 Various modifications and alterations of the present invention will be apparent to those skilled in the art. The Examples described in this application are illustrative of the possibilities of varying the type, quantity and ratio of composition as well as the methods for making formulations of the present invention.
Claims (26)
1. A non-aerosol foamable composition, comprising:
(A) monohydric alcohol present in the composition at a concentration from about 35% to about 99.5% by weight;
(B) a dimethicone surfactant;
wherein the dimethicone surfactant is selected from the group consisting of hydroxy-terminated dimethicone copolyol, hydroxyl-capped dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, silicone copolyol pelargonate, Silicone Quaternary 1, Silicone Quaternary 2 (Myristyl), sodium dimethicone copolyol acetyl methyltaurate, dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyol laurate, dimethicone copolyolamine, dimethicone copolyol benzoate, dimethicone copolyol phthalate, dimethicone copolyol undecylenate, dimethicone copolyol crosspolymer, dimethicone copolyol lactate, dimethicone propyl pg-betaine, polysilicone-10, bis-hydroxyethoxypropyl dimethicone, disodium copolyol dimethicone sulfosuccinate, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, sodium carboxydecyl copolyol dimethicone; and combinations of two or more of the foregoing; and (C) a polymeric foam builder present in an amount sufficient to provide a stable foam formed from the composition, wherein a stable foam maintains a measurable height for at least 5 seconds following creation of the foam;
wherein the polymeric foam builder is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cetyl hydroxyethyl cellulose, ethylhydroxy ethyl cellulose, hydroxypropyl guar, polyglycerol, polyoxamer having a molecular weight of at least 100,000, polyoxamine, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-9, polyquaternium-11 to polyquaternium-47, polyvinyl methyl ether, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing;
wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 50 cps at 23°C.
(A) monohydric alcohol present in the composition at a concentration from about 35% to about 99.5% by weight;
(B) a dimethicone surfactant;
wherein the dimethicone surfactant is selected from the group consisting of hydroxy-terminated dimethicone copolyol, hydroxyl-capped dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, silicone copolyol pelargonate, Silicone Quaternary 1, Silicone Quaternary 2 (Myristyl), sodium dimethicone copolyol acetyl methyltaurate, dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyol laurate, dimethicone copolyolamine, dimethicone copolyol benzoate, dimethicone copolyol phthalate, dimethicone copolyol undecylenate, dimethicone copolyol crosspolymer, dimethicone copolyol lactate, dimethicone propyl pg-betaine, polysilicone-10, bis-hydroxyethoxypropyl dimethicone, disodium copolyol dimethicone sulfosuccinate, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, sodium carboxydecyl copolyol dimethicone; and combinations of two or more of the foregoing; and (C) a polymeric foam builder present in an amount sufficient to provide a stable foam formed from the composition, wherein a stable foam maintains a measurable height for at least 5 seconds following creation of the foam;
wherein the polymeric foam builder is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cetyl hydroxyethyl cellulose, ethylhydroxy ethyl cellulose, hydroxypropyl guar, polyglycerol, polyoxamer having a molecular weight of at least 100,000, polyoxamine, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-9, polyquaternium-11 to polyquaternium-47, polyvinyl methyl ether, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing;
wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 50 cps at 23°C.
2. The composition of claim 1 which demonstrates a percentage foam volume increase of at least 100%.
3. The composition of claim 1 wherein the viscosity of the composition prior to foaming at 23°C is within the range from about 0.5 cps to about 50 cps.
4. The composition of claim 1 wherein the foamable composition in a pre-foamed state has a viscosity of no greater than about 20 cps at 23°C.
5. The composition of claim 4 wherein the viscosity of the composition prior to foaming at 23°C is within the range from about 0.5 cps to about 20 cps.
6. The composition of claim 1 wherein the foam is formed from the foamable composition without the use of a propellant when shaken or dispensed from a dispenser.
7. The composition of claim 1 wherein the foam builder is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl guar, ethylhydroxy ethyl cellulose, polyoxamer, polyacrylamide, polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylic acid, polyquaternium-2, polyquaternium-4, polyquaternium-11, polyquaternium-15, polyquaternium-16, polyquaternium-22, polyquaternium-24, polyquaternium-28, polyquaternium-44, polyquaternium-46, butylated polyvinyl pyrrolidone, polyvinyl pyrrolidone, crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units, and combinations of two or more of the foregoing.
8. The composition of claim 1 wherein the foam builder is a homopolymer or copolymer containing N-vinyl lactam monomeric units selected from the group consisting of N-vinyl-2-pyrrolidone, N-vinyl-2-valerolactam, N-vinyl-2-caprolactam, and mixtures of any of the foregoing, and optionally one or more comonomers selected from the group consisting of N,N-dimethylacrylamide, acrylic acid, methacrylic acid, hydroxyethylmethacrylate, acrylamide, 2-acrylamido-2-methyl- 1-propane sulfonic acid or its salt, vinyl acetate, and mixtures of any of the foregoing.
9. The composition of claim 1 wherein the foam builder is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 1,000,000 to 10,000,000, polyethylene-polypropylene copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose, and combinations of two or more of the foregoing.
10. The composition of claim 1 wherein the monohydric alcohol is selected from the group consisting of ethanol, propanol, butanol, and combinations of two or more of the foregoing.
11. The composition of claim 1 wherein the monohydric alcohol is present in the composition at a concentration from about 60% to about 80% by weight.
12. The composition of claim 1 wherein the surfactant is present in the composition at a concentration from about 0.1% to about 10% by weight.
13. The composition of claim 12 wherein the surfactant is present in the composition at a concentration from about 0.5% to about 5% by weight.
14. The composition of claim 1 wherein the foam builder is present in the composition at a concentration between about 0.001% and about 5% by weight.
15. The composition of claim 1 wherein the foam builder is present in the composition at a concentration less than or equal to about 0.5% by weight.
16. The composition of claim 15 wherein the foam builder is present in the composition at a concentration less than or equal to about 0.1% by weight.
17. The composition of claim 16 wherein the foam builder is present in the composition at a concentration of about 0.06% by weight.
18. The composition of claim 1 wherein the dimethicone surfactant is selected from hydroxy-terminated dimethicone copolyol, methoxy-terminated dimethicone copolyol, butoxy-terminated dimethicone copolyol, or combination of two or more of the foregoing.
19. The composition of claim 1 further comprising an emollient wherein the emollient is present in the composition at a concentration of about 30% by weight or less.
20. The composition of claim 1 further comprising an antimicrobial agent, present in the composition at a concentration up to about 10% by weight.
21. The composition of claim 1 further comprising one or more skin barrier materials in an amount from about 0.1% to 60% by weight.
22. The composition of claim 1 further comprising an antifungal agent.
23. The composition of claim 20 wherein the antimicrobial agent is selected from the group consisting of parachlorometaxylenol, triclosan, chlorhexidine and its salts, polyhexamethylene biguanide and its salts, iodine, idodophors, fatty acid monoesters, poly-n-vinyl pyrrolidone-iodophors, silver oxide, silver and its salts, peroxides, antibiotics, and combinations of two or more of the foregoing.
24. The composition of claim 23 wherein the antimicrobial agent is benzoyl peroxide.
25. The composition of claim 21 wherein the barrier material is selected from the group consisting of aldioxa, allantoin, aluminum acetate, aluminum hydroxide, bismuth subnitrate, boric acid, calamine, cellulose, cholecalciferol, cocoa butter, cod liver oil, colloidal oatmeal, cysteine hydrochloride, dexpanthenol, dimethicone, glycerin kaolin, lanolin, live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsam oil, pertrolatum, protein hydrolysate, racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate, zinc oxide and combinations of two or more of the foregoing.
26. A system comprising:
a dispenser comprising a reservoir and a hand pump; and the foamable composition of claim 1 contained within the reservoir.
a dispenser comprising a reservoir and a hand pump; and the foamable composition of claim 1 contained within the reservoir.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/151,563 | 2005-06-13 | ||
US11/151,563 US7651990B2 (en) | 2005-06-13 | 2005-06-13 | Foamable alcohol compositions comprising alcohol and a silicone surfactant, systems and methods of use |
PCT/US2006/021904 WO2006138111A1 (en) | 2005-06-13 | 2006-06-06 | Foamable alcohol compositions, systems and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2610945A1 CA2610945A1 (en) | 2006-12-28 |
CA2610945C true CA2610945C (en) | 2016-06-28 |
Family
ID=37075262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2610945A Active CA2610945C (en) | 2005-06-13 | 2006-06-06 | Foamable alcohol compositions, systems and methods of use |
Country Status (12)
Country | Link |
---|---|
US (4) | US7651990B2 (en) |
EP (1) | EP1893167A1 (en) |
JP (1) | JP5266049B2 (en) |
KR (1) | KR101389199B1 (en) |
CN (1) | CN101198308B (en) |
AU (1) | AU2006259687B2 (en) |
BR (1) | BRPI0613333A2 (en) |
CA (1) | CA2610945C (en) |
MX (1) | MX2007015768A (en) |
NO (1) | NO20080261L (en) |
TW (1) | TW200710220A (en) |
WO (1) | WO2006138111A1 (en) |
Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6623744B2 (en) * | 1995-06-22 | 2003-09-23 | 3M Innovative Properties Company | Stable hydroalcoholic compositions |
CA2224798A1 (en) * | 1995-06-22 | 1997-01-09 | Matthew T. Scholz | Stable hydroalcoholic compositions |
US7566460B2 (en) * | 1995-06-22 | 2009-07-28 | 3M Innovative Properties Company | Stable hydroalcoholic compositions |
US7747507B2 (en) | 1996-05-23 | 2010-06-29 | Ticketmaster L.L.C. | Computer controlled auction system |
US6582711B1 (en) | 1997-01-09 | 2003-06-24 | 3M Innovative Properties Company | Hydroalcoholic compositions thickened using polymers |
US9477820B2 (en) | 2003-12-09 | 2016-10-25 | Live Nation Entertainment, Inc. | Systems and methods for using unique device identifiers to enhance security |
US10366373B1 (en) | 2002-12-09 | 2019-07-30 | Live Nation Entertainment, Incorporated | Apparatus for access control and processing |
US9740988B1 (en) | 2002-12-09 | 2017-08-22 | Live Nation Entertainment, Inc. | System and method for using unique device indentifiers to enhance security |
AU2004275900B2 (en) | 2003-09-29 | 2010-04-29 | Deb Ip Limited | High alcohol content gel-like and foaming compositions |
US8078483B1 (en) | 2003-12-16 | 2011-12-13 | Ticketmaster | Systems and methods for queuing access to network resources |
DE102004062775A1 (en) | 2004-12-21 | 2006-06-29 | Stockhausen Gmbh | Alcoholic pump foam |
US8263098B2 (en) | 2005-03-07 | 2012-09-11 | Deb Worldwide Healthcare Inc. | High alcohol content foaming compositions with silicone-based surfactants |
US20060204466A1 (en) * | 2005-03-08 | 2006-09-14 | Ecolab Inc. | Hydroalcoholic antimicrobial composition with skin health benefits |
DE602006010127D1 (en) * | 2005-03-18 | 2009-12-17 | Tokuyama Corp | Curable composition |
US9608929B2 (en) | 2005-03-22 | 2017-03-28 | Live Nation Entertainment, Inc. | System and method for dynamic queue management using queue protocols |
US7651990B2 (en) * | 2005-06-13 | 2010-01-26 | 3M Innovative Properties Company | Foamable alcohol compositions comprising alcohol and a silicone surfactant, systems and methods of use |
FR2894467B1 (en) * | 2005-12-08 | 2008-02-15 | Oreal | FOESENED COSMETIC COMPOSITION OF LOW DENSITY |
US20070148101A1 (en) * | 2005-12-28 | 2007-06-28 | Marcia Snyder | Foamable alcoholic composition |
WO2007092406A2 (en) | 2006-02-07 | 2007-08-16 | Ticketmaster | Methods and systems for reducing burst usage of a networked computer system |
US8450378B2 (en) * | 2006-02-09 | 2013-05-28 | Gojo Industries, Inc. | Antiviral method |
US20070185216A1 (en) * | 2006-02-09 | 2007-08-09 | Marcia Snyder | Antiviral method |
US8119115B2 (en) | 2006-02-09 | 2012-02-21 | Gojo Industries, Inc. | Antiviral method |
US9629361B2 (en) | 2006-02-09 | 2017-04-25 | Gojo Industries, Inc. | Composition and method for pre-surgical skin disinfection |
WO2007103441A2 (en) * | 2006-03-06 | 2007-09-13 | Borish Edward T | Antimicrobial esters |
US7723279B2 (en) * | 2006-08-23 | 2010-05-25 | The Clorox Company | Foamable compositions containing alcohol |
US20100189809A1 (en) * | 2006-08-23 | 2010-07-29 | The Clorox Company | Foamable Compositions Containing Alcohol |
MX2009003455A (en) * | 2006-10-02 | 2009-09-25 | Dow Global Technologies Inc | High alcohol-content foams. |
US8580860B2 (en) * | 2007-02-23 | 2013-11-12 | Gojo Industries, Inc. | Foamable alcoholic composition |
US8065773B2 (en) | 2007-04-02 | 2011-11-29 | Bard Access Systems, Inc. | Microbial scrub brush |
US8336152B2 (en) | 2007-04-02 | 2012-12-25 | C. R. Bard, Inc. | Insert for a microbial scrubbing device |
US9192449B2 (en) | 2007-04-02 | 2015-11-24 | C. R. Bard, Inc. | Medical component scrubbing device with detachable cap |
US8053399B2 (en) * | 2007-08-30 | 2011-11-08 | Kimberly-Clark Worldwide, Inc. | Foamable compositions |
EP2031048B2 (en) * | 2007-08-31 | 2019-05-01 | The Procter and Gamble Company | Liquid acidic hard surface cleaning composition |
US9807096B2 (en) | 2014-12-18 | 2017-10-31 | Live Nation Entertainment, Inc. | Controlled token distribution to protect against malicious data and resource access |
EP2039748A1 (en) * | 2007-09-17 | 2009-03-25 | The Procter and Gamble Company | Process of treating inclined hard surface |
EP2039747A1 (en) | 2007-09-17 | 2009-03-25 | The Procter and Gamble Company | Process for treating hard surface |
US9381150B2 (en) * | 2008-03-07 | 2016-07-05 | Kimberly-Clark Worldwide, Inc. | Alcohol antimicrobial skin sanitizing compositions including cationic compatible thickeners |
US8696820B2 (en) | 2008-03-31 | 2014-04-15 | Bard Access Systems, Inc. | Method of removing a biofilm from a surface |
US7842725B2 (en) | 2008-07-24 | 2010-11-30 | Ecolab USA, Inc. | Foaming alcohol compositions with selected dimethicone surfactants |
US8069523B2 (en) | 2008-10-02 | 2011-12-06 | Bard Access Systems, Inc. | Site scrub brush |
JP2010111609A (en) * | 2008-11-05 | 2010-05-20 | Kao Corp | Hand and finger-disinfecting agent composition |
US20100135949A1 (en) * | 2008-12-01 | 2010-06-03 | Becton, Dickinson And Company | Antimicrobial compositions |
CA2757080C (en) | 2009-04-01 | 2017-03-14 | C. R. Bard, Inc. | Microbial scrubbing device |
DE102010004950A1 (en) * | 2010-01-18 | 2011-07-21 | Remis Gesellschaft für Entwicklung und Vertrieb von technischen Elementen mbH, 50829 | Cooling shelf with door device |
CA2828086C (en) | 2010-03-10 | 2018-07-31 | Nuvo Research Inc. | Foamable formulation |
WO2011149645A1 (en) | 2010-05-28 | 2011-12-01 | Nuvo Research Inc. | Topical etoricoxib formulation |
CA2802686C (en) | 2010-06-15 | 2019-10-01 | Ticketmaster, Llc | Methods and systems for computer aided event and venue setup and modeling and interactive maps |
US10096161B2 (en) | 2010-06-15 | 2018-10-09 | Live Nation Entertainment, Inc. | Generating augmented reality images using sensor and location data |
US9781170B2 (en) | 2010-06-15 | 2017-10-03 | Live Nation Entertainment, Inc. | Establishing communication links using routing protocols |
US20120171301A1 (en) * | 2010-12-30 | 2012-07-05 | David William Koenig | Durable Antimicrobial Composition Including a Surfactant |
US20120171300A1 (en) * | 2010-12-30 | 2012-07-05 | David William Koenig | Durable Antimicrobial Composition Including a Surfactant |
US9949477B2 (en) | 2010-12-30 | 2018-04-24 | Kimberly-Clark Worldwide, Inc. | Durable antimicrobial composition |
US9161531B2 (en) * | 2011-02-23 | 2015-10-20 | Donald R. Korb | High alcohol content sanitizer |
CA2830406C (en) * | 2011-03-15 | 2019-02-12 | Thompson Cooper Laboratories, Llc | Compositions and methods for treatment of infections |
US9295251B1 (en) | 2011-04-08 | 2016-03-29 | Safehands Solutions, LLC | Synergistic antimicrobial compositions of PCMX and carboxylic acid and related methods |
US9089129B2 (en) * | 2011-10-07 | 2015-07-28 | American Sterilizer Company | Non-aerosol foaming alcohol hand sanitizer |
US8865195B2 (en) * | 2011-10-13 | 2014-10-21 | Kimberly-Clark Worldwide, Inc. | Foaming formulations and cleansing products including silicone polyesters |
US8304375B1 (en) | 2011-10-13 | 2012-11-06 | Kimberly-Clark Worldwide, Inc. | Foaming formulations including silicone polyesters |
CA2865119C (en) | 2012-02-24 | 2020-01-14 | Gojo Industries, Inc. | Antimicrobial and foamable alcoholic compositions |
AU2013240259B2 (en) * | 2012-03-30 | 2016-09-22 | Gojo Industries, Inc. | Antimicrobial alcohol foam compositions and methods of preparation |
US20130255061A1 (en) * | 2012-04-03 | 2013-10-03 | Becton, Dickinson And Company | Systems and methods for applying a novel antimicrobial coating material to a medical device |
US9352119B2 (en) | 2012-05-15 | 2016-05-31 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
GB201211702D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Sprayable aqueous alcoholic microbicidal compostions comprising zinc ions |
GB201211691D0 (en) | 2012-07-05 | 2012-08-15 | Reckitt Benckiser Llc | Sprayable aqueous alcoholic microbicidal compositions comprising zinc ions |
GB201211688D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Aqueous alcoholic microbicidal compositions comprising zinc ions |
GB201211701D0 (en) | 2012-07-02 | 2012-08-15 | Reckitt Benckiser Llc | Aqueous alcoholic microbicidal compositions comprising zinc ions |
US9579486B2 (en) | 2012-08-22 | 2017-02-28 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
WO2014083330A1 (en) | 2012-11-30 | 2014-06-05 | Reckitt & Colman (Overseas) Limited | Microbicidal personal care compositions comprising metal ions |
US9695323B2 (en) | 2013-02-13 | 2017-07-04 | Becton, Dickinson And Company | UV curable solventless antimicrobial compositions |
US9750928B2 (en) | 2013-02-13 | 2017-09-05 | Becton, Dickinson And Company | Blood control IV catheter with stationary septum activator |
FI128215B (en) * | 2013-05-28 | 2019-12-31 | Argenlab Global Ltd | Low alcohol content disinfection foams |
US9439841B2 (en) | 2013-06-06 | 2016-09-13 | Ecolab Usa Inc. | Alcohol based sanitizer with improved dermal compatibility and feel |
WO2015030768A1 (en) * | 2013-08-29 | 2015-03-05 | Colgate-Palmolive Company | Aqueous liquid compositions |
WO2015061552A1 (en) * | 2013-10-23 | 2015-04-30 | Gojo Industries, Inc. | Foamable alcoholic compositions containing branched foaming surfactants |
CA2940494C (en) | 2014-03-14 | 2022-11-08 | Gojo Industries, Inc. | Hand sanitizers with improved aesthetics and skin-conditioning to encourage compliance with hand hygiene guidelines |
US10376686B2 (en) | 2014-04-23 | 2019-08-13 | Becton, Dickinson And Company | Antimicrobial caps for medical connectors |
US9675793B2 (en) | 2014-04-23 | 2017-06-13 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
US9789279B2 (en) | 2014-04-23 | 2017-10-17 | Becton, Dickinson And Company | Antimicrobial obturator for use with vascular access devices |
US9970303B2 (en) | 2014-05-13 | 2018-05-15 | Entrotech, Inc. | Erosion protection sleeve |
US10232088B2 (en) | 2014-07-08 | 2019-03-19 | Becton, Dickinson And Company | Antimicrobial coating forming kink resistant feature on a vascular access device |
JP6706614B2 (en) * | 2014-07-09 | 2020-06-10 | 99 ホールディング エス・アー・エール・エル99 Holding S.A.R.L. | Bactericidal composition containing silver ions and a quaternary salt |
US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
WO2016085906A1 (en) * | 2014-11-25 | 2016-06-02 | Gojo Industries, Inc. | Foamable alcoholic sanitizing compositions with branched polyethoxylated dimethicone foaming surfactants and isopropanol |
CN104490630A (en) * | 2014-12-09 | 2015-04-08 | 南阳市汇博生物技术有限公司 | No-washing foam hand disinfection solution and preparation method thereof |
WO2016164316A1 (en) | 2015-04-06 | 2016-10-13 | 3M Innovative Properties Company | Removable film forming gel compositions and methods for their application |
US10813357B1 (en) | 2015-05-26 | 2020-10-27 | Gojo Industries, Inc. | Compositions and methods with efficacy against spores and other organisms |
JP6577322B2 (en) * | 2015-10-07 | 2019-09-18 | エア・ウォーター・ゾル株式会社 | Aerosol preparation containing ethanol |
US10493244B2 (en) | 2015-10-28 | 2019-12-03 | Becton, Dickinson And Company | Extension tubing strain relief |
AU2016354572B2 (en) | 2015-11-12 | 2020-08-27 | Gojo Industries, Inc. | Sequentially activated multi-diaphragm foam pump |
US10065199B2 (en) | 2015-11-13 | 2018-09-04 | Gojo Industries, Inc. | Foaming cartridge |
JP6834376B2 (en) * | 2015-11-17 | 2021-02-24 | 日油株式会社 | Surfactant composition |
US10080466B2 (en) | 2015-11-18 | 2018-09-25 | Gojo Industries, Inc. | Sequentially activated multi-diaphragm foam pumps, refill units and dispenser systems |
US10080467B2 (en) | 2015-11-20 | 2018-09-25 | Gojo Industries, Inc. | Foam dispensing systems, pumps and refill units having high air to liquid ratios |
US10080468B2 (en) | 2015-12-04 | 2018-09-25 | Gojo Industries, Inc. | Sequentially activated multi-diaphragm foam pumps, refill units and dispenser systems |
US10441115B2 (en) | 2016-02-11 | 2019-10-15 | Gojo Industries, Inc. | High quality non-aerosol hand sanitizing foam |
JP7114474B2 (en) * | 2016-02-11 | 2022-08-08 | ゴジョ・インダストリーズ・インコーポレイテッド | High quality non-aerosol hand sanitizing foam |
JP6164543B1 (en) * | 2016-02-17 | 2017-07-19 | 株式会社アウラ | Photosensitive hair dye |
US10143339B2 (en) | 2016-04-06 | 2018-12-04 | Gojo Industries, Inc. | Sequentially activated multi-diaphragm foam pumps, refill units and dispenser systems |
US10912426B2 (en) | 2016-04-06 | 2021-02-09 | Gojo Industries, Inc. | Sequentially activated multi-diaphragm foam pumps, refill units and dispenser systems |
BR112018071523B1 (en) | 2016-04-20 | 2022-11-01 | S.C. Johnson & Son, Inc | AQUEOUS ANTIMICROBIAL COMPOSITION |
USD815838S1 (en) | 2016-07-15 | 2018-04-24 | Colgate-Palmolive Company | Toothbrush |
US20190381208A1 (en) | 2016-10-13 | 2019-12-19 | 3M Innovative Properties Company | Removable Film Forming Gel Compositions Featuring Adhesion Promoters |
EP3606343A1 (en) | 2017-04-04 | 2020-02-12 | Gojo Industries Inc | Methods and compounds for increasing virucidal efficacy in hydroalcoholic systems |
CA3067855A1 (en) | 2017-06-28 | 2019-01-03 | Collidion, Inc. | Compositions, methods and uses for cleaning, disinfecting and/or sterilizing |
US20200231905A1 (en) * | 2017-09-04 | 2020-07-23 | Dow Global Technologies Llc | Powder laundry detergent formulation |
IL275980B2 (en) | 2018-01-14 | 2023-10-01 | Collidion Inc | Compositions, Kits, Methods and Uses for Cleaning, Disinfecting, Sterilizing and/or Treating |
DE102018200732A1 (en) * | 2018-01-17 | 2019-07-18 | B. Braun Melsungen Ag | Composition for the disinfection of skin and / or hands |
WO2019215679A1 (en) * | 2018-05-10 | 2019-11-14 | Protair-X Health Solutions, Inc. | Foam sanitizer composition |
CN109288822A (en) * | 2018-08-24 | 2019-02-01 | 杭州氢源素生物科技有限公司 | A kind of viral Special sterilizing liquid and preparation method thereof containing polyglycerol ester |
WO2020098899A1 (en) * | 2018-11-14 | 2020-05-22 | MEKHIMAR, Abdelrahman Amin Abdelgawwad | The preventive shoes |
KR102584365B1 (en) * | 2018-12-19 | 2023-10-04 | 니토 메딕 가부시키가이샤 | Foaming external composition |
CN109646712B (en) * | 2018-12-26 | 2021-08-20 | 北京安德普泰医疗科技有限公司 | Colloidal sulfur liquid dressing and preparation method thereof |
CN109371667B (en) * | 2018-12-27 | 2021-05-14 | 福建省健为医疗用品有限公司 | Scouring reagent and bleaching method for pure cotton non-woven fabric and pure cotton non-woven fabric |
AU2020225262A1 (en) * | 2019-02-21 | 2021-08-19 | Chemetall Gmbh | An anti-rust composition for metal surface and a method of anti-rust treatment on metal surface |
CN114206402A (en) | 2019-05-31 | 2022-03-18 | 金德瓦药物控释公司 | Removable film-forming gel compositions featuring adhesion promoters |
BR112023006148A2 (en) * | 2020-10-23 | 2023-05-09 | Chattem Inc | FOAMABLE COMPOSITION, ITS USE AND PROCESS FOR PREPARING IT |
WO2023152136A1 (en) * | 2022-02-14 | 2023-08-17 | Unilever Ip Holdings B.V. | A foaming acidic hard surface cleaning composition |
CN115414271B (en) * | 2022-08-09 | 2023-09-15 | 纳爱斯浙江科技有限公司 | Shower gel with good skin feel after use |
Family Cites Families (137)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2054989A (en) * | 1933-12-30 | 1936-09-22 | Us Ind Alcohol Co | Compositions for application to the human skin |
US3131153A (en) * | 1961-10-25 | 1964-04-28 | Allied Chem | Foam producing compositions |
US3131152A (en) * | 1960-06-13 | 1964-04-28 | Allied Chem | Foam producing formulations |
US3824303A (en) * | 1963-07-24 | 1974-07-16 | Yardley Of London Inc | Collapsible foam pre-electric shave lotion containing diester lubricants |
US3395214A (en) * | 1964-01-09 | 1968-07-30 | Scholl Mfg Co Inc | Antiperspirant composition providing a readily collapsible sprayable foam |
US3709437A (en) * | 1968-09-23 | 1973-01-09 | Hershel Earl Wright | Method and device for producing foam |
US3770648A (en) | 1971-07-12 | 1973-11-06 | Bristol Myers Co | Anhydrous aerosol foam |
GB1424002A (en) * | 1972-05-26 | 1976-02-04 | Unilever Ltd | Hair preparations |
US3962150A (en) * | 1974-04-10 | 1976-06-08 | Richardson-Merrell Inc. | Foam producing cleansing compositions |
US4018364A (en) * | 1975-04-03 | 1977-04-19 | Hershel Earl Wright | Foam dispensing device |
US4311695A (en) * | 1979-12-03 | 1982-01-19 | Dow Corning Corporation | Personal-care emulsions comprising a siloxane-oxyalkylene copolymer |
US4511486A (en) | 1981-11-02 | 1985-04-16 | Richardson-Vicks Inc. | Method of cleaning dentures using aerated foams |
US4440653A (en) * | 1982-03-08 | 1984-04-03 | Halliburton Company | Highly stable alcohol foams and methods of forming and using such foams |
US4478853A (en) * | 1982-05-17 | 1984-10-23 | S. C. Johnson & Son, Inc. | Skin conditioning composition |
US4454060A (en) * | 1983-06-09 | 1984-06-12 | Colgate-Palmolive Company | Liquid detergent composition with a cationic foam stabilizing copolymer containing pendant quaternary nitrogen groups and pendant hydrophobic groups |
US4559226A (en) | 1983-09-06 | 1985-12-17 | Bernel Chemical Company Inc. | Self-emulsifying alkoxylate esters |
EP0160051B1 (en) * | 1983-10-24 | 1992-01-08 | Lockley Services Pty. Ltd. | Foamable biocide composition |
AU560740B2 (en) * | 1984-01-09 | 1987-04-16 | Unilever Plc | Pharmaceutical emulsion comprising an organic lactate and silicone oil |
US4772592A (en) * | 1984-01-09 | 1988-09-20 | Lever Brothers Company | Skin treatment composition |
US4584189A (en) * | 1984-09-28 | 1986-04-22 | Hercules Incorporated | Bactericidal toothpastes |
US4567038A (en) * | 1985-03-06 | 1986-01-28 | Revlon, Inc. | Sunscreen composition for hair protection |
US4826828A (en) * | 1985-04-22 | 1989-05-02 | Avon Products, Inc. | Composition and method for reducing wrinkles |
US4683004A (en) | 1985-08-20 | 1987-07-28 | Union Carbide Corporation | Foamable compositions and processes for use thereof |
US5288486A (en) | 1985-10-28 | 1994-02-22 | Calgon Corporation | Alcohol-based antimicrobial compositions |
LU86429A1 (en) | 1986-05-16 | 1987-12-16 | Oreal | COSMETIC COMPOSITIONS CONTAINING A CATIONIC POLYMER AND AN ANIONIC POLYMER AS A THICKENING AGENT |
JPH0678217B2 (en) | 1986-09-18 | 1994-10-05 | 花王株式会社 | Emulsified hair cosmetics |
US4857302A (en) * | 1987-02-20 | 1989-08-15 | Decker Jr Donald F | Solubilized benzoyl peroxide and cosmetic solution including solubilized benzoyl peroxide |
US4906459A (en) * | 1987-10-23 | 1990-03-06 | The Procter & Gamble Company | Hair care compositions |
FR2623396B1 (en) * | 1987-11-25 | 1990-03-30 | Sanofi Sa | USE OF ADEMETIONINE AGAINST AGING SKIN |
US4897262A (en) * | 1988-03-22 | 1990-01-30 | Playtex Jhirmack, Inc. | Non-aerosol hair spray composition |
US5232691A (en) * | 1989-04-26 | 1993-08-03 | Lemole Gerald M | Protective gel composition |
US4956170A (en) * | 1989-06-28 | 1990-09-11 | S. C. Johnson & Son, Inc. | Skin moisturizing/conditioning antimicrobial alcoholic gels |
JP2741105B2 (en) * | 1989-07-28 | 1998-04-15 | 久光製薬株式会社 | Foam aerosol formulation |
US5100658A (en) * | 1989-08-07 | 1992-03-31 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
US5104646A (en) * | 1989-08-07 | 1992-04-14 | The Procter & Gamble Company | Vehicle systems for use in cosmetic compositions |
US5290555A (en) * | 1989-09-14 | 1994-03-01 | Revlon Consumer Products Corporation | Cosmetic compositions with structural color |
US4983377A (en) * | 1989-10-31 | 1991-01-08 | The Procter & Gamble Company | Silicone hairspray compositions |
FR2657617B1 (en) | 1990-01-31 | 1994-03-25 | Oreal | OIL-IN-WATER EMULSIONS BASED ON INSOLUBLE SILICONES AND AN EMULSIFYING AGENT OF THE CARBOXYLIC ACID POLYOXYALKYLENE ACID TYPE, AND THEIR APPLICATION IN COSMETICS AND DERMATOLOGY. |
FR2658076B1 (en) * | 1990-02-12 | 1992-06-12 | Sanofi Sa | COSMETIC COMPOSITION CONTAINING COPOLYMERS OF AMINO ACIDS, USEFUL AS A MOISTURIZING AGENT. |
US4986922A (en) * | 1990-04-04 | 1991-01-22 | Dow Corning Corporation | Softening compositions including quaternary ammonium functional siloxanes |
US5128123A (en) * | 1991-02-08 | 1992-07-07 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Clear cosmetic sticks |
US5167950A (en) | 1991-03-28 | 1992-12-01 | S. C. Johnson & Son | High alcohol content aerosol antimicrobial mousse |
US5284486A (en) * | 1991-06-11 | 1994-02-08 | Microvena Corporation | Self-centering mechanical medical device |
GB9113517D0 (en) * | 1991-06-21 | 1991-08-07 | Procter & Gamble | Cleansing products |
CA2074293C (en) * | 1991-07-25 | 2002-03-19 | John R. Horoschak | Water-based hair fixative composition |
WO1993003703A2 (en) | 1991-08-19 | 1993-03-04 | The Procter & Gamble Company | Hair spray compositions |
GB9118979D0 (en) * | 1991-09-04 | 1991-10-23 | Unilever Plc | Cosmetic composition |
US5494533A (en) * | 1991-12-12 | 1996-02-27 | Richardson-Vicks, Inc. | Method for personal cleansing |
EP0639068A1 (en) | 1992-05-05 | 1995-02-22 | The Procter & Gamble Company | Acne treating composition |
WO1993025179A1 (en) | 1992-06-10 | 1993-12-23 | Alberto-Culver Company | Emulsifier salt compositions for applying silicone oil to hair |
US5690921A (en) * | 1992-10-15 | 1997-11-25 | Wella Aktiengesellschaft | Hair fixing composition in the form of an aqueous solution, foam or gel |
JP3398171B2 (en) | 1993-03-15 | 2003-04-21 | 株式会社資生堂 | Oil-in-water emulsion composition |
US5635469A (en) * | 1993-06-10 | 1997-06-03 | The Procter & Gamble Company | Foaming cleansing products |
US5662893A (en) * | 1993-06-25 | 1997-09-02 | Eastman Chemical Company | Clear pump hair spray formulations containing a linear sulfopolyester in a hydroalcoholic liquid vehicle |
US5484597A (en) * | 1993-07-30 | 1996-01-16 | Chesebrough-Pond's Usa Co. | Clear hydroalcholic cosmetic microemulsions |
ATE193309T1 (en) * | 1993-08-23 | 2000-06-15 | Procter & Gamble | THERMOPLASTIC AND ELASTOMER SILICONE GRAFT COPOLYMERS AND THEIR USE IN HAIR AND SKIN CARE PRODUCTS |
ATE175108T1 (en) | 1993-08-27 | 1999-01-15 | Procter & Gamble | POLYSILOXANE GRAFTED ADHESIVE POLYMER AND CARE PRODUCTS CONTAINING DRYING AID AGENT |
US5547662A (en) * | 1993-08-27 | 1996-08-20 | Becton, Dickinson And Company | Preparation of a skin surface for a surgical procedure |
FR2709953B1 (en) * | 1993-09-14 | 1995-11-24 | Oreal | Cosmetic composition containing at least one nonionic surfactant of the alkylpolyglycoside and / or polyglycerolated type and at least one polydimethylsiloxane / polyoxalkylene block copolymer. |
IT1265001B1 (en) * | 1993-12-16 | 1996-10-17 | Zambon Spa | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING (S) -2- (4- ISOBUTYLPHENYL) PROPIONIC ACID |
US5549888A (en) * | 1994-01-31 | 1996-08-27 | Procter & Gamble | Aqueous topical anti-acne compositions of low pH |
FR2717075B1 (en) | 1994-03-14 | 1996-04-05 | Oreal | Aqueous organopolysiloxane makeup gel. |
US5665332A (en) * | 1994-03-28 | 1997-09-09 | Oralcare Systems, Inc. | System for delivering foams containing medicaments |
US6086856A (en) * | 1994-03-28 | 2000-07-11 | Oralcare Systems, Inc. | System for delivering foamed oral hygiene compositions |
CA2151774C (en) | 1994-06-27 | 1999-04-06 | Minh Quang Hoang | Skin disinfecting formulations |
US5776430A (en) * | 1994-11-01 | 1998-07-07 | Calgon Vestal, Inc. | Topical antimicrobial cleanser containing chlorhexidine gluconate and alcohol |
AU4264396A (en) * | 1994-11-25 | 1996-06-19 | Laboratoires De Biologie Vegetale Yves Rocher | Cosmetic or pharmaceutical compositions containing mangiferin or derivatives thereof |
CA2206315A1 (en) * | 1994-11-29 | 1996-06-06 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof |
FI98290C (en) * | 1995-02-08 | 1997-05-26 | Kvaerner Masa Yards Oy | Water equalization arrangement |
SE506265C2 (en) * | 1995-04-28 | 1997-11-24 | Akzo Nobel Nv | Aqueous composition containing an alkyl glycoside and its use as a wetting agent |
US6623744B2 (en) * | 1995-06-22 | 2003-09-23 | 3M Innovative Properties Company | Stable hydroalcoholic compositions |
EP2314272A1 (en) * | 1995-06-22 | 2011-04-27 | Minnesota Mining And Manufacturing Company | Stable hydroalcoholic compositions |
CA2224798A1 (en) * | 1995-06-22 | 1997-01-09 | Matthew T. Scholz | Stable hydroalcoholic compositions |
US7566460B2 (en) * | 1995-06-22 | 2009-07-28 | 3M Innovative Properties Company | Stable hydroalcoholic compositions |
US5612234A (en) * | 1995-10-04 | 1997-03-18 | Lg Electronics Inc. | Method for manufacturing a thin film transistor |
US5733535A (en) * | 1995-10-25 | 1998-03-31 | The Procter & Gamble Co. | Topical compositions containing N-acetylcysteine and odor masking materials |
CA2260126C (en) * | 1996-07-10 | 2007-04-17 | Calgon Vestal, Inc. | Triclosan skin wash with enhanced efficacy |
US5756077A (en) | 1996-09-13 | 1998-05-26 | Avlon Industries, Inc. | Hair protectant composition and process for preserving chemically processed hair during subsequent chemical processing |
US6019997A (en) * | 1997-01-09 | 2000-02-01 | Minnesota Mining And Manufacturing | Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents |
US6582711B1 (en) | 1997-01-09 | 2003-06-24 | 3M Innovative Properties Company | Hydroalcoholic compositions thickened using polymers |
US5908619A (en) * | 1997-01-09 | 1999-06-01 | Minnesota Mining And Manufacturing Company | Hydroalcoholic compositions thickened using surfactant/polymer complexes |
US6491840B1 (en) | 2000-02-14 | 2002-12-10 | The Procter & Gamble Company | Polymer compositions having specified PH for improved dispensing and improved stability of wrinkle reducing compositions and methods of use |
GB2327881A (en) * | 1997-08-06 | 1999-02-10 | Reckitt & Colman Inc | Control of dust particles |
US5972356A (en) * | 1997-11-05 | 1999-10-26 | The Procter & Gamble Company | Personal care compositions |
WO2000006100A1 (en) * | 1998-07-30 | 2000-02-10 | The Procter & Gamble Company | Hair care product providing shine |
US6333039B1 (en) | 1998-09-25 | 2001-12-25 | Gojo Industries, Inc. | Opaque skin sanitizing composition |
US6053369A (en) | 1998-09-28 | 2000-04-25 | Becton Dickinson And Company | Foam forming liquid dispensing device |
US6143704A (en) * | 1998-10-13 | 2000-11-07 | Lever Brothers Company, Division Of Conopco, Inc. | Soap bars with little or no synthetic surfactant comprising organic salts |
FR2786392B1 (en) | 1998-11-26 | 2006-08-25 | Oreal | HAIR COMPOSITION COMPRISING A POLYMER WITH PARTICULAR CHARACTERISTICS AND A NON-IONIC POLYMER |
US6262128B1 (en) * | 1998-12-16 | 2001-07-17 | 3M Innovative Properties Company | Aqueous foaming compositions, foam compositions, and preparation of foam compositions |
WO2000047183A1 (en) * | 1999-02-12 | 2000-08-17 | The Procter & Gamble Company | Skin sanitizing compositions |
US6423329B1 (en) * | 1999-02-12 | 2002-07-23 | The Procter & Gamble Company | Skin sanitizing compositions |
US6183766B1 (en) * | 1999-02-12 | 2001-02-06 | The Procter & Gamble Company | Skin sanitizing compositions |
US6395264B1 (en) * | 1999-05-07 | 2002-05-28 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Low VOC hair spray compositions having enhanced styling benefits |
US6514944B2 (en) * | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US20020160924A1 (en) * | 1999-06-15 | 2002-10-31 | The Procter & Gamble Company | Cleaning compositions |
US6524594B1 (en) * | 1999-06-23 | 2003-02-25 | Johnson & Johnson Consumer Companies, Inc. | Foaming oil gel compositions |
US6685952B1 (en) * | 1999-06-25 | 2004-02-03 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Personal care compositions and methods-high internal phase water-in-volatile silicone oil systems |
US6762158B2 (en) * | 1999-07-01 | 2004-07-13 | Johnson & Johnson Consumer Companies, Inc. | Personal care compositions comprising liquid ester mixtures |
AU2001234509A1 (en) * | 2000-01-20 | 2001-07-31 | The Procter And Gamble Company | Antimicrobial compositions |
DE10009252A1 (en) | 2000-03-01 | 2001-09-06 | Henkel Kgaa | Cleaning gels producing heat of hydration on mixing with water and especially for use on the skin, contain water-miscible hydroxy compounds, surfactants, salts of negative solution enthalpy and thickeners |
JP2004500422A (en) | 2000-04-17 | 2004-01-08 | ユニリーバー・ナームローゼ・ベンノートシヤープ | Substantially dry cleaning products with improved lathering and wet flexibility |
US6342470B1 (en) * | 2000-04-26 | 2002-01-29 | Unilever Home & Personal Care Usa | Bar comprising soap, fatty acid, polyalkylene glycol and protic acid salts in critical ratios and providing enhanced skin care benefits |
US6696053B1 (en) * | 2000-05-04 | 2004-02-24 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Leave-on or rinse-out hair care conditioner compositions containing silicone quaternary compounds and thickeners |
US7264678B2 (en) * | 2000-06-14 | 2007-09-04 | The Procter & Gamble Company | Process for cleaning a surface |
US6410005B1 (en) * | 2000-06-15 | 2002-06-25 | Pmd Holdings Corp. | Branched/block copolymers for treatment of keratinous substrates |
US7271137B2 (en) * | 2000-06-29 | 2007-09-18 | Sandia Corporation | Decontamination formulations for disinfection and sterilization |
US6537952B2 (en) * | 2000-08-31 | 2003-03-25 | Unilever Home And Personal Care, Usa Division Of Conopco, Inc. | Foaming anti-bacterial cleansing skin product with low water insoluble emollients and foam dispenser |
AU2002215331A1 (en) * | 2000-10-20 | 2002-05-06 | Dipak Narula | Sanitizing hand cleanser |
US6617294B2 (en) * | 2000-10-20 | 2003-09-09 | Vinod K. Narula | Waterless sanitizing hand cleanser |
US6524494B2 (en) * | 2001-02-02 | 2003-02-25 | Givaudan Sa | Compositions to enhance fabric freshness and appearance |
US6780825B2 (en) * | 2001-02-06 | 2004-08-24 | Playtex Products, Inc. | Cleansing compositions with milk protein and aromatherapy |
US20020151446A1 (en) * | 2001-02-06 | 2002-10-17 | Playtex Products, Inc. | Mild foaming cleanser composition |
US6730621B2 (en) * | 2001-05-14 | 2004-05-04 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Damp cleansing wipe |
US6383997B1 (en) * | 2001-07-02 | 2002-05-07 | Dragoco Gerberding & Co. Ag | High lathering antibacterial formulation |
FR2827515B1 (en) * | 2001-07-20 | 2005-06-03 | Oreal | FOAMING COMPOSITION BASED ON SILICA AND CATIONIC POLYMER |
US20050030917A1 (en) * | 2001-08-17 | 2005-02-10 | Amit Haller | Device, system, method and computer readable medium obtaining a network attribute, such as a DNS address, for a short distance wireless network |
DE10147186A1 (en) | 2001-09-25 | 2003-04-24 | Beiersdorf Ag | Synergistic antimicrobial composition, useful e.g. as cosmetic preservative and for treating skin disorders, comprises polyhexamethylene biguanide and distearyldimethylammonium chloride |
US6846846B2 (en) * | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
US20040001797A1 (en) * | 2002-06-21 | 2004-01-01 | Abel Saud | Antimicrobial compositions, products and methods employing same |
US6818603B2 (en) | 2002-08-14 | 2004-11-16 | Johnson & Johnson Consumer Companies, Inc. | Cleansing bar containing discrete elements |
US7666826B2 (en) * | 2002-11-27 | 2010-02-23 | Ecolab Inc. | Foam dispenser for use in foaming cleaning composition |
US20040191195A1 (en) * | 2003-03-28 | 2004-09-30 | Carol Collins | Method of promoting a nail composition |
CA2424003A1 (en) * | 2003-03-28 | 2004-09-28 | Austin & Repatriation Medical Centre | Anti-microbial topical composition comprising alcohol and chlorhexidine salt |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
US7186416B2 (en) | 2003-05-28 | 2007-03-06 | Stiefel Laboratories, Inc. | Foamable pharmaceutical compositions and methods for treating a disorder |
GB0318160D0 (en) | 2003-08-02 | 2003-09-03 | Ssl Int Plc | Parasiticidal composition |
AU2004275900B2 (en) * | 2003-09-29 | 2010-04-29 | Deb Ip Limited | High alcohol content gel-like and foaming compositions |
DE102004016683A1 (en) | 2004-04-05 | 2005-10-27 | Wella Ag | Permanently foamed composition |
DE102004046603A1 (en) * | 2004-09-25 | 2006-03-30 | Goldschmidt Gmbh | Agent for treating microorganisms e.g. mycobacteria and viruses, and for preparing food preservatives and cosmetic formulation, comprises mixture of fatty acid ester of polyol and salts of short chain monocarboxylic acid |
US20060110416A1 (en) * | 2004-11-23 | 2006-05-25 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Hydroalcoholic cosmetic compositions |
DE102004062775A1 (en) * | 2004-12-21 | 2006-06-29 | Stockhausen Gmbh | Alcoholic pump foam |
US8263098B2 (en) * | 2005-03-07 | 2012-09-11 | Deb Worldwide Healthcare Inc. | High alcohol content foaming compositions with silicone-based surfactants |
DE102005011785A1 (en) * | 2005-03-11 | 2006-09-21 | Goldschmidt Gmbh | Long-term stable cosmetic emulsions |
US7651990B2 (en) * | 2005-06-13 | 2010-01-26 | 3M Innovative Properties Company | Foamable alcohol compositions comprising alcohol and a silicone surfactant, systems and methods of use |
US8815224B2 (en) * | 2005-12-21 | 2014-08-26 | Avon Products, Inc | Hair treatment compositions |
US20070148101A1 (en) * | 2005-12-28 | 2007-06-28 | Marcia Snyder | Foamable alcoholic composition |
-
2005
- 2005-06-13 US US11/151,563 patent/US7651990B2/en active Active
-
2006
- 2006-06-06 EP EP06772279A patent/EP1893167A1/en not_active Withdrawn
- 2006-06-06 CN CN2006800212051A patent/CN101198308B/en active Active
- 2006-06-06 KR KR1020077029560A patent/KR101389199B1/en not_active IP Right Cessation
- 2006-06-06 AU AU2006259687A patent/AU2006259687B2/en active Active
- 2006-06-06 WO PCT/US2006/021904 patent/WO2006138111A1/en active Application Filing
- 2006-06-06 MX MX2007015768A patent/MX2007015768A/en active IP Right Grant
- 2006-06-06 JP JP2008516932A patent/JP5266049B2/en not_active Expired - Fee Related
- 2006-06-06 BR BRPI0613333-9A patent/BRPI0613333A2/en not_active IP Right Cessation
- 2006-06-06 CA CA2610945A patent/CA2610945C/en active Active
- 2006-06-12 TW TW095120904A patent/TW200710220A/en unknown
-
2008
- 2008-01-14 NO NO20080261A patent/NO20080261L/en not_active Application Discontinuation
-
2009
- 2009-09-01 US US12/552,126 patent/US20090326076A1/en not_active Abandoned
-
2010
- 2010-09-09 US US12/878,786 patent/US20100331411A1/en not_active Abandoned
- 2010-09-09 US US12/878,793 patent/US20100327013A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101198308B (en) | 2013-04-10 |
EP1893167A1 (en) | 2008-03-05 |
JP2008546692A (en) | 2008-12-25 |
TW200710220A (en) | 2007-03-16 |
AU2006259687A1 (en) | 2006-12-28 |
MX2007015768A (en) | 2008-02-15 |
CA2610945A1 (en) | 2006-12-28 |
US7651990B2 (en) | 2010-01-26 |
US20100327013A1 (en) | 2010-12-30 |
US20060281663A1 (en) | 2006-12-14 |
US20100331411A1 (en) | 2010-12-30 |
KR20080026546A (en) | 2008-03-25 |
NO20080261L (en) | 2008-03-10 |
WO2006138111A1 (en) | 2006-12-28 |
JP5266049B2 (en) | 2013-08-21 |
BRPI0613333A2 (en) | 2011-01-04 |
CN101198308A (en) | 2008-06-11 |
US20090326076A1 (en) | 2009-12-31 |
KR101389199B1 (en) | 2014-04-24 |
AU2006259687B2 (en) | 2012-03-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2610945C (en) | Foamable alcohol compositions, systems and methods of use | |
US8313758B2 (en) | Method of producing high alcohol content foaming compositions with silicone-based surfactants | |
US7670967B2 (en) | Dispersible alcohol/cleaning wipes via topical or wet-end application of acrylamide or vinylamide/amine polymers | |
US7387787B2 (en) | Water soluble sheet composition | |
KR20000064822A (en) | Post-foaming shaving gel containing poly (ethylene oxide) and polyvinylpyrrolidone | |
AU2004275900A1 (en) | High alcohol content gel-like and foaming compositions | |
US20110287074A1 (en) | Antimicrobial Compositions, Methods of Manufacture Thereof and Articles Comprising the Same | |
US20080311053A1 (en) | Fluorinated phosphate ester surfactant and fluorinated alcohol compositions | |
JP2005509733A (en) | Foaming antibacterial preparation | |
JP2021187834A (en) | Aerosol type hair cleanser |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |