CA2610945A1 - Foamable alcohol compositions, systems and methods of use - Google Patents
Foamable alcohol compositions, systems and methods of use Download PDFInfo
- Publication number
- CA2610945A1 CA2610945A1 CA002610945A CA2610945A CA2610945A1 CA 2610945 A1 CA2610945 A1 CA 2610945A1 CA 002610945 A CA002610945 A CA 002610945A CA 2610945 A CA2610945 A CA 2610945A CA 2610945 A1 CA2610945 A1 CA 2610945A1
- Authority
- CA
- Canada
- Prior art keywords
- dimethicone
- copolyol
- composition
- dimethicone copolyol
- foam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 195
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 79
- 238000000034 method Methods 0.000 title abstract description 10
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract description 162
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 162
- 229940008099 dimethicone Drugs 0.000 claims abstract description 161
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 161
- 239000006260 foam Substances 0.000 claims abstract description 142
- 239000004094 surface-active agent Substances 0.000 claims abstract description 58
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 7
- -1 polyethylene Polymers 0.000 claims description 74
- 239000003974 emollient agent Substances 0.000 claims description 37
- 229920001223 polyethylene glycol Polymers 0.000 claims description 35
- 239000002202 Polyethylene glycol Substances 0.000 claims description 30
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 229920001296 polysiloxane Polymers 0.000 claims description 24
- 229920001451 polypropylene glycol Polymers 0.000 claims description 23
- 239000004599 antimicrobial Substances 0.000 claims description 19
- 239000003380 propellant Substances 0.000 claims description 15
- 239000011734 sodium Substances 0.000 claims description 14
- 229910052708 sodium Inorganic materials 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 11
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 9
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 9
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 229920002554 vinyl polymer Polymers 0.000 claims description 8
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 6
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 6
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 6
- 239000004166 Lanolin Substances 0.000 claims description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 6
- 238000005187 foaming Methods 0.000 claims description 6
- 235000019388 lanolin Nutrition 0.000 claims description 6
- 229940039717 lanolin Drugs 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 6
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 5
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 5
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 5
- 230000004888 barrier function Effects 0.000 claims description 5
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 5
- 229940070765 laurate Drugs 0.000 claims description 5
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 229920000223 polyglycerol Polymers 0.000 claims description 5
- 229960003500 triclosan Drugs 0.000 claims description 5
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 4
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 229960003237 betaine Drugs 0.000 claims description 4
- 150000002170 ethers Chemical class 0.000 claims description 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 4
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims description 4
- 239000011787 zinc oxide Substances 0.000 claims description 4
- 235000014692 zinc oxide Nutrition 0.000 claims description 4
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 claims description 3
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims description 3
- 235000007173 Abies balsamea Nutrition 0.000 claims description 3
- 239000004857 Balsam Substances 0.000 claims description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 3
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 3
- 244000018716 Impatiens biflora Species 0.000 claims description 3
- 108010009736 Protein Hydrolysates Proteins 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- AMZWNNKNOQSBOP-UHFFFAOYSA-M [n'-(2,5-dioxoimidazolidin-4-yl)carbamimidoyl]oxyaluminum;dihydrate Chemical compound O.O.NC(=O)NC1N=C(O[Al])NC1=O AMZWNNKNOQSBOP-UHFFFAOYSA-M 0.000 claims description 3
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 3
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 3
- 229940015825 aldioxa Drugs 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- 235000013871 bee wax Nutrition 0.000 claims description 3
- 239000012166 beeswax Substances 0.000 claims description 3
- YSJGOMATDFSEED-UHFFFAOYSA-M behentrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C YSJGOMATDFSEED-UHFFFAOYSA-M 0.000 claims description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 3
- 239000004327 boric acid Substances 0.000 claims description 3
- 235000010338 boric acid Nutrition 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 235000010980 cellulose Nutrition 0.000 claims description 3
- 229960003260 chlorhexidine Drugs 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 239000002480 mineral oil Substances 0.000 claims description 3
- 235000010446 mineral oil Nutrition 0.000 claims description 3
- FBUKVWPVBMHYJY-UHFFFAOYSA-M nonanoate Chemical compound CCCCCCCCC([O-])=O FBUKVWPVBMHYJY-UHFFFAOYSA-M 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000004246 zinc acetate Substances 0.000 claims description 3
- 235000013904 zinc acetate Nutrition 0.000 claims description 3
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 claims description 2
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 claims description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 2
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- 235000004936 Bromus mango Nutrition 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 2
- 229920000896 Ethulose Polymers 0.000 claims description 2
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 2
- 239000001263 FEMA 3042 Substances 0.000 claims description 2
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 claims description 2
- 240000007228 Mangifera indica Species 0.000 claims description 2
- 235000014826 Mangifera indica Nutrition 0.000 claims description 2
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims description 2
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 2
- 229920002413 Polyhexanide Polymers 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 235000009184 Spondias indica Nutrition 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 244000299461 Theobroma cacao Species 0.000 claims description 2
- 235000009470 Theobroma cacao Nutrition 0.000 claims description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 2
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 2
- HDYRYUINDGQKMC-UHFFFAOYSA-M acetyloxyaluminum;dihydrate Chemical compound O.O.CC(=O)O[Al] HDYRYUINDGQKMC-UHFFFAOYSA-M 0.000 claims description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims description 2
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 2
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- GWDILONWJXSNDD-UHFFFAOYSA-N docosanoic acid;n'-propylethane-1,2-diamine Chemical compound CCCNCCN.CCCCCCCCCCCCCCCCCCCCCC(O)=O GWDILONWJXSNDD-UHFFFAOYSA-N 0.000 claims description 2
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
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- 230000008591 skin barrier function Effects 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
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- 235000012222 talc Nutrition 0.000 claims description 2
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- HFTYFFXNUVBSII-UHFFFAOYSA-M potassium;4-ethoxycarbonylphenolate Chemical compound [K+].CCOC(=O)C1=CC=C([O-])C=C1 HFTYFFXNUVBSII-UHFFFAOYSA-M 0.000 description 1
- DKGFIVSGQRBSOG-UHFFFAOYSA-M potassium;4-hydroxybenzoate Chemical compound [K+].OC1=CC=C(C([O-])=O)C=C1 DKGFIVSGQRBSOG-UHFFFAOYSA-M 0.000 description 1
- MOCBTMXJPWSHOD-UHFFFAOYSA-M potassium;4-methoxycarbonylphenolate Chemical compound [K+].COC(=O)C1=CC=C([O-])C=C1 MOCBTMXJPWSHOD-UHFFFAOYSA-M 0.000 description 1
- TUMYXYVXTFDMTJ-UHFFFAOYSA-M potassium;4-propoxycarbonylphenolate Chemical compound [K+].CCCOC(=O)C1=CC=C([O-])C=C1 TUMYXYVXTFDMTJ-UHFFFAOYSA-M 0.000 description 1
- ZGJADVGJIVEEGF-UHFFFAOYSA-M potassium;phenoxide Chemical compound [K+].[O-]C1=CC=CC=C1 ZGJADVGJIVEEGF-UHFFFAOYSA-M 0.000 description 1
- 229940078492 ppg-17 Drugs 0.000 description 1
- 229940116393 ppg-20 methyl glucose ether Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- PERLTXCUPZSJTA-YTXTXJHMSA-N propan-2-yl (2e,4e)-hexa-2,4-dienoate Chemical compound C\C=C\C=C\C(=O)OC(C)C PERLTXCUPZSJTA-YTXTXJHMSA-N 0.000 description 1
- BFZNCPXNOGIELB-UHFFFAOYSA-N propan-2-yl 10-[5,6-dihexyl-2-(8-oxo-8-propan-2-yloxyoctyl)cyclohex-3-en-1-yl]dec-9-enoate Chemical compound CCCCCCC1C=CC(CCCCCCCC(=O)OC(C)C)C(C=CCCCCCCCC(=O)OC(C)C)C1CCCCCC BFZNCPXNOGIELB-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 229940096792 quaternium-15 Drugs 0.000 description 1
- UKHVLWKBNNSRRR-TYYBGVCCSA-M quaternium-15 Chemical compound [Cl-].C1N(C2)CN3CN2C[N+]1(C/C=C/Cl)C3 UKHVLWKBNNSRRR-TYYBGVCCSA-M 0.000 description 1
- 229940117359 quaternium-24 Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940094944 saccharide isomerate Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- ZLVSYODPTJZFMK-UHFFFAOYSA-M sodium 4-hydroxybenzoate Chemical compound [Na+].OC1=CC=C(C([O-])=O)C=C1 ZLVSYODPTJZFMK-UHFFFAOYSA-M 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000011697 sodium iodate Substances 0.000 description 1
- 235000015281 sodium iodate Nutrition 0.000 description 1
- 229940032753 sodium iodate Drugs 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 235000010294 sodium orthophenyl phenol Nutrition 0.000 description 1
- 229940078442 sodium p-chloro-m-cresol Drugs 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- WNFHGZLVUQBPMA-MHFWOIHZSA-M sodium;(2s,3s,4s,5s)-2,3,4,5-tetrahydroxy-6-oxohexanoate Chemical compound [Na+].O=C[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O WNFHGZLVUQBPMA-MHFWOIHZSA-M 0.000 description 1
- OGBHACNFHJJTQT-UHFFFAOYSA-M sodium;4-butoxycarbonylphenolate Chemical compound [Na+].CCCCOC(=O)C1=CC=C([O-])C=C1 OGBHACNFHJJTQT-UHFFFAOYSA-M 0.000 description 1
- DPHAGKRZIJHMNL-UHFFFAOYSA-M sodium;4-chloro-3-methylphenolate Chemical compound [Na+].CC1=CC([O-])=CC=C1Cl DPHAGKRZIJHMNL-UHFFFAOYSA-M 0.000 description 1
- QYNMSPKSYXPZHG-UHFFFAOYSA-M sodium;4-ethoxycarbonylphenolate Chemical compound [Na+].CCOC(=O)C1=CC=C([O-])C=C1 QYNMSPKSYXPZHG-UHFFFAOYSA-M 0.000 description 1
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
- DKYPZNSPQXLRRQ-UHFFFAOYSA-M sodium;undec-10-enoate Chemical compound [Na+].[O-]C(=O)CCCCCCCCC=C DKYPZNSPQXLRRQ-UHFFFAOYSA-M 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940057981 stearalkonium chloride Drugs 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 229940098760 steareth-2 Drugs 0.000 description 1
- 229940100458 steareth-21 Drugs 0.000 description 1
- UHCGLDSRFKGERO-UHFFFAOYSA-N strontium peroxide Chemical compound [Sr+2].[O-][O-] UHCGLDSRFKGERO-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- ILLKMACMBHTSHP-UHFFFAOYSA-N tetradecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ILLKMACMBHTSHP-UHFFFAOYSA-N 0.000 description 1
- JYKSTGLAIMQDRA-UHFFFAOYSA-N tetraglycerol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO JYKSTGLAIMQDRA-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 235000010296 thiabendazole Nutrition 0.000 description 1
- 239000004308 thiabendazole Substances 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 229960004546 thiabendazole Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 description 1
- GAAKLDANOSASAM-UHFFFAOYSA-N undec-10-enoic acid;zinc Chemical compound [Zn].OC(=O)CCCCCCCCC=C GAAKLDANOSASAM-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940004858 usnic acid Drugs 0.000 description 1
- ICTZCAHDGHPRQR-UHFFFAOYSA-N usnic acid Natural products OC1=C(C)C(O)=C(C(C)=O)C2=C1C1(C)C(O)=C(C(=O)C)C(=O)C=C1O2 ICTZCAHDGHPRQR-UHFFFAOYSA-N 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 150000003739 xylenols Chemical class 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229940118257 zinc undecylenate Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/896—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate
- A61K8/898—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/82—Compounds containing silicon
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0094—High foaming compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/201—Monohydric alcohols linear
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
- C11D3/225—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin etherified, e.g. CMC
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
Abstract
A composition, systems for dispensing the composition and methods for the use of the composition are described. The composition comprises: (A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity; (B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.
Description
FOAMABLE ALCOHOL COMPOSITIONS, SYSTEMS AND METHODS OF USE
The present invention relates to foamable alcohol compositions, systems for dispensing the compositions and methods for the use of the compositions.
Background Foamable soap products contain a significant quantity of air. While these compositions can be economically manufactured as compared with non-foamable compositions, the formulation of foainable compositions comprising a high alcohol content has generally required the compositions to be provided as aerosol products which include a propellant (e.g., hydrocarbon, fluorocarbon, compressed gas) to facilitate foaming when the composition is dispensed from an aerosol container. These aerosol compositions can also include polymeric gelling agents, moderately high molecular weight (e.g., C16 to C22) alcohols and nonionic surfactants, for example. Aerosol products are costly to manufacture because of the need for a pressurized container and the inclusion of a foaming propellant.
In the formulation of non-aerosol soap products having a high alcohol content, surfactants have been included in such compositions to facilitate some level of foaming when the compositions are dispensed through a mechanical pump or the like. Surfactants can facilitate at least some degree of initial foaming, but such non-aerosol foams are often unstable and tend to collapse as soon as they are dispensed. While some fluorochemical surfactants have been known to facilitate more stable foams in non-aerosol compositions, fluorochemical surfactants may raise environmental concerns.
There is a need to provide foainable alcohol-containing compositions that are formulated to be anti-microbial and which can be applied to the skin (e.g., the hands).
There is a need for alcohol-containing compositions that will forin a stable foam in the absence of an aerosol propellant and which will deliver alcohol to the skin for rapid skin disinfection.
Within the foregoing need, it is desirable to provide foamable, low viscosity, alcohol-containing compositions that are safe and efficacious while providing properties that may be desired by tlie consumer.
Summary In one aspect, the present invention provides a composition, comprising:
(A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity;
(B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.
In another aspect, the invention provides a system comprising a container and the composition as described above, the composition contained within the container under pressure and a propellant present within the composition.
In still another aspect, the invention provides a system comprising a dispenser comprising a reservoir and a hand pump; and the composition as described above contained within the reservoir.
In still another aspect, the invention provides a skin sanitizer comprising the composition as described above.
In still another aspect, the invention provides a pre-surgical hand scrub comprising the composition as described above.
In still another aspect, the invention provides a method for sanitizing a surface, comprising applying a volume of the composition as described above to the surface, the composition being in the form of a stable foam.
It will be appreciated that the terms used herein will be understood as being defined according to the understanding of those skilled in the art at the time of the present invention. However, certain terms used herein shall be understood as having the meaning that is expressly set forth herein:
"Builder" refers to a material that can be incorporated as a component in the compositions of the invention to aid in the creation of a stable foam when the composition is dispensed from an aerosol or a non-aerosol dispenser. Compositions comprising a builder can produce lower foam densities (greater volume) as compared to the same volume of the composition in the absence of the builder.
"Emollient" as used herein refers broadly to materials which are capable of maintaining or improving the moisture level, compliance, or appearance of the skin.
"Foam" refers to a frothy mass of bubbles formed on or from a liquid (e.g., the compositions of the invention).
"HLB" means the "hydrophile-liphophile balance," or the balance between the oil soluble and water soluble moieties in a surface active molecule or surfactant.
"Polymer" as used herein refers to a natural or synthetic molecule having repetitive units and a number average molecular weight of at least 20,000.
As used herein, "poly(propylene oxide)" and "poly(ethylene oxide)" are intended to be syiionymous with "polypropylene glycol" or "PPG" and "polyethylene glycol" or "PEG,"
respectively. Poly(propylene oxide) and poly(ethylene oxide) are also abbreviated herein as "PPO" and "PEO," respectively.
"Solvent", "solvent system" or "hydroalcoholic solvent" as used herein refer to the alcohol and water combination in the present invention.
"Stable," as used when referring to a foamed composition, refers to foam that maintains a measurable height for a period of time of at least about 5 seconds following creation of the foam (e.g., by shaking the composition or by dispensing the composition from an aerosol or non-aerosol dispenser at ambient temperature). The stability of a particular foam may further be expressed in terms of the height of the foam after a measured period of time (e.g., 6 mm after 1 minute). Foam height measurements are further discussed in the Examples.
Those skilled in the art will more fully understand the various features and aspect of the invention upon consideration of the remainder of the disclosure, including the Detailed Description, the Examples and the appended claims.
Detailed Description The invention provides a foamable composition coinprised of alcohol, surfactant and builder. The compositions of the invention may be aqueous compositions.
Optional ingredients such as antimicrobials and/or emollients, for example, may be included to provide or enhance the properties of the compositions. The compositions of the invention provide the benefits of a foam for the disinfection of skin by providing a coinposition with a sheer thinning viscosity that is better than that for gelled compositions and which can be more easily rubbed onto sensitive tissue. Additionally, the compositions of the invention generally will dry quicker than a gel following application to a surface such as the hands, for example.
Alcohol The compositions of the invention will include at least one alcohol that provides the ability to rapidly kill a broad spectrum of microbes. The compositions of the invention are suitable for use on the skin or other surfaces and may be used as a disinfectant for the hands, for exainple. In embodiments of the invention, the alcohol or alcohols are monohydric alcohols. Typically, the compositions of the invention comprise alcohols having lower hydrocarbon chain lengths such as C2 to C4 alcohols. In some embodiments, the compositions of the invention comprise a single alcohol. In other embodiments, a blend of two or more alcohols may be present. In some embodiments, the alcohol will consist of ethanol. In still other embodiments, the alcohol will consist of propanol (e.g., n-propanol and/or isopropanol). In still other embodiments, the alcohol will consist of butanol (e.g., n-butanol, sec-butanol and tert-butanol). In some embodiments the alcohol is dissolved in water to provide an alcohol-water solvent.
Embodiments of the invention may comprise compositions having an alcohol content between about 35% and about 99.5% by weight. In some embodiments, the compositions of the invention will have an alcohol content within the range from about 60%
to about 80%. Compositions having an alcohol content within the foregoing ranges typically provide an efficacious bacterial kill.
Surfactants At least one surfactant is present in the compositions of the invention. In some embodiments, surfactant may be present in the coinpositions of the invention at concentration ranges from about 0.1 % to about 10% by weight, based on the total weight of the composition. In some embodiments, the surfactant may be present in a composition at a concentration ranging from about 0.5% to about 5% by weight, based on the total weight of the composition. Those skilled in the art will appreciate that certain surfactants may impart a tacky or even a greasy feel to a composition when the surfactant concentration is greater than 5% by weight. While such surfactant concentrations are contemplated as within the scope of the invention, the skilled artisan may wish to consider the cosmetic effects of surfactant concentrations when formulating a composition for use by the consumer. In some embodiments, the compositions of the invention are formulated with non-fluorinated surfactants and without the need for fluorochemical propellants.
Specific surfactants useftil in the invention include dimethicone surfactants.
Examples of dimethicone surfactants include dimethicone copolyols - a polymer of dimethylsiloxane with polyoxyethylene (PEO) and/or polyoxypropylene (PPO) side chains. In some embodiments, these surfactants can be hydroxyl, methoxy or butoxy terminated, and the molar ratio of PEO to PPO (PEO/PPO) can range from 0/50 to 50/0 and the molecular weight of the dimethicone portion can range from 200 to 20,000. The surfactants used in the invention can comprise specific dimethicone surfactants. Specific surfactants suitable for use in embodiments of the invention include, without limitation, methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 3000;
dimethicone with a pendant ether of 35/65 (w/w) polyethylene glycol /
polypropylene glycol copolymer having a combined average molecular weight of about 7,000;
dimethicone copolyol witll 18/18 (molar ratio) polyethylene glycol /
polypropylene glycol;
a diinethicone copolyol with 17/18 (molar ratio) polyethylene glycol /
polypropylene glycol; a dimethicone copolyol with polyethylene glycol / polypropylene glycol - methoxy terminated having an average molecular weight of about 20,000 and a HLB of 9-12;
dimethicone copolyol witli a methoxy- terminated polyethylene glycol having a combined average molecular weight of about 3000; dimethicone copolyol with a methoxy-terminated polyethylene glycol having a combined average molecular weight of about 6000; dimethicone copolyol with a hydroxy terminated polyethylene glycol having a combined average molecular weight of about 5000 with an HLB of 13-17;
dimethicone copolyol lactate; silicone copolyol pelargonate; hydroxyl-capped dimethicone copolyol;
hydroxyl-terminated polyethylene glycol- 12 dimethicone; dimethicone copolyol laurate;
Silicone Quaternary 1; hydroxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 4000; methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 600; Silicone Quaternary 2 (Myristyl); sodium dimethicone copolyol acetyl methyltaurate; butoxy-terminated poly(propylene oxide) dimetllicone having an average molecular weight of about 3,000;
and silicone copolyol isostearate.
Additionally, the following surfactants may be usefi,il in the invention:
dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethocone copolyol almondate, dimethicone copolyolamine, dimethicone copolyol avocadoate, dimethicone copolyol beeswax, dimethicone copolyol behenate, dimethicone copolyol benzoate, dimethicone copolyol bishydroxy ethylamine, dimethicone copolyol borageate, dimethicone copolyol butyl ether, dimethicone copolyol cocoa butterate, dimethicone copolyol crosspolymer, dimethicone copolyol dhupa butterate, dimethicone copolyol ethyl etlier, dimethicone copolyol hydroxy stearate, dimethicone copolyol isostearate, dimethicone copolyol kokum butterate, dimethicone copolyol lactate, diinetllicone copolyol laurate, dimethicone copolyol mango butterate, dimethicone copolyol meadowfoamate, dimethicone copolyol methyl ether, dimethicone copolyol mohwa butterate, dimethicone copolyol octyldodecyl citrate, dimethicone copolyol olivate, dimethicone copolyol phosphate, dimethicone copolyol phthalate, dimethicone copolyol sal butterate, dimethicone copolyol shea butterate, dimethicone copolyol stearate, dimethicone copolyol undecylenate, dimethicone hydroxypropyl trimonium chloride, dimethicone propyl pg-betaine, polysilicone-10, polysilicone-8, dimethcone propylethylenediamine behenate, amino bispropyl dimethicone aminoethylaminopropyl dimethicone, behentrimonium dimethicone copolyol phthalate, bis-aminopropyl copolyol aininopropyl dimethicone, bis-hydroxyethoxypropyl dimethicone, cetyl triethylmonium dimethicone copolyol succinate, dimethicone copolyol sulfate, dimethicone copolyol phosphate, dimethicone polyglycerol, disodium copolyol dimethicone sul'fosuccinate, copolyol polydimethylsiloxyethyl dimethicone, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, copolyol oleyl ether dimethicone, sodium carboxydecyl copolyol dimethicone.
Combinations of two or more of the foregoing dimethicone surfactants in a single composition are also contemplated within the scope of the invention Builder At least one builder may be included in the compositions of the invention in order to stabilize the foams produced from the compositions when the coinpositions are shaken, or when they are dispensed from either an aerosol or a non-aerosol dispenser. In some embodiments, the inclusion of certain builders can provide cosmetic attributes to the compositions of the invention. Suitable builders can include one or more of the following:
poly(ethylene oxide), hydroxyethyl cellulose, hydroxypropyl cellulose. In some embodiments, the builder will comprise only one of the foregoing. In other embodinients, the builder will comprise a combination of two or more of the foregoing builder. In some embodiments, the builder will coinprise a poly(ethylene oxide) having an average molecular weight in the range from about 200,000 to about 4,000,000. One poly(ethylene oxide) suitable for use in the compositions of the invention is that know under the designation POLYOXTM and commercially available from Dow Chemical Canada Inc., Sarnia, Ontario. Suitable POLYOX compositions include those designated as "WSR
N12K" having an average molecular weight of 1,000,000; "WSR-301" having an average molecular weight of 4,000,000; "WSR N60K" having an average molecular weight of 2,000,000; and "WSR N-80" having an average molecular weight of 200,000.
The builder, when included in the compositions of the invention, may be present at concentrations less than or equal to about 0.1%. In some embodiments, the builder is present in the coinposition at concentrations of about 0.06%.
In general, the builder enhances the stability of the foam produced when the composition of the invention is shalcen or when the composition is dispensed. Builders suitable for use in the invention will include those that provide or enhance the stability of the foam - i.e., those that provide a measurable foam height over at least about 5 seconds following the creation of the foam. In some embodiments, the builder is soluble in the alcohol that is used in the compositions of the invention. In some embodiments, the builder will be swellable within the alcohol. In still other embodiments, the builder can be characterized as dispersible in the aleohol.
In some embodiments, suitable foam builders include compounds comprising high molecular weight polymers. In some embodiments, these polymers are alcohol or hydroalcoholic soluble. Specific polymers useful in the invention include, without limitation: Poly(ethylene oxide) (molecular wt of 100,000 to 10,000,000), high molecular weight polyetliylene - polypropylene copolymers, hydroxyethyl cellulose, hydroxypropyl cellulose. When present, the polymer will be at a concentration of between about 0.001 and about 5%. In some embodiments, the polymer concentration will be between about 0.01 % and about 0.5%.
Polymers within the following classes can be useftil as builders in the compositions of the invention: hydroxypropyl guar, polyquaternium-4, polyquaternium-10, cetyl hydroxyethylcellulose, ethylhydroxy ethyl cellulose, polyglycerol, high molecular wt.
polyoxamer, high molecular wt. polyoxamine, polyacrylamide, high molecular wt polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-l to polyquaternium-47, polyvinyl methyl ether, butylated poly vinyl pyrrolidone, hydroxypropyl methylcellulose; hydroxypropyl cellulose;
crosslinked and nonerosslinlced homopolyiner or crosslinlced and noncrosslinlced copolymer containing n-vinyl lactam monomeric units.
Non-limiting examples of N-vinyl lactam monomers are N-vinyl-2-pyrrolidone; N-vinyl-2-valerolactam; N-vinyl-2-caprolactam; and mixtures of any of the foregoing.
Typically, the poly(N-vinyl lactain) is a homopolymer of N-vinyl-2-pyrrolidone.
Nonlimiting examples of comonomers useful with the aforementioned N-vinyl lactam monomers include N,N-dimethylacrylarnide, acrylic acid, methacrylic acid, hydroxyethylmethacrylate, acrylamide, 2-acrylamido-2-methyl-l-propane sulfonic acid or its salt, and vinyl acetate.
While the foregoing builders can be added to the compositions of the invention individually, combinations of two or more such builders are also contemplated within the scope of the invention as well as derivatives thereof.
Viscosity of Compositions The compositions of the invention will typically be of very low viscosities at 23 C. In some embodiments, the compositions of the invention can have different viscosities depending on the state of the composition. For example, a composition in a pre-dispensed condition, i.e., it is in a "pre-foamed" state in a dispenser prior to being dispensed, can have a viscosity within the range from about 0.5 to about 100 cps at 23 C. In some embodiments, the prefoam viscosities of compositions of the invention will range from about 0.5 cps to about 50 cps. In still other embodiments, the prefoam viscosities of compositions of the invention will range fiom about 0.5 cps to about 20 cps.
When a composition of the invention is dispensed from a non-aerosol pump-type dispenser, the composition will foam, and the foam will typically be of a higher viscosity than the viscosity of the liquid "non-foamed"composition prior to dispensing. It will also be appreciated that the addition of an emollient and/or other optional ingredients (discussed herein) can also have an affect on viscosity (either positively or negatively).
Foam Density The compositions of the invention will foam when shaken of dispensed from a dispenser.
It will be appreciated that the foam densities of the compositions can vary depending on any of a variety of factors. For example, the viscosity of the unfoamed composition, discussed above, can have an effect on foam density. Moreover, the design of the dispenser or the non-aerosol pump used to deliver the foamed composition can have an effect on the foam density of the composition to the extent that the dispenser and/or the pump effect the foaining of the composition. Additionally, the amount of force applied to the pump and the relative speed at which the pump is operated when dispensing the composition can also have an effect on the foaming of the composition and its resulting viscosity.
Optional Ingredients In addition to alcohol-water, surfactant and builder, the compositions of the present invention may optionally include other ingredients such as salts, emollients, stabilizers, antimicrobials, fragrances, therapeutic agents, propellants and additional emulsifiers.
Each of these optional ingredients along with the effect each has upon the properties of the final composition is discussed below.
Emollients can optionally be added to the compositions of the invention so that the compositions can be provided in a form that is capable of increasing the moisture content of the stratum corneum wlien the composition is applied to a user's hands, for example.
Emollients are generally separated into two broad classes based on their function. The first class of emollients fttnction by forming an occlusive barrier to prevent water evaporation from the stratum corneum. The second class of emollients penetrate into the stratum corneum and physically bind water to prevent evaporation. The first class of emollients is subdivided into compounds which are waxes at room temperature and compounds which are liquid oils. The second class of emollients includes those which are water soluble and are often referred to as humectants.
As referred to herein, the alcohol-water, surfactant and builder components used in the compositions of the invention are separate and distinct from components identified as emollients and optionally added to the composition. Emollients may be added to the compositions in addition to the aforementioned silicone block surfactants and builder compounds which may also aid in maintaining or improving the skin condition of the user.
In some embodiments, added emollients may be included the compositions of the invention at a concentration between about 0 and about 30% by weight. In some embodiments, the added emollient can be present in the composition at a concentration between about 0.5% and about 20%. In still other embodiments, the emollient concentration can be between about 1% and about 12% by weight. Suitable emollients may be selected from any of the classes lcnown in the art. A general list of useful emollients appears, for example, in U.S. Patent No. 4,478,853 and in EPO
patent application 0 522 624A1 as well as in the CTFA Cosmetic Ingredient Handbook published by The Cosmetic, Toiletry, and Fragrance Association, Wash. D.C. (1992) under the listings "Skin Conditioning agents," "emollients," "humectants,"
"miscellaneous" and "occlusive."
In some embodiments, suitable emollients may be chosen from the following nonlimiting list of general emollients, occlusive emollients and humectants. Examples of general emollients include short chain alkyl or aryl esters (CI -C6) of long chain straight or branched chain alkyl or allcenyl alcohols or acids (C8-C32) and their polyethoxylated derivatives; short chain alkyl or aryl ester (C I -C6) of C4-C12 diacids or diols optionally substituted in available positions by -OH; alkyl or aryl C1-Clo esters of glycerol, pentaerythritol, etliylene glycol, propylene glycol, as well as polyethoxylated derivatives of these and polyethylene glycol; C12-C22 allcyl esters or ethers of polypropylene; C12-C22 alkyl esters or ethers of polypropylene/polyethylene glycol copolymer.
Examples of occlusive emollients include cyclic and linear dimethicones;
polydialkylsiloxanes; polyaryialkylsiloxanes; long chain (Cg-C36) alkyl and alkenyl esters of long straight or branched chain alkyl or alkenyl alcohols or acids; long chain (C8-C36) alkyl and alkenyl amides of long straight or branched chain (Cg-C36) alkyl or alkenyl amines or acids; hydrocarbons including straight and branched chain alkanes and alkenes such as squalene, squalane and mineral oil; jojoba oil; polysiloxane polyalkylene copolymers; shoi-t chain alkyl or aryl esters (CI-C36) of C12-C22 diacids or diols optionally substituted in available positions by OH such as diisopropyl dimer dilinoleate; and C12-C22 alkyl and alkenyl alcohols; long chain alkyl or aryl esters (C8-C36) of C12-C22 diacides or diols optionally substituted in available positions by -OH, such as diisostearyl dimer dilinoleate; lanolin and lanolin derivatives; and beeswax and.its derivatives.
Non-limiting examples of preferred humectant type emollients include glycerol, polyglycerols (including: diglycerol, triglycerol, polyglycerin-3, tetraglycerol, hexaglycerol, decaglycerols) propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol (PEG-2 to PEG-45M, preferably a molecular weight between about 300 and 1,000), sorbitol, polyhydric alcohol ethoxylates (e.g. sorbeth-6, sorbeth-30, glycereth-1 to glycereth-3 1) methoxides of polyethylene glycol (Methoxy PEG-2 to Methoxy PEG-100) methoxides of polyhydric alcohol ethoxylates (e.g. glycereth-methoxide), pantothenol, gluconic acid salts and the like. Other huinectant-type agents like that could also be employed include: 1,2,6-hexanetriol, acetamide mea, aluminum hydroxide, arginine pea, butoxypropanol, butylene glycol, dimethyl imidazolidinone, dimethylsilanol hyaluronate, dipotassium glycyrrhizate, erythritol, ethoxy-diglycol, fructose, glucainine, gluconic acid, glucose, glucose glutamate, glucuronic acid, glutamic acid, glycogen, glycyrrhizic acid, heilmoor clay, hexacosyl glycol, histidine, hyaluronic acid, hydrogenated honey, hydrogenated starch, hydrolysate,liydrolyzed collagen, hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydrolyzed keratin, hydrolyzed silk, hydrolyzed soy protein, hydrolyzed wheat protein, hydroxyethyl sorbitol, inositol, inositol hexa-pea, lactamide mea, lactic acid, lactitol, lactose, lysine pea, magnesium pea, maltitol, manganese pea, mamiitol, mel (honey extract), menthyl pea, methyl gluceth-10, methyl gluceth-20, pea (pidolic acid), lactainide, polydextrose, polyglucuronic acid, polyglyceryl sorbitol, potassiuin pea, ppg-20 methyl glucose ether, ppg-38-buteth-37, saccharide isomerate, serica, silk amino acids, sodium carboxymethyl chitin, sodium lactate, sodium mannuronate methylsilanol, sodium pea, sodium pea methylsilanol, sodium polyglutamate, soluble collagen, sorbitol, sucrose, tea-lactate, tea-pea, trehalose, trilactin, urea, xylitol, zea mays, zinc pea, and combinations thereof.
The addition of one or more emollients may affect the viscosity and stability of the compositions of the present invention. In some embodiments, a single emollient may be added to the coinposition. hi some embodiments, two or more emollients may be added to the composition. While any of a variety of emollients may be added to the formulations of the present invention, some embodiments will include wax and oil type emollients either alone or combined with water soluble emollients. In some embodiments of the invention, emollient systems can be coinprised of humectants in addition to occlusive wax and oil emollients in concentrations that achieve a moisturizing effect and which maintains and improves the condition of the skin upon repeated use. Emollierits may be non-comedogenic and chosen to avoid skin irritation or sensitization reactions.
In addition to the antimicrobial effects attributable to the presence of alcohol in the compositions of the present invention, one or more other antimicrobial agents ("secondary antimicrobial agents") may be added to enhance the antimicrobial properties of the compositions when they are used as pre-surgical hand scrubs or pre-surgical patient skin scrub replacements, for example. In other words, the foamed composition of the present invention can deliver a secondary antimicrobial agent to the skin. In some embodiments, the secondary antimicrobial agent is added in levels up to 10% by weight of the total composition. In some embodiments, it may be desirable to incorporate a secondary antimicrobial agent in the compositions of the invention to provide continued antimicrobial resistance to the growth or regrowth of the microorganisms following evaporation of the alcohol.
Non-limiting exainples of suitable secondary antimicrobial agents include parachlorometaxylenol; triclosan; chlorhexidine and its salts such as chlorhexidine gluconate, poly hexamethylene biguanide and its salts such as poly hexamethylene biguanidine chloride, iodine, idodophors; fatty acid monoesters; poly-n-vinyl pyrrolidone-iodophors; silver oxide, silver and its salts, peroxides (e.g. hydrogen peroxide), antibiotics (e.g. neomycin, bacitracin, and polymixin B).
Additionally, other suitable ingredients can be used in the compositions of the invention to suppress the regrowtli or possibly treat an infection of microorganisms, such as: 2,2-thiobis(4-chlorophenol); 4,4-isopropylidenediphenol; 5-amino-6-chloro-o-cresol;
acetaminosalol; alcloxa; aldioxa; aluminum acetate; aluminum benzoate;
aluminum diacetate; aluininum formate; aluminum phenolsulfonate; ammonium iodide;
ammonium phenolsulfonate; benzisothiazolinone; benzotriazole; benzoxiquine;
benzylparaben;
berberine chloride; boric acid; cetethyl morpholinium ethosulfate;
cetethyldimonium bromide; cetrimonium tosylate; cetylpyridinium chloride; chloramine-t;
chlorothymol;
cloflucarban; cocotrimonium chloride; colloidal sulfur; copper usnate;
dedmhydantoin;
dedm hydantoin dilaurate; dequalinium acetate; dequalinium chloride;
dibromopropamidine diisethionate; dichloro-m-xylenol; dichlorophene;
dichlorophenyl imidazoldiox6lan; diiodomethyltolylsulfone; dimethyl hydroxymethyl pyrazole;
dimethylaminostyryl heptyl methyl thiazolium iodide; dodecylbenzyltrimonium chloride;
domiphen bromide; ferulic acid; fluorosalan; glyoxal; hydroxymethyl dioxoazabicyclooctane; lzydroxypropyl bistrimonium diiodide; ichthammol;
isodecylparaben; isopropyl sorbate; lapyrium chloride; laurtrimonium trichlorophenoxide;
lauryl iso-quinolinium bromide; lauryl isoquinolinium saccharinate;
laurylpyridinium chloride; m-cresol; mandelic acid; MDM hydantoin; MEAa-iodine; melaleuca alternifolia;
methyl-benzethonium chloride; mixed cresols; nonoxynol-12 iodine; nonoxynol-9 iodine;
o-cresol; oxyquinoline benzoate; oxyquinoline sulfate; p-chlorophenol; p-cresol; PEG15 dedm hydantoin; PEG-15 dedm hydantoin stearate; PEG-5 dedm hydantoin; PEG-5 dedm hydantoin oleate; phenol; phenoxyethylparaben; phenyl salicylate; polymethoxy bicyclic oxazolidine; potassium iodide; potassium lactate; potassium phenoxide;
potassium troclosene; quartronium-14; quaternium-24; quaternium-8;
ricinoleamidopropyltrimonium methosulfate; sodium iodide; sodium p-chloro-m-cresol; sodiuin phenolsulfonate; sodium phenoxide; sodium usnate; steapyrium chloride; strontium peroxide; tea-sorbate; tetrabutyl ammonium bromide; thiabendazole; triacetin; undecylenamide dea; undecylenamide mea;
undecylenamidopropyltrimonium methosulfate; tuidecyleneth-6; undecylenoyl peg-paraben; usnic acid; zinc acetate; zinc borate; zinc phenolsulfonate; zinc sulfate; zinc undecylenate; and coinbinations of the foregoing.
The following actives could also be of use to also reduce regrowth of microorganisms on skin: 2-bromo-2-nitropropane- 1,3 -dial; 4-hydroxybenzoic acid; 5-bromo-5-nitro-1,3-dioxane; 7-ethylbicyclooxazolidine; ammonium benzoate; ammonium bisulfite;
ammonium propionate; ammonium sulfite; behentrimonium chloride; benzalkonium bromide; benzallconium chloride; benzalkonium saccharinate; benzethonium chloride;
benzoic acid; benzyl alcohol; benzylhemiformal; bromochiorophene; butyl benzoate;
butylparaben; calcium benzoate; calcium paraben; calcium propionate; calcium salicylate;
calcium sorbate; calcium undecylenate; cetalkonium chloride; cetearalkonium bromide;
cetrimonium bromide; cetrimonium chloride; chloroacetamide; chlorobutanol;
chlorophene; chloroxylenol; chlorphenesin; climbazole; dehydroacetic acid;
diazolidinyl urea; dibromohexamidine isethionate; dichlorobenzyl alcohol; dimethyl oxazolidine;
DMDM hydantoin; ethyl benzoate; ethylparaben; formaldehyde; formic acid;
glutaral;
hexamidine; hexamidine diisethionate; hexamidine paraben; hexetidine;
hydrogenated tallowtrimonium chloride; iinidazolidinyl urea; iodopropynyl butylcarbamate;
isobutyl benzoate; isobutylparaben; isopropyl benzoate; isopropyl cresols;
isopropylparaben;
lauralkonium bromide; lauralkonium chloride; laurtrimonium bromide;
laurtrimonium chloride; magnesium benzoate; magnesium propionate; magnesium salicylate; MEA
o-phenylphenate; MEA-benzoate; MEA-salicylate; MEA-undecylenate; methenamine;
methyl benzoate; methylchloroisothiazolinone; methyldibromo glutaronitrile;
methylisothiazolinone; methylparaben; myristalkonium chloride; myristalkonium saccharinate; myrtrimonium bromide; o-cymen-5-01; o-phenylphenol; olealkonium chloride; p-chloro-m-cresol; phenoxyethanol; phenoxyisopropanol; phenyl benzoate;
phenyl mercuric acetate; phenyl mercuric benzoate; phenyl mercuric borate;
phenyl mercuric bromide; phenyl mercuric chloride; phenylparaben; piroctone olamine;
polyaminopropyl biguanide; potassium benzoate; potassium butylparaben;
potassium ethylparaben; potassium metabisulfite; potassium methylparaben; potassium o-phenylphenate; potassium paraben; potassium propionate; potassium propylparaben;
potassium salicylate; potassium sorbate; potassium sulfite; propionic acid;
propyl benzoate; propylparaben; quaternium-15; salicylic acid; sodium benzoate;
sodium bisulfite; sodium butylparaben; sodium dehydroacetate; sodium ethylparaben;
sodium formate; sodium hydroxyinethylglycinate; sodium iodate; sodium metabisulfite;
sodium methylparaben; sodium o-phenylphenate; sodium paraben; sodium propionate;
sodium propylparaben; sodium salicylate; sodium sorbate; sodium sulfite; sodium undecylenate;
sorbic acid; soytrimonium chloride; stearalkonium chloride; steartrimonium chloride;
tallowalkonium chloride; tallowtrimonium chloride; thimerosal; triclocarban;
triclosan;
undecylenic acid; zinc pyrithione.
The present invention further encompasses embodiments incorporating antimicrobials such as benzoyl peroxide so that the composition may be useful as an acne medication, for example. In some embodiments, the compositions of the present invention may also be formulated with barrier compounds to form barrier creams and lotions.
Materials which may be added to provide barrier protection for use as skin barriers to protect against diaper rash include but are not limited to 0.1 to 60% aldioxa, allantoin, aluininum acetate, aluminum hydroxide, bisinuth subnitrate, boric acid, calamine, cellulose (microporous), cholecalciferol, cocoa butter, cod liver oil (in combination), colloidal oatmeal, cysteine hydrochloride, dexpantllenol, dimethicone, glycerin kaolin, lanolin (in combination), live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsain oil, pertrolatum, protein hydrolysate (1-leucine, 1-isoleucine, 1-methionine, 1-phenylalanine, and 1-tyrosine), racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate and zinc oxide.
In some embodiments, the compositions of the invention may comprise one or more formulations containing antifiingal agents for the treatment of fiingal infections of the skin such as athlete's foot and the like.
While some embodiments will include one additional secondary antimicrobial agent, other embodiments of the invention can include two or inore additional secondary antimicrobials. While the foregoing secondary antimicrobials can be added to the compositions individually or singly, combinations of two or more of the foregoing secondary antiinicrobials are also contemplated within the scope of the invention.
In some embodiments, the compositions of the present invention may be formulated into non-aerosol products that can be dispensed from a reservoir using a hand-pump, for example, to dispense an amount of the composition whenever the hand pump is actuated.
The amount of the composition dispensed by the pump may or may not be metered so that the amount of composition dispensed may or may not be consistent. Moreover, the compositions of the invention are not limited to being dispensed from only one type of dispenser or through only one type of hand pump.
In some embodiments, the compositions are capable of being forinulated into an aerosol foam or a mousse by addition of propellant to the composition. Suitable propellants can be chosen from chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorinated alkanes, and lower alkanes (C1- C5) as well as nitrous oxide diinethyl ether and other solvent-soluble propellants. Suitable lower alkanes include propane, butane, and isobutane, for example. In some embodiments, the propellant can comprise a 70/30 mixture of propane/isobutane. In order to produce an aerosol composition the composition is first forinulated and charged into an appropriate pressure rated container. A suitable propellant may then be added to the composition under pressure at approximately 2-30% preferably 3-20% by volume. The propellant may form a separate layer on the composition or the propellant may be emulsified or miscible in the composition.
The compositions of the invention can be used in any of a variety of applications including use as a sanitizer for application to a surface. The compositions of the invention are suitable for use on mammalian skin including the human hands. In some embodiments, the compositions may be used as a pre-surgical hand scrub. In non-aerosol formulations of the invention, the compositions may be contained in a non-aerosol dispenser equipped with a conventional hand ptunp, and the composition may be pumped onto the hands or other areas of the body. The purnping action required to dispense the compositions will create a discrete volume of a dispensed coinposition in the form of a stable foam.
Lilcewise, in embodiments comprising an aerosol, the aerosol formulation may be dispensed fi-om a pressurized container in a discrete volume of foamed composition. After dispensing, the foazn inay be spread upon the si.trface of the slcin to sanitize the skin, the hands or the like. While some residue may remain on the skin following evaporation of the alcohol coinponent, the residue can comprise emollients or the like to provide a desired cosmetic effect. Consequently, the compositions of the invention provide a means for sanitizing skin in the form of a foamable composition which does not need to be rinsed from the skin following application of the foam to the area in need of sanitization.
Alternatively, undesired residue remaining on the surface can be rinsed off with water, for example.
From the foregoing, it will be appreciated that the present invention also encompasses systems for dispensing the coinpositions comprising a reservoir and an amount of composition retained therein, and means for dispensing the composition from the reservoir.
The coinpositions of the present invention may be prepared by a variety of techniques and the ingredients may be added to one another in any order of addition. To ensure a composition of maximum stability, the components may be subjected to high shear (e.g.
homogenized) for a limited time period.
EXAMPLES
The following non-limiting Examples are provided to illustrate features of the invention.
are not intended to limit the scope of the invention. All percent amounts are weight/weight percent (wt/wt%) unless otherwise noted.
Preparation of Compositions The coinpositions in the Examples were prepared in 60 gram samples by combining all components in a glass jar and rolling the jar overnight, on a mechanical roller. The foam builder was introduced to the mixture by first preparing a premix of the foam builder at ranges from 0.5%, to 8.0% wt/wt, prepared in water/alcohol. The appropriate weight of premix was then added to the mixture containing the other coinponents prior to the step of mixing by rolling overniglzt.
According to the Material Safety Data Sheets of certain dimethicone copolyol surfactants, the surfactants are lcnown to contain significant quantities of PEO/PPO block copolymers of the type described herein as builders. These copolymers may be byproducts of the manufacturing process for the copolyol surfactants. The surfactants and builders used in the compositions of the Examples are listed in Tables 1 and 2.
Table 1- Surfactants Trade Name INCI Name Surfactant Mfr. Mfr. Location Abil B 8852 PEG/PPG-4/12 Goldschmidt Hopewell,VA
Dimethicone Chemical Corp.
Abil B 8873 PEG/PPG-35/65 Goldschmidt Hopewell,VA
Dimethicone 7,000MW Chemical Corp.
Dow 190 Fluid Dimethicone Dow Corning Midland, MI
Z PEG-12 Dimethicone Dow 193 Fluid Hydroxyl terminated, Dow Corning Midland, MI
Lambent MFF-164 Hydroxyl capped Lambent Gurnee, IL
dimethicone copolyol Technologies Inc.
Lambent AD Silicone uaternary 1 Lambent Gumee, IL
Quat Q Technologies Inc.
Silicone Quaternary 2 Lainbent Lambent Quat AM (Myristyl) Technologies Inc. Gumee, IL
Acrylic backbone Lambent Syngard 300 polymer with Lambent Gurnee, IL
dimethylsiloxane Technologies Inc.
sidechains Lambent Wax WS-L Dimethicone copolyol Lambent Gurnee, IL
Laurate Technologies Inc.
Lambent Wax WS-p Silicone Copolyol Lainbent Gurnee, IL
Pelargonate Teclinologies Inc.
Pecosil DCL Dimethicone Copolyol PCI Pheonix Somerville, NJ
Lactate Chemical, Inc.
Sodium Dimethicone PCI Pheonix Pecosil DCT Copolyol Acetyl Somerville, NJ
Methytaurate Chemical, Inc.
Q2-5220 Resin Modifier 3 PEG/PPG- 17/18 Dimethicone Dow Corning Midland, MI
Silicone Copolyol Lambent Silwax WD-IS Isostearate Tecluiologies Inc. Gurnee, IL
PEG Dimethicone, Silwet 77 Methoxy Terininated, GE Silicones Midland, MI
Table 1- Surfactants Trade Name INCI Name Surfactant Mfr. Mfr. Location Silwet L-7001 EO/PO, Methoxy GE Silicones Wilton, CT
terminated 20,000MW
Silwet L-7200 Dimethicone Copolyol GE Silicones Midland, MI
PPO Dimethicone, Silwet L-7500 Butoxy Terminated, GE Silicones Midl4nd, MI
3,000MW
PEG Diinethicone, Silwet L-7602 Methoxy Terminated, GE Silicones Wilton, CT
PEG Dimethicone, Silwet L-7604 Hydroxy Terminated, GE Silicones Midland, MI
PEG Dimethicone, Silwet L-7605 Methoxy Terminated, GE Silicones Wilton, CT
PEG Dimethicone, Silwet L-7614 Hydroxy Terminated, GE Silicones Wilton, CT
3MTn' Silicones "Plus" polysilicone-8 3M Company St. Paul, MN
Polymer VS80 1. Dow 190 surfactant includes poly(ethylene oxide, propylene oxide) monoallyl ether acetate and polyether polyol acetate.
2. Dow 193 surfactant includes polyethylene oxide monoallyl ether.
3. Q2-5220 Resin Modifier includes poly(ethylene oxide, propylene oxide) monoallyl ether acetate; polyethylene glycol monoallyl ether acetate; and polyether polyol acetate.
Table 2 - Foam Builders Trade Name Description Supplier / Mfr. Mfr. Location Aqualon EC K100 Ethylcellulose Hercules Wilmington, DE
PEG-150 Pentaerythrityl Parsippany, Crotliix Liquid tetrastearate (and) PEG-6 Croda NJ
Capric/Caprylic glycerides Economy Ecopol 120-S Hydroxypropyl Guar Polymers and Houston, TX
Chemicals Ganex Butylated Polyvinyl ISP Wayne, NJ
P-904LC Pyrrolidone Technologies Natrosol Plus Cetyl Hercules Wilmington, hydroxyethylcellulose DE
Table 2 - Foam Builders Trade Name Description Supplier / Mfr. Mfr. Location International Plasdone PVP K-120 Polyvinyl Pyrrolidone Specialty Wayne, NJ
Products Phtronic Ethylene Oxide/Propylene BASF Florham Park, F-108 Oxide Block Copolymer NJ
Pluronic Ethylene Oxide/Propylene BASF Florham Park, F-127 Oxide Block Copolymer NJ
Polyox WSR N12K poly(ethylene oxide) Dow Chemical Midland, MI
Ave MW 1,000,000 Co.
Polyox WSR N60K poly(ethylene oxide) Dow Chemical Midland, MI
Ave MW 2,000,000 Co.
Polyox WSR N-80 poly(ethylene oxide) Dow Chemical Midland, MI
Ave MW 200,000 Co.
Polyox WSR-301 poly(ethylene oxide) Dow Chemical Midland, MI
Ave MW 4,000,000 Co.
PVP K-90 Polyvinyl Pyrrolidone (K BASF Florham Park, value 90) NJ
Equipment Foam Pump - A foam pump nozzle was used to generate foanz from each composition.
The pump used was a pump dispenser, product Code F2, type F2-L1 1255/150, available from Airspray International Inc. of North Pompano Beach, FL.
Foam Collection vial - Vials were used to collect foam from the pump dispenser while the foam height was being measured. The vials were made of glass and were of either 40 or 80 nun height having a 25mm internal diameter and a 27mm outer diameter.
Test Methods Foam I-Ieight Test Procedure The Foam Pump was used to assess the foam forming property of the compositions. The pump was rinsed between samples with deionized water by pumping water through the pump until it ccune out clear. The pump dip tube was removed from the water and then pumped dry of residual water and then placed in the coinposition to be tested.
The pump was then pumped 3 times to prime the pump and then 3 more times to purge solution through the nozzle to ensure the system was ready. Finally, three pumps worth of foam were collected in a collection vial by pumping slowly at a speed of about 1 second for each pump. The vial containing the foam was placed on a flat surface, a timer was started and a small ruler witll millimeter increments was used to measure the approximate height of the foam, ignoring the height of any remaining unfoamed composition. The time to measure the foam height usually took about 5 seconds. Any composition producing a foam which was not stable at least 5 seconds was considered unstable and rated 0 mm. The foam height was estimated to be the average height of the foam. A rating of 0 mm was given if the top of the solution was void of foam in any spot, usually the center. The foam height was recorded after 1, 3 and 5 minutes to determine the long term stability of the foam.
Foam Volume % Increase The percentage of foam volume increase over the solution volume was calculated by measuring the foain heigllt in millimeters, subtracting 5mm from the foam height and dividing the result by 5 (the volume of the un-foamed pumped solution) and multiplying by 100%. Foam voluine % increase measurements were made immediately following creation of the foam (e.g., after dispensing). Due to the difficulty in determining the exact foam surface, foain heights between 0-5 mm were reported as having a zero percent increase in foain volume.
Viscosity Viscosity in centipoise (cP) was measured at 23 C at ambient pressure using a Brookfield viscometer Model LVT equipped with a Brookfield LV spindle # 1@ 60 rpm. All samples were allowed to equilibrate at 23 C for 24 hours prior to measurement.
The viscosity was taken at the lowest speed possible while staying within 10-100%
of the viscometer range and more preferably between 20-80% of the range. The viscosity was read after one minute of testing. In all cases the sample size and container geometry was chosen to ensure that there were no wall effects. By "wall effects" it is meant the viscosity value is not affected by the container and is essentially equivalent to the viscosity taken in an infinitely large container. For this reason lower viscosity sainples required a larger sample size to accoininodate the larger spindles.
Examples 1-13 Examples 1-13 were prepared using various amounts of the surfactant Dow 190;
plus a poly(ethylene oxide) (PEO) foam builder, available from Dow Chemical Company of Midland, MI, under the trade name POLYOX(TM) WSR N12K; distilled water, and an alcohol solvent. Foam heiglit measurements according to the above test method were taken for each saniple. The foam height measurements and formulations for each of the Examples are set forth in Table 3.
Dow 190 Foam Water SDAI Initial Foam Foam Foam BuilderN z Foam Height Height Height Example Sarf~ 12K Amt. (EtOH/ Il'A Height 1 min. 3 min. 5 min.
Amt. /~ Amt. % % IPA) mm mm mm mm 1 1.00 0.060 43.94 55.00 - 32 30 24 23 2 1.00 0.060 38.94 60.00 - 32 29 28 22 3 1.00 0.060 35.17 63.77 - 35 33 29 20 4 1.00 0.060 28.94 70.00 - 34 32 26 18 5 1.00 0.060 23.94 75.00 - 28 26 21 17 6 1.00 0.060 18.94 80.00 - 30 29 23 14 7 1.00 0.060 43.94 - 55.00 36 35 32 28 8 1.00 0.060 34.94 - 64.00 35 33 29 23 9 0.50 0.060 35.44 - 64.00 25 23 20 14 10 1.00 0.060 23.94 - 75.00 17 5 1 0 11 1.00 0.060 18.94 80.00 - 35 32 25 16 12 1.00 0.060 8.94 90.00 - 27 23 14 8 13 1.00 0.060 34.94 0.00 64.00 26 25 21 14 1. SDA is Specially Denatured Alcohol (SDA-3-C): a mixture of 100 parts USP
200 proof Ethanol plus 5 parts isopropy] alcohol (IPA).
2. IPA is isopropyl alcohol, reagent grade.
3. n-propanol (reagent grade) was used instead of isopropyl alcohol.
Examples 14-32 Examples 14-32 were all prepared with the same alcohol solvent, foam builder, surfactant and water content. The only variation in Examples 14-32 was the type of surfactant used.
The alcohol solvent was SDA-3-C and was present at 64.00%; the foam builder was PEO
N12K (listed above) and was present at 0.06 %; the water content was 25.50%
and the amount of surfactant was 2.50%. Foam height data and foan'i volume % increased data are reported in Table 4 for each of the compositions.
Table 4 Initial Foam Foam Foam Foam Foam Height Height Height Volume Height 1 min. 3 min. 5 min. %
Example Surfact.Trade Name mm mm mm Mm Increase 14 Dow 190 Fluid 45 42 28 12 800%
The present invention relates to foamable alcohol compositions, systems for dispensing the compositions and methods for the use of the compositions.
Background Foamable soap products contain a significant quantity of air. While these compositions can be economically manufactured as compared with non-foamable compositions, the formulation of foainable compositions comprising a high alcohol content has generally required the compositions to be provided as aerosol products which include a propellant (e.g., hydrocarbon, fluorocarbon, compressed gas) to facilitate foaming when the composition is dispensed from an aerosol container. These aerosol compositions can also include polymeric gelling agents, moderately high molecular weight (e.g., C16 to C22) alcohols and nonionic surfactants, for example. Aerosol products are costly to manufacture because of the need for a pressurized container and the inclusion of a foaming propellant.
In the formulation of non-aerosol soap products having a high alcohol content, surfactants have been included in such compositions to facilitate some level of foaming when the compositions are dispensed through a mechanical pump or the like. Surfactants can facilitate at least some degree of initial foaming, but such non-aerosol foams are often unstable and tend to collapse as soon as they are dispensed. While some fluorochemical surfactants have been known to facilitate more stable foams in non-aerosol compositions, fluorochemical surfactants may raise environmental concerns.
There is a need to provide foainable alcohol-containing compositions that are formulated to be anti-microbial and which can be applied to the skin (e.g., the hands).
There is a need for alcohol-containing compositions that will forin a stable foam in the absence of an aerosol propellant and which will deliver alcohol to the skin for rapid skin disinfection.
Within the foregoing need, it is desirable to provide foamable, low viscosity, alcohol-containing compositions that are safe and efficacious while providing properties that may be desired by tlie consumer.
Summary In one aspect, the present invention provides a composition, comprising:
(A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity;
(B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.
In another aspect, the invention provides a system comprising a container and the composition as described above, the composition contained within the container under pressure and a propellant present within the composition.
In still another aspect, the invention provides a system comprising a dispenser comprising a reservoir and a hand pump; and the composition as described above contained within the reservoir.
In still another aspect, the invention provides a skin sanitizer comprising the composition as described above.
In still another aspect, the invention provides a pre-surgical hand scrub comprising the composition as described above.
In still another aspect, the invention provides a method for sanitizing a surface, comprising applying a volume of the composition as described above to the surface, the composition being in the form of a stable foam.
It will be appreciated that the terms used herein will be understood as being defined according to the understanding of those skilled in the art at the time of the present invention. However, certain terms used herein shall be understood as having the meaning that is expressly set forth herein:
"Builder" refers to a material that can be incorporated as a component in the compositions of the invention to aid in the creation of a stable foam when the composition is dispensed from an aerosol or a non-aerosol dispenser. Compositions comprising a builder can produce lower foam densities (greater volume) as compared to the same volume of the composition in the absence of the builder.
"Emollient" as used herein refers broadly to materials which are capable of maintaining or improving the moisture level, compliance, or appearance of the skin.
"Foam" refers to a frothy mass of bubbles formed on or from a liquid (e.g., the compositions of the invention).
"HLB" means the "hydrophile-liphophile balance," or the balance between the oil soluble and water soluble moieties in a surface active molecule or surfactant.
"Polymer" as used herein refers to a natural or synthetic molecule having repetitive units and a number average molecular weight of at least 20,000.
As used herein, "poly(propylene oxide)" and "poly(ethylene oxide)" are intended to be syiionymous with "polypropylene glycol" or "PPG" and "polyethylene glycol" or "PEG,"
respectively. Poly(propylene oxide) and poly(ethylene oxide) are also abbreviated herein as "PPO" and "PEO," respectively.
"Solvent", "solvent system" or "hydroalcoholic solvent" as used herein refer to the alcohol and water combination in the present invention.
"Stable," as used when referring to a foamed composition, refers to foam that maintains a measurable height for a period of time of at least about 5 seconds following creation of the foam (e.g., by shaking the composition or by dispensing the composition from an aerosol or non-aerosol dispenser at ambient temperature). The stability of a particular foam may further be expressed in terms of the height of the foam after a measured period of time (e.g., 6 mm after 1 minute). Foam height measurements are further discussed in the Examples.
Those skilled in the art will more fully understand the various features and aspect of the invention upon consideration of the remainder of the disclosure, including the Detailed Description, the Examples and the appended claims.
Detailed Description The invention provides a foamable composition coinprised of alcohol, surfactant and builder. The compositions of the invention may be aqueous compositions.
Optional ingredients such as antimicrobials and/or emollients, for example, may be included to provide or enhance the properties of the compositions. The compositions of the invention provide the benefits of a foam for the disinfection of skin by providing a coinposition with a sheer thinning viscosity that is better than that for gelled compositions and which can be more easily rubbed onto sensitive tissue. Additionally, the compositions of the invention generally will dry quicker than a gel following application to a surface such as the hands, for example.
Alcohol The compositions of the invention will include at least one alcohol that provides the ability to rapidly kill a broad spectrum of microbes. The compositions of the invention are suitable for use on the skin or other surfaces and may be used as a disinfectant for the hands, for exainple. In embodiments of the invention, the alcohol or alcohols are monohydric alcohols. Typically, the compositions of the invention comprise alcohols having lower hydrocarbon chain lengths such as C2 to C4 alcohols. In some embodiments, the compositions of the invention comprise a single alcohol. In other embodiments, a blend of two or more alcohols may be present. In some embodiments, the alcohol will consist of ethanol. In still other embodiments, the alcohol will consist of propanol (e.g., n-propanol and/or isopropanol). In still other embodiments, the alcohol will consist of butanol (e.g., n-butanol, sec-butanol and tert-butanol). In some embodiments the alcohol is dissolved in water to provide an alcohol-water solvent.
Embodiments of the invention may comprise compositions having an alcohol content between about 35% and about 99.5% by weight. In some embodiments, the compositions of the invention will have an alcohol content within the range from about 60%
to about 80%. Compositions having an alcohol content within the foregoing ranges typically provide an efficacious bacterial kill.
Surfactants At least one surfactant is present in the compositions of the invention. In some embodiments, surfactant may be present in the coinpositions of the invention at concentration ranges from about 0.1 % to about 10% by weight, based on the total weight of the composition. In some embodiments, the surfactant may be present in a composition at a concentration ranging from about 0.5% to about 5% by weight, based on the total weight of the composition. Those skilled in the art will appreciate that certain surfactants may impart a tacky or even a greasy feel to a composition when the surfactant concentration is greater than 5% by weight. While such surfactant concentrations are contemplated as within the scope of the invention, the skilled artisan may wish to consider the cosmetic effects of surfactant concentrations when formulating a composition for use by the consumer. In some embodiments, the compositions of the invention are formulated with non-fluorinated surfactants and without the need for fluorochemical propellants.
Specific surfactants useftil in the invention include dimethicone surfactants.
Examples of dimethicone surfactants include dimethicone copolyols - a polymer of dimethylsiloxane with polyoxyethylene (PEO) and/or polyoxypropylene (PPO) side chains. In some embodiments, these surfactants can be hydroxyl, methoxy or butoxy terminated, and the molar ratio of PEO to PPO (PEO/PPO) can range from 0/50 to 50/0 and the molecular weight of the dimethicone portion can range from 200 to 20,000. The surfactants used in the invention can comprise specific dimethicone surfactants. Specific surfactants suitable for use in embodiments of the invention include, without limitation, methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 3000;
dimethicone with a pendant ether of 35/65 (w/w) polyethylene glycol /
polypropylene glycol copolymer having a combined average molecular weight of about 7,000;
dimethicone copolyol witll 18/18 (molar ratio) polyethylene glycol /
polypropylene glycol;
a diinethicone copolyol with 17/18 (molar ratio) polyethylene glycol /
polypropylene glycol; a dimethicone copolyol with polyethylene glycol / polypropylene glycol - methoxy terminated having an average molecular weight of about 20,000 and a HLB of 9-12;
dimethicone copolyol witli a methoxy- terminated polyethylene glycol having a combined average molecular weight of about 3000; dimethicone copolyol with a methoxy-terminated polyethylene glycol having a combined average molecular weight of about 6000; dimethicone copolyol with a hydroxy terminated polyethylene glycol having a combined average molecular weight of about 5000 with an HLB of 13-17;
dimethicone copolyol lactate; silicone copolyol pelargonate; hydroxyl-capped dimethicone copolyol;
hydroxyl-terminated polyethylene glycol- 12 dimethicone; dimethicone copolyol laurate;
Silicone Quaternary 1; hydroxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 4000; methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 600; Silicone Quaternary 2 (Myristyl); sodium dimethicone copolyol acetyl methyltaurate; butoxy-terminated poly(propylene oxide) dimetllicone having an average molecular weight of about 3,000;
and silicone copolyol isostearate.
Additionally, the following surfactants may be usefi,il in the invention:
dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethocone copolyol almondate, dimethicone copolyolamine, dimethicone copolyol avocadoate, dimethicone copolyol beeswax, dimethicone copolyol behenate, dimethicone copolyol benzoate, dimethicone copolyol bishydroxy ethylamine, dimethicone copolyol borageate, dimethicone copolyol butyl ether, dimethicone copolyol cocoa butterate, dimethicone copolyol crosspolymer, dimethicone copolyol dhupa butterate, dimethicone copolyol ethyl etlier, dimethicone copolyol hydroxy stearate, dimethicone copolyol isostearate, dimethicone copolyol kokum butterate, dimethicone copolyol lactate, diinetllicone copolyol laurate, dimethicone copolyol mango butterate, dimethicone copolyol meadowfoamate, dimethicone copolyol methyl ether, dimethicone copolyol mohwa butterate, dimethicone copolyol octyldodecyl citrate, dimethicone copolyol olivate, dimethicone copolyol phosphate, dimethicone copolyol phthalate, dimethicone copolyol sal butterate, dimethicone copolyol shea butterate, dimethicone copolyol stearate, dimethicone copolyol undecylenate, dimethicone hydroxypropyl trimonium chloride, dimethicone propyl pg-betaine, polysilicone-10, polysilicone-8, dimethcone propylethylenediamine behenate, amino bispropyl dimethicone aminoethylaminopropyl dimethicone, behentrimonium dimethicone copolyol phthalate, bis-aminopropyl copolyol aininopropyl dimethicone, bis-hydroxyethoxypropyl dimethicone, cetyl triethylmonium dimethicone copolyol succinate, dimethicone copolyol sulfate, dimethicone copolyol phosphate, dimethicone polyglycerol, disodium copolyol dimethicone sul'fosuccinate, copolyol polydimethylsiloxyethyl dimethicone, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, copolyol oleyl ether dimethicone, sodium carboxydecyl copolyol dimethicone.
Combinations of two or more of the foregoing dimethicone surfactants in a single composition are also contemplated within the scope of the invention Builder At least one builder may be included in the compositions of the invention in order to stabilize the foams produced from the compositions when the coinpositions are shaken, or when they are dispensed from either an aerosol or a non-aerosol dispenser. In some embodiments, the inclusion of certain builders can provide cosmetic attributes to the compositions of the invention. Suitable builders can include one or more of the following:
poly(ethylene oxide), hydroxyethyl cellulose, hydroxypropyl cellulose. In some embodiments, the builder will comprise only one of the foregoing. In other embodinients, the builder will comprise a combination of two or more of the foregoing builder. In some embodiments, the builder will coinprise a poly(ethylene oxide) having an average molecular weight in the range from about 200,000 to about 4,000,000. One poly(ethylene oxide) suitable for use in the compositions of the invention is that know under the designation POLYOXTM and commercially available from Dow Chemical Canada Inc., Sarnia, Ontario. Suitable POLYOX compositions include those designated as "WSR
N12K" having an average molecular weight of 1,000,000; "WSR-301" having an average molecular weight of 4,000,000; "WSR N60K" having an average molecular weight of 2,000,000; and "WSR N-80" having an average molecular weight of 200,000.
The builder, when included in the compositions of the invention, may be present at concentrations less than or equal to about 0.1%. In some embodiments, the builder is present in the coinposition at concentrations of about 0.06%.
In general, the builder enhances the stability of the foam produced when the composition of the invention is shalcen or when the composition is dispensed. Builders suitable for use in the invention will include those that provide or enhance the stability of the foam - i.e., those that provide a measurable foam height over at least about 5 seconds following the creation of the foam. In some embodiments, the builder is soluble in the alcohol that is used in the compositions of the invention. In some embodiments, the builder will be swellable within the alcohol. In still other embodiments, the builder can be characterized as dispersible in the aleohol.
In some embodiments, suitable foam builders include compounds comprising high molecular weight polymers. In some embodiments, these polymers are alcohol or hydroalcoholic soluble. Specific polymers useful in the invention include, without limitation: Poly(ethylene oxide) (molecular wt of 100,000 to 10,000,000), high molecular weight polyetliylene - polypropylene copolymers, hydroxyethyl cellulose, hydroxypropyl cellulose. When present, the polymer will be at a concentration of between about 0.001 and about 5%. In some embodiments, the polymer concentration will be between about 0.01 % and about 0.5%.
Polymers within the following classes can be useftil as builders in the compositions of the invention: hydroxypropyl guar, polyquaternium-4, polyquaternium-10, cetyl hydroxyethylcellulose, ethylhydroxy ethyl cellulose, polyglycerol, high molecular wt.
polyoxamer, high molecular wt. polyoxamine, polyacrylamide, high molecular wt polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-l to polyquaternium-47, polyvinyl methyl ether, butylated poly vinyl pyrrolidone, hydroxypropyl methylcellulose; hydroxypropyl cellulose;
crosslinked and nonerosslinlced homopolyiner or crosslinlced and noncrosslinlced copolymer containing n-vinyl lactam monomeric units.
Non-limiting examples of N-vinyl lactam monomers are N-vinyl-2-pyrrolidone; N-vinyl-2-valerolactam; N-vinyl-2-caprolactam; and mixtures of any of the foregoing.
Typically, the poly(N-vinyl lactain) is a homopolymer of N-vinyl-2-pyrrolidone.
Nonlimiting examples of comonomers useful with the aforementioned N-vinyl lactam monomers include N,N-dimethylacrylarnide, acrylic acid, methacrylic acid, hydroxyethylmethacrylate, acrylamide, 2-acrylamido-2-methyl-l-propane sulfonic acid or its salt, and vinyl acetate.
While the foregoing builders can be added to the compositions of the invention individually, combinations of two or more such builders are also contemplated within the scope of the invention as well as derivatives thereof.
Viscosity of Compositions The compositions of the invention will typically be of very low viscosities at 23 C. In some embodiments, the compositions of the invention can have different viscosities depending on the state of the composition. For example, a composition in a pre-dispensed condition, i.e., it is in a "pre-foamed" state in a dispenser prior to being dispensed, can have a viscosity within the range from about 0.5 to about 100 cps at 23 C. In some embodiments, the prefoam viscosities of compositions of the invention will range from about 0.5 cps to about 50 cps. In still other embodiments, the prefoam viscosities of compositions of the invention will range fiom about 0.5 cps to about 20 cps.
When a composition of the invention is dispensed from a non-aerosol pump-type dispenser, the composition will foam, and the foam will typically be of a higher viscosity than the viscosity of the liquid "non-foamed"composition prior to dispensing. It will also be appreciated that the addition of an emollient and/or other optional ingredients (discussed herein) can also have an affect on viscosity (either positively or negatively).
Foam Density The compositions of the invention will foam when shaken of dispensed from a dispenser.
It will be appreciated that the foam densities of the compositions can vary depending on any of a variety of factors. For example, the viscosity of the unfoamed composition, discussed above, can have an effect on foam density. Moreover, the design of the dispenser or the non-aerosol pump used to deliver the foamed composition can have an effect on the foam density of the composition to the extent that the dispenser and/or the pump effect the foaining of the composition. Additionally, the amount of force applied to the pump and the relative speed at which the pump is operated when dispensing the composition can also have an effect on the foaming of the composition and its resulting viscosity.
Optional Ingredients In addition to alcohol-water, surfactant and builder, the compositions of the present invention may optionally include other ingredients such as salts, emollients, stabilizers, antimicrobials, fragrances, therapeutic agents, propellants and additional emulsifiers.
Each of these optional ingredients along with the effect each has upon the properties of the final composition is discussed below.
Emollients can optionally be added to the compositions of the invention so that the compositions can be provided in a form that is capable of increasing the moisture content of the stratum corneum wlien the composition is applied to a user's hands, for example.
Emollients are generally separated into two broad classes based on their function. The first class of emollients fttnction by forming an occlusive barrier to prevent water evaporation from the stratum corneum. The second class of emollients penetrate into the stratum corneum and physically bind water to prevent evaporation. The first class of emollients is subdivided into compounds which are waxes at room temperature and compounds which are liquid oils. The second class of emollients includes those which are water soluble and are often referred to as humectants.
As referred to herein, the alcohol-water, surfactant and builder components used in the compositions of the invention are separate and distinct from components identified as emollients and optionally added to the composition. Emollients may be added to the compositions in addition to the aforementioned silicone block surfactants and builder compounds which may also aid in maintaining or improving the skin condition of the user.
In some embodiments, added emollients may be included the compositions of the invention at a concentration between about 0 and about 30% by weight. In some embodiments, the added emollient can be present in the composition at a concentration between about 0.5% and about 20%. In still other embodiments, the emollient concentration can be between about 1% and about 12% by weight. Suitable emollients may be selected from any of the classes lcnown in the art. A general list of useful emollients appears, for example, in U.S. Patent No. 4,478,853 and in EPO
patent application 0 522 624A1 as well as in the CTFA Cosmetic Ingredient Handbook published by The Cosmetic, Toiletry, and Fragrance Association, Wash. D.C. (1992) under the listings "Skin Conditioning agents," "emollients," "humectants,"
"miscellaneous" and "occlusive."
In some embodiments, suitable emollients may be chosen from the following nonlimiting list of general emollients, occlusive emollients and humectants. Examples of general emollients include short chain alkyl or aryl esters (CI -C6) of long chain straight or branched chain alkyl or allcenyl alcohols or acids (C8-C32) and their polyethoxylated derivatives; short chain alkyl or aryl ester (C I -C6) of C4-C12 diacids or diols optionally substituted in available positions by -OH; alkyl or aryl C1-Clo esters of glycerol, pentaerythritol, etliylene glycol, propylene glycol, as well as polyethoxylated derivatives of these and polyethylene glycol; C12-C22 allcyl esters or ethers of polypropylene; C12-C22 alkyl esters or ethers of polypropylene/polyethylene glycol copolymer.
Examples of occlusive emollients include cyclic and linear dimethicones;
polydialkylsiloxanes; polyaryialkylsiloxanes; long chain (Cg-C36) alkyl and alkenyl esters of long straight or branched chain alkyl or alkenyl alcohols or acids; long chain (C8-C36) alkyl and alkenyl amides of long straight or branched chain (Cg-C36) alkyl or alkenyl amines or acids; hydrocarbons including straight and branched chain alkanes and alkenes such as squalene, squalane and mineral oil; jojoba oil; polysiloxane polyalkylene copolymers; shoi-t chain alkyl or aryl esters (CI-C36) of C12-C22 diacids or diols optionally substituted in available positions by OH such as diisopropyl dimer dilinoleate; and C12-C22 alkyl and alkenyl alcohols; long chain alkyl or aryl esters (C8-C36) of C12-C22 diacides or diols optionally substituted in available positions by -OH, such as diisostearyl dimer dilinoleate; lanolin and lanolin derivatives; and beeswax and.its derivatives.
Non-limiting examples of preferred humectant type emollients include glycerol, polyglycerols (including: diglycerol, triglycerol, polyglycerin-3, tetraglycerol, hexaglycerol, decaglycerols) propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol (PEG-2 to PEG-45M, preferably a molecular weight between about 300 and 1,000), sorbitol, polyhydric alcohol ethoxylates (e.g. sorbeth-6, sorbeth-30, glycereth-1 to glycereth-3 1) methoxides of polyethylene glycol (Methoxy PEG-2 to Methoxy PEG-100) methoxides of polyhydric alcohol ethoxylates (e.g. glycereth-methoxide), pantothenol, gluconic acid salts and the like. Other huinectant-type agents like that could also be employed include: 1,2,6-hexanetriol, acetamide mea, aluminum hydroxide, arginine pea, butoxypropanol, butylene glycol, dimethyl imidazolidinone, dimethylsilanol hyaluronate, dipotassium glycyrrhizate, erythritol, ethoxy-diglycol, fructose, glucainine, gluconic acid, glucose, glucose glutamate, glucuronic acid, glutamic acid, glycogen, glycyrrhizic acid, heilmoor clay, hexacosyl glycol, histidine, hyaluronic acid, hydrogenated honey, hydrogenated starch, hydrolysate,liydrolyzed collagen, hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydrolyzed keratin, hydrolyzed silk, hydrolyzed soy protein, hydrolyzed wheat protein, hydroxyethyl sorbitol, inositol, inositol hexa-pea, lactamide mea, lactic acid, lactitol, lactose, lysine pea, magnesium pea, maltitol, manganese pea, mamiitol, mel (honey extract), menthyl pea, methyl gluceth-10, methyl gluceth-20, pea (pidolic acid), lactainide, polydextrose, polyglucuronic acid, polyglyceryl sorbitol, potassiuin pea, ppg-20 methyl glucose ether, ppg-38-buteth-37, saccharide isomerate, serica, silk amino acids, sodium carboxymethyl chitin, sodium lactate, sodium mannuronate methylsilanol, sodium pea, sodium pea methylsilanol, sodium polyglutamate, soluble collagen, sorbitol, sucrose, tea-lactate, tea-pea, trehalose, trilactin, urea, xylitol, zea mays, zinc pea, and combinations thereof.
The addition of one or more emollients may affect the viscosity and stability of the compositions of the present invention. In some embodiments, a single emollient may be added to the coinposition. hi some embodiments, two or more emollients may be added to the composition. While any of a variety of emollients may be added to the formulations of the present invention, some embodiments will include wax and oil type emollients either alone or combined with water soluble emollients. In some embodiments of the invention, emollient systems can be coinprised of humectants in addition to occlusive wax and oil emollients in concentrations that achieve a moisturizing effect and which maintains and improves the condition of the skin upon repeated use. Emollierits may be non-comedogenic and chosen to avoid skin irritation or sensitization reactions.
In addition to the antimicrobial effects attributable to the presence of alcohol in the compositions of the present invention, one or more other antimicrobial agents ("secondary antimicrobial agents") may be added to enhance the antimicrobial properties of the compositions when they are used as pre-surgical hand scrubs or pre-surgical patient skin scrub replacements, for example. In other words, the foamed composition of the present invention can deliver a secondary antimicrobial agent to the skin. In some embodiments, the secondary antimicrobial agent is added in levels up to 10% by weight of the total composition. In some embodiments, it may be desirable to incorporate a secondary antimicrobial agent in the compositions of the invention to provide continued antimicrobial resistance to the growth or regrowth of the microorganisms following evaporation of the alcohol.
Non-limiting exainples of suitable secondary antimicrobial agents include parachlorometaxylenol; triclosan; chlorhexidine and its salts such as chlorhexidine gluconate, poly hexamethylene biguanide and its salts such as poly hexamethylene biguanidine chloride, iodine, idodophors; fatty acid monoesters; poly-n-vinyl pyrrolidone-iodophors; silver oxide, silver and its salts, peroxides (e.g. hydrogen peroxide), antibiotics (e.g. neomycin, bacitracin, and polymixin B).
Additionally, other suitable ingredients can be used in the compositions of the invention to suppress the regrowtli or possibly treat an infection of microorganisms, such as: 2,2-thiobis(4-chlorophenol); 4,4-isopropylidenediphenol; 5-amino-6-chloro-o-cresol;
acetaminosalol; alcloxa; aldioxa; aluminum acetate; aluminum benzoate;
aluminum diacetate; aluininum formate; aluminum phenolsulfonate; ammonium iodide;
ammonium phenolsulfonate; benzisothiazolinone; benzotriazole; benzoxiquine;
benzylparaben;
berberine chloride; boric acid; cetethyl morpholinium ethosulfate;
cetethyldimonium bromide; cetrimonium tosylate; cetylpyridinium chloride; chloramine-t;
chlorothymol;
cloflucarban; cocotrimonium chloride; colloidal sulfur; copper usnate;
dedmhydantoin;
dedm hydantoin dilaurate; dequalinium acetate; dequalinium chloride;
dibromopropamidine diisethionate; dichloro-m-xylenol; dichlorophene;
dichlorophenyl imidazoldiox6lan; diiodomethyltolylsulfone; dimethyl hydroxymethyl pyrazole;
dimethylaminostyryl heptyl methyl thiazolium iodide; dodecylbenzyltrimonium chloride;
domiphen bromide; ferulic acid; fluorosalan; glyoxal; hydroxymethyl dioxoazabicyclooctane; lzydroxypropyl bistrimonium diiodide; ichthammol;
isodecylparaben; isopropyl sorbate; lapyrium chloride; laurtrimonium trichlorophenoxide;
lauryl iso-quinolinium bromide; lauryl isoquinolinium saccharinate;
laurylpyridinium chloride; m-cresol; mandelic acid; MDM hydantoin; MEAa-iodine; melaleuca alternifolia;
methyl-benzethonium chloride; mixed cresols; nonoxynol-12 iodine; nonoxynol-9 iodine;
o-cresol; oxyquinoline benzoate; oxyquinoline sulfate; p-chlorophenol; p-cresol; PEG15 dedm hydantoin; PEG-15 dedm hydantoin stearate; PEG-5 dedm hydantoin; PEG-5 dedm hydantoin oleate; phenol; phenoxyethylparaben; phenyl salicylate; polymethoxy bicyclic oxazolidine; potassium iodide; potassium lactate; potassium phenoxide;
potassium troclosene; quartronium-14; quaternium-24; quaternium-8;
ricinoleamidopropyltrimonium methosulfate; sodium iodide; sodium p-chloro-m-cresol; sodiuin phenolsulfonate; sodium phenoxide; sodium usnate; steapyrium chloride; strontium peroxide; tea-sorbate; tetrabutyl ammonium bromide; thiabendazole; triacetin; undecylenamide dea; undecylenamide mea;
undecylenamidopropyltrimonium methosulfate; tuidecyleneth-6; undecylenoyl peg-paraben; usnic acid; zinc acetate; zinc borate; zinc phenolsulfonate; zinc sulfate; zinc undecylenate; and coinbinations of the foregoing.
The following actives could also be of use to also reduce regrowth of microorganisms on skin: 2-bromo-2-nitropropane- 1,3 -dial; 4-hydroxybenzoic acid; 5-bromo-5-nitro-1,3-dioxane; 7-ethylbicyclooxazolidine; ammonium benzoate; ammonium bisulfite;
ammonium propionate; ammonium sulfite; behentrimonium chloride; benzalkonium bromide; benzallconium chloride; benzalkonium saccharinate; benzethonium chloride;
benzoic acid; benzyl alcohol; benzylhemiformal; bromochiorophene; butyl benzoate;
butylparaben; calcium benzoate; calcium paraben; calcium propionate; calcium salicylate;
calcium sorbate; calcium undecylenate; cetalkonium chloride; cetearalkonium bromide;
cetrimonium bromide; cetrimonium chloride; chloroacetamide; chlorobutanol;
chlorophene; chloroxylenol; chlorphenesin; climbazole; dehydroacetic acid;
diazolidinyl urea; dibromohexamidine isethionate; dichlorobenzyl alcohol; dimethyl oxazolidine;
DMDM hydantoin; ethyl benzoate; ethylparaben; formaldehyde; formic acid;
glutaral;
hexamidine; hexamidine diisethionate; hexamidine paraben; hexetidine;
hydrogenated tallowtrimonium chloride; iinidazolidinyl urea; iodopropynyl butylcarbamate;
isobutyl benzoate; isobutylparaben; isopropyl benzoate; isopropyl cresols;
isopropylparaben;
lauralkonium bromide; lauralkonium chloride; laurtrimonium bromide;
laurtrimonium chloride; magnesium benzoate; magnesium propionate; magnesium salicylate; MEA
o-phenylphenate; MEA-benzoate; MEA-salicylate; MEA-undecylenate; methenamine;
methyl benzoate; methylchloroisothiazolinone; methyldibromo glutaronitrile;
methylisothiazolinone; methylparaben; myristalkonium chloride; myristalkonium saccharinate; myrtrimonium bromide; o-cymen-5-01; o-phenylphenol; olealkonium chloride; p-chloro-m-cresol; phenoxyethanol; phenoxyisopropanol; phenyl benzoate;
phenyl mercuric acetate; phenyl mercuric benzoate; phenyl mercuric borate;
phenyl mercuric bromide; phenyl mercuric chloride; phenylparaben; piroctone olamine;
polyaminopropyl biguanide; potassium benzoate; potassium butylparaben;
potassium ethylparaben; potassium metabisulfite; potassium methylparaben; potassium o-phenylphenate; potassium paraben; potassium propionate; potassium propylparaben;
potassium salicylate; potassium sorbate; potassium sulfite; propionic acid;
propyl benzoate; propylparaben; quaternium-15; salicylic acid; sodium benzoate;
sodium bisulfite; sodium butylparaben; sodium dehydroacetate; sodium ethylparaben;
sodium formate; sodium hydroxyinethylglycinate; sodium iodate; sodium metabisulfite;
sodium methylparaben; sodium o-phenylphenate; sodium paraben; sodium propionate;
sodium propylparaben; sodium salicylate; sodium sorbate; sodium sulfite; sodium undecylenate;
sorbic acid; soytrimonium chloride; stearalkonium chloride; steartrimonium chloride;
tallowalkonium chloride; tallowtrimonium chloride; thimerosal; triclocarban;
triclosan;
undecylenic acid; zinc pyrithione.
The present invention further encompasses embodiments incorporating antimicrobials such as benzoyl peroxide so that the composition may be useful as an acne medication, for example. In some embodiments, the compositions of the present invention may also be formulated with barrier compounds to form barrier creams and lotions.
Materials which may be added to provide barrier protection for use as skin barriers to protect against diaper rash include but are not limited to 0.1 to 60% aldioxa, allantoin, aluininum acetate, aluminum hydroxide, bisinuth subnitrate, boric acid, calamine, cellulose (microporous), cholecalciferol, cocoa butter, cod liver oil (in combination), colloidal oatmeal, cysteine hydrochloride, dexpantllenol, dimethicone, glycerin kaolin, lanolin (in combination), live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsain oil, pertrolatum, protein hydrolysate (1-leucine, 1-isoleucine, 1-methionine, 1-phenylalanine, and 1-tyrosine), racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate and zinc oxide.
In some embodiments, the compositions of the invention may comprise one or more formulations containing antifiingal agents for the treatment of fiingal infections of the skin such as athlete's foot and the like.
While some embodiments will include one additional secondary antimicrobial agent, other embodiments of the invention can include two or inore additional secondary antimicrobials. While the foregoing secondary antimicrobials can be added to the compositions individually or singly, combinations of two or more of the foregoing secondary antiinicrobials are also contemplated within the scope of the invention.
In some embodiments, the compositions of the present invention may be formulated into non-aerosol products that can be dispensed from a reservoir using a hand-pump, for example, to dispense an amount of the composition whenever the hand pump is actuated.
The amount of the composition dispensed by the pump may or may not be metered so that the amount of composition dispensed may or may not be consistent. Moreover, the compositions of the invention are not limited to being dispensed from only one type of dispenser or through only one type of hand pump.
In some embodiments, the compositions are capable of being forinulated into an aerosol foam or a mousse by addition of propellant to the composition. Suitable propellants can be chosen from chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorinated alkanes, and lower alkanes (C1- C5) as well as nitrous oxide diinethyl ether and other solvent-soluble propellants. Suitable lower alkanes include propane, butane, and isobutane, for example. In some embodiments, the propellant can comprise a 70/30 mixture of propane/isobutane. In order to produce an aerosol composition the composition is first forinulated and charged into an appropriate pressure rated container. A suitable propellant may then be added to the composition under pressure at approximately 2-30% preferably 3-20% by volume. The propellant may form a separate layer on the composition or the propellant may be emulsified or miscible in the composition.
The compositions of the invention can be used in any of a variety of applications including use as a sanitizer for application to a surface. The compositions of the invention are suitable for use on mammalian skin including the human hands. In some embodiments, the compositions may be used as a pre-surgical hand scrub. In non-aerosol formulations of the invention, the compositions may be contained in a non-aerosol dispenser equipped with a conventional hand ptunp, and the composition may be pumped onto the hands or other areas of the body. The purnping action required to dispense the compositions will create a discrete volume of a dispensed coinposition in the form of a stable foam.
Lilcewise, in embodiments comprising an aerosol, the aerosol formulation may be dispensed fi-om a pressurized container in a discrete volume of foamed composition. After dispensing, the foazn inay be spread upon the si.trface of the slcin to sanitize the skin, the hands or the like. While some residue may remain on the skin following evaporation of the alcohol coinponent, the residue can comprise emollients or the like to provide a desired cosmetic effect. Consequently, the compositions of the invention provide a means for sanitizing skin in the form of a foamable composition which does not need to be rinsed from the skin following application of the foam to the area in need of sanitization.
Alternatively, undesired residue remaining on the surface can be rinsed off with water, for example.
From the foregoing, it will be appreciated that the present invention also encompasses systems for dispensing the coinpositions comprising a reservoir and an amount of composition retained therein, and means for dispensing the composition from the reservoir.
The coinpositions of the present invention may be prepared by a variety of techniques and the ingredients may be added to one another in any order of addition. To ensure a composition of maximum stability, the components may be subjected to high shear (e.g.
homogenized) for a limited time period.
EXAMPLES
The following non-limiting Examples are provided to illustrate features of the invention.
are not intended to limit the scope of the invention. All percent amounts are weight/weight percent (wt/wt%) unless otherwise noted.
Preparation of Compositions The coinpositions in the Examples were prepared in 60 gram samples by combining all components in a glass jar and rolling the jar overnight, on a mechanical roller. The foam builder was introduced to the mixture by first preparing a premix of the foam builder at ranges from 0.5%, to 8.0% wt/wt, prepared in water/alcohol. The appropriate weight of premix was then added to the mixture containing the other coinponents prior to the step of mixing by rolling overniglzt.
According to the Material Safety Data Sheets of certain dimethicone copolyol surfactants, the surfactants are lcnown to contain significant quantities of PEO/PPO block copolymers of the type described herein as builders. These copolymers may be byproducts of the manufacturing process for the copolyol surfactants. The surfactants and builders used in the compositions of the Examples are listed in Tables 1 and 2.
Table 1- Surfactants Trade Name INCI Name Surfactant Mfr. Mfr. Location Abil B 8852 PEG/PPG-4/12 Goldschmidt Hopewell,VA
Dimethicone Chemical Corp.
Abil B 8873 PEG/PPG-35/65 Goldschmidt Hopewell,VA
Dimethicone 7,000MW Chemical Corp.
Dow 190 Fluid Dimethicone Dow Corning Midland, MI
Z PEG-12 Dimethicone Dow 193 Fluid Hydroxyl terminated, Dow Corning Midland, MI
Lambent MFF-164 Hydroxyl capped Lambent Gurnee, IL
dimethicone copolyol Technologies Inc.
Lambent AD Silicone uaternary 1 Lambent Gumee, IL
Quat Q Technologies Inc.
Silicone Quaternary 2 Lainbent Lambent Quat AM (Myristyl) Technologies Inc. Gumee, IL
Acrylic backbone Lambent Syngard 300 polymer with Lambent Gurnee, IL
dimethylsiloxane Technologies Inc.
sidechains Lambent Wax WS-L Dimethicone copolyol Lambent Gurnee, IL
Laurate Technologies Inc.
Lambent Wax WS-p Silicone Copolyol Lainbent Gurnee, IL
Pelargonate Teclinologies Inc.
Pecosil DCL Dimethicone Copolyol PCI Pheonix Somerville, NJ
Lactate Chemical, Inc.
Sodium Dimethicone PCI Pheonix Pecosil DCT Copolyol Acetyl Somerville, NJ
Methytaurate Chemical, Inc.
Q2-5220 Resin Modifier 3 PEG/PPG- 17/18 Dimethicone Dow Corning Midland, MI
Silicone Copolyol Lambent Silwax WD-IS Isostearate Tecluiologies Inc. Gurnee, IL
PEG Dimethicone, Silwet 77 Methoxy Terininated, GE Silicones Midland, MI
Table 1- Surfactants Trade Name INCI Name Surfactant Mfr. Mfr. Location Silwet L-7001 EO/PO, Methoxy GE Silicones Wilton, CT
terminated 20,000MW
Silwet L-7200 Dimethicone Copolyol GE Silicones Midland, MI
PPO Dimethicone, Silwet L-7500 Butoxy Terminated, GE Silicones Midl4nd, MI
3,000MW
PEG Diinethicone, Silwet L-7602 Methoxy Terminated, GE Silicones Wilton, CT
PEG Dimethicone, Silwet L-7604 Hydroxy Terminated, GE Silicones Midland, MI
PEG Dimethicone, Silwet L-7605 Methoxy Terminated, GE Silicones Wilton, CT
PEG Dimethicone, Silwet L-7614 Hydroxy Terminated, GE Silicones Wilton, CT
3MTn' Silicones "Plus" polysilicone-8 3M Company St. Paul, MN
Polymer VS80 1. Dow 190 surfactant includes poly(ethylene oxide, propylene oxide) monoallyl ether acetate and polyether polyol acetate.
2. Dow 193 surfactant includes polyethylene oxide monoallyl ether.
3. Q2-5220 Resin Modifier includes poly(ethylene oxide, propylene oxide) monoallyl ether acetate; polyethylene glycol monoallyl ether acetate; and polyether polyol acetate.
Table 2 - Foam Builders Trade Name Description Supplier / Mfr. Mfr. Location Aqualon EC K100 Ethylcellulose Hercules Wilmington, DE
PEG-150 Pentaerythrityl Parsippany, Crotliix Liquid tetrastearate (and) PEG-6 Croda NJ
Capric/Caprylic glycerides Economy Ecopol 120-S Hydroxypropyl Guar Polymers and Houston, TX
Chemicals Ganex Butylated Polyvinyl ISP Wayne, NJ
P-904LC Pyrrolidone Technologies Natrosol Plus Cetyl Hercules Wilmington, hydroxyethylcellulose DE
Table 2 - Foam Builders Trade Name Description Supplier / Mfr. Mfr. Location International Plasdone PVP K-120 Polyvinyl Pyrrolidone Specialty Wayne, NJ
Products Phtronic Ethylene Oxide/Propylene BASF Florham Park, F-108 Oxide Block Copolymer NJ
Pluronic Ethylene Oxide/Propylene BASF Florham Park, F-127 Oxide Block Copolymer NJ
Polyox WSR N12K poly(ethylene oxide) Dow Chemical Midland, MI
Ave MW 1,000,000 Co.
Polyox WSR N60K poly(ethylene oxide) Dow Chemical Midland, MI
Ave MW 2,000,000 Co.
Polyox WSR N-80 poly(ethylene oxide) Dow Chemical Midland, MI
Ave MW 200,000 Co.
Polyox WSR-301 poly(ethylene oxide) Dow Chemical Midland, MI
Ave MW 4,000,000 Co.
PVP K-90 Polyvinyl Pyrrolidone (K BASF Florham Park, value 90) NJ
Equipment Foam Pump - A foam pump nozzle was used to generate foanz from each composition.
The pump used was a pump dispenser, product Code F2, type F2-L1 1255/150, available from Airspray International Inc. of North Pompano Beach, FL.
Foam Collection vial - Vials were used to collect foam from the pump dispenser while the foam height was being measured. The vials were made of glass and were of either 40 or 80 nun height having a 25mm internal diameter and a 27mm outer diameter.
Test Methods Foam I-Ieight Test Procedure The Foam Pump was used to assess the foam forming property of the compositions. The pump was rinsed between samples with deionized water by pumping water through the pump until it ccune out clear. The pump dip tube was removed from the water and then pumped dry of residual water and then placed in the coinposition to be tested.
The pump was then pumped 3 times to prime the pump and then 3 more times to purge solution through the nozzle to ensure the system was ready. Finally, three pumps worth of foam were collected in a collection vial by pumping slowly at a speed of about 1 second for each pump. The vial containing the foam was placed on a flat surface, a timer was started and a small ruler witll millimeter increments was used to measure the approximate height of the foam, ignoring the height of any remaining unfoamed composition. The time to measure the foam height usually took about 5 seconds. Any composition producing a foam which was not stable at least 5 seconds was considered unstable and rated 0 mm. The foam height was estimated to be the average height of the foam. A rating of 0 mm was given if the top of the solution was void of foam in any spot, usually the center. The foam height was recorded after 1, 3 and 5 minutes to determine the long term stability of the foam.
Foam Volume % Increase The percentage of foam volume increase over the solution volume was calculated by measuring the foain heigllt in millimeters, subtracting 5mm from the foam height and dividing the result by 5 (the volume of the un-foamed pumped solution) and multiplying by 100%. Foam voluine % increase measurements were made immediately following creation of the foam (e.g., after dispensing). Due to the difficulty in determining the exact foam surface, foain heights between 0-5 mm were reported as having a zero percent increase in foain volume.
Viscosity Viscosity in centipoise (cP) was measured at 23 C at ambient pressure using a Brookfield viscometer Model LVT equipped with a Brookfield LV spindle # 1@ 60 rpm. All samples were allowed to equilibrate at 23 C for 24 hours prior to measurement.
The viscosity was taken at the lowest speed possible while staying within 10-100%
of the viscometer range and more preferably between 20-80% of the range. The viscosity was read after one minute of testing. In all cases the sample size and container geometry was chosen to ensure that there were no wall effects. By "wall effects" it is meant the viscosity value is not affected by the container and is essentially equivalent to the viscosity taken in an infinitely large container. For this reason lower viscosity sainples required a larger sample size to accoininodate the larger spindles.
Examples 1-13 Examples 1-13 were prepared using various amounts of the surfactant Dow 190;
plus a poly(ethylene oxide) (PEO) foam builder, available from Dow Chemical Company of Midland, MI, under the trade name POLYOX(TM) WSR N12K; distilled water, and an alcohol solvent. Foam heiglit measurements according to the above test method were taken for each saniple. The foam height measurements and formulations for each of the Examples are set forth in Table 3.
Dow 190 Foam Water SDAI Initial Foam Foam Foam BuilderN z Foam Height Height Height Example Sarf~ 12K Amt. (EtOH/ Il'A Height 1 min. 3 min. 5 min.
Amt. /~ Amt. % % IPA) mm mm mm mm 1 1.00 0.060 43.94 55.00 - 32 30 24 23 2 1.00 0.060 38.94 60.00 - 32 29 28 22 3 1.00 0.060 35.17 63.77 - 35 33 29 20 4 1.00 0.060 28.94 70.00 - 34 32 26 18 5 1.00 0.060 23.94 75.00 - 28 26 21 17 6 1.00 0.060 18.94 80.00 - 30 29 23 14 7 1.00 0.060 43.94 - 55.00 36 35 32 28 8 1.00 0.060 34.94 - 64.00 35 33 29 23 9 0.50 0.060 35.44 - 64.00 25 23 20 14 10 1.00 0.060 23.94 - 75.00 17 5 1 0 11 1.00 0.060 18.94 80.00 - 35 32 25 16 12 1.00 0.060 8.94 90.00 - 27 23 14 8 13 1.00 0.060 34.94 0.00 64.00 26 25 21 14 1. SDA is Specially Denatured Alcohol (SDA-3-C): a mixture of 100 parts USP
200 proof Ethanol plus 5 parts isopropy] alcohol (IPA).
2. IPA is isopropyl alcohol, reagent grade.
3. n-propanol (reagent grade) was used instead of isopropyl alcohol.
Examples 14-32 Examples 14-32 were all prepared with the same alcohol solvent, foam builder, surfactant and water content. The only variation in Examples 14-32 was the type of surfactant used.
The alcohol solvent was SDA-3-C and was present at 64.00%; the foam builder was PEO
N12K (listed above) and was present at 0.06 %; the water content was 25.50%
and the amount of surfactant was 2.50%. Foam height data and foan'i volume % increased data are reported in Table 4 for each of the compositions.
Table 4 Initial Foam Foam Foam Foam Foam Height Height Height Volume Height 1 min. 3 min. 5 min. %
Example Surfact.Trade Name mm mm mm Mm Increase 14 Dow 190 Fluid 45 42 28 12 800%
15 Dow 193 Fluid 30 0 0 0 500%
16 Abil B 8873 35 31 25 7 600%
17 Lambent MFF-164 34 32 28 22 580%
18 Lambent Quat AD 25 7 5 3 400%
19 Lambent Quat AM 30 0 0 0 500%
20 Lambent Wax WS-L 30 6 0 0 500%
21 Lambent Wax WS-p 35 26 0 0 600%
22 Pecosil DCL 34 20 0 0 580%
23 Pecosil DCT 15 0 0 0 200%
Q2-5220 Resin 24 Modifier 30 27 23 14 500%
Q2-5220 Resin 24 Modifier 30 27 23 14 500%
25 Silwax WD-IS 10 0 0 0 100%
26 Silwet 77 20 0 0 0 300%
27 Silwet L-7001 35 34 29 16 600%
28 Silwet L-7500 10 0 0 0 100%
29 Silwet L-7602 38 5 0 0 660%
30 Silwet L-7604 34 0 0 0 580%
31 Silwet L-7605 30 0 0 0 500%
32 Silwet L-7614 30 0 0 0 500%
Examples 33 - 53 and Comparative Examples C1- C6 The Examples 33 - 53 were all prepared with the same alcohol content of 65.00%
USP
200 proof ethanol. The amounts and type of surfactant, the ainount of foam builder and the water content were varied. Comparative Examples Cl - C4 had no surfactant.
Examples C5 and C6 had no builder. Formulations, initial foam height measurements and foam volume % increases are reported in Table 5.
Table 5 Foam Initial Foam Foam Surf. Water Foam Builder Visc. Foam Height Height Vol. %
Example Surf. Type Amt. N12K Amt. Cp Height 1 min. 3 min. Increase ~o Amt.% % mm mm mm C1 Silwet 0.00 0.000 35.00 3.4 0 0 0 0%
Examples 33 - 53 and Comparative Examples C1- C6 The Examples 33 - 53 were all prepared with the same alcohol content of 65.00%
USP
200 proof ethanol. The amounts and type of surfactant, the ainount of foam builder and the water content were varied. Comparative Examples Cl - C4 had no surfactant.
Examples C5 and C6 had no builder. Formulations, initial foam height measurements and foam volume % increases are reported in Table 5.
Table 5 Foam Initial Foam Foam Surf. Water Foam Builder Visc. Foam Height Height Vol. %
Example Surf. Type Amt. N12K Amt. Cp Height 1 min. 3 min. Increase ~o Amt.% % mm mm mm C1 Silwet 0.00 0.000 35.00 3.4 0 0 0 0%
33 Silwet 0.10 0.000 34.90 3.1 5 0 0 0%
34 Silwet 1.00 0.000 34.00 3.5 10 5 1 100%
C2 Silwet 0.00 0.060 34.94 3.8 0 0 0 0%
C2 Silwet 0.00 0.060 34.94 3.8 0 0 0 0%
35 Silwet 0.10 0.060 34.84 4.1 18 0 0 260%
36 Silwet 1.00 0.060 33.94 4.0 21 3 0 320%
37 Silwet 5.00 0.060 29.94 3.9 17 0 0 240%
C3 Silwet 0.00 0.200 34.80 5.6 0 0 0 0%
C3 Silwet 0.00 0.200 34.80 5.6 0 0 0 0%
38 Silwet 0.10 0.200 34.70 5.5 18 0 0 260%
39 Silwet 1.00 0.200 33.80 4.9 23 18 0 360%
C4 Silwet 0.00 0.500 34.50 15.4 0 0 0 0%
C4 Silwet 0.00 0.500 34.50 15.4 0 0 0 0%
40 Silwet 0.10 0.500 34.40 16.5 16 0 0 220%
41 Dow 190 1.00 0.060 33.94 3.9 40 38 35 700%
42 Dow 190 1.00 0.000 34.00 1.5 15 9 6 200%
43 La~bDent 1.00 0.060 33.94 4.0 20 0 0 300%
C5 I'~AD 11t 1.00 0.000 34.00 3.1 0 0 0 0%
C5 I'~AD 11t 1.00 0.000 34.00 3.1 0 0 0 0%
44 Lambent 1.00 0.060 33.94 4.1 34 30 8 580 l0 W S-P
45 Lambent 1.00 0.000 34.00 3.0 11 8 3 120%
WS-P
WS-P
46 MFF-164 1.00 0.060 33.94 3.0 35 34 32 600%
47 MFF-164 1.00 0.000 34.00 2.5 14 10 7 180%
48 PDCT ecosil 1.00 0.060 33.94 3.5 10 0 0 100%
C6 PDCT ecosil 1.00 0.000 34.00 3.0 0 0 0 0%
C6 PDCT ecosil 1.00 0.000 34.00 3.0 0 0 0 0%
49 Silwet 1.00 0.500 33.50 16.0 17 13 0 240%
Lambent 50 Syngard 1.00 0.060 34.94 nt~ 33 32 30 560%
Lambent 50 Syngard 1.00 0.060 34.94 nt~ 33 32 30 560%
51 Abil B 1.00 0.060 34.94 nt 34 34 20 580%
52 Silwet L- 1.00 0.060 34.94 nt 37 39 32 640%
53 3M VS80 1.00 0.060 34.94 nt 26 18 14 420%
1. "nt" - not tested.
Examples 54 - 64 Examples 54 - 64 were all prepared with the same alcohol content of 65.00% USP
proof ethanol and the same surfactant content of 1.00% Q2-5220 Resin Modifier.
The amounts and the type of foam builder were varied as was the water content.
Composition, foam height aiid foam volume % increase are reported in Table 6.
Table 6 Initial Foam Foam Foam Foam Foam Water Foam Visc. Foam Height Height Height %
Example Builder Builder Amt. Vol. /o Type Amt.% % Cp Height 1 min. 3 min. 5 min. Increase mm mm mm Mm 54 None 0.000 34.00 ntl 10 9 7 6 100%
1. "nt" - not tested.
Examples 54 - 64 Examples 54 - 64 were all prepared with the same alcohol content of 65.00% USP
proof ethanol and the same surfactant content of 1.00% Q2-5220 Resin Modifier.
The amounts and the type of foam builder were varied as was the water content.
Composition, foam height aiid foam volume % increase are reported in Table 6.
Table 6 Initial Foam Foam Foam Foam Foam Water Foam Visc. Foam Height Height Height %
Example Builder Builder Amt. Vol. /o Type Amt.% % Cp Height 1 min. 3 min. 5 min. Increase mm mm mm Mm 54 None 0.000 34.00 ntl 10 9 7 6 100%
55 Crotl7ix 0.080 33.92 nt 12 10 7 7 140%
56 Crotliix 0.300 33.70 4.9 12 9 8 6 140%
57 P-9Gailex 04LC 0.080 33.92 nt 11 9 8 8 120%
58 P 9Gaiiex 04LC 0.300 33.70 7.4 10 8 8 7 100%
59 Pluronic 0.080 33.92 nt 10 7 6 6 100%
60 Pluronic 0.300 33.70 3.1 10 9 7 7 100%
61 PF-127c 0.080 33.92 nt 11 9 7 6 120%
62 P~u127c 0.300 33.70 8.6 13 10 9 9 160%
63 PVP K-90 0.080 33.92 nt 13 10 9 7 160%
64 PVP K-90 0.300 33.70 4.3 9 9 6 6 80%
1. "nt" - not tested.
Examples 65 - 73 Examples 65 - 73 were all prepared with the same surfactant content of 1.00%, Dow 190.
The amounts of foam builder, water content and USP 200 proof ethanol were all varied.
Additionally the type of foain builder was also varied. Composition, foam height and foam volume % increase are reported in Table 7.
Table 7 Initial Foam Foam Foam Foam Foam Water EtOH Foam Example Builder Builder Amt. Amt. Foam I-Ieight 13eight Height Vol. %
Type Amt.% % (yo Height 1 min. 3 min. 5 min. Increase mm mm mm Mm 65 None 0 34.00 65.00 15 13 11 9 200%
Natrosol 66 Plus 0.06 33.98 64.96 13 10 8 6 160%
Natrosol 67 Plus 0.35 33.88 64.77 6 6 4 4 20%
Aqualon 68 EC K100 0.06 33.98 64.96 15 11 10 8 200%
Aqualon 69 EC K100 0.35 33.88 64.77 13 10 8 8 160%
Ecopol 70 120-S 0.06 33.98 64.96 12 9 8 7 140%
Ecopol 71 120-S 0.35 33.88 64.77 17 15 14 11 240%
1. "nt" - not tested.
Examples 65 - 73 Examples 65 - 73 were all prepared with the same surfactant content of 1.00%, Dow 190.
The amounts of foam builder, water content and USP 200 proof ethanol were all varied.
Additionally the type of foain builder was also varied. Composition, foam height and foam volume % increase are reported in Table 7.
Table 7 Initial Foam Foam Foam Foam Foam Water EtOH Foam Example Builder Builder Amt. Amt. Foam I-Ieight 13eight Height Vol. %
Type Amt.% % (yo Height 1 min. 3 min. 5 min. Increase mm mm mm Mm 65 None 0 34.00 65.00 15 13 11 9 200%
Natrosol 66 Plus 0.06 33.98 64.96 13 10 8 6 160%
Natrosol 67 Plus 0.35 33.88 64.77 6 6 4 4 20%
Aqualon 68 EC K100 0.06 33.98 64.96 15 11 10 8 200%
Aqualon 69 EC K100 0.35 33.88 64.77 13 10 8 8 160%
Ecopol 70 120-S 0.06 33.98 64.96 12 9 8 7 140%
Ecopol 71 120-S 0.35 33.88 64.77 17 15 14 11 240%
72 PVP K-120 0.06 33.98 64.96 14 11 9 8 180%
73 PVP K-120 0.35 33.88 64.77 9 7 6 6 80%
Examples 74 - 78 Examples 74 - 78 were formulated using PEO builders of different molecular weights.
Dow 190 in an ainount of 1.00% was used as the surfactant for all of the Examples 68-72.
Formulation information and foam height data are given in Table 7. Fluid at an amount of 1.00%.
Table 8 PEO Foam PEO Foam Foam Water Alcohol Initial Foam Foam Foam Example Builder Builder Builder Amt. Solvent Foam Height Height Height Type MW Amt.% % Amt. %1 Height 1 min. 3 min. 5 min.
mm mm mm mm 74 WSR-301 4,000,000 0.060 29.94 69.00 22 15 10 8 75 N60K 2,000,000 0.060 29.94 69.00 28 24 20 14 76 N12K 1,000,000 0.060 29,94 69.00 26 24 20 16 77 W g~ N 200,000 0.060 34.94 64.00 14 13 11 9 78 none 0 0.0 35.00 64.00 9 9 8 8 1. The alcohol in Examples 68 - 70 was 190 proof USP ethanol. The alcohol in Examples 71 - 72 was SDA-3-C alcohol solvent.
Secondary Antimicrobials Table 91ist various additional (secondary to alcohol) antimicrobials that were added to the formulations described in Examples 73-76.
Table 9 Abbreviated Name Descriptioii Supplier / Mfr. Mfr. Location Medichem, S. A, CHG 20 % Chlorhexidine distributed by Paramus, NJ
Gluconate solution George Uhe Coinpany, Inc.
PCMX para-chloro-meta- Ferro Cleveland, OH
xylenol Corporation Triclosan IRGASAN 1z DP 300 Ciba Greensboro, NC
Citric Acid Citric Acid MCB Reagents Rahway, NJ
GML Glycerol inonolaurate Med-Chem Labs Galena, IL
Abbreviated Name Description Supplier / Mfr. Mfr. Location SCL Sodium Capril Lactylate Rita Corp. Woodstock, IL
Examples 79 - 82 Examples 79 - 82 were formulated with the same components except that different secondary antimicrobials were used, as shown in Table 10. Foain height and foam volume % increase data are also set forth in Table 10.
Table 10 Surf. Foam Anti- Initial Foam Water Alcohol Secondary Foam Dow Builder Micro. Foam Height Vol. %
Example 190 WSR- Amt. SDA-3-C Anti- Amt. Height 5 min. Increase Amt.% N12K % Amt. % Micro. % mm mm 79 1.00 0.060 34.17 63.77 CHG 1.00 35 15 600%
Examples 74 - 78 Examples 74 - 78 were formulated using PEO builders of different molecular weights.
Dow 190 in an ainount of 1.00% was used as the surfactant for all of the Examples 68-72.
Formulation information and foam height data are given in Table 7. Fluid at an amount of 1.00%.
Table 8 PEO Foam PEO Foam Foam Water Alcohol Initial Foam Foam Foam Example Builder Builder Builder Amt. Solvent Foam Height Height Height Type MW Amt.% % Amt. %1 Height 1 min. 3 min. 5 min.
mm mm mm mm 74 WSR-301 4,000,000 0.060 29.94 69.00 22 15 10 8 75 N60K 2,000,000 0.060 29.94 69.00 28 24 20 14 76 N12K 1,000,000 0.060 29,94 69.00 26 24 20 16 77 W g~ N 200,000 0.060 34.94 64.00 14 13 11 9 78 none 0 0.0 35.00 64.00 9 9 8 8 1. The alcohol in Examples 68 - 70 was 190 proof USP ethanol. The alcohol in Examples 71 - 72 was SDA-3-C alcohol solvent.
Secondary Antimicrobials Table 91ist various additional (secondary to alcohol) antimicrobials that were added to the formulations described in Examples 73-76.
Table 9 Abbreviated Name Descriptioii Supplier / Mfr. Mfr. Location Medichem, S. A, CHG 20 % Chlorhexidine distributed by Paramus, NJ
Gluconate solution George Uhe Coinpany, Inc.
PCMX para-chloro-meta- Ferro Cleveland, OH
xylenol Corporation Triclosan IRGASAN 1z DP 300 Ciba Greensboro, NC
Citric Acid Citric Acid MCB Reagents Rahway, NJ
GML Glycerol inonolaurate Med-Chem Labs Galena, IL
Abbreviated Name Description Supplier / Mfr. Mfr. Location SCL Sodium Capril Lactylate Rita Corp. Woodstock, IL
Examples 79 - 82 Examples 79 - 82 were formulated with the same components except that different secondary antimicrobials were used, as shown in Table 10. Foain height and foam volume % increase data are also set forth in Table 10.
Table 10 Surf. Foam Anti- Initial Foam Water Alcohol Secondary Foam Dow Builder Micro. Foam Height Vol. %
Example 190 WSR- Amt. SDA-3-C Anti- Amt. Height 5 min. Increase Amt.% N12K % Amt. % Micro. % mm mm 79 1.00 0.060 34.17 63.77 CHG 1.00 35 15 600%
80 1.00 0.060 34.17 63.77 PCMX 1.00 40 15 700%
81 1.00 0.060 34.17 63.77 Triclosan 1.00 36 12 620%
82 1.00 0.060 31.97 63.77 GML+CA 1.00 26 2 420%
+SCL
1. Glycerol monolaurate at 1.00%+ 2.00% citric acid + 0.1% sodium capril lactylate Examples 83 - 107 Examples 83 - 107 were prepared to have the same alcohol content of 69.00%of proof ethanol. The Dow 190 surfactant and WSR-301 foam builder were used in various amounts as described in Table 11. Additionally, one or more emollient was added to each of the formulations. Formulations, initial foam height measurements and foam volume %
increase are reported in Table 11.
Table 11 Surf. Foam Water Initial Foam Foam Foam Dow Builder l z 3 Foam Height Height %
Example Amt. Ml M2 M3 Vol. /o 190 WSR301 Height 1 min. 3 min. Increase Amt.'YO Amt.% mm mm mm 83 1.00 0.06 28.94 1.00 0.00 0.00 24 18 14 380%
+SCL
1. Glycerol monolaurate at 1.00%+ 2.00% citric acid + 0.1% sodium capril lactylate Examples 83 - 107 Examples 83 - 107 were prepared to have the same alcohol content of 69.00%of proof ethanol. The Dow 190 surfactant and WSR-301 foam builder were used in various amounts as described in Table 11. Additionally, one or more emollient was added to each of the formulations. Formulations, initial foam height measurements and foam volume %
increase are reported in Table 11.
Table 11 Surf. Foam Water Initial Foam Foam Foam Dow Builder l z 3 Foam Height Height %
Example Amt. Ml M2 M3 Vol. /o 190 WSR301 Height 1 min. 3 min. Increase Amt.'YO Amt.% mm mm mm 83 1.00 0.06 28.94 1.00 0.00 0.00 24 18 14 380%
84 3.00 0.01 26.50 0.50 0.00 1.00 15 12 10 200%
85 2.00 0.01 26.00 1.00 1.00 1.00 17 14 10 240%
86 1.00 0.06 27.94 1.00 1.00 0.00 20 15 10 300%
87 3.00 0.06 26.00 0.00 1.44 0.50 29 25 22 480%
88 1.49 0.04 26.49 0.50 2.00 0.50 30 28 26 500%
89 3.00 0.04 26.00 0,00 0.97 1.00 34 31 24 580%
90 1.00 0.01 27.99 0.00 1.00 1.00 12 9 8 140%
91 1.00 0.01 27.99 1.00 0.00 1.00 14 9 8 180%
92 1.00 0.01 29.00 0.50 0.50 0.00 15 10 8 200%
93 3.00 0.06 26.00 1.00 0.94 0.00 25 20 18 400%
94 1.94 0.06 26.00 1.00 2.00 0.00 30 28 23 500%
95 1.00 0.06 28.94 0.00 0.00 1.00 27 22 16 440%
96 1.00 0.01 26.99 1.00 2.00 0.00 15 11 9 200%
97 1.50 0.01 29.00 0.00 0.00 0.50 15 10 10 200%
98 3.00 0.01 26.00 0.00 1.99 0.00 15 13 9 200%
99 2.97 0.06 26.00 1.00 0.00 0.97 25 23 18 400%
100 3.00 0.01 26.00 0.00 1.99 0.00 16 14 12 220%
101 2.00 0.06 27.94 0.00 0.00 1.00 30 22 17 500%
102 1.91 0.06 27.10 0.51 0.91 0.51 36 31 25 620%
103 1.00 0.01 26.99 0,00 2.00 1.00 14 10 7 180%
104 1.00 0.06 27.94 0.00 2.00 0.00 30 25 21 500%
105 3.00 0.01 26.99 1.00 0.00 0.00 15 12 8 200%
106 1.00 0.06 26.00 0.97 1.97 1.00 31 30 25 520%
107 2,00 0.06 27.94 1.00 0.00 0.00 31 28 20 520%
1. Ml was Myristyl Alcohol, available fi=om Sasol Noi-th America, Westlake, LA.
2. M2 was G-18-0, glycereth 18 ethylhexanoate, available from Global 7, Franklin, NJ.
3. M3 was Glycerol, available from from Dow Chemical, Midland MI.
Examples 108 - 113 Example 108 - 113 were prepared with the same alcohol content of 63.77 % SDA-3-C; the same amount of surfactant, Dow 190 at 1.00% and the same foam builder PEO, N12K, at an amount of 0.060%, The type and amount emollient was varied, as was the amount of water. Initial foam height measurements and foam voltime % increase were taken and are reported in Table 12.
Table 12 Water Initial Foam Foam Foam Foam l Z 3 Foam Height Height Height Vol.
Amt. Ml M4 M5 Height 1 min. 3 min. 5 min. . /o ~O Increase mm Mni mm mm 108 34.67 0.50 0.00 0.00 38 33 28 18 660%
1. Ml was Myristyl Alcohol, available fi=om Sasol Noi-th America, Westlake, LA.
2. M2 was G-18-0, glycereth 18 ethylhexanoate, available from Global 7, Franklin, NJ.
3. M3 was Glycerol, available from from Dow Chemical, Midland MI.
Examples 108 - 113 Example 108 - 113 were prepared with the same alcohol content of 63.77 % SDA-3-C; the same amount of surfactant, Dow 190 at 1.00% and the same foam builder PEO, N12K, at an amount of 0.060%, The type and amount emollient was varied, as was the amount of water. Initial foam height measurements and foam voltime % increase were taken and are reported in Table 12.
Table 12 Water Initial Foam Foam Foam Foam l Z 3 Foam Height Height Height Vol.
Amt. Ml M4 M5 Height 1 min. 3 min. 5 min. . /o ~O Increase mm Mni mm mm 108 34.67 0.50 0.00 0.00 38 33 28 18 660%
109 34.17 1.00 0.00 0.00 37 34 23 13 640%
110 33.17 2.00 0.00 0.00 30 28 24 15 500%
111 32.17 3.00 0.00 0.00 30 24 24 15 500%
112 32.17 0.00 3.00 0.00 36 35 30 21 620%
113 32.17 0.00 0.00 3.00 35 34 26 15 600%
1. Ml : Myristyl Alcohol, available from Sasol North America, Westlake, LA.
2. M4: Triethyl Citt=ate, NF available from Morflex Inc. of Greensboro, NC.
3. M5: Acetyl Triethyl Citrate, NF available from Morflex Inc. of Greensboro NC.
Table 13 Components for Comparative Examples C7 - C16 Trade/Abbrev. Name Description Supplier / Mfr. Mfr. Location Cocamido Propyl onateric CAB-NPB Betaine Uniqema Wilmington, DE
3RIJ 52 PEO 2 cetyl alcohol Uniqema Wilmington, DE
Dimethicone Copolyol 19,000 MW 75/25 Silwet L-7200 EO/PO Ratio GE Silicones Midland, MI
Standainid KD Cocamide DEA Kraft Chemical Co. Melrose Park, IL
Super Solen PEG-75 PEG-75 Lanolin Croda Parsippany, NJ
Myristyl Alcohol Myristyl Alcohol Sasol Westlake, LA
PEO 4 Sorbitan mono Tween 61 stearate Uniqema Wilmington, DE
Table 13 Components for Comparative Examples C7 - C16 Trade/Abbrev. Name Description Supplier / Mfr. Mfr. Location ermal DIA Diisopropyl Adipate Alzo International Sayreville, NJ
50:50 wt blend of Cetyl Cetearyl alcohol and Stearyl alcohol Croda Parsippany, NJ
G Propylene Glycol Dow Chemical Midland, MI
Hydroxypropyl ethocel 40-100 metlzylcellulose Dow Chemical Midland, MI
Hydroxy Propyl lucel Cellulose Hercules Wilmington, DE
cetearyl alcohol and tapro 300 ceteareth-20 Rita Corp. Woodstock, IL
3rij 72 Steareth-2 Uniqema Wilmington, DE
3rij 721 Steareth-21 Uniqema Wilmington, DE
Polysorbate 80 Sigma Chemical olysorbate 80 Co. St. Louis, MO
Poly ethylene glycol EG 400 400 MW Dow Chemical Midland, MI
Sodium Dodecyl Sodium Dodecyl enzene sulfonate benzene sulfonate Pfaltz and Bauer Waterbury, CT
Citric Acid Citric Acid MCB Reagents Rahway, NJ
Glycerol monolaurate Glycerol monolaurate Med-Chem Labs Galena, IL
Sodium Capril Sodilun Capril actylate Lactylate Rita Corp. Woodstock, IL
Comparative Examples C7 - C8 Comparative Examples C7 and C8 were tested for initial foam height after being prepared using the materials of Table 13 in the amounts listed in Tables 14A and 14B.
Table 14A
CHG Cetearyl Tweeii USP Initial Foam Example Soln. alcohol 61 PG Ethanol Water Height mm 20% 1901 roof C7 5.00 2.50 0.50 3.00 57.00 22.80 0 Table 14B
Example Myristyl Brij 52 Glycerol 1PA Water Initial Foam alcohol Height mm C8 3.00 0.80 2.50 60.00 25.40 0 Comparative Examples C9 - C11 Comparative Examples C9, C 10 and C 11 were prepared using the materials listed in Table 13 in the ainounts listed in Table 15 and were tested using the standard Foam Height procedure described above. The Initial Foam Height for each Comparative Example C9 -C11, was 0 mm.
Table 15 Cocamido Kraft USP
Silwet L- Methocel PEG-75 Ethanol Ex. # 7200 Propyl Standamid 40-100 Lanolin Glycerin IPA 200 Water Betaine KD Proof C9 0.20 10.00 7.00 1.00 3.00 0.20 - 60.00 17.97 C 10 0.25 10.00 7.00 1.00 3.00 0.05 - 60.00 18.07 C 11 0.25 10.00 7.00 1.00 3.00 0.05 70.0 - 8.07 Comparative Exam-ples C12 - C14 Comparative Examples C12, C 13 and C14 were prepared using.various materials of Table 13 in the ainounts listed in Table 16 and were tested using the standard Foam Height procedure described above.
Table 16 USP CHG Initial Ex. # Ritapro 2,rij 72 Brij 721 Klucel Ethanol Water 20% Foam 300 200 Soln. Height Proof mm C12 2.50 1.88 0.625 0.20 60.00 14.62 0.060 0 C13 2.50 1.88 0.625 0.20 60.00 24.71 0.200 0 C14 2.50 1.88 0.625 0.20 60.00 32.23 0.200 0 Comparative Examples C15 - C16 Comparative Examples C 15 and C 16 were prepared using various materials of Table 13 in the amounts listed in Table 17 and were tested using the standard Foam Height procedure described above.
Table 17 Sodium USP Initial Dodecyl Polysorbate Propylene Ethanol Foam Ex. # benzene 80 Glycerol PEG 400 glycol 200 Water Height sulfonate Proof mm C15 3.00 1.00 1.50 0.50 0.00 55.00 37.25 0 C16 3.00 3.00 0.00 0.00 2.00 60.00 31.00 0 Various modifications and alterations of the present invention will be apparent to those skilled in the art without departing from the scope and spirit of the present invention. The Examples described in this application are illustrative of the possibilities of varying the type, quantity and ratio of composition as well as the methods for making formulations of the present invention.
1. Ml : Myristyl Alcohol, available from Sasol North America, Westlake, LA.
2. M4: Triethyl Citt=ate, NF available from Morflex Inc. of Greensboro, NC.
3. M5: Acetyl Triethyl Citrate, NF available from Morflex Inc. of Greensboro NC.
Table 13 Components for Comparative Examples C7 - C16 Trade/Abbrev. Name Description Supplier / Mfr. Mfr. Location Cocamido Propyl onateric CAB-NPB Betaine Uniqema Wilmington, DE
3RIJ 52 PEO 2 cetyl alcohol Uniqema Wilmington, DE
Dimethicone Copolyol 19,000 MW 75/25 Silwet L-7200 EO/PO Ratio GE Silicones Midland, MI
Standainid KD Cocamide DEA Kraft Chemical Co. Melrose Park, IL
Super Solen PEG-75 PEG-75 Lanolin Croda Parsippany, NJ
Myristyl Alcohol Myristyl Alcohol Sasol Westlake, LA
PEO 4 Sorbitan mono Tween 61 stearate Uniqema Wilmington, DE
Table 13 Components for Comparative Examples C7 - C16 Trade/Abbrev. Name Description Supplier / Mfr. Mfr. Location ermal DIA Diisopropyl Adipate Alzo International Sayreville, NJ
50:50 wt blend of Cetyl Cetearyl alcohol and Stearyl alcohol Croda Parsippany, NJ
G Propylene Glycol Dow Chemical Midland, MI
Hydroxypropyl ethocel 40-100 metlzylcellulose Dow Chemical Midland, MI
Hydroxy Propyl lucel Cellulose Hercules Wilmington, DE
cetearyl alcohol and tapro 300 ceteareth-20 Rita Corp. Woodstock, IL
3rij 72 Steareth-2 Uniqema Wilmington, DE
3rij 721 Steareth-21 Uniqema Wilmington, DE
Polysorbate 80 Sigma Chemical olysorbate 80 Co. St. Louis, MO
Poly ethylene glycol EG 400 400 MW Dow Chemical Midland, MI
Sodium Dodecyl Sodium Dodecyl enzene sulfonate benzene sulfonate Pfaltz and Bauer Waterbury, CT
Citric Acid Citric Acid MCB Reagents Rahway, NJ
Glycerol monolaurate Glycerol monolaurate Med-Chem Labs Galena, IL
Sodium Capril Sodilun Capril actylate Lactylate Rita Corp. Woodstock, IL
Comparative Examples C7 - C8 Comparative Examples C7 and C8 were tested for initial foam height after being prepared using the materials of Table 13 in the amounts listed in Tables 14A and 14B.
Table 14A
CHG Cetearyl Tweeii USP Initial Foam Example Soln. alcohol 61 PG Ethanol Water Height mm 20% 1901 roof C7 5.00 2.50 0.50 3.00 57.00 22.80 0 Table 14B
Example Myristyl Brij 52 Glycerol 1PA Water Initial Foam alcohol Height mm C8 3.00 0.80 2.50 60.00 25.40 0 Comparative Examples C9 - C11 Comparative Examples C9, C 10 and C 11 were prepared using the materials listed in Table 13 in the ainounts listed in Table 15 and were tested using the standard Foam Height procedure described above. The Initial Foam Height for each Comparative Example C9 -C11, was 0 mm.
Table 15 Cocamido Kraft USP
Silwet L- Methocel PEG-75 Ethanol Ex. # 7200 Propyl Standamid 40-100 Lanolin Glycerin IPA 200 Water Betaine KD Proof C9 0.20 10.00 7.00 1.00 3.00 0.20 - 60.00 17.97 C 10 0.25 10.00 7.00 1.00 3.00 0.05 - 60.00 18.07 C 11 0.25 10.00 7.00 1.00 3.00 0.05 70.0 - 8.07 Comparative Exam-ples C12 - C14 Comparative Examples C12, C 13 and C14 were prepared using.various materials of Table 13 in the ainounts listed in Table 16 and were tested using the standard Foam Height procedure described above.
Table 16 USP CHG Initial Ex. # Ritapro 2,rij 72 Brij 721 Klucel Ethanol Water 20% Foam 300 200 Soln. Height Proof mm C12 2.50 1.88 0.625 0.20 60.00 14.62 0.060 0 C13 2.50 1.88 0.625 0.20 60.00 24.71 0.200 0 C14 2.50 1.88 0.625 0.20 60.00 32.23 0.200 0 Comparative Examples C15 - C16 Comparative Examples C 15 and C 16 were prepared using various materials of Table 13 in the amounts listed in Table 17 and were tested using the standard Foam Height procedure described above.
Table 17 Sodium USP Initial Dodecyl Polysorbate Propylene Ethanol Foam Ex. # benzene 80 Glycerol PEG 400 glycol 200 Water Height sulfonate Proof mm C15 3.00 1.00 1.50 0.50 0.00 55.00 37.25 0 C16 3.00 3.00 0.00 0.00 2.00 60.00 31.00 0 Various modifications and alterations of the present invention will be apparent to those skilled in the art without departing from the scope and spirit of the present invention. The Examples described in this application are illustrative of the possibilities of varying the type, quantity and ratio of composition as well as the methods for making formulations of the present invention.
Claims (19)
1. A composition, comprising:
(A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity;
(B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.
(A) Monohydric alcohol in an amount sufficient to provide antimicrobial activity;
(B) Surfactant comprising a dimethicone surfactant; and (C) Builder, the builder in an amount sufficient to provide stability or to improve the stability of a foam formed from the composition.
2. The composition as defined in claim 1, wherein the monohydric alcohol is selected from the group consisting of ethanol, propanol, butanol and combinations of two or more of the foregoing.
3. The composition as defined in claim 2, wherein the monohydric alcohol is present in the composition at a concentration from about 35% to about 99.5% by weight.
4. The composition as defined in claim 1, wherein the surfactant is present in the composition at a concentration from about 0.1 % to about 10% by weight.
5. The composition as defined in claim 1, wherein the dimethicone surfactant is selected from the group consisting of methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 3000; dimethicone with a pendant ether of 35/65 (w/w) polyethylene glycol / polypropylene glycol copolymer having a combined average molecular weight of about 7,000; dimethicone copolyol with 18/18 (molar ratio) polyethylene glycol / polypropylene glycol; dimethicone copolyol with 17/18 (molar ratio) polyethylene glycol / polypropylene glycol;
dimethicone copolyol with polyethylene glycol / polypropylene glycol - methoxy terminated having an average molecular weight of about 20,000 and a hydrophile-liphophile balance of 9-12;
dimethicone copolyol with a methoxy- terminated polyethylene glycol having a combined average molecular weight of about 3000; dimethicone copolyol with a methoxy-terminated polyethylene glycol having a combined average molecular weight of about 6000; dimethicone copolyol with a hydroxy terminated polyethylene glycol having a combined average molecular weight of about 5000 with a hydrophile-liphophile balance of 13-17; dimethicone copolyol lactate; silicone copolyol pelargonate; hydroxyl-capped dimethicone copolyol; hydroxyl-terminated polyethylene glycol-12 dimethicone;
dimethicone copolyol laurate; Silicone Quaternary 1; hydroxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 4000; methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 600; Silicone Quaternary 2 (Myristyl); sodium dimethicone copolyol acetyl methyltaurate; butoxy-terminated poly(propylene oxide) dimethicone having an average molecular weight of about 3,000; silicone copolyol isostearate; and combinations of two or more of the foregoing.
dimethicone copolyol with polyethylene glycol / polypropylene glycol - methoxy terminated having an average molecular weight of about 20,000 and a hydrophile-liphophile balance of 9-12;
dimethicone copolyol with a methoxy- terminated polyethylene glycol having a combined average molecular weight of about 3000; dimethicone copolyol with a methoxy-terminated polyethylene glycol having a combined average molecular weight of about 6000; dimethicone copolyol with a hydroxy terminated polyethylene glycol having a combined average molecular weight of about 5000 with a hydrophile-liphophile balance of 13-17; dimethicone copolyol lactate; silicone copolyol pelargonate; hydroxyl-capped dimethicone copolyol; hydroxyl-terminated polyethylene glycol-12 dimethicone;
dimethicone copolyol laurate; Silicone Quaternary 1; hydroxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 4000; methoxy-terminated polyethylene glycol dimethicone having an average molecular weight of about 600; Silicone Quaternary 2 (Myristyl); sodium dimethicone copolyol acetyl methyltaurate; butoxy-terminated poly(propylene oxide) dimethicone having an average molecular weight of about 3,000; silicone copolyol isostearate; and combinations of two or more of the foregoing.
6. The composition as defined in claim 1 wherein the dimethicone surfactant is selected from the group consisting of dimethicone bisamino hydroxypropyl copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyol almondate, dimethicone copolyolamine, dimethicone copolyol avocadoate, dimethicone copolyol beeswax, dimethicone copolyol behenate, dimethicone copolyol benzoate, dimethicone copolyol bishydroxy ethylamine, dimethicone copolyol borageate, dimethicone copolyol butyl ether, dimethicone copolyol cocoa butterate, dimethicone copolyol crosspolymer, dimethicone copolyol dhupa butterate, dimethicone copolyol ethyl ether, dimethicone copolyol hydroxy stearate, dimethicone copolyol isostearate, dimethicone copolyol kokum butterate, dimethicone copolyol lactate, dimethicone copolyol laurate, dimethicone copolyol mango butterate, dimethicone copolyol meadowfoamate, dimethicone copolyol methyl ether, dimethicone copolyol mohwa butterate, dimethicone copolyol octyldodecyl citrate, dimethicone copolyol olivate, dimethicone copolyol phosphate, dimethicone copolyol phthalate, dimethicone copolyol sal butterate, dimethicone copolyol shea butterate, dimethicone copolyol stearate, dimethicone copolyol undecylenate, dimethicone hydroxypropyl trimonium chloride, dimethicone propyl pg-betaine, polysilicone-10, polysilicone-8, dimethcone propylethylenediamine behenate, amino bispropyl dimethicone aminoethylaminopropyl dimethicone, behentrimonium dimethicone copolyol phthalate, bis-aminopropyl copolyol aminopropyl dimethicone, bis-hydroxyethoxypropyl dimethicone, cetyl triethylmonium dimethicone copolyol succinate, dimethicone copolyol sulfate, dimethicone copolyol phosphate, dimethicone polyglycerol, disodium copolyol dimethicone sulfosuccinate, copolyol polydimethylsiloxyethyl dimethicone, copolyol pg-coco-glucoside dimethicone, copolyol nonafluorohexyl dimethicone copolymer, copolyol methyl ether lauroxy peg amidopropyl dimethicone, copolyol oleyl ether dimethicone, sodium carboxydecyl copolyol dimethicone and combinations of two or more of the foregoing.
7. The composition as defined in claim 1, wherein the dimethicone surfactant comprises a molar ratio of polyethylene glycol to polypropylene glycol of about 18/18.
8. The composition as defined in claim 1 wherein the builder is selected from the group consisting of poly(ethylene oxide) having a molecular weight in the range from about 100,000 to 10,000,000, polyethylene - polypropylene copolymer, hydroxyethyl cellulose, hydroxypropyl cellulose and combinations of two or more of the foregoing and wherein the builder is present in the composition at a concentration between about 0.00 1%
and about 5% by weight.
and about 5% by weight.
9. The composition as defined in claim 1 wherein the builder is selected from the group consisting of hydroxypropyl guar, polyquaternium-4, polyquaternium-10, cetyl hydroxyethylcellulose, ethylhydroxy ethyl cellulose, polyglycerol, high molecular wt.
polyoxamer, high molecular wt. polyoxamine, polyacrylamide, high molecular wt polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-47, polyvinyl methyl ether, butylated poly vinyl pyrrolidone, hydroxypropyl methylcellulose; hydroxypropyl cellulose;
crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units and combinations of two or more of the foregoing.
polyoxamer, high molecular wt. polyoxamine, polyacrylamide, high molecular wt polyethylene glycol esters and ethers with alkyl alcohols or acid functional alkyls, polyacrylamidomethylpropane sulfonic acid, polyacrylic acid, polyethylene/isopropyl maleate/malaic acid copolyol, polymethacrylamidopropyltrimonium chloride, polymethacrylamidopropyltrimonium methosulfate, polymethacrylic acid, polyquaternium-1 to polyquaternium-47, polyvinyl methyl ether, butylated poly vinyl pyrrolidone, hydroxypropyl methylcellulose; hydroxypropyl cellulose;
crosslinked and non-crosslinked homopolymer or crosslinked and non-crosslinked copolymer containing n-vinyl lactam monomeric units and combinations of two or more of the foregoing.
10. The composition as defined in claim 1, further comprising an emollient wherein the emollient is present in the composition at a concentration of about 30% by weight or less.
11. The composition as defined in claim 1, further comprising a secondary antimicrobial agent, the secondary antimicrobial agent present in the composition at a concentration up to about 10% by weight, the secondary antimicrobial agent is selected from the group consisting of parachlorometaxylenol; triclosan; chlorhexidine and its salts, poly hexamethylene biguanide and its salts, iodine, idodophors; fatty acid monoesters;
poly-n-vinyl pyrrolidone-iodophors; silver oxide, silver and its salts, peroxides, antibiotics, and combinations of two or more of the foregoing.
poly-n-vinyl pyrrolidone-iodophors; silver oxide, silver and its salts, peroxides, antibiotics, and combinations of two or more of the foregoing.
12. The composition as defined in claim 1, further comprising one or more skin barrier materials in an amount from about 0.1 % to 60% by weight wherein the barrier material is selected from the group consisting of aldioxa, allantoin, aluminum acetate, aluminum hydroxide, bismuth subnitrate, boric acid, calamine, cellulose, cholecalciferol, cocoa butter, cod liver oil, colloidal oatmeal, cysteine hydrochloride, dexpanthenol, dimethicone, glycerin kaolin, lanolin, live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsam oil, pertrolatum, protein hydrolysate, racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbonate, zinc oxide and combinations of two or more of the foregoing.
13. The composition as defined in claim 1, further comprising an antifungal agent.
14. The composition as defined in claim 1, wherein the viscosity of the composition prior to foaming at 23° C is within the range from about 0.5 to about 100 cps.
15. The composition as defined in claim 1, further comprising a propellant selected from the group consisting of chlorofluorocarbons, hydrochlorofluorocarbons, hydrofluorocarbons, perfluorinated alkanes, lower alkanes having a carbon chain length of C1-C5, nitrous oxide dimethyl ether and combinations of two or more of the foregoing.
16. A system comprising a container and the composition as defined in claim 11, the composition contained within the container under pressure and the propellant being present within the composition at a concentration from about 2% to about 30%
by volume.
by volume.
17. A system comprising:
A dispenser comprising a reservoir and a hand pump; and The composition of claim 1 contained within the reservoir.
A dispenser comprising a reservoir and a hand pump; and The composition of claim 1 contained within the reservoir.
18. A skin sanitizer comprising the composition of claim 1.
19. A pre-surgical hand scrub comprising the composition of claim 1.
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US11/151,563 US7651990B2 (en) | 2005-06-13 | 2005-06-13 | Foamable alcohol compositions comprising alcohol and a silicone surfactant, systems and methods of use |
US11/151,563 | 2005-06-13 | ||
PCT/US2006/021904 WO2006138111A1 (en) | 2005-06-13 | 2006-06-06 | Foamable alcohol compositions, systems and methods of use |
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CA2610945C CA2610945C (en) | 2016-06-28 |
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EP (1) | EP1893167A1 (en) |
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CN101198308A (en) | 2008-06-11 |
NO20080261L (en) | 2008-03-10 |
US20090326076A1 (en) | 2009-12-31 |
JP5266049B2 (en) | 2013-08-21 |
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US7651990B2 (en) | 2010-01-26 |
KR101389199B1 (en) | 2014-04-24 |
JP2008546692A (en) | 2008-12-25 |
US20060281663A1 (en) | 2006-12-14 |
US20100331411A1 (en) | 2010-12-30 |
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AU2006259687B2 (en) | 2012-03-08 |
MX2007015768A (en) | 2008-02-15 |
CN101198308B (en) | 2013-04-10 |
AU2006259687A1 (en) | 2006-12-28 |
TW200710220A (en) | 2007-03-16 |
KR20080026546A (en) | 2008-03-25 |
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