CA2571571C - Improvements relating to automatic injection devices - Google Patents

Improvements relating to automatic injection devices Download PDF

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Publication number
CA2571571C
CA2571571C CA 2571571 CA2571571A CA2571571C CA 2571571 C CA2571571 C CA 2571571C CA 2571571 CA2571571 CA 2571571 CA 2571571 A CA2571571 A CA 2571571A CA 2571571 C CA2571571 C CA 2571571C
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CA
Canada
Prior art keywords
syringe
housing
plunger
injection device
position relative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 2571571
Other languages
French (fr)
Other versions
CA2571571A1 (en
Inventor
Stephen Bicknell
Joseph F. Julian
William L. Rudzena
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AbbVie Biotechnology Ltd
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AbbVie Biotechnology Ltd
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Filing date
Publication date
Application filed by AbbVie Biotechnology Ltd filed Critical AbbVie Biotechnology Ltd
Priority to CA 2776901 priority Critical patent/CA2776901A1/en
Publication of CA2571571A1 publication Critical patent/CA2571571A1/en
Application granted granted Critical
Publication of CA2571571C publication Critical patent/CA2571571C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion

Abstract

An injection device comprises a syringe (1) extendible against a spring bias (9) from a retracted position in a housing (2) to a projecting injecting position. A spring biased plunger has collapsible elbows (10) which, when the plunger is released, initially engage the end of the syringe to drive it to the projecting position, whereupon arresting of the syringe movement causes the elbows to collapse inside the syringe to allow the plunger to engage and drive the bung (4).

Description

Improvements relating to automatic injection devices There are various forms of automatic injection device which when operated cause the needle of a syringe to be moved forwardly so that it projects from a protective housing prior to actuation of the syringe to express a dose of liquid through the needle. It is important to try to ensure that the syringe is moved bodily forward to expose the needle before the liquid charge is pressurised so that dribbling from the needle does not occur before the actual injection takes place. It is an object of this invention to provide a mechanism which operates in this desired manner.
According to the invention there is provided an injection device for causing a dose of liquid to be ejected from the needle at one end of a syringe located within a housing of the device, the syringe being movable by a plunger, upon release of an actuating bias member at one end of the housing, to move the syringe, from a first position wherein the needle is shrouded by the housing, to a second position wherein the needle projects from the other end of the housing, the plunger being in the form of a rod with a longitudinally centrally located flexible projecting portion which, prior to release of said actuating bias member, is situated beyond the other end of the syringe, such that a primary movement of the plunger, under the bias of the actuating bias member, will cause the projecting portion to bear against the other end of the syringe such that the syringe is moved from said first to said second position, whereupon arresting of further movement of the syringe, results in the flexible portion collapsing inwardly so that it enters the syringe, thus enabling the plunger to move by a secondary movement, within the syringe, into contact with and to act upon a plug to compress the liquid within the syringe and cause expression of the liquid through the syringe needle.
With such an arrangement, the projecting portion will remain in its projecting position (in order to move the syringe from the first to the second position) until the force increases to such an extent which allows the projecting portion to collapse inwardly so that the plunger can then move within the syringe to cause the liquid to be expressed through the syringe.
The projecting portion can comprise one or more flexible elbows projecting beyond the normal circumference of the rod, but compressible into the circumference. This could be in the form of two elbows defined either side of a longitudinal slit in the rod. The elbows could be pre-formed as a pair of arms either side of the longitudinal slit between upper and lower solid portions of the rod.
Preferably the injection device will contain a return bias member acting between the syringe housing and the other end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released.
One or more of the bias members provided within the housing can be in the form of a coil spring.
In accordance with an embodiment of the present invention there is provided an injection device, comprising: a housing; a plunger in the form of a rod with a flexible projecting portion; a syringe located within the housing of the device, the syringe containing a moveable bung and being moveable relative to the housing by the plunger; a needle positioned at a distal end of the syringe; and an actuating bias member, wherein release of the actuating bias member at a proximal end of the housing drives the syringe from a first position relative to the housing wherein the needle is shrouded by the housing to a second position relative to the housing wherein the needle projects from a distal end of the housing. Prior to release of the actuating bias member, the flexible projecting portion of the plunger is situated rearwardly of a proximal end of the syringe. Upon release of the actuating bias member, movement of the plunger under the bias of the actuating bias member causes the flexible projecting portion to bear against the proximal end of the syringe such that the syringe is moved from the first position relative to the housing to the second position relative to the housing. Arresting of further movement of the syringe results in the flexible projecting portion collapsing inwardly so that the flexible projecting portion enters the syringe, thus enabling the plunger to move forwardly within the syringe to act upon the bung to compress a liquid within the syringe and cause expulsion of the liquid through the needle.
In accordance with another embodiment of the present invention there is provided an injection device, comprising: a housing; a syringe slideably mounted within the housing for movement between a shrouded retracted position relative to the housing and an extended injecting position relative to the housing; a bung slideably mounted in the syringe and moveable to expel a liquid dose through a needle at a distal end of the syringe; a plunger having an end operable to engage the bung and to transmit an expulsion force thereto; and a bias spring operable to move the plunger from a first position to a second position. The plunger is provided with a collapsible projecting region which is outside the syringe when the plunger is at its first position but which, when the plunger is moved away from the first position, engages a proximal end of the syringe to drive the syringe to its extended injecting position relative to the housing.
Arresting of further movement of the syringe causes collapsible projecting region to collapse inwardly so that the collapsible projecting region enters the syringe to allow the plunger to engage the bung and expel a liquid dose.
In accordance with a further embodiment of the present invention there is provided an injection device, comprising: a housing; a syringe slideably mounted within and relative to the housing for movement between a shrouded retracted position relative to the housing and an extended injecting position relative to the housing; a bung slideably mounted in the syringe and movable to expel a liquid dose from the syringe through a needle provided at a distal end of the syringe; a plunger comprising: an upper solid portion, a lower solid portion having a distal end operable to move the bung and to transmit an expulsion force thereto, and a collapsible projecting region comprising two flexible elbows disposed on either side of a centrally located longitudinal slit provided between the upper and lower solid portions of the plunger; an actuating bias member operable to move the plunger in order to drive the syringe from the shrouded retracted position relative to the housing to the extended injecting position relative to the housing; and a return bias member acting between the housing and a proximal end of the syringe to hold the syringe in the shrouded retracted position relative to the housing until the actuating bias member is released. The collapsible projecting region is in a first expanded position prior to entering the syringe. The collapsible projecting region is in a second compressed position within the syringe, in which the flexible elbows are collapsed inwardly toward the longitudinal slit, in order to apply the expulsion force to the bung to expel the liquid dose from the syringe.
In accordance with a further embodiment of the present invention there is provided an injection device comprising a housing; a syringe slideably mounted within the housing for movement between a shrouded retracted position relative to the housing and an extended injecting position relative to the housing; a bung slideably mounted in the syringe and moveable to expel a liquid dose through a needle at a distal end of the syringe; a plunger having an end operable to move the bung and to transmit an expulsion force thereto and having at least one integrally formed collapsible projecting region, the collapsible projecting region comprising two flexible elbows projecting beyond the normal circumference of the plunger but compressible into the circumference, the flexible elbows being a pair of arms on either side of a longitudinal slit provided between upper and lower solid portions of the plunger and centrally located within an outer surface of the plunger. The flexible elbows of the collapsible projecting region project beyond the normal circumference of the plunger prior to the collapsible projecting region entering the syringe. The flexible elbows of the collapsible projecting region are compressed into the normal circumference of the plunger when the collapsible projecting region enters the syringe for applying the expulsion force to the bung to expel the liquid dose from the syringe. A
bias spring is operable to move the plunger in order to drive the syringe from the shrouded retracted position relative to the housing to the extended injecting position relative to the housing.
In accordance with a further embodiment of the present invention there is provided an injection device, comprising a housing; a syringe coupled to a needle at one end, the syringe slideably mounted within the housing for movement between a first position relative to the housing in which the needle is shrouded by the housing and a second position relative to the housing in which the needle projects from the housing; a bung slideably mounted in the syringe and moveable to expel a liquid through the needle; a plunger comprising: an upper solid portion, a lower solid portion having one end operable to move the bung and to transmit an expulsion force thereto, and a projecting region comprising one or more flexible elbows on either side of a central void provided between the upper and lower solid portions of the plunger, the plunger having a first length when the projecting region is in a projecting position in which the one or more elbows project outwardly from the central void, the plunger having a second length greater than the first length when the projecting region is in a collapsed position in which the one or more elbows are collapsed inwardly toward the central void; and an actuating bias member provided at one end of the housing and operable to move the plunger toward another end of the housing.
In accordance with a further embodiment of the present invention there is provided a syringe assembly, comprising: a syringe coupled to a needle at one end, the syringe slideably mounted within a housing for movement between a first position relative to the housing in which the needle is shrouded by the housing and a second position relative to the housing in which the needle projects from the housing; a bung slideably mounted in the syringe; and a plunger comprising: an upper solid portion, a lower solid portion having one end operable to move the bung and to transmit an expulsion force thereto, and a projecting region comprising one or more flexible elbows on either side of a central void provided between the upper and lower solid portions of the plunger. The plunger has a first length when the projecting region is in a projecting position in which the one or more elbows project outwardly from the central void.
The plunger has a second length greater than the first length when the projecting region is in a collapsed position in which the one or more elbows are collapsed inwardly toward the central void.
The invention may be performed in various ways and a preferred example thereof will now be described, with reference to the accompanying diagrammatic drawings, in which:
Figure 1 is a sectional view through an injection device of this invention prior to use; and Figures 2 and 3 are similar views showing successive stages of operation of the injection member.
The injection device shown in the drawings comprises a syringe 1 located within a protective housing 2. The syringe comprises a container 3 incorporating a liquid dose held in place by a bung 4 and having a needle 5 through which the dose can be ejected by applying pressure to the bung 4. The container 3 has an enlarged head 6. A
plunger 7 is biased forwardly by a coil spring 8, but is held back in a latched position (Figure 1) until such time as a trigger shown schematically at 11 is actuated to release the plunger and the spring 8. Prior to use the syringe 1 is held retracted in the housing 2 by a coil spring 9.
It will be seen that the plunger 7 is in the form of a rod having a central portion which defines a pair of projecting elbows 10. These can be pre-formed as part of a moulded plunger 7. The projecting elbow portions 10 are flexible so that they can be moved inwardly to cause that portion of the rod to adopt a circumference similar to that of the rest of the rod.
As can be seen in Figure 2, when the plunger is released and biased by the spring 8 the expanded region formed by the elbows 10 rests against the head 801 the container 3 and the force provided is sufficient to compress the spring 9 until such time as the head 6 abuts the top of the housing 2, whereupon further movement of the container 3 is arrested. The continual bias created by the spring 8 then causes the elbows 10 to be compressed inwardly as they enter into the interior of the container 3. With the elbows 10 in the collapsed state, the plunger can then move relatively easily within the container 3 so as to act upon the bung 4 and thus cause the contents of the syringe to be ejected through the needle 5.
The illustrated configuration of the plunger 7 provides several technical advantages. It can be moulded integrally. Also the collapsing movement of the projecting elbows provides an arrangement which can provide a suitable injection force to cause the needle to enter the skin to a suitable depth, but then provide a relatively low drag against the inner wall of the syringe container so that the major portion of the thrust of the spring for the remainder of its stroke is applied to the bung 4. It will be appreciated that other configurations of collapsing projection could be used in place of the collapsing elbows.

Claims (39)

1. An injection device, comprising:
a housing (2);
a plunger (7) in the form of a rod with a flexible projecting portion (10);
a syringe (1) located within the housing (2) of the device, the syringe (1) containing a moveable bung (4) and being moveable relative to the housing (2) by the plunger (7);
a needle (5) positioned at a distal end of the syringe (1); and an actuating bias member (8), wherein release of the actuating bias member (8) at a proximal end of the housing (2) drives the syringe (1) from a first position relative to the housing (2) wherein the needle (5) is shrouded by the housing (2) to a second position relative to the housing (2) wherein the needle (5) projects from a distal end of the housing (2);
wherein, prior to release of the actuating bias member (8), the flexible projecting portion (10) of the plunger (7) is situated rearwardly of a proximal end (6) of the syringe (1);
wherein, upon release of the actuating bias member (8), movement of the plunger (7) under the bias of the actuating bias member (8) causes the flexible projecting portion (10) to bear against the proximal end (6) of the syringe (1) such that the syringe (1) is moved from the first position relative to the housing (2) to the second position relative to the housing (2); and wherein arresting of further movement of the syringe (1) results in the flexible projecting portion (10) collapsing inwardly so that the flexible projecting portion (10) enters the syringe (1), thus enabling the plunger (7) to move forwardly within the syringe (1) to act upon the bung (4) to compress a liquid within the syringe (1) and cause expulsion of the liquid through the needle (5).
2. The injection device as claimed in claim 1, wherein the flexible projecting portion (10) comprises two or more flexible elbows projecting beyond the normal circumference of the plunger (7), but compressible into said circumference.
3. The injection device as claimed in claim 2, wherein the two or more elbows (10) are defined on either side of a longitudinal slit in the plunger (7).
4. The injection device as claimed in claim 2, wherein the two or more elbows are preformed as a pair of arms (10) on either side of a longitudinal slit between upper and lower solid portions of the plunger (7).
5. The injection device as claimed in any one of claims 1 to 4, including a return bias member (9) acting between the housing (2) and the proximal end (6) of the syringe (1) to hold the syringe (1) retracted within the housing (2) until the actuating bias member (8) is released.
6. The injection device as claimed in claim 5, wherein the actuating bias member (8) and/or the return bias member (9) provided within the housing is in the form of a coil spring.
7 7. An injection device, comprising:
a housing (2);
a syringe (1) slideably mounted within said housing (2) for movement between a shrouded retracted position relative to the housing (2) and an extended injecting position relative to the housing (2);
a bung (4) slideably mounted in said syringe (1) and moveable to expel a liquid dose through a needle (5) at a distal end of the syringe;
a plunger (7) having an end operable to engage said bung (4) and to transmit an expulsion force thereto; and a bias spring (8) operable to move said plunger (7) from a first position to a second position;
characterized in that said plunger (7) is provided with a collapsible projecting region (10) which is outside said syringe (1) when said plunger (7) is at its first position but which, when the plunger (7) is moved away from said first position, engages a proximal end (6) of said syringe (1) to drive said syringe (1) to its extended injecting position relative to the housing (2), whereupon arresting of further movement of said syringe (1) causes said collapsible projecting region (10) to collapse inwardly so that the collapsible projecting region (10) enters the syringe (1) to allow said plunger (7) to engage said bung (4) and expel the liquid dose.
8 8. The injection device as claimed in claim 7, including a return bias member (9) acting between the housing (2) and the proximal end (6) of the syringe (1) to hold the syringe (1) retracted within the housing (2) until the bias spring (8) is released.
9. The injection device as claimed in claim 8, wherein the bias spring (8) and/or the return bias member (9) provided within the housing is in the form of a coil spring.
10. The injection device as claimed in any one of claims 7 to 9, wherein the arresting of further movement of the syringe (1) is caused when the plunger (7) is at its second position and when the proximal end (6) of the syringe (1) abuts a proximal end of the housing (2).
11. The injection device as claimed in any one of claims 7 to 10, wherein the inward collapse of the collapsible projecting region (10) is caused by the continual bias created by the bias spring (8) as the collapsible projecting region (10) enters the interior of the syringe (1),
12. The injection device as claimed in claim 7, wherein the collapsible projecting region (10) comprises two or more flexible elbows defined on either side of a void in the plunger (7).
13. The injection device as claimed in claim 12, wherein the two or more flexible elbows are preformed as a pair of arms on either side of the void between spaced front and rear solid portions of the plunger (7).
14. The injection device as claimed in claim 7, wherein the housing (2) is fixed at an injection site and wherein the syringe (1) moves within and relative to the housing (2).
15. The injection device as claimed in claim 1, wherein the housing (2) is fixed at an injection site and wherein the syringe (1) moves within and relative to the housing (2).
16. An injection device, comprising:
a housing (2);
a syringe (1) slideably mounted within and relative to the housing (2) for movement between a shrouded retracted position relative to the housing (2) and an extended injecting position relative to the housing (2);
a bung (4) slideably mounted in the syringe (1) and movable to expel a liquid dose from the syringe (1) through a needle (5) provided at a distal end of the syringe (1);
a plunger (7) comprising:
an upper solid portion, a lower solid portion having a distal end operable to move the bung (11) and to transmit an expulsion force thereto, and a collapsible projecting region (10) comprising two flexible elbows disposed on either side of a centrally located longitudinal slit provided between the upper and lower solid portions of the plunger (7);
an actuating bias member (8) operable to move the plunger in order to drive the syringe from the shrouded retracted position relative to the housing to the extended injecting position relative to the housing; and a return bias member (9) acting between the housing and a proximal end (6) of the syringe to hold the syringe in the shrouded retracted position relative to the housing (2) until the actuating bias member (8) is released;
wherein the collapsible projecting region (10) is in a first expanded position prior to entering the syringe (1); and wherein the collapsible projecting region (10) is in a second compressed position within the syringe (1), in which the flexible elbows are collapsed inwardly toward the longitudinal slit, in order to apply the expulsion force to the bung to expel the liquid dose from the syringe (1).
17. The injection device as claimed in claim 16, wherein the collapsible projecting region (10) of the plunger (7) is configured to drive the syringe (1) from the shrouded retracted position relative to the housing (2) to the extended injecting position relative to the housing (2) such that the needle (5) projects from the housing (2).
18. The injection device as claimed in claim 16, wherein one or both of the actuating bias member (8) and the return bias member (9) is in the form of a coil spring.
19. The injection device as claimed in claim 16, wherein the housing (2) is stationary relative to an injection site on a user's body as the syringe (1) moves between the shrouded retracted position relative to the housing (2) and the extended injecting position relative to the housing (2).
20. The injection device as claimed in claim 16, wherein the plunger (7) is molded integrally.
21. An injection device comprising a housing (2);
a syringe (1) slideably mounted within the housing for movement between a shrouded retracted position relative to the housing and an extended injecting position relative to the housing;
a bung (4) slideably mounted in the syringe and moveable to expel a liquid dose through a needle at a distal end of the syringe;
a plunger (7) having an end operable to move the bung (11) and to transmit an expulsion force thereto and having at least one integrally formed collapsible projecting region (10), the collapsible projecting region (10) comprising two flexible elbows projecting beyond the normal circumference of the plunger (7) but compressible into the circumference, the flexible elbows being a pair of arms on either side of a longitudinal slit provided between upper and lower solid portions of the plunger (7) and centrally located within an outer surface of the plunger (7), wherein the flexible elbows of the collapsible projecting region (10) project beyond the normal circumference of the plunger (7) prior to the collapsible projecting region (10) entering the syringe (1), and wherein the flexible elbows of the collapsible projecting region (10) are compressed into the normal circumference of the plunger (7) when the collapsible projecting region (10) enters the syringe (1) for applying the expulsion force to the bung (11) to expel the liquid dose from the syringe (1); and a bias spring (8) operable to move the plunger (7) in order to drive the syringe (1) from the shrouded retracted position relative to the housing (2) to the extended injecting position relative to the housing (2).
22. The injection device as claimed in claim 21, further comprising:
a return bias member (9) acting between the housing (2) and a proximal end (6) of the syringe (1) to hold the syringe (1) retracted in the shrouded retracted position relative to the housing (2) until the bias spring (8) is released.
23. The injection device as claimed in claim 22, wherein the bias spring (8) and/or the return bias member (9) provided within the housing is in the form of a coil spring.
24. The injection device as claimed in claim 21, wherein further movement of the syringe (1) is arrested when a proximal enlarged end of the syringe (1) abuts a proximal end (6) of the housing (2).
25. The injection device as claimed in claim 21, wherein the compression of the flexible elbows of the collapsible projecting region (10) into the normal circumference of the plunger (7) is caused by a continual bias exerted by the bias spring (8) as the collapsible projecting region (10) enters the syringe (1).
26. An injection device, comprising a housing (2);

a syringe (1) coupled to a needle at one end, the syringe (1) slideably mounted within the housing (2) for movement between a first position relative to the housing (2) in which the needle (5) is shrouded by the housing (2) and a second position relative to the housing (2) in which the needle (5) projects from the housing (2);
a bung (4) slideably mounted in the syringe (1) and moveable to expel a liquid through the needle (5);
a plunger (7) comprising:
an upper solid portion, a lower solid portion having one end operable to move the bung and to transmit an expulsion force thereto, and a projecting region (10) comprising one or more flexible elbows on either side of a central void provided between the upper and lower solid portions of the plunger (7), the plunger (7) having a first length when the projecting region (10) is in a projecting position in which the one or more elbows project outwardly from the central void, the plunger (7) having a second length greater than the first length when the projecting region (10) is in a collapsed position in which the one or more elbows are collapsed inwardly toward the central void; and an actuating bias member (8) provided at one end of the housing (2) and operable to move the plunger (7) toward another end of the housing (2).
27. The injection device as claimed in claim 26, wherein the projecting region (10) of the plunger (7) is configured to drive the syringe (1) from the first position relative to the housing (2) to the second position relative to the housing (2) such that the needle (5) projects from the housing (2).
28. The injection device as claimed in claim 26, wherein the projecting region (10) of the plunger (7) is in the projecting position prior to entering the syringe (1) and wherein the projecting region (10) is in the collapsed position inside the syringe (1) for applying the expulsion force to the bung in order to compress the liquid in the syringe (1) and cause expression of the liquid from the syringe (1), wherein a collapsing movement of the projecting region (10) toward the central void from the projecting position outside the syringe (1) to the collapsed position inside the syringe (1) causes elongation in the length of the plunger (7) from the first length to the second length.
29. The injection device as claimed in claim 26, wherein the central void is a longitudinally extending slit.
30. The injection device as claimed in claim 26, further comprising:
a return bias member (9) acting between the housing (2) and another end of the syringe (1) to hold the syringe (1) in the first position relative to the housing (2) until the actuating bias member (8) is released.
31. The injection device as claimed in claim 30, wherein the actuating bias member (8) and/or the return bias member (9) provided within the housing (2) is in the form of a coil spring.
32. The injection device as claimed in claim 26, wherein the housing (2) is fixed relative to the syringe (1).
33. The injection device as claimed in claim 26, wherein the plunger (7) is molded integrally.
34. A syringe assembly, comprising:
a syringe (1) coupled to a needle at one end, the syringe (1) slideably mounted within a housing (2) for movement between a first position relative to the housing (2) in which the needle (5) is shrouded by the housing (2) and a second position relative to the housing (2) in which the needle (5) projects from the housing (2);
a bung (4) slideably mounted in the syringe (1); and a plunger (7) comprising:
an upper solid portion, a lower solid portion having one end operable to move the bung (4) and to transmit an expulsion force thereto, and a projecting region (10) comprising one or more flexible elbows on either side of a central void provided between the upper and lower solid portions of the plunger (7), the plunger (7) having a first length when the projecting region (10) is in a projecting position in which the one or more elbows project outwardly from the central void, the plunger (7) having a second length greater than the first length when the projecting region (10) is in a collapsed position in which the one or more elbows are collapsed inwardly toward the central void.
35. The syringe assembly as claimed in claim 33, wherein the projecting region (10) of the plunger (7) is configured to drive the syringe (1) from the first position relative to the housing (2) to the second position relative to the housing (2) such that the needle (5) projects from the housing (2).
36. The syringe assembly as claimed in claim 33, wherein the projecting region (10) of the plunger (7) is in the projecting position prior to entering the syringe (1) and wherein the projecting region (10) is in the collapsed position inside the syringe (1) for applying the expulsion force to the bung (4), wherein a collapsing movement of the projecting region (10) toward the central void from the projecting position outside the syringe (1) to the collapsed position inside the syringe (1) causes elongation in the length of the plunger (7) from the first length to the second length.
37. The syringe assembly as claimed in claim 33, wherein the central void is a longitudinally extending slit.
38. The syringe assembly as claimed in claim 33, wherein the housing (2) is fixed relative to the syringe (1).
39. The syringe assembly as claimed in claim 33, wherein the plunger (7) is molded integrally.
CA 2571571 2004-06-23 2005-06-23 Improvements relating to automatic injection devices Expired - Fee Related CA2571571C (en)

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Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3993169B2 (en) 2002-02-11 2007-10-17 アンタレス・ファーマ・インコーポレーテッド Intradermal syringe
US20090204076A1 (en) * 2003-02-03 2009-08-13 Barry Peter Liversidge Medical Injector
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
GB2453069B (en) 2004-11-22 2009-12-09 Intelliject Llc Devices,systems and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
DK1850892T4 (en) 2005-01-24 2023-06-06 Antares Pharma Inc Prefilled needle-assisted syringe injector
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8226610B2 (en) 2005-02-01 2012-07-24 Intelliject, Inc. Medical injector with compliance tracking and monitoring
CN101111281B (en) 2005-02-01 2013-02-06 因特利杰克特有限公司 Devices, systems, and methods for medicament delivery
US8113244B2 (en) 2006-02-09 2012-02-14 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
CA2536845C (en) * 2006-02-16 2009-10-27 Pka Softtouch Corp. Drug delivery device
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
CA2651992A1 (en) 2006-06-30 2008-01-10 Abbott Biotechnology Ltd. Automatic injection device
US8814834B2 (en) 2008-03-10 2014-08-26 Antares Pharma, Inc. Injector safety device
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
US8075517B2 (en) * 2008-06-11 2011-12-13 Shl Group Ab Medicament delivery device
EP2318075B1 (en) 2008-08-05 2019-05-22 Antares Pharma, Inc. Multiple dosage injector
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
AU2010217760B2 (en) 2009-02-27 2015-04-09 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
CA2755779C (en) 2009-03-20 2015-11-10 Antares Pharma, Inc. Hazardous agent injection system
CA2760237C (en) 2009-04-29 2017-11-14 Abbott Biotechnology Ltd. Automatic injection device and plunger for same
GB0910681D0 (en) * 2009-06-19 2009-08-05 Ucb Pharma Sa Auto-injector
CA2769030C (en) 2009-07-30 2016-05-10 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US20110046559A1 (en) * 2009-08-21 2011-02-24 Becton Dickinson France S.A.S. Syringe Assembly Having a Flexible or Slidable Flange
KR101780210B1 (en) 2009-12-15 2017-09-21 애브비 바이오테크놀로지 리미티드 Improved firing button for automatic injection device
MX339532B (en) 2010-04-21 2016-05-30 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents.
ES2710905T3 (en) 2011-01-24 2019-04-29 E3D Agricultural Coop Association Ltd Injector
US8708968B2 (en) 2011-01-24 2014-04-29 Abbvie Biotechnology Ltd. Removal of needle shields from syringes and automatic injection devices
EP2749305B1 (en) 2011-01-24 2017-11-01 AbbVie Biotechnology Ltd Automatic injection devices having overmolded gripping surfaces
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US10357608B2 (en) * 2011-09-09 2019-07-23 Merck Patent Gmbh Re-loadable auto injector
JP6208136B2 (en) 2011-09-22 2017-10-04 アッヴィ・インコーポレイテッド Automatic injection equipment
PL2758101T3 (en) 2011-09-22 2016-05-31 Abbvie Inc Automatic injection device
PT2822618T (en) 2012-03-06 2024-03-04 Antares Pharma Inc Prefilled syringe with breakaway force feature
JP5855522B2 (en) * 2012-04-27 2016-02-09 株式会社吉野工業所 Metered syringe type ejector
EP2833944A4 (en) 2012-04-06 2016-05-25 Antares Pharma Inc Needle assisted jet injection administration of testosterone compositions
WO2013169800A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
EP2698180A1 (en) 2012-08-15 2014-02-19 Sanofi-Aventis Deutschland GmbH Autoinjector
WO2014083849A1 (en) * 2012-11-30 2014-06-05 株式会社吉野工業所 Metered syringe-type ejector
EP2938376A4 (en) 2012-12-27 2017-01-25 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
PT2953667T (en) 2013-02-11 2020-01-28 Antares Pharma Inc Needle assisted jet injection device having reduced trigger force
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
EP2902061A1 (en) * 2014-01-30 2015-08-05 Sanofi-Aventis Deutschland GmbH Medicament delivery device
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
KR101628349B1 (en) * 2014-12-03 2016-06-08 김준호 Auto-medicator of syringe interchange type
JP6573761B2 (en) * 2015-01-06 2019-09-11 小林製薬株式会社 Extrusion equipment
EP3258995A4 (en) 2015-02-20 2018-12-12 Regeneron Pharmaceuticals, Inc. Syringe systems, piston seal systems, stopper systems, and methods of use and assembly
US10695495B2 (en) 2015-03-24 2020-06-30 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
US10576206B2 (en) 2015-06-30 2020-03-03 Kaleo, Inc. Auto-injectors for administration of a medicament within a prefilled syringe
US10279123B2 (en) * 2015-10-01 2019-05-07 Noble International, Inc. Microcartridge
KR101705050B1 (en) * 2015-10-15 2017-02-09 (주)풍림파마텍 Automatic injecting apparatus for filler
USD818587S1 (en) 2016-03-29 2018-05-22 Abbevie Inc. Automatic injection device
US20180015224A1 (en) 2016-07-13 2018-01-18 California Institute Of Technology Dampers and Methods for Performing Measurements in an Autoinjector
US10688244B2 (en) 2016-12-23 2020-06-23 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
JP2020507841A (en) 2017-01-17 2020-03-12 カレオ，インコーポレイテッド Drug delivery device with wireless connection and event detection
US11929160B2 (en) 2018-07-16 2024-03-12 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
JP2022543523A (en) 2019-08-09 2022-10-13 カレオ，インコーポレイテッド Device and method for delivery of substances in pre-filled syringes
CN114748778A (en) * 2021-01-11 2022-07-15 苏州纳生微电子有限公司 Transmission structure, liquid feeding device applying transmission structure and using method of liquid feeding device
CN114917449B (en) * 2022-05-26 2024-02-27 曹清香 Adjustable-dosage local anesthesia equipment for anesthesia department

Family Cites Families (512)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2459875A (en) 1944-09-11 1949-01-25 Marvin L Folkman Syringe and ampoule
US2398544A (en) 1945-01-06 1946-04-16 Marshall L Lockhart Hypodermic injector
US2565081A (en) 1948-09-15 1951-08-21 Emma C Maynes Device for operating hypodermic syringes
US2591457A (en) 1948-09-15 1952-04-01 Emma C Maynes Syringe operating device
FR1078911A (en) 1949-08-17 1954-11-24 Automatic hypodermic syringe and its ampoule
US2701566A (en) 1950-02-07 1955-02-08 Becton Dickinson Co Injection apparatus
BE531562A (en) * 1953-09-02
US2960087A (en) 1954-02-16 1960-11-15 Auguste Rooseboom Hypodermic injection apparatus
DK97966C (en) 1954-10-27 1964-02-10 Astra Apotekarnes Kem Fab Syringe.
US3055362A (en) 1956-05-16 1962-09-25 Auguste Rooseboom Hypodermic injection apparatus
NL106573C (en) 1957-05-31
US2888924A (en) 1958-02-25 1959-06-02 Russell P Dunmire Hypodermic syringes
US3051173A (en) 1960-05-12 1962-08-28 Alvin P Johnson Veterinary hypodermic syringe
US3330279A (en) 1963-10-18 1967-07-11 Sarnoff Automatic hypodermic syringe
US3314428A (en) 1963-12-04 1967-04-18 Alvin P Johnson Veterinary hypodermic syringe
US3403679A (en) 1964-12-11 1968-10-01 Secr Defence Brit Hypodermic injection apparatus with a secondary capsule-collapsing means
US3496937A (en) 1967-05-18 1970-02-24 John E Balson Hypodermic syringe
US3543603A (en) 1968-01-10 1970-12-01 Rex Chainbelt Inc Automatic quick release mechanism
US3541663A (en) 1968-08-21 1970-11-24 Roman Szpur Syringe needle attachment device
US3605743A (en) 1968-10-14 1971-09-20 Raul Olvera Arce Hypodermic syringe
DE1957833A1 (en) 1968-11-21 1970-07-02 Maurice Steiner Injection syringe, especially injection syringe handled by the patient himself
US3618603A (en) 1969-01-29 1971-11-09 Levenson M F Syringe
BE755224A (en) * 1969-08-25 1971-02-24 Philips Nv INJECTION SYRINGE
JPS5014835Y1 (en) 1969-11-18 1975-05-09
DE2019296A1 (en) 1970-04-22 1971-11-04 Walter Dr Stein Injection device, in particular injection syringe with portioned pack
US3712301A (en) 1971-01-11 1973-01-23 Survival Technology Gun type hypodermic injector with rapid cartridge displacement within holder
BE795162A (en) * 1972-02-10 1973-08-08 Philips Nv INJEKTIE-INRICHTING
US3910260A (en) 1972-03-01 1975-10-07 Survival Technology Method and apparatus of treating heart attack patients prior to the establishment of qualified direct contact personal care
US3797488A (en) 1972-07-10 1974-03-19 Ampoules Inc Ampoule applicator with one-way clutch
US4004577A (en) 1972-12-04 1977-01-25 Survival Technology, Inc. Method of treating heart attack patients prior to the establishment of qualified direct contact personal care
JPS5014835A (en) 1973-06-18 1975-02-17
FR2237643B1 (en) 1973-07-17 1978-03-17 Steiner Maurice
US3882863A (en) 1973-08-01 1975-05-13 Survival Technology Hypodermic injection device having cannula covered with resilient sheath
US3941130A (en) 1975-03-18 1976-03-02 Tibbs Robert C Sequential trigger release for injection device
US4031893A (en) 1976-05-14 1977-06-28 Survival Technology, Inc. Hypodermic injection device having means for varying the medicament capacity thereof
US4106770A (en) 1976-09-01 1978-08-15 Gray John M Hypodermic syringe projectile
US4178928A (en) 1977-08-10 1979-12-18 Tischlinger Edward A Self injector
SU787035A1 (en) 1978-01-11 1980-12-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Device for injection of medical preparations
US4202314A (en) 1978-11-20 1980-05-13 Busygin Valery P Device for injection of medicinal preparations
US4226235A (en) 1979-01-25 1980-10-07 Survival Technology, Inc. Plural injecting device
US4258713A (en) 1979-07-23 1981-03-31 Wardlaw Stephen C Automatic disposable hypodermic syringe
US4261358A (en) 1979-10-01 1981-04-14 Walter Vargas Automatic syringe plunger
US4275729A (en) 1979-10-29 1981-06-30 Jules Silver Adjustable dosage syringe
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
AU549690B2 (en) 1981-06-29 1986-02-06 Sherwood Services Ag Pin prick device to pierce skin
DE3266681D1 (en) 1981-07-27 1985-11-07 Duphar Int Res Automatic injection syringe
US4437859A (en) 1981-08-03 1984-03-20 Drs Infusion Systems, Inc. Hydraulic syringe drive
US4394863A (en) 1981-10-23 1983-07-26 Survival Technology, Inc. Automatic injector with cartridge having separate sequentially injectable medicaments
US4425120A (en) 1982-04-15 1984-01-10 Sampson Norma A Shielded hypodermic syringe
EP0107874B1 (en) 1982-10-27 1986-11-26 Duphar International Research B.V Automatic injection device
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US4530695A (en) 1982-12-31 1985-07-23 N.J. Phillips Pty. Limited Injector
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4578064A (en) 1983-12-21 1986-03-25 Survival Technology Inc. Plural dosage automatic injector with improved safety
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US4619265A (en) 1984-03-08 1986-10-28 Physio-Control Corporation Interactive portable defibrillator including ECG detection circuit
US4610254A (en) 1984-03-08 1986-09-09 Physio-Control Corporation Interactive portable defibrillator
US4573976A (en) 1984-05-24 1986-03-04 Dolores A. Smith Shielded needle
US4636202A (en) * 1984-07-27 1987-01-13 Syntex (U.S.A.) Inc. Medicament applicator with plunger assembly and automatically-openable closure therefor
US4795433A (en) 1985-05-20 1989-01-03 Survival Technology, Inc. Automatic injector for emergency treatment
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4678461A (en) 1984-11-01 1987-07-07 Survival Technology, Inc. Automatic injector with improved glass container protector
DE3566866D1 (en) 1984-11-02 1989-01-26 Duphar Int Res Automatic injection device
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4627445A (en) 1985-04-08 1986-12-09 Garid, Inc. Glucose medical monitoring system
US4689042A (en) 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4723937A (en) 1985-05-20 1988-02-09 Survival Technology, Inc. Plural dosage automatic injector with a by-pass fitment
EP0242373A1 (en) 1985-10-11 1987-10-28 Physionic Gesellschaft Für Medizin- Und Systemtechnik Gmbh Injection syringe
ATE55260T1 (en) 1985-10-11 1990-08-15 Duphar Int Res AUTOMATIC SYRINGE.
AU606320B2 (en) 1985-11-01 1991-02-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US4640686A (en) 1986-02-24 1987-02-03 Survival Technology, Inc. Audible signal autoinjector training device
US4664653A (en) 1986-02-24 1987-05-12 Sagstetter William E Manually operated reusable injection apparatus
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP0245895B1 (en) 1986-05-15 1991-09-18 Duphar International Research B.V Automatic injector
DE3631229A1 (en) 1986-09-13 1988-03-24 Basf Ag MONOCLONAL ANTIBODIES AGAINST HUMAN TUMORNESCROSE FACTOR (TNF) AND THEIR USE
DE3645245C2 (en) 1986-11-14 1994-01-27 Haselmeier Wilhelm Fa Injection appliance
US4795432A (en) 1987-02-19 1989-01-03 Karczmer Claude M Shield assembly for hypodermic injection devices
DE3709783C1 (en) 1987-03-25 1988-04-14 Blendax Werke Schneider Co Dosing syringe
DE3715258C2 (en) 1987-05-08 1996-10-31 Haselmeier Wilhelm Fa Injection device
DE3715340C2 (en) 1987-05-08 1995-10-19 Haselmeier Wilhelm Fa Injection device
US4927416A (en) 1987-12-02 1990-05-22 National Medical Device Corporation User-protective hypodermic syringe holder
GB8809115D0 (en) 1988-04-18 1988-05-18 Turner R C Syringes
JPH025504A (en) 1988-06-24 1990-01-10 Matsushita Electric Ind Co Ltd Voltage non-linear resistor
EP0404954B1 (en) 1988-07-28 2002-10-02 Idemitsu Petrochemical Co., Ltd. Rubber-modified styrene resin composition
GB8819977D0 (en) 1988-08-23 1988-09-21 Medimech Ltd Automatic injectors
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US4902279A (en) 1988-10-05 1990-02-20 Autoject Systems Inc. Liquid medicament safety injector
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
US4929237A (en) 1988-11-07 1990-05-29 David Medway Hypodermic needle protection device
US4955868A (en) 1988-11-28 1990-09-11 Edward Klein Disposable safety medical syringe
IT1227658B (en) 1988-12-01 1991-04-23 Vittorio Boschetti B DISPOSABLE SYRINGE WITH RETURN AND NEEDLE LOCK AT THE END OF INJECTION FOR THE PURPOSE OF AVOID RE-USE
JP2989002B2 (en) 1988-12-22 1999-12-13 キリン―アムジエン・インコーポレーテツド Chemically modified granulocyte colony stimulating factor
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
ES2019792A6 (en) 1990-01-17 1991-07-01 Caralt Batlle Jaime Disposable hypodermic syringe.
ES2009709A6 (en) 1989-01-24 1989-10-01 Villar Pascual Jose Antonio Single-use safety syringe
US4923447A (en) 1989-02-17 1990-05-08 Morgan Michael W Syringe assembly
DK0390244T3 (en) 1989-03-28 1993-02-08 Duphar Int Res Pre-filled injection device comprising a cylinder in which a liquid diazepam formulation is included
US4966592A (en) 1989-05-05 1990-10-30 Burns Cameron A Protective sleeve for hypodermic needle
USD322479S (en) 1989-06-02 1991-12-17 Terumo Kabushiki Kaisha Holder for lancet
US4994034A (en) 1989-07-11 1991-02-19 Botich Michael J Retractable needle hypodermic syringe system
US5407431A (en) 1989-07-11 1995-04-18 Med-Design Inc. Intravenous catheter insertion device with retractable needle
US5085642A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5102393A (en) 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US5085641A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use auto-injector with improved cap structure
US6498237B2 (en) 1989-08-07 2002-12-24 Peptech Limited Tumor necrosis factor antibodies
US5959087A (en) 1989-08-07 1999-09-28 Peptide Technology, Ltd. Tumour necrosis factor binding ligands
CA2485553A1 (en) 1989-09-05 1991-03-21 Immunex Corporation Tumor necrosis factor - .alpha. and - .beta. receptors
CN2077717U (en) * 1989-10-05 1991-05-29 薛建仁 One-shot medical use perfusion bottle and perfusion controller
EP0423864A1 (en) 1989-10-16 1991-04-24 Duphar International Research B.V Training device for an automatic injector
GB8926825D0 (en) 1989-11-28 1990-01-17 Glaxo Group Ltd Device
ES2074168T3 (en) 1990-03-08 1995-09-01 Blue Star Corp Sa SELF-SWEEPING NEEDLE SYRINGE.
GB2243552A (en) 1990-03-21 1991-11-06 Transfertec Limited Improvements in or relating to single-use syringes
US5092843A (en) 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
AU665190B2 (en) 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE129906T1 (en) 1990-07-19 1995-11-15 Nardino Righi SINGLE USE SAFETY SYRINGE.
DK285990A (en) 1990-11-30 1992-05-31 Nujenko Pty Ltd SPRAY UNIT
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
AU114410S (en) 1990-12-21 1992-06-29 Glaxo Group Ltd An injector
GB9100819D0 (en) * 1991-01-15 1991-02-27 Medimech Int Ltd Subcutaneous injector
US5376080A (en) 1991-01-30 1994-12-27 Petrussa; Gian L. Single use retractable needle syringe
ATE439435T1 (en) 1991-03-01 2009-08-15 Dyax Corp CHIMERIC PROTEIN COMPRISING MICROPROTEIN HAVING TWO OR MORE DISULFIDE BONDS AND FORMATIONS THEREOF
US5656272A (en) 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
JP3672306B2 (en) 1991-04-10 2005-07-20 ザ スクリップス リサーチ インスティテュート Heterodimeric receptor library using phagemids
CN2094999U (en) * 1991-04-13 1992-02-05 张卫 Automatic syringe
GB9111600D0 (en) * 1991-05-30 1991-07-24 Owen Mumford Ltd Improvements relating to injection devices
EP0518416A1 (en) 1991-06-13 1992-12-16 Duphar International Research B.V Injection device
RU2004256C1 (en) 1991-06-26 1993-12-15 Липов Борис Петрович, Сафронов Игорь Николаевич Injector
DE4122599C2 (en) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid for screening antibodies
EP0525525B1 (en) 1991-07-24 1995-05-03 Medico Development Investment Company Injector
US5259840A (en) 1991-09-03 1993-11-09 Boris Craig R Locking syringe
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
US5242240A (en) 1991-10-17 1993-09-07 Minnesota Scientific, Inc. Clamping device for a surgical retractor
USD346219S (en) 1991-11-25 1994-04-19 Actimed Plast AB Erection pump
US5263934A (en) 1991-11-28 1993-11-23 Haak Abraham Van Den Stroke limiting syringe with retractable needle
DK194291D0 (en) 1991-11-29 1991-11-29 Novo Nordisk As SPRAY FOR AUTOMATIC INJECTION.
WO1993013819A1 (en) 1992-01-07 1993-07-22 Sti International Limited Automatic injectors
GB9200219D0 (en) 1992-01-07 1992-02-26 Medimech Int Ltd Automatic injectors
AT398037B (en) 1992-01-10 1994-08-25 Med Plastic Ag DEVICE FOR SELF-INJECTION
US5201708A (en) 1992-02-03 1993-04-13 Timothy A. Kershenstine Self-locking safety syringe
DE69302852T2 (en) 1992-03-27 1996-09-26 Duphar Int Res Automatic syringe
DE69331265T2 (en) 1992-04-02 2002-08-08 Smithkline Beecham Corp COMPOUNDS FOR TREATING INFLAMMABLE DISEASES AND INHIBITING THE PRODUCTION OF TUMORNESCROSE FACTOR
US5267972A (en) 1992-07-20 1993-12-07 Anderson Wayne W Hypodermic syringe with needle guard
US5267963A (en) 1992-08-21 1993-12-07 Nicholas Bachynsky Medication injection device
KR100232688B1 (en) 1992-09-15 1999-12-01 스코트 쥐. 홀퀴스트 Pharmaceutical compositions for treating tnf-dependent inflammation using tumor necrosis factor antagonists
GB9219849D0 (en) 1992-09-19 1992-10-28 Hypoguard Uk Ltd Device
WO1994008609A1 (en) 1992-10-15 1994-04-28 Dana-Farber Cancer Institute, Inc. TREATMENT OF INSULIN RESISTANCE IN OBESITY LINKED TYPE II DIABETES USING ANTAGONISTS TO TNF-α FUNCTION
US5224936A (en) 1992-10-15 1993-07-06 Brian Gallagher Automatic self-protecting hypodermic needle assembly
US5295975A (en) 1992-10-28 1994-03-22 Lockwood Jr Hanford N Hypodermic needle safety device with sliding outer cover
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
GB9223183D0 (en) 1992-11-05 1992-12-16 Medimech Int Ltd Improvements related to auto injectors
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US5681291A (en) 1992-11-19 1997-10-28 Tebro S.A. Disposable auto-injector for prefilled syringes
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
IT1256577B (en) 1992-12-11 1995-12-11 Ermanno Greco DEVICE PREPARED FOR THE AUTOMATIC ADMINISTRATION OF A DRUG VIA INTRADERMIC.
US5346480A (en) 1992-12-14 1994-09-13 Q-Med, Inc. Syringe with retractable needle
US5298024A (en) 1992-12-28 1994-03-29 Frank Richmond Multi-liquid medicament delivery system with reflex valves
FR2701211B1 (en) 1993-02-08 1995-05-24 Aguettant Lab DOSING INSTRUMENT, ESPECIALLY INJECTION
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
EP0693946B1 (en) 1993-03-24 2001-05-16 Owen Mumford Limited Improvements relating to injection devices
DK55693D0 (en) 1993-05-13 1993-05-13 Radiometer As SHOOTING MECHANISM FOR SHOOTING A CANNEL LOCATED IN CONNECTION WITH A CONTAINER, AND A CONTAINER TOPIC INCLUDING SUCH A SHOOTING MECHANISM
US5540664A (en) 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5358489A (en) 1993-05-27 1994-10-25 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5433712A (en) 1993-06-10 1995-07-18 Donald E. Stiles Self-sheathing hypodermic syringe
US5425715A (en) 1993-08-05 1995-06-20 Survival Technology, Inc. Reloadable injector
US5620421A (en) * 1993-12-09 1997-04-15 Schmitz; William L. Syringe injector system
FR2715071B1 (en) 1994-01-17 1996-03-01 Aguettant Lab Automatic drug injector.
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
JP4201345B2 (en) 1994-05-30 2008-12-24 ビィ ディ メディコ ソシエタ ア レスポンサビリタ リミタータ Injection device
GB9412301D0 (en) 1994-06-17 1994-08-10 Safe T Ltd Hollow-needle drugs etc applicators
US5645534A (en) 1994-06-24 1997-07-08 Becton Dickinson And Company Time of last injection indicator for medication delivery pen
JP3687975B2 (en) 1994-07-01 2005-08-24 エドワーズ ライフサイエンシーズ コーポレイション Method for collecting adipose tissue containing autologous microvascular endothelial cells
CN2224628Y (en) * 1994-10-26 1996-04-17 周正龙 Automatic syringe with dual springs
US5637094A (en) 1994-11-04 1997-06-10 Pos-T-Vac, Inc. Multiple dosage syringe
RU2069584C1 (en) 1994-11-24 1996-11-27 Виктор Владимирович Барелко Catalyst for chemical processes, in particular, for conversion of ammonia, oxidation of hydrocarbons, sulfur dioxide, and for purification of gases
US5993421A (en) 1994-12-02 1999-11-30 Science Incorporated Medicament dispenser
GB9504878D0 (en) 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator
US6319011B1 (en) 1995-04-06 2001-11-20 Michael J. Motti Automatic training defibrillator simulator and method
FR2733155B1 (en) 1995-04-18 1997-09-19 Tebro RECHARGEABLE SELF-INJECTOR
FR2736553B1 (en) * 1995-07-12 1998-01-09 Soc Et Et D Applic Tech Sedat INJECTION SYRINGE, IN PARTICULAR LIQUID MEDICAL PRODUCTS, WITH MOBILE NEEDLE PROTECTOR
US5797969A (en) 1995-08-01 1998-08-25 Survivalink Corporation One button lid activated automatic external defibrillator
US5645571B1 (en) 1995-08-01 1999-08-24 Surviva Link Corp Automated external defibrillator with lid activated self-test system
EP1637181A1 (en) 1995-08-08 2006-03-22 Cardiac Science, Inc. Automated external defibrillator
US5591138A (en) 1995-08-10 1997-01-07 Vaillancourt; Vincent L. Protected needle assembly
US5735818A (en) 1995-10-11 1998-04-07 Science Incorporated Fluid delivery device with conformable ullage
US5658259A (en) 1995-10-19 1997-08-19 Meridian Medical Technologies, Inc. Dental cartridge assembly auto-injector with protective needle cover
US5567160A (en) 1995-10-26 1996-10-22 Survival Technology, Inc. Autoinjector training device
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US5807335A (en) 1995-12-22 1998-09-15 Science Incorporated Fluid delivery device with conformable ullage and fill assembly
US5634906A (en) 1995-12-27 1997-06-03 Habley Medical Technology Corporation Needle hiding shield for a dose metering syringe
SK284040B6 (en) 1996-02-09 2004-08-03 Abbott Laboratories (Bermuda) Ltd. Human antibodies that bind human TNFalpha
DE19604838A1 (en) 1996-02-12 1997-08-14 Alfred Von Schuckmann Device for dispensing liquid in divided quantities
ATE494027T1 (en) 1996-03-12 2011-01-15 Novo Nordisk As INJECTION DEVICE WITH ELECTRONIC DISPLAY OF THE SELECTED DOSE
US5817111A (en) 1996-03-28 1998-10-06 Riza; Erol D. Open loop suture snare
IT1284642B1 (en) 1996-05-02 1998-05-21 Ermanno Greco REFINEMENTS FOR AUTOMATIC SYRINGES FOR INJECTION
EP1579814A3 (en) 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
GB9612724D0 (en) 1996-06-18 1996-08-21 Owen Mumford Ltd Improvements relating to injection devices
WO1998001172A1 (en) 1996-07-05 1998-01-15 Disetronic Licensing Ag Injection device for injection of liquid
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US6325066B1 (en) 1996-08-26 2001-12-04 Charles B. Hughes Bladder and bowel training system with removable voice module system
US5845644A (en) 1996-08-26 1998-12-08 Hughes; Charles B. Bladder and bowel training system
US6593456B1 (en) 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US6569664B1 (en) 1996-11-06 2003-05-27 The Regents Of The University Of California Native TNF receptor releasing enzyme
SE9604162D0 (en) 1996-11-13 1996-11-13 Astra Ab membrane
US6203530B1 (en) 1997-01-28 2001-03-20 Pos-T-Vac, Inc. Auto-injection device
US20070142776A9 (en) * 1997-02-05 2007-06-21 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
BR9700930A (en) 1997-02-07 1998-12-08 Rhone Poulenc Rorer Gmbh Unit for sale intended for parenteral application a device for the execution of parenteral application as well as a refill unit for the above mentioned unit for sale
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US6319234B1 (en) 1997-02-12 2001-11-20 Sergio Restelli Disposable safety syringe
DE29703820U1 (en) 1997-03-03 1998-07-02 Medico Dev Investment Co Injection device
US20010020155A1 (en) 1997-03-25 2001-09-06 Soren Mikkelsen Injection system
US6454746B1 (en) 1997-06-04 2002-09-24 Eli Lilly And Company Medication delivery apparatus
US6500150B1 (en) 1997-06-16 2002-12-31 Elan Pharma International Limited Pre-filled drug-delivery device and method of manufacture and assembly of same
US6979307B2 (en) 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
GB9714948D0 (en) 1997-07-16 1997-09-17 Owen Mumford Ltd Improvements relating to injection devices
GB9716065D0 (en) 1997-07-31 1997-10-01 Owen Mumford Ltd Improvements relating to injection devices
IL134415A (en) 1997-08-21 2004-01-04 Ares Trading Sa Injection devices
US5931817A (en) 1997-09-12 1999-08-03 Becton Dickinson And Company Pen needle assembly
JP3968445B2 (en) * 1997-09-16 2007-08-29 株式会社アルテ Prefilled syringe
WO1999016485A1 (en) 1997-09-29 1999-04-08 Becton Dickinson And Company Injection device and drug cartridge for preventing cross-use of the device and drug cartridge
US6149626A (en) 1997-10-03 2000-11-21 Bachynsky; Nicholas Automatic injecting syringe apparatus
WO1999022792A1 (en) 1997-11-03 1999-05-14 Ermanno Greco Self-injection device
FR2770404B1 (en) 1997-11-05 2000-01-28 Sedat AUTOMATIC INJECTOR WITH NEEDLE RETRACTION AT THE END OF INJECTION
DE69827036T2 (en) 1997-12-16 2006-03-09 Meridian Medical Technologies, Inc. AUTOMATIC INJECTION DEVICE FOR THE ADMINISTRATION OF A MEDICAMENT
IT1304761B1 (en) 1998-01-20 2001-03-29 Nardino Righi DISPOSABLE SAFETY SYRINGE.
DE29801168U1 (en) 1998-01-24 1999-08-12 Medico Dev Investment Co Injection device
FR2774294B1 (en) 1998-02-04 2000-04-14 Marc Brunel DEVICE FOR AUTOMATICALLY INJECTING A DOSE OF MEDICINAL PRODUCT
US7056306B1 (en) 1998-02-05 2006-06-06 Mdc Investment Holdings, Inc. Fluid sampling device with retractable needle
GB9803084D0 (en) 1998-02-14 1998-04-08 Owen Mumford Ltd Improvements relating to medical injection devices
FI109272B (en) 1998-02-26 2002-06-28 Raimo Juselius Intake event detector and method for detecting intake event
US6319233B1 (en) 1998-04-17 2001-11-20 Becton, Dickinson And Company Safety shield system for prefilled syringes
GB9808408D0 (en) 1998-04-18 1998-06-17 Owen Mumford Ltd Improvements relating to injection devices
DE19821933C1 (en) 1998-05-15 1999-11-11 Disetronic Licensing Ag Device for administering an injectable product
DE19822031C2 (en) 1998-05-15 2000-03-23 Disetronic Licensing Ag Auto injection device
USD428651S (en) 1998-10-26 2000-07-25 Pharmacia & Upjohn Ab Autoinjector for standardized single dose syringes
SE9803662D0 (en) * 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab autoinjector
US6125299A (en) 1998-10-29 2000-09-26 Survivalink Corporation AED with force sensor
US6059756A (en) * 1998-11-04 2000-05-09 Yeh; Song-Hwa Safety injection device
CA2350706A1 (en) 1998-11-13 2000-05-25 Elan Pharma International Limited Drug delivery systems and methods
US20060058848A1 (en) 1998-11-20 2006-03-16 Medtronic Emergency Response Systems, Inc. AED with user inputs in response to prompts
WO2000030712A1 (en) 1998-11-20 2000-06-02 Medtronic Physio-Control Manufacturing Corp. Visual and aural user interface for an automated external defibrillator
US6312412B1 (en) 1998-12-02 2001-11-06 V. C. Saied, M.D. Apparatus and method for painless intramuscular or subcutaneous injections
US6872080B2 (en) 1999-01-29 2005-03-29 Cardiac Science, Inc. Programmable AED-CPR training device
GB9903475D0 (en) 1999-02-17 1999-04-07 Owen Mumford Ltd Improvements relating to injection devices
US6743203B1 (en) 1999-07-27 2004-06-01 Pharma Consult Ges.M.B.H. Device for automatically injecting injection liquids
US6213987B1 (en) 1999-08-02 2001-04-10 Michael N. Hirsch Shroud for a used hypodermic syringe needle
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
ATE282451T1 (en) 1999-09-07 2004-12-15 Controlled Syringe Inc Comp RETRACTABLE NEEDLE ASSEMBLY
US6102896A (en) 1999-09-08 2000-08-15 Cambridge Biostability Limited Disposable injector device
US7011650B2 (en) * 1999-09-09 2006-03-14 Paradigm Medical, Llc Multiple-dose syringe with collapsible container
US20020091361A1 (en) * 1999-09-09 2002-07-11 Rosoff Jack P. Multiple-dose syringe
EP1257307A2 (en) 1999-09-13 2002-11-20 Vitro Diagnostics, Inc. Multi-dose syringe driver
US6171285B1 (en) 1999-10-06 2001-01-09 R. Steven Johnson Retractable syringe
US6673035B1 (en) 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
DE60042856D1 (en) 1999-11-18 2009-10-08 Tyco Healthcare Automatic safety needle guard
GB9927715D0 (en) 1999-11-24 2000-01-19 Safe T Ltd Hollow-needle devices
MXPA02005262A (en) 1999-11-29 2004-04-21 Mdc Invest Holdings Inc Combination safety needle assembly and medical apparatus.
US6970742B2 (en) 2000-01-11 2005-11-29 Savacor, Inc. Method for detecting, diagnosing, and treating cardiovascular disease
US8298150B2 (en) 2000-01-11 2012-10-30 Cedars-Sinai Medical Center Hemodynamic waveform-based diagnosis and treatment
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
RU2169584C1 (en) 2000-01-17 2001-06-27 Лисовой Дмитрий Григорьевич Injector
GB0003790D0 (en) 2000-02-18 2000-04-05 Astrazeneca Uk Ltd Medical device
AU4158401A (en) * 2000-02-23 2001-09-03 Abbott Lab Syringes and syringe systems for selectively dispensing controlled amounts of a therapeutic substance
DE10009815B4 (en) 2000-03-01 2009-07-16 Tecpharma Licensing Ag Injection device with a needle cover
DE10009814B4 (en) 2000-03-01 2008-03-06 Tecpharma Licensing Ag Disposable injector
US6322540B1 (en) 2000-03-10 2001-11-27 International Technology Group Safe needle device for syringe
US6475194B2 (en) 2000-04-05 2002-11-05 Gem Plastics, Inc. Safety syringe
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
USD461555S1 (en) 2000-05-25 2002-08-13 Jean Marc Binet Safety syringe
US6517517B1 (en) 2000-06-08 2003-02-11 Mayo Foundation For Medical Education And Research Automated injection device for administration of liquid medicament
JP2003534879A (en) 2000-06-08 2003-11-25 メリディアン メディカル テクノロジーズ，インコーポレイテッド Wet / dry automatic injection assembly
US6502699B1 (en) 2000-06-21 2003-01-07 Robert L. Watson Method and kit for making injections and withdrawing blood without the use of protective gloves
NO312059B1 (en) 2000-06-23 2002-03-11 Syringus As A cannula cover mechanism, a cannula holder and an injection syringe
MXPA03000670A (en) 2000-07-28 2004-11-01 Mdc Invest Holdings Inc Retractable needle medical device for injecting fluid from a pre-filled cartridge.
US6986760B2 (en) 2000-08-02 2006-01-17 Becton, Dickinson And Company Pen needle and safety shield system
UA81743C2 (en) 2000-08-07 2008-02-11 Центокор, Инк. HUMAN MONOCLONAL ANTIBODY WHICH SPECIFICALLY BINDS TUMOR NECROSIS FACTOR ALFA (TNFα), PHARMACEUTICAL MIXTURE CONTAINING THEREOF, AND METHOD FOR TREATING ARTHRITIS
AU2001281753A1 (en) 2000-08-29 2002-03-13 Novo-Nordisk A/S Automatic injection device with torsion function for retraction of needle
US6413237B1 (en) 2000-08-31 2002-07-02 Becton, Dickinson And Company Hypodermic syringe with selectively retractable needle
US6964647B1 (en) 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US6953445B2 (en) 2000-10-10 2005-10-11 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
FR2815543B1 (en) 2000-10-19 2003-10-24 Sedat SELF-INJECTION SYRINGE OF AN EXTEMPORANEOUS MIXTURE
US20040229854A1 (en) 2000-11-28 2004-11-18 Pieter Haan De Immediate release dosage form for HRT
SE518981C2 (en) 2000-12-14 2002-12-17 Shl Medical Ab autoinjector
US6387078B1 (en) 2000-12-21 2002-05-14 Gillespie, Iii Richard D. Automatic mixing and injecting apparatus
EP2325205A3 (en) 2000-12-28 2011-10-12 Altus Pharmaceuticals Inc. Crystals of whole antibodies and fragments thereof and methods for making and using them
USD453569S1 (en) 2001-01-08 2002-02-12 Pharmacia Ab Injection device
US6673049B2 (en) 2001-02-15 2004-01-06 Disetronic Licensing Ag Injection device for injecting fluid
AUPR373001A0 (en) 2001-03-14 2001-04-12 Glenord Pty Ltd Improved non-reusable syringe
BR0206160A (en) 2001-05-25 2004-10-26 Abbott Gmbh & Co Kg Use of anti-TNF antibodies as medicines in the treatment of septic disorders of anemic patients.
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US6802827B2 (en) 2001-06-26 2004-10-12 Stig O. Andersson Hypodermic implant device
GB0118419D0 (en) 2001-07-28 2001-09-19 Owen Mumford Ltd Improvements relating to injection devices
EP1281410A1 (en) 2001-08-03 2003-02-05 Sergio Restelli Automatic safety syringe
US7163943B2 (en) 2001-09-21 2007-01-16 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
FR2830765B1 (en) 2001-10-15 2004-07-23 Plastic Omnium Cie SAFETY DEVICE FOR A SYRINGE
US6494863B1 (en) 2001-10-15 2002-12-17 Retractable Technologies, Inc. One-use retracting syringe with positive needle retention
JP2003122442A (en) 2001-10-16 2003-04-25 Sony Corp Wireless data communications method and apparatus for software download system
US6796967B2 (en) 2001-10-22 2004-09-28 Nps Pharmaceuticals, Inc. Injection needle assembly
US7569035B1 (en) 2001-11-02 2009-08-04 Meridian Medical Technologies, Inc. Automatic injector with anti-coring needle
AUPR867901A0 (en) 2001-11-05 2001-11-29 University of Newcastel Research Associates Limited, The 'Liquid dispenser'
CN100363063C (en) 2001-11-09 2008-01-23 阿尔扎公司 Collapsible syringe cartridge
US20030105430A1 (en) 2001-11-30 2003-06-05 Elan Pharma International Limited Wil House Automatic injector
GB0200637D0 (en) 2002-01-12 2002-02-27 Dca Design Int Ltd Improvements in and relating to medicament injection apparatus
US6872194B2 (en) 2002-01-31 2005-03-29 Safety Syringes, Inc. Disposable self-shielding syringe guard
EP1334740A1 (en) 2002-02-11 2003-08-13 Sergio Restelli Glass safety syringe and relative safety kit for glass syringe
JP2005517500A (en) 2002-02-15 2005-06-16 アンタレス・ファーマ・インコーポレーテッド Syringe with bypass channel
US20030161828A1 (en) 2002-02-19 2003-08-28 Abbott Gmbh & Co. Kg Use of TNF antagonists as drugs for the treatment of patients with an inflammatory reaction and without suffering from total organ failure
US7033338B2 (en) 2002-02-28 2006-04-25 Smiths Medical Md, Inc. Cartridge and rod for axially loading medication pump
GB0205066D0 (en) 2002-03-05 2002-04-17 Owen Mumford Ltd Improvements relating to injection devices
AU2003208948A1 (en) 2002-03-13 2003-09-29 Eli Lilly And Company Method of treating a medical condition with a portable medication delivery device
CN101143221A (en) 2002-03-15 2008-03-19 布赖汉姆妇女医院 Central airway administration for systemic delivery of therapeutics
EP1487520A1 (en) 2002-03-18 2004-12-22 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
US20030187401A1 (en) 2002-03-27 2003-10-02 Safety Syringes, Inc. Syringe with integral safety system
US6976976B2 (en) 2002-03-27 2005-12-20 Safety Syringes, Inc. Syringe with needle guard injection device
US7004929B2 (en) 2002-03-29 2006-02-28 Mdc Investment Holdings, Inc. Safety pre-filled cartridge injector
AU2003221794A1 (en) * 2002-04-05 2003-11-17 Comar, Inc. Dispenser for medicaments and method and apparatus for making same
US20030206898A1 (en) 2002-04-26 2003-11-06 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
US20040009172A1 (en) 2002-04-26 2004-01-15 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
GB2388033A (en) * 2002-05-02 2003-11-05 Pa Consulting Services Automatic injection device
DK1503816T3 (en) 2002-05-02 2007-04-23 Pa Consulting Services injection device
US7247151B2 (en) 2002-05-09 2007-07-24 Adam Slawson Injector with shielded needle
US6808507B2 (en) 2002-05-10 2004-10-26 Cambridge Biostability Ltd. Safety injectors
US8527044B2 (en) 2002-05-15 2013-09-03 Physio-Control, Inc. User interface method and apparatus for a medical device
GB0211294D0 (en) 2002-05-17 2002-06-26 Owen Mumford Ltd Improvements relating to injection devices
US6979316B1 (en) 2002-05-23 2005-12-27 Seedlings Life Science Ventures Llc Apparatus and method for rapid auto-injection of medication
US20050171476A1 (en) 2002-05-24 2005-08-04 Judson Jared A. Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
WO2003103750A1 (en) 2002-06-05 2003-12-18 Elan Pharma International Limited Injector adapter and combination thereof
GB0214452D0 (en) 2002-06-22 2002-07-31 Liversidge Barry P Medical needle assemblies
US20100160869A1 (en) 2002-06-22 2010-06-24 Barry Peter Liversidge Medical Needle Assemblies
MY139059A (en) 2002-06-24 2009-08-28 Alza Corp Reusable, spring driven autoinjector
DE10229138B4 (en) 2002-06-28 2008-01-31 Tecpharma Licensing Ag Product diverter with piston rod emergency reset
EP3610909A1 (en) 2002-07-02 2020-02-19 PHC Holdings Corporation Automatic administration instrument for medical use
FR2842428B1 (en) 2002-07-19 2004-10-08 Becton Dickinson France DEVICE FOR INJECTING A PRODUCT, ESPECIALLY FOR MEDICAL USE
US20090280065A1 (en) 2006-04-10 2009-11-12 Willian Mary K Uses and Compositions for Treatment of Psoriasis
PL213925B1 (en) 2002-07-19 2013-05-31 Abbott Biotech Ltd Treatment of tnf ó related disorders
AU2003257994A1 (en) 2002-07-31 2004-02-16 Alza Corporation Injection device providing automatic needle retraction
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
US20040039337A1 (en) 2002-08-21 2004-02-26 Letzing Michael Alexander Portable safety auto-injector
BR0314111A (en) 2002-09-12 2005-07-26 Childrens Hosp Medical Center Method and device for painless medication injection
DE60328109D1 (en) 2002-09-24 2009-08-06 Shl Group Ab INJECTION DEVICE
US7699816B2 (en) 2002-10-15 2010-04-20 Tecpharma Licensing Ag Injection device with priming stroke
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
JP2006504476A (en) 2002-11-05 2006-02-09 エム２・メディカル・アクティーゼルスカブ Disposable, wearable insulin administration device, combination of the device and program control device, and operation control method of the device
JP2006507061A (en) 2002-11-25 2006-03-02 テクファーマ・ライセンシング・アクチェンゲゼルシャフト Automatic injection device with resettable release safety device
EP1572268A1 (en) 2002-11-25 2005-09-14 Tecpharma Licensing AG Device for automatically injecting an active agent
WO2004047892A1 (en) 2002-11-25 2004-06-10 Tecpharma Licensing Ag Injection apparatus comprising a needle-protecting device
GB2396816A (en) 2002-12-17 2004-07-07 Pa Consulting Services Injection device
GB0229345D0 (en) 2002-12-17 2003-01-22 Safe T Ltd Hollow needle applicators
US6767336B1 (en) 2003-01-09 2004-07-27 Sheldon Kaplan Automatic injector
AU2003303809A1 (en) 2003-01-24 2004-08-23 Alza Corporation Collapsible syringe cartridge
USD494270S1 (en) 2003-02-04 2004-08-10 Sherwood Services Ag Electrosurgical pencil with multiple scallops
US6932794B2 (en) 2003-04-03 2005-08-23 Becton, Dickinson And Company Medication delivery pen
US7534107B2 (en) 2003-04-14 2009-05-19 The General Hospital Corporation Inoculation training kit
US6805686B1 (en) * 2003-05-06 2004-10-19 Abbott Laboratories Autoinjector with extendable needle protector shroud
US6926697B2 (en) 2003-05-13 2005-08-09 Robert Malenchek Adaptor for converting a non-safety syringe into a safety syringe
GB0315600D0 (en) 2003-07-04 2003-08-13 Owen Mumford Ltd Improvements relating to automatic injection devices
US7500963B2 (en) 2003-07-22 2009-03-10 Safety Syringes, Inc. Systems and methods for automatic medical injection with safeguard
US20050027255A1 (en) 2003-07-31 2005-02-03 Sid Technologies, Llc Automatic injector
EP1502613A1 (en) 2003-08-01 2005-02-02 Novo Nordisk A/S Needle device with retraction means
DE20312677U1 (en) * 2003-08-16 2004-12-23 Schwarzbich, Jörg Syringe with a reuse lock
DE10339794A1 (en) 2003-08-28 2005-04-07 Tecpharma Licensing Ag Administering device with a protective cap removal device and a needle protection sleeve blocking device
DE10340586A1 (en) 2003-09-03 2005-04-07 Tecpharma Licensing Ag Mixing device for multi-chamber ampoule
FR2860162B1 (en) 2003-09-26 2006-06-02 Becton Dickinson France DEVICE FOR PROTECTING AN INJECTION APPARATUS
GB0406458D0 (en) 2003-10-09 2004-04-28 Liversidge Barry P Safety medical needle assemblies
US20050085776A1 (en) 2003-10-16 2005-04-21 Edgar Hommann Injection device for administering a fluid product
USD518175S1 (en) 2003-10-31 2006-03-28 Wilson-Cook Medical Inc. Handle for medical devices, and medical device assemblies using a handle
US7497847B2 (en) 2003-11-03 2009-03-03 Becton, Dickinson And Company Safety shield system for a syringe
US9554984B2 (en) 2003-11-03 2017-01-31 Jaleva Pharmaceuticals, Llc Oral care compositions for topical application
US20050096597A1 (en) 2003-11-03 2005-05-05 Becton, Dickinson And Company Safety shield system for a syringe
US7635348B2 (en) 2003-11-04 2009-12-22 Meridian Medical Technologies, Inc. Container for medicament automatic injector and automatic injector adapted therefor
US20050101919A1 (en) 2003-11-07 2005-05-12 Lennart Brunnberg Device for an injector
US20050115508A1 (en) 2003-12-01 2005-06-02 Little Cynthia L. Healthy pet appropriate food and drink table
GB2410188B (en) 2004-01-23 2006-01-25 Medical House Plc Injection device
GB0403335D0 (en) 2004-02-14 2004-03-17 Liversidge Barry P Medical injector handling device
ITTO20040169A1 (en) 2004-03-15 2004-06-15 Teksid Aluminum S R L SEALING SYSTEM FOR HIGH PRESSURE AND HIGH TEMPERATURE CONTAINERS
JP4874233B2 (en) 2004-03-30 2012-02-15 イーライ リリー アンド カンパニー Drug delivery device with spring-driven fixation feature enabled by final dose administration
US20050222539A1 (en) 2004-03-30 2005-10-06 Pediamed Pharmaceuticals, Inc. Automatic injection device
AU2005231716B2 (en) 2004-03-31 2010-08-05 Izi Medical Products, Llc Apparatus for an improved high pressure medicinal dispenser
TWI439284B (en) 2004-04-09 2014-06-01 Abbvie Biotechnology Ltd Multiple-variable dose regimen for treating tnfα-related disorders
EP2060292B1 (en) 2004-04-29 2016-07-13 AbbVie Inc. Autoinjector with extendable needle protector shroud
US6976676B2 (en) * 2004-05-10 2005-12-20 Adams Troy E Game apparatus
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
GB2414404B (en) 2004-05-28 2009-06-03 Cilag Ag Int Injection device
GB2414406B (en) 2004-05-28 2009-03-18 Cilag Ag Int Injection device
GB2414402B (en) 2004-05-28 2009-04-22 Cilag Ag Int Injection device
GB2414405B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414403B (en) 2004-05-28 2009-01-07 Cilag Ag Int Injection device
GB2414400B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
US20050273054A1 (en) 2004-06-03 2005-12-08 Florida Atlantic University Epinephrine auto-injector
US7294119B2 (en) * 2004-06-10 2007-11-13 Safety Syringes, Inc. Passive delivery system diluents mixing and delivery
US20050283162A1 (en) * 2004-06-22 2005-12-22 Stratas Byron A Intraocular lens inserter
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
EP1791583A4 (en) 2004-07-16 2016-08-17 Unitract Syringe Pty Ltd Syringe needle sheath
US20060100588A1 (en) 2004-07-23 2006-05-11 Lennart Brunnberg Needle handling device
US7449012B2 (en) 2004-08-06 2008-11-11 Meridian Medical Technologies, Inc. Automatic injector
US20060074519A1 (en) 2004-08-27 2006-04-06 Barker Kenneth N Medication accuracy comparison system
US20060047250A1 (en) 2004-08-30 2006-03-02 Hickingbotham Dyson W Fluid delivery device
DE102004042581B4 (en) 2004-09-02 2022-09-15 Ypsomed Ag Auto-Pen for dual-chamber ampoule
US20060069350A1 (en) 2004-09-30 2006-03-30 Buenger David R Medical syringe injector pen
US20060069354A1 (en) 2004-09-30 2006-03-30 Buenger David R Syringe activation device
WO2006041970A2 (en) 2004-10-08 2006-04-20 Abbott Biotechnology Ltd. Treatment of respiratory syncytial virus (rsv) infection
US20060089540A1 (en) 2004-10-27 2006-04-27 Alan Meissner Device for diabetes management
US20060178865A1 (en) 2004-10-29 2006-08-10 Edwards D Craig Multilingual user interface for a medical device
GB2453069B (en) 2004-11-22 2009-12-09 Intelliject Llc Devices,systems and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
CN101087626B (en) 2004-11-24 2012-11-14 贝克顿·迪金森公司 Automatic reconstitution injector device
US20060129122A1 (en) 2004-12-06 2006-06-15 Wyrick Ronald E Method and apparatus for delivering epinephrine
US7905352B2 (en) 2004-12-06 2011-03-15 Washington Biotech Corporation Kits containing medicine injection devices and containers
CN101111281B (en) 2005-02-01 2013-02-06 因特利杰克特有限公司 Devices, systems, and methods for medicament delivery
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8226610B2 (en) 2005-02-01 2012-07-24 Intelliject, Inc. Medical injector with compliance tracking and monitoring
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8062252B2 (en) 2005-02-18 2011-11-22 Becton, Dickinson And Company Safety shield system for a syringe
US20090240210A1 (en) 2005-03-14 2009-09-24 Global Medisafe Holdings Limited Auto retractable syringe
USD545439S1 (en) 2005-04-15 2007-06-26 Becton, Dickinson And Company Blood glucose meter
FR2884723B1 (en) 2005-04-20 2008-03-14 Becton Dickinson France Soc Pa DEVICE FOR PROTECTING AN INJECTION DEVICE
CN100544784C (en) * 2005-04-26 2009-09-30 刘文杰 The barrel type push bar of needle retraction type syringe and needle retractable controllable type syringe
US7694828B2 (en) 2005-04-27 2010-04-13 Biomet Manufacturing Corp. Method and apparatus for producing autologous clotting components
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
KR101465456B1 (en) 2005-05-16 2014-11-27 애브비 바이오테크놀로지 리미티드 Use of TNF inhibitor for treatment of erosive polyarthritis
US20070041905A1 (en) 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
CN101282752A (en) 2005-10-11 2008-10-08 伊莱利利公司 Apparatus for injecting a pharmaceutical
US7919264B2 (en) 2005-11-01 2011-04-05 Abbott Biotechnology Ltd. Methods and compositions for determining the efficacy of a treatment for ankylosing spondylitis using biomarkers
US7682155B2 (en) 2005-11-03 2010-03-23 Meridian Medical Technologies, Inc. Training device for an automatic injector
US20070161960A1 (en) 2006-01-12 2007-07-12 Fu-Yuan Li Lancet device
AU2007227200B2 (en) 2006-03-21 2013-01-24 Covidien Lp Passive latch ring safety shield for injection devices
JP5277157B2 (en) 2006-03-29 2013-08-28 インテリジェクト，インコーポレイテッド Drug delivery device
KR20140071452A (en) 2006-04-05 2014-06-11 애브비 바이오테크놀로지 리미티드 Antibody purification
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US20090317399A1 (en) 2006-04-10 2009-12-24 Pollack Paul F Uses and compositions for treatment of CROHN'S disease
US20080118496A1 (en) 2006-04-10 2008-05-22 Medich John R Uses and compositions for treatment of juvenile rheumatoid arthritis
WO2007120656A2 (en) 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of rheumatoid arthritis
EP2666472A3 (en) 2006-04-10 2014-04-02 Abbott Biotechnology Ltd Uses and compositions for treatment of psoriatic arthritis
EP2012586A4 (en) 2006-04-10 2010-08-18 Abbott Biotech Ltd Uses and compositions for treatment of ankylosing spondylitis
US20080131374A1 (en) 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
US20100021451A1 (en) 2006-06-08 2010-01-28 Wong Robert L Uses and compositions for treatment of ankylosing spondylitis
US20080311043A1 (en) 2006-06-08 2008-12-18 Hoffman Rebecca S Uses and compositions for treatment of psoriatic arthritis
CA2651992A1 (en) 2006-06-30 2008-01-10 Abbott Biotechnology Ltd. Automatic injection device
CA2692430A1 (en) 2006-07-07 2008-01-10 Bioassets Development Corporation Methods for preventing, postponing or improving the outcome of spinal device and fusion procedures
DE102006038101A1 (en) 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injection device with jaw safety
USD622374S1 (en) 2006-09-06 2010-08-24 Abbott Biotechnology Ltd. Automatic injection device
USD629509S1 (en) 2006-09-06 2010-12-21 Abbott Biotechnology Ltd. Automatic injection device
RU2518289C2 (en) 2006-09-13 2014-06-10 Эббви Инк, Method for preparing fed-batch antibody or its fragment (versions)
CN100563740C (en) 2006-09-28 2009-12-02 明辰股份有限公司 Safe medicament injection apparatus for medical and be used for the push bar assembly of medical medicine injection
EP2684895A1 (en) 2006-10-27 2014-01-15 AbbVie Biotechnology Ltd Crystalline anti-hTNFalpha antibodies
DK2099434T3 (en) 2006-11-21 2019-08-12 Kaleo Inc DEVICES AND SYSTEMS FOR MEDICINAL ADMINISTRATION
JP5014835B2 (en) 2007-02-28 2012-08-29 株式会社山越 Rainwater infiltration dredging and rainwater infiltration hatching method for existing rainwater dredging
US9044378B2 (en) 2007-05-31 2015-06-02 Safety Syringes, Inc. Anti-needle stick safety device or system for use with drugs requiring reconstitution
EP2679995A1 (en) 2007-05-31 2014-01-01 AbbVie Inc. Biomarkers predictive of the responsiveness to TNF-alfa inhibitors in autoimmune disorders
WO2008150490A2 (en) 2007-06-01 2008-12-11 Abbott Biotechnology Ltd. Uses and compositions for treatment of psoriasis and crohn's disease
US8999337B2 (en) 2007-06-11 2015-04-07 Abbvie Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis by inhibition of TNFα
CN101848733A (en) 2007-07-13 2010-09-29 艾博特生物技术有限公司 The method and composition that is used for pulmonary administration TNF alpha inhibitor
WO2009020654A1 (en) 2007-08-08 2009-02-12 Abbott Laboratories Compositions and methods for crystallizing antibodies
ES2742504T3 (en) 2007-09-25 2020-02-14 Becton Dickinson France Autoinjector with shield elimination element comprising anti-tamper means
US20090093793A1 (en) 2007-10-02 2009-04-09 Yossi Gross External drug pump
USD619702S1 (en) 2007-11-15 2010-07-13 Tecpharma Licensing Ag Medicine injector
KR20190045414A (en) 2007-11-30 2019-05-02 애브비 바이오테크놀로지 리미티드 Protein formulations and methods of making same
US20090157012A1 (en) 2007-12-13 2009-06-18 University Of Victoria Innovation And Development Corporation Syringe with extendable and retractable needle
EP2238446A4 (en) 2008-01-03 2011-07-20 Abbott Biotech Ltd Predicting long-term efficacy of a compound in the treatment of psoriasis
EP2240222B1 (en) 2008-01-11 2018-04-04 UCB Biopharma SPRL Systems for administering medication for rheumatoid arthritis patients
NZ621174A (en) 2008-01-15 2015-09-25 Abbvie Deutschland Powdered protein compositions and methods of making same
RU2502800C2 (en) 2008-01-15 2013-12-27 Эббви Инк. Improved expression vectors of mammals and their use
WO2009118662A2 (en) 2008-03-24 2009-10-01 Abbott Biotechnology Ltd. Methods and compositions for treating bone loss
EP2285360B1 (en) 2008-05-12 2016-04-13 Kaleo, Inc. Medicament delivery device having an electronic circuit system
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
KR20110037979A (en) 2008-05-30 2011-04-13 알러간, 인코포레이티드 Injection device for soft-tissue augmentation fillers, bioactive agents and other biocompatible materials in liquid or gel form
US8069097B2 (en) 2008-06-05 2011-11-29 Harris Corporation Media inventory service
JP2011524792A (en) 2008-06-20 2011-09-08 ウエスト・ファーマシューティカル・サービシーズ・インコーポレイテッド Automatic injection mechanism with front support wall
JP5161712B2 (en) 2008-09-03 2013-03-13 キヤノン株式会社 Imaging apparatus and imaging method
WO2010029054A1 (en) 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Delivery device for use with a therapeutic drug
USD641077S1 (en) 2008-09-15 2011-07-05 Sanofi-Aventis Deutschland Gmbh Medical injector
EP2180459A1 (en) 2008-10-24 2010-04-28 Sanofi-Aventis Deutschland GmbH Device for simulating the operation of a medication delivery device
GB2465389A (en) 2008-11-17 2010-05-19 Owen Mumford Ltd Syringe needle cover remover
USD621932S1 (en) 2009-03-23 2010-08-17 Karl Storz Gmbh & Co. Kg Videolaparoscope
USD629098S1 (en) 2009-03-23 2010-12-14 Karl Storz Gmbh & Co. Kg Videolaparoscope
CA2760237C (en) 2009-04-29 2017-11-14 Abbott Biotechnology Ltd. Automatic injection device and plunger for same
SG175188A1 (en) 2009-05-04 2011-11-28 Abbott Biotech Ltd Stable high protein concentration formulations of human anti-tnf-alpha-antibodies
ES2944912T3 (en) 2009-05-26 2023-06-27 Shl Medical Ag needle cover assembly
CA2769030C (en) 2009-07-30 2016-05-10 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
AU2010276511B2 (en) 2009-07-31 2013-09-19 Kindeva Drug Delivery L.P. Hollow microneedle arrays
USD633199S1 (en) 2009-10-05 2011-02-22 Pyng Medical Corp. Insertion tool for bone portals
KR101780210B1 (en) 2009-12-15 2017-09-21 애브비 바이오테크놀로지 리미티드 Improved firing button for automatic injection device
MX2012008985A (en) 2010-02-02 2012-09-07 Abbott Biotech Ltd Methods and compositions for predicting responsiveness to treatment with tnf-î± inhibitor.
EP2361648A1 (en) 2010-02-18 2011-08-31 Sanofi-Aventis Deutschland GmbH Remover for a protective needle shield
MX339532B (en) 2010-04-21 2016-05-30 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents.
USD645139S1 (en) 2010-05-11 2011-09-13 Discus Dental, Llc Dental composite syringe
ES2685607T3 (en) 2010-06-03 2018-10-10 Abbvie Biotechnology Ltd Uses and compositions for the treatment of Hidradenitis Suppurativa (HS)
USD638935S1 (en) 2010-06-25 2011-05-31 Abbott Cardiovascular Systems Inc. Medical device handle
USD650070S1 (en) 2010-09-16 2011-12-06 Panasonic Corporation Injector
USD647613S1 (en) 2010-12-30 2011-10-25 Kimberly-Clark, Inc. Ergonomic handle for medical device
US8708968B2 (en) 2011-01-24 2014-04-29 Abbvie Biotechnology Ltd. Removal of needle shields from syringes and automatic injection devices
ES2710905T3 (en) 2011-01-24 2019-04-29 E3D Agricultural Coop Association Ltd Injector
EP2749305B1 (en) 2011-01-24 2017-11-01 AbbVie Biotechnology Ltd Automatic injection devices having overmolded gripping surfaces
USD677380S1 (en) 2011-01-24 2013-03-05 Abbvie Biotechnology Ltd. Automatic injection device
CN103608053B (en) 2011-03-18 2016-06-22 艾伯维公司 For assembling the system of automated injection device and sub-component thereof, apparatus and method
ES2669198T5 (en) 2011-03-29 2021-07-20 Abbvie Inc Enhanced shell deployment on automatic injection devices
USD653329S1 (en) 2011-05-11 2012-01-31 Femasys Inc. Device for relieving fluid pressure
ES2587993T3 (en) 2012-03-02 2016-10-28 Abbvie Inc. Automatic injection learning device

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