CA2569607A1 - Expandable medical device for delivery of beneficial agent - Google Patents

Expandable medical device for delivery of beneficial agent Download PDF

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Publication number
CA2569607A1
CA2569607A1 CA002569607A CA2569607A CA2569607A1 CA 2569607 A1 CA2569607 A1 CA 2569607A1 CA 002569607 A CA002569607 A CA 002569607A CA 2569607 A CA2569607 A CA 2569607A CA 2569607 A1 CA2569607 A1 CA 2569607A1
Authority
CA
Canada
Prior art keywords
medical device
expandable medical
ductile hinges
interconnected
rigid sections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002569607A
Other languages
French (fr)
Other versions
CA2569607C (en
Inventor
John F. Shanley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovational Holdings LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2569607A1 publication Critical patent/CA2569607A1/en
Application granted granted Critical
Publication of CA2569607C publication Critical patent/CA2569607C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541—Adjacent bands are arranged out of phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir

Abstract

An expandable stent comprises a plurality of substantially rigid sections (418); a plurality of ductile hinges (420) interconnecting the plurality of substantially rigid sections (418) to form the cylindrical stent (400) which is expandable from a first diameter to a second diameter by deformation of the plurality of ductile hinges (420) without substantial deformation of the substantially rigid sections (418); and a plurality of openings (424) containing a beneficial agent, the openings (424) positioned in the substantially rigid sections (418), wherein the plurality of substantially rigid sections (418) and the plurality of ductile hinges (420) are interconnected in a plurality of alternating interconnected U-shapes, wherein the plurality of alternating interconnected U shapes form a helically wound band.

Claims (31)

1. An expandable medical device comprising:
at least one cylindrical tube;
a plurality of substantially rigid sections interconnected to form the at least one cylindrical tube;
a plurality of ductile hinges formed between the substantially rigid sections, the ductile hinges allowing the cylindrical tube to be expanded or compressed from a first diameter to a second diameter by deformation of the ductile hinges without substantial deformation of the substantially rigid sections;
a plurality of beneficial agent containing openings in the plurality of substantially rigid sections;
wherein the plurality of substantially rigid sections and the plurality of ductile hinges are interconnected in a plurality of alternating interconnected U-shapes to form the at least one cylindrical tube; and wherein the interconnected U-shapes each include at least four substantially rigid sections and at least three ductile hinges.
2. The expandable medical device according to Claim 1, wherein said plurality of beneficial agent containing openings are non-deforming openings.
3. The expandable medical device according to Claim 1, wherein said the plurality of beneficial agent containing openings extend through a thickness of the at least one cylindrical tube, so as to thereby define a through-opening.
4. The expandable medical device according to Claim 1, wherein the plurality of beneficial agent containing openings have a depth less than a thickness of the at least one cylindrical tube, so as to thereby define a recess.
5. The expandable medical device according to Claim 1, wherein a single beneficial agent containing opening is located in each of the plurality of rigid sections.
6. The expandable medical device according to Claim 1, wherein a plurality of beneficial agent containing openings are located in each of the plurality of rigid sections.
7. The expandable medical device according to Claim 1, wherein the interconnected U-shapes each include at least three substantially rigid sections and at least two ductile hinges.
8. The expandable medical device according to Claim 1, wherein the ductile hinges have different widths depending on their location in the interconnected U-shapes.
9. The expandable medical device according to Claim 8, wherein ductile hinges closer to the bases of the interconnected U-shapes have a larger width than ductile hinges farther from the bases of the interconnected U-shapes.
10. The expandable medical device according to Claim 1, wherein a width of the ductile hinges varies depending on a position of the ductile hinge on the at least one cylindrical tube in an axial direction.
11. The expandable medical device according to Claim 10, wherein a width of the ductile hinges closest to the ends of the at least one cylindrical tube is greater than a width of the ductile hinges closest to the center of the at least one cylindrical tube.
12. The expandable medical device according to Claim 1, wherein the ductile hinges are tapered such that a width of each ductile hinges closest to the ends of the at least one cylindrical tube is greater than a width of the ductile hinges closest to the center of the at least one cylindrical tube.
13. The expandable medical device according to Claim 1, wherein said beneficial agent includes antiproliferatives.
14. The expandable medical device according to Claim 1, wherein said at least one cylindrical tube includes two cylindrical tubes interconnected by a bridging element.
15. The expandable medical device according to Claim 14, wherein the bridging element includes at least one flexible segment and at least one substantially rigid section having a beneficial agent containing opening.
16. The expandable medical device according to Claim 1, wherein the ductile hinges are designed to deform plastically upon radial expansion or compression of the expandable medical device while the plurality of substantially rigid sections experience substantially no plastic deformation upon radial expansion or compression.
17. The expandable medical device according to Claim 8, wherein the interconnected U-shapes are asymmetrical.
18. An expandable stent comprising:
a plurality of substantially rigid sections;
a plurality of ductile hinges interconnecting the plurality of substantially rigid sections to form a cylindrical stent which is expandable from a first diameter to a second diameter by deformation of the plurality of ductile hinges without substantial deformation of the substantially rigid sections, wherein the ductile hinges have different widths depending on their location in the stent; and a plurality of openings containing a beneficial agent, the openings positioned in the substantially rigid sections.
19. The expandable medical device according to Claim 20, wherein said plurality of openings are non-deforming openings.
20. The expandable medical device according to Claim 18, wherein said the plurality of openings extend through a thickness of the at least one cylindrical tube, so as to thereby define a through-opening.
21. The expandable medical device according to Claim 18, wherein the plurality of openings have a depth less than a thickness of the at least one cylindrical tube, so as to thereby define a recess.
22. The expandable medical device according to Claim 18, wherein a single beneficial agent containing opening is located in each of the plurality of rigid sections.
23. The expandable medical device according to Claim 18, wherein a plurality of beneficial agent containing openings are located in each of the plurality of rigid sections.
24. The expandable medical device according to Claim 18, wherein the plurality of substantially rigid sections and the plurality of ductile hinges are interconnected in plurality of alternating interconnected U-shapes.
25. The expandable medical device according to Claim 24, wherein the plurality of alternating interconnected U-shapes form a cylindrical tube.
26. The expandable medical device according to Claim 24, wherein the plurality of alternating interconnected U-shapes form a helically wound band.
27. The expandable medical device according to Claim 24, wherein the interconnected U-shapes each include at least four substantially rigid sections and at least three ductile hinges.
28. The expandable medical device according to Claim 24, wherein ductile hinges closer to the bases of the interconnected U-shapes have a larger width than ductile hinges farther from the bases of the interconnected U-shapes.
29. The expandable medical device according to Claim 18, wherein a width of the ductile hinges varies depending on a position of the ductile hinge on the at least one cylindrical tube in an axial direction.
30. The expandable medical device according to Claim 29, wherein a width of the ductile hinges closest to the ends of the at least one cylindrical tube is greater than a width of the ductile hinges closest to the center of the at least one cylindrical tube.
31. The expandable medical device according to Claim 18, wherein the ductile hinges are designed to deform plastically upon radial expansion or compression of the expandable medical device while the plurality of substantially rigid sections experience substantially no plastic deformation upon radial expansion or compression.
CA2569607A 2004-06-07 2005-06-03 Expandable medical device for delivery of beneficial agent Expired - Fee Related CA2569607C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/862,963 2004-06-07
US10/862,963 US7179289B2 (en) 1998-03-30 2004-06-07 Expandable medical device for delivery of beneficial agent
PCT/US2005/019663 WO2005120397A1 (en) 2004-06-07 2005-06-03 Expandable medical device for delivery of beneficial agent

Publications (2)

Publication Number Publication Date
CA2569607A1 true CA2569607A1 (en) 2005-12-22
CA2569607C CA2569607C (en) 2012-05-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2569607A Expired - Fee Related CA2569607C (en) 2004-06-07 2005-06-03 Expandable medical device for delivery of beneficial agent

Country Status (8)

Country Link
US (1) US7179289B2 (en)
EP (2) EP1768609B1 (en)
JP (1) JP5001149B2 (en)
AT (1) ATE501691T1 (en)
AU (1) AU2005251777B2 (en)
CA (1) CA2569607C (en)
DE (1) DE602005026945D1 (en)
WO (1) WO2005120397A1 (en)

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US20040225350A1 (en) 2004-11-11
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US7179289B2 (en) 2007-02-20

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