CA2556486A1 - Artificial intervertebral disc having a universal joint - Google Patents
Artificial intervertebral disc having a universal joint Download PDFInfo
- Publication number
- CA2556486A1 CA2556486A1 CA002556486A CA2556486A CA2556486A1 CA 2556486 A1 CA2556486 A1 CA 2556486A1 CA 002556486 A CA002556486 A CA 002556486A CA 2556486 A CA2556486 A CA 2556486A CA 2556486 A1 CA2556486 A1 CA 2556486A1
- Authority
- CA
- Canada
- Prior art keywords
- baseplate
- strap
- articulating element
- artificial intervertebral
- intervertebral implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2/4425—Intervertebral or spinal discs, e.g. resilient made of articulated components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30744—End caps, e.g. for closing an endoprosthetic cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30242—Three-dimensional shapes spherical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30331—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
- A61F2002/30362—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit with possibility of relative movement between the protrusion and the recess
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30621—Features concerning the anatomical functioning or articulation of the prosthetic joint
- A61F2002/30649—Ball-and-socket joints
- A61F2002/30663—Ball-and-socket joints multiaxial, e.g. biaxial; multipolar, e.g. bipolar or having an intermediate shell articulating between the ball and the socket
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/30682—Means for preventing migration of particles released by the joint, e.g. wear debris or cement particles
- A61F2002/30685—Means for reducing or preventing the generation of wear particulates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2/4425—Intervertebral or spinal discs, e.g. resilient made of articulated components
- A61F2002/443—Intervertebral or spinal discs, e.g. resilient made of articulated components having two transversal endplates and at least one intermediate component
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0033—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0071—Three-dimensional shapes spherical
Abstract
An artificial intervertebral implant (1) including a first baseplate (10) having a top surface (20), a bottom surface (22), an aperture (30) extending therethrough and a strap (34) attached to the bottom surface (22) of the first baseplate (10) and underlying the aperture (30). The implant (1) further includes a second baseplate (12) juxtaposed with the first baseplate (10). The second baseplate (12) includes a top surface (50) with a cavity (54) exposed therein. An articulating element (14) is attached to a pair of opposing sidewalls (58, 59) of the cavity (54) for retaining the strap (34) within the cavity (54).
Claims (17)
1. An artificial intervertebral disc comprising:
a first baseplate having a top surface, a bottom surface, an aperture extending from said top surface to said bottom surface and a strap attached to said bottom surface of said first baseplate and underlying said aperture;
a second baseplate juxtaposed with said first baseplate, said second baseplate having a top surface, a bottom surface and a cavity exposed at said top surface of said second baseplate;
an articulating element disposed within said aperture and overlaying said strap, said articulating element being attached to a pair of opposing sidewalls of said cavity retaining said strap within said cavity for permitting said first and second baseplates to angulate and rotate relative to one another with said strap translating over said articulating element.
a first baseplate having a top surface, a bottom surface, an aperture extending from said top surface to said bottom surface and a strap attached to said bottom surface of said first baseplate and underlying said aperture;
a second baseplate juxtaposed with said first baseplate, said second baseplate having a top surface, a bottom surface and a cavity exposed at said top surface of said second baseplate;
an articulating element disposed within said aperture and overlaying said strap, said articulating element being attached to a pair of opposing sidewalls of said cavity retaining said strap within said cavity for permitting said first and second baseplates to angulate and rotate relative to one another with said strap translating over said articulating element.
2. The artificial intervertebral implant according to claim 1, wherein said pair of opposing sidewalls include a first sidewall having a first indent and a second sidewall having a second indent, said articulating element being attached to said first sidewall and said second sidewall at said first indent and said second indent, respectively.
3. The artificial intervertebral implant according to claim 2, wherein said pair of opposing sidewalls have a plurality of ends that are angled, such that during rotational movement of said first baseplate or said second baseplate said strap has an increased range of motion within said cavity.
4. The artificial intervertebral implant according to claim 1, wherein said pair of opposing sidewalls include a plurality of ends that are angled, such that during rotational movement of said first baseplate or said second baseplate said strap has an increased range of motion within said cavity.
5. The artificial intervertebral implant according to claim 1, further comprising a cover having a bottom surface, said cover being at least partially disposed within said aperture such that said cover overlies said articulating element thereby capturing said articulating element between said cover and said strap.
6. The artificial intervertebral implant according to claim 5, wherein said cover further includes a cap and a post, wherein said top surface of said first baseplate includes a recess circumferentially extending about said aperture, wherein said post of said cover is compression fit within said aperture and said cap of said cover is compression fit within said recess.
7. The artificial intervertebral implant according to claim 5, wherein said distance between said top surface of said strap and said bottom surface of said cover is greater than a length of said articulating element, such that said first baseplate and said second baseplate may move in an axial direction relative to one another.
8. The artificial intervertebral implant according to claim 7, wherein said bottom surface of said cover and said top surface of said strap have a radius of curvature substantially equal to a radius of curvature of said articulating element, such that said strap and said cover translate about said articulating element as said first baseplate moves relative to said second baseplate in both an angulational direction and a rotational direction.
9. The artificial intervertebral disc according to claim 1, wherein said articulating element is a ball.
10. An artificial intervertebral implant comprising:
a first baseplate having a top surface, a bottom surface, an aperture extending therebetween and a strap underlying said aperture;
an articulating element disposed within said aperture and overlying said strap, said articulating element being stationary relative to a first element, said first element being adjacent a side of said articulating element remote from first baseplate, said strap being able to freely rotate about said articulating element with a desired angle range.
a first baseplate having a top surface, a bottom surface, an aperture extending therebetween and a strap underlying said aperture;
an articulating element disposed within said aperture and overlying said strap, said articulating element being stationary relative to a first element, said first element being adjacent a side of said articulating element remote from first baseplate, said strap being able to freely rotate about said articulating element with a desired angle range.
11. The artificial intervertebral implant according to claim 10, wherein said first element is a second baseplate.
12. The artificial intervertebral implant according to claim 10, wherein said articulating element is a ball.
13. The artificial intervertebral implant according to claim 10, wherein a first distance between said strap and said top surface of said first baseplate is larger than a second distance between a pair of remote ends on said articulating element such that said strap and said first baseplate may move in an axial direction relative to said articulating element.
14. An artificial intervertebral implant comprising:
a first baseplate having a top surface, a bottom surface and a strap have a first end and a second end, said first end and said end of said strap being remote from one another and attached to said bottom surface such that said strap underlies said first baseplate, said strap at least partially defining an aperture therein;
a second baseplate juxtaposed with said first baseplate, said second baseplate having a top surface and a bottom surface;
an articulating element disposed within said aperture at least partially defined by said strap and attached to said second baseplate; and wherein said strap is captured between said articulating element and said second baseplate and wherein said strap is free to rotate and angulate about said articulating element within a desired range of angles.
a first baseplate having a top surface, a bottom surface and a strap have a first end and a second end, said first end and said end of said strap being remote from one another and attached to said bottom surface such that said strap underlies said first baseplate, said strap at least partially defining an aperture therein;
a second baseplate juxtaposed with said first baseplate, said second baseplate having a top surface and a bottom surface;
an articulating element disposed within said aperture at least partially defined by said strap and attached to said second baseplate; and wherein said strap is captured between said articulating element and said second baseplate and wherein said strap is free to rotate and angulate about said articulating element within a desired range of angles.
15. The artificial intervertebral implant according to claim 14, wherein said strap is continuous.
16. The artificial intervertebral implant according to claim 14, wherein said aperture extends from said strap to said top surface of said first baseplate.
17. The artificial intervertebral implant according to claim 14, wherein said top surface of said second baseplate includes a cavity having a pair of opposing sidewalls, said articulating element attached to said second baseplate at said pair of opposing sidewall, said strap being retained at least partially underlying said articulating element and disposed within said cavity such that said strap is free to translate about said articulating element within a desired range of angles.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54623004P | 2004-02-20 | 2004-02-20 | |
US60/546,230 | 2004-02-20 | ||
PCT/US2005/005342 WO2005081884A2 (en) | 2004-02-20 | 2005-02-18 | Artificial intervertebral disc having a universal joint |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2556486A1 true CA2556486A1 (en) | 2005-09-09 |
CA2556486C CA2556486C (en) | 2010-03-23 |
Family
ID=34910758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2556486A Expired - Fee Related CA2556486C (en) | 2004-02-20 | 2005-02-18 | Artificial intervertebral disc having a universal joint |
Country Status (6)
Country | Link |
---|---|
US (1) | US7468076B2 (en) |
EP (1) | EP1729692A4 (en) |
JP (2) | JP4510836B2 (en) |
AU (1) | AU2005216112B2 (en) |
CA (1) | CA2556486C (en) |
WO (1) | WO2005081884A2 (en) |
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US8353933B2 (en) | 2007-04-17 | 2013-01-15 | Gmedelaware 2 Llc | Facet joint replacement |
US8562649B2 (en) | 2004-02-17 | 2013-10-22 | Gmedelaware 2 Llc | System and method for multiple level facet joint arthroplasty and fusion |
US7195644B2 (en) * | 2004-03-02 | 2007-03-27 | Joint Synergy, Llc | Ball and dual socket joint |
US7507242B2 (en) | 2004-06-02 | 2009-03-24 | Facet Solutions | Surgical measurement and resection framework |
WO2006042484A1 (en) * | 2004-10-18 | 2006-04-27 | Buettner-Janz Karin | Bent sliding core as part of an intervertebral disk endoprosthesis |
WO2006042485A1 (en) * | 2004-10-18 | 2006-04-27 | Buettner-Janz Karin | Intervertebral disk endoprosthesis for lumbar and cervical spine, which corresponds to the physiology of movement |
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CA2628236A1 (en) * | 2005-11-04 | 2007-05-10 | Peter Mccombe | A method of reducing loading failure for a prosthetic component |
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US8029574B2 (en) | 2006-11-07 | 2011-10-04 | Biomedflex Llc | Prosthetic knee joint |
US9005307B2 (en) | 2006-11-07 | 2015-04-14 | Biomedflex, Llc | Prosthetic ball-and-socket joint |
US8308812B2 (en) | 2006-11-07 | 2012-11-13 | Biomedflex, Llc | Prosthetic joint assembly and joint member therefor |
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US8715352B2 (en) | 2006-12-14 | 2014-05-06 | Depuy Spine, Inc. | Buckling disc replacement |
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US7972380B2 (en) * | 2007-09-17 | 2011-07-05 | Linares Medical Devices, Llc | Artificial joint support between first and second bones |
US9011538B2 (en) | 2009-01-21 | 2015-04-21 | Warsaw Orthopedic, Inc. | Methods of spinal nucleus replacemennt |
US9011539B2 (en) | 2009-01-21 | 2015-04-21 | Warsaw Orthopedic, Inc. | Spinal nucleus replacement implant |
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CN108969157B (en) * | 2018-07-27 | 2021-07-09 | 深圳清华大学研究院 | Highly bionic intervertebral motion retaining device |
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-
2005
- 2005-02-18 CA CA2556486A patent/CA2556486C/en not_active Expired - Fee Related
- 2005-02-18 US US11/062,008 patent/US7468076B2/en not_active Expired - Fee Related
- 2005-02-18 EP EP05713834A patent/EP1729692A4/en not_active Withdrawn
- 2005-02-18 JP JP2006554255A patent/JP4510836B2/en not_active Expired - Fee Related
- 2005-02-18 AU AU2005216112A patent/AU2005216112B2/en not_active Ceased
- 2005-02-18 WO PCT/US2005/005342 patent/WO2005081884A2/en not_active Application Discontinuation
-
2009
- 2009-07-08 JP JP2009162085A patent/JP5014383B2/en not_active Expired - Fee Related
Also Published As
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EP1729692A4 (en) | 2012-04-25 |
JP2009219933A (en) | 2009-10-01 |
JP4510836B2 (en) | 2010-07-28 |
AU2005216112A1 (en) | 2005-09-09 |
CA2556486C (en) | 2010-03-23 |
EP1729692A2 (en) | 2006-12-13 |
WO2005081884A3 (en) | 2006-09-14 |
US20050246022A1 (en) | 2005-11-03 |
JP2007522886A (en) | 2007-08-16 |
WO2005081884A2 (en) | 2005-09-09 |
AU2005216112B2 (en) | 2010-07-08 |
JP5014383B2 (en) | 2012-08-29 |
US7468076B2 (en) | 2008-12-23 |
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