CA2555011C - Enhancing tissue ingrowth for contraception - Google Patents
Enhancing tissue ingrowth for contraception Download PDFInfo
- Publication number
- CA2555011C CA2555011C CA2555011A CA2555011A CA2555011C CA 2555011 C CA2555011 C CA 2555011C CA 2555011 A CA2555011 A CA 2555011A CA 2555011 A CA2555011 A CA 2555011A CA 2555011 C CA2555011 C CA 2555011C
- Authority
- CA
- Canada
- Prior art keywords
- occluding
- strands
- expandable
- occluding component
- metallic material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12104—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in an air passage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12136—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12177—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/20—Vas deferens occluders; Fallopian occluders
- A61F6/22—Vas deferens occluders; Fallopian occluders implantable in tubes
- A61F6/225—Vas deferens occluders; Fallopian occluders implantable in tubes transcervical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00893—Material properties pharmaceutically effective
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
- A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
- A61B2017/12063—Details concerning the detachment of the occluding device from the introduction device electrolytically detachable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B2017/320004—Surgical cutting instruments abrasive
- A61B2017/320008—Scrapers
Abstract
This invention is directed to occluding devices and methods of using such devices for occluding a patient~s body lumen, such as a reproductive lumen for contraceptive purposes. The occluding device generally has an occluding component (11), a first metallic element (16) associated with the occluding component, a second metallic element (17) associated with the occluding component. The first and second metallic elements are configured to generate electrical activity which enhances tissue growth into and/or onto the occluding component to aid in lumen occlusion. In one embodiment the first and second metallic elements are formed of different metallic materials and generate galvanic activity. In a second embodiment electrical power is applies to the first and second metallic elements to generate electrical activity that enhances tissue growth.
Description
ENHANCING TISSUE INGROWTH FOR CONTRACEPTION
BACKGROUND OF THE INVENTION
[0001] This invention generally relates to the field of occluding devices, delivery systems for such devices and the method of using such devices and systems in the occlusion of body passageways. The invention is particularly useful for the occluding reproductive lumens such as a female patient's fallopian tubes or a male patient's vas deferens to affect contraception.
BACKGROUND OF THE INVENTION
[0001] This invention generally relates to the field of occluding devices, delivery systems for such devices and the method of using such devices and systems in the occlusion of body passageways. The invention is particularly useful for the occluding reproductive lumens such as a female patient's fallopian tubes or a male patient's vas deferens to affect contraception.
[0002] Conventional contraceptive strategies generally fall within three categories: physical barriers, drugs and surgery. While each have certain advantages, they also suffer from various drawbacks. Barriers such as condoms and diaphragms are subject to failure due to breakage, displacement and misplacement. Drug strategies, such as the pill and NorplantTM, which rely on artificially controlling hormone levels, suffer from known and unknown side-effects from prolonged use. Surgical procedures, such as tubal ligation and vasectomy, are very effective, but involve the costs and attendant risks of surgery, and are frequently not reversible.
[0003] Recently, minimally invasive treatments have be proposed which deploy stent-like devices within reproductive lumens for obstructing such lumens as a contraceptive alternative to tubal ligation. However, placing a stent alone or a stent with fibrous material or similar occluding device may not create sufficient or permanent obstruction of the reproductive lumen depending on the nature of the obstructive device. For example, the obstructive device may be too small to provide complete obstruction of the reproductive lumen, or the device may be permeable to cell movement. An occluding device placed in a reproductive lumen, for example, may not securely seal against the luminal walls, or may initially allow egg cells or sperm cells to pass through the device until tissue growth completes the occlusion of the reproductive lumen and thus allow pregnancy to occur. Additionally, the occluding device might create an obstruction sufficient to prevent the passage of an egg but allow sperm cells to pass through or by the occluding device, fertilizing an egg upstream of the obstruction and resulting in an ectopic pregnancy.
[0004] The use of an occluding contraceptive or sterilization device, particularly with mesh or fibrous material to promote tissue ingrowth, has been proposed (See for example U.S. Patent No. 6,432,116). However, with these devices there is an initial period after deployment during which the patient is at risk for cell passage through the device and which can result in pregnancy.
SUMMARY OF THE INVENTION
SUMMARY OF THE INVENTION
[0005] The present invention provides an improved devices and methods of using such devices for occluding body lumens, particularly reproductive lumens for contraceptive purposes. As used herein, tissue growth includes but is not limited to cell multiplication and/or growth resulting in tissue formation into, onto, or surrounding an occluding device. The tissue growth may be epithelialization, scar formation, or other cell growth or multiplication.
[0006] An occluding device having features of the invention generally includes an occluding component which is configured to expand within the body lumen to be occluded and first and second metallic elements which are associated with the occluding component and which are configured to generate electrical activity within a patient's body lumen to enhance the growth of tissue into or onto the occluding component of the occluding device.
[0007] In one embodiment having features of this invention, the occluding device has a occluding component and has two metallic components formed of different metallic material and electrically connected to effect galvanic activity when the occluding device contacts body fluid or other conductive fluid to stimulate cellular growth into or on the occluding component of the device. One or both of the metallic elements may be part of the occluding device or separate elements directly or indirectly attached to the occluding device.
[0008] In another embodiment having features of the invention, the occluding device has a occluding component and has two separate metallic components which are configured to be electrically connected to an electrical power source (e.g. a battery or other low voltage source) to generate the electrical activity sufficient to stimulate cell growth onto or within the occluding component of the device.
When the occluding device is deployed within a body lumen and contacts body fluid or other electrically conductive fluid (e.g. saline) therein which acts as an electrolyte, cell growth into or onto the occluding component is stimulated to enhance attachment of the device within the body lumen and occlusion of the lumen.
When the occluding device is deployed within a body lumen and contacts body fluid or other electrically conductive fluid (e.g. saline) therein which acts as an electrolyte, cell growth into or onto the occluding component is stimulated to enhance attachment of the device within the body lumen and occlusion of the lumen.
[0009] One particularly useful application for occluding devices embodying features of the invention is directed to occluding a reproductive lumen such as a fallopian tube or a vans deferens for contraceptive purposes.
In some situations, one of the metallic elements or one group of the metallic elements configured for developing electrical activity in the body lumen, may be formed of copper to provide further contraceptive action in addition to the occlusion of the lumen. Additionally, therapeutic or diagnostic agents by be employed with the occluding device for contraceptive or other uses, e.g. antibiotics, chemotherapy. For example, the occluding component can be coated with a polymer having impregnated therein an agent such as a drug, enzyme or protein, for inducing or promoting tissue growth. In yet another refinement, the surface of the occluding component may be plated with or otherwise incorporated with an elutable inflammatory material to produce an inflammatory response in the tissue of the wall defining the body lumen, which further contributes to the obstruction of the lumen.
Inflammatory materials include copper or copper alloys. Other inflammatory materials, such as radioactive materials (emitting alpha, beta or gamma particles) may be used alone or in conjunction with other inflammatory materials.
[00101 The occluding device embodying features of the invention preferably has an occluding component that at least in part has a first delivery configuration with small transverse dimensions suitable for delivery to the chosen location in a reproductive or other body lumen and a second expanded configuration larger in transverse dimensions than the first configuration to facilitate securing the occluding component of the device within the reproductive or body lumen. The occluding component of the device may be balloon expandable or self-expandable from the first configuration to the second configuration to occlude the body lumen.
[00111 The occluding device may be a tubular stent-like structure, such as described in U.S. Patent Applications Nos. 7,073,504, filed on December 18, 1996, 6,096,052, filed on July 8, 1998, 6,432,116, filed on December 21 , 1999 and 7,694,693, filed on June 27, 2003. Alternatively, the occluding device may have one or more spider-like constructions shown in co-pending U.S. Publication No.
2005/0085844, filed on December 24, 2003. The occluding component will generally be about I to about 5 mm, preferably about 2 to about 4 mm in transverse dimension in the expanded configuration and will generally be about 0.5 to about 8 cm, preferably about 1.5 to about 4 cm in length. While the description herein is focused on the use of only one occluding device, two or more occluding devices may be employed in a reproductive or other body lumen.
[0012] The occluding device having features of the invention is placed in a contracted configuration to facilitate introduction and advancement of the device within the reproductive lumen or other body lumen, usually within an inner lumen of a delivery sheath. Once in the desired position within a patient's body lumen, the delivery sheath is withdrawn while the occluding device is held in-place at the desired location. The sheath withdrawal exposes the occluding device at the chosen site and the occluding device is expanded either by inflating a balloon within the inner lumen of the occluding component or from self expansion due to the nature and condition of the metallic material of which the occluding component is made. An exposed portion of the occluding device may expand or be expanded before the entire occluding device is discharged from the delivery sheath. Self-expanding occluding components of the device may be formed of superelastic NITINOL with an austenite phase that is stable at body temperature, i.e. the material of the occluding component will not transform from the austenite phase to a martensite phase at body temperature except by the application of stress. The occluding component may also be formed of a heat expandable metallic material such as shape memory NITINOL
which has a stable martensite phase at body temperature and which returns to a remembered expanded condition when heated above the martensite-to-austenite transition temperature causing the occluding component to expand within the patient's body lumen.
[0013] The metallic elements associated with the occluding component and which generate the electrical activity within the body lumen to stimulate tissue growth may be formed at least in part of suitable conductive metallic materials such as stainless steel, NiTi alloy, platinum, tantalum, copper and gold. Other conductive materials are suitable. Moreover, the metallic elements may be part of the occluding component or be separate elements which are directly or indirectly secured to the occluding component. They may be electrically connected through one or more electrical conductors or even the occluding component itself.
100141 Fibrous strands or bundles thereof, fibrous mesh, porous polymer bodies and the like may be disposed within or on the occluding device to facilitate tissue ingrowth in addition to the electrical stimulation of tissue growth.
The fibrous bundle, fibrous mesh or porous polymeric bodies may be disposed in either balloon expandable or self-expanding occluding devices. However, mesh, fibrous or porous polymeric material within the inner lumen of balloon expandable occluding components can make balloon placement within the inner lumen difficult.
[0015] To generate the electrical activity, in general, two different metal elements which are electrically connected are immersed in an electrolyte, such as body fluids or saline or both to stimulate tissue growth. The body fluid in which the occlusive device is generally immersed, such as the moist tissue and surface within reproductive lumens may frequently suffice to create the electrical activity of minimal magnitude required for these purposes. Additional conductive fluid such as saline may be provided within the body lumen if needed to facilitate the desired electrical application.
[0015a1 According to an aspect, there is provided a contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component;
a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the reproductive lumen when in contact with conductive fluid within the reproductive lumen.
10015b] According to another aspect, there is provided an expandable device for occluding a patient's body lumen, comprising:
an expandable occluding component;
a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
10015c] According to a further aspect, there is provided a expandable device for occluding a patient's body lumen, comprising:
an expandable occluding means;
a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
[0015d] According to another aspect, there is provided a system for sterilizing a patient, comprising:
6a an occluding device having an expandable occluding component, a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
means for introducing the occluding device into a reproductive lumen of the patient;
means for expanding the occluding component of the occluding device within the patient's reproductive lumen;
means for maintaining the first and second strands within the reproductive lumen in contact with an electrolytic fluid; and means for causing an electrical activity between the first and second strands to enhance tissue growth within or onto the occluding component.
10015e] According to a further aspect, there is provided a contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component;
a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
an electrical power source;
a first electrical conductor electrically connected between the first strand and the power source; and second electrical conductor electrically connected between the second strand and the electrical power source.
6b [0015f] According to another aspect, there is provided a contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the reproductive lumen when in contact with conductive fluid within the reproductive lumen.
[0015g] According to a further aspect, there is provided an expandable device for occluding a patient's body lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self expands about the longitudinal axis, and wherein the permeable fibrous 6c member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
[0015h] According to another aspect, there is provided an expandable device for occluding a patient's body lumen, comprising:
an expandable occluding means configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding means, wherein the permeable fibrous member extends across the expandable occluding means as the expandable occluding means radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
[0015i] According to a further aspect, there is provided a system for sterilizing a patient, comprising:
an occluding device having an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second 6d configuration having a larger transverse dimension than the first configuration, a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
means for introducing the occluding device into a reproductive lumen of the patient;
means for expanding the occluding component of the occluding device within the patient's reproductive lumen;
means for maintaining the first and second strands within the reproductive lumen in contact with an electrolytic fluid ; and means for causing an electrical activity between the first and second strands to enhance tissue growth within or onto the occluding component.
10015j] According to another aspect, there is provided a contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous 6e member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
an electrical power source;
a first electrical conductor electrically connected between the first strand and the power source; and second electrical conductor electrically connected between the second strand and the electrical power source.
100161 These and other advantages of the invention will become more apparent from the following detailed description of embodiment having features of the invention, taken in conjunction with the accompanying exemplary drawings.
6f BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 is an elevational view of an occluding device embodying features of the invention with an occluding component in a first, contracted configuration.
[0018] Figure 2 is a transverse cross sectional view of the device shown in Figure 1, taken along lines 2--2.
[0019] Figure 3 is an elevational view of the device shown in Figure 1, in a second, expanded configuration.
[0020] Figure 4 is a transverse cross sectional view of the device shown in Figure 3, taken along lines 4--4.
[0021] Figure 5 is an elevational view of an alternative occluding device embodying features of the invention having bundles of fibrous strands intermittently spaced in a plurality of sections within the inner lumen of the occluding component.
[0022] Figure 6 is an elevational view of another alternative occluding device embodying features of the invention having a fibrous mesh of woven strands disposed at one end of the occluding component.
[0023] Figure 7 is a partial end view of the fibrous mesh shown in Figure 6.
[0024] Figure 8 is a longitudinal cross sectional view of the occluding device shown in Figure 6, disposed within a body lumen and illustrating tissue growth into and on the occluding component.
[0025] Figure 9 is a transverse cross sectional view of the device shown in Figure 8, taken along lines 9--9.
[0026] Figure 10 illustrates another alternative occluding device embodying features of the invention which is disposed in an unexpanded configuration within a body lumen and which has a fibrous jacket or sock on an outer surface of the occluding component.
[0027] Figure 11 illustrates the device shown in FIG. 10 in an expanded configuration.
[0028] Figure 12 is an elevational view of an occluding device embodying features of the invention with a metallic rod within the interior of the occluding component in an unexpanded configuration.
[0029] Figure 13 is an elevational view of an occlusive device of Figure 12 in its expanded configuration.
[0030] Figure 14 is a transverse cross-sectional view of a modification of the occluding device with the inner rod or wire deployed within a fibrous body in the interior of the occluding component.
[0031] Figure 15 illustrates an occluding device embodying features of the invention having a helically shaped occluding component and a helically shaped member of different metallic composition which interfits within the spacing between the turns of the helically shaped occluding component.
[0032] Figure 16 illustrates an occluding device embodying features of the invention comprising an occluding component as shown in Figure 15 with a tightly coiled helical member within the inner lumen of the occluding component.
[0033] Figure 17 is an isometric view of an alternative occluding device comprising two sheets of metal sheet or foil formed of different metals;
[0034] Figure 18 is an isometric view of an alternative occluding device having granules of different metals on its surface;
100351 Figure 19 is an elevational view of an occluding device formed of four interfitting helical coils and which have an external electrical source.
100361 Figure 20 is a schematic view of a female reproductive anatomy with the occluding device shown in Figure 19 disposed within the fallopian tube.
[00371 Figure 21 is a perspective view of an alternative occluding device having an occluding component with several spider-like members disposed along the supporting shaft.
DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION
[00381 Figures 1-4 schematically illustrate an occluding contraceptive device embodying features of the invention that generally includes an expandable stent-like occluding component or structure 11 having a first open end 12, a second open end 13, a lumen 14 extending therein and a fibrous member 15 within the inner lumen extending along a substantial length thereof. Figures 1 and 2 depict the device 10 in a delivery configuration for introduction into and advancement within the patient's reproductive lumen. Figures 3 and 4 depict the device in an expanded configuration.
[00391 As best shown in Figure 2, a fibrous member 15 is transversely disposed in the occluding structure 11. In this embodiment, in order to electrically stimulate tissue growth into or onto the occluding component 11, woven or interspersed wire element 16 is formed of one metallic material and woven or interspersed wire element 17 is formed of a second different metallic material. The metallic wires generate sufficient galvanic activity with respect to the first metallic material to stimulate tissue growth when disposed within a patient's body lumen and in contact with a body or other conductive fluid. For example, wire 16 may be made of stainless steel and wire 17 may be made of copper. While the galvanic activity generated by stainless steel and copper are very slight, the mild electrical conditions generated are sufficient to stimulate tissue ingrowth into or onto the occluding component. As previously mentioned, the copper wires 17 not only generate a galvanic response, but can provide contraceptive effects. To simplify the drawings only the two metallic strands 16 and 17 are shown. The fibrous member 15 may have a plurality of biocompatible, non-metallic strands (e.g. PET, nylon, Hytrel) to facilitate cellular growth to augment that provided by the galvanic activity.
[0040] As illustrated in Figure 4, the fibrous member 15 may be configured to expand when the occluding device 10 is expanded to the expanded configuration, so that the fibrous member 15 extends across the expanded lumen 14. The stent-like occluding component 11 has an open, lattice-type structure facilitating tissue ingrowth through the wall thereof in the expanded configuration that facilitates securing the occluding component to the wall defining the reproductive lumen as well as occluding the reproductive lumen. Preferably, the occluding component 11 is of a diameter which is about equal to or slightly larger than the dimensions of the reproductive lumen within which the contraceptive device 10 is to be disposed.
For example, for deployment within a female patient's fallopian tubes, the expanded transverse dimensions may be about 0.05 mm to about 5 mm, preferably about 0.1 to about 3 mm.
[0041] The fibrous member 15 is permeable to facilitate epithelialization or other tissue ingrowth, and the complex comprising the fibrous member with the tissue ingrowth occludes the reproductive lumen sufficiently to prevent the passage of reproductive cells therethrough.
[0042] Alternatively, the metallic strands forming in part the fibrous member 15, e.g. 16 and 17, may be formed of the same metallic material and in contact with the occluding component 11 which is formed of a different metallic material to generate sufficient galvanic activity to stimulate tissue growth.
[0043] In an alternative embodiment illustrated in FIG. 5, an occluding device 20 has an occluding component 21 (similar to that shown in Figure 1) with a plurality of fibrous members 22, 23 and 24 disposed within the inner lumen 25 of occluding component 21. The individual fibrous members 22-24 are spaced along the length of the tubular occluding component 21 with fibrous member 22 and 23 being within the ends of the occluding component and fibrous member 24 being centrally spaced.
Three fibrous members 22-24 are illustrated but a greater or lesser number of fibrous members may be disposed within the inner lumen 25. As discussed above, the individual filaments or strands of a single fibrous member may be formed of different metallic material, the metallic filaments of one fibrous member may be different metallic material from the metallic filaments of an adjacent fibrous member or the metallic filaments of one or more of the fibrous members may be formed of metallic material different from the metallic material of the occluding component 21 in order to develop sufficient galvanic activity to stimulate tissue growth into or onto the device 10.
[0044] Additional, the occluding component 21 may have one tubular section 26 formed of a different metallic material than tubular section 27 thereof. In this construction, the filaments of the mesh members may be formed of metallic material different from the metallic material of one or both of the tubular sections 23 and 24 to vary the galvanic activity along the length of the occluding component when disposed in body fluids or other electrically conductive fluids. While not shown, the tubular segments 26 and 27 may be separated and insulated by fibrous members disposed therebetween.
[0045] Figures 6 and 7 illustrate an occluding device 30 having an occluding component 31 with a permeable mesh member 32 formed of a plurality of woven strands 33 and 34 which extend across open end 35 of the occluding component and facilitate tissue growth and occlude a body lumen into which the occluding device is deployed. Some or all of the woven strands 33 may be formed of a first metallic material and some or all of woven strands 34 may be formed of a metallic material different from that of strands 33. As discussed above, the metallic strands 33 or 34 of mesh member 32 may be formed of a metallic material different from the metallic material of the occluding component 31.
[0046] Figure 7 is an end view of the device illustrated in Figure 6, illustrating the woven strands 33 and 34 forming the mesh member 32. However, the mesh member 32 may comprise a variety of suitable permeable structures which support tissue growth. For example, the mesh member 32 may be replaced with a foamed porous membrane formed of biocompatible materials. The electrical activity stimulates and enhances tissue growth as described above.
[0047] Figures 8 and 9 schematically illustrate the occluding device 30 shown in Figures 6 and 7 within a patient's reproductive lumen 35 in an expanded configuration. Tissue growth 36 is shown within the mesh member 33 disposed at the open end 37 of the occluding component 11. For purposes of simplicity, the embodiment illustrated in Figures 6-9 depicts the mesh member 32 as a single layer of woven filaments or strands 33 and 34, disposed across the opening 37 with one or more wires within the mesh member providing galvanic effect between themselves or in conjunction with the metallic material of the occluding component 31.
The mesh member 32 may be formed of a plurality of layers with the individual layers having the same or different mesh sizes. Galvanic action may be generated in the embodiment with the multilayered mesh member between the different layers, within the layers themselves and between the layers and the metallic material of the occluding component. The individual layers of the mesh member may be separated by layers of insulating material. The mesh member 30 is shown as being woven or braided to simplify the drawings. However, the member 30 may be in the form of a fibrous matt or other fibrous or porous construction.
[0048] A variety of biocompatible non-metallic materials may be used to form the mesh members 33 and 34 including polymers and treated animal tissues, e.g Dacron, Nylon, heterologous tissue, such as porcine or bovine pericardial tissue, which promote tissue growth, whereas the occluding component is constructed to provide galvanic electrical stimulation to encourage cell proliferation and thus tissue ingrowth by itself or in conjunction with one or more metallic strands in the mesh members 33 and 34. Additionally, the strands 33 and/or 34 of the mesh member may be coated or otherwise impregnated with cell growth stimulators, hormones, and/or chemicals to enhance tissue impregnation. The strands used to form the mesh member 32 are generally about 0.00025 mm to about 0.25 mm in diameter. It would be obvious that a wide variety of mesh sizes that support tissue growth may be used. For example, in one embodiment the mesh member 32 may have a mesh size of about 5 pm to about 0.05 mm, and preferably about 10 pm to about 15 pm.
Preferably, mesh members having relatively large mesh sizes are coated with the epithelialization promoter agents.
[0049] Figures 10 and 11 illustrate an embodiment having features of the invention which has an occluding device 40 (similar to that shown in Figures 6-9) having an occluding component 41 with a fibrous mass 42 provided within the inner lumen 43 of the occluding component and a fibrous jacket or sock 44 that extends along at least a section of the outer surface of the occluding component 41 and over an open end 45 of the occluding component 41. The fibrous material on the exterior, interior and an open end ensures more widespread tissue growth for occlusion.
The portion 46 of the fibrous jacket or sock 44 may be formed integral or separate from the portion 47 of the fibrous jacket which extends over the open end 45.
Galvanic activity may be generated between metallic strands in the jacket 44, between metallic strands in the jacket 44 and metallic strands within the fibrous body 42 within inner lumen 43 or metallic strands within either the fibrous body 42 or the jacket or sock 44 or both and the occluding component. The fibrous material of the fibrous body 42 and that of the jacket or sock 44 are permeable to allow for tissue ingrowth when the occluding component 41 is expanded into contact with a wall of the reproductive lumen 46 as shown schematically in Figure 11. The occluding component 41 is preferably self expanded within the reproductive lumen 48 due to the presence of the fibrous body 42 within the inner lumen 43.
[0050] Figures 12-14 illustrate an alternative occluding device 50 embodying features of the invention and having a tubular, stent-like occluding component 51 in the form of a metallic hypotube 52 with slots 53 cut into the wall of the hypotube to allow expansion of the occluding component to an expanded configuration with larger transverse dimensions as shown in Figure 13. In this construction, a rod or wire 54 is longitudinally disposed within the inner lumen 55 of the occluding component 51. The galvanic activity may be created by constructing all or part of the occluding component 51 of one metal and the rod or wire 54 disposed within the inner lumen 55 of the occluding component formed of a different metal. The occluding component 51 may optionally have barbed or hook like projections 56 that aid in retention of the occluding component 51 within a reproductive lumen.
While the projections 56 are shown in Figure 13 inclined toward one end of the occluding component, they may be inclined toward either or both ends of the occluding component. The metal rod or wire 54 may be suspended within a fibrous body 57 as shown in Figure 14. The fibrous body 57 may be formed of metallic or non-metallic strands 58, e.g. polyethylene terephthalate (PET). These fibrous strands 58 nay be formed of insulating material to isolate the rod or wire 54 from the occluding component 51. However, the fibrous body 57 may have one or more metallic strands which are formed of different metallic material from either the rod or wire 54 or the occluding component 51.
[0051] Figure 15 illustrates an alternative occluding device 60 having features of the invention. In this embodiment the occluding device 60 comprises an occluding component 61 formed into a helically shaped coil 62 of a first metallic material with space 63 between individual turns of the helically shaped coil. A second helically shaped coil 64 formed of a second metallic material different from the first metallic material is fitted into the space 63 of the first coil 62 to generate galvanic activity to enhance tissue growth into and/or on the occluding component 61. The contacting surfaces of the helically shaped coils 62 and 64 may be insulated (not shown) to varying degrees to control the level of galvanic activity to achieve the desired tissue ingrowth. As previously described, a fibrous body (not shown) may be disposed within the inner lumen 65 of the occluding component 61 or a fibrous jacket or sock (such as shown in Figures 10 and 11) may be provided on the exterior of the occluding component to further enhance tissue growth. The helical coils 62 and may be balloon or self expandable for deployment within a patient's body lumen.
[0052] Another occluding device 70 embodying features of the invention is depicted in Figure 16, which has an occluding component 71 formed of a helically shaped coil structure 72 similar to the occluding component 61 shown in Figure and a smaller diameter helical coil 73 disposed within the inner lumen 74 of the occluding component 71. The occluding component 71 is expandable and preferably is formed of shape memory or superelastic metallic material such as NiTi alloy like NITINOL. The helically shaped coil 72 may be suspended within the inner lumen 73 by a mesh or other fibrous body (not shown) such as discussed above and shown in Figure 14. The inner coil 72 may be formed of metallic material different from the metallic material of the occluding component to generate galvanic activity which stimulates tissue growth into and onto the occluding component 71 of device 70. The strands of a fibrous body disposed within the inner lumen 73 may be metallic strands and add to the electrical activity.
[0053] Another occluding device 80 embodying features of the invention is shown in Figure 17. In this embodiment, the occluding device 80 has an occluding component 81 having two layers 82 and 83 formed of different metals rolled together. There may be a layer of insulative material between the two metal layers (not shown) to enhance the galvanic effects and to localize the ionic exchange to the edges of the occluding component 81.
[0054] Yet another construction embodying features of the invention is shown in Figure 18. The occluding device 90 of this embodiment has an occluding component 91 which is a tubular element 92 that may or may not be expandable against the walls of the body lumen with particles 93 and 94 formed of different metallic material on the surface of the tubular member. The tubular element 92 is generally an insulator, and when the device is implanted in a reproductive lumen and in contact with body fluids which act as electrolytes, a voltage differential exists between the different metal particles which is sufficient to encourage tissue ingrowth to occur, and to thus enhance the occlusion of the reproductive lumen into which the occluding device 90 is deployed.
[0055] In addition to the stimulation of tissue growth by galvanic activity as discussed above, a voltage may be impressed against the tissue of a reproductive lumen such as a fallopian tube or vas deferens to enhance tissue growth into or onto an occluding device deployed within the reproductive lumen such as described herein. A suitable occluding device 100 is shown in Figures 19 and 20. As shown in Figure 19 the suitable occluding device 100 comprises an occluding component formed of four separate interfitting helical coils 102, 103, 104 and 105.
Helical coils 102 and 104 are electrically connected by conductors 106 and 107 respectively to opposite poles 108 and 109 of a power source 110 (e.g. battery). The helical coils 102 and 104 act as electrodes. Helical coils 103 and 105 are insulators. In this way the two helical coils 102 and 104 are insulated from each other along their length, and conduct electrical current to each other through the tissue in contact with metallic portions of the occluding component 101.
[0056] Figure 20 illustrates the occluding device 100 deployed within a patient's fallopian tube 111. The conductors 106 and 107 extend through the patient's uterine cavity 112 and vaginal canal 113 and are electrically connected to battery 110. The application of electrical power from the external source 110 is usually intermittent. For example, electrical power from the battery 110 can be applied for about one hour a day for the first five days and may only be needed to stimulate initial tissue ingrowth. This may be monitored and the application of the electrical power discontinued when the tissue ingrowth is sufficiently complete. This electrical stimulation is very helpful in initiating effective tissue ingrowth at the inception of the implantation of the occlusive device. Essentially the same basic system may be employed to occlude a male reproductive lumen such as a vas deferens.
[0057] Another occluding device 130 is shown in Figure 21 which has features of the invention. The occluding device 130 has an occluding component 131 with an elongated shaft 132 and spider-like expandable elements 133, 134 and 135. The expandable elements are formed of different metallic materials than the expandable element adjacent thereto to provide the desired galvanic activity. The junctions between the portions of differing metallic materials are shown at locations 136 and 137. The junctions 136 and 137 may be formed mechanically, metallurgically, adhesively, by laser welding. In those situations in which the portions of the shaft are difficult to join, a cylindrical collar may be employed to joint the mating ends of the shaft sections. Alternatively, the occluding component 131 may be formed entirely of a first metallic material and a collar 138 formed of a second different metallic material may be secured to one or more of the expandable legs 139 of expandable spider-like element 135 or the shaft 132 to provide the galvanic activity required to enhance tissue growth. One or more of the spider-like elements 133-may have a fibrous member (not shown) such as shown in Figure 5.
[0058] Various means may be employed to secure an occluding device embodying features of the invention within a reproductive or other lumen other than as described above. For example, mechanical, adhesive or other anchoring means may be employed to secure the expanded occluding device to the vessel wall defining the body lumen. Means to secure a stent or prosthetic device to an aortic or arterial wall, such as described in U.S. Pat. No. 4,140,126; U.S. Pat. No.
4,562,596;
In some situations, one of the metallic elements or one group of the metallic elements configured for developing electrical activity in the body lumen, may be formed of copper to provide further contraceptive action in addition to the occlusion of the lumen. Additionally, therapeutic or diagnostic agents by be employed with the occluding device for contraceptive or other uses, e.g. antibiotics, chemotherapy. For example, the occluding component can be coated with a polymer having impregnated therein an agent such as a drug, enzyme or protein, for inducing or promoting tissue growth. In yet another refinement, the surface of the occluding component may be plated with or otherwise incorporated with an elutable inflammatory material to produce an inflammatory response in the tissue of the wall defining the body lumen, which further contributes to the obstruction of the lumen.
Inflammatory materials include copper or copper alloys. Other inflammatory materials, such as radioactive materials (emitting alpha, beta or gamma particles) may be used alone or in conjunction with other inflammatory materials.
[00101 The occluding device embodying features of the invention preferably has an occluding component that at least in part has a first delivery configuration with small transverse dimensions suitable for delivery to the chosen location in a reproductive or other body lumen and a second expanded configuration larger in transverse dimensions than the first configuration to facilitate securing the occluding component of the device within the reproductive or body lumen. The occluding component of the device may be balloon expandable or self-expandable from the first configuration to the second configuration to occlude the body lumen.
[00111 The occluding device may be a tubular stent-like structure, such as described in U.S. Patent Applications Nos. 7,073,504, filed on December 18, 1996, 6,096,052, filed on July 8, 1998, 6,432,116, filed on December 21 , 1999 and 7,694,693, filed on June 27, 2003. Alternatively, the occluding device may have one or more spider-like constructions shown in co-pending U.S. Publication No.
2005/0085844, filed on December 24, 2003. The occluding component will generally be about I to about 5 mm, preferably about 2 to about 4 mm in transverse dimension in the expanded configuration and will generally be about 0.5 to about 8 cm, preferably about 1.5 to about 4 cm in length. While the description herein is focused on the use of only one occluding device, two or more occluding devices may be employed in a reproductive or other body lumen.
[0012] The occluding device having features of the invention is placed in a contracted configuration to facilitate introduction and advancement of the device within the reproductive lumen or other body lumen, usually within an inner lumen of a delivery sheath. Once in the desired position within a patient's body lumen, the delivery sheath is withdrawn while the occluding device is held in-place at the desired location. The sheath withdrawal exposes the occluding device at the chosen site and the occluding device is expanded either by inflating a balloon within the inner lumen of the occluding component or from self expansion due to the nature and condition of the metallic material of which the occluding component is made. An exposed portion of the occluding device may expand or be expanded before the entire occluding device is discharged from the delivery sheath. Self-expanding occluding components of the device may be formed of superelastic NITINOL with an austenite phase that is stable at body temperature, i.e. the material of the occluding component will not transform from the austenite phase to a martensite phase at body temperature except by the application of stress. The occluding component may also be formed of a heat expandable metallic material such as shape memory NITINOL
which has a stable martensite phase at body temperature and which returns to a remembered expanded condition when heated above the martensite-to-austenite transition temperature causing the occluding component to expand within the patient's body lumen.
[0013] The metallic elements associated with the occluding component and which generate the electrical activity within the body lumen to stimulate tissue growth may be formed at least in part of suitable conductive metallic materials such as stainless steel, NiTi alloy, platinum, tantalum, copper and gold. Other conductive materials are suitable. Moreover, the metallic elements may be part of the occluding component or be separate elements which are directly or indirectly secured to the occluding component. They may be electrically connected through one or more electrical conductors or even the occluding component itself.
100141 Fibrous strands or bundles thereof, fibrous mesh, porous polymer bodies and the like may be disposed within or on the occluding device to facilitate tissue ingrowth in addition to the electrical stimulation of tissue growth.
The fibrous bundle, fibrous mesh or porous polymeric bodies may be disposed in either balloon expandable or self-expanding occluding devices. However, mesh, fibrous or porous polymeric material within the inner lumen of balloon expandable occluding components can make balloon placement within the inner lumen difficult.
[0015] To generate the electrical activity, in general, two different metal elements which are electrically connected are immersed in an electrolyte, such as body fluids or saline or both to stimulate tissue growth. The body fluid in which the occlusive device is generally immersed, such as the moist tissue and surface within reproductive lumens may frequently suffice to create the electrical activity of minimal magnitude required for these purposes. Additional conductive fluid such as saline may be provided within the body lumen if needed to facilitate the desired electrical application.
[0015a1 According to an aspect, there is provided a contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component;
a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the reproductive lumen when in contact with conductive fluid within the reproductive lumen.
10015b] According to another aspect, there is provided an expandable device for occluding a patient's body lumen, comprising:
an expandable occluding component;
a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
10015c] According to a further aspect, there is provided a expandable device for occluding a patient's body lumen, comprising:
an expandable occluding means;
a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
[0015d] According to another aspect, there is provided a system for sterilizing a patient, comprising:
6a an occluding device having an expandable occluding component, a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
means for introducing the occluding device into a reproductive lumen of the patient;
means for expanding the occluding component of the occluding device within the patient's reproductive lumen;
means for maintaining the first and second strands within the reproductive lumen in contact with an electrolytic fluid; and means for causing an electrical activity between the first and second strands to enhance tissue growth within or onto the occluding component.
10015e] According to a further aspect, there is provided a contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component;
a permeable fibrous member comprising a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
an electrical power source;
a first electrical conductor electrically connected between the first strand and the power source; and second electrical conductor electrically connected between the second strand and the electrical power source.
6b [0015f] According to another aspect, there is provided a contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the reproductive lumen when in contact with conductive fluid within the reproductive lumen.
[0015g] According to a further aspect, there is provided an expandable device for occluding a patient's body lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self expands about the longitudinal axis, and wherein the permeable fibrous 6c member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
[0015h] According to another aspect, there is provided an expandable device for occluding a patient's body lumen, comprising:
an expandable occluding means configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding means, wherein the permeable fibrous member extends across the expandable occluding means as the expandable occluding means radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
[0015i] According to a further aspect, there is provided a system for sterilizing a patient, comprising:
an occluding device having an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second 6d configuration having a larger transverse dimension than the first configuration, a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
means for introducing the occluding device into a reproductive lumen of the patient;
means for expanding the occluding component of the occluding device within the patient's reproductive lumen;
means for maintaining the first and second strands within the reproductive lumen in contact with an electrolytic fluid ; and means for causing an electrical activity between the first and second strands to enhance tissue growth within or onto the occluding component.
10015j] According to another aspect, there is provided a contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous 6e member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
an electrical power source;
a first electrical conductor electrically connected between the first strand and the power source; and second electrical conductor electrically connected between the second strand and the electrical power source.
100161 These and other advantages of the invention will become more apparent from the following detailed description of embodiment having features of the invention, taken in conjunction with the accompanying exemplary drawings.
6f BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 is an elevational view of an occluding device embodying features of the invention with an occluding component in a first, contracted configuration.
[0018] Figure 2 is a transverse cross sectional view of the device shown in Figure 1, taken along lines 2--2.
[0019] Figure 3 is an elevational view of the device shown in Figure 1, in a second, expanded configuration.
[0020] Figure 4 is a transverse cross sectional view of the device shown in Figure 3, taken along lines 4--4.
[0021] Figure 5 is an elevational view of an alternative occluding device embodying features of the invention having bundles of fibrous strands intermittently spaced in a plurality of sections within the inner lumen of the occluding component.
[0022] Figure 6 is an elevational view of another alternative occluding device embodying features of the invention having a fibrous mesh of woven strands disposed at one end of the occluding component.
[0023] Figure 7 is a partial end view of the fibrous mesh shown in Figure 6.
[0024] Figure 8 is a longitudinal cross sectional view of the occluding device shown in Figure 6, disposed within a body lumen and illustrating tissue growth into and on the occluding component.
[0025] Figure 9 is a transverse cross sectional view of the device shown in Figure 8, taken along lines 9--9.
[0026] Figure 10 illustrates another alternative occluding device embodying features of the invention which is disposed in an unexpanded configuration within a body lumen and which has a fibrous jacket or sock on an outer surface of the occluding component.
[0027] Figure 11 illustrates the device shown in FIG. 10 in an expanded configuration.
[0028] Figure 12 is an elevational view of an occluding device embodying features of the invention with a metallic rod within the interior of the occluding component in an unexpanded configuration.
[0029] Figure 13 is an elevational view of an occlusive device of Figure 12 in its expanded configuration.
[0030] Figure 14 is a transverse cross-sectional view of a modification of the occluding device with the inner rod or wire deployed within a fibrous body in the interior of the occluding component.
[0031] Figure 15 illustrates an occluding device embodying features of the invention having a helically shaped occluding component and a helically shaped member of different metallic composition which interfits within the spacing between the turns of the helically shaped occluding component.
[0032] Figure 16 illustrates an occluding device embodying features of the invention comprising an occluding component as shown in Figure 15 with a tightly coiled helical member within the inner lumen of the occluding component.
[0033] Figure 17 is an isometric view of an alternative occluding device comprising two sheets of metal sheet or foil formed of different metals;
[0034] Figure 18 is an isometric view of an alternative occluding device having granules of different metals on its surface;
100351 Figure 19 is an elevational view of an occluding device formed of four interfitting helical coils and which have an external electrical source.
100361 Figure 20 is a schematic view of a female reproductive anatomy with the occluding device shown in Figure 19 disposed within the fallopian tube.
[00371 Figure 21 is a perspective view of an alternative occluding device having an occluding component with several spider-like members disposed along the supporting shaft.
DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION
[00381 Figures 1-4 schematically illustrate an occluding contraceptive device embodying features of the invention that generally includes an expandable stent-like occluding component or structure 11 having a first open end 12, a second open end 13, a lumen 14 extending therein and a fibrous member 15 within the inner lumen extending along a substantial length thereof. Figures 1 and 2 depict the device 10 in a delivery configuration for introduction into and advancement within the patient's reproductive lumen. Figures 3 and 4 depict the device in an expanded configuration.
[00391 As best shown in Figure 2, a fibrous member 15 is transversely disposed in the occluding structure 11. In this embodiment, in order to electrically stimulate tissue growth into or onto the occluding component 11, woven or interspersed wire element 16 is formed of one metallic material and woven or interspersed wire element 17 is formed of a second different metallic material. The metallic wires generate sufficient galvanic activity with respect to the first metallic material to stimulate tissue growth when disposed within a patient's body lumen and in contact with a body or other conductive fluid. For example, wire 16 may be made of stainless steel and wire 17 may be made of copper. While the galvanic activity generated by stainless steel and copper are very slight, the mild electrical conditions generated are sufficient to stimulate tissue ingrowth into or onto the occluding component. As previously mentioned, the copper wires 17 not only generate a galvanic response, but can provide contraceptive effects. To simplify the drawings only the two metallic strands 16 and 17 are shown. The fibrous member 15 may have a plurality of biocompatible, non-metallic strands (e.g. PET, nylon, Hytrel) to facilitate cellular growth to augment that provided by the galvanic activity.
[0040] As illustrated in Figure 4, the fibrous member 15 may be configured to expand when the occluding device 10 is expanded to the expanded configuration, so that the fibrous member 15 extends across the expanded lumen 14. The stent-like occluding component 11 has an open, lattice-type structure facilitating tissue ingrowth through the wall thereof in the expanded configuration that facilitates securing the occluding component to the wall defining the reproductive lumen as well as occluding the reproductive lumen. Preferably, the occluding component 11 is of a diameter which is about equal to or slightly larger than the dimensions of the reproductive lumen within which the contraceptive device 10 is to be disposed.
For example, for deployment within a female patient's fallopian tubes, the expanded transverse dimensions may be about 0.05 mm to about 5 mm, preferably about 0.1 to about 3 mm.
[0041] The fibrous member 15 is permeable to facilitate epithelialization or other tissue ingrowth, and the complex comprising the fibrous member with the tissue ingrowth occludes the reproductive lumen sufficiently to prevent the passage of reproductive cells therethrough.
[0042] Alternatively, the metallic strands forming in part the fibrous member 15, e.g. 16 and 17, may be formed of the same metallic material and in contact with the occluding component 11 which is formed of a different metallic material to generate sufficient galvanic activity to stimulate tissue growth.
[0043] In an alternative embodiment illustrated in FIG. 5, an occluding device 20 has an occluding component 21 (similar to that shown in Figure 1) with a plurality of fibrous members 22, 23 and 24 disposed within the inner lumen 25 of occluding component 21. The individual fibrous members 22-24 are spaced along the length of the tubular occluding component 21 with fibrous member 22 and 23 being within the ends of the occluding component and fibrous member 24 being centrally spaced.
Three fibrous members 22-24 are illustrated but a greater or lesser number of fibrous members may be disposed within the inner lumen 25. As discussed above, the individual filaments or strands of a single fibrous member may be formed of different metallic material, the metallic filaments of one fibrous member may be different metallic material from the metallic filaments of an adjacent fibrous member or the metallic filaments of one or more of the fibrous members may be formed of metallic material different from the metallic material of the occluding component 21 in order to develop sufficient galvanic activity to stimulate tissue growth into or onto the device 10.
[0044] Additional, the occluding component 21 may have one tubular section 26 formed of a different metallic material than tubular section 27 thereof. In this construction, the filaments of the mesh members may be formed of metallic material different from the metallic material of one or both of the tubular sections 23 and 24 to vary the galvanic activity along the length of the occluding component when disposed in body fluids or other electrically conductive fluids. While not shown, the tubular segments 26 and 27 may be separated and insulated by fibrous members disposed therebetween.
[0045] Figures 6 and 7 illustrate an occluding device 30 having an occluding component 31 with a permeable mesh member 32 formed of a plurality of woven strands 33 and 34 which extend across open end 35 of the occluding component and facilitate tissue growth and occlude a body lumen into which the occluding device is deployed. Some or all of the woven strands 33 may be formed of a first metallic material and some or all of woven strands 34 may be formed of a metallic material different from that of strands 33. As discussed above, the metallic strands 33 or 34 of mesh member 32 may be formed of a metallic material different from the metallic material of the occluding component 31.
[0046] Figure 7 is an end view of the device illustrated in Figure 6, illustrating the woven strands 33 and 34 forming the mesh member 32. However, the mesh member 32 may comprise a variety of suitable permeable structures which support tissue growth. For example, the mesh member 32 may be replaced with a foamed porous membrane formed of biocompatible materials. The electrical activity stimulates and enhances tissue growth as described above.
[0047] Figures 8 and 9 schematically illustrate the occluding device 30 shown in Figures 6 and 7 within a patient's reproductive lumen 35 in an expanded configuration. Tissue growth 36 is shown within the mesh member 33 disposed at the open end 37 of the occluding component 11. For purposes of simplicity, the embodiment illustrated in Figures 6-9 depicts the mesh member 32 as a single layer of woven filaments or strands 33 and 34, disposed across the opening 37 with one or more wires within the mesh member providing galvanic effect between themselves or in conjunction with the metallic material of the occluding component 31.
The mesh member 32 may be formed of a plurality of layers with the individual layers having the same or different mesh sizes. Galvanic action may be generated in the embodiment with the multilayered mesh member between the different layers, within the layers themselves and between the layers and the metallic material of the occluding component. The individual layers of the mesh member may be separated by layers of insulating material. The mesh member 30 is shown as being woven or braided to simplify the drawings. However, the member 30 may be in the form of a fibrous matt or other fibrous or porous construction.
[0048] A variety of biocompatible non-metallic materials may be used to form the mesh members 33 and 34 including polymers and treated animal tissues, e.g Dacron, Nylon, heterologous tissue, such as porcine or bovine pericardial tissue, which promote tissue growth, whereas the occluding component is constructed to provide galvanic electrical stimulation to encourage cell proliferation and thus tissue ingrowth by itself or in conjunction with one or more metallic strands in the mesh members 33 and 34. Additionally, the strands 33 and/or 34 of the mesh member may be coated or otherwise impregnated with cell growth stimulators, hormones, and/or chemicals to enhance tissue impregnation. The strands used to form the mesh member 32 are generally about 0.00025 mm to about 0.25 mm in diameter. It would be obvious that a wide variety of mesh sizes that support tissue growth may be used. For example, in one embodiment the mesh member 32 may have a mesh size of about 5 pm to about 0.05 mm, and preferably about 10 pm to about 15 pm.
Preferably, mesh members having relatively large mesh sizes are coated with the epithelialization promoter agents.
[0049] Figures 10 and 11 illustrate an embodiment having features of the invention which has an occluding device 40 (similar to that shown in Figures 6-9) having an occluding component 41 with a fibrous mass 42 provided within the inner lumen 43 of the occluding component and a fibrous jacket or sock 44 that extends along at least a section of the outer surface of the occluding component 41 and over an open end 45 of the occluding component 41. The fibrous material on the exterior, interior and an open end ensures more widespread tissue growth for occlusion.
The portion 46 of the fibrous jacket or sock 44 may be formed integral or separate from the portion 47 of the fibrous jacket which extends over the open end 45.
Galvanic activity may be generated between metallic strands in the jacket 44, between metallic strands in the jacket 44 and metallic strands within the fibrous body 42 within inner lumen 43 or metallic strands within either the fibrous body 42 or the jacket or sock 44 or both and the occluding component. The fibrous material of the fibrous body 42 and that of the jacket or sock 44 are permeable to allow for tissue ingrowth when the occluding component 41 is expanded into contact with a wall of the reproductive lumen 46 as shown schematically in Figure 11. The occluding component 41 is preferably self expanded within the reproductive lumen 48 due to the presence of the fibrous body 42 within the inner lumen 43.
[0050] Figures 12-14 illustrate an alternative occluding device 50 embodying features of the invention and having a tubular, stent-like occluding component 51 in the form of a metallic hypotube 52 with slots 53 cut into the wall of the hypotube to allow expansion of the occluding component to an expanded configuration with larger transverse dimensions as shown in Figure 13. In this construction, a rod or wire 54 is longitudinally disposed within the inner lumen 55 of the occluding component 51. The galvanic activity may be created by constructing all or part of the occluding component 51 of one metal and the rod or wire 54 disposed within the inner lumen 55 of the occluding component formed of a different metal. The occluding component 51 may optionally have barbed or hook like projections 56 that aid in retention of the occluding component 51 within a reproductive lumen.
While the projections 56 are shown in Figure 13 inclined toward one end of the occluding component, they may be inclined toward either or both ends of the occluding component. The metal rod or wire 54 may be suspended within a fibrous body 57 as shown in Figure 14. The fibrous body 57 may be formed of metallic or non-metallic strands 58, e.g. polyethylene terephthalate (PET). These fibrous strands 58 nay be formed of insulating material to isolate the rod or wire 54 from the occluding component 51. However, the fibrous body 57 may have one or more metallic strands which are formed of different metallic material from either the rod or wire 54 or the occluding component 51.
[0051] Figure 15 illustrates an alternative occluding device 60 having features of the invention. In this embodiment the occluding device 60 comprises an occluding component 61 formed into a helically shaped coil 62 of a first metallic material with space 63 between individual turns of the helically shaped coil. A second helically shaped coil 64 formed of a second metallic material different from the first metallic material is fitted into the space 63 of the first coil 62 to generate galvanic activity to enhance tissue growth into and/or on the occluding component 61. The contacting surfaces of the helically shaped coils 62 and 64 may be insulated (not shown) to varying degrees to control the level of galvanic activity to achieve the desired tissue ingrowth. As previously described, a fibrous body (not shown) may be disposed within the inner lumen 65 of the occluding component 61 or a fibrous jacket or sock (such as shown in Figures 10 and 11) may be provided on the exterior of the occluding component to further enhance tissue growth. The helical coils 62 and may be balloon or self expandable for deployment within a patient's body lumen.
[0052] Another occluding device 70 embodying features of the invention is depicted in Figure 16, which has an occluding component 71 formed of a helically shaped coil structure 72 similar to the occluding component 61 shown in Figure and a smaller diameter helical coil 73 disposed within the inner lumen 74 of the occluding component 71. The occluding component 71 is expandable and preferably is formed of shape memory or superelastic metallic material such as NiTi alloy like NITINOL. The helically shaped coil 72 may be suspended within the inner lumen 73 by a mesh or other fibrous body (not shown) such as discussed above and shown in Figure 14. The inner coil 72 may be formed of metallic material different from the metallic material of the occluding component to generate galvanic activity which stimulates tissue growth into and onto the occluding component 71 of device 70. The strands of a fibrous body disposed within the inner lumen 73 may be metallic strands and add to the electrical activity.
[0053] Another occluding device 80 embodying features of the invention is shown in Figure 17. In this embodiment, the occluding device 80 has an occluding component 81 having two layers 82 and 83 formed of different metals rolled together. There may be a layer of insulative material between the two metal layers (not shown) to enhance the galvanic effects and to localize the ionic exchange to the edges of the occluding component 81.
[0054] Yet another construction embodying features of the invention is shown in Figure 18. The occluding device 90 of this embodiment has an occluding component 91 which is a tubular element 92 that may or may not be expandable against the walls of the body lumen with particles 93 and 94 formed of different metallic material on the surface of the tubular member. The tubular element 92 is generally an insulator, and when the device is implanted in a reproductive lumen and in contact with body fluids which act as electrolytes, a voltage differential exists between the different metal particles which is sufficient to encourage tissue ingrowth to occur, and to thus enhance the occlusion of the reproductive lumen into which the occluding device 90 is deployed.
[0055] In addition to the stimulation of tissue growth by galvanic activity as discussed above, a voltage may be impressed against the tissue of a reproductive lumen such as a fallopian tube or vas deferens to enhance tissue growth into or onto an occluding device deployed within the reproductive lumen such as described herein. A suitable occluding device 100 is shown in Figures 19 and 20. As shown in Figure 19 the suitable occluding device 100 comprises an occluding component formed of four separate interfitting helical coils 102, 103, 104 and 105.
Helical coils 102 and 104 are electrically connected by conductors 106 and 107 respectively to opposite poles 108 and 109 of a power source 110 (e.g. battery). The helical coils 102 and 104 act as electrodes. Helical coils 103 and 105 are insulators. In this way the two helical coils 102 and 104 are insulated from each other along their length, and conduct electrical current to each other through the tissue in contact with metallic portions of the occluding component 101.
[0056] Figure 20 illustrates the occluding device 100 deployed within a patient's fallopian tube 111. The conductors 106 and 107 extend through the patient's uterine cavity 112 and vaginal canal 113 and are electrically connected to battery 110. The application of electrical power from the external source 110 is usually intermittent. For example, electrical power from the battery 110 can be applied for about one hour a day for the first five days and may only be needed to stimulate initial tissue ingrowth. This may be monitored and the application of the electrical power discontinued when the tissue ingrowth is sufficiently complete. This electrical stimulation is very helpful in initiating effective tissue ingrowth at the inception of the implantation of the occlusive device. Essentially the same basic system may be employed to occlude a male reproductive lumen such as a vas deferens.
[0057] Another occluding device 130 is shown in Figure 21 which has features of the invention. The occluding device 130 has an occluding component 131 with an elongated shaft 132 and spider-like expandable elements 133, 134 and 135. The expandable elements are formed of different metallic materials than the expandable element adjacent thereto to provide the desired galvanic activity. The junctions between the portions of differing metallic materials are shown at locations 136 and 137. The junctions 136 and 137 may be formed mechanically, metallurgically, adhesively, by laser welding. In those situations in which the portions of the shaft are difficult to join, a cylindrical collar may be employed to joint the mating ends of the shaft sections. Alternatively, the occluding component 131 may be formed entirely of a first metallic material and a collar 138 formed of a second different metallic material may be secured to one or more of the expandable legs 139 of expandable spider-like element 135 or the shaft 132 to provide the galvanic activity required to enhance tissue growth. One or more of the spider-like elements 133-may have a fibrous member (not shown) such as shown in Figure 5.
[0058] Various means may be employed to secure an occluding device embodying features of the invention within a reproductive or other lumen other than as described above. For example, mechanical, adhesive or other anchoring means may be employed to secure the expanded occluding device to the vessel wall defining the body lumen. Means to secure a stent or prosthetic device to an aortic or arterial wall, such as described in U.S. Pat. No. 4,140,126; U.S. Pat. No.
4,562,596;
U.S. Pat. No. 4,577,631; U.S. Pat. No. 4,787,899; U.S. Pat. No. 5,104,399;
U.S. Pat.
No. 5,167,614; U.S. Pat. No. 5,275,622; U.S. Pat. No. 5,456,713; and U.S. Pat.
No.
5,489,295 may be useful in this regard.
[00591 The occluding component of devices embodying features of the invention are preferably formed of a superelastic material such as NiTi alloy so as to provide a controlled force on the body lumen during expansion. Additionally, the surface of the occluding components may be configured to further facilitate epithelial and other tissue ingrowth. Suitable surface treatments include plasma etching, sand blasting, machining and other treatments to roughen the surface. The surface of the occluding component may be coated or seeded to spur epithelialization.
100601 The fibrous and mesh members may be connected to the occluding component by a variety of suitable means including tying, sutures, clips, adhesives, heat bonding, or solvent bonding.
[00611 Various modifications and improvements may be made to the present invention without departing from the scope thereof For example, while the invention has been discussed primarily in terms of occluding a reproductive body lumen, the occluding device may be used to occlude a variety of body lumens or passageways such as arteries or veins in a variety of situations, the nidus of an arterial-venous malformation, patent ductus arteriosis in infants, as well as arteries leading to benign or cancerous tumors.
[00621 Additionally, other occluding devices and delivery devices that may be utilized are disclosed in U.S. Patent Nos. 7,073,504, filed on December 18, 1996;
6,096,052, filed on July 8, 1998; 6,432,116, filed on December 21, 1999; U.S.
Publication No. 2005/0085844, filed on December 24, 2004; and U.S. Patent No.
7,694,683, filed on June 27, 2003.
U.S. Pat.
No. 5,167,614; U.S. Pat. No. 5,275,622; U.S. Pat. No. 5,456,713; and U.S. Pat.
No.
5,489,295 may be useful in this regard.
[00591 The occluding component of devices embodying features of the invention are preferably formed of a superelastic material such as NiTi alloy so as to provide a controlled force on the body lumen during expansion. Additionally, the surface of the occluding components may be configured to further facilitate epithelial and other tissue ingrowth. Suitable surface treatments include plasma etching, sand blasting, machining and other treatments to roughen the surface. The surface of the occluding component may be coated or seeded to spur epithelialization.
100601 The fibrous and mesh members may be connected to the occluding component by a variety of suitable means including tying, sutures, clips, adhesives, heat bonding, or solvent bonding.
[00611 Various modifications and improvements may be made to the present invention without departing from the scope thereof For example, while the invention has been discussed primarily in terms of occluding a reproductive body lumen, the occluding device may be used to occlude a variety of body lumens or passageways such as arteries or veins in a variety of situations, the nidus of an arterial-venous malformation, patent ductus arteriosis in infants, as well as arteries leading to benign or cancerous tumors.
[00621 Additionally, other occluding devices and delivery devices that may be utilized are disclosed in U.S. Patent Nos. 7,073,504, filed on December 18, 1996;
6,096,052, filed on July 8, 1998; 6,432,116, filed on December 21, 1999; U.S.
Publication No. 2005/0085844, filed on December 24, 2004; and U.S. Patent No.
7,694,683, filed on June 27, 2003.
[0063) Although individual features of the invention may be described with respect to one or more of the embodiments but not in other embodiments, it should be readily apparent that individual features of one embodiment having features of the invention can be combined with any or all the features of one or more of other embodiments.
[00641 Terms such a "element", "member", "device", "section", "portion", "component", "means", "step" and words of similar import, when used in the following claims, shall not be construed as invoking the provisions of 35 U.S.C.
112(6) unless the claims expressly use the term "means" followed by a particular function without specific structure or expressly use the term "step" or "steps"
followed by a particular function without specific action.
[00641 Terms such a "element", "member", "device", "section", "portion", "component", "means", "step" and words of similar import, when used in the following claims, shall not be construed as invoking the provisions of 35 U.S.C.
112(6) unless the claims expressly use the term "means" followed by a particular function without specific structure or expressly use the term "step" or "steps"
followed by a particular function without specific action.
Claims (18)
1. A contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the reproductive lumen when in contact with conductive fluid within the reproductive lumen.
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the reproductive lumen when in contact with conductive fluid within the reproductive lumen.
2. The device of claim 1 wherein the tissue growth is into the occluding component.
3. The device of claim 1 wherein the tissue growth is onto the occluding component.
4. The device of claim 1 wherein the occluding component is a stent.
5. The device of claim 1 wherein the first and second strands are interspersed.
6. The device of claim 1 wherein one of the first or second strands is formed at least in part of copper.
7. The device of claim 1 wherein one of the first and second strands is formed at least in part of iron.
8. The device of claim 1 wherein the plurality of strands are in a mesh construction.
9. The device of claim 1 wherein the permeable fibrous member is disposed within an inner lumen of the occluding component.
10. The device of claim 1 wherein the permeable fibrous material is disposed on the occluding component.
11. The device of claim 1 wherein the occluding component has an elongated shaft and a plurality of expandable spider like elements are provided along the elongated shaft.
12. The device of claim 1 wherein the occluding component comprises a spider like element.
13. The device of claim I wherein the first and second strands are configured to be electrically connected to an electrical power source.
14. The device of claim 13 wherein the electrical power source is a battery.
15. An expandable device for occluding a patient's body lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
16. An expandable device for occluding a patient's body lumen, comprising:
an expandable occluding means configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding means, wherein the permeable fibrous member extends across the expandable occluding means as the expandable occluding means radially self-expands about the longitudinal axis, and wherein the permeable fibrous, member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
an expandable occluding means configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding means, wherein the permeable fibrous member extends across the expandable occluding means as the expandable occluding means radially self-expands about the longitudinal axis, and wherein the permeable fibrous, member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material; and wherein the first and second strands are configured to generate sufficient electrical activity between the first and second strands to stimulate tissue growth within the body lumen when in contact with conductive fluid within the body lumen.
17. A system for sterilizing a patient, comprising:
an occluding device having an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration, a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
means for introducing the occluding device into a reproductive lumen of the patient;
means for expanding the occluding component of the occluding device within the patient's reproductive lumen;
means for maintaining the first and second strands within the reproductive lumen in contact with an electrolytic fluid ; and means for causing an electrical activity between the first and second strands to enhance tissue growth within or onto the occluding component.
an occluding device having an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration, a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
means for introducing the occluding device into a reproductive lumen of the patient;
means for expanding the occluding component of the occluding device within the patient's reproductive lumen;
means for maintaining the first and second strands within the reproductive lumen in contact with an electrolytic fluid ; and means for causing an electrical activity between the first and second strands to enhance tissue growth within or onto the occluding component.
18. A contraceptive device for occluding a patient's reproductive lumen, comprising:
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
an electrical power source;
a first electrical conductor electrically connected between the first strand and the power source; and second electrical conductor electrically connected between the second strand and the electrical power source.
an expandable occluding component configured to radially self-expand about a longitudinal axis from a first configuration to a second configuration having a larger transverse dimension than the first configuration;
a permeable fibrous member disposed within and extending across the expandable occluding component, wherein the permeable fibrous member extends across the expandable occluding component as the expandable occluding component radially self-expands about the longitudinal axis, and wherein the permeable fibrous member comprises a plurality of woven or interspersed strands including a first strand formed of a first metallic material and a second strand formed of a second metallic material different from the first metallic material;
an electrical power source;
a first electrical conductor electrically connected between the first strand and the power source; and second electrical conductor electrically connected between the second strand and the electrical power source.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54182104P | 2004-02-02 | 2004-02-02 | |
| US60/541,821 | 2004-02-02 | ||
| PCT/US2005/003310 WO2005074845A1 (en) | 2004-02-02 | 2005-01-31 | Enhancing tissue ingrowth for contraception |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2555011A1 CA2555011A1 (en) | 2005-08-18 |
| CA2555011C true CA2555011C (en) | 2013-03-26 |
Family
ID=34837521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2555011A Expired - Fee Related CA2555011C (en) | 2004-02-02 | 2005-01-31 | Enhancing tissue ingrowth for contraception |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20060009798A1 (en) |
| EP (1) | EP1715826B1 (en) |
| CN (3) | CN101627938B (en) |
| AU (1) | AU2005209871B2 (en) |
| CA (1) | CA2555011C (en) |
| WO (1) | WO2005074845A1 (en) |
Families Citing this family (180)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6471635B1 (en) | 2000-02-10 | 2002-10-29 | Obtech Medical Ag | Anal incontinence disease treatment with controlled wireless energy supply |
| US6464628B1 (en) | 1999-08-12 | 2002-10-15 | Obtech Medical Ag | Mechanical anal incontinence |
| US6482145B1 (en) | 2000-02-14 | 2002-11-19 | Obtech Medical Ag | Hydraulic anal incontinence treatment |
| EP1253877B1 (en) | 2000-02-10 | 2005-05-11 | Potencia Medical AG | Mechanical impotence treatment apparatus |
| AU759363B2 (en) | 2000-02-10 | 2003-04-10 | Implantica Patent Ltd. | Controlled urinary incontinence treatment |
| US20030125768A1 (en) | 2000-02-11 | 2003-07-03 | Forsell Peter | Impotence treatment apparatus with energy transforming means |
| DE60111019T2 (en) | 2000-02-14 | 2006-05-11 | Potencia Medical Ag | PROSTHESIS |
| EP1255514B1 (en) | 2000-02-14 | 2006-04-26 | Potencia Medical AG | Male impotence prosthesis apparatus with wireless energy supply |
| ES2399091T3 (en) | 2001-12-05 | 2013-03-25 | Keystone Heart Ltd. | Endovascular device for entrapment of particulate matter and method of use |
| US7087064B1 (en) | 2002-10-15 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Apparatuses and methods for heart valve repair |
| US7485143B2 (en) | 2002-11-15 | 2009-02-03 | Abbott Cardiovascular Systems Inc. | Apparatuses and methods for heart valve repair |
| US8187324B2 (en) * | 2002-11-15 | 2012-05-29 | Advanced Cardiovascular Systems, Inc. | Telescoping apparatus for delivering and adjusting a medical device in a vessel |
| US7981152B1 (en) | 2004-12-10 | 2011-07-19 | Advanced Cardiovascular Systems, Inc. | Vascular delivery system for accessing and delivering devices into coronary sinus and other vascular sites |
| US7404824B1 (en) | 2002-11-15 | 2008-07-29 | Advanced Cardiovascular Systems, Inc. | Valve aptation assist device |
| US7335213B1 (en) | 2002-11-15 | 2008-02-26 | Abbott Cardiovascular Systems Inc. | Apparatus and methods for heart valve repair |
| US9149602B2 (en) | 2005-04-22 | 2015-10-06 | Advanced Cardiovascular Systems, Inc. | Dual needle delivery system |
| US7998112B2 (en) | 2003-09-30 | 2011-08-16 | Abbott Cardiovascular Systems Inc. | Deflectable catheter assembly and method of making same |
| US20050107867A1 (en) * | 2003-11-17 | 2005-05-19 | Taheri Syde A. | Temporary absorbable venous occlusive stent and superficial vein treatment method |
| CN101627938B (en) * | 2004-02-02 | 2011-12-21 | 孕体有限公司 | Contraceptive with permeable and impermeable components |
| US8747453B2 (en) * | 2008-02-18 | 2014-06-10 | Aga Medical Corporation | Stent/stent graft for reinforcement of vascular abnormalities and associated method |
| US9039724B2 (en) | 2004-03-19 | 2015-05-26 | Aga Medical Corporation | Device for occluding vascular defects |
| US8313505B2 (en) * | 2004-03-19 | 2012-11-20 | Aga Medical Corporation | Device for occluding vascular defects |
| US8398670B2 (en) * | 2004-03-19 | 2013-03-19 | Aga Medical Corporation | Multi-layer braided structures for occluding vascular defects and for occluding fluid flow through portions of the vasculature of the body |
| US8777974B2 (en) * | 2004-03-19 | 2014-07-15 | Aga Medical Corporation | Multi-layer braided structures for occluding vascular defects |
| US8517027B2 (en) * | 2004-09-03 | 2013-08-27 | Boston Scientific Scimed, Inc. | Reversible vessel seal |
| WO2006042114A1 (en) * | 2004-10-06 | 2006-04-20 | Cook, Inc. | Emboli capturing device having a coil and method for capturing emboli |
| US7972354B2 (en) | 2005-01-25 | 2011-07-05 | Tyco Healthcare Group Lp | Method and apparatus for impeding migration of an implanted occlusive structure |
| US8945169B2 (en) | 2005-03-15 | 2015-02-03 | Cook Medical Technologies Llc | Embolic protection device |
| US8221446B2 (en) | 2005-03-15 | 2012-07-17 | Cook Medical Technologies | Embolic protection device |
| US20060259132A1 (en) * | 2005-05-02 | 2006-11-16 | Cook Incorporated | Vascular stent for embolic protection |
| US8187298B2 (en) * | 2005-08-04 | 2012-05-29 | Cook Medical Technologies Llc | Embolic protection device having inflatable frame |
| US8377092B2 (en) * | 2005-09-16 | 2013-02-19 | Cook Medical Technologies Llc | Embolic protection device |
| US8632562B2 (en) * | 2005-10-03 | 2014-01-21 | Cook Medical Technologies Llc | Embolic protection device |
| US20070078479A1 (en) * | 2005-10-04 | 2007-04-05 | Boston Scientific Scimed, Inc. | Self-expanding vaso-occlusive devices with regulated expansion |
| US8182508B2 (en) * | 2005-10-04 | 2012-05-22 | Cook Medical Technologies Llc | Embolic protection device |
| US8252017B2 (en) * | 2005-10-18 | 2012-08-28 | Cook Medical Technologies Llc | Invertible filter for embolic protection |
| US8216269B2 (en) * | 2005-11-02 | 2012-07-10 | Cook Medical Technologies Llc | Embolic protection device having reduced profile |
| US8152831B2 (en) * | 2005-11-17 | 2012-04-10 | Cook Medical Technologies Llc | Foam embolic protection device |
| US20070208213A1 (en) * | 2006-02-03 | 2007-09-06 | Swann Susan E | Method and apparatus for in-vitro fertilization and tubal occlusion |
| US9017361B2 (en) * | 2006-04-20 | 2015-04-28 | Covidien Lp | Occlusive implant and methods for hollow anatomical structure |
| US8062324B2 (en) * | 2006-05-08 | 2011-11-22 | S.M.T. Research And Development Ltd. | Device and method for vascular filter |
| US7975697B2 (en) | 2006-05-11 | 2011-07-12 | Conceptus, Inc. | Methods and apparatus for occluding reproductive tracts to effect contraception |
| US20080071307A1 (en) | 2006-09-19 | 2008-03-20 | Cook Incorporated | Apparatus and methods for in situ embolic protection |
| US8840625B2 (en) * | 2006-10-18 | 2014-09-23 | Hologic, Inc. | Systems for performing gynecological procedures with closed visualization lumen |
| US8025656B2 (en) * | 2006-11-07 | 2011-09-27 | Hologic, Inc. | Methods, systems and devices for performing gynecological procedures |
| US20080146872A1 (en) * | 2006-11-07 | 2008-06-19 | Gruber William H | Mechanical distension systems for performing a medical procedure in a remote space |
| US8784439B1 (en) * | 2006-11-28 | 2014-07-22 | Stephen V. Ward | Percutaneous medical procedures and devices for closing vessels using mechanical closures |
| US9901434B2 (en) | 2007-02-27 | 2018-02-27 | Cook Medical Technologies Llc | Embolic protection device including a Z-stent waist band |
| US8574253B2 (en) * | 2007-04-06 | 2013-11-05 | Hologic, Inc. | Method, system and device for tissue removal |
| US9259233B2 (en) | 2007-04-06 | 2016-02-16 | Hologic, Inc. | Method and device for distending a gynecological cavity |
| US9095366B2 (en) | 2007-04-06 | 2015-08-04 | Hologic, Inc. | Tissue cutter with differential hardness |
| US20090270898A1 (en) | 2007-04-06 | 2009-10-29 | Interlace Medical, Inc. | Tissue removal device with high reciprocation rate |
| US8983609B2 (en) * | 2007-05-30 | 2015-03-17 | The Cleveland Clinic Foundation | Apparatus and method for treating pulmonary conditions |
| US8133268B2 (en) * | 2007-05-30 | 2012-03-13 | Cordis Corporation | Stent/fiber structural combinations |
| US20110022149A1 (en) * | 2007-06-04 | 2011-01-27 | Cox Brian J | Methods and devices for treatment of vascular defects |
| US8328840B2 (en) | 2007-07-09 | 2012-12-11 | Artventive Medical Group, Inc. | Methods and apparatus for rapid endovascular vessel occlusion and blood flow interruption |
| US20090030500A1 (en) * | 2007-07-27 | 2009-01-29 | Jan Weber | Iron Ion Releasing Endoprostheses |
| US8100129B2 (en) | 2007-08-28 | 2012-01-24 | Conceptus, Inc. | Methods and devices for occluding an ovarian pathway |
| US20090062839A1 (en) * | 2007-08-31 | 2009-03-05 | Cook Incorporated | Barbed stent vascular occlusion device |
| US8292907B2 (en) * | 2007-08-31 | 2012-10-23 | Cook Medical Technologies Llc | Balloon assisted occlusion device |
| US8052745B2 (en) * | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
| US8252018B2 (en) * | 2007-09-14 | 2012-08-28 | Cook Medical Technologies Llc | Helical embolic protection device |
| US8419748B2 (en) * | 2007-09-14 | 2013-04-16 | Cook Medical Technologies Llc | Helical thrombus removal device |
| US9138307B2 (en) * | 2007-09-14 | 2015-09-22 | Cook Medical Technologies Llc | Expandable device for treatment of a stricture in a body vessel |
| US8696543B2 (en) | 2007-10-11 | 2014-04-15 | Kirk Promotion Ltd. | Method for controlling flow of intestinal contents in a patient's intestines |
| US9949871B2 (en) * | 2007-10-11 | 2018-04-24 | Peter Forsell | Method for controlling flow of eggs in a uterine tube |
| EP2211768B1 (en) | 2007-10-11 | 2021-03-24 | Implantica Patent Ltd. | Apparatus for controlling flow in a bodily organ |
| US10195325B2 (en) * | 2007-10-11 | 2019-02-05 | Peter Forsell | Method for controlling flow of sperms in a uterine tube |
| US8992409B2 (en) | 2007-10-11 | 2015-03-31 | Peter Forsell | Method for controlling flow in a bodily organ |
| EP3871623A1 (en) * | 2007-10-11 | 2021-09-01 | Implantica Patent Ltd | Device and method for embryo control |
| US8795153B2 (en) | 2007-10-11 | 2014-08-05 | Peter Forsell | Method for treating female sexual dysfunction |
| US20090099591A1 (en) * | 2007-10-15 | 2009-04-16 | Boston Scientific Scimed, Inc. | Coil Anchor Systems and Methods of Use |
| WO2009052432A2 (en) | 2007-10-19 | 2009-04-23 | Coherex Medical, Inc. | Medical device for modification of left atrial appendange and related systems and methods |
| US8114116B2 (en) * | 2008-01-18 | 2012-02-14 | Cook Medical Technologies Llc | Introduction catheter set for a self-expandable implant |
| EP2244662B1 (en) * | 2008-01-28 | 2021-09-29 | Implantica Patent Ltd. | Blood clot removal device and system |
| WO2009096861A1 (en) | 2008-01-29 | 2009-08-06 | Milux Holding Sa | Methods and instruments for treating obesity and gastroesophageal reflux disease |
| US20100256661A1 (en) * | 2009-04-06 | 2010-10-07 | Zeev Brandeis | Apparatus and method for enabling perforating vein ablation |
| CN106974691A (en) | 2008-05-02 | 2017-07-25 | 斯昆特医疗公司 | Thread device for treating vascular defects |
| EP2299951B1 (en) * | 2008-05-16 | 2012-03-07 | Conceptus, Inc. | Occlusion device and system for occluding a reproductive body lumen |
| US9402707B2 (en) | 2008-07-22 | 2016-08-02 | Neuravi Limited | Clot capture systems and associated methods |
| WO2010016923A1 (en) * | 2008-08-06 | 2010-02-11 | Boston Scientific Scimed, Inc. | Vaso-occlusive devices with textured surfaces |
| US8322341B2 (en) * | 2008-09-09 | 2012-12-04 | Conceptus, Inc. | System and method for occluding a reproductive body lumen |
| WO2010042058A1 (en) | 2008-10-10 | 2010-04-15 | Milux Holding S.A. | An improved artificial valve |
| US8874215B2 (en) | 2008-10-10 | 2014-10-28 | Peter Forsell | System, an apparatus, and a method for treating a sexual dysfunctional female patient |
| EP4282462A3 (en) | 2008-10-10 | 2024-02-21 | MedicalTree Patent Ltd. | Heart help device, system, and method |
| WO2010042019A1 (en) | 2008-10-10 | 2010-04-15 | Milux Holding Sa | Heart help device, system, and method |
| EP2349078A4 (en) | 2008-10-10 | 2018-02-07 | Kirk Promotion LTD. | Fastening means for implantable medcial control assembly |
| ES2962384T3 (en) | 2008-10-10 | 2024-03-18 | Implantica Patent Ltd | Device for the treatment of female sexual dysfunction |
| US9427304B2 (en) * | 2008-10-27 | 2016-08-30 | St. Jude Medical, Cardiology Division, Inc. | Multi-layer device with gap for treating a target site and associated method |
| US8356600B2 (en) * | 2008-11-11 | 2013-01-22 | Conceptus, Inc. | Occlusion implant |
| US8728112B2 (en) * | 2008-11-26 | 2014-05-20 | Cook Medical Technologies Llc | Vascular occlusion device |
| US9320525B2 (en) * | 2008-12-03 | 2016-04-26 | Boston Scientific Scimed, Inc. | Occlusion stent |
| WO2010071856A1 (en) | 2008-12-19 | 2010-06-24 | Tyco Healthcare Group, L.P. | Method and apparatus for storage and/or introduction of implant for hollow anatomical structure |
| US8388644B2 (en) * | 2008-12-29 | 2013-03-05 | Cook Medical Technologies Llc | Embolic protection device and method of use |
| WO2010081033A1 (en) | 2009-01-08 | 2010-07-15 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
| US20100211094A1 (en) * | 2009-02-18 | 2010-08-19 | Cook Incorporated | Umbrella distal embolic protection device |
| US8241298B2 (en) * | 2009-03-27 | 2012-08-14 | Depuy Mitek, Inc. | Methods and devices for delivering and affixing tissue scaffolds |
| US8308814B2 (en) | 2009-03-27 | 2012-11-13 | Depuy Mitek, Inc. | Methods and devices for preparing and implanting tissue scaffolds |
| US20100274277A1 (en) * | 2009-04-27 | 2010-10-28 | Cook Incorporated | Embolic protection device with maximized flow-through |
| US8701670B2 (en) * | 2009-04-29 | 2014-04-22 | Bayer Essure Inc. | Trackable occlusion device and catheter system |
| US11903602B2 (en) | 2009-04-29 | 2024-02-20 | Hologic, Inc. | Uterine fibroid tissue removal device |
| US9351716B2 (en) | 2009-06-17 | 2016-05-31 | Coherex Medical, Inc. | Medical device and delivery system for modification of left atrial appendage and methods thereof |
| US9649115B2 (en) | 2009-06-17 | 2017-05-16 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
| US10064628B2 (en) | 2009-06-17 | 2018-09-04 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
| US9693781B2 (en) | 2009-06-17 | 2017-07-04 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
| US9883864B2 (en) * | 2009-06-17 | 2018-02-06 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
| US10631969B2 (en) | 2009-06-17 | 2020-04-28 | Coherex Medical, Inc. | Medical device for modification of left atrial appendage and related systems and methods |
| US9949812B2 (en) | 2009-07-17 | 2018-04-24 | Peter Forsell | Vaginal operation method for the treatment of anal incontinence in women |
| US10952836B2 (en) | 2009-07-17 | 2021-03-23 | Peter Forsell | Vaginal operation method for the treatment of urinary incontinence in women |
| US20110061659A1 (en) * | 2009-09-17 | 2011-03-17 | Julian Cruzada | Minimally invasive delivery devices and methods |
| JP2013508079A (en) * | 2009-10-19 | 2013-03-07 | クック メディカル テクノロジーズ エルエルシー | Endoscopic system with a balloon at the tip, having a reversible sleeve |
| US20110152993A1 (en) * | 2009-11-05 | 2011-06-23 | Sequent Medical Inc. | Multiple layer filamentary devices or treatment of vascular defects |
| US9457171B2 (en) | 2009-12-02 | 2016-10-04 | Renovorx, Inc. | Devices, methods and kits for delivery of therapeutic materials to a target artery |
| US10512761B2 (en) | 2009-12-02 | 2019-12-24 | Renovorx, Inc. | Methods for delivery of therapeutic materials to treat pancreatic cancer |
| WO2012002944A1 (en) | 2010-06-29 | 2012-01-05 | Artventive Medical Group, Inc. | Reducing flow through a tubular structure |
| CN103179920B (en) * | 2010-08-24 | 2015-11-25 | 爱德华兹生命科学公司 | There is the flexible valve forming ring selecting control point |
| JP2012090949A (en) * | 2010-09-27 | 2012-05-17 | Terumo Corp | Guide wire for endoscope |
| EP2621549B1 (en) | 2010-09-28 | 2015-10-21 | Cook Biotech Incorporated | Device for treating fistulae and other bodily openings and passageways |
| US9149277B2 (en) | 2010-10-18 | 2015-10-06 | Artventive Medical Group, Inc. | Expandable device delivery |
| EP2629684B1 (en) | 2010-10-22 | 2018-07-25 | Neuravi Limited | Clot engagement and removal system |
| US9301769B2 (en) | 2011-03-09 | 2016-04-05 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
| US11259824B2 (en) | 2011-03-09 | 2022-03-01 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
| JP2014522263A (en) * | 2011-05-11 | 2014-09-04 | マイクロベンション インコーポレイテッド | Device for occluding a lumen |
| US9504474B2 (en) | 2011-05-23 | 2016-11-29 | Stryker Corporation | Vaso-occlusive devices with in-situ stiffening |
| US20120330342A1 (en) * | 2011-06-27 | 2012-12-27 | Jones Donald K | Systems and devices for intralumenal implantation |
| EP2755574A1 (en) * | 2011-09-13 | 2014-07-23 | Stryker Corporation | Vaso-occlusive device |
| CA2852266C (en) | 2011-10-18 | 2019-11-26 | William E. Cohn | Method and apparatus for treating a patient by intentionally occluding a blood vessel, including method and apparatus for inducing weight loss in a patient by intentionally occluding the celiac artery |
| US9011481B2 (en) | 2012-12-30 | 2015-04-21 | Cook Medical Technologies Llc | Vascular occlusion device having a jelly fish |
| US9095344B2 (en) | 2013-02-05 | 2015-08-04 | Artventive Medical Group, Inc. | Methods and apparatuses for blood vessel occlusion |
| US8984733B2 (en) | 2013-02-05 | 2015-03-24 | Artventive Medical Group, Inc. | Bodily lumen occlusion |
| ES2960917T3 (en) | 2013-03-14 | 2024-03-07 | Neuravi Ltd | Clot retrieval device to remove occlusive clots from a blood vessel |
| US9433429B2 (en) | 2013-03-14 | 2016-09-06 | Neuravi Limited | Clot retrieval devices |
| WO2014140092A2 (en) | 2013-03-14 | 2014-09-18 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
| WO2014197362A1 (en) | 2013-06-03 | 2014-12-11 | Ramtin Agah | Devices, methods and kits for delivery of therapeutic materials to a pancreas |
| US9737306B2 (en) | 2013-06-14 | 2017-08-22 | Artventive Medical Group, Inc. | Implantable luminal devices |
| US10149968B2 (en) | 2013-06-14 | 2018-12-11 | Artventive Medical Group, Inc. | Catheter-assisted tumor treatment |
| US9737308B2 (en) | 2013-06-14 | 2017-08-22 | Artventive Medical Group, Inc. | Catheter-assisted tumor treatment |
| US9636116B2 (en) | 2013-06-14 | 2017-05-02 | Artventive Medical Group, Inc. | Implantable luminal devices |
| US9078658B2 (en) | 2013-08-16 | 2015-07-14 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
| US9955976B2 (en) | 2013-08-16 | 2018-05-01 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
| CN105722474B (en) | 2013-11-13 | 2018-09-21 | 柯惠有限合伙公司 | The attachment of assist devices and thrombus in a manner of primary battery |
| US9629635B2 (en) | 2014-04-14 | 2017-04-25 | Sequent Medical, Inc. | Devices for therapeutic vascular procedures |
| US10363043B2 (en) | 2014-05-01 | 2019-07-30 | Artventive Medical Group, Inc. | Treatment of incompetent vessels |
| WO2016039979A2 (en) * | 2014-09-08 | 2016-03-17 | Stryker Corporation | Vaso-occlusive devices with in-situ stiffening |
| WO2016086051A1 (en) | 2014-11-24 | 2016-06-02 | Cirrus Technologies Kft | Systems and methods for permanent female contraception |
| US10617435B2 (en) | 2014-11-26 | 2020-04-14 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
| US11253278B2 (en) | 2014-11-26 | 2022-02-22 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
| EP3223723B1 (en) | 2014-11-26 | 2020-01-08 | Neuravi Limited | A clot retrieval device for removing occlusive clot from a blood vessel |
| US10265076B2 (en) * | 2015-03-16 | 2019-04-23 | Steven Clark Block | Vascular occluding bridged self-expanding metal stent (VOBSEMS) |
| US10265515B2 (en) * | 2015-03-27 | 2019-04-23 | Covidien Lp | Galvanically assisted aneurysm treatment |
| US10813644B2 (en) | 2016-04-01 | 2020-10-27 | Artventive Medical Group, Inc. | Occlusive implant and delivery system |
| EP3912569A1 (en) * | 2016-06-10 | 2021-11-24 | Terumo Corporation | Vessel occluder |
| MX2019002565A (en) | 2016-09-06 | 2019-09-18 | Neuravi Ltd | A clot retrieval device for removing occlusive clot from a blood vessel. |
| US10695543B2 (en) | 2017-05-18 | 2020-06-30 | Renovorx, Inc. | Methods for treating cancerous tumors |
| US11052224B2 (en) | 2017-05-18 | 2021-07-06 | Renovorx, Inc. | Methods for treating cancerous tumors |
| US20220104839A1 (en) | 2017-10-16 | 2022-04-07 | Retriever Medical, Inc. | Clot Removal Methods and Devices with Multiple Independently Controllable Elements |
| US10172634B1 (en) | 2017-10-16 | 2019-01-08 | Michael Bruce Horowitz | Catheter based retrieval device with proximal body having axial freedom of movement |
| US20220104840A1 (en) | 2017-10-16 | 2022-04-07 | Retriever Medical, Inc. | Clot Removal Methods and Devices with Multiple Independently Controllable Elements |
| WO2019178579A1 (en) * | 2018-03-16 | 2019-09-19 | Boston Scientific Scimed, Inc. | Devices for vein closure |
| US10842498B2 (en) | 2018-09-13 | 2020-11-24 | Neuravi Limited | Systems and methods of restoring perfusion to a vessel |
| US11406416B2 (en) | 2018-10-02 | 2022-08-09 | Neuravi Limited | Joint assembly for vasculature obstruction capture device |
| US11439401B2 (en) * | 2018-11-16 | 2022-09-13 | Microvention, Inc. | Embolic coil |
| FI130702B1 (en) * | 2018-12-18 | 2024-01-26 | Miikka Frant | A device applicable to insertion into a vein of a human patient |
| EP3908209A4 (en) | 2019-03-15 | 2022-10-19 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
| WO2020190630A1 (en) | 2019-03-15 | 2020-09-24 | Sequent Medical, Inc. | Filamentary devices having a flexible joint for treatment of vascular defects |
| US11317921B2 (en) | 2019-03-15 | 2022-05-03 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
| US11369355B2 (en) | 2019-06-17 | 2022-06-28 | Coherex Medical, Inc. | Medical device and system for occluding a tissue opening and method thereof |
| US11504132B2 (en) | 2019-07-25 | 2022-11-22 | Clearstream Technologies Limited | Embolisation device for promoting blood clot formation and a method of retrieving the same from a bodily lumen |
| US11712231B2 (en) | 2019-10-29 | 2023-08-01 | Neuravi Limited | Proximal locking assembly design for dual stent mechanical thrombectomy device |
| US11517340B2 (en) | 2019-12-03 | 2022-12-06 | Neuravi Limited | Stentriever devices for removing an occlusive clot from a vessel and methods thereof |
| US11730501B2 (en) | 2020-04-17 | 2023-08-22 | Neuravi Limited | Floating clot retrieval device for removing clots from a blood vessel |
| US11717308B2 (en) | 2020-04-17 | 2023-08-08 | Neuravi Limited | Clot retrieval device for removing heterogeneous clots from a blood vessel |
| US11871946B2 (en) | 2020-04-17 | 2024-01-16 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
| US11737771B2 (en) | 2020-06-18 | 2023-08-29 | Neuravi Limited | Dual channel thrombectomy device |
| US11937836B2 (en) | 2020-06-22 | 2024-03-26 | Neuravi Limited | Clot retrieval system with expandable clot engaging framework |
| US11439418B2 (en) | 2020-06-23 | 2022-09-13 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
| US11395669B2 (en) | 2020-06-23 | 2022-07-26 | Neuravi Limited | Clot retrieval device with flexible collapsible frame |
| US11864781B2 (en) | 2020-09-23 | 2024-01-09 | Neuravi Limited | Rotating frame thrombectomy device |
| US11812969B2 (en) | 2020-12-03 | 2023-11-14 | Coherex Medical, Inc. | Medical device and system for occluding a tissue opening and method thereof |
| US11937837B2 (en) | 2020-12-29 | 2024-03-26 | Neuravi Limited | Fibrin rich / soft clot mechanical thrombectomy device |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US452764A (en) * | 1891-05-19 | Frederick salathe | ||
| US3334629A (en) * | 1964-11-09 | 1967-08-08 | Bertram D Cohn | Occlusive device for inferior vena cava |
| US3655996A (en) * | 1969-03-13 | 1972-04-11 | Iwatsu Electric Co Ltd | Protective circuit for input circuit of junction type field effect transistor |
| US3834394A (en) * | 1969-11-21 | 1974-09-10 | R Sessions | Occlusion device and method and apparatus for inserting the same |
| US3687129A (en) * | 1970-10-02 | 1972-08-29 | Abcor Inc | Contraceptive device and method of employing same |
| US3865108A (en) * | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US3815678A (en) * | 1971-09-07 | 1974-06-11 | Allied Chem | Hydrocarbon sweep process |
| US3868956A (en) * | 1972-06-05 | 1975-03-04 | Ralph J Alfidi | Vessel implantable appliance and method of implanting it |
| US3815578A (en) * | 1973-05-11 | 1974-06-11 | Investors In Ventures Inc | Method of inserting an implant into a portion of a tubular organ whose mucous lining has been partially removed |
| US3995108A (en) * | 1975-05-21 | 1976-11-30 | Ampex Corporation | Television aperture correction system having gateable coring means for noise cancellation |
| US4052754A (en) * | 1975-08-14 | 1977-10-11 | Homsy Charles A | Implantable structure |
| US3991760A (en) * | 1975-12-02 | 1976-11-16 | The Procter & Gamble Company | Vaginal medicament dispensing means |
| US4185618A (en) * | 1976-01-05 | 1980-01-29 | Population Research, Inc. | Promotion of fibrous tissue growth in fallopian tubes for female sterilization |
| US4140126A (en) * | 1977-02-18 | 1979-02-20 | Choudhury M Hasan | Method for performing aneurysm repair |
| US4186618A (en) * | 1977-08-05 | 1980-02-05 | Eaton Corporation | Transmission input decelerating and reversing mechanism |
| US4246896A (en) * | 1978-10-30 | 1981-01-27 | Dynatech Corp. | Intracervical cuff (ICC) for contraception and prevention of venereal disease and applicator therefor |
| US4248896A (en) * | 1979-03-01 | 1981-02-03 | Wallace Leland C | Process for baking bread |
| US4279252A (en) * | 1979-08-24 | 1981-07-21 | Martin Michael T | X-ray scaling catheter |
| JPS5845379B2 (en) * | 1979-11-09 | 1983-10-08 | アイシン精機株式会社 | Automotive brake booster |
| US4311146A (en) * | 1980-05-08 | 1982-01-19 | Sorenson Research Co., Inc. | Detachable balloon catheter apparatus and method |
| US4657000A (en) * | 1981-07-23 | 1987-04-14 | Dynasplints Systems, Inc. | Adjustable splint and securing means therefor |
| FR2522959A1 (en) * | 1982-03-15 | 1983-09-16 | Hamou Jacques | Tubular pessary for reversible pregnancy protection - has soft central tubular section with proximal and distal loop of fibrous material |
| US4441495A (en) * | 1982-08-16 | 1984-04-10 | Becton, Dickinson And Company | Detachable balloon catheter device and method of use |
| US4638803A (en) * | 1982-09-30 | 1987-01-27 | Rand Robert W | Medical apparatus for inducing scar tissue formation in a body |
| US4503569A (en) * | 1983-03-03 | 1985-03-12 | Dotter Charles T | Transluminally placed expandable graft prosthesis |
| US5190546A (en) * | 1983-10-14 | 1993-03-02 | Raychem Corporation | Medical devices incorporating SIM alloy elements |
| US5275622A (en) * | 1983-12-09 | 1994-01-04 | Harrison Medical Technologies, Inc. | Endovascular grafting apparatus, system and method and devices for use therewith |
| US5104399A (en) * | 1986-12-10 | 1992-04-14 | Endovascular Technologies, Inc. | Artificial graft and implantation method |
| US4787899A (en) * | 1983-12-09 | 1988-11-29 | Lazarus Harrison M | Intraluminal graft device, system and method |
| US4562596A (en) * | 1984-04-25 | 1986-01-07 | Elliot Kornberg | Aortic graft, device and method for performing an intraluminal abdominal aortic aneurysm repair |
| US4606336A (en) * | 1984-11-23 | 1986-08-19 | Zeluff James W | Method and apparatus for non-surgically sterilizing female reproductive organs |
| FR2573646B1 (en) * | 1984-11-29 | 1988-11-25 | Celsa Composants Electr Sa | PERFECTED FILTER, PARTICULARLY FOR THE RETENTION OF BLOOD CLOTS |
| US4705517A (en) * | 1985-09-03 | 1987-11-10 | Becton, Dickinson And Company | Percutaneously deliverable intravascular occlusion prosthesis |
| US4700701A (en) * | 1985-10-23 | 1987-10-20 | Montaldi David H | Sterilization method and apparatus |
| US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US4964850A (en) * | 1986-05-07 | 1990-10-23 | Vincent Bouton | Method for treating trans-nasal sinus afflictions using a double t-shaped trans-nasal aerator |
| US4869268A (en) * | 1987-05-14 | 1989-09-26 | Inbae Yoon | Multi-functional instruments and stretchable ligating and occluding devices |
| US4969458A (en) * | 1987-07-06 | 1990-11-13 | Medtronic, Inc. | Intracoronary stent and method of simultaneous angioplasty and stent implant |
| US4787699A (en) * | 1987-09-01 | 1988-11-29 | Hughes Aircraft Company | Fiber optic terminus |
| EP0320887B1 (en) * | 1987-12-14 | 1993-08-11 | Ichikoh Industries Limited | Method for forming fresnel-type prism lens |
| US4857000A (en) * | 1988-02-16 | 1989-08-15 | Tektronix, Inc. | Circuit board ejector/guide |
| IT1227063B (en) * | 1988-09-14 | 1991-03-14 | Francesco Pianetti | BIMETALLIC SPIRAL INTRAUTERINE DEVICE. |
| US4994069A (en) * | 1988-11-02 | 1991-02-19 | Target Therapeutics | Vaso-occlusion coil and method |
| FR2641692A1 (en) * | 1989-01-17 | 1990-07-20 | Nippon Zeon Co | Plug for closing an opening for a medical application, and device for the closure plug making use thereof |
| CH678393A5 (en) * | 1989-01-26 | 1991-09-13 | Ulrich Prof Dr Med Sigwart | |
| US5163958A (en) * | 1989-02-02 | 1992-11-17 | Cordis Corporation | Carbon coated tubular endoprosthesis |
| HU200905B (en) * | 1989-02-07 | 1990-09-28 | Radelkis Electrokemiai | Electrochemical contraceptive device |
| US5116318A (en) * | 1989-06-06 | 1992-05-26 | Cordis Corporation | Dilatation balloon within an elastic sleeve |
| US5919202A (en) * | 1989-12-05 | 1999-07-06 | Yoon; Inbae | Surgical instrument with jaws and movable internal needle and method for use thereof |
| US5354295A (en) * | 1990-03-13 | 1994-10-11 | Target Therapeutics, Inc. | In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
| US5197878A (en) * | 1990-10-23 | 1993-03-30 | Thomas A. Lukase | Clamp for removing a dental prosthetic |
| US5108420A (en) * | 1991-02-01 | 1992-04-28 | Temple University | Aperture occlusion device |
| CA2065634C (en) * | 1991-04-11 | 1997-06-03 | Alec A. Piplani | Endovascular graft having bifurcation and apparatus and method for deploying the same |
| US5267945A (en) * | 1991-04-24 | 1993-12-07 | David Doctor | Finger splint for treating pip joint injuries |
| US5197978B1 (en) * | 1991-04-26 | 1996-05-28 | Advanced Coronary Tech | Removable heat-recoverable tissue supporting device |
| US5147370A (en) * | 1991-06-12 | 1992-09-15 | Mcnamara Thomas O | Nitinol stent for hollow body conduits |
| US5474089A (en) * | 1991-06-26 | 1995-12-12 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method and device for reversible sterilization |
| US5458713A (en) * | 1991-09-25 | 1995-10-17 | Gao Gesellschaft Fuer Automation Und Organisation Mbh | Multilayer data carrier and a method for producing it |
| US5226911A (en) * | 1991-10-02 | 1993-07-13 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
| US5456713A (en) * | 1991-10-25 | 1995-10-10 | Cook Incorporated | Expandable transluminal graft prosthesis for repairs of aneurysm and method for implanting |
| US5167614A (en) * | 1991-10-29 | 1992-12-01 | Medical Engineering Corporation | Prostatic stent |
| US5176692A (en) * | 1991-12-09 | 1993-01-05 | Wilk Peter J | Method and surgical instrument for repairing hernia |
| US5626605A (en) * | 1991-12-30 | 1997-05-06 | Scimed Life Systems, Inc. | Thrombosis filter |
| US5176240A (en) * | 1992-03-05 | 1993-01-05 | Overton Corporation | Indexing machine with roller cam drive |
| US5303719A (en) * | 1992-08-14 | 1994-04-19 | Wilk Peter J | Surgical method and associated instrument assembly |
| US5382261A (en) * | 1992-09-01 | 1995-01-17 | Expandable Grafts Partnership | Method and apparatus for occluding vessels |
| US5382259A (en) * | 1992-10-26 | 1995-01-17 | Target Therapeutics, Inc. | Vasoocclusion coil with attached tubular woven or braided fibrous covering |
| US5423849A (en) * | 1993-01-15 | 1995-06-13 | Target Therapeutics, Inc. | Vasoocclusion device containing radiopaque fibers |
| US5512051A (en) * | 1993-02-16 | 1996-04-30 | Boston Scientific Corporation | Slip-layered catheter balloon |
| US5801600A (en) * | 1993-10-14 | 1998-09-01 | Deltec New Zealand Limited | Variable differential phase shifter providing phase variation of two output signals relative to one input signal |
| US5487377A (en) * | 1993-11-05 | 1996-01-30 | Clinical Innovation Associates, Inc. | Uterine manipulator and manipulator tip assembly |
| JP3185906B2 (en) * | 1993-11-26 | 2001-07-11 | ニプロ株式会社 | Prosthesis for atrial septal defect |
| US5490996A (en) * | 1994-01-11 | 1996-02-13 | Kraft Jacobs Suchard Ag | Process for producing an improved sucrose-free milk chocolate |
| US5405000A (en) * | 1994-02-28 | 1995-04-11 | Hagedon; Bryan D. | Protective suspension package |
| US5499995C1 (en) * | 1994-05-25 | 2002-03-12 | Paul S Teirstein | Body passageway closure apparatus and method of use |
| US5545210A (en) * | 1994-09-22 | 1996-08-13 | Advanced Coronary Technology, Inc. | Method of implanting a permanent shape memory alloy stent |
| US5514176A (en) * | 1995-01-20 | 1996-05-07 | Vance Products Inc. | Pull apart coil stent |
| US5507611A (en) * | 1995-01-24 | 1996-04-16 | Collister; Frank C. | Key bolt fastener |
| US5634936A (en) * | 1995-02-06 | 1997-06-03 | Scimed Life Systems, Inc. | Device for closing a septal defect |
| DE19508805C2 (en) * | 1995-03-06 | 2000-03-30 | Lutz Freitag | Stent for placement in a body tube with a flexible support structure made of at least two wires with different shape memory functions |
| US6143007A (en) * | 1995-04-28 | 2000-11-07 | Target Therapeutics, Inc. | Method for making an occlusive device |
| US6705323B1 (en) * | 1995-06-07 | 2004-03-16 | Conceptus, Inc. | Contraceptive transcervical fallopian tube occlusion devices and methods |
| US6176240B1 (en) * | 1995-06-07 | 2001-01-23 | Conceptus, Inc. | Contraceptive transcervical fallopian tube occlusion devices and their delivery |
| US5766203A (en) * | 1995-07-20 | 1998-06-16 | Intelliwire, Inc. | Sheath with expandable distal extremity and balloon catheters and stents for use therewith and method |
| CN1141158A (en) * | 1995-07-25 | 1997-01-29 | 温学强 | Contraceptive suppository spaced in oviduct |
| US5601600A (en) * | 1995-09-08 | 1997-02-11 | Conceptus, Inc. | Endoluminal coil delivery system having a mechanical release mechanism |
| US6090063A (en) * | 1995-12-01 | 2000-07-18 | C. R. Bard, Inc. | Device, system and method for implantation of filaments and particles in the body |
| US6090083A (en) * | 1996-01-31 | 2000-07-18 | Scimed Life Systems, Inc. | Low profile valve and balloon catheter |
| WO1997027893A1 (en) * | 1996-02-02 | 1997-08-07 | Transvascular, Inc. | Methods and apparatus for blocking flow through blood vessels |
| US6270495B1 (en) * | 1996-02-22 | 2001-08-07 | Radiotherapeutics Corporation | Method and device for enhancing vessel occlusion |
| US5669933A (en) * | 1996-07-17 | 1997-09-23 | Nitinol Medical Technologies, Inc. | Removable embolus blood clot filter |
| US6096052A (en) * | 1998-07-08 | 2000-08-01 | Ovion, Inc. | Occluding device and method of use |
| US7073504B2 (en) * | 1996-12-18 | 2006-07-11 | Ams Research Corporation | Contraceptive system and method of use |
| US6042590A (en) * | 1997-06-16 | 2000-03-28 | Novomedics, Llc | Apparatus and methods for fallopian tube occlusion |
| US5935137A (en) * | 1997-07-18 | 1999-08-10 | Gynecare, Inc. | Tubular fallopian sterilization device |
| US7491232B2 (en) * | 1998-09-18 | 2009-02-17 | Aptus Endosystems, Inc. | Catheter-based fastener implantation apparatus and methods with implantation force resolution |
| US6145506A (en) * | 1998-04-14 | 2000-11-14 | Goll; Dawn M. | Decorative penile wrap |
| US6168633B1 (en) * | 1998-08-10 | 2001-01-02 | Itzhak Shoher | Composite surface composition for an implant structure |
| US6093194A (en) * | 1998-09-14 | 2000-07-25 | Endocare, Inc. | Insertion device for stents and methods for use |
| US6112747A (en) * | 1998-11-06 | 2000-09-05 | Jones; Jesse M. | Method of sterilizing females |
| DE19857103A1 (en) * | 1998-12-10 | 2000-06-15 | Bsh Bosch Siemens Hausgeraete | Household dishwasher |
| US6231589B1 (en) * | 1999-03-22 | 2001-05-15 | Microvena Corporation | Body vessel filter |
| US6034361A (en) * | 1999-04-28 | 2000-03-07 | Hewlett-Packard Company | System for monitoring the progress of a chemical reaction in a microwave-assisted heating system |
| US6267776B1 (en) * | 1999-05-03 | 2001-07-31 | O'connell Paul T. | Vena cava filter and method for treating pulmonary embolism |
| US6526079B1 (en) * | 1999-08-10 | 2003-02-25 | Coretek, Inc. | Single etalon optical wavelength reference device |
| US6709667B1 (en) * | 1999-08-23 | 2004-03-23 | Conceptus, Inc. | Deployment actuation system for intrafallopian contraception |
| AU7066300A (en) * | 1999-08-23 | 2001-03-19 | Conceptus, Inc. | Insertion/deployment catheter system for intrafallopian contraception |
| KR100337308B1 (en) * | 2000-08-21 | 2002-05-17 | 이계안 | Bushing in suspension arm of vehicle |
| US6716238B2 (en) * | 2001-05-10 | 2004-04-06 | Scimed Life Systems, Inc. | Stent with detachable tethers and method of using same |
| US20030066533A1 (en) * | 2001-10-05 | 2003-04-10 | Loy Randall A. | Removable fallopian tube plug and associated methods |
| US6643311B2 (en) * | 2001-10-23 | 2003-11-04 | William F. Krupke | Diode-pumped alkali laser |
| WO2003103476A2 (en) * | 2002-06-05 | 2003-12-18 | Nmt Medical, Inc. | Patent foramen ovale (pfo) closure device with radial and circumferential support |
| CN1731944A (en) * | 2002-10-31 | 2006-02-08 | 康艾尔公司 | Hair treatment system and method |
| US7321682B2 (en) * | 2002-11-12 | 2008-01-22 | Namco Bandai Games, Inc. | Image generation system, image generation method, program, and information storage medium |
| US20040211428A1 (en) * | 2003-02-28 | 2004-10-28 | Sunrise Medical Hhg Inc. | Nasal mask cushion |
| US20040169324A1 (en) * | 2003-02-28 | 2004-09-02 | Bottene Marlon V. | Strut spring seat |
| US20050107867A1 (en) * | 2003-11-17 | 2005-05-19 | Taheri Syde A. | Temporary absorbable venous occlusive stent and superficial vein treatment method |
| CN101627938B (en) * | 2004-02-02 | 2011-12-21 | 孕体有限公司 | Contraceptive with permeable and impermeable components |
-
2005
- 2005-01-31 CN CN2009101490736A patent/CN101627938B/en not_active Expired - Fee Related
- 2005-01-31 US US11/048,221 patent/US20060009798A1/en not_active Abandoned
- 2005-01-31 WO PCT/US2005/003310 patent/WO2005074845A1/en active Application Filing
- 2005-01-31 CN CN2005800097909A patent/CN1937976B/en not_active Expired - Fee Related
- 2005-01-31 EP EP05722687A patent/EP1715826B1/en not_active Expired - Fee Related
- 2005-01-31 CA CA2555011A patent/CA2555011C/en not_active Expired - Fee Related
- 2005-01-31 AU AU2005209871A patent/AU2005209871B2/en not_active Ceased
- 2005-01-31 CN CNB2005800082320A patent/CN100518693C/en not_active Expired - Fee Related
- 2005-02-01 US US11/048,237 patent/US20050209633A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1929798A (en) | 2007-03-14 |
| CA2555011A1 (en) | 2005-08-18 |
| US20050209633A1 (en) | 2005-09-22 |
| CN101627938B (en) | 2011-12-21 |
| WO2005074845A1 (en) | 2005-08-18 |
| CN1937976A (en) | 2007-03-28 |
| EP1715826B1 (en) | 2013-03-06 |
| EP1715826A1 (en) | 2006-11-02 |
| AU2005209871B2 (en) | 2010-06-17 |
| CN1937976B (en) | 2011-12-07 |
| CN100518693C (en) | 2009-07-29 |
| US20060009798A1 (en) | 2006-01-12 |
| AU2005209871A1 (en) | 2005-08-18 |
| CN101627938A (en) | 2010-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2555011C (en) | Enhancing tissue ingrowth for contraception | |
| US6096052A (en) | Occluding device and method of use | |
| US6432116B1 (en) | Occluding device and method of use | |
| US20050217680A1 (en) | Occluding device and method of use | |
| AU2008243176B2 (en) | Aneurysm treatment device | |
| US8100129B2 (en) | Methods and devices for occluding an ovarian pathway | |
| AU2008229892B2 (en) | Occluding device and method of use | |
| US20140213971A1 (en) | Nerve impingement systems including an intravascular prosthesis and an extravascular prosthesis and associated systems and methods | |
| WO2006028679A1 (en) | Reversible vessel seal | |
| US8875712B2 (en) | System and method for occluding a reproductive body lumen | |
| US9320525B2 (en) | Occlusion stent | |
| JP2018501070A (en) | Biological foundation expandable occlusion device | |
| US20220039804A1 (en) | Flow-diverting implant and delivery method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180131 |