CA2554696A1 - Androgen receptor modulators - Google Patents

Androgen receptor modulators Download PDF

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Publication number
CA2554696A1
CA2554696A1 CA002554696A CA2554696A CA2554696A1 CA 2554696 A1 CA2554696 A1 CA 2554696A1 CA 002554696 A CA002554696 A CA 002554696A CA 2554696 A CA2554696 A CA 2554696A CA 2554696 A1 CA2554696 A1 CA 2554696A1
Authority
CA
Canada
Prior art keywords
androgen receptor
receptor modulators
modulators
androgen
benzonitriles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002554696A
Other languages
French (fr)
Other versions
CA2554696C (en
Inventor
Lain-Yen Hu
Huangshu Lei
Daniel Yunlong Du
Bruce Allen Lefker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner-Lambert Company Llc
Lain-Yen Hu
Huangshu Lei
Daniel Yunlong Du
Bruce Allen Lefker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company Llc, Lain-Yen Hu, Huangshu Lei, Daniel Yunlong Du, Bruce Allen Lefker filed Critical Warner-Lambert Company Llc
Publication of CA2554696A1 publication Critical patent/CA2554696A1/en
Application granted granted Critical
Publication of CA2554696C publication Critical patent/CA2554696C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Abstract

The present invention is directed to a new class of 4-oxo-benzonitriles, their use as androgen modulators, and to their use in the treatment of alopecia.
CA002554696A 2004-02-13 2005-01-31 Androgen receptor modulators Expired - Fee Related CA2554696C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US54473804P 2004-02-13 2004-02-13
US60/544,738 2004-02-13
US60564704P 2004-08-30 2004-08-30
US60/605,647 2004-08-30
PCT/IB2005/000229 WO2005080320A1 (en) 2004-02-13 2005-01-31 Androgen receptor modulators

Publications (2)

Publication Number Publication Date
CA2554696A1 true CA2554696A1 (en) 2005-09-01
CA2554696C CA2554696C (en) 2009-06-30

Family

ID=34890476

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002554696A Expired - Fee Related CA2554696C (en) 2004-02-13 2005-01-31 Androgen receptor modulators

Country Status (20)

Country Link
US (1) US7576128B2 (en)
EP (1) EP1716110A1 (en)
JP (1) JP3997255B2 (en)
KR (1) KR100783255B1 (en)
AP (1) AP2006003700A0 (en)
AR (1) AR047606A1 (en)
AU (1) AU2005214167B2 (en)
BR (1) BRPI0507670A (en)
CA (1) CA2554696C (en)
CR (1) CR8555A (en)
EA (1) EA009902B1 (en)
EC (1) ECSP066761A (en)
IL (1) IL176935A0 (en)
MA (1) MA28361A1 (en)
NO (1) NO20064053L (en)
PA (1) PA8623501A1 (en)
PE (1) PE20051168A1 (en)
TW (1) TW200534842A (en)
UY (1) UY28746A1 (en)
WO (1) WO2005080320A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005100305A1 (en) 2004-04-13 2005-10-27 Warner-Lambert Company Llc Androgen modulators
EP1740533A1 (en) 2004-04-22 2007-01-10 Warner-Lambert Company LLC Androgen modulators
MXPA06015169A (en) * 2004-07-08 2007-08-21 Warner Lambert Co Androgen modulators.
BRPI0514469A (en) * 2004-08-18 2008-06-10 Warner Lambert Co androgen modulators
CN101044131A (en) * 2004-08-31 2007-09-26 沃尼尔·朗伯有限责任公司 Androgen modulators
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
TW200708499A (en) * 2005-06-22 2007-03-01 Warner Lambert Co Process for producing ethers
WO2007007149A1 (en) * 2005-07-12 2007-01-18 Warner-Lambert Company Llc Androgen modulators
US20090170886A1 (en) * 2005-08-08 2009-07-02 Pfizer Inc Androgen modulators
EP3108879A1 (en) * 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation
US20210292335A1 (en) * 2018-08-07 2021-09-23 Emory University Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto

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Also Published As

Publication number Publication date
NO20064053L (en) 2006-11-08
PE20051168A1 (en) 2006-02-18
WO2005080320A1 (en) 2005-09-01
AU2005214167A1 (en) 2005-09-01
BRPI0507670A (en) 2007-07-17
EA200601267A1 (en) 2006-12-29
KR100783255B1 (en) 2007-12-06
US20050182132A1 (en) 2005-08-18
JP2007522199A (en) 2007-08-09
UY28746A1 (en) 2005-09-30
AR047606A1 (en) 2006-01-25
PA8623501A1 (en) 2005-08-30
AP2006003700A0 (en) 2006-08-31
AU2005214167B2 (en) 2008-08-07
KR20060116223A (en) 2006-11-14
JP3997255B2 (en) 2007-10-24
CA2554696C (en) 2009-06-30
EA009902B1 (en) 2008-04-28
US7576128B2 (en) 2009-08-18
TW200534842A (en) 2005-11-01
ECSP066761A (en) 2006-11-16
CR8555A (en) 2006-10-17
IL176935A0 (en) 2006-12-10
MA28361A1 (en) 2006-12-01
EP1716110A1 (en) 2006-11-02

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