CA2552468A1 - Medicament inhaler - Google Patents

Medicament inhaler Download PDF

Info

Publication number
CA2552468A1
CA2552468A1 CA002552468A CA2552468A CA2552468A1 CA 2552468 A1 CA2552468 A1 CA 2552468A1 CA 002552468 A CA002552468 A CA 002552468A CA 2552468 A CA2552468 A CA 2552468A CA 2552468 A1 CA2552468 A1 CA 2552468A1
Authority
CA
Canada
Prior art keywords
inhaler
doses
medicament
medicament inhaler
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002552468A
Other languages
French (fr)
Other versions
CA2552468C (en
Inventor
Lawrence Keane
David O`Leary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norton Healthcare Ltd
Original Assignee
Norton Healthcare Ltd.
Lawrence Keane
David O`Leary
Norton Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norton Healthcare Ltd., Lawrence Keane, David O`Leary, Norton Healthcare Limited filed Critical Norton Healthcare Ltd.
Publication of CA2552468A1 publication Critical patent/CA2552468A1/en
Application granted granted Critical
Publication of CA2552468C publication Critical patent/CA2552468C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0005Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007Mechanical counters
    • A61M15/0071Mechanical counters having a display or indicator
    • A61M15/0078Mechanical counters having a display or indicator on a strip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0086Inhalation chambers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • A61M15/0093Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • A61M15/0096Hindering inhalation before activation of the dispenser
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06MCOUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00Design features of general application
    • G06M1/04Design features of general application for driving the stage of lowest order
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06MCOUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00Design features of general application
    • G06M1/22Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24Drums; Dials; Pointers
    • G06M1/246Bands; Sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Gyroscopes (AREA)

Abstract

A new and improved inhaler includes an accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses, and a dose counting system indicating the number of doses remaining in the inhaler
CA002552468A 2000-06-23 2001-06-23 Medicament inhaler Expired - Lifetime CA2552468C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21338200P 2000-06-23 2000-06-23
US21366800P 2000-06-23 2000-06-23
US60/213,668 2000-06-23
US60/213,382 2000-06-23
CA002407262A CA2407262C (en) 2000-06-23 2001-06-23 Medicament inhaler

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002407262A Division CA2407262C (en) 2000-06-23 2001-06-23 Medicament inhaler

Publications (2)

Publication Number Publication Date
CA2552468A1 true CA2552468A1 (en) 2002-01-03
CA2552468C CA2552468C (en) 2008-02-19

Family

ID=26908022

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002552468A Expired - Lifetime CA2552468C (en) 2000-06-23 2001-06-23 Medicament inhaler
CA002407262A Expired - Lifetime CA2407262C (en) 2000-06-23 2001-06-23 Medicament inhaler

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002407262A Expired - Lifetime CA2407262C (en) 2000-06-23 2001-06-23 Medicament inhaler

Country Status (16)

Country Link
US (4) US6701917B2 (en)
EP (3) EP2314336B1 (en)
JP (3) JP4015943B2 (en)
KR (3) KR100518721B1 (en)
AT (2) ATE281861T1 (en)
AU (2) AU2001270113B2 (en)
CA (2) CA2552468C (en)
DE (1) DE60107107T2 (en)
DK (2) DK2314336T3 (en)
ES (3) ES2520966T3 (en)
GB (3) GB2365778B (en)
PE (3) PE20020163A1 (en)
PT (3) PT1330280E (en)
TW (3) TWI224514B (en)
UY (3) UY26794A1 (en)
WO (1) WO2002000281A2 (en)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1047467B1 (en) 1998-01-16 2004-06-23 1263152 Ontario Inc. Indicating device for use with a dispensing device
US6082358A (en) 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
TWI224514B (en) * 2000-06-23 2004-12-01 Norton Healthcare Ltd Dose metering system for medicament inhaler
ZA200306564B (en) * 2001-02-26 2004-10-15 Optinose As Nasal devices.
GB0128148D0 (en) 2001-11-23 2002-01-16 Innovata Biomed Ltd Assembly
CA2479751C (en) 2002-03-20 2008-06-03 Trent Poole Inhalation apparatus
US7004164B2 (en) * 2002-03-21 2006-02-28 Trudell Medical International Indicating device for aerosol container
DK1487523T3 (en) * 2002-03-22 2017-08-28 Clinical Designs Ltd FIXING FOR A BOX
EP1658872B2 (en) * 2002-07-31 2019-08-21 CHIESI FARMACEUTICI S.p.A. Powder inhaler
US7322352B2 (en) * 2002-09-21 2008-01-29 Aventis Pharma Limited Inhaler
US6883517B2 (en) * 2002-09-30 2005-04-26 Asaf Halamish Downdraft nebulizer
KR100581385B1 (en) * 2002-10-11 2006-05-22 오츠카 세이야쿠 가부시키가이샤 Powder inhalation device
US7575003B2 (en) * 2002-11-04 2009-08-18 Bang & Olufsen Medicom A/S Device for dispension
GB0226021D0 (en) * 2002-11-07 2002-12-18 Corporate Intellectual Propert A container
GB0226020D0 (en) * 2002-11-07 2002-12-18 Glaxo Group Ltd A holder
US20040177848A1 (en) * 2003-03-12 2004-09-16 Alley Kenneth A. Multi-compartment inhaler
FR2854973B1 (en) * 2003-05-15 2005-08-19 Valois Sas DOS COUNTER FOR FLUID PRODUCT DISPENSER.
EP1488819A1 (en) 2003-06-16 2004-12-22 Rijksuniversiteit te Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
US7600512B2 (en) * 2003-07-14 2009-10-13 Vortran Medical Technology 1, Inc. Inhaler with breath actuated dose counter
US7703454B2 (en) * 2003-07-14 2010-04-27 Vortran Medical Technology Inhaler with breath actuated dose counter
GB0323085D0 (en) * 2003-10-02 2003-11-05 Norton Healthcare Ltd Dry powder inhalation apparatus
US7621273B2 (en) * 2003-10-28 2009-11-24 Trudell Medical International Indicating device with warning dosage indicator
US7100530B2 (en) 2003-12-15 2006-09-05 Trudell Medical International, Inc. Dose indicating device
MXPA06009133A (en) 2004-02-16 2007-01-26 Glaxo Group Ltd Counter for use with a medicament dispenser.
JP4940127B2 (en) * 2004-03-10 2012-05-30 グラクソ グループ リミテッド Dosing device
WO2005102429A1 (en) 2004-04-21 2005-11-03 Innovata Biomed Limited Inhaler
GB0409197D0 (en) * 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
DE202004007115U1 (en) * 2004-05-03 2004-07-08 Altana Pharma Ag Blindungsvorrichtung
ES2385934T3 (en) 2004-08-20 2012-08-03 Mannkind Corporation CATALYSIS OF THE SYNTHESIS OF DICETOPIPERAZINA.
KR101644250B1 (en) 2004-08-23 2016-07-29 맨카인드 코포레이션 Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery
US7543582B2 (en) 2004-09-20 2009-06-09 Trudell Medical International Dose indicating device with display elements attached to container
GB0427028D0 (en) 2004-12-09 2005-01-12 Cambridge Consultants Dry powder inhalers
WO2006062448A1 (en) * 2004-12-10 2006-06-15 Ernst Hörlins Ingenjörsbyrå Ab Dose inhaler with a dose counter
CA2899340A1 (en) 2005-01-20 2006-07-27 Trudell Medical International Dispensing device
GB0507100D0 (en) * 2005-04-08 2005-05-11 Team Holdings Uk Ltd Improvements in or relating to inhalers
TWI442951B (en) 2005-04-14 2014-07-01 Astrazeneca Ab Inhaler counter
US7219664B2 (en) * 2005-04-28 2007-05-22 Kos Life Sciences, Inc. Breath actuated inhaler
JP4500280B2 (en) * 2005-06-08 2010-07-14 日立オートモティブシステムズ株式会社 Powder drug dispenser
GB0518355D0 (en) * 2005-09-08 2005-10-19 Glaxo Group Ltd An inhaler
DK1928423T3 (en) 2005-09-14 2016-02-29 Mannkind Corp A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces
GB0519151D0 (en) 2005-09-20 2005-10-26 Aventis Pharma Ltd Inhaler
US8039431B2 (en) 2006-02-22 2011-10-18 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US8517019B2 (en) * 2006-03-03 2013-08-27 3M Innovative Properties Company Method and apparatus for metered dose dispensing
GB0605150D0 (en) 2006-03-14 2006-04-26 Glaxo Group Ltd Counter For Use With A Medicament Dispenser
US20070295329A1 (en) * 2006-06-13 2007-12-27 Lieberman Eric A Dose indicator
US8141550B2 (en) 2006-08-01 2012-03-27 Trudell Medical International Dispensing device
CA2673553C (en) * 2006-12-22 2014-06-17 Laboratorios Almirall, S.A. Breath actuated metering slide for a powder inhaler
US8225790B2 (en) 2007-01-02 2012-07-24 Astrazeneca Ab Inhaler 624
DE102007056263A1 (en) * 2007-11-22 2009-05-28 Siegfried Generics International Ag Dosing device for inhaling a powdery substance
EP2534957B1 (en) 2007-12-14 2015-05-27 AeroDesigns, Inc Delivering aerosolizable products
GB0800457D0 (en) * 2008-01-11 2008-02-20 Innovata Biomed Ltd Improvements in or relating to inhalers
US8082873B2 (en) * 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
ES2691401T3 (en) * 2008-05-07 2018-11-27 Map Pharmaceuticals Inc. Dose counter and locking mechanism
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
AU2009257311B2 (en) 2008-06-13 2014-12-04 Mannkind Corporation A dry powder inhaler and system for drug delivery
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
TWI532497B (en) 2008-08-11 2016-05-11 曼凱公司 Use of ultrarapid acting insulin
US8596265B2 (en) 2008-10-22 2013-12-03 Trudell Medical International Modular aerosol delivery system
US8381719B1 (en) 2008-12-22 2013-02-26 Trudell Medical International Medicament delivery system with dose indicator and oversleeve actuator
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DE202008017185U1 (en) 2008-12-30 2010-05-12 Siegfried Generics International Ag metering
GB0904040D0 (en) * 2009-03-10 2009-04-22 Euro Celtique Sa Counter
JP5667095B2 (en) 2009-03-11 2015-02-12 マンカインド コーポレイション Apparatus, system and method for measuring inhaler resistance
GB2470550A (en) * 2009-05-19 2010-12-01 Alexander Burnup Adjusting Device Comprising Flexible Member with Indicia .
GB0910537D0 (en) 2009-06-18 2009-07-29 Ivax Pharmaceuticals Ireland Inhaler
CA2764505C (en) 2009-06-12 2018-09-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
WO2011008662A1 (en) * 2009-07-13 2011-01-20 Meadwestvaco Calmar Gmbh Powder delivery devices and methods of using the same
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
GB0919465D0 (en) * 2009-11-06 2009-12-23 Norton Healthcare Ltd Airflow adaptor for a breath-actuated dry powder inhaler
AU2013231209B2 (en) * 2010-05-18 2015-11-12 Ivax Pharmaceuticals Ireland Dose counters for inhalers, inhalers and shafts thereof
ES2544277T3 (en) 2010-05-18 2015-08-28 Ivax Pharmaceuticals Ireland Dose counter for inhalers and inhaler
CN105903107A (en) * 2010-05-18 2016-08-31 艾瓦克斯医药爱尔兰公司 Dose counters for inhalers, inhalers and shafts thereof
RU2571331C1 (en) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Systems and methods for dry powder drug delivery
CN105667994B (en) 2011-04-01 2018-04-06 曼金德公司 Blister package for pharmaceutical kit
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US9202164B2 (en) 2011-09-26 2015-12-01 Trudell Medical International Dose counter and medication delivery device
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
GB201304784D0 (en) * 2013-03-15 2013-05-01 Euro Celtique Sa Dispenser
ES2754388T3 (en) 2013-03-15 2020-04-17 Mannkind Corp Compositions and methods of microcrystalline dicetopiperazine
AR096077A1 (en) * 2013-04-26 2015-12-02 Sanofi Sa MECHANISM FOR A DRUG ADMINISTRATION DEVICE
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
AU355092S (en) * 2013-10-07 2014-04-17 Teva Uk Ltd Respiratory apparatus
USD783807S1 (en) * 2013-10-07 2017-04-11 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783159S1 (en) * 2013-10-07 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
AU355175S (en) * 2013-10-07 2014-04-29 Teva Uk Ltd Respiratory apparatus
AU355166S (en) * 2013-10-07 2014-04-28 Teva Uk Ltd Respiratory apparatus
AU355165S (en) * 2013-10-07 2014-04-28 Teva Uk Ltd Respiratory apparatus
AU355177S (en) * 2013-10-07 2014-04-29 Teva Uk Ltd Respiratory apparatus
USD783151S1 (en) * 2013-10-07 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
PT3054920T (en) * 2013-10-07 2021-03-23 Teva Branded Pharmaceutical Products R&D Inc Dry powder inhaler
USD783149S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
AU355172S (en) * 2013-10-08 2014-04-29 Teva Uk Ltd Respiratory Apparatus
USD783154S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
AU355247S (en) * 2013-10-08 2014-05-02 Teva Branded Pharmaceutical Products R&D Respiratory apparatus
USD782648S1 (en) * 2013-10-08 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
AU355245S (en) * 2013-10-08 2014-05-02 Teva Branded Pharmaceutical Products R&D Respiratory apparatus
AU355168S (en) * 2013-10-08 2014-04-29 Teva Uk Ltd Respiratory apparatus
AU355056S (en) * 2013-10-08 2014-04-16 Teva Uk Ltd Respiratory apparatus
AU355203S (en) * 2013-10-08 2014-05-01 Teva Uk Ltd Respiratory apparatus
USD782653S1 (en) * 2013-10-08 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783147S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory appartus
USD782647S1 (en) * 2013-10-08 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783155S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
AU355164S (en) * 2013-10-08 2014-04-28 Teva Uk Ltd Respiratory apparatus
AU355204S (en) * 2013-10-08 2014-05-02 Teva Uk Ltd Respiratory apparatus
USD783148S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
GB201319265D0 (en) * 2013-10-31 2013-12-18 Norton Waterford Ltd Medicament inhaler
AU356105S (en) * 2013-11-29 2014-06-24 Norton Waterford Ltd Respiratory apparatus
AU356104S (en) * 2013-11-29 2014-06-24 Norton Waterford Ltd Respiratory apparatus
GB201321712D0 (en) * 2013-12-09 2014-01-22 Pharmachemie Bv Dry Powder Inhaler
GB201321717D0 (en) * 2013-12-09 2014-01-22 Pharmachemie Bv Inhalable Medicaments
DE102013021718B4 (en) * 2013-12-20 2017-03-02 Gerresheimer Regensburg Gmbh Capsule for use as a reservoir for a pharmaceutical, preferably powdered preparation in an inhaler and inhaler therefor
USD752204S1 (en) * 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
USD755367S1 (en) * 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US20170182268A1 (en) * 2014-05-28 2017-06-29 Sanofi Sa Assembly for a counter mechanism for a drug delivery device and drug delivery device
MX2016016453A (en) 2014-06-13 2017-04-06 Microdose Therapeutx Inc Medical device communication.
MX2017002551A (en) * 2014-08-28 2017-09-26 Norton (Waterford) Ltd Compliance-assisting module for an inhaler.
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
DE102014017065B3 (en) * 2014-11-20 2015-11-19 Klaus-Dieter Beller Powder container for powder inhalers
US10058661B2 (en) 2014-12-04 2018-08-28 Norton (Waterford) Limited Inhalation monitoring system and method
MA41378A (en) 2015-01-20 2017-11-28 Teva Branded Pharmaceutical Prod R & D Inc DRY POWDER INHALER CONSISTING OF FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATE
TWI579008B (en) * 2015-03-06 2017-04-21 崑山科技大學 Drug mist inhalation auxiliaries
EP3304378A1 (en) 2015-06-03 2018-04-11 MicroDose Therapeutx, Inc. Medical device notification system
US10507293B2 (en) 2015-06-24 2019-12-17 Ethicon, Inc. Hemostatic powder delivery devices and methods
USD837365S1 (en) * 2016-06-16 2019-01-01 Koninklijke Philips N.V. Handheld secretion clearance device
GB201615186D0 (en) * 2016-09-07 2016-10-19 3M Innovative Properties Co Energy storage mechanism for an inhaler
USD832997S1 (en) * 2016-10-21 2018-11-06 Norton (Waterford) Limited Inhaler
USD852947S1 (en) * 2016-10-21 2019-07-02 Norton (Waterford) Limited Inhaler
USD832998S1 (en) * 2016-10-21 2018-11-06 Norton (Waterford) Limited Inhaler
ES2811842T3 (en) * 2016-11-18 2021-03-15 Norton Waterford Ltd Inhaler
CA3043965A1 (en) 2016-11-18 2018-05-24 Norton (Waterford) Limited Drug delivery device with electronics
USD853555S1 (en) * 2017-01-03 2019-07-09 Norton (Waterford) Limited Inhaler
WO2019212442A2 (en) * 2018-03-16 2019-11-07 Inofab Saglik Teknolojileri Anonim Sirketi Inhaler usage monitoring method
USD949323S1 (en) * 2019-07-26 2022-04-19 Lupin Ltd. Inhaler
USD948704S1 (en) * 2019-07-26 2022-04-12 Lupin Ltd. Inhaler
USD948703S1 (en) * 2019-07-26 2022-04-12 Lupin Ltd. Inhaler
USD949324S1 (en) * 2019-07-26 2022-04-19 Lupin Ltd. Inhaler

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8630100D0 (en) 1986-12-17 1987-01-28 Weston T E Pressurised metering dispenser
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
GB8917775D0 (en) * 1989-08-03 1989-09-20 Atomic Energy Authority Uk Aerosol inhaler
IT1237118B (en) * 1989-10-27 1993-05-18 Miat Spa MULTI-DOSE INHALER FOR POWDER DRUGS.
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
US5020527A (en) * 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
GB9025705D0 (en) * 1990-11-27 1991-01-09 Britains Petite Ltd Powder inhaler
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
GB9027234D0 (en) 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
WO1992017231A1 (en) * 1991-03-28 1992-10-15 Innomed, Inc. Microelectronic inhaler having a counter and timer
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
SE9201411D0 (en) 1992-05-05 1992-05-05 Astra Ab DOSAGE INHALATOR WITH INDICATING / INTERUPTING MEANS
IL106930A0 (en) 1992-09-08 1993-12-28 Norton Healthcare Ltd Medicament dispensing device
GB9218937D0 (en) 1992-09-08 1992-10-21 Norton Healthcare Ltd Medicament dispensing device
HU215510B (en) * 1992-12-18 1999-01-28 Schering Corp. Inhaler for powdered medications
FR2701653B1 (en) * 1993-02-18 1995-04-07 Valois Dosing device for the inhalation of dry powder.
GB9314614D0 (en) * 1993-07-14 1993-08-25 Minnesota Mining & Mfg Dry powder inhalers
FI942196A (en) * 1994-05-11 1995-11-12 Orion Yhtymae Oy powder inhaler
FR2721106B1 (en) * 1994-06-10 1996-09-13 Step Dose counter for inhalers.
JPH10505764A (en) * 1994-09-16 1998-06-09 ラボラトワール、グラクソ、ウェルカム Inhaler
US5544647A (en) * 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US6029659A (en) * 1995-04-17 2000-02-29 Solar Shield Corporation Inhalation device with counter
NZ502870A (en) * 1995-06-21 2001-06-29 Asta Medica Ag Inhaler for powdered medicaments comprising a visual display device to indicate the discharge status of the inhaler
FI102875B (en) * 1995-11-10 1999-03-15 Orion Yhtymae Oy The powder inhaler
DK0865302T3 (en) * 1995-12-07 2000-10-02 Jago Pharma Ag Inhalator for repeated dose delivery of pharmacological dry powder
US5833066A (en) * 1996-01-02 1998-11-10 Inhalermate, Llc Carrying case for oral and nasal inhalation devices with counting mechanism
ATE216903T1 (en) 1996-02-21 2002-05-15 Schering Corp INHALER FOR POWDER-TYPE MEDICATION
GB2320489A (en) * 1996-12-20 1998-06-24 Norton Healthcare Ltd Inhaler dose counter
GB9700226D0 (en) 1997-01-08 1997-02-26 Glaxo Group Ltd Inhalation device
SE9700940D0 (en) * 1997-03-14 1997-03-14 Astra Ab Powder inhales IV
WO1998052634A1 (en) * 1997-05-23 1998-11-26 Pa Knowledge Limited Inhaler mechanism
TW533865U (en) * 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
US6142339A (en) * 1998-01-16 2000-11-07 1263152 Ontario Inc. Aerosol dispensing device
GB9807558D0 (en) * 1998-04-09 1998-06-10 Bason Neil P An indicator device
US6336453B1 (en) * 1999-04-30 2002-01-08 Trudell Medical International Indicating device for aerosol container
US6082358A (en) * 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
AU3471799A (en) * 1998-07-06 2000-01-24 Iep Group, Inc. Counter for fluid dispenser
TWI224514B (en) * 2000-06-23 2004-12-01 Norton Healthcare Ltd Dose metering system for medicament inhaler
FR2811576B1 (en) * 2000-07-13 2003-01-24 Henri Bocquee APPARATUS OR APPARATUS FOR ADMINISTERING POWDERY ACTIVE PRODUCTS OF THE DRUG OR VACCINE TYPE, BY PULMONARY ROUTE

Also Published As

Publication number Publication date
JP4897569B2 (en) 2012-03-14
ATE548062T1 (en) 2012-03-15
PT1486227E (en) 2012-04-10
KR100518723B1 (en) 2005-10-05
DE60107107D1 (en) 2004-12-16
TWI224514B (en) 2004-12-01
JP4897570B2 (en) 2012-03-14
US7540282B2 (en) 2009-06-02
DK2314336T3 (en) 2014-11-03
EP2314336A2 (en) 2011-04-27
GB2365779B (en) 2004-09-29
GB0115525D0 (en) 2001-08-15
JP2007289716A (en) 2007-11-08
KR20050039884A (en) 2005-04-29
UY26794A1 (en) 2002-01-31
EP2314336A3 (en) 2013-07-10
PE20020074A1 (en) 2002-02-05
GB2365778A (en) 2002-02-27
JP4015943B2 (en) 2007-11-28
ES2233659T3 (en) 2005-06-16
CA2552468C (en) 2008-02-19
US6701917B2 (en) 2004-03-09
EP1486227A2 (en) 2004-12-15
PE20020163A1 (en) 2002-03-04
GB2366208B (en) 2004-10-13
GB0115519D0 (en) 2001-08-15
GB0115518D0 (en) 2001-08-15
ES2520966T3 (en) 2014-11-12
JP2004501685A (en) 2004-01-22
UY26796A1 (en) 2002-01-31
EP1330280A2 (en) 2003-07-30
GB2365779A (en) 2002-02-27
KR100518721B1 (en) 2005-10-05
US20020073996A1 (en) 2002-06-20
US20020078950A1 (en) 2002-06-27
EP2314336B1 (en) 2014-08-20
KR100517900B1 (en) 2005-10-04
ATE281861T1 (en) 2004-11-15
AU7011301A (en) 2002-01-08
DK1486227T3 (en) 2012-04-02
AU2001270113B2 (en) 2004-08-12
EP1486227A3 (en) 2007-02-21
CA2407262C (en) 2007-08-28
CA2407262A1 (en) 2002-01-03
PT2314336E (en) 2014-10-29
KR20030066328A (en) 2003-08-09
PE20020075A1 (en) 2002-02-05
DE60107107T2 (en) 2005-11-03
GB2366208A (en) 2002-03-06
EP1330280B1 (en) 2004-11-10
US6718972B2 (en) 2004-04-13
EP1486227B1 (en) 2012-03-07
US20020078949A1 (en) 2002-06-27
JP2007252946A (en) 2007-10-04
PT1330280E (en) 2005-04-29
US8006690B2 (en) 2011-08-30
WO2002000281A2 (en) 2002-01-03
UY26795A1 (en) 2002-01-31
WO2002000281A3 (en) 2003-01-03
US20090178678A1 (en) 2009-07-16
TWI224513B (en) 2004-12-01
KR20050048687A (en) 2005-05-24
GB2365778B (en) 2004-10-13
ES2382734T3 (en) 2012-06-13
TWI224512B (en) 2004-12-01

Similar Documents

Publication Publication Date Title
CA2552468A1 (en) Medicament inhaler
WO2001087391A3 (en) Inhaler with a dose counter
MXPA05009485A (en) Medicament dispensing device with a display indicative of the state of an internal medicament reservoir.
CA2225396A1 (en) Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
CA2017883A1 (en) Medicament inhalation device and formulation
DE69503487T2 (en) SOLE METER FOR DOSING INHALATOR
NZ524959A (en) Delivery system
CA2369700A1 (en) Powder inhaler
CA2235005A1 (en) Powder inhaler
AR035648A1 (en) DOSE COUNTER FOR AN INHALER TO ADMINISTER MEDICATIONS
CY1115748T1 (en) DRUG INHALATION DEVICE
AR034552A1 (en) DOSE MEASUREMENT SYSTEM FOR AN INHALER TO ADMINISTER MEDICATIONS

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20210623