CA2551058A1 - A meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials - Google Patents

A meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials Download PDF

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Publication number
CA2551058A1
CA2551058A1 CA002551058A CA2551058A CA2551058A1 CA 2551058 A1 CA2551058 A1 CA 2551058A1 CA 002551058 A CA002551058 A CA 002551058A CA 2551058 A CA2551058 A CA 2551058A CA 2551058 A1 CA2551058 A1 CA 2551058A1
Authority
CA
Canada
Prior art keywords
meter
connector
test strip
potential
current
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002551058A
Other languages
French (fr)
Other versions
CA2551058C (en
Inventor
Oliver William Hardwicke Davies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LifeScan Scotland Ltd
Original Assignee
Lifescan Scotland Limited
Oliver William Hardwicke Davies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifescan Scotland Limited, Oliver William Hardwicke Davies filed Critical Lifescan Scotland Limited
Publication of CA2551058A1 publication Critical patent/CA2551058A1/en
Application granted granted Critical
Publication of CA2551058C publication Critical patent/CA2551058C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/49Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/150022Source of blood for capillary blood or interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150358Strips for collecting blood, e.g. absorbent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150412Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A61B5/150435Specific design of proximal end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150503Single-ended needles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/005Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006Enzyme electrodes involving specific analytes or enzymes for glucose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

The present invention is directed to an improved meter that utilizes a method of reducing the effects of interfering compounds in the measurement of analytes and more particularly to a method of reducing the effects of interfering compounds in a system wherein the test strip utilizes two or more working electrodes. In the present invention, a meter is described which applies a first potential (E1) to a first working electrode (12) and a second potential (E2), having the same polarity but a greater magnitude than the first potential is applied to a second working electrode (14). The meter then measures the generated current and utilizes a predetermined algorithm to correct the measured current to compensate for the presence of interfering compounds in the sample.

Claims (4)

1. An improved meter for use in the detection of analytes, said meter comprising:
a first connector for connecting said meter to a first working electrode on said test strip;
a second connector for connecting said meter to a second working electrode on said test strip;
a common connector for connecting said meter to a reference electrode on said test strip;
a first voltage source connected between said first connector and said common connector;
a second voltage source connected between said second connector and said common connector.
2. An improved meter according to Claim 1 wherein said first and second voltage sources generate a first potential at said first connector and a second potential said second connector when a test strip is inserted into said meter and a sample is applied to said test strip, wherein said first and second voltages have the same polarity and said second potential has a magnitude greater than said first potential.
3. An improved meter according to Claim 2 wherein said meter measures a first current value at said first connector and a second current value at said second connector at a predetermined time after said test strip is inserted and sample applied.
4. An improved meter according to Claim 3 wherein said meter calculates a corrected value of analyte current using the following formula:
where: A1 is said corrected analyte current; W1 is the current at said first connector measured at said predetermined time; W2 is the current measured at said second connector at said predetermined time; X is an analyte dependent voltage effect factor;
and Y is an interfering compound dependent voltage effect factor.
CA2551058A 2003-10-31 2004-10-29 A meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials Expired - Fee Related CA2551058C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US51625203P 2003-10-31 2003-10-31
US60/516,252 2003-10-31
US55872804P 2004-03-31 2004-03-31
US55842404P 2004-03-31 2004-03-31
US60/558,424 2004-03-31
US60/558,728 2004-03-31
PCT/GB2004/004594 WO2005045415A1 (en) 2003-10-31 2004-10-29 A meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials

Publications (2)

Publication Number Publication Date
CA2551058A1 true CA2551058A1 (en) 2005-05-19
CA2551058C CA2551058C (en) 2012-10-23

Family

ID=34577659

Family Applications (6)

Application Number Title Priority Date Filing Date
CA002543802A Abandoned CA2543802A1 (en) 2003-10-31 2004-10-29 Method of reducing the effect of direct and mediated interference current in an electrochemical test strip
CA2543797A Expired - Fee Related CA2543797C (en) 2003-10-31 2004-10-29 A method of reducing interferences in an electrochemical sensor using two different applied potentials
CA2551058A Expired - Fee Related CA2551058C (en) 2003-10-31 2004-10-29 A meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials
CA002543961A Abandoned CA2543961A1 (en) 2003-10-31 2004-10-29 Electrochemical test strip for reducing the effect of direct and mediated interference current
CA2543957A Active CA2543957C (en) 2003-10-31 2004-10-29 Method of reducing the effect of direct interference current in an electrochemical test strip
CA002544424A Abandoned CA2544424A1 (en) 2003-10-31 2004-10-29 Electrochemical test strip for reducing the effect of direct interference current

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA002543802A Abandoned CA2543802A1 (en) 2003-10-31 2004-10-29 Method of reducing the effect of direct and mediated interference current in an electrochemical test strip
CA2543797A Expired - Fee Related CA2543797C (en) 2003-10-31 2004-10-29 A method of reducing interferences in an electrochemical sensor using two different applied potentials

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA002543961A Abandoned CA2543961A1 (en) 2003-10-31 2004-10-29 Electrochemical test strip for reducing the effect of direct and mediated interference current
CA2543957A Active CA2543957C (en) 2003-10-31 2004-10-29 Method of reducing the effect of direct interference current in an electrochemical test strip
CA002544424A Abandoned CA2544424A1 (en) 2003-10-31 2004-10-29 Electrochemical test strip for reducing the effect of direct interference current

Country Status (16)

Country Link
US (7) US20050139469A1 (en)
EP (6) EP1685393B1 (en)
JP (6) JP4652334B2 (en)
KR (5) KR20070027497A (en)
AT (4) ATE354796T1 (en)
AU (6) AU2004288008B2 (en)
CA (6) CA2543802A1 (en)
DE (4) DE602004004929T2 (en)
DK (3) DK1685393T3 (en)
ES (4) ES2343184T3 (en)
HK (4) HK1091896A1 (en)
IL (6) IL175321A0 (en)
PL (3) PL1678490T3 (en)
PT (2) PT1685393E (en)
SG (2) SG131942A1 (en)
WO (6) WO2005045415A1 (en)

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