CA2531833A1 - Poly-4-hydroxybutyrate matrices for sustained drug delivery - Google Patents
Poly-4-hydroxybutyrate matrices for sustained drug delivery Download PDFInfo
- Publication number
- CA2531833A1 CA2531833A1 CA002531833A CA2531833A CA2531833A1 CA 2531833 A1 CA2531833 A1 CA 2531833A1 CA 002531833 A CA002531833 A CA 002531833A CA 2531833 A CA2531833 A CA 2531833A CA 2531833 A1 CA2531833 A1 CA 2531833A1
- Authority
- CA
- Canada
- Prior art keywords
- hydroxybutyrate
- poly
- drug delivery
- systems
- drugs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Abstract
Biodegradable controlled release systems providing prolonged controlled release of drugs, and methods for the manufacture thereof are disclosed. The systems are formed from a biocompatible, biodegradable polymer, in particular poly-4-hydroxybutyrate (PHA4400) or copolymers thereof. Copolymers of 4-hydroxybutyrate include but are not limited to poly-3-hydroxybutyrate-co-4-hydroxybutyrate (PHA3444), and poly-4-hydoxybutyrate-co-glycolate (PHA4422).
Drugs are generally incorporated into the polymer using a method that yields a uniform dispersion. The type of drug and the quantity are selected based on the known pharmaceutical properties of these compounds. The systems may be administered for example by implantation, injection, topical administration, or oral ingestion. They may also be used in combination with a medical device, for example, a stent. A major advantage of the drug delivery system is that it does not need to be removed after use since it is slowly degraded and cleared by the patient's body. The device has desirable physical properties, including strength, modulus and elongation.
Drugs are generally incorporated into the polymer using a method that yields a uniform dispersion. The type of drug and the quantity are selected based on the known pharmaceutical properties of these compounds. The systems may be administered for example by implantation, injection, topical administration, or oral ingestion. They may also be used in combination with a medical device, for example, a stent. A major advantage of the drug delivery system is that it does not need to be removed after use since it is slowly degraded and cleared by the patient's body. The device has desirable physical properties, including strength, modulus and elongation.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48537303P | 2003-07-08 | 2003-07-08 | |
US60/485,373 | 2003-07-08 | ||
US49143003P | 2003-07-30 | 2003-07-30 | |
US60/491,430 | 2003-07-30 | ||
PCT/US2004/022040 WO2005007195A1 (en) | 2003-07-08 | 2004-07-08 | Poly-4-hydroxybutyrate matrices for sustained drug delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2531833A1 true CA2531833A1 (en) | 2005-01-27 |
CA2531833C CA2531833C (en) | 2009-10-20 |
Family
ID=34083339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002531833A Active CA2531833C (en) | 2003-07-08 | 2004-07-08 | Poly-4-hydroxybutyrate matrices for sustained drug delivery |
Country Status (7)
Country | Link |
---|---|
US (1) | US20050025809A1 (en) |
EP (1) | EP1651273B1 (en) |
JP (1) | JP2007528853A (en) |
AU (1) | AU2004257701B2 (en) |
CA (1) | CA2531833C (en) |
ES (1) | ES2395077T3 (en) |
WO (1) | WO2005007195A1 (en) |
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US6838492B2 (en) * | 2002-06-17 | 2005-01-04 | Scentco, Llc. | Scented paints, paint scenting additive mixtures and processes for producing scented paints |
PT1778305E (en) * | 2004-08-03 | 2010-07-27 | Tepha Inc | Non-curling polyhydroxyalkanoate sutures |
-
2004
- 2004-07-08 WO PCT/US2004/022040 patent/WO2005007195A1/en active Search and Examination
- 2004-07-08 EP EP04777860A patent/EP1651273B1/en active Active
- 2004-07-08 CA CA002531833A patent/CA2531833C/en active Active
- 2004-07-08 US US10/886,851 patent/US20050025809A1/en not_active Abandoned
- 2004-07-08 JP JP2006518932A patent/JP2007528853A/en active Pending
- 2004-07-08 ES ES04777860T patent/ES2395077T3/en active Active
- 2004-07-08 AU AU2004257701A patent/AU2004257701B2/en active Active
Also Published As
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WO2005007195A1 (en) | 2005-01-27 |
AU2004257701B2 (en) | 2007-09-13 |
ES2395077T3 (en) | 2013-02-08 |
US20050025809A1 (en) | 2005-02-03 |
CA2531833C (en) | 2009-10-20 |
AU2004257701A1 (en) | 2005-01-27 |
EP1651273A1 (en) | 2006-05-03 |
JP2007528853A (en) | 2007-10-18 |
EP1651273B1 (en) | 2012-08-29 |
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