CA2529579A1 - Biosensor with multiple electrical functionalities - Google Patents
Biosensor with multiple electrical functionalities Download PDFInfo
- Publication number
- CA2529579A1 CA2529579A1 CA002529579A CA2529579A CA2529579A1 CA 2529579 A1 CA2529579 A1 CA 2529579A1 CA 002529579 A CA002529579 A CA 002529579A CA 2529579 A CA2529579 A CA 2529579A CA 2529579 A1 CA2529579 A1 CA 2529579A1
- Authority
- CA
- Canada
- Prior art keywords
- biosensor
- fluid sample
- disposed
- receiving chamber
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012530 fluid Substances 0.000 claims abstract 14
- 238000005259 measurement Methods 0.000 claims abstract 8
- 239000012491 analyte Substances 0.000 claims 10
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 230000000007 visual effect Effects 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 1
- 238000012937 correction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 238000009429 electrical wiring Methods 0.000 abstract 1
- 238000010248 power generation Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
Abstract
A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated.
Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
Claims (20)
1. A biosensor for analyzing a fluid sample, comprising:
a biosensor body defining a measurement zone having a sample receiving chamber in which is disposed a measurement electrode for detecting the presence or concentration of an analyte in the fluid sample, the sample receiving chamber including a reagent which reacts with the fluid sample; and the biosensor body further defining a user interface zone in which is disposed an electrically driven signal generator which emits a visible, audible or tactile signal upon the occurrence of a triggering event.
a biosensor body defining a measurement zone having a sample receiving chamber in which is disposed a measurement electrode for detecting the presence or concentration of an analyte in the fluid sample, the sample receiving chamber including a reagent which reacts with the fluid sample; and the biosensor body further defining a user interface zone in which is disposed an electrically driven signal generator which emits a visible, audible or tactile signal upon the occurrence of a triggering event.
2. A biosensor for analyzing a fluid sample, comprising:
a biosensor body defining a measurement zone having a sample receiving chamber in which is disposed a measurement electrode for detecting the presence or concentration of an analyte in the fluid sample, the sample receiving chamber including a reagent which reacts with the fluid sample; and the biosensor body further including at least four electrical devices positioned on or in the biosensor body, the electrical devices comprising one or more electrodes, power generators, digital devices or electrically driven signal generators, wherein two of the at least four electrical devices comprise first and second sets of electrodes disposed at least partially within the sample receiving chamber, one of the first and second sets of electrodes being for determining the presence or estimating the concentration of an analyte in the fluid sample.
a biosensor body defining a measurement zone having a sample receiving chamber in which is disposed a measurement electrode for detecting the presence or concentration of an analyte in the fluid sample, the sample receiving chamber including a reagent which reacts with the fluid sample; and the biosensor body further including at least four electrical devices positioned on or in the biosensor body, the electrical devices comprising one or more electrodes, power generators, digital devices or electrically driven signal generators, wherein two of the at least four electrical devices comprise first and second sets of electrodes disposed at least partially within the sample receiving chamber, one of the first and second sets of electrodes being for determining the presence or estimating the concentration of an analyte in the fluid sample.
3. The biosensor of claim 2, wherein one of the electrical devices comprises a third set of electrodes at least partially disposed within the sample receiving chamber for determining a correction factor for analyte concentration based on the detection of interferents in the fluid sample.
4. The biosensor of claims 2 or 3, wherein all four electrical devices comprise electrode sets disposed at least partially within the sample receiving chamber.
5. The biosensor of any of claims 2-4, wherein the biosensor body defines a user interface zone and one of the electrical devices comprises an electrically driven signal generator which is disposed in the user interface zone and which emits a visible, audible or tactile signal upon the occurrence of a triggering event.
6. The biosensor of claims 1 or 5 in which the triggering event is independent of the concentration of the analyte.
7. The biosensor of claim 6, wherein the triggering event is proper insertion of the strip into a meter or sufficient filling of the sample receiving chamber.
8. The biosensor of any of claims 1 or 5-7, wherein the signal generator comprises a light which illuminates a portion of the test strip.
9. The biosensor of any of claims 1 or 5-8, wherein the signal generator comprises an OLED or LED.
10. The biosensor of claims 1 or 5 in which the electrically driven signal generator is a numerical display for displaying the concentration of an analyte in the fluid sample.
11. The biosensor of any of the preceding claims, wherein the biosensor body further comprises a digital information zone in which is disposed a digital device.
12. The biosensor of claim 11, wherein the digital device comprises an RFID tag.
13. The biosensor of claims 11 or 12, wherein the digital device is encoded with at least one of the type of analyte, a lot code and an expiration date of the biosensor.
14. A biosensor for analyzing a fluid sample, comprising:
a biosensor body defining a measurement zone having a sample receiving chamber in which is disposed a measurement electrode for detecting the presence or concentration of an analyte in the fluid sample, the sample receiving chamber including a reagent which reacts with the fluid sample; and the biosensor body further including a power generator.
a biosensor body defining a measurement zone having a sample receiving chamber in which is disposed a measurement electrode for detecting the presence or concentration of an analyte in the fluid sample, the sample receiving chamber including a reagent which reacts with the fluid sample; and the biosensor body further including a power generator.
15. The biosensor of claim 14, wherein the biosensor body further includes at least one of a user interface zone in which is disposed an electrically driven signal generator which emits a visible, audible or tactile signal upon occurrence of a triggering event, and a digital information zone in which is disposed a digital device, the power generator driving the at least one of the signal generator and the digital device.
16. The biosensor of any of the preceding claims, wherein the biosensor body is substantially flat.
17. The biosensor of any of the preceding claims, wherein the sample receiving chamber is sized to draw in the fluid sample by capillary action.
18. A method comprising:
providing a biosensor adapted to detect an analyte in a sample and having an electrically driven visual indicator;
inserting the biosensor into a meter; and activating the visual indicator with the meter to communicate a condition of the biosensor to the user, wherein the condition is independent of the concentration of the analyte.
providing a biosensor adapted to detect an analyte in a sample and having an electrically driven visual indicator;
inserting the biosensor into a meter; and activating the visual indicator with the meter to communicate a condition of the biosensor to the user, wherein the condition is independent of the concentration of the analyte.
19. The method of claim 18 wherein the condition is proper insertion of the biosensor into the meter.
20. The method of any of claims 18 or 19 wherein the condition is sufficient filling of a sample chamber in the biosensor.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48024303P | 2003-06-20 | 2003-06-20 | |
US60/480,243 | 2003-06-20 | ||
PCT/US2004/019652 WO2005012900A1 (en) | 2003-06-20 | 2004-06-18 | Biosensor with multiple electrical functionalities |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2529579A1 true CA2529579A1 (en) | 2005-02-10 |
CA2529579C CA2529579C (en) | 2011-01-25 |
Family
ID=33539277
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2529300A Expired - Fee Related CA2529300C (en) | 2003-06-20 | 2004-06-18 | Devices and methods relating to electrochemical biosensors |
CA2529579A Expired - Fee Related CA2529579C (en) | 2003-06-20 | 2004-06-18 | Biosensor with multiple electrical functionalities |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2529300A Expired - Fee Related CA2529300C (en) | 2003-06-20 | 2004-06-18 | Devices and methods relating to electrochemical biosensors |
Country Status (13)
Country | Link |
---|---|
US (3) | US8506775B2 (en) |
EP (3) | EP3376223A1 (en) |
JP (2) | JP4489073B2 (en) |
KR (2) | KR100845163B1 (en) |
CN (1) | CN1839313B (en) |
AU (1) | AU2004250223B2 (en) |
BR (1) | BRPI0411695A (en) |
CA (2) | CA2529300C (en) |
ES (1) | ES2657627T3 (en) |
HK (1) | HK1096151A1 (en) |
MX (1) | MXPA05013747A (en) |
PL (1) | PL1642124T3 (en) |
WO (2) | WO2004113910A1 (en) |
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- 2004-06-18 BR BRPI0411695-0A patent/BRPI0411695A/en not_active IP Right Cessation
- 2004-06-18 KR KR1020077018681A patent/KR20070100362A/en not_active Application Discontinuation
- 2004-06-18 EP EP17204072.7A patent/EP3376223A1/en active Pending
- 2004-06-18 JP JP2006517450A patent/JP4489073B2/en not_active Expired - Fee Related
- 2004-06-18 AU AU2004250223A patent/AU2004250223B2/en not_active Ceased
- 2004-06-18 ES ES04776780.1T patent/ES2657627T3/en active Active
- 2004-06-18 WO PCT/US2004/019652 patent/WO2005012900A1/en active Search and Examination
- 2004-06-18 CA CA2529300A patent/CA2529300C/en not_active Expired - Fee Related
- 2004-06-18 US US10/871,843 patent/US7867369B2/en not_active Expired - Fee Related
- 2004-06-18 EP EP04776780.1A patent/EP1642124B1/en active Active
- 2004-06-18 JP JP2006517421A patent/JP4624999B2/en active Active
- 2004-06-18 PL PL04776780T patent/PL1642124T3/en unknown
- 2004-06-18 EP EP04776796.7A patent/EP1642125B1/en not_active Not-in-force
- 2004-06-18 CA CA2529579A patent/CA2529579C/en not_active Expired - Fee Related
- 2004-06-18 MX MXPA05013747A patent/MXPA05013747A/en active IP Right Grant
- 2004-06-18 CN CN2004800237191A patent/CN1839313B/en active Active
-
2007
- 2007-03-22 HK HK07103092.4A patent/HK1096151A1/en unknown
-
2013
- 2013-07-08 US US13/936,268 patent/US20130292266A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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CA2529300A1 (en) | 2004-12-29 |
CA2529300C (en) | 2011-10-18 |
PL1642124T3 (en) | 2018-04-30 |
EP1642124A1 (en) | 2006-04-05 |
EP3376223A1 (en) | 2018-09-19 |
US20130292266A1 (en) | 2013-11-07 |
CN1839313A (en) | 2006-09-27 |
US7867369B2 (en) | 2011-01-11 |
KR100845163B1 (en) | 2008-07-09 |
ES2657627T3 (en) | 2018-03-06 |
HK1096151A1 (en) | 2007-05-25 |
US8506775B2 (en) | 2013-08-13 |
CN1839313B (en) | 2011-12-14 |
AU2004250223B2 (en) | 2007-12-13 |
JP4489073B2 (en) | 2010-06-23 |
JP2007521484A (en) | 2007-08-02 |
JP4624999B2 (en) | 2011-02-02 |
BRPI0411695A (en) | 2006-09-19 |
WO2005012900A1 (en) | 2005-02-10 |
EP1642125B1 (en) | 2017-09-27 |
CA2529579C (en) | 2011-01-25 |
KR20070100362A (en) | 2007-10-10 |
EP1642125A1 (en) | 2006-04-05 |
WO2004113910A1 (en) | 2004-12-29 |
US20050023137A1 (en) | 2005-02-03 |
US20050023152A1 (en) | 2005-02-03 |
JP2007524818A (en) | 2007-08-30 |
AU2004250223A1 (en) | 2004-12-29 |
EP1642124B1 (en) | 2017-11-29 |
KR20060022286A (en) | 2006-03-09 |
MXPA05013747A (en) | 2006-03-08 |
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