CA2521117A1 - Ultrasnoic method and device for wound treatment - Google Patents

Ultrasnoic method and device for wound treatment Download PDF

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Publication number
CA2521117A1
CA2521117A1 CA002521117A CA2521117A CA2521117A1 CA 2521117 A1 CA2521117 A1 CA 2521117A1 CA 002521117 A CA002521117 A CA 002521117A CA 2521117 A CA2521117 A CA 2521117A CA 2521117 A1 CA2521117 A1 CA 2521117A1
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Canada
Prior art keywords
ultrasonic energy
wound
tissue
therapeutic effect
achieving
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Granted
Application number
CA002521117A
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French (fr)
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CA2521117C (en
Inventor
Eilaz Babaev
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Individual
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Individual
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Priority claimed from US10/409,272 external-priority patent/US8235919B2/en
Application filed by Individual filed Critical Individual
Publication of CA2521117A1 publication Critical patent/CA2521117A1/en
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Publication of CA2521117C publication Critical patent/CA2521117C/en
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Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0275—Pulsating jets; Vibrating nozzles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

An apparatus and method are provided for applying a medicament to tissue, and delivering ultrasonic energy from a non-contact distance from the tissue to the medicament and to the tissue, wherein the ultrasonic energy has intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect to the tissue, and of sonicating the medicament for causing the medicament to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue. Another apparatus and method are provided for generating ultrasonic energy from a non-contact distance from the surface of the wound; and delivering the generated ultrasonic energy to the wound through a gaseous medium. The generated ultrasonic energy has a significantly large amplitude such that the ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound.

Claims (74)

WHAT IS CLAIMED IS:
1. A method for treating tissue using ultrasonic energy comprising the steps of:
applying a medicament to tissue; and delivering ultrasonic energy from a non-contact distance from the tissue to the medicament and to the tissue, wherein the ultrasonic energy has intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect to the tissue, and of sonicating the medicament for causing the medicament to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue.
2. The method according to Claim 1, wherein the ultrasonic energy has an intensity capable of penetrating the tissue to a beneficial depth to provide a therapeutic effect to the tissue.
3. The method according to Claim 1, further including the step of generating the ultrasonic energy with a particular amplitude indicative of an intensity capable of achieving the therapeutic effect.
4. The method according to Claim 3, further including the step of generating the ultrasonic energy with a frequency capable of achieving the particular amplitude.
5. The method according to Claim 3, wherein the particular amplitude is at least 3 microns.
6. The method according to Claim 1, wherein the ultrasonic energy is delivered simultaneously with delivery of a spray to the tissue.
7. The method according to Claim 1, wherein the ultrasonic energy is delivered through a substantial expanse of a substantially purely gaseous medium including air to the tissue.
8. The method according to Claim 3, wherein the particular amplitude is at least 10 microns.
9. The method according to Claim 4, wherein the frequency is in the range of 20kHz-5MHz.
10. The method according to Claim 4, wherein the frequency is in the range of 2.0-200kHz.
11. The method according to Claim 4, wherein the frequency is in the range of 40kHz.
12. The method according to Claim 1, wherein the applying step is performed prior to the delivery step.
13. The method according to Claim 1, wherein the applying step is performed during the delivering step.
14. The method according to Claim 1, wherein the steps of the method are included in a series of treatments wherein another treatment of the series of treatments is selected from the group consisting of:
the treatment including the steps of delivering ultrasonic energy from a non-contact distance to the tissue simultaneous with delivery of a spray to the tissue, wherein the ultrasonic energy has an intensity capable of penetrating the tissue to a beneficial depth to provide a therapeutic effect to the tissue and sonicating the spray for causing the spray to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue;
the treatment including the steps of delivering ultrasonic energy from a non-contact distance to the tissue through a substantial expense of a substantially purely gaseous medium to the tissue, wherein the ultrasonic energy has an intensity capable of penetrating the tissue to a beneficial depth to provide a therapeutic effect to the tissue; and the treatment including the steps of the method of the invention, wherein a different medicament is applied.
15. The method according to Claim 1, wherein the medicament is selected from the group consisting of: an antibiotic, an ointment, cream, gel, liquid, salve, oil, saline solution, distilled, non-distilled and/or boiled water, powder, spray, antibacterial agent, antiseptic agent, insulin, analgesic agent, conditioner, surfactant, emollient, or other active ingredient.
16. The method according to Claim 1, wherein the step of delivering includes the step of providing means for delivering the ultrasonic energy at a distance from 2.5mm-51cm from the tissue.
17. The method according to Claim 1, wherein the therapeutic effect is selected from the group consisting of increasing blood flow to the tissue, providing a local anesthetic effect and stimulating cell growth.
18. An apparatus for treating tissue comprising:
a generator and a transducer for generating ultrasonic energy;
wherein the transducer delivers the ultrasonic energy to the tissue and to a medicament applied to the tissue from a non-contact distance from the tissue; and wherein the generated ultrasonic energy has an intensity capable of applying acoustic pressure and penetrating the wound tissue to a beneficial depth to provide a therapeutic effect to the tissue, and of sonicating the medicament for causing the medicament to penetrate the tissue to a beneficial depth to provide a therapeutic effect to the tissue.
19. The apparatus according to Claim 18, wherein the generator and transducer generate the ultrasonic energy with a particular amplitude indicative of an intensity capable of achieving the therapeutic effect.
20. The apparatus according to Claim 19, wherein the generator and transducer further generates the ultrasonic energy with a frequency capable of achieving the particular amplitude.
21. The apparatus according to Claim 19, wherein the particular amplitude is at least microns.
22. The apparatus according to Claim 20, wherein the frequency is in the range of 20kHz-5MHz.
23. The apparatus according to Claim 20, wherein the frequency is in the range of 20-200kHz.
24. The apparatus according to Claim 20, wherein the frequency is in the range of 20-40kHz.
25. The apparatus according to Claim 18, wherein the transducer includes a radiation surface having a surface area dimensioned for achieving delivery of the ultrasonic energy to the tissue with an intensity capable of achieving the therapeutic effect.
26. The apparatus according to Claim 18, wherein the transducer includes a radiation surface having at least one of a rounded and rectangular perimeter for achieving delivery of the ultrasonic energy to the tissue with an intensity capable of achieving the therapeutic effect.
27. The apparatus according to Claim 18, wherein the transducer includes a radiation surface; and a selection is made of at least one of a size of a surface area of the radiation surface, a shape of a peripheral boundary of the radiation surface, a frequency of the generated ultrasonic energy, and an amplitude of the generated ultrasonic energy for achieving delivery of ultrasonic energy to the tissue with an intensity capable of achieving the therapeutic effect.
28. The apparatus according to Claim 18, wherein the transducer includes a radiation surface; and a selection is made of a combination of a size of a surface area of the radiation surface, a shape of a peripheral boundary of the radiation surface, a shape of the curvature of the radiation surface selected from one of flat, concave, convex and a combination thereof, a frequency of the generated ultrasonic energy, and an amplitude of the generated ultrasonic energy for achieving delivery of ultrasonic energy to the tissue with an intensity capable of achieving the therapeutic effect.
29. The apparatus according to Claim 18, wherein a radiation surface of the transducer is positioned from 2.5mm to 51cm from the tissue.
30. The apparatus according to Claim 18, wherein the transducer is driven by a constant or modulated frequency and wherein the driving wave form of the transducer is selected from the group consisting of sinusoidal, rectangular, trapezoidal and triangular wave forms.
31. The apparatus according to Claim 18, wherein the therapeutic effect is selected from the group consisting of increasing blood flow to the tissue, providing a local anesthetic affect and stimulating cell growth.
32. The apparatus according to Claim 18, wherein the ultrasonic energy is delivered simultaneously with delivery of a spray to the tissue.
33. The apparatus according to Claim 18, wherein the ultrasonic energy is delivered through a substantial expanse of a substantially purely gaseous medium to the tissue.
34. The apparatus according to Claim 18, wherein the medicament is applied to the tissue prior to sonication of the medicament.
35. The apparatus according to Claim 18, wherein the medicament is applied during delivery of the ultrasonic energy.
36. The apparatus according to Claim 18, wherein the medicament is selected from the group consisting of: an ointment, cream, gel, liquid, salve, oil, saline solution, powder, spray, antibacterial agent, antiseptic agent, insulin, analgesic agent, conditioner, surfactant, emollient, or other active ingredient.
37. A method for treating a wound comprising the steps of:
generating ultrasonic energy; and delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound.
38. The method according to Claim 37, wherein the generating step includes generating the ultrasonic energy with a particular amplitude indicative of an intensity capable of achieving the therapeutic effect.
39. The method according to Claim 38, wherein the generating step further includes the step of generating the ultrasonic energy with a frequency capable of achieving the particular amplitude.
40. The method according to Claim 38, wherein the particular amplitude is at least 3 microns.
41. The method according to Claim 38, wherein the particular amplitude is at least 10 microns.
42. The method according to Claim 40, wherein the frequency is in the range of 20kHz-5MHz.
43. The method according to Claim 40, wherein the frequency is in the range of 200kHz.
44. The method according to Claim 40, wherein the frequency is in the range of 40kHz.
45. The method according to Claim 37, further comprising the step of providing a transducer for delivering the ultrasonic energy, said transducer having a radiation surface with a surface area dimensioned for achieving delivery of the ultrasonic energy to the wound with an intensity capable of achieving the therapeutic effect.
46. The method according to Claim 37, further comprising the step of providing a transducer for delivering the ultrasonic energy, said transducer having a radiation surface with a rounded perimeter for achieving delivery of the ultrasonic energy to the wound with an intensity capable of achieving the therapeutic effect.
47. The method according to Claim 37, further comprising the steps of:
providing a transducer for delivering the ultrasonic energy having a radiation surface; and selecting at least one of a size of a surface area of the radiation surface, a shape of a peripheral boundary of the radiation surface, a frequency of the generated ultrasonic energy, and an amplitude of the generated ultrasonic energy for achieving delivery of ultrasonic energy to the wound with an intensity capable of achieving the therapeutic effect.
48. The method according to Claim 37, further comprising the steps of:
providing a transducer for delivering the ultrasonic energy having a radiation surface;
and selecting a combination of a size of a surface area of the radiation surface, a shape of a peripheral boundary of the radiation surface, a shape of the curvature of the radiation surface selected from one of flat, concave, convex and a combination thereof, a frequency of the generated ultrasonic energy, and an amplitude of the generated ultrasonic energy for achieving delivery of ultrasonic energy to the wound with an intensity capable of achieving the therapeutic effect.
49. The method according to Claim 37, wherein the radiation surface is positioned from 2.5mm-51cm from the surface of the wound.
50. The method according to Claim 37, wherein the generating step includes the step of generating the ultrasonic energy with a constant or modulated frequency having a wave form selected from the group consisting of sinusoidal, rectangular, trapezoidal and triangular wave forms.
51. The method according to Claim 37, wherein the therapeutic effect is selected from the group consisting of increasing blood flow to the wound and stimulating cell growth.
52. An apparatus for treating a wound comprising:
means for generating ultrasonic energy; and means for delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound.
53. The apparatus according to Claim 52, wherein the means for generating includes means for generating the ultrasonic energy with a particular amplitude indicative of an intensity capable of achieving the therapeutic effect.
54. The apparatus according to Claim 53, wherein the means for generating further includes the means for generating the ultrasonic energy with a frequency capable of achieving the particular amplitude.
55. The apparatus according to Claim 53, wherein the particular amplitude is at least microns.
56. The apparatus according to Claim 54, wherein the frequency is in the range of 20kHz-5MHz.
57. The apparatus according to Claim 54, wherein the frequency is in the range of 20-200kHz.
5g. The apparatus according to Claim 54, wherein the frequency is in the range of 20 40kHz.
59. The apparatus according to Claim 52, wherein the means for delivering includes a radiation surface having a surface area dimensioned for achieving delivery of the ultrasonic energy to the wound with an intensity capable of achieving the therapeutic effect.
60. The apparatus according to Claim 52, wherein the means for delivering includes a radiation surface having a rounded perimeter for achieving delivery of the ultrasonic energy to the wound with an intensity capable of achieving the therapeutic effect.
61. The apparatus according to Claim 52, wherein the means for delivering includes a radiation surface; and a selection is made of at least one of a size of a surface area of the radiation surface, a shape of a peripheral boundary of the radiation surface, a frequency of the generated ultrasonic energy, and an amplitude of the generated ultrasonic energy for achieving delivery of ultrasonic energy to the wound with an intensity capable of achieving the therapeutic effect.
62. The apparatus according to Claim 52, wherein the means for delivering includes a radiation surface; and a selection is made of a combination of a size of a surface area of the radiation surface, a shape of a peripheral boundary of the radiation surface, a shape of the curvature of the radiation surface selected from one of flat, concave, convex and a combination thereof, a frequency of the generated ultrasonic energy, and an amplitude of the generated ultrasonic energy for achieving delivery of ultrasonic energy to the wound with an intensity capable of achieving the therapeutic effect.
63. The apparatus according to Claim 52, wherein a radiation surface of the means for delivering is positioned from 2.5mm to 51cm from the surface of the wound.
64. The apparatus according to Claim 52, wherein the means for delivering is driven by a constant or modulated frequency having a wave form selected from the group consisting of sinusoidal, rectangular, trapezoidal and triangular wave forms.
65. The apparatus according to Claim 52, wherein the therapeutic effect is selected from the group consisting of increasing blood flow to the wound and stimulating cell growth.
66. A method for treating a wound comprising the steps of:
generating ultrasonic energy having a particular amplitude; and delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound, wherein the particular amplitude is indicative of an intensity capable of achieving the therapeutic effect.
67. A method for treating a wound comprising the steps of:
generating ultrasonic energy having a frequency; and delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound, wherein the frequency is capable of achieving a particular amplitude indicative of an intensity capable of achieving the therapeutic effect.
68. A method for treating a wound comprising the steps of:
generating ultrasonic energy having an amplitude of at least 3 microns; and delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound.
69. The method according to Claim 68, wherein the ultrasonic energy has an amplitude of at least 10 microns.
70. An apparatus for treating a wound comprising:
means for generating ultrasonic energy having a particular amplitude; and means for delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound, wherein the particular amplitude is indicative of an intensity capable of achieving the therapeutic effect.
71. An apparatus for treating a wound comprising:
means for generating ultrasonic energy having a frequency; and means for delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound, wherein the frequency is capable of achieving a particular amplitude indicative of an intensity capable of achieving the therapeutic effect.
72. An apparatus for treating a wound comprising:
means for generating ultrasonic energy having an amplitude of at least 10 microns; and means for delivering the generated ultrasonic energy to the wound through a gaseous medium from a non-contact distance from the surface of the wound, wherein the generated ultrasonic energy has an intensity capable of penetrating the wound tissue to a beneficial depth to provide a therapeutic effect for decreasing the healing time for the wound.
73. The method according to Claim 37, wherein the gaseous medium includes a substantial expanse of a substantially purely gaseous medium.
74. The method according to Claim 52, wherein the gaseous medium includes a substantial expanse of a substantially purely gaseous medium.
CA2521117A 2003-04-07 2004-04-05 Ultrasnoic method and device for wound treatment Expired - Lifetime CA2521117C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/409,272 2003-04-07
US10/409,272 US8235919B2 (en) 2001-01-12 2003-04-07 Ultrasonic method and device for wound treatment
US10/815,384 US7914470B2 (en) 2001-01-12 2004-04-01 Ultrasonic method and device for wound treatment
US10/815,384 2004-04-01
PCT/US2004/010448 WO2004091722A1 (en) 2003-04-07 2004-04-05 Ultrasonic mehod and device for wound treatment

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CA2521117A1 true CA2521117A1 (en) 2004-10-28
CA2521117C CA2521117C (en) 2012-06-12

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US (2) US7914470B2 (en)
EP (1) EP1617910A1 (en)
JP (1) JP2007521053A (en)
CA (1) CA2521117C (en)
WO (1) WO2004091722A1 (en)

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US7914470B2 (en) 2011-03-29
CA2521117C (en) 2012-06-12
WO2004091722A8 (en) 2006-05-18
WO2004091722A1 (en) 2004-10-28
JP2007521053A (en) 2007-08-02
EP1617910A1 (en) 2006-01-25
US20040186384A1 (en) 2004-09-23
US20110230795A1 (en) 2011-09-22

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