CA2519195A1 - Adhesive patch containing non-steroidal anti-inflammatory agent - Google Patents
Adhesive patch containing non-steroidal anti-inflammatory agent Download PDFInfo
- Publication number
- CA2519195A1 CA2519195A1 CA002519195A CA2519195A CA2519195A1 CA 2519195 A1 CA2519195 A1 CA 2519195A1 CA 002519195 A CA002519195 A CA 002519195A CA 2519195 A CA2519195 A CA 2519195A CA 2519195 A1 CA2519195 A1 CA 2519195A1
- Authority
- CA
- Canada
- Prior art keywords
- steroidal anti
- inflammatory agent
- zinc
- patch containing
- stearate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 title claims abstract 16
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 title claims abstract 16
- 239000000853 adhesive Substances 0.000 title claims abstract 11
- 230000001070 adhesive effect Effects 0.000 title claims abstract 11
- 150000003839 salts Chemical class 0.000 claims abstract 12
- 239000012790 adhesive layer Substances 0.000 claims abstract 6
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 6
- 229930195729 fatty acid Natural products 0.000 claims 6
- 150000004665 fatty acids Chemical class 0.000 claims 6
- 229910052751 metal Inorganic materials 0.000 claims 6
- 239000002184 metal Substances 0.000 claims 6
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 4
- 229960001259 diclofenac Drugs 0.000 claims 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 4
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims 4
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 2
- 235000013539 calcium stearate Nutrition 0.000 claims 2
- 239000008116 calcium stearate Substances 0.000 claims 2
- 229940078456 calcium stearate Drugs 0.000 claims 2
- 229940105112 magnesium myristate Drugs 0.000 claims 2
- 235000019359 magnesium stearate Nutrition 0.000 claims 2
- 229940057948 magnesium stearate Drugs 0.000 claims 2
- DMRBHZWQMKSQGR-UHFFFAOYSA-L magnesium;tetradecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O DMRBHZWQMKSQGR-UHFFFAOYSA-L 0.000 claims 2
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 claims 2
- 229940082004 sodium laurate Drugs 0.000 claims 2
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims 2
- 229940080350 sodium stearate Drugs 0.000 claims 2
- 229940098697 zinc laurate Drugs 0.000 claims 2
- 229940105125 zinc myristate Drugs 0.000 claims 2
- 229940012185 zinc palmitate Drugs 0.000 claims 2
- GPYYEEJOMCKTPR-UHFFFAOYSA-L zinc;dodecanoate Chemical compound [Zn+2].CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O GPYYEEJOMCKTPR-UHFFFAOYSA-L 0.000 claims 2
- GJAPSKMAVXDBIU-UHFFFAOYSA-L zinc;hexadecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O GJAPSKMAVXDBIU-UHFFFAOYSA-L 0.000 claims 2
- GBFLQPIIIRJQLU-UHFFFAOYSA-L zinc;tetradecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O GBFLQPIIIRJQLU-UHFFFAOYSA-L 0.000 claims 2
- RUIHWYUMABEPAP-UHFFFAOYSA-L zinc;undec-2-ynoate Chemical compound [Zn+2].CCCCCCCCC#CC([O-])=O.CCCCCCCCC#CC([O-])=O RUIHWYUMABEPAP-UHFFFAOYSA-L 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 claims 1
- 229940063655 aluminum stearate Drugs 0.000 claims 1
- QRZAKQDHEVVFRX-UHFFFAOYSA-N biphenyl-4-ylacetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=CC=CC=C1 QRZAKQDHEVVFRX-UHFFFAOYSA-N 0.000 claims 1
- 229960000192 felbinac Drugs 0.000 claims 1
- 229960002390 flurbiprofen Drugs 0.000 claims 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 1
- 229960000991 ketoprofen Drugs 0.000 claims 1
- -1 ketrolac Chemical compound 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 229940114926 stearate Drugs 0.000 claims 1
- 229940057977 zinc stearate Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
An adhesive patch containing a non-steroidal anti--inflammatory agent, comprising a support and an adhesive layer laminated on this support, wherein the adhesive layer contains a non--steroidal anti-inflammatory agent having a carboxyl group or its salt, and polyethylene glycol having an average molecular weight of 1000 or more.
Claims (9)
1. An adhesive patch containing a non-steroidal anti-inflammatory agent, comprising a support and an adhesive layer laminated on said support, wherein:
said adhesive layer contains a non-steroidal anti-inflammatory agent having a carboxyl group or its salt, and polyethylene glycol having an average molecular weight of 1000 or more.
said adhesive layer contains a non-steroidal anti-inflammatory agent having a carboxyl group or its salt, and polyethylene glycol having an average molecular weight of 1000 or more.
2. The adhesive patch containing a non-steroidal anti-inflammatory agent according to claim 1, further comprising a fatty acid metal salt in said adhesive layer.
3. The adhesive patch containing a non-steroidal anti-inflammatory agent according to claim 2, wherein said fatty acid metal salt is at least one moeity selected from among a group comprising zinc undecynate, zinc stearate, aluminum. stearate, calcium stearate, magnesium stearate, sodium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate and sodium laurate.
4. The adhesive patch containing a non-steroidal anti-inflammatory agent according to claim 3, wherein said fatty acid metal salt is zinc stearate.
5. The adhesive patch containing a non-steroidal anti-inflammatory agent according to any of claims 1-4, wherein said non-steroidal anti-inflammatory agent is at least one moeity selected from a group comprising ketoprofen, diclofenac, flurbiprofen, ketrolac, felbinac or their pharmacological acceptable salts.
6. The adhesive patch containing a non-steroidal anti-inflammatory agent according to any of claims 1-4, wherein said non-steroidal anti-inflammatory agent is at least one moeity selected from among a group comprising diclofenac and its pharmacologically acceptable salts.
7. The adhesive patch containing a non-steroidal anti-inflammatory agent according to claim 2, wherein:
said non-steroidal anti-inflammatory agent is at least one moeity selected from among a group comprising diclofenac and its pharmacologically acceptable salts; and said adhesive layer contains 1-25 mass % of at least one moeity selected from among a group comprising diclofenac and its pharmacologically acceptable salts, 1-6 mass % of polyethylene glycol having an average molecular weight of 1000 or more, and 1-6 mass %
of said fatty acid metal salt.
said non-steroidal anti-inflammatory agent is at least one moeity selected from among a group comprising diclofenac and its pharmacologically acceptable salts; and said adhesive layer contains 1-25 mass % of at least one moeity selected from among a group comprising diclofenac and its pharmacologically acceptable salts, 1-6 mass % of polyethylene glycol having an average molecular weight of 1000 or more, and 1-6 mass %
of said fatty acid metal salt.
8. The adhesive patch containing a non-steroidal anti-inflammatory agent according to claim 7, wherein said fatty acid metal salt is at least one moeity selected from among a group comprising zinc undecynate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, sodium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate and sodium laurate.
9. The adhesive patch containing a non-steroidal anti-inflammatory agent according to claim 7, wherein said fatty acid metal salt is zinc stearate.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003074117 | 2003-03-18 | ||
| JP2003-074117 | 2003-03-18 | ||
| PCT/JP2004/003664 WO2004082672A1 (en) | 2003-03-18 | 2004-03-18 | Patch containing nonsteroidal antiinflammatory and analgesic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2519195A1 true CA2519195A1 (en) | 2004-09-30 |
| CA2519195C CA2519195C (en) | 2012-05-08 |
Family
ID=33027805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2519195A Expired - Lifetime CA2519195C (en) | 2003-03-18 | 2004-03-18 | Adhesive patch containing non-steroidal anti-inflammatory agent |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8034374B2 (en) |
| EP (1) | EP1611884B1 (en) |
| JP (1) | JP4614881B2 (en) |
| KR (1) | KR101105612B1 (en) |
| CN (1) | CN1761462B (en) |
| BR (1) | BRPI0408457B8 (en) |
| CA (1) | CA2519195C (en) |
| DK (1) | DK1611884T3 (en) |
| ES (1) | ES2397217T3 (en) |
| HK (1) | HK1086749A1 (en) |
| TW (1) | TW200501939A (en) |
| WO (1) | WO2004082672A1 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060182819A1 (en) * | 2005-02-17 | 2006-08-17 | Ough Yon D | Soap scent patch and treatment for muscle spasm and pain |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| RU2509076C2 (en) | 2007-06-04 | 2014-03-10 | Текфилдз Инк | Prodrugs of nonsteroid anti-inflammatory agents (nsaia) with very high speed of penetration through skin and membranes, and new medical applications of above said prodrugs |
| HUP0700828A2 (en) * | 2007-12-20 | 2010-01-28 | Richter Gedeon Nyrt | Transdermal pharmaceutical compositions containing tolperisone alone and in combination |
| JP4879928B2 (en) * | 2008-03-25 | 2012-02-22 | 帝國製薬株式会社 | Aqueous patch containing ketoprofen lysine salt |
| JP5704801B2 (en) * | 2008-08-21 | 2015-04-22 | ニプロパッチ株式会社 | Adhesive composition and transdermal preparation |
| JP5410070B2 (en) * | 2008-10-07 | 2014-02-05 | 久光製薬株式会社 | Metal carbonate as esterification inhibitor and method for inhibiting esterification with metal carbonate |
| KR101753296B1 (en) | 2008-12-04 | 2017-07-03 | 충시 위 | High Penetration Compositions and Their Applications |
| KR101819251B1 (en) * | 2010-04-13 | 2018-01-16 | 도아고세이가부시키가이샤 | Adhesive composition for medical use, adhesive patch for medical use, and method for producing the composition |
| KR101778823B1 (en) * | 2010-04-30 | 2017-09-14 | 히사미쓰 세이야꾸 가부시키가이샤 | Device to aid in applying transdermal patches |
| SE535588C2 (en) * | 2010-10-29 | 2012-10-02 | Redsense Medical Ab | Detection of blood leakage by detecting the presence of volatiles |
| CN102000043B (en) * | 2010-11-19 | 2013-11-06 | 沈阳药科大学 | Flurbiprofen salt transdermal patch and preparation method thereof |
| GB201120908D0 (en) | 2011-12-06 | 2012-01-18 | Reckitt Benckiser Healthcare | Patch containing non-steroidal anti-inflammatory drug |
| WO2013191158A1 (en) * | 2012-06-20 | 2013-12-27 | 久光製薬株式会社 | Percutaneous absorption promoter and skin patch comprising same |
| JP5629745B2 (en) * | 2012-10-23 | 2014-11-26 | テックフィールズ バイオケム カンパニー リミテッド | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin permeability |
| EP3503855B1 (en) * | 2016-08-26 | 2021-12-29 | KCI Licensing, Inc. | Wound dressing with analgesic border adhesive |
| CN106692114A (en) * | 2016-12-27 | 2017-05-24 | 毛嘉明 | Novel ketoprofen patch and preparation method thereof |
| JP7117748B2 (en) * | 2017-09-22 | 2022-08-15 | 帝國製薬株式会社 | patch |
| WO2019177117A1 (en) | 2018-03-14 | 2019-09-19 | 日本ケミファ株式会社 | Drug for treating cough |
| CN112206222A (en) * | 2018-11-09 | 2021-01-12 | 北京德默高科医药技术有限公司 | Multi-layer transdermal drug delivery system containing ibuprofen structural analogs |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1248450A (en) * | 1984-04-05 | 1989-01-10 | Kazuo Kigasawa | Soft patch |
| US5120545A (en) * | 1990-08-03 | 1992-06-09 | Alza Corporation | Reduction or prevention of sensitization to drugs |
| US5639738A (en) * | 1992-02-20 | 1997-06-17 | Hyal Pharmaceutical Corporation | Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs |
| ES2304783T3 (en) * | 1994-09-16 | 2008-10-16 | Hisamitsu Pharmaceutical Co., Inc. | EXTERNAL USE PATCH. |
| US5945125A (en) * | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| JP4275751B2 (en) | 1996-12-27 | 2009-06-10 | 久光製薬株式会社 | Composition for external use |
| JP4181232B2 (en) * | 1997-07-18 | 2008-11-12 | 帝國製薬株式会社 | Diclofenac sodium-containing oily external patch preparation |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| KR100360827B1 (en) * | 1999-08-14 | 2002-11-18 | 주식회사 삼양사 | Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof |
| JP4659943B2 (en) | 2000-02-25 | 2011-03-30 | 帝三製薬株式会社 | Patch containing buprenorphine hydrochloride |
| CA2406261C (en) | 2000-04-18 | 2010-12-07 | Hisamitsu Pharmaceutical Co., Inc. | Antiinflammatory-containing plaster |
| JP4625157B2 (en) * | 2000-04-27 | 2011-02-02 | ニプロパッチ株式会社 | Indomethacin patch |
| US6455067B1 (en) * | 2000-05-24 | 2002-09-24 | Sang-A Pharmaceutical Co., Ltd. | Transdermal patch for nonsteroidal antiinflammatory drug(s) |
| JP4648518B2 (en) | 2000-06-01 | 2011-03-09 | 帝國製薬株式会社 | Patch containing 4-biphenylacetic acid |
| JP2002020274A (en) * | 2000-06-12 | 2002-01-23 | San-A Seiyaku Kk | Non-steroidal anti-inflammatory analgesic transdermal patch agent for outer application and transdermal patch for outer application |
| JP2002193793A (en) | 2000-12-26 | 2002-07-10 | Teikoku Seiyaku Co Ltd | Non-steroidal antiinflammatory analgesic plaster |
| JP2002226366A (en) | 2001-02-02 | 2002-08-14 | Yuutoku Yakuhin Kogyo Kk | Liniment preparation for external use |
| CA2448689C (en) * | 2001-05-31 | 2009-09-01 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously absorbable patches |
| KR100941909B1 (en) | 2002-02-19 | 2010-02-16 | 히사미쓰 세이야꾸 가부시키가이샤 | Percutaneous absorption type plaster |
-
2004
- 2004-03-18 WO PCT/JP2004/003664 patent/WO2004082672A1/en active Application Filing
- 2004-03-18 CA CA2519195A patent/CA2519195C/en not_active Expired - Lifetime
- 2004-03-18 BR BRPI0408457A patent/BRPI0408457B8/en active IP Right Grant
- 2004-03-18 TW TW093107590A patent/TW200501939A/en unknown
- 2004-03-18 DK DK04721660.1T patent/DK1611884T3/en active
- 2004-03-18 CN CN200480007150XA patent/CN1761462B/en not_active Expired - Lifetime
- 2004-03-18 EP EP04721660A patent/EP1611884B1/en not_active Expired - Lifetime
- 2004-03-18 US US10/549,184 patent/US8034374B2/en active Active
- 2004-03-18 KR KR1020057017273A patent/KR101105612B1/en active IP Right Grant
- 2004-03-18 JP JP2005503745A patent/JP4614881B2/en not_active Expired - Lifetime
- 2004-03-18 ES ES04721660T patent/ES2397217T3/en not_active Expired - Lifetime
-
2006
- 2006-06-15 HK HK06106877.9A patent/HK1086749A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1761462B (en) | 2010-04-21 |
| JPWO2004082672A1 (en) | 2006-06-22 |
| CA2519195C (en) | 2012-05-08 |
| US8034374B2 (en) | 2011-10-11 |
| DK1611884T3 (en) | 2012-12-10 |
| EP1611884A4 (en) | 2010-02-24 |
| BRPI0408457B1 (en) | 2018-11-27 |
| EP1611884A1 (en) | 2006-01-04 |
| JP4614881B2 (en) | 2011-01-19 |
| TW200501939A (en) | 2005-01-16 |
| BRPI0408457A (en) | 2006-04-04 |
| TWI321470B (en) | 2010-03-11 |
| US20060172002A1 (en) | 2006-08-03 |
| BRPI0408457B8 (en) | 2021-05-25 |
| EP1611884B1 (en) | 2012-11-14 |
| ES2397217T3 (en) | 2013-03-05 |
| CN1761462A (en) | 2006-04-19 |
| HK1086749A1 (en) | 2006-09-29 |
| WO2004082672A1 (en) | 2004-09-30 |
| KR101105612B1 (en) | 2012-01-18 |
| AU2004222442A1 (en) | 2004-09-30 |
| KR20050107804A (en) | 2005-11-15 |
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